#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q64385 uniprotkb:Q64385 intact:EBI-15632053|ensembl:ENSMUSP00000095736|ensembl:ENSMUSP00000103675|ensembl:ENSMUSP00000103676|ensembl:ENSMUSP00000103677|uniprotkb:A2AMS4|uniprotkb:Q6NSQ0 intact:EBI-15632053|ensembl:ENSMUSP00000095736|ensembl:ENSMUSP00000103675|ensembl:ENSMUSP00000103676|ensembl:ENSMUSP00000103677|uniprotkb:A2AMS4|uniprotkb:Q6NSQ0 psi-mi:i11ra_mouse(display_long)|uniprotkb:Enhancer trap locus homolog 2(gene name synonym)|uniprotkb:Il11ra1(gene name)|psi-mi:Il11ra1(display_short)|uniprotkb:Etl2(gene name synonym)|uniprotkb:Il11ra(gene name synonym)|uniprotkb:Novel cytokine receptor 1(gene name synonym) psi-mi:i11ra_mouse(display_long)|uniprotkb:Enhancer trap locus homolog 2(gene name synonym)|uniprotkb:Il11ra1(gene name)|psi-mi:Il11ra1(display_short)|uniprotkb:Etl2(gene name synonym)|uniprotkb:Il11ra(gene name synonym)|uniprotkb:Novel cytokine receptor 1(gene name synonym) psi-mi:"MI:0410"(3D electron microscopy) Matadeen et al. (2007) pubmed:17437716|doi:10.1016/j.str.2007.02.006|imex:IM-8735 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15632095|imex:IM-8735-1|dip:DIP-58805E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000073889(gene)|ensembl:ENSMUST00000098132(transcript)|ensembl:ENSMUST00000108040(transcript)|ensembl:ENSMUST00000108041(transcript)|ensembl:ENSMUST00000108042(transcript)|go:"GO:0001779"(natural killer cell differentiation)|go:"GO:0001890"(placenta development)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004921"(interleukin-11 receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0019970"(interleukin-11 binding)|go:"GO:0032502"(developmental process)|go:"GO:0043235"(receptor complex)|go:"GO:0046697"(decidualization)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0060322"(head development)|interpro:IPR003530(Long hematopoietin receptor, soluble alpha chain, conserved site)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR036179|reactome:R-MMU-6788467|refseq:NP_001156873.1|refseq:NP_001165525.1|refseq:NP_034679.1|dip:DIP-5781N ensembl:ENSMUSG00000073889(gene)|ensembl:ENSMUST00000098132(transcript)|ensembl:ENSMUST00000108040(transcript)|ensembl:ENSMUST00000108041(transcript)|ensembl:ENSMUST00000108042(transcript)|go:"GO:0001779"(natural killer cell differentiation)|go:"GO:0001890"(placenta development)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004921"(interleukin-11 receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0019970"(interleukin-11 binding)|go:"GO:0032502"(developmental process)|go:"GO:0043235"(receptor complex)|go:"GO:0046697"(decidualization)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0060322"(head development)|interpro:IPR003530(Long hematopoietin receptor, soluble alpha chain, conserved site)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR036179|reactome:R-MMU-6788467|refseq:NP_001156873.1|refseq:NP_001165525.1|refseq:NP_034679.1|dip:DIP-5781N psi-mi:"MI:0465"(dip) - - caution:[EBI-12797107] The protein has been merged with EBI-12717024 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/11 rogid:jRH9SQzQS1P5wiZzxgNWXzjyF6c10090 rogid:jRH9SQzQS1P5wiZzxgNWXzjyF6c10090 rigid:uPrYUuJEAN0mZ2Qn1mKC4qZaJ98 false sufficient binding region:1-361 sufficient binding region:1-361 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q64385 uniprotkb:P47873 intact:EBI-15632053|ensembl:ENSMUSP00000095736|ensembl:ENSMUSP00000103675|ensembl:ENSMUSP00000103676|ensembl:ENSMUSP00000103677|uniprotkb:A2AMS4|uniprotkb:Q6NSQ0 intact:EBI-15632028|ensembl:ENSMUSP00000092492 psi-mi:i11ra_mouse(display_long)|uniprotkb:Enhancer trap locus homolog 2(gene name synonym)|uniprotkb:Il11ra1(gene name)|psi-mi:Il11ra1(display_short)|uniprotkb:Etl2(gene name synonym)|uniprotkb:Il11ra(gene name synonym)|uniprotkb:Novel cytokine receptor 1(gene name synonym) psi-mi:il11_mouse(display_long)|uniprotkb:Il11(gene name)|psi-mi:Il11(display_short) psi-mi:"MI:0410"(3D electron microscopy) Matadeen et al. (2007) pubmed:17437716|doi:10.1016/j.str.2007.02.006|imex:IM-8735 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15632095|imex:IM-8735-1|dip:DIP-58805E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000073889(gene)|ensembl:ENSMUST00000098132(transcript)|ensembl:ENSMUST00000108040(transcript)|ensembl:ENSMUST00000108041(transcript)|ensembl:ENSMUST00000108042(transcript)|go:"GO:0001779"(natural killer cell differentiation)|go:"GO:0001890"(placenta development)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004921"(interleukin-11 receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0019970"(interleukin-11 binding)|go:"GO:0032502"(developmental process)|go:"GO:0043235"(receptor complex)|go:"GO:0046697"(decidualization)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0060322"(head development)|interpro:IPR003530(Long hematopoietin receptor, soluble alpha chain, conserved site)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR036179|reactome:R-MMU-6788467|refseq:NP_001156873.1|refseq:NP_001165525.1|refseq:NP_034679.1|dip:DIP-5781N ensembl:ENSMUSG00000004371(gene)|ensembl:ENSMUST00000094892(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005142"(interleukin-11 receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR020412|interpro:IPR020438|reactome:R-MMU-6788467|refseq:NP_032376.1|dip:DIP-5780N psi-mi:"MI:0465"(dip) - - caution:[EBI-12797107] The protein has been merged with EBI-12717024 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/11 rogid:jRH9SQzQS1P5wiZzxgNWXzjyF6c10090 rogid:J1hx5NBDQwYQpYfoHTjzrQikZfQ10090 rigid:uPrYUuJEAN0mZ2Qn1mKC4qZaJ98 false sufficient binding region:1-361 sufficient binding region:22-199 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q64385 uniprotkb:P47873 intact:EBI-15632053|ensembl:ENSMUSP00000095736|ensembl:ENSMUSP00000103675|ensembl:ENSMUSP00000103676|ensembl:ENSMUSP00000103677|uniprotkb:A2AMS4|uniprotkb:Q6NSQ0 intact:EBI-15632028|ensembl:ENSMUSP00000092492 psi-mi:i11ra_mouse(display_long)|uniprotkb:Enhancer trap locus homolog 2(gene name synonym)|uniprotkb:Il11ra1(gene name)|psi-mi:Il11ra1(display_short)|uniprotkb:Etl2(gene name synonym)|uniprotkb:Il11ra(gene name synonym)|uniprotkb:Novel cytokine receptor 1(gene name synonym) psi-mi:il11_mouse(display_long)|uniprotkb:Il11(gene name)|psi-mi:Il11(display_short) psi-mi:"MI:0410"(3D electron microscopy) Matadeen et al. (2007) pubmed:17437716|doi:10.1016/j.str.2007.02.006|imex:IM-8735 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15632095|imex:IM-8735-1|dip:DIP-58805E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000073889(gene)|ensembl:ENSMUST00000098132(transcript)|ensembl:ENSMUST00000108040(transcript)|ensembl:ENSMUST00000108041(transcript)|ensembl:ENSMUST00000108042(transcript)|go:"GO:0001779"(natural killer cell differentiation)|go:"GO:0001890"(placenta development)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004921"(interleukin-11 receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0019970"(interleukin-11 binding)|go:"GO:0032502"(developmental process)|go:"GO:0043235"(receptor complex)|go:"GO:0046697"(decidualization)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0060322"(head development)|interpro:IPR003530(Long hematopoietin receptor, soluble alpha chain, conserved site)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR036179|reactome:R-MMU-6788467|refseq:NP_001156873.1|refseq:NP_001165525.1|refseq:NP_034679.1|dip:DIP-5781N ensembl:ENSMUSG00000004371(gene)|ensembl:ENSMUST00000094892(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005142"(interleukin-11 receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR020412|interpro:IPR020438|reactome:R-MMU-6788467|refseq:NP_032376.1|dip:DIP-5780N psi-mi:"MI:0465"(dip) - - caution:[EBI-12797107] The protein has been merged with EBI-12717024 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/11 rogid:jRH9SQzQS1P5wiZzxgNWXzjyF6c10090 rogid:J1hx5NBDQwYQpYfoHTjzrQikZfQ10090 rigid:uPrYUuJEAN0mZ2Qn1mKC4qZaJ98 false sufficient binding region:1-361 sufficient binding region:22-199 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q64385 uniprotkb:Q00560 intact:EBI-15632053|ensembl:ENSMUSP00000095736|ensembl:ENSMUSP00000103675|ensembl:ENSMUSP00000103676|ensembl:ENSMUSP00000103677|uniprotkb:A2AMS4|uniprotkb:Q6NSQ0 intact:EBI-3862992|intact:EBI-15596000|uniprotkb:G5E8D2|ensembl:ENSMUSP00000064205|ensembl:ENSMUSP00000138836|ensembl:ENSMUSP00000139227 psi-mi:i11ra_mouse(display_long)|uniprotkb:Enhancer trap locus homolog 2(gene name synonym)|uniprotkb:Il11ra1(gene name)|psi-mi:Il11ra1(display_short)|uniprotkb:Etl2(gene name synonym)|uniprotkb:Il11ra(gene name synonym)|uniprotkb:Novel cytokine receptor 1(gene name synonym) psi-mi:il6rb_mouse(display_long)|uniprotkb:Il6st(gene name)|psi-mi:Il6st(display_short)|uniprotkb:Interleukin-6 signal transducer(gene name synonym)|uniprotkb:Membrane glycoprotein 130(gene name synonym)|uniprotkb:Oncostatin-M receptor subunit alpha(gene name synonym) psi-mi:"MI:0410"(3D electron microscopy) Matadeen et al. (2007) pubmed:17437716|doi:10.1016/j.str.2007.02.006|imex:IM-8735 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15632095|imex:IM-8735-1|dip:DIP-58805E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000073889(gene)|ensembl:ENSMUST00000098132(transcript)|ensembl:ENSMUST00000108040(transcript)|ensembl:ENSMUST00000108041(transcript)|ensembl:ENSMUST00000108042(transcript)|go:"GO:0001779"(natural killer cell differentiation)|go:"GO:0001890"(placenta development)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004921"(interleukin-11 receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0019970"(interleukin-11 binding)|go:"GO:0032502"(developmental process)|go:"GO:0043235"(receptor complex)|go:"GO:0046697"(decidualization)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0060322"(head development)|interpro:IPR003530(Long hematopoietin receptor, soluble alpha chain, conserved site)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR036179|reactome:R-MMU-6788467|refseq:NP_001156873.1|refseq:NP_001165525.1|refseq:NP_034679.1|dip:DIP-5781N refseq:NP_034690.3|dip:DIP-5782N|ensembl:ENSMUSG00000021756(gene)|ensembl:ENSMUST00000070731(transcript)|ensembl:ENSMUST00000183663(transcript)|ensembl:ENSMUST00000184311(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004897"(ciliary neurotrophic factor receptor activity)|go:"GO:0004915"(interleukin-6 receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0004924"(oncostatin-M receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005138"(interleukin-6 receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005896"(interleukin-6 receptor complex)|go:"GO:0005900"(oncostatin-M receptor complex)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0006642"(triglyceride mobilization)|go:"GO:0007165"(signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008593"(regulation of Notch signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0019981"(interleukin-6 binding)|go:"GO:0030425"(dendrite)|go:"GO:0032809"(neuronal cell body membrane)|go:"GO:0034097"(response to cytokine)|go:"GO:0038154"(interleukin-11-mediated signaling pathway)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0044297"(cell body)|go:"GO:0045121"(membrane raft)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0048861"(leukemia inhibitory factor signaling pathway)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0060576"(intestinal epithelial cell development)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070104"(negative regulation of interleukin-6-mediated signaling pathway)|go:"GO:0070106"(interleukin-27-mediated signaling pathway)|go:"GO:0070110"(ciliary neurotrophic factor receptor complex)|go:"GO:0070120"(ciliary neurotrophic factor-mediated signaling pathway)|go:"GO:0097110"(scaffold protein binding)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR010457(Immunoglobulin C2-set-like, ligand-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015321(Interleukin-6 receptor alpha chain, binding)|interpro:IPR036116|mint:Q00560|rcsb pdb:2BBU|rcsb pdb:2HMH|rcsb pdb:4GL9|rcsb pdb:6C5X|reactome:R-MMU-1059683|reactome:R-MMU-110056|reactome:R-MMU-112411|reactome:R-MMU-6788467|reactome:R-MMU-8984722|reactome:R-MMU-9020956|go:"GO:0042102"(positive regulation of T cell proliferation) psi-mi:"MI:0465"(dip) - - caution:[EBI-12797107] The protein has been merged with EBI-12717024 so the duplicated interactor has been deleted from this interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/11 rogid:jRH9SQzQS1P5wiZzxgNWXzjyF6c10090 rogid:DE0EsnNO+FvIfikpCy6T+Ma372Y10090 rigid:uPrYUuJEAN0mZ2Qn1mKC4qZaJ98 false sufficient binding region:1-361 sufficient binding region:1-617 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)