#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q61143 uniprotkb:Q96D31 intact:EBI-15563578|ensembl:ENSMUSP00000057965|uniprotkb:B9EIW2|uniprotkb:Q9Z2J1 intact:EBI-2291476|uniprotkb:Q3MHV3|uniprotkb:Q6DHX2|uniprotkb:Q96BP7|uniprotkb:Q96K71|ensembl:ENSP00000482568 psi-mi:trpc6_mouse(display_long)|uniprotkb:Trpc6(gene name)|psi-mi:Trpc6(display_short)|uniprotkb:Trp6(gene name synonym)|uniprotkb:Trrp6(gene name synonym)|uniprotkb:Calcium entry channel(gene name synonym)|uniprotkb:Transient receptor protein 6(gene name synonym) psi-mi:crcm1_human(display_long)|uniprotkb:ORAI1(gene name)|psi-mi:ORAI1(display_short)|uniprotkb:CRACM1(gene name synonym)|uniprotkb:TMEM142A(gene name synonym)|uniprotkb:Protein orai-1(gene name synonym)|uniprotkb:Transmembrane protein 142A(gene name synonym) psi-mi:"MI:0096"(pull down) Liao et al. (2007) pubmed:17360584|doi:10.1073/pnas.0611692104|imex:IM-22776 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15627247|imex:IM-22776-1|dip:DIP-196709E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000031997(gene)|ensembl:ENSMUST00000050433(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005216"(ion channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006828"(manganese ion transport)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007338"(single fertilization)|go:"GO:0007568"(aging)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0015279"(store-operated calcium channel activity)|go:"GO:0016020"(membrane)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030276"(clathrin binding)|go:"GO:0032414"(positive regulation of ion transmembrane transporter activity)|go:"GO:0034703"(cation channel complex)|go:"GO:0036057"(slit diaphragm)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042805"(actinin binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0050774"(negative regulation of dendrite morphogenesis)|go:"GO:0051117"(ATPase binding)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0070679"(inositol 1,4,5 trisphosphate binding)|go:"GO:0071456"(cellular response to hypoxia)|interpro:IPR002110(Ankyrin)|interpro:IPR002153(Transient receptor potential protein)|interpro:IPR005462(Transient receptor potential channel 6)|interpro:IPR005821(Ion transport)|interpro:IPR013555(Transient receptor potential II)|interpro:IPR020683|interpro:IPR036770|rcsb pdb:6CV9|reactome:R-MMU-114508|reactome:R-MMU-139853|reactome:R-MMU-3295583|refseq:NP_038866.2|refseq:XP_006509913.1|dip:DIP-60893N refseq:NP_116179.2|go:"GO:0070588"(calcium ion transmembrane transport)|interpro:IPR012446(Protein of unknown function DUF1650)|interpro:IPR038350|rcsb pdb:2MAK|rcsb pdb:4EHQ|reactome:R-HSA-139853|reactome:R-HSA-5578775|reactome:R-HSA-983695|ensembl:ENSG00000276045(gene)|ensembl:ENST00000617316(transcript)|go:"GO:0002115"(store-operated calcium entry)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0015279"(store-operated calcium channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045121"(membrane raft)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0061180"(mammary gland epithelium development)|go:"GO:0070509"(calcium ion import)|dip:DIP-46289N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:hNvHCRgvRF7QFM77G5gWcce0Xc410090 rogid:VXcTrF/8sZA01XGUFZwvu75L7Kw9606 rigid:6fWuYwww7VnGYA73QQT1/2EkzAw false 35s radiolabel:?-? glutathione s tranferase tag:n-n - - psi-mi:"MI:0833"(autoradiography) psi-mi:"MI:0833"(autoradiography) uniprotkb:Q96D31 uniprotkb:Q13507 intact:EBI-2291476|uniprotkb:Q3MHV3|uniprotkb:Q6DHX2|uniprotkb:Q96BP7|uniprotkb:Q96K71|ensembl:ENSP00000482568 intact:EBI-520807|uniprotkb:O00593|uniprotkb:Q15660|uniprotkb:Q52M35|uniprotkb:A7VJS1|uniprotkb:E9PCJ9|uniprotkb:Q5G1L5 psi-mi:crcm1_human(display_long)|uniprotkb:ORAI1(gene name)|psi-mi:ORAI1(display_short)|uniprotkb:CRACM1(gene name synonym)|uniprotkb:TMEM142A(gene name synonym)|uniprotkb:Protein orai-1(gene name synonym)|uniprotkb:Transmembrane protein 142A(gene name synonym) psi-mi:trpc3_human(display_long)|uniprotkb:Transient receptor protein 3(gene name synonym)|uniprotkb:TRPC3(gene name)|psi-mi:TRPC3(display_short)|uniprotkb:TRP3(gene name synonym) psi-mi:"MI:0096"(pull down) Liao et al. (2007) pubmed:17360584|doi:10.1073/pnas.0611692104|imex:IM-22776 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15627268|imex:IM-22776-2|dip:DIP-196708E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_116179.2|go:"GO:0070588"(calcium ion transmembrane transport)|interpro:IPR012446(Protein of unknown function DUF1650)|interpro:IPR038350|rcsb pdb:2MAK|rcsb pdb:4EHQ|reactome:R-HSA-139853|reactome:R-HSA-5578775|reactome:R-HSA-983695|ensembl:ENSG00000276045(gene)|ensembl:ENST00000617316(transcript)|go:"GO:0002115"(store-operated calcium entry)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0015279"(store-operated calcium channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045121"(membrane raft)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0061180"(mammary gland epithelium development)|go:"GO:0070509"(calcium ion import)|dip:DIP-46289N refseq:NP_001124170.1|refseq:NP_003296.1|reactome:R-HSA-114508|reactome:R-HSA-139853|reactome:R-HSA-3295583|reactome:R-HSA-418890|dip:DIP-34311N|reactome:R-HSA-9022699|go:"GO:0005262"(calcium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006828"(manganese ion transport)|go:"GO:0007338"(single fertilization)|go:"GO:0007602"(phototransduction)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0015279"(store-operated calcium channel activity)|go:"GO:0033198"(response to ATP)|go:"GO:0034703"(cation channel complex)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051592"(response to calcium ion)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0070679"(inositol 1,4,5 trisphosphate binding)|go:"GO:1903244"(positive regulation of cardiac muscle hypertrophy in response to stress)|interpro:IPR002110(Ankyrin)|interpro:IPR002153(Transient receptor potential protein)|interpro:IPR005459(Transient receptor potential channel 3)|interpro:IPR005821(Ion transport)|interpro:IPR013555(Transient receptor potential II)|interpro:IPR020683|interpro:IPR036770|rcsb pdb:5ZBG|rcsb pdb:6CUD|rcsb pdb:6D7L|rcsb pdb:6DJS psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:VXcTrF/8sZA01XGUFZwvu75L7Kw9606 rogid:+cpkw8G+u8CX1vRaeVynSg3owOk9606 rigid:UynSZlXxWOCOXGPwLEaBc6T0Tdk false glutathione s tranferase tag:n-n 35s radiolabel:?-? - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BRQ5 uniprotkb:Q13507 intact:EBI-4279484|uniprotkb:Q96BI8|ensembl:ENSP00000322249 intact:EBI-520807|uniprotkb:O00593|uniprotkb:Q15660|uniprotkb:Q52M35|uniprotkb:A7VJS1|uniprotkb:E9PCJ9|uniprotkb:Q5G1L5 psi-mi:orai3_human(display_long)|uniprotkb:ORAI3(gene name)|psi-mi:ORAI3(display_short)|uniprotkb:TMEM142C(gene name synonym)|uniprotkb:Transmembrane protein 142C(gene name synonym) psi-mi:trpc3_human(display_long)|uniprotkb:Transient receptor protein 3(gene name synonym)|uniprotkb:TRPC3(gene name)|psi-mi:TRPC3(display_short)|uniprotkb:TRP3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Liao et al. (2007) pubmed:17360584|doi:10.1073/pnas.0611692104|imex:IM-22776 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15627289|imex:IM-22776-3|dip:DIP-196711E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_689501.1|ensembl:ENST00000318663(transcript)|go:"GO:0002115"(store-operated calcium entry)|go:"GO:0005886"(plasma membrane)|go:"GO:0015279"(store-operated calcium channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR012446(Protein of unknown function DUF1650)|interpro:IPR030032|ensembl:ENSG00000175938(gene)|dip:DIP-48945N refseq:NP_001124170.1|refseq:NP_003296.1|reactome:R-HSA-114508|reactome:R-HSA-139853|reactome:R-HSA-3295583|reactome:R-HSA-418890|dip:DIP-34311N|reactome:R-HSA-9022699|go:"GO:0005262"(calcium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006828"(manganese ion transport)|go:"GO:0007338"(single fertilization)|go:"GO:0007602"(phototransduction)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0015279"(store-operated calcium channel activity)|go:"GO:0033198"(response to ATP)|go:"GO:0034703"(cation channel complex)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051592"(response to calcium ion)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0070679"(inositol 1,4,5 trisphosphate binding)|go:"GO:1903244"(positive regulation of cardiac muscle hypertrophy in response to stress)|interpro:IPR002110(Ankyrin)|interpro:IPR002153(Transient receptor potential protein)|interpro:IPR005459(Transient receptor potential channel 3)|interpro:IPR005821(Ion transport)|interpro:IPR013555(Transient receptor potential II)|interpro:IPR020683|interpro:IPR036770|rcsb pdb:5ZBG|rcsb pdb:6CUD|rcsb pdb:6D7L|rcsb pdb:6DJS psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops) - 2017/08/05 2017/08/10 rogid:kK4e1W0ECdnRSAywrxvpkk89p/89606 rogid:+cpkw8G+u8CX1vRaeVynSg3owOk9606 rigid:byxCoi2aN+LbLsdfrkKen4fqQsA false myc tag:n-n ha tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q96SN7 uniprotkb:Q13507 intact:EBI-714817|uniprotkb:Q6IA68|uniprotkb:Q8WY94|uniprotkb:Q9H9Y3|ensembl:ENSP00000348752|ensembl:ENSP00000385489|ensembl:ENSP00000417928|ensembl:ENSP00000418140|ensembl:ENSP00000418464|ensembl:ENSP00000420178|ensembl:ENSP00000478113 intact:EBI-520807|uniprotkb:O00593|uniprotkb:Q15660|uniprotkb:Q52M35|uniprotkb:A7VJS1|uniprotkb:E9PCJ9|uniprotkb:Q5G1L5 psi-mi:orai2_human(display_long)|uniprotkb:TMEM142B(gene name synonym)|uniprotkb:ORAI2(gene name)|psi-mi:ORAI2(display_short)|uniprotkb:PP1729(orf name)|uniprotkb:C7orf19(gene name synonym)|uniprotkb:CBCIP2(gene name synonym)|uniprotkb:CAP-binding protein complex-interacting protein 2(gene name synonym)|uniprotkb:Transmembrane protein 142B(gene name synonym) psi-mi:trpc3_human(display_long)|uniprotkb:Transient receptor protein 3(gene name synonym)|uniprotkb:TRPC3(gene name)|psi-mi:TRPC3(display_short)|uniprotkb:TRP3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Liao et al. (2007) pubmed:17360584|doi:10.1073/pnas.0611692104|imex:IM-22776 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15627310|imex:IM-22776-4|dip:DIP-196710E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000160991(gene)|ensembl:ENST00000356387(transcript)|ensembl:ENST00000403646(transcript)|ensembl:ENST00000478730(transcript)|ensembl:ENST00000495936(transcript)|ensembl:ENST00000498661(transcript)|ensembl:ENST00000611770(transcript)|go:"GO:0002115"(store-operated calcium entry)|go:"GO:0015279"(store-operated calcium channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR012446(Protein of unknown function DUF1650)|interpro:IPR030034|interpro:IPR038350|reactome:R-HSA-139853|reactome:R-HSA-5578775|reactome:R-HSA-983695|ensembl:ENST00000473939(transcript)|refseq:NP_001119812.1|refseq:NP_116220.1|refseq:NP_001258747.1|dip:DIP-48944N refseq:NP_001124170.1|refseq:NP_003296.1|reactome:R-HSA-114508|reactome:R-HSA-139853|reactome:R-HSA-3295583|reactome:R-HSA-418890|dip:DIP-34311N|reactome:R-HSA-9022699|go:"GO:0005262"(calcium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006828"(manganese ion transport)|go:"GO:0007338"(single fertilization)|go:"GO:0007602"(phototransduction)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0015279"(store-operated calcium channel activity)|go:"GO:0033198"(response to ATP)|go:"GO:0034703"(cation channel complex)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051592"(response to calcium ion)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0070679"(inositol 1,4,5 trisphosphate binding)|go:"GO:1903244"(positive regulation of cardiac muscle hypertrophy in response to stress)|interpro:IPR002110(Ankyrin)|interpro:IPR002153(Transient receptor potential protein)|interpro:IPR005459(Transient receptor potential channel 3)|interpro:IPR005821(Ion transport)|interpro:IPR013555(Transient receptor potential II)|interpro:IPR020683|interpro:IPR036770|rcsb pdb:5ZBG|rcsb pdb:6CUD|rcsb pdb:6D7L|rcsb pdb:6DJS psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops) - 2017/08/05 2017/08/10 rogid:vch80zTIaj1OmGLhPD6/mUe6a749606 rogid:+cpkw8G+u8CX1vRaeVynSg3owOk9606 rigid:qMHrryRcRhcReS3X1LVubl/q7e4 false myc tag:n-n ha tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q96D31 uniprotkb:Q13507 intact:EBI-2291476|uniprotkb:Q3MHV3|uniprotkb:Q6DHX2|uniprotkb:Q96BP7|uniprotkb:Q96K71|ensembl:ENSP00000482568 intact:EBI-520807|uniprotkb:O00593|uniprotkb:Q15660|uniprotkb:Q52M35|uniprotkb:A7VJS1|uniprotkb:E9PCJ9|uniprotkb:Q5G1L5 psi-mi:crcm1_human(display_long)|uniprotkb:ORAI1(gene name)|psi-mi:ORAI1(display_short)|uniprotkb:CRACM1(gene name synonym)|uniprotkb:TMEM142A(gene name synonym)|uniprotkb:Protein orai-1(gene name synonym)|uniprotkb:Transmembrane protein 142A(gene name synonym) psi-mi:trpc3_human(display_long)|uniprotkb:Transient receptor protein 3(gene name synonym)|uniprotkb:TRPC3(gene name)|psi-mi:TRPC3(display_short)|uniprotkb:TRP3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Liao et al. (2007) pubmed:17360584|doi:10.1073/pnas.0611692104|imex:IM-22776 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15627331|imex:IM-22776-5|dip:DIP-196708E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_116179.2|go:"GO:0070588"(calcium ion transmembrane transport)|interpro:IPR012446(Protein of unknown function DUF1650)|interpro:IPR038350|rcsb pdb:2MAK|rcsb pdb:4EHQ|reactome:R-HSA-139853|reactome:R-HSA-5578775|reactome:R-HSA-983695|ensembl:ENSG00000276045(gene)|ensembl:ENST00000617316(transcript)|go:"GO:0002115"(store-operated calcium entry)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0015279"(store-operated calcium channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045121"(membrane raft)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0061180"(mammary gland epithelium development)|go:"GO:0070509"(calcium ion import)|dip:DIP-46289N refseq:NP_001124170.1|refseq:NP_003296.1|reactome:R-HSA-114508|reactome:R-HSA-139853|reactome:R-HSA-3295583|reactome:R-HSA-418890|dip:DIP-34311N|reactome:R-HSA-9022699|go:"GO:0005262"(calcium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006828"(manganese ion transport)|go:"GO:0007338"(single fertilization)|go:"GO:0007602"(phototransduction)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0015279"(store-operated calcium channel activity)|go:"GO:0033198"(response to ATP)|go:"GO:0034703"(cation channel complex)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051592"(response to calcium ion)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0070679"(inositol 1,4,5 trisphosphate binding)|go:"GO:1903244"(positive regulation of cardiac muscle hypertrophy in response to stress)|interpro:IPR002110(Ankyrin)|interpro:IPR002153(Transient receptor potential protein)|interpro:IPR005459(Transient receptor potential channel 3)|interpro:IPR005821(Ion transport)|interpro:IPR013555(Transient receptor potential II)|interpro:IPR020683|interpro:IPR036770|rcsb pdb:5ZBG|rcsb pdb:6CUD|rcsb pdb:6D7L|rcsb pdb:6DJS psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops) - 2017/08/05 2017/08/10 rogid:VXcTrF/8sZA01XGUFZwvu75L7Kw9606 rogid:+cpkw8G+u8CX1vRaeVynSg3owOk9606 rigid:UynSZlXxWOCOXGPwLEaBc6T0Tdk false myc tag:n-n ha tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q61143 uniprotkb:Q96D31 intact:EBI-15563578|ensembl:ENSMUSP00000057965|uniprotkb:B9EIW2|uniprotkb:Q9Z2J1 intact:EBI-2291476|uniprotkb:Q3MHV3|uniprotkb:Q6DHX2|uniprotkb:Q96BP7|uniprotkb:Q96K71|ensembl:ENSP00000482568 psi-mi:trpc6_mouse(display_long)|uniprotkb:Trpc6(gene name)|psi-mi:Trpc6(display_short)|uniprotkb:Trp6(gene name synonym)|uniprotkb:Trrp6(gene name synonym)|uniprotkb:Calcium entry channel(gene name synonym)|uniprotkb:Transient receptor protein 6(gene name synonym) psi-mi:crcm1_human(display_long)|uniprotkb:ORAI1(gene name)|psi-mi:ORAI1(display_short)|uniprotkb:CRACM1(gene name synonym)|uniprotkb:TMEM142A(gene name synonym)|uniprotkb:Protein orai-1(gene name synonym)|uniprotkb:Transmembrane protein 142A(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Liao et al. (2007) pubmed:17360584|doi:10.1073/pnas.0611692104|imex:IM-22776 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15627352|imex:IM-22776-6|dip:DIP-196709E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000031997(gene)|ensembl:ENSMUST00000050433(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005216"(ion channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006828"(manganese ion transport)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007338"(single fertilization)|go:"GO:0007568"(aging)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0015279"(store-operated calcium channel activity)|go:"GO:0016020"(membrane)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030276"(clathrin binding)|go:"GO:0032414"(positive regulation of ion transmembrane transporter activity)|go:"GO:0034703"(cation channel complex)|go:"GO:0036057"(slit diaphragm)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042805"(actinin binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0050774"(negative regulation of dendrite morphogenesis)|go:"GO:0051117"(ATPase binding)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0070679"(inositol 1,4,5 trisphosphate binding)|go:"GO:0071456"(cellular response to hypoxia)|interpro:IPR002110(Ankyrin)|interpro:IPR002153(Transient receptor potential protein)|interpro:IPR005462(Transient receptor potential channel 6)|interpro:IPR005821(Ion transport)|interpro:IPR013555(Transient receptor potential II)|interpro:IPR020683|interpro:IPR036770|rcsb pdb:6CV9|reactome:R-MMU-114508|reactome:R-MMU-139853|reactome:R-MMU-3295583|refseq:NP_038866.2|refseq:XP_006509913.1|dip:DIP-60893N refseq:NP_116179.2|go:"GO:0070588"(calcium ion transmembrane transport)|interpro:IPR012446(Protein of unknown function DUF1650)|interpro:IPR038350|rcsb pdb:2MAK|rcsb pdb:4EHQ|reactome:R-HSA-139853|reactome:R-HSA-5578775|reactome:R-HSA-983695|ensembl:ENSG00000276045(gene)|ensembl:ENST00000617316(transcript)|go:"GO:0002115"(store-operated calcium entry)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0015279"(store-operated calcium channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045121"(membrane raft)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0061180"(mammary gland epithelium development)|go:"GO:0070509"(calcium ion import)|dip:DIP-46289N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/05 2017/08/10 rogid:hNvHCRgvRF7QFM77G5gWcce0Xc410090 rogid:VXcTrF/8sZA01XGUFZwvu75L7Kw9606 rigid:6fWuYwww7VnGYA73QQT1/2EkzAw false ha tag:n-n myc tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)