#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P01308	uniprotkb:P01308	intact:EBI-7090529|ensembl:ENSP00000250971|ensembl:ENSP00000370731|ensembl:ENSP00000380432|uniprotkb:Q5EEX2|intact:MINT-106847	intact:EBI-7090529|ensembl:ENSP00000250971|ensembl:ENSP00000370731|ensembl:ENSP00000380432|uniprotkb:Q5EEX2|intact:MINT-106847	psi-mi:ins_human(display_long)|uniprotkb:INS(gene name)|psi-mi:INS(display_short)	psi-mi:ins_human(display_long)|uniprotkb:INS(gene name)|psi-mi:INS(display_short)	psi-mi:"MI:0826"(x ray scattering)	Vestergaard et al. (2007)	pubmed:17472440|doi:10.1371/journal.pbio.0050134|imex:IM-8677	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15635490|imex:IM-8677-1|dip:DIP-57415E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001278826.1|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005796"(Golgi lumen)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006521"(regulation of cellular amino acid metabolic process)|go:"GO:0006953"(acute-phase response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010750"(positive regulation of nitric oxide mediated signal transduction)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030133"(transport vesicle)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031904"(endosome lumen)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0033861"("negative regulation of NAD(P)H oxidase activity")|go:"GO:0034774"(secretory granule lumen)|go:"GO:0038060"(nitric oxide-cGMP-mediated signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042311"(vasodilation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0045818"(negative regulation of glycogen catabolic process)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045922"(negative regulation of fatty acid metabolic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046631"(alpha-beta T cell activation)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0050890"(cognition)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060266"(negative regulation of respiratory burst involved in inflammatory response)|go:"GO:0060267"(positive regulation of respiratory burst)|go:"GO:0090277"(positive regulation of peptide hormone secretion)|go:"GO:0005179"(hormone activity)|go:"GO:0090336"(positive regulation of brown fat cell differentiation)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|go:"GO:1990535"(neuron projection maintenance)|go:"GO:2000252"(negative regulation of feeding behavior)|interpro:IPR004825(Insulin/IGF/relaxin)|interpro:IPR016179(Insulin-like)|interpro:IPR022352|interpro:IPR022353|interpro:IPR036438|mint:P01308|rcsb pdb:1A7F|rcsb pdb:1AI0|rcsb pdb:1AIY|rcsb pdb:1B9E|rcsb pdb:1BEN|rcsb pdb:1EFE|rcsb pdb:1EV3|rcsb pdb:1EV6|rcsb pdb:1EVR|rcsb pdb:1FU2|rcsb pdb:1FUB|rcsb pdb:1G7A|rcsb pdb:1G7B|rcsb pdb:1GUJ|rcsb pdb:1HIQ|rcsb pdb:1HIS|rcsb pdb:1HIT|rcsb pdb:1HLS|rcsb pdb:1HTV|rcsb pdb:1HUI|rcsb pdb:1IOG|rcsb pdb:1IOH|rcsb pdb:1J73|rcsb pdb:1JCA|rcsb pdb:1JCO|rcsb pdb:1JK8|rcsb pdb:1K3M|rcsb pdb:1KMF|rcsb pdb:1LKQ|rcsb pdb:1LPH|rcsb pdb:1MHI|rcsb pdb:1MHJ|rcsb pdb:1MSO|rcsb pdb:1OS3|rcsb pdb:1OS4|rcsb pdb:1Q4V|rcsb pdb:1QIY|rcsb pdb:1QIZ|rcsb pdb:1QJ0|rcsb pdb:1RWE|rcsb pdb:1SF1|rcsb pdb:1SJT|rcsb pdb:1SJU|rcsb pdb:1T0C|rcsb pdb:1T1K|rcsb pdb:1T1P|rcsb pdb:1T1Q|rcsb pdb:1TRZ|rcsb pdb:1TYL|rcsb pdb:1TYM|rcsb pdb:1UZ9|rcsb pdb:1VKT|rcsb pdb:1W8P|rcsb pdb:1XDA|rcsb pdb:1XGL|rcsb pdb:1XW7|rcsb pdb:1ZEG|rcsb pdb:1ZEH|rcsb pdb:1ZNJ|rcsb pdb:2AIY|rcsb pdb:2C8Q|rcsb pdb:2C8R|rcsb pdb:2CEU|rcsb pdb:2G54|rcsb pdb:2G56|rcsb pdb:2H67|rcsb pdb:2HH4|rcsb pdb:2HHO|rcsb pdb:2HIU|rcsb pdb:2JMN|rcsb pdb:2JUM|rcsb pdb:2JUU|rcsb pdb:2JUV|rcsb pdb:2JZQ|rcsb pdb:2K91|rcsb pdb:2K9R|rcsb pdb:2KJJ|rcsb pdb:2KJU|rcsb pdb:2JV1|rcsb pdb:2KQP|rcsb pdb:2KQQ|rcsb pdb:2KXK|rcsb pdb:2L1Y|rcsb pdb:2L1Z|rcsb pdb:2LGB|rcsb pdb:2LWZ|rcsb pdb:2M1D|rcsb pdb:2M1E|rcsb pdb:2M2M|rcsb pdb:2M2N|rcsb pdb:2M2O|rcsb pdb:2M2P|rcsb pdb:2MLI|rcsb pdb:2MPG|rcsb pdb:2MPI|rcsb pdb:2MVC|rcsb pdb:2MVD|rcsb pdb:2N2V|rcsb pdb:2N2W|rcsb pdb:2N2X|rcsb pdb:2OLY|rcsb pdb:2OLZ|rcsb pdb:2OM0|rcsb pdb:2OM1|rcsb pdb:2OMG|rcsb pdb:2OMH|rcsb pdb:2OMI|rcsb pdb:2OMQ|rcsb pdb:2QIU|rcsb pdb:2R34|rcsb pdb:2R35|rcsb pdb:2R36|rcsb pdb:2RN5|rcsb pdb:2VJZ|rcsb pdb:2VK0|rcsb pdb:2W44|rcsb pdb:2WBY|rcsb pdb:2WC0|rcsb pdb:2WRU|rcsb pdb:2WRV|rcsb pdb:2WRW|rcsb pdb:2WRX|rcsb pdb:2WS0|rcsb pdb:2WS1|rcsb pdb:2WS4|rcsb pdb:2WS6|rcsb pdb:2WS7|rcsb pdb:3AIY|rcsb pdb:3BXQ|rcsb pdb:3E7Y|rcsb pdb:3E7Z|rcsb pdb:3EXX|rcsb pdb:3FQ9|rcsb pdb:3HYD|rcsb pdb:3I3Z|rcsb pdb:3I40|rcsb pdb:3ILG|rcsb pdb:3INC|rcsb pdb:3IR0|rcsb pdb:3JSD|rcsb pdb:3KQ6|rcsb pdb:3P2X|rcsb pdb:3P33|rcsb pdb:3Q6E|rcsb pdb:3ROV|rcsb pdb:3TT8|rcsb pdb:3U4N|rcsb pdb:3UTQ|rcsb pdb:3UTS|rcsb pdb:3UTT|rcsb pdb:3V19|rcsb pdb:3V1G|rcsb pdb:3W11|rcsb pdb:3W12|rcsb pdb:3W13|rcsb pdb:3W7Y|rcsb pdb:3W7Z|rcsb pdb:3W80|rcsb pdb:3ZI3|rcsb pdb:3ZQR|rcsb pdb:3ZS2|rcsb pdb:3ZU1|rcsb pdb:4AIY|rcsb pdb:4AJX|rcsb pdb:4AJZ|rcsb pdb:4AK0|rcsb pdb:4AKJ|rcsb pdb:4CXL|rcsb pdb:4CXN|rcsb pdb:4CY7|rcsb pdb:4EFX|rcsb pdb:4EWW|rcsb pdb:4EWX|rcsb pdb:4EWZ|rcsb pdb:4EX0|rcsb pdb:4EX1|rcsb pdb:4EXX|rcsb pdb:4EY1|rcsb pdb:4EY9|rcsb pdb:4EYD|rcsb pdb:4EYN|rcsb pdb:4EYP|rcsb pdb:4F0N|rcsb pdb:4F0O|rcsb pdb:4F1A|rcsb pdb:4F1B|rcsb pdb:4F1C|rcsb pdb:4F1D|rcsb pdb:4F1F|rcsb pdb:4F1G|rcsb pdb:4F4T|rcsb pdb:4F4V|rcsb pdb:4F51|rcsb pdb:4F8F|rcsb pdb:4FG3|rcsb pdb:4FKA|rcsb pdb:4GBC|rcsb pdb:4GBI|rcsb pdb:4GBK|rcsb pdb:4GBL|rcsb pdb:4GBN|rcsb pdb:4IUZ|rcsb pdb:4IYD|rcsb pdb:4IYF|rcsb pdb:4NIB|rcsb pdb:4OGA|rcsb pdb:4P65|rcsb pdb:4RXW|rcsb pdb:4UNE|rcsb pdb:4UNG|rcsb pdb:4UNH|rcsb pdb:4WDI|rcsb pdb:4XC4|rcsb pdb:4Y19|rcsb pdb:4Y1A|rcsb pdb:4Z76|rcsb pdb:4Z77|rcsb pdb:4Z78|rcsb pdb:5AIY|rcsb pdb:5BOQ|rcsb pdb:5BPO|rcsb pdb:5BQQ|rcsb pdb:5BTS|rcsb pdb:5C0D|rcsb pdb:5CJO|rcsb pdb:5CNY|rcsb pdb:5CO2|rcsb pdb:5CO6|rcsb pdb:5CO9|rcsb pdb:5E7W|rcsb pdb:5EMS|rcsb pdb:5EN9|rcsb pdb:5ENA|rcsb pdb:5HPR|rcsb pdb:5HPU|rcsb pdb:5HQI|rcsb pdb:5HRQ|rcsb pdb:5HYJ|rcsb pdb:5MAM|rcsb pdb:5MHD|rcsb pdb:5MT3|rcsb pdb:5MT9|rcsb pdb:5MWQ|rcsb pdb:5T7R|rcsb pdb:5UDP|rcsb pdb:5UOZ|rcsb pdb:5UQA|rcsb pdb:5URT|rcsb pdb:5URU|rcsb pdb:5USP|rcsb pdb:5USS|rcsb pdb:5USV|rcsb pdb:5UU2|rcsb pdb:5UU3|rcsb pdb:5UU4|rcsb pdb:5VIZ|rcsb pdb:5WBT|rcsb pdb:5WDM|rcsb pdb:5WOB|rcsb pdb:6B3Q|rcsb pdb:6B70|rcsb pdb:6BFC|rcsb pdb:6CE7|rcsb pdb:6CE9|rcsb pdb:6CEB|rcsb pdb:6CK2|rcsb pdb:6GNQ|rcsb pdb:6GV0|rcsb pdb:6H3M|rcsb pdb:6HN5|rcsb pdb:6JR3|rcsb pdb:6K59|rcsb pdb:6NWV|rcsb pdb:6O17|rcsb pdb:6P4Z|rcsb pdb:6S34|rcsb pdb:6S4I|rcsb pdb:6S4J|rcsb pdb:6SOF|rcsb pdb:6TC2|rcsb pdb:6TYH|rcsb pdb:6U46|rcsb pdb:6VEP|rcsb pdb:6VER|rcsb pdb:6VES|rcsb pdb:6VET|rcsb pdb:6X4X|rcsb pdb:6Z7W|rcsb pdb:6Z7Y|rcsb pdb:7BW7|rcsb pdb:7BW8|rcsb pdb:7BWA|rcsb pdb:7NHU|reactome:R-HSA-210745|reactome:R-HSA-264876|reactome:R-HSA-422085|reactome:R-HSA-422356|reactome:R-HSA-6807878|reactome:R-HSA-6811558|reactome:R-HSA-74713|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-74752|reactome:R-HSA-77387|reactome:R-HSA-9615017|reactome:R-HSA-977225|rcsb pdb:6JK8|ensembl:ENSG00000254647(gene)|ensembl:ENST00000250971(transcript)|ensembl:ENST00000381330(transcript)|ensembl:ENST00000397262(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002020"(protease binding)|go:"GO:0002674"(negative regulation of acute inflammatory response)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|refseq:NP_001172026.1|refseq:NP_000198.1|refseq:NP_001172027.1|dip:DIP-6024N	refseq:NP_001278826.1|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005796"(Golgi lumen)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006521"(regulation of cellular amino acid metabolic process)|go:"GO:0006953"(acute-phase response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010750"(positive regulation of nitric oxide mediated signal transduction)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030133"(transport vesicle)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031904"(endosome lumen)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0033861"("negative regulation of NAD(P)H oxidase activity")|go:"GO:0034774"(secretory granule lumen)|go:"GO:0038060"(nitric oxide-cGMP-mediated signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042311"(vasodilation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0045818"(negative regulation of glycogen catabolic process)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045922"(negative regulation of fatty acid metabolic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046631"(alpha-beta T cell activation)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0050890"(cognition)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060266"(negative regulation of respiratory burst involved in inflammatory response)|go:"GO:0060267"(positive regulation of respiratory burst)|go:"GO:0090277"(positive regulation of peptide hormone secretion)|go:"GO:0005179"(hormone activity)|go:"GO:0090336"(positive regulation of brown fat cell differentiation)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|go:"GO:1990535"(neuron projection maintenance)|go:"GO:2000252"(negative regulation of feeding behavior)|interpro:IPR004825(Insulin/IGF/relaxin)|interpro:IPR016179(Insulin-like)|interpro:IPR022352|interpro:IPR022353|interpro:IPR036438|mint:P01308|rcsb pdb:1A7F|rcsb pdb:1AI0|rcsb pdb:1AIY|rcsb pdb:1B9E|rcsb pdb:1BEN|rcsb pdb:1EFE|rcsb pdb:1EV3|rcsb pdb:1EV6|rcsb pdb:1EVR|rcsb pdb:1FU2|rcsb pdb:1FUB|rcsb pdb:1G7A|rcsb pdb:1G7B|rcsb pdb:1GUJ|rcsb pdb:1HIQ|rcsb pdb:1HIS|rcsb pdb:1HIT|rcsb pdb:1HLS|rcsb pdb:1HTV|rcsb pdb:1HUI|rcsb pdb:1IOG|rcsb pdb:1IOH|rcsb pdb:1J73|rcsb pdb:1JCA|rcsb pdb:1JCO|rcsb pdb:1JK8|rcsb pdb:1K3M|rcsb pdb:1KMF|rcsb pdb:1LKQ|rcsb pdb:1LPH|rcsb pdb:1MHI|rcsb pdb:1MHJ|rcsb pdb:1MSO|rcsb pdb:1OS3|rcsb pdb:1OS4|rcsb pdb:1Q4V|rcsb pdb:1QIY|rcsb pdb:1QIZ|rcsb pdb:1QJ0|rcsb pdb:1RWE|rcsb pdb:1SF1|rcsb pdb:1SJT|rcsb pdb:1SJU|rcsb pdb:1T0C|rcsb pdb:1T1K|rcsb pdb:1T1P|rcsb pdb:1T1Q|rcsb pdb:1TRZ|rcsb pdb:1TYL|rcsb pdb:1TYM|rcsb pdb:1UZ9|rcsb pdb:1VKT|rcsb pdb:1W8P|rcsb pdb:1XDA|rcsb pdb:1XGL|rcsb pdb:1XW7|rcsb pdb:1ZEG|rcsb pdb:1ZEH|rcsb pdb:1ZNJ|rcsb pdb:2AIY|rcsb pdb:2C8Q|rcsb pdb:2C8R|rcsb pdb:2CEU|rcsb pdb:2G54|rcsb pdb:2G56|rcsb pdb:2H67|rcsb pdb:2HH4|rcsb pdb:2HHO|rcsb pdb:2HIU|rcsb pdb:2JMN|rcsb pdb:2JUM|rcsb pdb:2JUU|rcsb pdb:2JUV|rcsb pdb:2JZQ|rcsb pdb:2K91|rcsb pdb:2K9R|rcsb pdb:2KJJ|rcsb pdb:2KJU|rcsb pdb:2JV1|rcsb pdb:2KQP|rcsb pdb:2KQQ|rcsb pdb:2KXK|rcsb pdb:2L1Y|rcsb pdb:2L1Z|rcsb pdb:2LGB|rcsb pdb:2LWZ|rcsb pdb:2M1D|rcsb pdb:2M1E|rcsb pdb:2M2M|rcsb pdb:2M2N|rcsb pdb:2M2O|rcsb pdb:2M2P|rcsb pdb:2MLI|rcsb pdb:2MPG|rcsb pdb:2MPI|rcsb pdb:2MVC|rcsb pdb:2MVD|rcsb pdb:2N2V|rcsb pdb:2N2W|rcsb pdb:2N2X|rcsb pdb:2OLY|rcsb pdb:2OLZ|rcsb pdb:2OM0|rcsb pdb:2OM1|rcsb pdb:2OMG|rcsb pdb:2OMH|rcsb pdb:2OMI|rcsb pdb:2OMQ|rcsb pdb:2QIU|rcsb pdb:2R34|rcsb pdb:2R35|rcsb pdb:2R36|rcsb pdb:2RN5|rcsb pdb:2VJZ|rcsb pdb:2VK0|rcsb pdb:2W44|rcsb pdb:2WBY|rcsb pdb:2WC0|rcsb pdb:2WRU|rcsb pdb:2WRV|rcsb pdb:2WRW|rcsb pdb:2WRX|rcsb pdb:2WS0|rcsb pdb:2WS1|rcsb pdb:2WS4|rcsb pdb:2WS6|rcsb pdb:2WS7|rcsb pdb:3AIY|rcsb pdb:3BXQ|rcsb pdb:3E7Y|rcsb pdb:3E7Z|rcsb pdb:3EXX|rcsb pdb:3FQ9|rcsb pdb:3HYD|rcsb pdb:3I3Z|rcsb pdb:3I40|rcsb pdb:3ILG|rcsb pdb:3INC|rcsb pdb:3IR0|rcsb pdb:3JSD|rcsb pdb:3KQ6|rcsb pdb:3P2X|rcsb pdb:3P33|rcsb pdb:3Q6E|rcsb pdb:3ROV|rcsb pdb:3TT8|rcsb pdb:3U4N|rcsb pdb:3UTQ|rcsb pdb:3UTS|rcsb pdb:3UTT|rcsb pdb:3V19|rcsb pdb:3V1G|rcsb pdb:3W11|rcsb pdb:3W12|rcsb pdb:3W13|rcsb pdb:3W7Y|rcsb pdb:3W7Z|rcsb pdb:3W80|rcsb pdb:3ZI3|rcsb pdb:3ZQR|rcsb pdb:3ZS2|rcsb pdb:3ZU1|rcsb pdb:4AIY|rcsb pdb:4AJX|rcsb pdb:4AJZ|rcsb pdb:4AK0|rcsb pdb:4AKJ|rcsb pdb:4CXL|rcsb pdb:4CXN|rcsb pdb:4CY7|rcsb pdb:4EFX|rcsb pdb:4EWW|rcsb pdb:4EWX|rcsb pdb:4EWZ|rcsb pdb:4EX0|rcsb pdb:4EX1|rcsb pdb:4EXX|rcsb pdb:4EY1|rcsb pdb:4EY9|rcsb pdb:4EYD|rcsb pdb:4EYN|rcsb pdb:4EYP|rcsb pdb:4F0N|rcsb pdb:4F0O|rcsb pdb:4F1A|rcsb pdb:4F1B|rcsb pdb:4F1C|rcsb pdb:4F1D|rcsb pdb:4F1F|rcsb pdb:4F1G|rcsb pdb:4F4T|rcsb pdb:4F4V|rcsb pdb:4F51|rcsb pdb:4F8F|rcsb pdb:4FG3|rcsb pdb:4FKA|rcsb pdb:4GBC|rcsb pdb:4GBI|rcsb pdb:4GBK|rcsb pdb:4GBL|rcsb pdb:4GBN|rcsb pdb:4IUZ|rcsb pdb:4IYD|rcsb pdb:4IYF|rcsb pdb:4NIB|rcsb pdb:4OGA|rcsb pdb:4P65|rcsb pdb:4RXW|rcsb pdb:4UNE|rcsb pdb:4UNG|rcsb pdb:4UNH|rcsb pdb:4WDI|rcsb pdb:4XC4|rcsb pdb:4Y19|rcsb pdb:4Y1A|rcsb pdb:4Z76|rcsb pdb:4Z77|rcsb pdb:4Z78|rcsb pdb:5AIY|rcsb pdb:5BOQ|rcsb pdb:5BPO|rcsb pdb:5BQQ|rcsb pdb:5BTS|rcsb pdb:5C0D|rcsb pdb:5CJO|rcsb pdb:5CNY|rcsb pdb:5CO2|rcsb pdb:5CO6|rcsb pdb:5CO9|rcsb pdb:5E7W|rcsb pdb:5EMS|rcsb pdb:5EN9|rcsb pdb:5ENA|rcsb pdb:5HPR|rcsb pdb:5HPU|rcsb pdb:5HQI|rcsb pdb:5HRQ|rcsb pdb:5HYJ|rcsb pdb:5MAM|rcsb pdb:5MHD|rcsb pdb:5MT3|rcsb pdb:5MT9|rcsb pdb:5MWQ|rcsb pdb:5T7R|rcsb pdb:5UDP|rcsb pdb:5UOZ|rcsb pdb:5UQA|rcsb pdb:5URT|rcsb pdb:5URU|rcsb pdb:5USP|rcsb pdb:5USS|rcsb pdb:5USV|rcsb pdb:5UU2|rcsb pdb:5UU3|rcsb pdb:5UU4|rcsb pdb:5VIZ|rcsb pdb:5WBT|rcsb pdb:5WDM|rcsb pdb:5WOB|rcsb pdb:6B3Q|rcsb pdb:6B70|rcsb pdb:6BFC|rcsb pdb:6CE7|rcsb pdb:6CE9|rcsb pdb:6CEB|rcsb pdb:6CK2|rcsb pdb:6GNQ|rcsb pdb:6GV0|rcsb pdb:6H3M|rcsb pdb:6HN5|rcsb pdb:6JR3|rcsb pdb:6K59|rcsb pdb:6NWV|rcsb pdb:6O17|rcsb pdb:6P4Z|rcsb pdb:6S34|rcsb pdb:6S4I|rcsb pdb:6S4J|rcsb pdb:6SOF|rcsb pdb:6TC2|rcsb pdb:6TYH|rcsb pdb:6U46|rcsb pdb:6VEP|rcsb pdb:6VER|rcsb pdb:6VES|rcsb pdb:6VET|rcsb pdb:6X4X|rcsb pdb:6Z7W|rcsb pdb:6Z7Y|rcsb pdb:7BW7|rcsb pdb:7BW8|rcsb pdb:7BWA|rcsb pdb:7NHU|reactome:R-HSA-210745|reactome:R-HSA-264876|reactome:R-HSA-422085|reactome:R-HSA-422356|reactome:R-HSA-6807878|reactome:R-HSA-6811558|reactome:R-HSA-74713|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-74752|reactome:R-HSA-77387|reactome:R-HSA-9615017|reactome:R-HSA-977225|rcsb pdb:6JK8|ensembl:ENSG00000254647(gene)|ensembl:ENST00000250971(transcript)|ensembl:ENST00000381330(transcript)|ensembl:ENST00000397262(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002020"(protease binding)|go:"GO:0002674"(negative regulation of acute inflammatory response)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|refseq:NP_001172026.1|refseq:NP_000198.1|refseq:NP_001172027.1|dip:DIP-6024N	psi-mi:"MI:0465"(dip)	function:Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver|comment:mint|comment:homomint|function:"Defects in INS are the cause of familial hyperproinsulinemia [MIM:176730]"	function:Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver|comment:mint|comment:homomint|function:"Defects in INS are the cause of familial hyperproinsulinemia [MIM:176730]"	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:RFnbvRnJ3AIA4j1Se0KPx0RFhD89606	rogid:RFnbvRnJ3AIA4j1Se0KPx0RFhD89606	rigid:EsXC3x5nIMW+mMBAACV+W8932bQ	false	-	-	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01308	uniprotkb:P01308	intact:EBI-7090529|ensembl:ENSP00000250971|ensembl:ENSP00000370731|ensembl:ENSP00000380432|uniprotkb:Q5EEX2|intact:MINT-106847	intact:EBI-7090529|ensembl:ENSP00000250971|ensembl:ENSP00000370731|ensembl:ENSP00000380432|uniprotkb:Q5EEX2|intact:MINT-106847	psi-mi:ins_human(display_long)|uniprotkb:INS(gene name)|psi-mi:INS(display_short)	psi-mi:ins_human(display_long)|uniprotkb:INS(gene name)|psi-mi:INS(display_short)	psi-mi:"MI:0825"(x-ray fiber diffraction)	Vestergaard et al. (2007)	pubmed:17472440|doi:10.1371/journal.pbio.0050134|imex:IM-8677	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15635506|imex:IM-8677-2|dip:DIP-57415E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001278826.1|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005796"(Golgi lumen)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006521"(regulation of cellular amino acid metabolic process)|go:"GO:0006953"(acute-phase response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010750"(positive regulation of nitric oxide mediated signal transduction)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030133"(transport vesicle)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031904"(endosome lumen)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0033861"("negative regulation of NAD(P)H oxidase activity")|go:"GO:0034774"(secretory granule lumen)|go:"GO:0038060"(nitric oxide-cGMP-mediated signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042311"(vasodilation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0045818"(negative regulation of glycogen catabolic process)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045922"(negative regulation of fatty acid metabolic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046631"(alpha-beta T cell activation)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0050890"(cognition)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060266"(negative regulation of respiratory burst involved in inflammatory response)|go:"GO:0060267"(positive regulation of respiratory burst)|go:"GO:0090277"(positive regulation of peptide hormone secretion)|go:"GO:0005179"(hormone activity)|go:"GO:0090336"(positive regulation of brown fat cell differentiation)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|go:"GO:1990535"(neuron projection maintenance)|go:"GO:2000252"(negative regulation of feeding behavior)|interpro:IPR004825(Insulin/IGF/relaxin)|interpro:IPR016179(Insulin-like)|interpro:IPR022352|interpro:IPR022353|interpro:IPR036438|mint:P01308|rcsb pdb:1A7F|rcsb pdb:1AI0|rcsb pdb:1AIY|rcsb pdb:1B9E|rcsb pdb:1BEN|rcsb pdb:1EFE|rcsb pdb:1EV3|rcsb pdb:1EV6|rcsb pdb:1EVR|rcsb pdb:1FU2|rcsb pdb:1FUB|rcsb pdb:1G7A|rcsb pdb:1G7B|rcsb pdb:1GUJ|rcsb pdb:1HIQ|rcsb pdb:1HIS|rcsb pdb:1HIT|rcsb pdb:1HLS|rcsb pdb:1HTV|rcsb pdb:1HUI|rcsb pdb:1IOG|rcsb pdb:1IOH|rcsb pdb:1J73|rcsb pdb:1JCA|rcsb pdb:1JCO|rcsb pdb:1JK8|rcsb pdb:1K3M|rcsb pdb:1KMF|rcsb pdb:1LKQ|rcsb pdb:1LPH|rcsb pdb:1MHI|rcsb pdb:1MHJ|rcsb pdb:1MSO|rcsb pdb:1OS3|rcsb pdb:1OS4|rcsb pdb:1Q4V|rcsb pdb:1QIY|rcsb pdb:1QIZ|rcsb pdb:1QJ0|rcsb pdb:1RWE|rcsb pdb:1SF1|rcsb pdb:1SJT|rcsb pdb:1SJU|rcsb pdb:1T0C|rcsb pdb:1T1K|rcsb pdb:1T1P|rcsb pdb:1T1Q|rcsb pdb:1TRZ|rcsb pdb:1TYL|rcsb pdb:1TYM|rcsb pdb:1UZ9|rcsb pdb:1VKT|rcsb pdb:1W8P|rcsb pdb:1XDA|rcsb pdb:1XGL|rcsb pdb:1XW7|rcsb pdb:1ZEG|rcsb pdb:1ZEH|rcsb pdb:1ZNJ|rcsb pdb:2AIY|rcsb pdb:2C8Q|rcsb pdb:2C8R|rcsb pdb:2CEU|rcsb pdb:2G54|rcsb pdb:2G56|rcsb pdb:2H67|rcsb pdb:2HH4|rcsb pdb:2HHO|rcsb pdb:2HIU|rcsb pdb:2JMN|rcsb pdb:2JUM|rcsb pdb:2JUU|rcsb pdb:2JUV|rcsb pdb:2JZQ|rcsb pdb:2K91|rcsb pdb:2K9R|rcsb pdb:2KJJ|rcsb pdb:2KJU|rcsb pdb:2JV1|rcsb pdb:2KQP|rcsb pdb:2KQQ|rcsb pdb:2KXK|rcsb pdb:2L1Y|rcsb pdb:2L1Z|rcsb pdb:2LGB|rcsb pdb:2LWZ|rcsb pdb:2M1D|rcsb pdb:2M1E|rcsb pdb:2M2M|rcsb pdb:2M2N|rcsb pdb:2M2O|rcsb pdb:2M2P|rcsb pdb:2MLI|rcsb pdb:2MPG|rcsb pdb:2MPI|rcsb pdb:2MVC|rcsb pdb:2MVD|rcsb pdb:2N2V|rcsb pdb:2N2W|rcsb pdb:2N2X|rcsb pdb:2OLY|rcsb pdb:2OLZ|rcsb pdb:2OM0|rcsb pdb:2OM1|rcsb pdb:2OMG|rcsb pdb:2OMH|rcsb pdb:2OMI|rcsb pdb:2OMQ|rcsb pdb:2QIU|rcsb pdb:2R34|rcsb pdb:2R35|rcsb pdb:2R36|rcsb pdb:2RN5|rcsb pdb:2VJZ|rcsb pdb:2VK0|rcsb pdb:2W44|rcsb pdb:2WBY|rcsb pdb:2WC0|rcsb pdb:2WRU|rcsb pdb:2WRV|rcsb pdb:2WRW|rcsb pdb:2WRX|rcsb pdb:2WS0|rcsb pdb:2WS1|rcsb pdb:2WS4|rcsb pdb:2WS6|rcsb pdb:2WS7|rcsb pdb:3AIY|rcsb pdb:3BXQ|rcsb pdb:3E7Y|rcsb pdb:3E7Z|rcsb pdb:3EXX|rcsb pdb:3FQ9|rcsb pdb:3HYD|rcsb pdb:3I3Z|rcsb pdb:3I40|rcsb pdb:3ILG|rcsb pdb:3INC|rcsb pdb:3IR0|rcsb pdb:3JSD|rcsb pdb:3KQ6|rcsb pdb:3P2X|rcsb pdb:3P33|rcsb pdb:3Q6E|rcsb pdb:3ROV|rcsb pdb:3TT8|rcsb pdb:3U4N|rcsb pdb:3UTQ|rcsb pdb:3UTS|rcsb pdb:3UTT|rcsb pdb:3V19|rcsb pdb:3V1G|rcsb pdb:3W11|rcsb pdb:3W12|rcsb pdb:3W13|rcsb pdb:3W7Y|rcsb pdb:3W7Z|rcsb pdb:3W80|rcsb pdb:3ZI3|rcsb pdb:3ZQR|rcsb pdb:3ZS2|rcsb pdb:3ZU1|rcsb pdb:4AIY|rcsb pdb:4AJX|rcsb pdb:4AJZ|rcsb pdb:4AK0|rcsb pdb:4AKJ|rcsb pdb:4CXL|rcsb pdb:4CXN|rcsb pdb:4CY7|rcsb pdb:4EFX|rcsb pdb:4EWW|rcsb pdb:4EWX|rcsb pdb:4EWZ|rcsb pdb:4EX0|rcsb pdb:4EX1|rcsb pdb:4EXX|rcsb pdb:4EY1|rcsb pdb:4EY9|rcsb pdb:4EYD|rcsb pdb:4EYN|rcsb pdb:4EYP|rcsb pdb:4F0N|rcsb pdb:4F0O|rcsb pdb:4F1A|rcsb pdb:4F1B|rcsb pdb:4F1C|rcsb pdb:4F1D|rcsb pdb:4F1F|rcsb pdb:4F1G|rcsb pdb:4F4T|rcsb pdb:4F4V|rcsb pdb:4F51|rcsb pdb:4F8F|rcsb pdb:4FG3|rcsb pdb:4FKA|rcsb pdb:4GBC|rcsb pdb:4GBI|rcsb pdb:4GBK|rcsb pdb:4GBL|rcsb pdb:4GBN|rcsb pdb:4IUZ|rcsb pdb:4IYD|rcsb pdb:4IYF|rcsb pdb:4NIB|rcsb pdb:4OGA|rcsb pdb:4P65|rcsb pdb:4RXW|rcsb pdb:4UNE|rcsb pdb:4UNG|rcsb pdb:4UNH|rcsb pdb:4WDI|rcsb pdb:4XC4|rcsb pdb:4Y19|rcsb pdb:4Y1A|rcsb pdb:4Z76|rcsb pdb:4Z77|rcsb pdb:4Z78|rcsb pdb:5AIY|rcsb pdb:5BOQ|rcsb pdb:5BPO|rcsb pdb:5BQQ|rcsb pdb:5BTS|rcsb pdb:5C0D|rcsb pdb:5CJO|rcsb pdb:5CNY|rcsb pdb:5CO2|rcsb pdb:5CO6|rcsb pdb:5CO9|rcsb pdb:5E7W|rcsb pdb:5EMS|rcsb pdb:5EN9|rcsb pdb:5ENA|rcsb pdb:5HPR|rcsb pdb:5HPU|rcsb pdb:5HQI|rcsb pdb:5HRQ|rcsb pdb:5HYJ|rcsb pdb:5MAM|rcsb pdb:5MHD|rcsb pdb:5MT3|rcsb pdb:5MT9|rcsb pdb:5MWQ|rcsb pdb:5T7R|rcsb pdb:5UDP|rcsb pdb:5UOZ|rcsb pdb:5UQA|rcsb pdb:5URT|rcsb pdb:5URU|rcsb pdb:5USP|rcsb pdb:5USS|rcsb pdb:5USV|rcsb pdb:5UU2|rcsb pdb:5UU3|rcsb pdb:5UU4|rcsb pdb:5VIZ|rcsb pdb:5WBT|rcsb pdb:5WDM|rcsb pdb:5WOB|rcsb pdb:6B3Q|rcsb pdb:6B70|rcsb pdb:6BFC|rcsb pdb:6CE7|rcsb pdb:6CE9|rcsb pdb:6CEB|rcsb pdb:6CK2|rcsb pdb:6GNQ|rcsb pdb:6GV0|rcsb pdb:6H3M|rcsb pdb:6HN5|rcsb pdb:6JR3|rcsb pdb:6K59|rcsb pdb:6NWV|rcsb pdb:6O17|rcsb pdb:6P4Z|rcsb pdb:6S34|rcsb pdb:6S4I|rcsb pdb:6S4J|rcsb pdb:6SOF|rcsb pdb:6TC2|rcsb pdb:6TYH|rcsb pdb:6U46|rcsb pdb:6VEP|rcsb pdb:6VER|rcsb pdb:6VES|rcsb pdb:6VET|rcsb pdb:6X4X|rcsb pdb:6Z7W|rcsb pdb:6Z7Y|rcsb pdb:7BW7|rcsb pdb:7BW8|rcsb pdb:7BWA|rcsb pdb:7NHU|reactome:R-HSA-210745|reactome:R-HSA-264876|reactome:R-HSA-422085|reactome:R-HSA-422356|reactome:R-HSA-6807878|reactome:R-HSA-6811558|reactome:R-HSA-74713|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-74752|reactome:R-HSA-77387|reactome:R-HSA-9615017|reactome:R-HSA-977225|rcsb pdb:6JK8|ensembl:ENSG00000254647(gene)|ensembl:ENST00000250971(transcript)|ensembl:ENST00000381330(transcript)|ensembl:ENST00000397262(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002020"(protease binding)|go:"GO:0002674"(negative regulation of acute inflammatory response)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|refseq:NP_001172026.1|refseq:NP_000198.1|refseq:NP_001172027.1|dip:DIP-6024N	refseq:NP_001278826.1|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005796"(Golgi lumen)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006521"(regulation of cellular amino acid metabolic process)|go:"GO:0006953"(acute-phase response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010750"(positive regulation of nitric oxide mediated signal transduction)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030133"(transport vesicle)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031904"(endosome lumen)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0033861"("negative regulation of NAD(P)H oxidase activity")|go:"GO:0034774"(secretory granule lumen)|go:"GO:0038060"(nitric oxide-cGMP-mediated signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042311"(vasodilation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0045818"(negative regulation of glycogen catabolic process)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045922"(negative regulation of fatty acid metabolic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046631"(alpha-beta T cell activation)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0050890"(cognition)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060266"(negative regulation of respiratory burst involved in inflammatory response)|go:"GO:0060267"(positive regulation of respiratory burst)|go:"GO:0090277"(positive regulation of peptide hormone secretion)|go:"GO:0005179"(hormone activity)|go:"GO:0090336"(positive regulation of brown fat cell differentiation)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|go:"GO:1990535"(neuron projection maintenance)|go:"GO:2000252"(negative regulation of feeding behavior)|interpro:IPR004825(Insulin/IGF/relaxin)|interpro:IPR016179(Insulin-like)|interpro:IPR022352|interpro:IPR022353|interpro:IPR036438|mint:P01308|rcsb pdb:1A7F|rcsb pdb:1AI0|rcsb pdb:1AIY|rcsb pdb:1B9E|rcsb pdb:1BEN|rcsb pdb:1EFE|rcsb pdb:1EV3|rcsb pdb:1EV6|rcsb pdb:1EVR|rcsb pdb:1FU2|rcsb pdb:1FUB|rcsb pdb:1G7A|rcsb pdb:1G7B|rcsb pdb:1GUJ|rcsb pdb:1HIQ|rcsb pdb:1HIS|rcsb pdb:1HIT|rcsb pdb:1HLS|rcsb pdb:1HTV|rcsb pdb:1HUI|rcsb pdb:1IOG|rcsb pdb:1IOH|rcsb pdb:1J73|rcsb pdb:1JCA|rcsb pdb:1JCO|rcsb pdb:1JK8|rcsb pdb:1K3M|rcsb pdb:1KMF|rcsb pdb:1LKQ|rcsb pdb:1LPH|rcsb pdb:1MHI|rcsb pdb:1MHJ|rcsb pdb:1MSO|rcsb pdb:1OS3|rcsb pdb:1OS4|rcsb pdb:1Q4V|rcsb pdb:1QIY|rcsb pdb:1QIZ|rcsb pdb:1QJ0|rcsb pdb:1RWE|rcsb pdb:1SF1|rcsb pdb:1SJT|rcsb pdb:1SJU|rcsb pdb:1T0C|rcsb pdb:1T1K|rcsb pdb:1T1P|rcsb pdb:1T1Q|rcsb pdb:1TRZ|rcsb pdb:1TYL|rcsb pdb:1TYM|rcsb pdb:1UZ9|rcsb pdb:1VKT|rcsb pdb:1W8P|rcsb pdb:1XDA|rcsb pdb:1XGL|rcsb pdb:1XW7|rcsb pdb:1ZEG|rcsb pdb:1ZEH|rcsb pdb:1ZNJ|rcsb pdb:2AIY|rcsb pdb:2C8Q|rcsb pdb:2C8R|rcsb pdb:2CEU|rcsb pdb:2G54|rcsb pdb:2G56|rcsb pdb:2H67|rcsb pdb:2HH4|rcsb pdb:2HHO|rcsb pdb:2HIU|rcsb pdb:2JMN|rcsb pdb:2JUM|rcsb pdb:2JUU|rcsb pdb:2JUV|rcsb pdb:2JZQ|rcsb pdb:2K91|rcsb pdb:2K9R|rcsb pdb:2KJJ|rcsb pdb:2KJU|rcsb pdb:2JV1|rcsb pdb:2KQP|rcsb pdb:2KQQ|rcsb pdb:2KXK|rcsb pdb:2L1Y|rcsb pdb:2L1Z|rcsb pdb:2LGB|rcsb pdb:2LWZ|rcsb pdb:2M1D|rcsb pdb:2M1E|rcsb pdb:2M2M|rcsb pdb:2M2N|rcsb pdb:2M2O|rcsb pdb:2M2P|rcsb pdb:2MLI|rcsb pdb:2MPG|rcsb pdb:2MPI|rcsb pdb:2MVC|rcsb pdb:2MVD|rcsb pdb:2N2V|rcsb pdb:2N2W|rcsb pdb:2N2X|rcsb pdb:2OLY|rcsb pdb:2OLZ|rcsb pdb:2OM0|rcsb pdb:2OM1|rcsb pdb:2OMG|rcsb pdb:2OMH|rcsb pdb:2OMI|rcsb pdb:2OMQ|rcsb pdb:2QIU|rcsb pdb:2R34|rcsb pdb:2R35|rcsb pdb:2R36|rcsb pdb:2RN5|rcsb pdb:2VJZ|rcsb pdb:2VK0|rcsb pdb:2W44|rcsb pdb:2WBY|rcsb pdb:2WC0|rcsb pdb:2WRU|rcsb pdb:2WRV|rcsb pdb:2WRW|rcsb pdb:2WRX|rcsb pdb:2WS0|rcsb pdb:2WS1|rcsb pdb:2WS4|rcsb pdb:2WS6|rcsb pdb:2WS7|rcsb pdb:3AIY|rcsb pdb:3BXQ|rcsb pdb:3E7Y|rcsb pdb:3E7Z|rcsb pdb:3EXX|rcsb pdb:3FQ9|rcsb pdb:3HYD|rcsb pdb:3I3Z|rcsb pdb:3I40|rcsb pdb:3ILG|rcsb pdb:3INC|rcsb pdb:3IR0|rcsb pdb:3JSD|rcsb pdb:3KQ6|rcsb pdb:3P2X|rcsb pdb:3P33|rcsb pdb:3Q6E|rcsb pdb:3ROV|rcsb pdb:3TT8|rcsb pdb:3U4N|rcsb pdb:3UTQ|rcsb pdb:3UTS|rcsb pdb:3UTT|rcsb pdb:3V19|rcsb pdb:3V1G|rcsb pdb:3W11|rcsb pdb:3W12|rcsb pdb:3W13|rcsb pdb:3W7Y|rcsb pdb:3W7Z|rcsb pdb:3W80|rcsb pdb:3ZI3|rcsb pdb:3ZQR|rcsb pdb:3ZS2|rcsb pdb:3ZU1|rcsb pdb:4AIY|rcsb pdb:4AJX|rcsb pdb:4AJZ|rcsb pdb:4AK0|rcsb pdb:4AKJ|rcsb pdb:4CXL|rcsb pdb:4CXN|rcsb pdb:4CY7|rcsb pdb:4EFX|rcsb pdb:4EWW|rcsb pdb:4EWX|rcsb pdb:4EWZ|rcsb pdb:4EX0|rcsb pdb:4EX1|rcsb pdb:4EXX|rcsb pdb:4EY1|rcsb pdb:4EY9|rcsb pdb:4EYD|rcsb pdb:4EYN|rcsb pdb:4EYP|rcsb pdb:4F0N|rcsb pdb:4F0O|rcsb pdb:4F1A|rcsb pdb:4F1B|rcsb pdb:4F1C|rcsb pdb:4F1D|rcsb pdb:4F1F|rcsb pdb:4F1G|rcsb pdb:4F4T|rcsb pdb:4F4V|rcsb pdb:4F51|rcsb pdb:4F8F|rcsb pdb:4FG3|rcsb pdb:4FKA|rcsb pdb:4GBC|rcsb pdb:4GBI|rcsb pdb:4GBK|rcsb pdb:4GBL|rcsb pdb:4GBN|rcsb pdb:4IUZ|rcsb pdb:4IYD|rcsb pdb:4IYF|rcsb pdb:4NIB|rcsb pdb:4OGA|rcsb pdb:4P65|rcsb pdb:4RXW|rcsb pdb:4UNE|rcsb pdb:4UNG|rcsb pdb:4UNH|rcsb pdb:4WDI|rcsb pdb:4XC4|rcsb pdb:4Y19|rcsb pdb:4Y1A|rcsb pdb:4Z76|rcsb pdb:4Z77|rcsb pdb:4Z78|rcsb pdb:5AIY|rcsb pdb:5BOQ|rcsb pdb:5BPO|rcsb pdb:5BQQ|rcsb pdb:5BTS|rcsb pdb:5C0D|rcsb pdb:5CJO|rcsb pdb:5CNY|rcsb pdb:5CO2|rcsb pdb:5CO6|rcsb pdb:5CO9|rcsb pdb:5E7W|rcsb pdb:5EMS|rcsb pdb:5EN9|rcsb pdb:5ENA|rcsb pdb:5HPR|rcsb pdb:5HPU|rcsb pdb:5HQI|rcsb pdb:5HRQ|rcsb pdb:5HYJ|rcsb pdb:5MAM|rcsb pdb:5MHD|rcsb pdb:5MT3|rcsb pdb:5MT9|rcsb pdb:5MWQ|rcsb pdb:5T7R|rcsb pdb:5UDP|rcsb pdb:5UOZ|rcsb pdb:5UQA|rcsb pdb:5URT|rcsb pdb:5URU|rcsb pdb:5USP|rcsb pdb:5USS|rcsb pdb:5USV|rcsb pdb:5UU2|rcsb pdb:5UU3|rcsb pdb:5UU4|rcsb pdb:5VIZ|rcsb pdb:5WBT|rcsb pdb:5WDM|rcsb pdb:5WOB|rcsb pdb:6B3Q|rcsb pdb:6B70|rcsb pdb:6BFC|rcsb pdb:6CE7|rcsb pdb:6CE9|rcsb pdb:6CEB|rcsb pdb:6CK2|rcsb pdb:6GNQ|rcsb pdb:6GV0|rcsb pdb:6H3M|rcsb pdb:6HN5|rcsb pdb:6JR3|rcsb pdb:6K59|rcsb pdb:6NWV|rcsb pdb:6O17|rcsb pdb:6P4Z|rcsb pdb:6S34|rcsb pdb:6S4I|rcsb pdb:6S4J|rcsb pdb:6SOF|rcsb pdb:6TC2|rcsb pdb:6TYH|rcsb pdb:6U46|rcsb pdb:6VEP|rcsb pdb:6VER|rcsb pdb:6VES|rcsb pdb:6VET|rcsb pdb:6X4X|rcsb pdb:6Z7W|rcsb pdb:6Z7Y|rcsb pdb:7BW7|rcsb pdb:7BW8|rcsb pdb:7BWA|rcsb pdb:7NHU|reactome:R-HSA-210745|reactome:R-HSA-264876|reactome:R-HSA-422085|reactome:R-HSA-422356|reactome:R-HSA-6807878|reactome:R-HSA-6811558|reactome:R-HSA-74713|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-74752|reactome:R-HSA-77387|reactome:R-HSA-9615017|reactome:R-HSA-977225|rcsb pdb:6JK8|ensembl:ENSG00000254647(gene)|ensembl:ENST00000250971(transcript)|ensembl:ENST00000381330(transcript)|ensembl:ENST00000397262(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002020"(protease binding)|go:"GO:0002674"(negative regulation of acute inflammatory response)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|refseq:NP_001172026.1|refseq:NP_000198.1|refseq:NP_001172027.1|dip:DIP-6024N	psi-mi:"MI:0465"(dip)	function:Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver|comment:mint|comment:homomint|function:"Defects in INS are the cause of familial hyperproinsulinemia [MIM:176730]"	function:Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver|comment:mint|comment:homomint|function:"Defects in INS are the cause of familial hyperproinsulinemia [MIM:176730]"	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:RFnbvRnJ3AIA4j1Se0KPx0RFhD89606	rogid:RFnbvRnJ3AIA4j1Se0KPx0RFhD89606	rigid:EsXC3x5nIMW+mMBAACV+W8932bQ	false	-	-	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)