#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P16092	uniprotkb:Q99N32	intact:EBI-7953898|uniprotkb:Q60830|uniprotkb:Q01736|uniprotkb:Q8CFK8|intact:MINT-2635590|uniprotkb:Q80T10|uniprotkb:E9Q2P4|uniprotkb:Q61562|uniprotkb:Q9QZM7|ensembl:ENSMUSP00000081041	intact:EBI-15633521|ensembl:ENSMUSP00000031096|uniprotkb:B2RQN8|uniprotkb:Q920J2|uniprotkb:Q99N31	psi-mi:fgfr1_mouse(display_long)|uniprotkb:Fgfr1(gene name)|psi-mi:Fgfr1(display_short)|uniprotkb:Flg(gene name synonym)|uniprotkb:Basic fibroblast growth factor receptor 1(gene name synonym)|uniprotkb:MFR(gene name synonym)|uniprotkb:Proto-oncogene c-Fgr(gene name synonym)	psi-mi:klotb_mouse(display_long)|uniprotkb:Klb(gene name)|psi-mi:Klb(display_short)|uniprotkb:Betakl(gene name synonym)|uniprotkb:Klotho beta-like protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Ogawa et al. (2007)	pubmed:17452648|doi:10.1073/pnas.0701600104|imex:IM-22807	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15633563|imex:IM-22807-1|dip:DIP-196811E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011240423.1|refseq:NP_034336.2|refseq:NP_001073378.1|refseq:NP_001073377.1|refseq:XP_006509073.1|refseq:XP_006509075.1|dip:DIP-6033N|ensembl:ENSMUSG00000031565(gene)|ensembl:ENSMUST00000084027(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001525"(angiogenesis)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001759"(organ induction)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005007"(fibroblast growth factor-activated receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0010966"(regulation of phosphate transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021769"(orbitofrontal cortex development)|go:"GO:0021837"(motogenic signaling involved in postnatal olfactory bulb interneuron migration)|go:"GO:0021847"(ventricular zone neuroblast division)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0030324"(lung development)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030901"(midbrain development)|go:"GO:0031175"(neuron projection development)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035607"(fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042474"(middle ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043583"(ear development)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0010468"(regulation of gene expression)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR028174|interpro:IPR036179|interpro:IPR041159|mint:P16092|rcsb pdb:2CKN|reactome:R-MMU-109704|reactome:R-MMU-1257604|reactome:R-MMU-190370|reactome:R-MMU-190373|reactome:R-MMU-190374|reactome:R-MMU-445144|reactome:R-MMU-5654219|reactome:R-MMU-5654687|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654726|reactome:R-MMU-5673001|reactome:R-MMU-6811558|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048339"(paraxial mesoderm development)|go:"GO:0048378"(regulation of lateral mesodermal cell fate specification)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048699"(generation of neurons)|go:"GO:0048762"(mesenchymal cell differentiation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051174"(regulation of phosphorus metabolic process)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060117"(auditory receptor cell development)|go:"GO:0060445"(branching involved in salivary gland morphogenesis)|go:"GO:0060484"(lung-associated mesenchyme development)|go:"GO:0060665"(regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling)|go:"GO:0060979"(vasculogenesis involved in coronary vascular morphogenesis)|go:"GO:0070640"(vitamin D3 metabolic process)|go:"GO:0072091"(regulation of stem cell proliferation)|go:"GO:0090080"(positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway)|go:"GO:0090272"(negative regulation of fibroblast growth factor production)|go:"GO:0090722"(receptor-receptor interaction)|go:"GO:1903465"(positive regulation of mitotic cell cycle DNA replication)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000491"(positive regulation of hepatic stellate cell activation)|go:"GO:2000546"(positive regulation of endothelial cell chemotaxis to fibroblast growth factor)|go:"GO:2000830"(positive regulation of parathyroid hormone secretion)|go:"GO:2001239"(regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016248(Fibroblast growth factor receptor)	ensembl:ENSMUSG00000029195(gene)|ensembl:ENSMUST00000031096(transcript)|go:"GO:0004553"(hydrolase activity, hydrolyzing O-glycosyl compounds)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0090080"(positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway)|interpro:IPR001360(Glycoside hydrolase, family 1)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR033132|reactome:R-MMU-109704|reactome:R-MMU-1257604|reactome:R-MMU-5654228|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5654720|reactome:R-MMU-5654733|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-1307965|refseq:NP_112457.1|dip:DIP-60918N	psi-mi:"MI:0465"(dip)	comment:mint|function:"Receptor for basic fibroblast growth factor. A shorter form of the receptor could be a receptor for FGF1 (aFGF)"|comment:homomint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/05	2017/08/10	rogid:JSLRQxD7C6jJyldtTkRE1Zn+AvE10090	rogid:XDvsy27xoIfjbnhZiruN1jpSGDQ10090	rigid:tIW1qYzHCfb/UF1/F2sfus5jBKo	false	v5 tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q03142	uniprotkb:Q99N32	intact:EBI-15633599|uniprotkb:Q27Q87|uniprotkb:Q5J7D9|uniprotkb:Q8C3V5|uniprotkb:Q8CIB8	intact:EBI-15633521|ensembl:ENSMUSP00000031096|uniprotkb:B2RQN8|uniprotkb:Q920J2|uniprotkb:Q99N31	psi-mi:fgfr4_mouse(display_long)|uniprotkb:Fgfr4(gene name)|psi-mi:Fgfr4(display_short)|uniprotkb:Fgfr-4(gene name synonym)|uniprotkb:Mpk-11(gene name synonym)|uniprotkb:Protein-tyrosine kinase receptor MPK-11(gene name synonym)	psi-mi:klotb_mouse(display_long)|uniprotkb:Klb(gene name)|psi-mi:Klb(display_short)|uniprotkb:Betakl(gene name synonym)|uniprotkb:Klotho beta-like protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Ogawa et al. (2007)	pubmed:17452648|doi:10.1073/pnas.0701600104|imex:IM-22807	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15633661|imex:IM-22807-3|dip:DIP-196812E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0001759"(organ induction)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005007"(fibroblast growth factor-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010715"(regulation of extracellular matrix disassembly)|go:"GO:0010966"(regulation of phosphate transport)|go:"GO:0016477"(cell migration)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0030133"(transport vesicle)|go:"GO:0030324"(lung development)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051174"(regulation of phosphorus metabolic process)|go:"GO:0055062"(phosphate ion homeostasis)|go:"GO:0061144"(alveolar secondary septum development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070640"(vitamin D3 metabolic process)|go:"GO:0070857"(regulation of bile acid biosynthetic process)|go:"GO:0090272"(negative regulation of fibroblast growth factor production)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2000830"(positive regulation of parathyroid hormone secretion)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016248(Fibroblast growth factor receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036179|reactome:R-MMU-109704|reactome:R-MMU-1257604|reactome:R-MMU-1307965|reactome:R-MMU-190322|reactome:R-MMU-5654228|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5654720|reactome:R-MMU-5654733|reactome:R-MMU-5673001|reactome:R-MMU-6811558|refseq:NP_032037.2|dip:DIP-58508N	ensembl:ENSMUSG00000029195(gene)|ensembl:ENSMUST00000031096(transcript)|go:"GO:0004553"(hydrolase activity, hydrolyzing O-glycosyl compounds)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0090080"(positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway)|interpro:IPR001360(Glycoside hydrolase, family 1)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR033132|reactome:R-MMU-109704|reactome:R-MMU-1257604|reactome:R-MMU-5654228|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5654720|reactome:R-MMU-5654733|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-1307965|refseq:NP_112457.1|dip:DIP-60918N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/05	2017/08/10	rogid:GydxGsNVSaRi7sQhqMDfj6Q7c9I10090	rogid:XDvsy27xoIfjbnhZiruN1jpSGDQ10090	rigid:4hqwL+fJMcpqgTB+rHTzjqHxlhI	false	v5 tag:c-c	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q03142	uniprotkb:Q9JJN1	intact:EBI-15633599|uniprotkb:Q27Q87|uniprotkb:Q5J7D9|uniprotkb:Q8C3V5|uniprotkb:Q8CIB8	intact:EBI-15633680|ensembl:ENSMUSP00000033099	psi-mi:fgfr4_mouse(display_long)|uniprotkb:Fgfr4(gene name)|psi-mi:Fgfr4(display_short)|uniprotkb:Fgfr-4(gene name synonym)|uniprotkb:Mpk-11(gene name synonym)|uniprotkb:Protein-tyrosine kinase receptor MPK-11(gene name synonym)	psi-mi:fgf21_mouse(display_long)|uniprotkb:Fgf21(gene name)|psi-mi:Fgf21(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Ogawa et al. (2007)	pubmed:17452648|doi:10.1073/pnas.0701600104|imex:IM-22807	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15633718|imex:IM-22807-4|dip:DIP-196814E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0001759"(organ induction)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005007"(fibroblast growth factor-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010715"(regulation of extracellular matrix disassembly)|go:"GO:0010966"(regulation of phosphate transport)|go:"GO:0016477"(cell migration)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0030133"(transport vesicle)|go:"GO:0030324"(lung development)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051174"(regulation of phosphorus metabolic process)|go:"GO:0055062"(phosphate ion homeostasis)|go:"GO:0061144"(alveolar secondary septum development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070640"(vitamin D3 metabolic process)|go:"GO:0070857"(regulation of bile acid biosynthetic process)|go:"GO:0090272"(negative regulation of fibroblast growth factor production)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2000830"(positive regulation of parathyroid hormone secretion)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016248(Fibroblast growth factor receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036179|reactome:R-MMU-109704|reactome:R-MMU-1257604|reactome:R-MMU-1307965|reactome:R-MMU-190322|reactome:R-MMU-5654228|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5654720|reactome:R-MMU-5654733|reactome:R-MMU-5673001|reactome:R-MMU-6811558|refseq:NP_032037.2|dip:DIP-58508N	ensembl:ENSMUSG00000030827(gene)|ensembl:ENSMUST00000033099(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010898"(positive regulation of triglyceride catabolic process)|go:"GO:0014823"(response to activity)|go:"GO:0030154"(cell differentiation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0035690"|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071377"(cellular response to glucagon stimulus)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0090080"(positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1904640"(response to methionine)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR002209(Heparin-binding growth factor/Fibroblast growth factor)|interpro:IPR008996(Cytokine, IL-1-like)|interpro:IPR028292|interpro:IPR035444|reactome:R-MMU-189200|refseq:NP_064397.1|refseq:XP_011249181.1|refseq:XP_011249182.1|dip:DIP-60919N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/05	2017/08/10	rogid:GydxGsNVSaRi7sQhqMDfj6Q7c9I10090	rogid:m8VYaqE/53wu8HlxcL+UHVJotuk10090	rigid:alOHZ9Y6hHeytS21RlNibqlnhno	false	v5 tag:c-c	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q03142	uniprotkb:Q99N32	intact:EBI-15633599|uniprotkb:Q27Q87|uniprotkb:Q5J7D9|uniprotkb:Q8C3V5|uniprotkb:Q8CIB8	intact:EBI-15633521|ensembl:ENSMUSP00000031096|uniprotkb:B2RQN8|uniprotkb:Q920J2|uniprotkb:Q99N31	psi-mi:fgfr4_mouse(display_long)|uniprotkb:Fgfr4(gene name)|psi-mi:Fgfr4(display_short)|uniprotkb:Fgfr-4(gene name synonym)|uniprotkb:Mpk-11(gene name synonym)|uniprotkb:Protein-tyrosine kinase receptor MPK-11(gene name synonym)	psi-mi:klotb_mouse(display_long)|uniprotkb:Klb(gene name)|psi-mi:Klb(display_short)|uniprotkb:Betakl(gene name synonym)|uniprotkb:Klotho beta-like protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Ogawa et al. (2007)	pubmed:17452648|doi:10.1073/pnas.0701600104|imex:IM-22807	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15633718|imex:IM-22807-4|dip:DIP-196814E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0001759"(organ induction)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005007"(fibroblast growth factor-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010715"(regulation of extracellular matrix disassembly)|go:"GO:0010966"(regulation of phosphate transport)|go:"GO:0016477"(cell migration)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0030133"(transport vesicle)|go:"GO:0030324"(lung development)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051174"(regulation of phosphorus metabolic process)|go:"GO:0055062"(phosphate ion homeostasis)|go:"GO:0061144"(alveolar secondary septum development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070640"(vitamin D3 metabolic process)|go:"GO:0070857"(regulation of bile acid biosynthetic process)|go:"GO:0090272"(negative regulation of fibroblast growth factor production)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2000830"(positive regulation of parathyroid hormone secretion)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016248(Fibroblast growth factor receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036179|reactome:R-MMU-109704|reactome:R-MMU-1257604|reactome:R-MMU-1307965|reactome:R-MMU-190322|reactome:R-MMU-5654228|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5654720|reactome:R-MMU-5654733|reactome:R-MMU-5673001|reactome:R-MMU-6811558|refseq:NP_032037.2|dip:DIP-58508N	ensembl:ENSMUSG00000029195(gene)|ensembl:ENSMUST00000031096(transcript)|go:"GO:0004553"(hydrolase activity, hydrolyzing O-glycosyl compounds)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0090080"(positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway)|interpro:IPR001360(Glycoside hydrolase, family 1)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR033132|reactome:R-MMU-109704|reactome:R-MMU-1257604|reactome:R-MMU-5654228|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5654720|reactome:R-MMU-5654733|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-1307965|refseq:NP_112457.1|dip:DIP-60918N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/05	2017/08/10	rogid:GydxGsNVSaRi7sQhqMDfj6Q7c9I10090	rogid:XDvsy27xoIfjbnhZiruN1jpSGDQ10090	rigid:alOHZ9Y6hHeytS21RlNibqlnhno	false	v5 tag:c-c	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P16092	uniprotkb:Q99N32	intact:EBI-7953898|uniprotkb:Q60830|uniprotkb:Q01736|uniprotkb:Q8CFK8|intact:MINT-2635590|uniprotkb:Q80T10|uniprotkb:E9Q2P4|uniprotkb:Q61562|uniprotkb:Q9QZM7|ensembl:ENSMUSP00000081041	intact:EBI-15633521|ensembl:ENSMUSP00000031096|uniprotkb:B2RQN8|uniprotkb:Q920J2|uniprotkb:Q99N31	psi-mi:fgfr1_mouse(display_long)|uniprotkb:Fgfr1(gene name)|psi-mi:Fgfr1(display_short)|uniprotkb:Flg(gene name synonym)|uniprotkb:Basic fibroblast growth factor receptor 1(gene name synonym)|uniprotkb:MFR(gene name synonym)|uniprotkb:Proto-oncogene c-Fgr(gene name synonym)	psi-mi:klotb_mouse(display_long)|uniprotkb:Klb(gene name)|psi-mi:Klb(display_short)|uniprotkb:Betakl(gene name synonym)|uniprotkb:Klotho beta-like protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Ogawa et al. (2007)	pubmed:17452648|doi:10.1073/pnas.0701600104|imex:IM-22807	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15633582|imex:IM-22807-2|dip:DIP-196811E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011240423.1|refseq:NP_034336.2|refseq:NP_001073378.1|refseq:NP_001073377.1|refseq:XP_006509073.1|refseq:XP_006509075.1|dip:DIP-6033N|ensembl:ENSMUSG00000031565(gene)|ensembl:ENSMUST00000084027(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001525"(angiogenesis)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001759"(organ induction)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005007"(fibroblast growth factor-activated receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0010966"(regulation of phosphate transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021769"(orbitofrontal cortex development)|go:"GO:0021837"(motogenic signaling involved in postnatal olfactory bulb interneuron migration)|go:"GO:0021847"(ventricular zone neuroblast division)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0030324"(lung development)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030901"(midbrain development)|go:"GO:0031175"(neuron projection development)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035607"(fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042474"(middle ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043583"(ear development)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0010468"(regulation of gene expression)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR028174|interpro:IPR036179|interpro:IPR041159|mint:P16092|rcsb pdb:2CKN|reactome:R-MMU-109704|reactome:R-MMU-1257604|reactome:R-MMU-190370|reactome:R-MMU-190373|reactome:R-MMU-190374|reactome:R-MMU-445144|reactome:R-MMU-5654219|reactome:R-MMU-5654687|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654726|reactome:R-MMU-5673001|reactome:R-MMU-6811558|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048339"(paraxial mesoderm development)|go:"GO:0048378"(regulation of lateral mesodermal cell fate specification)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048699"(generation of neurons)|go:"GO:0048762"(mesenchymal cell differentiation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051174"(regulation of phosphorus metabolic process)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060117"(auditory receptor cell development)|go:"GO:0060445"(branching involved in salivary gland morphogenesis)|go:"GO:0060484"(lung-associated mesenchyme development)|go:"GO:0060665"(regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling)|go:"GO:0060979"(vasculogenesis involved in coronary vascular morphogenesis)|go:"GO:0070640"(vitamin D3 metabolic process)|go:"GO:0072091"(regulation of stem cell proliferation)|go:"GO:0090080"(positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway)|go:"GO:0090272"(negative regulation of fibroblast growth factor production)|go:"GO:0090722"(receptor-receptor interaction)|go:"GO:1903465"(positive regulation of mitotic cell cycle DNA replication)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000491"(positive regulation of hepatic stellate cell activation)|go:"GO:2000546"(positive regulation of endothelial cell chemotaxis to fibroblast growth factor)|go:"GO:2000830"(positive regulation of parathyroid hormone secretion)|go:"GO:2001239"(regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016248(Fibroblast growth factor receptor)	ensembl:ENSMUSG00000029195(gene)|ensembl:ENSMUST00000031096(transcript)|go:"GO:0004553"(hydrolase activity, hydrolyzing O-glycosyl compounds)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0090080"(positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway)|interpro:IPR001360(Glycoside hydrolase, family 1)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR033132|reactome:R-MMU-109704|reactome:R-MMU-1257604|reactome:R-MMU-5654228|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5654720|reactome:R-MMU-5654733|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-1307965|refseq:NP_112457.1|dip:DIP-60918N	psi-mi:"MI:0465"(dip)	comment:mint|function:"Receptor for basic fibroblast growth factor. A shorter form of the receptor could be a receptor for FGF1 (aFGF)"|comment:homomint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/05	2017/08/10	rogid:JSLRQxD7C6jJyldtTkRE1Zn+AvE10090	rogid:XDvsy27xoIfjbnhZiruN1jpSGDQ10090	rigid:tIW1qYzHCfb/UF1/F2sfus5jBKo	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P16092	uniprotkb:Q9JJN1	intact:EBI-7953898|uniprotkb:Q60830|uniprotkb:Q01736|uniprotkb:Q8CFK8|intact:MINT-2635590|uniprotkb:Q80T10|uniprotkb:E9Q2P4|uniprotkb:Q61562|uniprotkb:Q9QZM7|ensembl:ENSMUSP00000081041	intact:EBI-15633680|ensembl:ENSMUSP00000033099	psi-mi:fgfr1_mouse(display_long)|uniprotkb:Fgfr1(gene name)|psi-mi:Fgfr1(display_short)|uniprotkb:Flg(gene name synonym)|uniprotkb:Basic fibroblast growth factor receptor 1(gene name synonym)|uniprotkb:MFR(gene name synonym)|uniprotkb:Proto-oncogene c-Fgr(gene name synonym)	psi-mi:fgf21_mouse(display_long)|uniprotkb:Fgf21(gene name)|psi-mi:Fgf21(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Ogawa et al. (2007)	pubmed:17452648|doi:10.1073/pnas.0701600104|imex:IM-22807	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15633738|imex:IM-22807-5|dip:DIP-196813E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011240423.1|refseq:NP_034336.2|refseq:NP_001073378.1|refseq:NP_001073377.1|refseq:XP_006509073.1|refseq:XP_006509075.1|dip:DIP-6033N|ensembl:ENSMUSG00000031565(gene)|ensembl:ENSMUST00000084027(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001525"(angiogenesis)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001759"(organ induction)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005007"(fibroblast growth factor-activated receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0010966"(regulation of phosphate transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021769"(orbitofrontal cortex development)|go:"GO:0021837"(motogenic signaling involved in postnatal olfactory bulb interneuron migration)|go:"GO:0021847"(ventricular zone neuroblast division)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0030324"(lung development)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030901"(midbrain development)|go:"GO:0031175"(neuron projection development)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035607"(fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042474"(middle ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043583"(ear development)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0010468"(regulation of gene expression)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR028174|interpro:IPR036179|interpro:IPR041159|mint:P16092|rcsb pdb:2CKN|reactome:R-MMU-109704|reactome:R-MMU-1257604|reactome:R-MMU-190370|reactome:R-MMU-190373|reactome:R-MMU-190374|reactome:R-MMU-445144|reactome:R-MMU-5654219|reactome:R-MMU-5654687|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654726|reactome:R-MMU-5673001|reactome:R-MMU-6811558|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048339"(paraxial mesoderm development)|go:"GO:0048378"(regulation of lateral mesodermal cell fate specification)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048699"(generation of neurons)|go:"GO:0048762"(mesenchymal cell differentiation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051174"(regulation of phosphorus metabolic process)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060117"(auditory receptor cell development)|go:"GO:0060445"(branching involved in salivary gland morphogenesis)|go:"GO:0060484"(lung-associated mesenchyme development)|go:"GO:0060665"(regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling)|go:"GO:0060979"(vasculogenesis involved in coronary vascular morphogenesis)|go:"GO:0070640"(vitamin D3 metabolic process)|go:"GO:0072091"(regulation of stem cell proliferation)|go:"GO:0090080"(positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway)|go:"GO:0090272"(negative regulation of fibroblast growth factor production)|go:"GO:0090722"(receptor-receptor interaction)|go:"GO:1903465"(positive regulation of mitotic cell cycle DNA replication)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000491"(positive regulation of hepatic stellate cell activation)|go:"GO:2000546"(positive regulation of endothelial cell chemotaxis to fibroblast growth factor)|go:"GO:2000830"(positive regulation of parathyroid hormone secretion)|go:"GO:2001239"(regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016248(Fibroblast growth factor receptor)	ensembl:ENSMUSG00000030827(gene)|ensembl:ENSMUST00000033099(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010898"(positive regulation of triglyceride catabolic process)|go:"GO:0014823"(response to activity)|go:"GO:0030154"(cell differentiation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0035690"|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071377"(cellular response to glucagon stimulus)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0090080"(positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1904640"(response to methionine)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR002209(Heparin-binding growth factor/Fibroblast growth factor)|interpro:IPR008996(Cytokine, IL-1-like)|interpro:IPR028292|interpro:IPR035444|reactome:R-MMU-189200|refseq:NP_064397.1|refseq:XP_011249181.1|refseq:XP_011249182.1|dip:DIP-60919N	psi-mi:"MI:0465"(dip)	comment:mint|function:"Receptor for basic fibroblast growth factor. A shorter form of the receptor could be a receptor for FGF1 (aFGF)"|comment:homomint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/05	2017/08/10	rogid:JSLRQxD7C6jJyldtTkRE1Zn+AvE10090	rogid:m8VYaqE/53wu8HlxcL+UHVJotuk10090	rigid:/8RDKhJpu/GuNkTZ49McTtyNmT0	false	v5 tag:c-c	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P16092	uniprotkb:Q99N32	intact:EBI-7953898|uniprotkb:Q60830|uniprotkb:Q01736|uniprotkb:Q8CFK8|intact:MINT-2635590|uniprotkb:Q80T10|uniprotkb:E9Q2P4|uniprotkb:Q61562|uniprotkb:Q9QZM7|ensembl:ENSMUSP00000081041	intact:EBI-15633521|ensembl:ENSMUSP00000031096|uniprotkb:B2RQN8|uniprotkb:Q920J2|uniprotkb:Q99N31	psi-mi:fgfr1_mouse(display_long)|uniprotkb:Fgfr1(gene name)|psi-mi:Fgfr1(display_short)|uniprotkb:Flg(gene name synonym)|uniprotkb:Basic fibroblast growth factor receptor 1(gene name synonym)|uniprotkb:MFR(gene name synonym)|uniprotkb:Proto-oncogene c-Fgr(gene name synonym)	psi-mi:klotb_mouse(display_long)|uniprotkb:Klb(gene name)|psi-mi:Klb(display_short)|uniprotkb:Betakl(gene name synonym)|uniprotkb:Klotho beta-like protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Ogawa et al. (2007)	pubmed:17452648|doi:10.1073/pnas.0701600104|imex:IM-22807	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15633738|imex:IM-22807-5|dip:DIP-196813E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011240423.1|refseq:NP_034336.2|refseq:NP_001073378.1|refseq:NP_001073377.1|refseq:XP_006509073.1|refseq:XP_006509075.1|dip:DIP-6033N|ensembl:ENSMUSG00000031565(gene)|ensembl:ENSMUST00000084027(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001525"(angiogenesis)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001759"(organ induction)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005007"(fibroblast growth factor-activated receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0010966"(regulation of phosphate transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021769"(orbitofrontal cortex development)|go:"GO:0021837"(motogenic signaling involved in postnatal olfactory bulb interneuron migration)|go:"GO:0021847"(ventricular zone neuroblast division)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0030324"(lung development)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030901"(midbrain development)|go:"GO:0031175"(neuron projection development)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035607"(fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042474"(middle ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043583"(ear development)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0010468"(regulation of gene expression)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR028174|interpro:IPR036179|interpro:IPR041159|mint:P16092|rcsb pdb:2CKN|reactome:R-MMU-109704|reactome:R-MMU-1257604|reactome:R-MMU-190370|reactome:R-MMU-190373|reactome:R-MMU-190374|reactome:R-MMU-445144|reactome:R-MMU-5654219|reactome:R-MMU-5654687|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654726|reactome:R-MMU-5673001|reactome:R-MMU-6811558|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048339"(paraxial mesoderm development)|go:"GO:0048378"(regulation of lateral mesodermal cell fate specification)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048699"(generation of neurons)|go:"GO:0048762"(mesenchymal cell differentiation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051174"(regulation of phosphorus metabolic process)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060117"(auditory receptor cell development)|go:"GO:0060445"(branching involved in salivary gland morphogenesis)|go:"GO:0060484"(lung-associated mesenchyme development)|go:"GO:0060665"(regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling)|go:"GO:0060979"(vasculogenesis involved in coronary vascular morphogenesis)|go:"GO:0070640"(vitamin D3 metabolic process)|go:"GO:0072091"(regulation of stem cell proliferation)|go:"GO:0090080"(positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway)|go:"GO:0090272"(negative regulation of fibroblast growth factor production)|go:"GO:0090722"(receptor-receptor interaction)|go:"GO:1903465"(positive regulation of mitotic cell cycle DNA replication)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000491"(positive regulation of hepatic stellate cell activation)|go:"GO:2000546"(positive regulation of endothelial cell chemotaxis to fibroblast growth factor)|go:"GO:2000830"(positive regulation of parathyroid hormone secretion)|go:"GO:2001239"(regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016248(Fibroblast growth factor receptor)	ensembl:ENSMUSG00000029195(gene)|ensembl:ENSMUST00000031096(transcript)|go:"GO:0004553"(hydrolase activity, hydrolyzing O-glycosyl compounds)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0090080"(positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway)|interpro:IPR001360(Glycoside hydrolase, family 1)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR033132|reactome:R-MMU-109704|reactome:R-MMU-1257604|reactome:R-MMU-5654228|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5654720|reactome:R-MMU-5654733|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-1307965|refseq:NP_112457.1|dip:DIP-60918N	psi-mi:"MI:0465"(dip)	comment:mint|function:"Receptor for basic fibroblast growth factor. A shorter form of the receptor could be a receptor for FGF1 (aFGF)"|comment:homomint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/05	2017/08/10	rogid:JSLRQxD7C6jJyldtTkRE1Zn+AvE10090	rogid:XDvsy27xoIfjbnhZiruN1jpSGDQ10090	rigid:/8RDKhJpu/GuNkTZ49McTtyNmT0	false	v5 tag:c-c	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)