#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P18509	uniprotkb:P41586-3	intact:EBI-8588930|ensembl:ENSP00000411658|ensembl:ENSP00000462647|intact:MINT-2801501|uniprotkb:B2R7N4|uniprotkb:Q52LQ0	intact:EBI-15635217|ensembl:ENSP00000387335	psi-mi:paca_human(display_long)|uniprotkb:ADCYAP1(gene name)|psi-mi:ADCYAP1(display_short)	psi-mi:p41586-3(display_long)|uniprotkb:ADCYAP1R1(gene name)|psi-mi:ADCYAP1R1(display_short)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Sun et al. (2007)	pubmed:17470806|doi:10.1073/pnas.0611397104|imex:IM-22820	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15635222|imex:IM-22820-1|dip:DIP-196847E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000141433(gene)|ensembl:ENST00000450565(transcript)|ensembl:ENST00000579794(transcript)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001821"(histamine secretion)|go:"GO:0002865"(negative regulation of acute inflammatory response to antigenic stimulus)|go:"GO:0001662"(behavioral fear response)|go:"GO:0002878"(negative regulation of acute inflammatory response to non-antigenic stimulus)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005184"(neuropeptide hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007565"(female pregnancy)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016521"(pituitary adenylate cyclase activating polypeptide activity)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030073"(insulin secretion)|go:"GO:0031175"(neuron projection development)|go:"GO:0031858"(pituitary adenylate cyclase-activating polypeptide receptor binding)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042311"(vasodilation)|go:"GO:0042594"(response to starvation)|go:"GO:0043005"(neuron projection)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043267"(negative regulation of potassium ion transport)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043950"(positive regulation of cAMP-mediated signaling)|go:"GO:0045471"(response to ethanol)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0060078"(regulation of postsynaptic membrane potential)|go:"GO:0060124"(positive regulation of growth hormone secretion)|go:"GO:0060253"(negative regulation of glial cell proliferation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0070445"(regulation of oligodendrocyte progenitor proliferation)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0071651"("positive regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0090274"(positive regulation of somatostatin secretion)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR000532(Glucagon/GIP/secretin/VIP)|interpro:IPR039080|rcsb pdb:1GEA|rcsb pdb:2D2P|rcsb pdb:2JOD|rcsb pdb:6LPB|rcsb pdb:6M1I|rcsb pdb:6P9Y|rcsb pdb:6VN7|reactome:R-HSA-187024|reactome:R-HSA-418555|reactome:R-HSA-420092|reactome:R-HSA-9660821|dip:DIP-60936N|refseq:NP_001093203.1|refseq:NP_001108.2	intact:EBI-7466402(isoform-parent)|ensembl:ENSG00000078549(gene)|ensembl:ENST00000409363(transcript)	psi-mi:"MI:0465"(dip)	comment:mint|function:Stimulates adenylate cyclase in pituitary cells	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:6aY+rXh6mpnvgTz0F7cAE4Hk3d09606	rogid:hCHO10qnRVj443qGaO0fj1M+JM49606	rigid:EhL14zhRhvJsT854Y5+btOfbAxU	false	sufficient binding region:137-169	sufficient binding region:22-143	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P18509	uniprotkb:P41586-3	intact:EBI-8588930|ensembl:ENSP00000411658|ensembl:ENSP00000462647|intact:MINT-2801501|uniprotkb:B2R7N4|uniprotkb:Q52LQ0	intact:EBI-15635217|ensembl:ENSP00000387335	psi-mi:paca_human(display_long)|uniprotkb:ADCYAP1(gene name)|psi-mi:ADCYAP1(display_short)	psi-mi:p41586-3(display_long)|uniprotkb:ADCYAP1R1(gene name)|psi-mi:ADCYAP1R1(display_short)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Sun et al. (2007)	pubmed:17470806|doi:10.1073/pnas.0611397104|imex:IM-22820	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15635243|imex:IM-22820-2|dip:DIP-196847E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000141433(gene)|ensembl:ENST00000450565(transcript)|ensembl:ENST00000579794(transcript)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001821"(histamine secretion)|go:"GO:0002865"(negative regulation of acute inflammatory response to antigenic stimulus)|go:"GO:0001662"(behavioral fear response)|go:"GO:0002878"(negative regulation of acute inflammatory response to non-antigenic stimulus)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005184"(neuropeptide hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007565"(female pregnancy)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016521"(pituitary adenylate cyclase activating polypeptide activity)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030073"(insulin secretion)|go:"GO:0031175"(neuron projection development)|go:"GO:0031858"(pituitary adenylate cyclase-activating polypeptide receptor binding)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042311"(vasodilation)|go:"GO:0042594"(response to starvation)|go:"GO:0043005"(neuron projection)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043267"(negative regulation of potassium ion transport)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043950"(positive regulation of cAMP-mediated signaling)|go:"GO:0045471"(response to ethanol)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0060078"(regulation of postsynaptic membrane potential)|go:"GO:0060124"(positive regulation of growth hormone secretion)|go:"GO:0060253"(negative regulation of glial cell proliferation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0070445"(regulation of oligodendrocyte progenitor proliferation)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0071651"("positive regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0090274"(positive regulation of somatostatin secretion)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR000532(Glucagon/GIP/secretin/VIP)|interpro:IPR039080|rcsb pdb:1GEA|rcsb pdb:2D2P|rcsb pdb:2JOD|rcsb pdb:6LPB|rcsb pdb:6M1I|rcsb pdb:6P9Y|rcsb pdb:6VN7|reactome:R-HSA-187024|reactome:R-HSA-418555|reactome:R-HSA-420092|reactome:R-HSA-9660821|dip:DIP-60936N|refseq:NP_001093203.1|refseq:NP_001108.2	intact:EBI-7466402(isoform-parent)|ensembl:ENSG00000078549(gene)|ensembl:ENST00000409363(transcript)	psi-mi:"MI:0465"(dip)	comment:mint|function:Stimulates adenylate cyclase in pituitary cells	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:6aY+rXh6mpnvgTz0F7cAE4Hk3d09606	rogid:hCHO10qnRVj443qGaO0fj1M+JM49606	rigid:EhL14zhRhvJsT854Y5+btOfbAxU	false	sufficient binding region:137-169|oregon green label:146-146	sufficient binding region:22-143	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)