#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P0A6Y8 uniprotkb:A0A0G4PYZ0 intact:EBI-542092|uniprotkb:P04475|ensemblbacteria:AAC73125|ensemblbacteria:BAB96589 intact:EBI-25339717 psi-mi:dnak_ecoli(display_long)|uniprotkb:dnaK(gene name)|psi-mi:dnaK(display_short)|uniprotkb:groP(gene name synonym)|uniprotkb:grpF(gene name synonym)|uniprotkb:seg(gene name synonym)|uniprotkb:b0014(locus name)|uniprotkb:Heat shock protein 70(gene name synonym)|uniprotkb:Heat shock 70 kDa protein(gene name synonym)|uniprotkb:HSP70(gene name synonym)|uniprotkb:JW0013(locus name) psi-mi:a0a0g4pyz0_human(display_long)|uniprotkb:HLA-DRB1(gene name)|psi-mi:HLA-DRB1(display_short) psi-mi:"MI:0892"(solid phase assay) Haug et al. (2007) imex:IM-25683|pubmed:17357109 taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-13952081|imex:IM-25683-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_414555.1|ensemblbacteria:AAC73125(transcript)|ensemblbacteria:b0014(gene)|ensemblbacteria:BAB96589(gene)|ensemblbacteria:BAB96589(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006260"(DNA replication)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009408"(response to heat)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016989"(sigma factor antagonist activity)|go:"GO:0032984"(protein-containing complex disassembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0043531"(ADP binding)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR012725(Chaperone DnaK)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|rcsb pdb:1BPR|rcsb pdb:1DG4|rcsb pdb:1DKG|rcsb pdb:1DKX|rcsb pdb:1DKY|rcsb pdb:1DKZ|rcsb pdb:1Q5L|rcsb pdb:2BPR|rcsb pdb:2KHO|rcsb pdb:3DPO|rcsb pdb:3DPP|rcsb pdb:3DPQ|rcsb pdb:3QNJ|rcsb pdb:4B9Q|rcsb pdb:4E81|rcsb pdb:4EZN|rcsb pdb:4EZO|rcsb pdb:4EZP|rcsb pdb:4EZR|rcsb pdb:4EZS|rcsb pdb:4EZT|rcsb pdb:4EZU|rcsb pdb:4EZV|rcsb pdb:4EZW|rcsb pdb:4EZX|rcsb pdb:4EZY|rcsb pdb:4EZZ|rcsb pdb:4F00|rcsb pdb:4F01|rcsb pdb:4HY9|rcsb pdb:4HYB|rcsb pdb:4JN4|rcsb pdb:4JNE|rcsb pdb:4JNF|rcsb pdb:4JWC|rcsb pdb:4JWD|rcsb pdb:4JWE|rcsb pdb:4JWI|rcsb pdb:4R5G|rcsb pdb:4R5I|rcsb pdb:4R5J|rcsb pdb:4R5K|rcsb pdb:4R5L|rcsb pdb:5NRO|rcsb pdb:5OOW|rcsb pdb:7JMM|rcsb pdb:7JN8|rcsb pdb:7JN9|rcsb pdb:7JNE|rcsb pdb:7N6J|rcsb pdb:7N6K|rcsb pdb:7N6L|rcsb pdb:7N6M|rcsb pdb:4EZQ|refseq:WP_000516135.1|mint:P0A6Y8|dip:DIP-35751N interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR000353(MHC class II, beta chain, N-terminal) - - no-uniprot-update: figure legend:1A, 3|comment:HLA-DRB1*0801 allele|comment:The DRB1*0402 peptide did not inhibit binding, but all other peptides tested did.|antagonist:low pH|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:45.6x10^-6(molar) 2017/03/20 2020/01/09 rogid:jm8ErX3H3EOAYYuSDcddoE/NQx483333 rogid:2b6WKV5vcA/AaS5iDadYN7Pfcl49606 rigid:70m8ITc/UxKiPAoi1bwg+EQ3F6M false - sufficient binding region:94-106|biotin tag:?-? - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation) uniprotkb:P0A6Y8 uniprotkb:Q0R326 intact:EBI-542092|uniprotkb:P04475|ensemblbacteria:AAC73125|ensemblbacteria:BAB96589 intact:EBI-25339756 psi-mi:dnak_ecoli(display_long)|uniprotkb:dnaK(gene name)|psi-mi:dnaK(display_short)|uniprotkb:groP(gene name synonym)|uniprotkb:grpF(gene name synonym)|uniprotkb:seg(gene name synonym)|uniprotkb:b0014(locus name)|uniprotkb:Heat shock protein 70(gene name synonym)|uniprotkb:Heat shock 70 kDa protein(gene name synonym)|uniprotkb:HSP70(gene name synonym)|uniprotkb:JW0013(locus name) psi-mi:q0r326_human(display_long)|uniprotkb:HLA-DRB1(gene name)|psi-mi:HLA-DRB1(display_short)|uniprotkb:HLA-DRB5(gene name synonym)|uniprotkb:hCG_1998957(orf name) psi-mi:"MI:0892"(solid phase assay) Haug et al. (2007) imex:IM-25683|pubmed:17357109 taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13952179|imex:IM-25683-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0586"(inhibitor) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_414555.1|ensemblbacteria:AAC73125(transcript)|ensemblbacteria:b0014(gene)|ensemblbacteria:BAB96589(gene)|ensemblbacteria:BAB96589(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006260"(DNA replication)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009408"(response to heat)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016989"(sigma factor antagonist activity)|go:"GO:0032984"(protein-containing complex disassembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0043531"(ADP binding)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR012725(Chaperone DnaK)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|rcsb pdb:1BPR|rcsb pdb:1DG4|rcsb pdb:1DKG|rcsb pdb:1DKX|rcsb pdb:1DKY|rcsb pdb:1DKZ|rcsb pdb:1Q5L|rcsb pdb:2BPR|rcsb pdb:2KHO|rcsb pdb:3DPO|rcsb pdb:3DPP|rcsb pdb:3DPQ|rcsb pdb:3QNJ|rcsb pdb:4B9Q|rcsb pdb:4E81|rcsb pdb:4EZN|rcsb pdb:4EZO|rcsb pdb:4EZP|rcsb pdb:4EZR|rcsb pdb:4EZS|rcsb pdb:4EZT|rcsb pdb:4EZU|rcsb pdb:4EZV|rcsb pdb:4EZW|rcsb pdb:4EZX|rcsb pdb:4EZY|rcsb pdb:4EZZ|rcsb pdb:4F00|rcsb pdb:4F01|rcsb pdb:4HY9|rcsb pdb:4HYB|rcsb pdb:4JN4|rcsb pdb:4JNE|rcsb pdb:4JNF|rcsb pdb:4JWC|rcsb pdb:4JWD|rcsb pdb:4JWE|rcsb pdb:4JWI|rcsb pdb:4R5G|rcsb pdb:4R5I|rcsb pdb:4R5J|rcsb pdb:4R5K|rcsb pdb:4R5L|rcsb pdb:5NRO|rcsb pdb:5OOW|rcsb pdb:7JMM|rcsb pdb:7JN8|rcsb pdb:7JN9|rcsb pdb:7JNE|rcsb pdb:7N6J|rcsb pdb:7N6K|rcsb pdb:7N6L|rcsb pdb:7N6M|rcsb pdb:4EZQ|refseq:WP_000516135.1|mint:P0A6Y8|dip:DIP-35751N go:"GO:0016021"(integral component of membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002504"(antigen processing and presentation of peptide or polysaccharide antigen via MHC class II)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR000353(MHC class II, beta chain, N-terminal) - - no-uniprot-update: figure legend:1B-1|comment:"HLA-DRB1*0801 allele Inhibitor:HLA-DRB1*0901/DRB1*090102 allele (0901 sequence shown to contain errors and be identical to DRB1*09:01:02 (December 1996))."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/20 2020/01/09 rogid:jm8ErX3H3EOAYYuSDcddoE/NQx483333 rogid:Gq4S+WP70PV3KhQds27aWYtFaB09606 rigid:hLQP/nfaWD02igf7CT66ddwcu+I false - sufficient binding region:94-106 - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation) uniprotkb:P0A6Y8 uniprotkb:A0A0G4PYZ0 intact:EBI-542092|uniprotkb:P04475|ensemblbacteria:AAC73125|ensemblbacteria:BAB96589 intact:EBI-25339717 psi-mi:dnak_ecoli(display_long)|uniprotkb:dnaK(gene name)|psi-mi:dnaK(display_short)|uniprotkb:groP(gene name synonym)|uniprotkb:grpF(gene name synonym)|uniprotkb:seg(gene name synonym)|uniprotkb:b0014(locus name)|uniprotkb:Heat shock protein 70(gene name synonym)|uniprotkb:Heat shock 70 kDa protein(gene name synonym)|uniprotkb:HSP70(gene name synonym)|uniprotkb:JW0013(locus name) psi-mi:a0a0g4pyz0_human(display_long)|uniprotkb:HLA-DRB1(gene name)|psi-mi:HLA-DRB1(display_short) psi-mi:"MI:0892"(solid phase assay) Haug et al. (2007) imex:IM-25683|pubmed:17357109 taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13952179|imex:IM-25683-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_414555.1|ensemblbacteria:AAC73125(transcript)|ensemblbacteria:b0014(gene)|ensemblbacteria:BAB96589(gene)|ensemblbacteria:BAB96589(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006260"(DNA replication)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009408"(response to heat)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016989"(sigma factor antagonist activity)|go:"GO:0032984"(protein-containing complex disassembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0043531"(ADP binding)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR012725(Chaperone DnaK)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|rcsb pdb:1BPR|rcsb pdb:1DG4|rcsb pdb:1DKG|rcsb pdb:1DKX|rcsb pdb:1DKY|rcsb pdb:1DKZ|rcsb pdb:1Q5L|rcsb pdb:2BPR|rcsb pdb:2KHO|rcsb pdb:3DPO|rcsb pdb:3DPP|rcsb pdb:3DPQ|rcsb pdb:3QNJ|rcsb pdb:4B9Q|rcsb pdb:4E81|rcsb pdb:4EZN|rcsb pdb:4EZO|rcsb pdb:4EZP|rcsb pdb:4EZR|rcsb pdb:4EZS|rcsb pdb:4EZT|rcsb pdb:4EZU|rcsb pdb:4EZV|rcsb pdb:4EZW|rcsb pdb:4EZX|rcsb pdb:4EZY|rcsb pdb:4EZZ|rcsb pdb:4F00|rcsb pdb:4F01|rcsb pdb:4HY9|rcsb pdb:4HYB|rcsb pdb:4JN4|rcsb pdb:4JNE|rcsb pdb:4JNF|rcsb pdb:4JWC|rcsb pdb:4JWD|rcsb pdb:4JWE|rcsb pdb:4JWI|rcsb pdb:4R5G|rcsb pdb:4R5I|rcsb pdb:4R5J|rcsb pdb:4R5K|rcsb pdb:4R5L|rcsb pdb:5NRO|rcsb pdb:5OOW|rcsb pdb:7JMM|rcsb pdb:7JN8|rcsb pdb:7JN9|rcsb pdb:7JNE|rcsb pdb:7N6J|rcsb pdb:7N6K|rcsb pdb:7N6L|rcsb pdb:7N6M|rcsb pdb:4EZQ|refseq:WP_000516135.1|mint:P0A6Y8|dip:DIP-35751N interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR000353(MHC class II, beta chain, N-terminal) - - no-uniprot-update: figure legend:1B-1|comment:"HLA-DRB1*0801 allele Inhibitor:HLA-DRB1*0901/DRB1*090102 allele (0901 sequence shown to contain errors and be identical to DRB1*09:01:02 (December 1996))."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/20 2020/01/09 rogid:jm8ErX3H3EOAYYuSDcddoE/NQx483333 rogid:2b6WKV5vcA/AaS5iDadYN7Pfcl49606 rigid:hLQP/nfaWD02igf7CT66ddwcu+I false - sufficient binding region:94-106|biotin tag:?-? - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation) uniprotkb:P0A6Y8 uniprotkb:A0A1V1IGJ9 intact:EBI-542092|uniprotkb:P04475|ensemblbacteria:AAC73125|ensemblbacteria:BAB96589 intact:EBI-25339774 psi-mi:dnak_ecoli(display_long)|uniprotkb:dnaK(gene name)|psi-mi:dnaK(display_short)|uniprotkb:groP(gene name synonym)|uniprotkb:grpF(gene name synonym)|uniprotkb:seg(gene name synonym)|uniprotkb:b0014(locus name)|uniprotkb:Heat shock protein 70(gene name synonym)|uniprotkb:Heat shock 70 kDa protein(gene name synonym)|uniprotkb:HSP70(gene name synonym)|uniprotkb:JW0013(locus name) psi-mi:a0a1v1igj9_human(display_long)|uniprotkb:HLA-DRB1(gene name)|psi-mi:HLA-DRB1(display_short) psi-mi:"MI:0892"(solid phase assay) Haug et al. (2007) imex:IM-25683|pubmed:17357109 taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13952269|imex:IM-25683-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0586"(inhibitor) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_414555.1|ensemblbacteria:AAC73125(transcript)|ensemblbacteria:b0014(gene)|ensemblbacteria:BAB96589(gene)|ensemblbacteria:BAB96589(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006260"(DNA replication)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009408"(response to heat)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016989"(sigma factor antagonist activity)|go:"GO:0032984"(protein-containing complex disassembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0043531"(ADP binding)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR012725(Chaperone DnaK)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|rcsb pdb:1BPR|rcsb pdb:1DG4|rcsb pdb:1DKG|rcsb pdb:1DKX|rcsb pdb:1DKY|rcsb pdb:1DKZ|rcsb pdb:1Q5L|rcsb pdb:2BPR|rcsb pdb:2KHO|rcsb pdb:3DPO|rcsb pdb:3DPP|rcsb pdb:3DPQ|rcsb pdb:3QNJ|rcsb pdb:4B9Q|rcsb pdb:4E81|rcsb pdb:4EZN|rcsb pdb:4EZO|rcsb pdb:4EZP|rcsb pdb:4EZR|rcsb pdb:4EZS|rcsb pdb:4EZT|rcsb pdb:4EZU|rcsb pdb:4EZV|rcsb pdb:4EZW|rcsb pdb:4EZX|rcsb pdb:4EZY|rcsb pdb:4EZZ|rcsb pdb:4F00|rcsb pdb:4F01|rcsb pdb:4HY9|rcsb pdb:4HYB|rcsb pdb:4JN4|rcsb pdb:4JNE|rcsb pdb:4JNF|rcsb pdb:4JWC|rcsb pdb:4JWD|rcsb pdb:4JWE|rcsb pdb:4JWI|rcsb pdb:4R5G|rcsb pdb:4R5I|rcsb pdb:4R5J|rcsb pdb:4R5K|rcsb pdb:4R5L|rcsb pdb:5NRO|rcsb pdb:5OOW|rcsb pdb:7JMM|rcsb pdb:7JN8|rcsb pdb:7JN9|rcsb pdb:7JNE|rcsb pdb:7N6J|rcsb pdb:7N6K|rcsb pdb:7N6L|rcsb pdb:7N6M|rcsb pdb:4EZQ|refseq:WP_000516135.1|mint:P0A6Y8|dip:DIP-35751N interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR000353(MHC class II, beta chain, N-terminal) - - no-uniprot-update: figure legend:1B-2|comment:"HLA-DRB1*0801 allele Inhibitor: HLA-DRB1*0403"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/20 2020/01/09 rogid:jm8ErX3H3EOAYYuSDcddoE/NQx483333 rogid:t0oiEebDmTMAhQ97YLbgIkwvFek9606 rigid:n8xaDXBFMDvl5rFgPgPLTz0dVjM false - sufficient binding region:94-106|mutation:103-103,100-100 - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation) uniprotkb:P0A6Y8 uniprotkb:A0A0G4PYZ0 intact:EBI-542092|uniprotkb:P04475|ensemblbacteria:AAC73125|ensemblbacteria:BAB96589 intact:EBI-25339717 psi-mi:dnak_ecoli(display_long)|uniprotkb:dnaK(gene name)|psi-mi:dnaK(display_short)|uniprotkb:groP(gene name synonym)|uniprotkb:grpF(gene name synonym)|uniprotkb:seg(gene name synonym)|uniprotkb:b0014(locus name)|uniprotkb:Heat shock protein 70(gene name synonym)|uniprotkb:Heat shock 70 kDa protein(gene name synonym)|uniprotkb:HSP70(gene name synonym)|uniprotkb:JW0013(locus name) psi-mi:a0a0g4pyz0_human(display_long)|uniprotkb:HLA-DRB1(gene name)|psi-mi:HLA-DRB1(display_short) psi-mi:"MI:0892"(solid phase assay) Haug et al. (2007) imex:IM-25683|pubmed:17357109 taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13952269|imex:IM-25683-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_414555.1|ensemblbacteria:AAC73125(transcript)|ensemblbacteria:b0014(gene)|ensemblbacteria:BAB96589(gene)|ensemblbacteria:BAB96589(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006260"(DNA replication)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009408"(response to heat)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016989"(sigma factor antagonist activity)|go:"GO:0032984"(protein-containing complex disassembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0043531"(ADP binding)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR012725(Chaperone DnaK)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|rcsb pdb:1BPR|rcsb pdb:1DG4|rcsb pdb:1DKG|rcsb pdb:1DKX|rcsb pdb:1DKY|rcsb pdb:1DKZ|rcsb pdb:1Q5L|rcsb pdb:2BPR|rcsb pdb:2KHO|rcsb pdb:3DPO|rcsb pdb:3DPP|rcsb pdb:3DPQ|rcsb pdb:3QNJ|rcsb pdb:4B9Q|rcsb pdb:4E81|rcsb pdb:4EZN|rcsb pdb:4EZO|rcsb pdb:4EZP|rcsb pdb:4EZR|rcsb pdb:4EZS|rcsb pdb:4EZT|rcsb pdb:4EZU|rcsb pdb:4EZV|rcsb pdb:4EZW|rcsb pdb:4EZX|rcsb pdb:4EZY|rcsb pdb:4EZZ|rcsb pdb:4F00|rcsb pdb:4F01|rcsb pdb:4HY9|rcsb pdb:4HYB|rcsb pdb:4JN4|rcsb pdb:4JNE|rcsb pdb:4JNF|rcsb pdb:4JWC|rcsb pdb:4JWD|rcsb pdb:4JWE|rcsb pdb:4JWI|rcsb pdb:4R5G|rcsb pdb:4R5I|rcsb pdb:4R5J|rcsb pdb:4R5K|rcsb pdb:4R5L|rcsb pdb:5NRO|rcsb pdb:5OOW|rcsb pdb:7JMM|rcsb pdb:7JN8|rcsb pdb:7JN9|rcsb pdb:7JNE|rcsb pdb:7N6J|rcsb pdb:7N6K|rcsb pdb:7N6L|rcsb pdb:7N6M|rcsb pdb:4EZQ|refseq:WP_000516135.1|mint:P0A6Y8|dip:DIP-35751N interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR000353(MHC class II, beta chain, N-terminal) - - no-uniprot-update: figure legend:1B-2|comment:"HLA-DRB1*0801 allele Inhibitor: HLA-DRB1*0403"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/20 2020/01/09 rogid:jm8ErX3H3EOAYYuSDcddoE/NQx483333 rogid:2b6WKV5vcA/AaS5iDadYN7Pfcl49606 rigid:n8xaDXBFMDvl5rFgPgPLTz0dVjM false - sufficient binding region:94-106|biotin tag:?-? - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation) uniprotkb:P0A6Y8 uniprotkb:A0A1V1IGJ9 intact:EBI-542092|uniprotkb:P04475|ensemblbacteria:AAC73125|ensemblbacteria:BAB96589 intact:EBI-25339774 psi-mi:dnak_ecoli(display_long)|uniprotkb:dnaK(gene name)|psi-mi:dnaK(display_short)|uniprotkb:groP(gene name synonym)|uniprotkb:grpF(gene name synonym)|uniprotkb:seg(gene name synonym)|uniprotkb:b0014(locus name)|uniprotkb:Heat shock protein 70(gene name synonym)|uniprotkb:Heat shock 70 kDa protein(gene name synonym)|uniprotkb:HSP70(gene name synonym)|uniprotkb:JW0013(locus name) psi-mi:a0a1v1igj9_human(display_long)|uniprotkb:HLA-DRB1(gene name)|psi-mi:HLA-DRB1(display_short) psi-mi:"MI:0892"(solid phase assay) Haug et al. (2007) imex:IM-25683|pubmed:17357109 taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13952290|imex:IM-25683-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0586"(inhibitor) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_414555.1|ensemblbacteria:AAC73125(transcript)|ensemblbacteria:b0014(gene)|ensemblbacteria:BAB96589(gene)|ensemblbacteria:BAB96589(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006260"(DNA replication)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009408"(response to heat)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016989"(sigma factor antagonist activity)|go:"GO:0032984"(protein-containing complex disassembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0043531"(ADP binding)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR012725(Chaperone DnaK)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|rcsb pdb:1BPR|rcsb pdb:1DG4|rcsb pdb:1DKG|rcsb pdb:1DKX|rcsb pdb:1DKY|rcsb pdb:1DKZ|rcsb pdb:1Q5L|rcsb pdb:2BPR|rcsb pdb:2KHO|rcsb pdb:3DPO|rcsb pdb:3DPP|rcsb pdb:3DPQ|rcsb pdb:3QNJ|rcsb pdb:4B9Q|rcsb pdb:4E81|rcsb pdb:4EZN|rcsb pdb:4EZO|rcsb pdb:4EZP|rcsb pdb:4EZR|rcsb pdb:4EZS|rcsb pdb:4EZT|rcsb pdb:4EZU|rcsb pdb:4EZV|rcsb pdb:4EZW|rcsb pdb:4EZX|rcsb pdb:4EZY|rcsb pdb:4EZZ|rcsb pdb:4F00|rcsb pdb:4F01|rcsb pdb:4HY9|rcsb pdb:4HYB|rcsb pdb:4JN4|rcsb pdb:4JNE|rcsb pdb:4JNF|rcsb pdb:4JWC|rcsb pdb:4JWD|rcsb pdb:4JWE|rcsb pdb:4JWI|rcsb pdb:4R5G|rcsb pdb:4R5I|rcsb pdb:4R5J|rcsb pdb:4R5K|rcsb pdb:4R5L|rcsb pdb:5NRO|rcsb pdb:5OOW|rcsb pdb:7JMM|rcsb pdb:7JN8|rcsb pdb:7JN9|rcsb pdb:7JNE|rcsb pdb:7N6J|rcsb pdb:7N6K|rcsb pdb:7N6L|rcsb pdb:7N6M|rcsb pdb:4EZQ|refseq:WP_000516135.1|mint:P0A6Y8|dip:DIP-35751N interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR000353(MHC class II, beta chain, N-terminal) - - no-uniprot-update: figure legend:1B-3|comment:"HLA-DRB1*0801 allele Inhibitor: HLA-DRB1*0401"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/20 2020/01/09 rogid:jm8ErX3H3EOAYYuSDcddoE/NQx483333 rogid:t0oiEebDmTMAhQ97YLbgIkwvFek9606 rigid:n8xaDXBFMDvl5rFgPgPLTz0dVjM false - sufficient binding region:94-106 - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation) uniprotkb:P0A6Y8 uniprotkb:A0A0G4PYZ0 intact:EBI-542092|uniprotkb:P04475|ensemblbacteria:AAC73125|ensemblbacteria:BAB96589 intact:EBI-25339717 psi-mi:dnak_ecoli(display_long)|uniprotkb:dnaK(gene name)|psi-mi:dnaK(display_short)|uniprotkb:groP(gene name synonym)|uniprotkb:grpF(gene name synonym)|uniprotkb:seg(gene name synonym)|uniprotkb:b0014(locus name)|uniprotkb:Heat shock protein 70(gene name synonym)|uniprotkb:Heat shock 70 kDa protein(gene name synonym)|uniprotkb:HSP70(gene name synonym)|uniprotkb:JW0013(locus name) psi-mi:a0a0g4pyz0_human(display_long)|uniprotkb:HLA-DRB1(gene name)|psi-mi:HLA-DRB1(display_short) psi-mi:"MI:0892"(solid phase assay) Haug et al. (2007) imex:IM-25683|pubmed:17357109 taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13952290|imex:IM-25683-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_414555.1|ensemblbacteria:AAC73125(transcript)|ensemblbacteria:b0014(gene)|ensemblbacteria:BAB96589(gene)|ensemblbacteria:BAB96589(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006260"(DNA replication)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009408"(response to heat)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016989"(sigma factor antagonist activity)|go:"GO:0032984"(protein-containing complex disassembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0043531"(ADP binding)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR012725(Chaperone DnaK)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|rcsb pdb:1BPR|rcsb pdb:1DG4|rcsb pdb:1DKG|rcsb pdb:1DKX|rcsb pdb:1DKY|rcsb pdb:1DKZ|rcsb pdb:1Q5L|rcsb pdb:2BPR|rcsb pdb:2KHO|rcsb pdb:3DPO|rcsb pdb:3DPP|rcsb pdb:3DPQ|rcsb pdb:3QNJ|rcsb pdb:4B9Q|rcsb pdb:4E81|rcsb pdb:4EZN|rcsb pdb:4EZO|rcsb pdb:4EZP|rcsb pdb:4EZR|rcsb pdb:4EZS|rcsb pdb:4EZT|rcsb pdb:4EZU|rcsb pdb:4EZV|rcsb pdb:4EZW|rcsb pdb:4EZX|rcsb pdb:4EZY|rcsb pdb:4EZZ|rcsb pdb:4F00|rcsb pdb:4F01|rcsb pdb:4HY9|rcsb pdb:4HYB|rcsb pdb:4JN4|rcsb pdb:4JNE|rcsb pdb:4JNF|rcsb pdb:4JWC|rcsb pdb:4JWD|rcsb pdb:4JWE|rcsb pdb:4JWI|rcsb pdb:4R5G|rcsb pdb:4R5I|rcsb pdb:4R5J|rcsb pdb:4R5K|rcsb pdb:4R5L|rcsb pdb:5NRO|rcsb pdb:5OOW|rcsb pdb:7JMM|rcsb pdb:7JN8|rcsb pdb:7JN9|rcsb pdb:7JNE|rcsb pdb:7N6J|rcsb pdb:7N6K|rcsb pdb:7N6L|rcsb pdb:7N6M|rcsb pdb:4EZQ|refseq:WP_000516135.1|mint:P0A6Y8|dip:DIP-35751N interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR000353(MHC class II, beta chain, N-terminal) - - no-uniprot-update: figure legend:1B-3|comment:"HLA-DRB1*0801 allele Inhibitor: HLA-DRB1*0401"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/20 2020/01/09 rogid:jm8ErX3H3EOAYYuSDcddoE/NQx483333 rogid:2b6WKV5vcA/AaS5iDadYN7Pfcl49606 rigid:n8xaDXBFMDvl5rFgPgPLTz0dVjM false - sufficient binding region:94-106|biotin tag:?-? - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation) uniprotkb:P0A6Y8 uniprotkb:D7RIG0 intact:EBI-542092|uniprotkb:P04475|ensemblbacteria:AAC73125|ensemblbacteria:BAB96589 intact:EBI-25339681 psi-mi:dnak_ecoli(display_long)|uniprotkb:dnaK(gene name)|psi-mi:dnaK(display_short)|uniprotkb:groP(gene name synonym)|uniprotkb:grpF(gene name synonym)|uniprotkb:seg(gene name synonym)|uniprotkb:b0014(locus name)|uniprotkb:Heat shock protein 70(gene name synonym)|uniprotkb:Heat shock 70 kDa protein(gene name synonym)|uniprotkb:HSP70(gene name synonym)|uniprotkb:JW0013(locus name) psi-mi:d7rig0_human(display_long)|uniprotkb:HLA-DRB1(gene name)|psi-mi:HLA-DRB1(display_short) psi-mi:"MI:0892"(solid phase assay) Haug et al. (2007) imex:IM-25683|pubmed:17357109 taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13952327|imex:IM-25683-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0586"(inhibitor) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_414555.1|ensemblbacteria:AAC73125(transcript)|ensemblbacteria:b0014(gene)|ensemblbacteria:BAB96589(gene)|ensemblbacteria:BAB96589(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006260"(DNA replication)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009408"(response to heat)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016989"(sigma factor antagonist activity)|go:"GO:0032984"(protein-containing complex disassembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0043531"(ADP binding)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR012725(Chaperone DnaK)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|rcsb pdb:1BPR|rcsb pdb:1DG4|rcsb pdb:1DKG|rcsb pdb:1DKX|rcsb pdb:1DKY|rcsb pdb:1DKZ|rcsb pdb:1Q5L|rcsb pdb:2BPR|rcsb pdb:2KHO|rcsb pdb:3DPO|rcsb pdb:3DPP|rcsb pdb:3DPQ|rcsb pdb:3QNJ|rcsb pdb:4B9Q|rcsb pdb:4E81|rcsb pdb:4EZN|rcsb pdb:4EZO|rcsb pdb:4EZP|rcsb pdb:4EZR|rcsb pdb:4EZS|rcsb pdb:4EZT|rcsb pdb:4EZU|rcsb pdb:4EZV|rcsb pdb:4EZW|rcsb pdb:4EZX|rcsb pdb:4EZY|rcsb pdb:4EZZ|rcsb pdb:4F00|rcsb pdb:4F01|rcsb pdb:4HY9|rcsb pdb:4HYB|rcsb pdb:4JN4|rcsb pdb:4JNE|rcsb pdb:4JNF|rcsb pdb:4JWC|rcsb pdb:4JWD|rcsb pdb:4JWE|rcsb pdb:4JWI|rcsb pdb:4R5G|rcsb pdb:4R5I|rcsb pdb:4R5J|rcsb pdb:4R5K|rcsb pdb:4R5L|rcsb pdb:5NRO|rcsb pdb:5OOW|rcsb pdb:7JMM|rcsb pdb:7JN8|rcsb pdb:7JN9|rcsb pdb:7JNE|rcsb pdb:7N6J|rcsb pdb:7N6K|rcsb pdb:7N6L|rcsb pdb:7N6M|rcsb pdb:4EZQ|refseq:WP_000516135.1|mint:P0A6Y8|dip:DIP-35751N go:"GO:0016021"(integral component of membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002504"(antigen processing and presentation of peptide or polysaccharide antigen via MHC class II)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR000353(MHC class II, beta chain, N-terminal) - - no-uniprot-update: figure legend:1B-4|comment:"HLA-DRB1*0801 allele Inhibitor: HLA-DRB1*0101"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/20 2020/01/09 rogid:jm8ErX3H3EOAYYuSDcddoE/NQx483333 rogid:vCNdHdbtlKcoI2NPKfDiiFm88sQ9606 rigid:bDUG78mQ4usuMaASQMjuQGyRUMk false - sufficient binding region:94-106 - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation) uniprotkb:P0A6Y8 uniprotkb:A0A0G4PYZ0 intact:EBI-542092|uniprotkb:P04475|ensemblbacteria:AAC73125|ensemblbacteria:BAB96589 intact:EBI-25339717 psi-mi:dnak_ecoli(display_long)|uniprotkb:dnaK(gene name)|psi-mi:dnaK(display_short)|uniprotkb:groP(gene name synonym)|uniprotkb:grpF(gene name synonym)|uniprotkb:seg(gene name synonym)|uniprotkb:b0014(locus name)|uniprotkb:Heat shock protein 70(gene name synonym)|uniprotkb:Heat shock 70 kDa protein(gene name synonym)|uniprotkb:HSP70(gene name synonym)|uniprotkb:JW0013(locus name) psi-mi:a0a0g4pyz0_human(display_long)|uniprotkb:HLA-DRB1(gene name)|psi-mi:HLA-DRB1(display_short) psi-mi:"MI:0892"(solid phase assay) Haug et al. (2007) imex:IM-25683|pubmed:17357109 taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13952327|imex:IM-25683-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_414555.1|ensemblbacteria:AAC73125(transcript)|ensemblbacteria:b0014(gene)|ensemblbacteria:BAB96589(gene)|ensemblbacteria:BAB96589(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006260"(DNA replication)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009408"(response to heat)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016989"(sigma factor antagonist activity)|go:"GO:0032984"(protein-containing complex disassembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0043531"(ADP binding)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR012725(Chaperone DnaK)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|rcsb pdb:1BPR|rcsb pdb:1DG4|rcsb pdb:1DKG|rcsb pdb:1DKX|rcsb pdb:1DKY|rcsb pdb:1DKZ|rcsb pdb:1Q5L|rcsb pdb:2BPR|rcsb pdb:2KHO|rcsb pdb:3DPO|rcsb pdb:3DPP|rcsb pdb:3DPQ|rcsb pdb:3QNJ|rcsb pdb:4B9Q|rcsb pdb:4E81|rcsb pdb:4EZN|rcsb pdb:4EZO|rcsb pdb:4EZP|rcsb pdb:4EZR|rcsb pdb:4EZS|rcsb pdb:4EZT|rcsb pdb:4EZU|rcsb pdb:4EZV|rcsb pdb:4EZW|rcsb pdb:4EZX|rcsb pdb:4EZY|rcsb pdb:4EZZ|rcsb pdb:4F00|rcsb pdb:4F01|rcsb pdb:4HY9|rcsb pdb:4HYB|rcsb pdb:4JN4|rcsb pdb:4JNE|rcsb pdb:4JNF|rcsb pdb:4JWC|rcsb pdb:4JWD|rcsb pdb:4JWE|rcsb pdb:4JWI|rcsb pdb:4R5G|rcsb pdb:4R5I|rcsb pdb:4R5J|rcsb pdb:4R5K|rcsb pdb:4R5L|rcsb pdb:5NRO|rcsb pdb:5OOW|rcsb pdb:7JMM|rcsb pdb:7JN8|rcsb pdb:7JN9|rcsb pdb:7JNE|rcsb pdb:7N6J|rcsb pdb:7N6K|rcsb pdb:7N6L|rcsb pdb:7N6M|rcsb pdb:4EZQ|refseq:WP_000516135.1|mint:P0A6Y8|dip:DIP-35751N interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR000353(MHC class II, beta chain, N-terminal) - - no-uniprot-update: figure legend:1B-4|comment:"HLA-DRB1*0801 allele Inhibitor: HLA-DRB1*0101"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/20 2020/01/09 rogid:jm8ErX3H3EOAYYuSDcddoE/NQx483333 rogid:2b6WKV5vcA/AaS5iDadYN7Pfcl49606 rigid:bDUG78mQ4usuMaASQMjuQGyRUMk false - sufficient binding region:94-106|biotin tag:?-? - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation) uniprotkb:P0A6Y8 uniprotkb:A0A0G4PYZ0 intact:EBI-542092|uniprotkb:P04475|ensemblbacteria:AAC73125|ensemblbacteria:BAB96589 intact:EBI-25339717 psi-mi:dnak_ecoli(display_long)|uniprotkb:dnaK(gene name)|psi-mi:dnaK(display_short)|uniprotkb:groP(gene name synonym)|uniprotkb:grpF(gene name synonym)|uniprotkb:seg(gene name synonym)|uniprotkb:b0014(locus name)|uniprotkb:Heat shock protein 70(gene name synonym)|uniprotkb:Heat shock 70 kDa protein(gene name synonym)|uniprotkb:HSP70(gene name synonym)|uniprotkb:JW0013(locus name) psi-mi:a0a0g4pyz0_human(display_long)|uniprotkb:HLA-DRB1(gene name)|psi-mi:HLA-DRB1(display_short) psi-mi:"MI:0892"(solid phase assay) Haug et al. (2007) imex:IM-25683|pubmed:17357109 taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13952353|imex:IM-25683-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0586"(inhibitor) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_414555.1|ensemblbacteria:AAC73125(transcript)|ensemblbacteria:b0014(gene)|ensemblbacteria:BAB96589(gene)|ensemblbacteria:BAB96589(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006260"(DNA replication)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009408"(response to heat)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016989"(sigma factor antagonist activity)|go:"GO:0032984"(protein-containing complex disassembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0043531"(ADP binding)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR012725(Chaperone DnaK)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|rcsb pdb:1BPR|rcsb pdb:1DG4|rcsb pdb:1DKG|rcsb pdb:1DKX|rcsb pdb:1DKY|rcsb pdb:1DKZ|rcsb pdb:1Q5L|rcsb pdb:2BPR|rcsb pdb:2KHO|rcsb pdb:3DPO|rcsb pdb:3DPP|rcsb pdb:3DPQ|rcsb pdb:3QNJ|rcsb pdb:4B9Q|rcsb pdb:4E81|rcsb pdb:4EZN|rcsb pdb:4EZO|rcsb pdb:4EZP|rcsb pdb:4EZR|rcsb pdb:4EZS|rcsb pdb:4EZT|rcsb pdb:4EZU|rcsb pdb:4EZV|rcsb pdb:4EZW|rcsb pdb:4EZX|rcsb pdb:4EZY|rcsb pdb:4EZZ|rcsb pdb:4F00|rcsb pdb:4F01|rcsb pdb:4HY9|rcsb pdb:4HYB|rcsb pdb:4JN4|rcsb pdb:4JNE|rcsb pdb:4JNF|rcsb pdb:4JWC|rcsb pdb:4JWD|rcsb pdb:4JWE|rcsb pdb:4JWI|rcsb pdb:4R5G|rcsb pdb:4R5I|rcsb pdb:4R5J|rcsb pdb:4R5K|rcsb pdb:4R5L|rcsb pdb:5NRO|rcsb pdb:5OOW|rcsb pdb:7JMM|rcsb pdb:7JN8|rcsb pdb:7JN9|rcsb pdb:7JNE|rcsb pdb:7N6J|rcsb pdb:7N6K|rcsb pdb:7N6L|rcsb pdb:7N6M|rcsb pdb:4EZQ|refseq:WP_000516135.1|mint:P0A6Y8|dip:DIP-35751N interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR000353(MHC class II, beta chain, N-terminal) - - no-uniprot-update: figure legend:1B-5|comment:"HLA-DRB1*0801 allele Inhibitor: HLA-DRB1*0801"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/20 2020/01/09 rogid:jm8ErX3H3EOAYYuSDcddoE/NQx483333 rogid:2b6WKV5vcA/AaS5iDadYN7Pfcl49606 rigid:70m8ITc/UxKiPAoi1bwg+EQ3F6M false - sufficient binding region:94-106 - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation) uniprotkb:P0A6Y8 uniprotkb:A0A0G4PYZ0 intact:EBI-542092|uniprotkb:P04475|ensemblbacteria:AAC73125|ensemblbacteria:BAB96589 intact:EBI-25339717 psi-mi:dnak_ecoli(display_long)|uniprotkb:dnaK(gene name)|psi-mi:dnaK(display_short)|uniprotkb:groP(gene name synonym)|uniprotkb:grpF(gene name synonym)|uniprotkb:seg(gene name synonym)|uniprotkb:b0014(locus name)|uniprotkb:Heat shock protein 70(gene name synonym)|uniprotkb:Heat shock 70 kDa protein(gene name synonym)|uniprotkb:HSP70(gene name synonym)|uniprotkb:JW0013(locus name) psi-mi:a0a0g4pyz0_human(display_long)|uniprotkb:HLA-DRB1(gene name)|psi-mi:HLA-DRB1(display_short) psi-mi:"MI:0892"(solid phase assay) Haug et al. (2007) imex:IM-25683|pubmed:17357109 taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13952353|imex:IM-25683-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_414555.1|ensemblbacteria:AAC73125(transcript)|ensemblbacteria:b0014(gene)|ensemblbacteria:BAB96589(gene)|ensemblbacteria:BAB96589(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006260"(DNA replication)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009408"(response to heat)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016989"(sigma factor antagonist activity)|go:"GO:0032984"(protein-containing complex disassembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0043531"(ADP binding)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR012725(Chaperone DnaK)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|rcsb pdb:1BPR|rcsb pdb:1DG4|rcsb pdb:1DKG|rcsb pdb:1DKX|rcsb pdb:1DKY|rcsb pdb:1DKZ|rcsb pdb:1Q5L|rcsb pdb:2BPR|rcsb pdb:2KHO|rcsb pdb:3DPO|rcsb pdb:3DPP|rcsb pdb:3DPQ|rcsb pdb:3QNJ|rcsb pdb:4B9Q|rcsb pdb:4E81|rcsb pdb:4EZN|rcsb pdb:4EZO|rcsb pdb:4EZP|rcsb pdb:4EZR|rcsb pdb:4EZS|rcsb pdb:4EZT|rcsb pdb:4EZU|rcsb pdb:4EZV|rcsb pdb:4EZW|rcsb pdb:4EZX|rcsb pdb:4EZY|rcsb pdb:4EZZ|rcsb pdb:4F00|rcsb pdb:4F01|rcsb pdb:4HY9|rcsb pdb:4HYB|rcsb pdb:4JN4|rcsb pdb:4JNE|rcsb pdb:4JNF|rcsb pdb:4JWC|rcsb pdb:4JWD|rcsb pdb:4JWE|rcsb pdb:4JWI|rcsb pdb:4R5G|rcsb pdb:4R5I|rcsb pdb:4R5J|rcsb pdb:4R5K|rcsb pdb:4R5L|rcsb pdb:5NRO|rcsb pdb:5OOW|rcsb pdb:7JMM|rcsb pdb:7JN8|rcsb pdb:7JN9|rcsb pdb:7JNE|rcsb pdb:7N6J|rcsb pdb:7N6K|rcsb pdb:7N6L|rcsb pdb:7N6M|rcsb pdb:4EZQ|refseq:WP_000516135.1|mint:P0A6Y8|dip:DIP-35751N interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR000353(MHC class II, beta chain, N-terminal) - - no-uniprot-update: figure legend:1B-5|comment:"HLA-DRB1*0801 allele Inhibitor: HLA-DRB1*0801"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/20 2020/01/09 rogid:jm8ErX3H3EOAYYuSDcddoE/NQx483333 rogid:2b6WKV5vcA/AaS5iDadYN7Pfcl49606 rigid:70m8ITc/UxKiPAoi1bwg+EQ3F6M false - sufficient binding region:94-106|biotin tag:?-? - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation) uniprotkb:P0A6Y8 uniprotkb:P04233 intact:EBI-542092|uniprotkb:P04475|ensemblbacteria:AAC73125|ensemblbacteria:BAB96589 intact:EBI-2622890|uniprotkb:D3DQG3|uniprotkb:D3DQG4|uniprotkb:A8K7R1|uniprotkb:B4DNE8|uniprotkb:Q29832|uniprotkb:Q14597|uniprotkb:Q8SNA0|uniprotkb:Q8WLP6|uniprotkb:Q5U0J8|ensembl:ENSP00000009530 psi-mi:dnak_ecoli(display_long)|uniprotkb:dnaK(gene name)|psi-mi:dnaK(display_short)|uniprotkb:groP(gene name synonym)|uniprotkb:grpF(gene name synonym)|uniprotkb:seg(gene name synonym)|uniprotkb:b0014(locus name)|uniprotkb:Heat shock protein 70(gene name synonym)|uniprotkb:Heat shock 70 kDa protein(gene name synonym)|uniprotkb:HSP70(gene name synonym)|uniprotkb:JW0013(locus name) psi-mi:hg2a_human(display_long)|uniprotkb:DHLAG(gene name synonym)|uniprotkb:HLA-DR antigens-associated invariant chain(gene name synonym)|uniprotkb:Ia antigen-associated invariant chain(gene name synonym)|uniprotkb:CD74(gene name)|psi-mi:CD74(display_short) psi-mi:"MI:0892"(solid phase assay) Haug et al. (2007) imex:IM-25683|pubmed:17357109 taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-13952558|imex:IM-25683-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_414555.1|ensemblbacteria:AAC73125(transcript)|ensemblbacteria:b0014(gene)|ensemblbacteria:BAB96589(gene)|ensemblbacteria:BAB96589(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006260"(DNA replication)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009408"(response to heat)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016989"(sigma factor antagonist activity)|go:"GO:0032984"(protein-containing complex disassembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0043531"(ADP binding)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR012725(Chaperone DnaK)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|rcsb pdb:1BPR|rcsb pdb:1DG4|rcsb pdb:1DKG|rcsb pdb:1DKX|rcsb pdb:1DKY|rcsb pdb:1DKZ|rcsb pdb:1Q5L|rcsb pdb:2BPR|rcsb pdb:2KHO|rcsb pdb:3DPO|rcsb pdb:3DPP|rcsb pdb:3DPQ|rcsb pdb:3QNJ|rcsb pdb:4B9Q|rcsb pdb:4E81|rcsb pdb:4EZN|rcsb pdb:4EZO|rcsb pdb:4EZP|rcsb pdb:4EZR|rcsb pdb:4EZS|rcsb pdb:4EZT|rcsb pdb:4EZU|rcsb pdb:4EZV|rcsb pdb:4EZW|rcsb pdb:4EZX|rcsb pdb:4EZY|rcsb pdb:4EZZ|rcsb pdb:4F00|rcsb pdb:4F01|rcsb pdb:4HY9|rcsb pdb:4HYB|rcsb pdb:4JN4|rcsb pdb:4JNE|rcsb pdb:4JNF|rcsb pdb:4JWC|rcsb pdb:4JWD|rcsb pdb:4JWE|rcsb pdb:4JWI|rcsb pdb:4R5G|rcsb pdb:4R5I|rcsb pdb:4R5J|rcsb pdb:4R5K|rcsb pdb:4R5L|rcsb pdb:5NRO|rcsb pdb:5OOW|rcsb pdb:7JMM|rcsb pdb:7JN8|rcsb pdb:7JN9|rcsb pdb:7JNE|rcsb pdb:7N6J|rcsb pdb:7N6K|rcsb pdb:7N6L|rcsb pdb:7N6M|rcsb pdb:4EZQ|refseq:WP_000516135.1|mint:P0A6Y8|dip:DIP-35751N refseq:NP_001020329.1|refseq:NP_001020330.1|refseq:NP_004346.1|ensembl:ENSG00000019582(gene)|ensembl:ENST00000009530(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001961"(positive regulation of cytokine-mediated signaling pathway)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0002606"(positive regulation of dendritic cell antigen processing and presentation)|go:"GO:0002792"(negative regulation of peptide secretion)|go:"GO:0002830"(positive regulation of type 2 immune response)|go:"GO:0002906"(negative regulation of mature B cell apoptotic process)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005773"(vacuole)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019883"(antigen processing and presentation of endogenous antigen)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0019955"(cytokine binding)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031394"(positive regulation of prostaglandin biosynthetic process)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0035691"(macrophage migration inhibitory factor signaling pathway)|go:"GO:0035692"(macrophage migration inhibitory factor receptor complex)|go:"GO:0035693"(NOS2-CD74 complex)|go:"GO:0035718"(macrophage migration inhibitory factor binding)|go:"GO:0042289"(MHC class II protein binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0042658"(MHC class II protein binding, via antigen binding groove)|go:"GO:0042802"(identical protein binding)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045058"(T cell selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045581"(negative regulation of T cell differentiation)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000448"(positive regulation of macrophage migration inhibitory factor signaling pathway)|interpro:IPR000716(Thyroglobulin type-1)|interpro:IPR011988(MHC class II-associated invariant chain, trimerisation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR015386(MHC class II-associated invariant chain/CLIP, MHC II-interacting)|interpro:IPR022339|interpro:IPR036613|go:"GO:0046597"(negative regulation of viral entry into host cell)|interpro:IPR036857|interpro:IPR043530|mint:P04233|rcsb pdb:1A6A|rcsb pdb:1ICF|rcsb pdb:1IIE|rcsb pdb:1L3H|rcsb pdb:1MUJ|rcsb pdb:3PDO|rcsb pdb:3PGC|rcsb pdb:3PGD|go:"GO:0046598"(positive regulation of viral entry into host cell)|rcsb pdb:3QXA|go:"GO:0048146"(positive regulation of fibroblast proliferation)|rcsb pdb:3QXD|rcsb pdb:4AEN|rcsb pdb:4AH2|rcsb pdb:4X5W|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|rcsb pdb:5KSU|rcsb pdb:5KSV|go:"GO:0050821"(protein stabilization)|reactome:R-HSA-202733|reactome:R-HSA-2132295|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070206"(protein trimerization)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade) - - - figure legend:2A|comment:The DRB1*0402 peptide did not inhibit binding, but all other peptides tested did.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/20 2017/04/11 rogid:jm8ErX3H3EOAYYuSDcddoE/NQx483333 rogid:jP1UH09kpXY45O7Qr5OdAfDDIXY9606 rigid:CDgHJV5M4P1skZFsvqD7JQLV6fk false - sufficient binding region:105-117|biotin tag:?-? - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation) uniprotkb:P0A6Y8 uniprotkb:P04233 intact:EBI-542092|uniprotkb:P04475|ensemblbacteria:AAC73125|ensemblbacteria:BAB96589 intact:EBI-2622890|uniprotkb:D3DQG3|uniprotkb:D3DQG4|uniprotkb:A8K7R1|uniprotkb:B4DNE8|uniprotkb:Q29832|uniprotkb:Q14597|uniprotkb:Q8SNA0|uniprotkb:Q8WLP6|uniprotkb:Q5U0J8|ensembl:ENSP00000009530 psi-mi:dnak_ecoli(display_long)|uniprotkb:dnaK(gene name)|psi-mi:dnaK(display_short)|uniprotkb:groP(gene name synonym)|uniprotkb:grpF(gene name synonym)|uniprotkb:seg(gene name synonym)|uniprotkb:b0014(locus name)|uniprotkb:Heat shock protein 70(gene name synonym)|uniprotkb:Heat shock 70 kDa protein(gene name synonym)|uniprotkb:HSP70(gene name synonym)|uniprotkb:JW0013(locus name) psi-mi:hg2a_human(display_long)|uniprotkb:DHLAG(gene name synonym)|uniprotkb:HLA-DR antigens-associated invariant chain(gene name synonym)|uniprotkb:Ia antigen-associated invariant chain(gene name synonym)|uniprotkb:CD74(gene name)|psi-mi:CD74(display_short) psi-mi:"MI:0892"(solid phase assay) Haug et al. (2007) imex:IM-25683|pubmed:17357109 taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13952570|imex:IM-25683-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_414555.1|ensemblbacteria:AAC73125(transcript)|ensemblbacteria:b0014(gene)|ensemblbacteria:BAB96589(gene)|ensemblbacteria:BAB96589(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006260"(DNA replication)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009408"(response to heat)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016989"(sigma factor antagonist activity)|go:"GO:0032984"(protein-containing complex disassembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0043531"(ADP binding)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR012725(Chaperone DnaK)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|rcsb pdb:1BPR|rcsb pdb:1DG4|rcsb pdb:1DKG|rcsb pdb:1DKX|rcsb pdb:1DKY|rcsb pdb:1DKZ|rcsb pdb:1Q5L|rcsb pdb:2BPR|rcsb pdb:2KHO|rcsb pdb:3DPO|rcsb pdb:3DPP|rcsb pdb:3DPQ|rcsb pdb:3QNJ|rcsb pdb:4B9Q|rcsb pdb:4E81|rcsb pdb:4EZN|rcsb pdb:4EZO|rcsb pdb:4EZP|rcsb pdb:4EZR|rcsb pdb:4EZS|rcsb pdb:4EZT|rcsb pdb:4EZU|rcsb pdb:4EZV|rcsb pdb:4EZW|rcsb pdb:4EZX|rcsb pdb:4EZY|rcsb pdb:4EZZ|rcsb pdb:4F00|rcsb pdb:4F01|rcsb pdb:4HY9|rcsb pdb:4HYB|rcsb pdb:4JN4|rcsb pdb:4JNE|rcsb pdb:4JNF|rcsb pdb:4JWC|rcsb pdb:4JWD|rcsb pdb:4JWE|rcsb pdb:4JWI|rcsb pdb:4R5G|rcsb pdb:4R5I|rcsb pdb:4R5J|rcsb pdb:4R5K|rcsb pdb:4R5L|rcsb pdb:5NRO|rcsb pdb:5OOW|rcsb pdb:7JMM|rcsb pdb:7JN8|rcsb pdb:7JN9|rcsb pdb:7JNE|rcsb pdb:7N6J|rcsb pdb:7N6K|rcsb pdb:7N6L|rcsb pdb:7N6M|rcsb pdb:4EZQ|refseq:WP_000516135.1|mint:P0A6Y8|dip:DIP-35751N refseq:NP_001020329.1|refseq:NP_001020330.1|refseq:NP_004346.1|ensembl:ENSG00000019582(gene)|ensembl:ENST00000009530(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001961"(positive regulation of cytokine-mediated signaling pathway)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0002606"(positive regulation of dendritic cell antigen processing and presentation)|go:"GO:0002792"(negative regulation of peptide secretion)|go:"GO:0002830"(positive regulation of type 2 immune response)|go:"GO:0002906"(negative regulation of mature B cell apoptotic process)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005773"(vacuole)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019883"(antigen processing and presentation of endogenous antigen)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0019955"(cytokine binding)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031394"(positive regulation of prostaglandin biosynthetic process)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0035691"(macrophage migration inhibitory factor signaling pathway)|go:"GO:0035692"(macrophage migration inhibitory factor receptor complex)|go:"GO:0035693"(NOS2-CD74 complex)|go:"GO:0035718"(macrophage migration inhibitory factor binding)|go:"GO:0042289"(MHC class II protein binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0042658"(MHC class II protein binding, via antigen binding groove)|go:"GO:0042802"(identical protein binding)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045058"(T cell selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045581"(negative regulation of T cell differentiation)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000448"(positive regulation of macrophage migration inhibitory factor signaling pathway)|interpro:IPR000716(Thyroglobulin type-1)|interpro:IPR011988(MHC class II-associated invariant chain, trimerisation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR015386(MHC class II-associated invariant chain/CLIP, MHC II-interacting)|interpro:IPR022339|interpro:IPR036613|go:"GO:0046597"(negative regulation of viral entry into host cell)|interpro:IPR036857|interpro:IPR043530|mint:P04233|rcsb pdb:1A6A|rcsb pdb:1ICF|rcsb pdb:1IIE|rcsb pdb:1L3H|rcsb pdb:1MUJ|rcsb pdb:3PDO|rcsb pdb:3PGC|rcsb pdb:3PGD|go:"GO:0046598"(positive regulation of viral entry into host cell)|rcsb pdb:3QXA|go:"GO:0048146"(positive regulation of fibroblast proliferation)|rcsb pdb:3QXD|rcsb pdb:4AEN|rcsb pdb:4AH2|rcsb pdb:4X5W|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|rcsb pdb:5KSU|rcsb pdb:5KSV|go:"GO:0050821"(protein stabilization)|reactome:R-HSA-202733|reactome:R-HSA-2132295|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070206"(protein trimerization)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade) - - - figure legend:2A-7|comment:"Inhibitor:HLA-DRB1*0801 allele"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/20 2020/01/09 rogid:jm8ErX3H3EOAYYuSDcddoE/NQx483333 rogid:jP1UH09kpXY45O7Qr5OdAfDDIXY9606 rigid:oG7rUlwrETaTVrKoP7D0j7mxgAo false - sufficient binding region:105-117 - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation) uniprotkb:P0A6Y8 uniprotkb:A0A0G4PYZ0 intact:EBI-542092|uniprotkb:P04475|ensemblbacteria:AAC73125|ensemblbacteria:BAB96589 intact:EBI-25339717 psi-mi:dnak_ecoli(display_long)|uniprotkb:dnaK(gene name)|psi-mi:dnaK(display_short)|uniprotkb:groP(gene name synonym)|uniprotkb:grpF(gene name synonym)|uniprotkb:seg(gene name synonym)|uniprotkb:b0014(locus name)|uniprotkb:Heat shock protein 70(gene name synonym)|uniprotkb:Heat shock 70 kDa protein(gene name synonym)|uniprotkb:HSP70(gene name synonym)|uniprotkb:JW0013(locus name) psi-mi:a0a0g4pyz0_human(display_long)|uniprotkb:HLA-DRB1(gene name)|psi-mi:HLA-DRB1(display_short) psi-mi:"MI:0892"(solid phase assay) Haug et al. (2007) imex:IM-25683|pubmed:17357109 taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13952570|imex:IM-25683-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0586"(inhibitor) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_414555.1|ensemblbacteria:AAC73125(transcript)|ensemblbacteria:b0014(gene)|ensemblbacteria:BAB96589(gene)|ensemblbacteria:BAB96589(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006260"(DNA replication)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009408"(response to heat)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016989"(sigma factor antagonist activity)|go:"GO:0032984"(protein-containing complex disassembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0043531"(ADP binding)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR012725(Chaperone DnaK)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|rcsb pdb:1BPR|rcsb pdb:1DG4|rcsb pdb:1DKG|rcsb pdb:1DKX|rcsb pdb:1DKY|rcsb pdb:1DKZ|rcsb pdb:1Q5L|rcsb pdb:2BPR|rcsb pdb:2KHO|rcsb pdb:3DPO|rcsb pdb:3DPP|rcsb pdb:3DPQ|rcsb pdb:3QNJ|rcsb pdb:4B9Q|rcsb pdb:4E81|rcsb pdb:4EZN|rcsb pdb:4EZO|rcsb pdb:4EZP|rcsb pdb:4EZR|rcsb pdb:4EZS|rcsb pdb:4EZT|rcsb pdb:4EZU|rcsb pdb:4EZV|rcsb pdb:4EZW|rcsb pdb:4EZX|rcsb pdb:4EZY|rcsb pdb:4EZZ|rcsb pdb:4F00|rcsb pdb:4F01|rcsb pdb:4HY9|rcsb pdb:4HYB|rcsb pdb:4JN4|rcsb pdb:4JNE|rcsb pdb:4JNF|rcsb pdb:4JWC|rcsb pdb:4JWD|rcsb pdb:4JWE|rcsb pdb:4JWI|rcsb pdb:4R5G|rcsb pdb:4R5I|rcsb pdb:4R5J|rcsb pdb:4R5K|rcsb pdb:4R5L|rcsb pdb:5NRO|rcsb pdb:5OOW|rcsb pdb:7JMM|rcsb pdb:7JN8|rcsb pdb:7JN9|rcsb pdb:7JNE|rcsb pdb:7N6J|rcsb pdb:7N6K|rcsb pdb:7N6L|rcsb pdb:7N6M|rcsb pdb:4EZQ|refseq:WP_000516135.1|mint:P0A6Y8|dip:DIP-35751N interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR000353(MHC class II, beta chain, N-terminal) - - no-uniprot-update: figure legend:2A-7|comment:"Inhibitor:HLA-DRB1*0801 allele"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/20 2020/01/09 rogid:jm8ErX3H3EOAYYuSDcddoE/NQx483333 rogid:2b6WKV5vcA/AaS5iDadYN7Pfcl49606 rigid:oG7rUlwrETaTVrKoP7D0j7mxgAo false - sufficient binding region:94-106|biotin tag:?-? - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation) uniprotkb:P0A6Y8 uniprotkb:A0A1V1IGJ9 intact:EBI-542092|uniprotkb:P04475|ensemblbacteria:AAC73125|ensemblbacteria:BAB96589 intact:EBI-25339774 psi-mi:dnak_ecoli(display_long)|uniprotkb:dnaK(gene name)|psi-mi:dnaK(display_short)|uniprotkb:groP(gene name synonym)|uniprotkb:grpF(gene name synonym)|uniprotkb:seg(gene name synonym)|uniprotkb:b0014(locus name)|uniprotkb:Heat shock protein 70(gene name synonym)|uniprotkb:Heat shock 70 kDa protein(gene name synonym)|uniprotkb:HSP70(gene name synonym)|uniprotkb:JW0013(locus name) psi-mi:a0a1v1igj9_human(display_long)|uniprotkb:HLA-DRB1(gene name)|psi-mi:HLA-DRB1(display_short) psi-mi:"MI:0892"(solid phase assay) Haug et al. (2007) imex:IM-25683|pubmed:17357109 taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13952584|imex:IM-25683-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0586"(inhibitor) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_414555.1|ensemblbacteria:AAC73125(transcript)|ensemblbacteria:b0014(gene)|ensemblbacteria:BAB96589(gene)|ensemblbacteria:BAB96589(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006260"(DNA replication)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009408"(response to heat)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016989"(sigma factor antagonist activity)|go:"GO:0032984"(protein-containing complex disassembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0043531"(ADP binding)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR012725(Chaperone DnaK)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|rcsb pdb:1BPR|rcsb pdb:1DG4|rcsb pdb:1DKG|rcsb pdb:1DKX|rcsb pdb:1DKY|rcsb pdb:1DKZ|rcsb pdb:1Q5L|rcsb pdb:2BPR|rcsb pdb:2KHO|rcsb pdb:3DPO|rcsb pdb:3DPP|rcsb pdb:3DPQ|rcsb pdb:3QNJ|rcsb pdb:4B9Q|rcsb pdb:4E81|rcsb pdb:4EZN|rcsb pdb:4EZO|rcsb pdb:4EZP|rcsb pdb:4EZR|rcsb pdb:4EZS|rcsb pdb:4EZT|rcsb pdb:4EZU|rcsb pdb:4EZV|rcsb pdb:4EZW|rcsb pdb:4EZX|rcsb pdb:4EZY|rcsb pdb:4EZZ|rcsb pdb:4F00|rcsb pdb:4F01|rcsb pdb:4HY9|rcsb pdb:4HYB|rcsb pdb:4JN4|rcsb pdb:4JNE|rcsb pdb:4JNF|rcsb pdb:4JWC|rcsb pdb:4JWD|rcsb pdb:4JWE|rcsb pdb:4JWI|rcsb pdb:4R5G|rcsb pdb:4R5I|rcsb pdb:4R5J|rcsb pdb:4R5K|rcsb pdb:4R5L|rcsb pdb:5NRO|rcsb pdb:5OOW|rcsb pdb:7JMM|rcsb pdb:7JN8|rcsb pdb:7JN9|rcsb pdb:7JNE|rcsb pdb:7N6J|rcsb pdb:7N6K|rcsb pdb:7N6L|rcsb pdb:7N6M|rcsb pdb:4EZQ|refseq:WP_000516135.1|mint:P0A6Y8|dip:DIP-35751N interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR000353(MHC class II, beta chain, N-terminal) - - no-uniprot-update: figure legend:2A-1|comment:"Inhibitor: HLA-DRB1*0401"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/20 2020/01/09 rogid:jm8ErX3H3EOAYYuSDcddoE/NQx483333 rogid:t0oiEebDmTMAhQ97YLbgIkwvFek9606 rigid:Eyy/O8q8ZDosgTHK+0fGj5nb2+A false - sufficient binding region:94-106 - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation) uniprotkb:P0A6Y8 uniprotkb:P04233 intact:EBI-542092|uniprotkb:P04475|ensemblbacteria:AAC73125|ensemblbacteria:BAB96589 intact:EBI-2622890|uniprotkb:D3DQG3|uniprotkb:D3DQG4|uniprotkb:A8K7R1|uniprotkb:B4DNE8|uniprotkb:Q29832|uniprotkb:Q14597|uniprotkb:Q8SNA0|uniprotkb:Q8WLP6|uniprotkb:Q5U0J8|ensembl:ENSP00000009530 psi-mi:dnak_ecoli(display_long)|uniprotkb:dnaK(gene name)|psi-mi:dnaK(display_short)|uniprotkb:groP(gene name synonym)|uniprotkb:grpF(gene name synonym)|uniprotkb:seg(gene name synonym)|uniprotkb:b0014(locus name)|uniprotkb:Heat shock protein 70(gene name synonym)|uniprotkb:Heat shock 70 kDa protein(gene name synonym)|uniprotkb:HSP70(gene name synonym)|uniprotkb:JW0013(locus name) psi-mi:hg2a_human(display_long)|uniprotkb:DHLAG(gene name synonym)|uniprotkb:HLA-DR antigens-associated invariant chain(gene name synonym)|uniprotkb:Ia antigen-associated invariant chain(gene name synonym)|uniprotkb:CD74(gene name)|psi-mi:CD74(display_short) psi-mi:"MI:0892"(solid phase assay) Haug et al. (2007) imex:IM-25683|pubmed:17357109 taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13952584|imex:IM-25683-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_414555.1|ensemblbacteria:AAC73125(transcript)|ensemblbacteria:b0014(gene)|ensemblbacteria:BAB96589(gene)|ensemblbacteria:BAB96589(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006260"(DNA replication)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009408"(response to heat)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016989"(sigma factor antagonist activity)|go:"GO:0032984"(protein-containing complex disassembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0043531"(ADP binding)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR012725(Chaperone DnaK)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|rcsb pdb:1BPR|rcsb pdb:1DG4|rcsb pdb:1DKG|rcsb pdb:1DKX|rcsb pdb:1DKY|rcsb pdb:1DKZ|rcsb pdb:1Q5L|rcsb pdb:2BPR|rcsb pdb:2KHO|rcsb pdb:3DPO|rcsb pdb:3DPP|rcsb pdb:3DPQ|rcsb pdb:3QNJ|rcsb pdb:4B9Q|rcsb pdb:4E81|rcsb pdb:4EZN|rcsb pdb:4EZO|rcsb pdb:4EZP|rcsb pdb:4EZR|rcsb pdb:4EZS|rcsb pdb:4EZT|rcsb pdb:4EZU|rcsb pdb:4EZV|rcsb pdb:4EZW|rcsb pdb:4EZX|rcsb pdb:4EZY|rcsb pdb:4EZZ|rcsb pdb:4F00|rcsb pdb:4F01|rcsb pdb:4HY9|rcsb pdb:4HYB|rcsb pdb:4JN4|rcsb pdb:4JNE|rcsb pdb:4JNF|rcsb pdb:4JWC|rcsb pdb:4JWD|rcsb pdb:4JWE|rcsb pdb:4JWI|rcsb pdb:4R5G|rcsb pdb:4R5I|rcsb pdb:4R5J|rcsb pdb:4R5K|rcsb pdb:4R5L|rcsb pdb:5NRO|rcsb pdb:5OOW|rcsb pdb:7JMM|rcsb pdb:7JN8|rcsb pdb:7JN9|rcsb pdb:7JNE|rcsb pdb:7N6J|rcsb pdb:7N6K|rcsb pdb:7N6L|rcsb pdb:7N6M|rcsb pdb:4EZQ|refseq:WP_000516135.1|mint:P0A6Y8|dip:DIP-35751N refseq:NP_001020329.1|refseq:NP_001020330.1|refseq:NP_004346.1|ensembl:ENSG00000019582(gene)|ensembl:ENST00000009530(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001961"(positive regulation of cytokine-mediated signaling pathway)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0002606"(positive regulation of dendritic cell antigen processing and presentation)|go:"GO:0002792"(negative regulation of peptide secretion)|go:"GO:0002830"(positive regulation of type 2 immune response)|go:"GO:0002906"(negative regulation of mature B cell apoptotic process)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005773"(vacuole)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019883"(antigen processing and presentation of endogenous antigen)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0019955"(cytokine binding)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031394"(positive regulation of prostaglandin biosynthetic process)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0035691"(macrophage migration inhibitory factor signaling pathway)|go:"GO:0035692"(macrophage migration inhibitory factor receptor complex)|go:"GO:0035693"(NOS2-CD74 complex)|go:"GO:0035718"(macrophage migration inhibitory factor binding)|go:"GO:0042289"(MHC class II protein binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0042658"(MHC class II protein binding, via antigen binding groove)|go:"GO:0042802"(identical protein binding)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045058"(T cell selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045581"(negative regulation of T cell differentiation)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000448"(positive regulation of macrophage migration inhibitory factor signaling pathway)|interpro:IPR000716(Thyroglobulin type-1)|interpro:IPR011988(MHC class II-associated invariant chain, trimerisation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR015386(MHC class II-associated invariant chain/CLIP, MHC II-interacting)|interpro:IPR022339|interpro:IPR036613|go:"GO:0046597"(negative regulation of viral entry into host cell)|interpro:IPR036857|interpro:IPR043530|mint:P04233|rcsb pdb:1A6A|rcsb pdb:1ICF|rcsb pdb:1IIE|rcsb pdb:1L3H|rcsb pdb:1MUJ|rcsb pdb:3PDO|rcsb pdb:3PGC|rcsb pdb:3PGD|go:"GO:0046598"(positive regulation of viral entry into host cell)|rcsb pdb:3QXA|go:"GO:0048146"(positive regulation of fibroblast proliferation)|rcsb pdb:3QXD|rcsb pdb:4AEN|rcsb pdb:4AH2|rcsb pdb:4X5W|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|rcsb pdb:5KSU|rcsb pdb:5KSV|go:"GO:0050821"(protein stabilization)|reactome:R-HSA-202733|reactome:R-HSA-2132295|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070206"(protein trimerization)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade) - - - figure legend:2A-1|comment:"Inhibitor: HLA-DRB1*0401"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/20 2020/01/09 rogid:jm8ErX3H3EOAYYuSDcddoE/NQx483333 rogid:jP1UH09kpXY45O7Qr5OdAfDDIXY9606 rigid:Eyy/O8q8ZDosgTHK+0fGj5nb2+A false - sufficient binding region:105-117|biotin tag:?-? - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation) uniprotkb:P0A6Y8 uniprotkb:D7RIG0 intact:EBI-542092|uniprotkb:P04475|ensemblbacteria:AAC73125|ensemblbacteria:BAB96589 intact:EBI-25339681 psi-mi:dnak_ecoli(display_long)|uniprotkb:dnaK(gene name)|psi-mi:dnaK(display_short)|uniprotkb:groP(gene name synonym)|uniprotkb:grpF(gene name synonym)|uniprotkb:seg(gene name synonym)|uniprotkb:b0014(locus name)|uniprotkb:Heat shock protein 70(gene name synonym)|uniprotkb:Heat shock 70 kDa protein(gene name synonym)|uniprotkb:HSP70(gene name synonym)|uniprotkb:JW0013(locus name) psi-mi:d7rig0_human(display_long)|uniprotkb:HLA-DRB1(gene name)|psi-mi:HLA-DRB1(display_short) psi-mi:"MI:0892"(solid phase assay) Haug et al. (2007) imex:IM-25683|pubmed:17357109 taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13952637|imex:IM-25683-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0586"(inhibitor) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_414555.1|ensemblbacteria:AAC73125(transcript)|ensemblbacteria:b0014(gene)|ensemblbacteria:BAB96589(gene)|ensemblbacteria:BAB96589(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006260"(DNA replication)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009408"(response to heat)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016989"(sigma factor antagonist activity)|go:"GO:0032984"(protein-containing complex disassembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0043531"(ADP binding)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR012725(Chaperone DnaK)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|rcsb pdb:1BPR|rcsb pdb:1DG4|rcsb pdb:1DKG|rcsb pdb:1DKX|rcsb pdb:1DKY|rcsb pdb:1DKZ|rcsb pdb:1Q5L|rcsb pdb:2BPR|rcsb pdb:2KHO|rcsb pdb:3DPO|rcsb pdb:3DPP|rcsb pdb:3DPQ|rcsb pdb:3QNJ|rcsb pdb:4B9Q|rcsb pdb:4E81|rcsb pdb:4EZN|rcsb pdb:4EZO|rcsb pdb:4EZP|rcsb pdb:4EZR|rcsb pdb:4EZS|rcsb pdb:4EZT|rcsb pdb:4EZU|rcsb pdb:4EZV|rcsb pdb:4EZW|rcsb pdb:4EZX|rcsb pdb:4EZY|rcsb pdb:4EZZ|rcsb pdb:4F00|rcsb pdb:4F01|rcsb pdb:4HY9|rcsb pdb:4HYB|rcsb pdb:4JN4|rcsb pdb:4JNE|rcsb pdb:4JNF|rcsb pdb:4JWC|rcsb pdb:4JWD|rcsb pdb:4JWE|rcsb pdb:4JWI|rcsb pdb:4R5G|rcsb pdb:4R5I|rcsb pdb:4R5J|rcsb pdb:4R5K|rcsb pdb:4R5L|rcsb pdb:5NRO|rcsb pdb:5OOW|rcsb pdb:7JMM|rcsb pdb:7JN8|rcsb pdb:7JN9|rcsb pdb:7JNE|rcsb pdb:7N6J|rcsb pdb:7N6K|rcsb pdb:7N6L|rcsb pdb:7N6M|rcsb pdb:4EZQ|refseq:WP_000516135.1|mint:P0A6Y8|dip:DIP-35751N go:"GO:0016021"(integral component of membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002504"(antigen processing and presentation of peptide or polysaccharide antigen via MHC class II)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR000353(MHC class II, beta chain, N-terminal) - - no-uniprot-update: figure legend:2A-4|comment:"Inhibitor: HLA-DRB1*0101"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/20 2020/01/09 rogid:jm8ErX3H3EOAYYuSDcddoE/NQx483333 rogid:vCNdHdbtlKcoI2NPKfDiiFm88sQ9606 rigid:eQpcuMBpRWb6z385Bf+TWuYalqw false - sufficient binding region:94-106 - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation) uniprotkb:P0A6Y8 uniprotkb:P04233 intact:EBI-542092|uniprotkb:P04475|ensemblbacteria:AAC73125|ensemblbacteria:BAB96589 intact:EBI-2622890|uniprotkb:D3DQG3|uniprotkb:D3DQG4|uniprotkb:A8K7R1|uniprotkb:B4DNE8|uniprotkb:Q29832|uniprotkb:Q14597|uniprotkb:Q8SNA0|uniprotkb:Q8WLP6|uniprotkb:Q5U0J8|ensembl:ENSP00000009530 psi-mi:dnak_ecoli(display_long)|uniprotkb:dnaK(gene name)|psi-mi:dnaK(display_short)|uniprotkb:groP(gene name synonym)|uniprotkb:grpF(gene name synonym)|uniprotkb:seg(gene name synonym)|uniprotkb:b0014(locus name)|uniprotkb:Heat shock protein 70(gene name synonym)|uniprotkb:Heat shock 70 kDa protein(gene name synonym)|uniprotkb:HSP70(gene name synonym)|uniprotkb:JW0013(locus name) psi-mi:hg2a_human(display_long)|uniprotkb:DHLAG(gene name synonym)|uniprotkb:HLA-DR antigens-associated invariant chain(gene name synonym)|uniprotkb:Ia antigen-associated invariant chain(gene name synonym)|uniprotkb:CD74(gene name)|psi-mi:CD74(display_short) psi-mi:"MI:0892"(solid phase assay) Haug et al. (2007) imex:IM-25683|pubmed:17357109 taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13952637|imex:IM-25683-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_414555.1|ensemblbacteria:AAC73125(transcript)|ensemblbacteria:b0014(gene)|ensemblbacteria:BAB96589(gene)|ensemblbacteria:BAB96589(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006260"(DNA replication)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009408"(response to heat)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016989"(sigma factor antagonist activity)|go:"GO:0032984"(protein-containing complex disassembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0043531"(ADP binding)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR012725(Chaperone DnaK)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|rcsb pdb:1BPR|rcsb pdb:1DG4|rcsb pdb:1DKG|rcsb pdb:1DKX|rcsb pdb:1DKY|rcsb pdb:1DKZ|rcsb pdb:1Q5L|rcsb pdb:2BPR|rcsb pdb:2KHO|rcsb pdb:3DPO|rcsb pdb:3DPP|rcsb pdb:3DPQ|rcsb pdb:3QNJ|rcsb pdb:4B9Q|rcsb pdb:4E81|rcsb pdb:4EZN|rcsb pdb:4EZO|rcsb pdb:4EZP|rcsb pdb:4EZR|rcsb pdb:4EZS|rcsb pdb:4EZT|rcsb pdb:4EZU|rcsb pdb:4EZV|rcsb pdb:4EZW|rcsb pdb:4EZX|rcsb pdb:4EZY|rcsb pdb:4EZZ|rcsb pdb:4F00|rcsb pdb:4F01|rcsb pdb:4HY9|rcsb pdb:4HYB|rcsb pdb:4JN4|rcsb pdb:4JNE|rcsb pdb:4JNF|rcsb pdb:4JWC|rcsb pdb:4JWD|rcsb pdb:4JWE|rcsb pdb:4JWI|rcsb pdb:4R5G|rcsb pdb:4R5I|rcsb pdb:4R5J|rcsb pdb:4R5K|rcsb pdb:4R5L|rcsb pdb:5NRO|rcsb pdb:5OOW|rcsb pdb:7JMM|rcsb pdb:7JN8|rcsb pdb:7JN9|rcsb pdb:7JNE|rcsb pdb:7N6J|rcsb pdb:7N6K|rcsb pdb:7N6L|rcsb pdb:7N6M|rcsb pdb:4EZQ|refseq:WP_000516135.1|mint:P0A6Y8|dip:DIP-35751N refseq:NP_001020329.1|refseq:NP_001020330.1|refseq:NP_004346.1|ensembl:ENSG00000019582(gene)|ensembl:ENST00000009530(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001961"(positive regulation of cytokine-mediated signaling pathway)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0002606"(positive regulation of dendritic cell antigen processing and presentation)|go:"GO:0002792"(negative regulation of peptide secretion)|go:"GO:0002830"(positive regulation of type 2 immune response)|go:"GO:0002906"(negative regulation of mature B cell apoptotic process)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005773"(vacuole)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019883"(antigen processing and presentation of endogenous antigen)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0019955"(cytokine binding)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031394"(positive regulation of prostaglandin biosynthetic process)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0035691"(macrophage migration inhibitory factor signaling pathway)|go:"GO:0035692"(macrophage migration inhibitory factor receptor complex)|go:"GO:0035693"(NOS2-CD74 complex)|go:"GO:0035718"(macrophage migration inhibitory factor binding)|go:"GO:0042289"(MHC class II protein binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0042658"(MHC class II protein binding, via antigen binding groove)|go:"GO:0042802"(identical protein binding)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045058"(T cell selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045581"(negative regulation of T cell differentiation)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000448"(positive regulation of macrophage migration inhibitory factor signaling pathway)|interpro:IPR000716(Thyroglobulin type-1)|interpro:IPR011988(MHC class II-associated invariant chain, trimerisation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR015386(MHC class II-associated invariant chain/CLIP, MHC II-interacting)|interpro:IPR022339|interpro:IPR036613|go:"GO:0046597"(negative regulation of viral entry into host cell)|interpro:IPR036857|interpro:IPR043530|mint:P04233|rcsb pdb:1A6A|rcsb pdb:1ICF|rcsb pdb:1IIE|rcsb pdb:1L3H|rcsb pdb:1MUJ|rcsb pdb:3PDO|rcsb pdb:3PGC|rcsb pdb:3PGD|go:"GO:0046598"(positive regulation of viral entry into host cell)|rcsb pdb:3QXA|go:"GO:0048146"(positive regulation of fibroblast proliferation)|rcsb pdb:3QXD|rcsb pdb:4AEN|rcsb pdb:4AH2|rcsb pdb:4X5W|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|rcsb pdb:5KSU|rcsb pdb:5KSV|go:"GO:0050821"(protein stabilization)|reactome:R-HSA-202733|reactome:R-HSA-2132295|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070206"(protein trimerization)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade) - - - figure legend:2A-4|comment:"Inhibitor: HLA-DRB1*0101"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/20 2020/01/09 rogid:jm8ErX3H3EOAYYuSDcddoE/NQx483333 rogid:jP1UH09kpXY45O7Qr5OdAfDDIXY9606 rigid:eQpcuMBpRWb6z385Bf+TWuYalqw false - sufficient binding region:105-117|biotin tag:?-? - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation) uniprotkb:P0A6Y8 uniprotkb:Q0R326 intact:EBI-542092|uniprotkb:P04475|ensemblbacteria:AAC73125|ensemblbacteria:BAB96589 intact:EBI-25339756 psi-mi:dnak_ecoli(display_long)|uniprotkb:dnaK(gene name)|psi-mi:dnaK(display_short)|uniprotkb:groP(gene name synonym)|uniprotkb:grpF(gene name synonym)|uniprotkb:seg(gene name synonym)|uniprotkb:b0014(locus name)|uniprotkb:Heat shock protein 70(gene name synonym)|uniprotkb:Heat shock 70 kDa protein(gene name synonym)|uniprotkb:HSP70(gene name synonym)|uniprotkb:JW0013(locus name) psi-mi:q0r326_human(display_long)|uniprotkb:HLA-DRB1(gene name)|psi-mi:HLA-DRB1(display_short)|uniprotkb:HLA-DRB5(gene name synonym)|uniprotkb:hCG_1998957(orf name) psi-mi:"MI:0892"(solid phase assay) Haug et al. (2007) imex:IM-25683|pubmed:17357109 taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13952657|imex:IM-25683-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0586"(inhibitor) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_414555.1|ensemblbacteria:AAC73125(transcript)|ensemblbacteria:b0014(gene)|ensemblbacteria:BAB96589(gene)|ensemblbacteria:BAB96589(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006260"(DNA replication)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009408"(response to heat)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016989"(sigma factor antagonist activity)|go:"GO:0032984"(protein-containing complex disassembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0043531"(ADP binding)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR012725(Chaperone DnaK)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|rcsb pdb:1BPR|rcsb pdb:1DG4|rcsb pdb:1DKG|rcsb pdb:1DKX|rcsb pdb:1DKY|rcsb pdb:1DKZ|rcsb pdb:1Q5L|rcsb pdb:2BPR|rcsb pdb:2KHO|rcsb pdb:3DPO|rcsb pdb:3DPP|rcsb pdb:3DPQ|rcsb pdb:3QNJ|rcsb pdb:4B9Q|rcsb pdb:4E81|rcsb pdb:4EZN|rcsb pdb:4EZO|rcsb pdb:4EZP|rcsb pdb:4EZR|rcsb pdb:4EZS|rcsb pdb:4EZT|rcsb pdb:4EZU|rcsb pdb:4EZV|rcsb pdb:4EZW|rcsb pdb:4EZX|rcsb pdb:4EZY|rcsb pdb:4EZZ|rcsb pdb:4F00|rcsb pdb:4F01|rcsb pdb:4HY9|rcsb pdb:4HYB|rcsb pdb:4JN4|rcsb pdb:4JNE|rcsb pdb:4JNF|rcsb pdb:4JWC|rcsb pdb:4JWD|rcsb pdb:4JWE|rcsb pdb:4JWI|rcsb pdb:4R5G|rcsb pdb:4R5I|rcsb pdb:4R5J|rcsb pdb:4R5K|rcsb pdb:4R5L|rcsb pdb:5NRO|rcsb pdb:5OOW|rcsb pdb:7JMM|rcsb pdb:7JN8|rcsb pdb:7JN9|rcsb pdb:7JNE|rcsb pdb:7N6J|rcsb pdb:7N6K|rcsb pdb:7N6L|rcsb pdb:7N6M|rcsb pdb:4EZQ|refseq:WP_000516135.1|mint:P0A6Y8|dip:DIP-35751N go:"GO:0016021"(integral component of membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002504"(antigen processing and presentation of peptide or polysaccharide antigen via MHC class II)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR000353(MHC class II, beta chain, N-terminal) - - no-uniprot-update: figure legend:2A-5|comment:"Inhibitor:HLA-DRB1*0901/DRB1*090102 allele (0901 sequence shown to contain errors and be identical to DRB1*09:01:02 (December 1996))."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/20 2020/01/09 rogid:jm8ErX3H3EOAYYuSDcddoE/NQx483333 rogid:Gq4S+WP70PV3KhQds27aWYtFaB09606 rigid:rtKh8ScGmyJZEtIl7KWq24/hyJY false - sufficient binding region:94-106 - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation) uniprotkb:P0A6Y8 uniprotkb:P04233 intact:EBI-542092|uniprotkb:P04475|ensemblbacteria:AAC73125|ensemblbacteria:BAB96589 intact:EBI-2622890|uniprotkb:D3DQG3|uniprotkb:D3DQG4|uniprotkb:A8K7R1|uniprotkb:B4DNE8|uniprotkb:Q29832|uniprotkb:Q14597|uniprotkb:Q8SNA0|uniprotkb:Q8WLP6|uniprotkb:Q5U0J8|ensembl:ENSP00000009530 psi-mi:dnak_ecoli(display_long)|uniprotkb:dnaK(gene name)|psi-mi:dnaK(display_short)|uniprotkb:groP(gene name synonym)|uniprotkb:grpF(gene name synonym)|uniprotkb:seg(gene name synonym)|uniprotkb:b0014(locus name)|uniprotkb:Heat shock protein 70(gene name synonym)|uniprotkb:Heat shock 70 kDa protein(gene name synonym)|uniprotkb:HSP70(gene name synonym)|uniprotkb:JW0013(locus name) psi-mi:hg2a_human(display_long)|uniprotkb:DHLAG(gene name synonym)|uniprotkb:HLA-DR antigens-associated invariant chain(gene name synonym)|uniprotkb:Ia antigen-associated invariant chain(gene name synonym)|uniprotkb:CD74(gene name)|psi-mi:CD74(display_short) psi-mi:"MI:0892"(solid phase assay) Haug et al. (2007) imex:IM-25683|pubmed:17357109 taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13952657|imex:IM-25683-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_414555.1|ensemblbacteria:AAC73125(transcript)|ensemblbacteria:b0014(gene)|ensemblbacteria:BAB96589(gene)|ensemblbacteria:BAB96589(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006260"(DNA replication)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009408"(response to heat)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016989"(sigma factor antagonist activity)|go:"GO:0032984"(protein-containing complex disassembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0043531"(ADP binding)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR012725(Chaperone DnaK)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|rcsb pdb:1BPR|rcsb pdb:1DG4|rcsb pdb:1DKG|rcsb pdb:1DKX|rcsb pdb:1DKY|rcsb pdb:1DKZ|rcsb pdb:1Q5L|rcsb pdb:2BPR|rcsb pdb:2KHO|rcsb pdb:3DPO|rcsb pdb:3DPP|rcsb pdb:3DPQ|rcsb pdb:3QNJ|rcsb pdb:4B9Q|rcsb pdb:4E81|rcsb pdb:4EZN|rcsb pdb:4EZO|rcsb pdb:4EZP|rcsb pdb:4EZR|rcsb pdb:4EZS|rcsb pdb:4EZT|rcsb pdb:4EZU|rcsb pdb:4EZV|rcsb pdb:4EZW|rcsb pdb:4EZX|rcsb pdb:4EZY|rcsb pdb:4EZZ|rcsb pdb:4F00|rcsb pdb:4F01|rcsb pdb:4HY9|rcsb pdb:4HYB|rcsb pdb:4JN4|rcsb pdb:4JNE|rcsb pdb:4JNF|rcsb pdb:4JWC|rcsb pdb:4JWD|rcsb pdb:4JWE|rcsb pdb:4JWI|rcsb pdb:4R5G|rcsb pdb:4R5I|rcsb pdb:4R5J|rcsb pdb:4R5K|rcsb pdb:4R5L|rcsb pdb:5NRO|rcsb pdb:5OOW|rcsb pdb:7JMM|rcsb pdb:7JN8|rcsb pdb:7JN9|rcsb pdb:7JNE|rcsb pdb:7N6J|rcsb pdb:7N6K|rcsb pdb:7N6L|rcsb pdb:7N6M|rcsb pdb:4EZQ|refseq:WP_000516135.1|mint:P0A6Y8|dip:DIP-35751N refseq:NP_001020329.1|refseq:NP_001020330.1|refseq:NP_004346.1|ensembl:ENSG00000019582(gene)|ensembl:ENST00000009530(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001961"(positive regulation of cytokine-mediated signaling pathway)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0002606"(positive regulation of dendritic cell antigen processing and presentation)|go:"GO:0002792"(negative regulation of peptide secretion)|go:"GO:0002830"(positive regulation of type 2 immune response)|go:"GO:0002906"(negative regulation of mature B cell apoptotic process)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005773"(vacuole)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019883"(antigen processing and presentation of endogenous antigen)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0019955"(cytokine binding)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031394"(positive regulation of prostaglandin biosynthetic process)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0035691"(macrophage migration inhibitory factor signaling pathway)|go:"GO:0035692"(macrophage migration inhibitory factor receptor complex)|go:"GO:0035693"(NOS2-CD74 complex)|go:"GO:0035718"(macrophage migration inhibitory factor binding)|go:"GO:0042289"(MHC class II protein binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0042658"(MHC class II protein binding, via antigen binding groove)|go:"GO:0042802"(identical protein binding)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045058"(T cell selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045581"(negative regulation of T cell differentiation)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000448"(positive regulation of macrophage migration inhibitory factor signaling pathway)|interpro:IPR000716(Thyroglobulin type-1)|interpro:IPR011988(MHC class II-associated invariant chain, trimerisation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR015386(MHC class II-associated invariant chain/CLIP, MHC II-interacting)|interpro:IPR022339|interpro:IPR036613|go:"GO:0046597"(negative regulation of viral entry into host cell)|interpro:IPR036857|interpro:IPR043530|mint:P04233|rcsb pdb:1A6A|rcsb pdb:1ICF|rcsb pdb:1IIE|rcsb pdb:1L3H|rcsb pdb:1MUJ|rcsb pdb:3PDO|rcsb pdb:3PGC|rcsb pdb:3PGD|go:"GO:0046598"(positive regulation of viral entry into host cell)|rcsb pdb:3QXA|go:"GO:0048146"(positive regulation of fibroblast proliferation)|rcsb pdb:3QXD|rcsb pdb:4AEN|rcsb pdb:4AH2|rcsb pdb:4X5W|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|rcsb pdb:5KSU|rcsb pdb:5KSV|go:"GO:0050821"(protein stabilization)|reactome:R-HSA-202733|reactome:R-HSA-2132295|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070206"(protein trimerization)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade) - - - figure legend:2A-5|comment:"Inhibitor:HLA-DRB1*0901/DRB1*090102 allele (0901 sequence shown to contain errors and be identical to DRB1*09:01:02 (December 1996))."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/20 2020/01/09 rogid:jm8ErX3H3EOAYYuSDcddoE/NQx483333 rogid:jP1UH09kpXY45O7Qr5OdAfDDIXY9606 rigid:rtKh8ScGmyJZEtIl7KWq24/hyJY false - sufficient binding region:105-117|biotin tag:?-? - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation) uniprotkb:P0A6Y8 uniprotkb:A0A1V1IGJ9 intact:EBI-542092|uniprotkb:P04475|ensemblbacteria:AAC73125|ensemblbacteria:BAB96589 intact:EBI-25339774 psi-mi:dnak_ecoli(display_long)|uniprotkb:dnaK(gene name)|psi-mi:dnaK(display_short)|uniprotkb:groP(gene name synonym)|uniprotkb:grpF(gene name synonym)|uniprotkb:seg(gene name synonym)|uniprotkb:b0014(locus name)|uniprotkb:Heat shock protein 70(gene name synonym)|uniprotkb:Heat shock 70 kDa protein(gene name synonym)|uniprotkb:HSP70(gene name synonym)|uniprotkb:JW0013(locus name) psi-mi:a0a1v1igj9_human(display_long)|uniprotkb:HLA-DRB1(gene name)|psi-mi:HLA-DRB1(display_short) psi-mi:"MI:0892"(solid phase assay) Haug et al. (2007) imex:IM-25683|pubmed:17357109 taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13952685|imex:IM-25683-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0586"(inhibitor) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_414555.1|ensemblbacteria:AAC73125(transcript)|ensemblbacteria:b0014(gene)|ensemblbacteria:BAB96589(gene)|ensemblbacteria:BAB96589(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006260"(DNA replication)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009408"(response to heat)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016989"(sigma factor antagonist activity)|go:"GO:0032984"(protein-containing complex disassembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0043531"(ADP binding)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR012725(Chaperone DnaK)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|rcsb pdb:1BPR|rcsb pdb:1DG4|rcsb pdb:1DKG|rcsb pdb:1DKX|rcsb pdb:1DKY|rcsb pdb:1DKZ|rcsb pdb:1Q5L|rcsb pdb:2BPR|rcsb pdb:2KHO|rcsb pdb:3DPO|rcsb pdb:3DPP|rcsb pdb:3DPQ|rcsb pdb:3QNJ|rcsb pdb:4B9Q|rcsb pdb:4E81|rcsb pdb:4EZN|rcsb pdb:4EZO|rcsb pdb:4EZP|rcsb pdb:4EZR|rcsb pdb:4EZS|rcsb pdb:4EZT|rcsb pdb:4EZU|rcsb pdb:4EZV|rcsb pdb:4EZW|rcsb pdb:4EZX|rcsb pdb:4EZY|rcsb pdb:4EZZ|rcsb pdb:4F00|rcsb pdb:4F01|rcsb pdb:4HY9|rcsb pdb:4HYB|rcsb pdb:4JN4|rcsb pdb:4JNE|rcsb pdb:4JNF|rcsb pdb:4JWC|rcsb pdb:4JWD|rcsb pdb:4JWE|rcsb pdb:4JWI|rcsb pdb:4R5G|rcsb pdb:4R5I|rcsb pdb:4R5J|rcsb pdb:4R5K|rcsb pdb:4R5L|rcsb pdb:5NRO|rcsb pdb:5OOW|rcsb pdb:7JMM|rcsb pdb:7JN8|rcsb pdb:7JN9|rcsb pdb:7JNE|rcsb pdb:7N6J|rcsb pdb:7N6K|rcsb pdb:7N6L|rcsb pdb:7N6M|rcsb pdb:4EZQ|refseq:WP_000516135.1|mint:P0A6Y8|dip:DIP-35751N interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR000353(MHC class II, beta chain, N-terminal) - - no-uniprot-update: figure legend:2A-6|comment:"Inhibitor: HLA-DRB1*0403"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/20 2020/01/09 rogid:jm8ErX3H3EOAYYuSDcddoE/NQx483333 rogid:t0oiEebDmTMAhQ97YLbgIkwvFek9606 rigid:Eyy/O8q8ZDosgTHK+0fGj5nb2+A false - sufficient binding region:94-106|mutation:103-103,100-100 - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation) uniprotkb:P0A6Y8 uniprotkb:P04233 intact:EBI-542092|uniprotkb:P04475|ensemblbacteria:AAC73125|ensemblbacteria:BAB96589 intact:EBI-2622890|uniprotkb:D3DQG3|uniprotkb:D3DQG4|uniprotkb:A8K7R1|uniprotkb:B4DNE8|uniprotkb:Q29832|uniprotkb:Q14597|uniprotkb:Q8SNA0|uniprotkb:Q8WLP6|uniprotkb:Q5U0J8|ensembl:ENSP00000009530 psi-mi:dnak_ecoli(display_long)|uniprotkb:dnaK(gene name)|psi-mi:dnaK(display_short)|uniprotkb:groP(gene name synonym)|uniprotkb:grpF(gene name synonym)|uniprotkb:seg(gene name synonym)|uniprotkb:b0014(locus name)|uniprotkb:Heat shock protein 70(gene name synonym)|uniprotkb:Heat shock 70 kDa protein(gene name synonym)|uniprotkb:HSP70(gene name synonym)|uniprotkb:JW0013(locus name) psi-mi:hg2a_human(display_long)|uniprotkb:DHLAG(gene name synonym)|uniprotkb:HLA-DR antigens-associated invariant chain(gene name synonym)|uniprotkb:Ia antigen-associated invariant chain(gene name synonym)|uniprotkb:CD74(gene name)|psi-mi:CD74(display_short) psi-mi:"MI:0892"(solid phase assay) Haug et al. (2007) imex:IM-25683|pubmed:17357109 taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13952685|imex:IM-25683-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_414555.1|ensemblbacteria:AAC73125(transcript)|ensemblbacteria:b0014(gene)|ensemblbacteria:BAB96589(gene)|ensemblbacteria:BAB96589(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006260"(DNA replication)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009408"(response to heat)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016989"(sigma factor antagonist activity)|go:"GO:0032984"(protein-containing complex disassembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0043531"(ADP binding)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR012725(Chaperone DnaK)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|rcsb pdb:1BPR|rcsb pdb:1DG4|rcsb pdb:1DKG|rcsb pdb:1DKX|rcsb pdb:1DKY|rcsb pdb:1DKZ|rcsb pdb:1Q5L|rcsb pdb:2BPR|rcsb pdb:2KHO|rcsb pdb:3DPO|rcsb pdb:3DPP|rcsb pdb:3DPQ|rcsb pdb:3QNJ|rcsb pdb:4B9Q|rcsb pdb:4E81|rcsb pdb:4EZN|rcsb pdb:4EZO|rcsb pdb:4EZP|rcsb pdb:4EZR|rcsb pdb:4EZS|rcsb pdb:4EZT|rcsb pdb:4EZU|rcsb pdb:4EZV|rcsb pdb:4EZW|rcsb pdb:4EZX|rcsb pdb:4EZY|rcsb pdb:4EZZ|rcsb pdb:4F00|rcsb pdb:4F01|rcsb pdb:4HY9|rcsb pdb:4HYB|rcsb pdb:4JN4|rcsb pdb:4JNE|rcsb pdb:4JNF|rcsb pdb:4JWC|rcsb pdb:4JWD|rcsb pdb:4JWE|rcsb pdb:4JWI|rcsb pdb:4R5G|rcsb pdb:4R5I|rcsb pdb:4R5J|rcsb pdb:4R5K|rcsb pdb:4R5L|rcsb pdb:5NRO|rcsb pdb:5OOW|rcsb pdb:7JMM|rcsb pdb:7JN8|rcsb pdb:7JN9|rcsb pdb:7JNE|rcsb pdb:7N6J|rcsb pdb:7N6K|rcsb pdb:7N6L|rcsb pdb:7N6M|rcsb pdb:4EZQ|refseq:WP_000516135.1|mint:P0A6Y8|dip:DIP-35751N refseq:NP_001020329.1|refseq:NP_001020330.1|refseq:NP_004346.1|ensembl:ENSG00000019582(gene)|ensembl:ENST00000009530(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001961"(positive regulation of cytokine-mediated signaling pathway)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0002606"(positive regulation of dendritic cell antigen processing and presentation)|go:"GO:0002792"(negative regulation of peptide secretion)|go:"GO:0002830"(positive regulation of type 2 immune response)|go:"GO:0002906"(negative regulation of mature B cell apoptotic process)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005773"(vacuole)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019883"(antigen processing and presentation of endogenous antigen)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0019955"(cytokine binding)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031394"(positive regulation of prostaglandin biosynthetic process)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0035691"(macrophage migration inhibitory factor signaling pathway)|go:"GO:0035692"(macrophage migration inhibitory factor receptor complex)|go:"GO:0035693"(NOS2-CD74 complex)|go:"GO:0035718"(macrophage migration inhibitory factor binding)|go:"GO:0042289"(MHC class II protein binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0042658"(MHC class II protein binding, via antigen binding groove)|go:"GO:0042802"(identical protein binding)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045058"(T cell selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045581"(negative regulation of T cell differentiation)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000448"(positive regulation of macrophage migration inhibitory factor signaling pathway)|interpro:IPR000716(Thyroglobulin type-1)|interpro:IPR011988(MHC class II-associated invariant chain, trimerisation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR015386(MHC class II-associated invariant chain/CLIP, MHC II-interacting)|interpro:IPR022339|interpro:IPR036613|go:"GO:0046597"(negative regulation of viral entry into host cell)|interpro:IPR036857|interpro:IPR043530|mint:P04233|rcsb pdb:1A6A|rcsb pdb:1ICF|rcsb pdb:1IIE|rcsb pdb:1L3H|rcsb pdb:1MUJ|rcsb pdb:3PDO|rcsb pdb:3PGC|rcsb pdb:3PGD|go:"GO:0046598"(positive regulation of viral entry into host cell)|rcsb pdb:3QXA|go:"GO:0048146"(positive regulation of fibroblast proliferation)|rcsb pdb:3QXD|rcsb pdb:4AEN|rcsb pdb:4AH2|rcsb pdb:4X5W|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|rcsb pdb:5KSU|rcsb pdb:5KSV|go:"GO:0050821"(protein stabilization)|reactome:R-HSA-202733|reactome:R-HSA-2132295|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070206"(protein trimerization)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade) - - - figure legend:2A-6|comment:"Inhibitor: HLA-DRB1*0403"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/20 2020/01/09 rogid:jm8ErX3H3EOAYYuSDcddoE/NQx483333 rogid:jP1UH09kpXY45O7Qr5OdAfDDIXY9606 rigid:Eyy/O8q8ZDosgTHK+0fGj5nb2+A false - sufficient binding region:105-117|biotin tag:?-? - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation) uniprotkb:P0A6Y8 uniprotkb:P04233 intact:EBI-542092|uniprotkb:P04475|ensemblbacteria:AAC73125|ensemblbacteria:BAB96589 intact:EBI-2622890|uniprotkb:D3DQG3|uniprotkb:D3DQG4|uniprotkb:A8K7R1|uniprotkb:B4DNE8|uniprotkb:Q29832|uniprotkb:Q14597|uniprotkb:Q8SNA0|uniprotkb:Q8WLP6|uniprotkb:Q5U0J8|ensembl:ENSP00000009530 psi-mi:dnak_ecoli(display_long)|uniprotkb:dnaK(gene name)|psi-mi:dnaK(display_short)|uniprotkb:groP(gene name synonym)|uniprotkb:grpF(gene name synonym)|uniprotkb:seg(gene name synonym)|uniprotkb:b0014(locus name)|uniprotkb:Heat shock protein 70(gene name synonym)|uniprotkb:Heat shock 70 kDa protein(gene name synonym)|uniprotkb:HSP70(gene name synonym)|uniprotkb:JW0013(locus name) psi-mi:hg2a_human(display_long)|uniprotkb:DHLAG(gene name synonym)|uniprotkb:HLA-DR antigens-associated invariant chain(gene name synonym)|uniprotkb:Ia antigen-associated invariant chain(gene name synonym)|uniprotkb:CD74(gene name)|psi-mi:CD74(display_short) psi-mi:"MI:0892"(solid phase assay) Haug et al. (2007) imex:IM-25683|pubmed:17357109 taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13952702|imex:IM-25683-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0586"(inhibitor) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_414555.1|ensemblbacteria:AAC73125(transcript)|ensemblbacteria:b0014(gene)|ensemblbacteria:BAB96589(gene)|ensemblbacteria:BAB96589(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006260"(DNA replication)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009408"(response to heat)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016989"(sigma factor antagonist activity)|go:"GO:0032984"(protein-containing complex disassembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0043531"(ADP binding)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR012725(Chaperone DnaK)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|rcsb pdb:1BPR|rcsb pdb:1DG4|rcsb pdb:1DKG|rcsb pdb:1DKX|rcsb pdb:1DKY|rcsb pdb:1DKZ|rcsb pdb:1Q5L|rcsb pdb:2BPR|rcsb pdb:2KHO|rcsb pdb:3DPO|rcsb pdb:3DPP|rcsb pdb:3DPQ|rcsb pdb:3QNJ|rcsb pdb:4B9Q|rcsb pdb:4E81|rcsb pdb:4EZN|rcsb pdb:4EZO|rcsb pdb:4EZP|rcsb pdb:4EZR|rcsb pdb:4EZS|rcsb pdb:4EZT|rcsb pdb:4EZU|rcsb pdb:4EZV|rcsb pdb:4EZW|rcsb pdb:4EZX|rcsb pdb:4EZY|rcsb pdb:4EZZ|rcsb pdb:4F00|rcsb pdb:4F01|rcsb pdb:4HY9|rcsb pdb:4HYB|rcsb pdb:4JN4|rcsb pdb:4JNE|rcsb pdb:4JNF|rcsb pdb:4JWC|rcsb pdb:4JWD|rcsb pdb:4JWE|rcsb pdb:4JWI|rcsb pdb:4R5G|rcsb pdb:4R5I|rcsb pdb:4R5J|rcsb pdb:4R5K|rcsb pdb:4R5L|rcsb pdb:5NRO|rcsb pdb:5OOW|rcsb pdb:7JMM|rcsb pdb:7JN8|rcsb pdb:7JN9|rcsb pdb:7JNE|rcsb pdb:7N6J|rcsb pdb:7N6K|rcsb pdb:7N6L|rcsb pdb:7N6M|rcsb pdb:4EZQ|refseq:WP_000516135.1|mint:P0A6Y8|dip:DIP-35751N refseq:NP_001020329.1|refseq:NP_001020330.1|refseq:NP_004346.1|ensembl:ENSG00000019582(gene)|ensembl:ENST00000009530(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001961"(positive regulation of cytokine-mediated signaling pathway)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0002606"(positive regulation of dendritic cell antigen processing and presentation)|go:"GO:0002792"(negative regulation of peptide secretion)|go:"GO:0002830"(positive regulation of type 2 immune response)|go:"GO:0002906"(negative regulation of mature B cell apoptotic process)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005773"(vacuole)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019883"(antigen processing and presentation of endogenous antigen)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0019955"(cytokine binding)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031394"(positive regulation of prostaglandin biosynthetic process)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0035691"(macrophage migration inhibitory factor signaling pathway)|go:"GO:0035692"(macrophage migration inhibitory factor receptor complex)|go:"GO:0035693"(NOS2-CD74 complex)|go:"GO:0035718"(macrophage migration inhibitory factor binding)|go:"GO:0042289"(MHC class II protein binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0042658"(MHC class II protein binding, via antigen binding groove)|go:"GO:0042802"(identical protein binding)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045058"(T cell selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045581"(negative regulation of T cell differentiation)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000448"(positive regulation of macrophage migration inhibitory factor signaling pathway)|interpro:IPR000716(Thyroglobulin type-1)|interpro:IPR011988(MHC class II-associated invariant chain, trimerisation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR015386(MHC class II-associated invariant chain/CLIP, MHC II-interacting)|interpro:IPR022339|interpro:IPR036613|go:"GO:0046597"(negative regulation of viral entry into host cell)|interpro:IPR036857|interpro:IPR043530|mint:P04233|rcsb pdb:1A6A|rcsb pdb:1ICF|rcsb pdb:1IIE|rcsb pdb:1L3H|rcsb pdb:1MUJ|rcsb pdb:3PDO|rcsb pdb:3PGC|rcsb pdb:3PGD|go:"GO:0046598"(positive regulation of viral entry into host cell)|rcsb pdb:3QXA|go:"GO:0048146"(positive regulation of fibroblast proliferation)|rcsb pdb:3QXD|rcsb pdb:4AEN|rcsb pdb:4AH2|rcsb pdb:4X5W|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|rcsb pdb:5KSU|rcsb pdb:5KSV|go:"GO:0050821"(protein stabilization)|reactome:R-HSA-202733|reactome:R-HSA-2132295|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070206"(protein trimerization)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade) - - - figure legend:2A-8|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/20 2017/04/11 rogid:jm8ErX3H3EOAYYuSDcddoE/NQx483333 rogid:jP1UH09kpXY45O7Qr5OdAfDDIXY9606 rigid:CDgHJV5M4P1skZFsvqD7JQLV6fk false - sufficient binding region:105-117 - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation) uniprotkb:P0A6Y8 uniprotkb:P04233 intact:EBI-542092|uniprotkb:P04475|ensemblbacteria:AAC73125|ensemblbacteria:BAB96589 intact:EBI-2622890|uniprotkb:D3DQG3|uniprotkb:D3DQG4|uniprotkb:A8K7R1|uniprotkb:B4DNE8|uniprotkb:Q29832|uniprotkb:Q14597|uniprotkb:Q8SNA0|uniprotkb:Q8WLP6|uniprotkb:Q5U0J8|ensembl:ENSP00000009530 psi-mi:dnak_ecoli(display_long)|uniprotkb:dnaK(gene name)|psi-mi:dnaK(display_short)|uniprotkb:groP(gene name synonym)|uniprotkb:grpF(gene name synonym)|uniprotkb:seg(gene name synonym)|uniprotkb:b0014(locus name)|uniprotkb:Heat shock protein 70(gene name synonym)|uniprotkb:Heat shock 70 kDa protein(gene name synonym)|uniprotkb:HSP70(gene name synonym)|uniprotkb:JW0013(locus name) psi-mi:hg2a_human(display_long)|uniprotkb:DHLAG(gene name synonym)|uniprotkb:HLA-DR antigens-associated invariant chain(gene name synonym)|uniprotkb:Ia antigen-associated invariant chain(gene name synonym)|uniprotkb:CD74(gene name)|psi-mi:CD74(display_short) psi-mi:"MI:0892"(solid phase assay) Haug et al. (2007) imex:IM-25683|pubmed:17357109 taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13952702|imex:IM-25683-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_414555.1|ensemblbacteria:AAC73125(transcript)|ensemblbacteria:b0014(gene)|ensemblbacteria:BAB96589(gene)|ensemblbacteria:BAB96589(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006260"(DNA replication)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009408"(response to heat)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016989"(sigma factor antagonist activity)|go:"GO:0032984"(protein-containing complex disassembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0043531"(ADP binding)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR012725(Chaperone DnaK)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|rcsb pdb:1BPR|rcsb pdb:1DG4|rcsb pdb:1DKG|rcsb pdb:1DKX|rcsb pdb:1DKY|rcsb pdb:1DKZ|rcsb pdb:1Q5L|rcsb pdb:2BPR|rcsb pdb:2KHO|rcsb pdb:3DPO|rcsb pdb:3DPP|rcsb pdb:3DPQ|rcsb pdb:3QNJ|rcsb pdb:4B9Q|rcsb pdb:4E81|rcsb pdb:4EZN|rcsb pdb:4EZO|rcsb pdb:4EZP|rcsb pdb:4EZR|rcsb pdb:4EZS|rcsb pdb:4EZT|rcsb pdb:4EZU|rcsb pdb:4EZV|rcsb pdb:4EZW|rcsb pdb:4EZX|rcsb pdb:4EZY|rcsb pdb:4EZZ|rcsb pdb:4F00|rcsb pdb:4F01|rcsb pdb:4HY9|rcsb pdb:4HYB|rcsb pdb:4JN4|rcsb pdb:4JNE|rcsb pdb:4JNF|rcsb pdb:4JWC|rcsb pdb:4JWD|rcsb pdb:4JWE|rcsb pdb:4JWI|rcsb pdb:4R5G|rcsb pdb:4R5I|rcsb pdb:4R5J|rcsb pdb:4R5K|rcsb pdb:4R5L|rcsb pdb:5NRO|rcsb pdb:5OOW|rcsb pdb:7JMM|rcsb pdb:7JN8|rcsb pdb:7JN9|rcsb pdb:7JNE|rcsb pdb:7N6J|rcsb pdb:7N6K|rcsb pdb:7N6L|rcsb pdb:7N6M|rcsb pdb:4EZQ|refseq:WP_000516135.1|mint:P0A6Y8|dip:DIP-35751N refseq:NP_001020329.1|refseq:NP_001020330.1|refseq:NP_004346.1|ensembl:ENSG00000019582(gene)|ensembl:ENST00000009530(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001961"(positive regulation of cytokine-mediated signaling pathway)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0002606"(positive regulation of dendritic cell antigen processing and presentation)|go:"GO:0002792"(negative regulation of peptide secretion)|go:"GO:0002830"(positive regulation of type 2 immune response)|go:"GO:0002906"(negative regulation of mature B cell apoptotic process)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005773"(vacuole)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019883"(antigen processing and presentation of endogenous antigen)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0019955"(cytokine binding)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031394"(positive regulation of prostaglandin biosynthetic process)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0035691"(macrophage migration inhibitory factor signaling pathway)|go:"GO:0035692"(macrophage migration inhibitory factor receptor complex)|go:"GO:0035693"(NOS2-CD74 complex)|go:"GO:0035718"(macrophage migration inhibitory factor binding)|go:"GO:0042289"(MHC class II protein binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0042658"(MHC class II protein binding, via antigen binding groove)|go:"GO:0042802"(identical protein binding)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045058"(T cell selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045581"(negative regulation of T cell differentiation)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000448"(positive regulation of macrophage migration inhibitory factor signaling pathway)|interpro:IPR000716(Thyroglobulin type-1)|interpro:IPR011988(MHC class II-associated invariant chain, trimerisation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR015386(MHC class II-associated invariant chain/CLIP, MHC II-interacting)|interpro:IPR022339|interpro:IPR036613|go:"GO:0046597"(negative regulation of viral entry into host cell)|interpro:IPR036857|interpro:IPR043530|mint:P04233|rcsb pdb:1A6A|rcsb pdb:1ICF|rcsb pdb:1IIE|rcsb pdb:1L3H|rcsb pdb:1MUJ|rcsb pdb:3PDO|rcsb pdb:3PGC|rcsb pdb:3PGD|go:"GO:0046598"(positive regulation of viral entry into host cell)|rcsb pdb:3QXA|go:"GO:0048146"(positive regulation of fibroblast proliferation)|rcsb pdb:3QXD|rcsb pdb:4AEN|rcsb pdb:4AH2|rcsb pdb:4X5W|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|rcsb pdb:5KSU|rcsb pdb:5KSV|go:"GO:0050821"(protein stabilization)|reactome:R-HSA-202733|reactome:R-HSA-2132295|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070206"(protein trimerization)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade) - - - figure legend:2A-8|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/20 2017/04/11 rogid:jm8ErX3H3EOAYYuSDcddoE/NQx483333 rogid:jP1UH09kpXY45O7Qr5OdAfDDIXY9606 rigid:CDgHJV5M4P1skZFsvqD7JQLV6fk false - sufficient binding region:105-117|biotin tag:?-? - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation) uniprotkb:P0A6Y8 uniprotkb:P04958 intact:EBI-542092|uniprotkb:P04475|ensemblbacteria:AAC73125|ensemblbacteria:BAB96589 intact:EBI-13951617|ensemblbacteria:AAO37454 psi-mi:dnak_ecoli(display_long)|uniprotkb:dnaK(gene name)|psi-mi:dnaK(display_short)|uniprotkb:groP(gene name synonym)|uniprotkb:grpF(gene name synonym)|uniprotkb:seg(gene name synonym)|uniprotkb:b0014(locus name)|uniprotkb:Heat shock protein 70(gene name synonym)|uniprotkb:Heat shock 70 kDa protein(gene name synonym)|uniprotkb:HSP70(gene name synonym)|uniprotkb:JW0013(locus name) psi-mi:tetx_clote(display_long)|uniprotkb:tetX(gene name)|psi-mi:tetX(display_short)|uniprotkb:Tentoxylysin(gene name synonym)|uniprotkb:CTC_p60(locus name) psi-mi:"MI:0892"(solid phase assay) Haug et al. (2007) imex:IM-25683|pubmed:17357109 taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") taxid:212717("Clostridium tetani (strain Massachusetts / E88)")|taxid:212717("Clostridium tetani (strain Massachusetts / E88)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13952714|imex:IM-25683-14 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0586"(inhibitor) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_414555.1|ensemblbacteria:AAC73125(transcript)|ensemblbacteria:b0014(gene)|ensemblbacteria:BAB96589(gene)|ensemblbacteria:BAB96589(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006260"(DNA replication)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009408"(response to heat)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016989"(sigma factor antagonist activity)|go:"GO:0032984"(protein-containing complex disassembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0043531"(ADP binding)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR012725(Chaperone DnaK)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|rcsb pdb:1BPR|rcsb pdb:1DG4|rcsb pdb:1DKG|rcsb pdb:1DKX|rcsb pdb:1DKY|rcsb pdb:1DKZ|rcsb pdb:1Q5L|rcsb pdb:2BPR|rcsb pdb:2KHO|rcsb pdb:3DPO|rcsb pdb:3DPP|rcsb pdb:3DPQ|rcsb pdb:3QNJ|rcsb pdb:4B9Q|rcsb pdb:4E81|rcsb pdb:4EZN|rcsb pdb:4EZO|rcsb pdb:4EZP|rcsb pdb:4EZR|rcsb pdb:4EZS|rcsb pdb:4EZT|rcsb pdb:4EZU|rcsb pdb:4EZV|rcsb pdb:4EZW|rcsb pdb:4EZX|rcsb pdb:4EZY|rcsb pdb:4EZZ|rcsb pdb:4F00|rcsb pdb:4F01|rcsb pdb:4HY9|rcsb pdb:4HYB|rcsb pdb:4JN4|rcsb pdb:4JNE|rcsb pdb:4JNF|rcsb pdb:4JWC|rcsb pdb:4JWD|rcsb pdb:4JWE|rcsb pdb:4JWI|rcsb pdb:4R5G|rcsb pdb:4R5I|rcsb pdb:4R5J|rcsb pdb:4R5K|rcsb pdb:4R5L|rcsb pdb:5NRO|rcsb pdb:5OOW|rcsb pdb:7JMM|rcsb pdb:7JN8|rcsb pdb:7JN9|rcsb pdb:7JNE|rcsb pdb:7N6J|rcsb pdb:7N6K|rcsb pdb:7N6L|rcsb pdb:7N6M|rcsb pdb:4EZQ|refseq:WP_000516135.1|mint:P0A6Y8|dip:DIP-35751N go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0046929"(negative regulation of neurotransmitter secretion)|go:"GO:0090729"(toxin activity)|ensemblbacteria:AAO37454(transcript)|ensemblbacteria:CTC_p60(gene)|go:"GO:0004222"(metalloendopeptidase activity)|refseq:WP_011100836.1|rcsb pdb:1A8D|rcsb pdb:1AF9|rcsb pdb:1D0H|rcsb pdb:1DFQ|rcsb pdb:1DIW|rcsb pdb:1DLL|rcsb pdb:1FV2|rcsb pdb:1FV3|rcsb pdb:1YVG|rcsb pdb:1YXW|rcsb pdb:1YYN|rcsb pdb:1Z7H|rcsb pdb:3HMY|rcsb pdb:3HN1|rcsb pdb:4J1L|reactome:R-HSA-5250982|interpro:IPR000395(Peptidase M27, bontoxilysin)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR011065(Kunitz inhibitor ST1-like)|interpro:IPR013104(Clostridium neurotoxin, receptor-binding C-terminal)|interpro:IPR012928(Clostridium neurotoxin, receptor binding N-terminal)|interpro:IPR012500(Clostridium neurotoxin, translocation)|rcsb pdb:5N0B|rcsb pdb:5N0C|interpro:IPR036248|rcsb pdb:7BXX|rcsb pdb:7BY4|rcsb pdb:7BY5 - - - figure legend:2A-9|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/20 2017/04/11 rogid:jm8ErX3H3EOAYYuSDcddoE/NQx483333 rogid:arI9eRMHUPPu5ZWeO5ET1JoJKB0212717 rigid:5ivsGaUrJ00NOCNPCHGgg39rbr4 false - sufficient binding region:1187-1206 - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation) uniprotkb:P0A6Y8 uniprotkb:P04233 intact:EBI-542092|uniprotkb:P04475|ensemblbacteria:AAC73125|ensemblbacteria:BAB96589 intact:EBI-2622890|uniprotkb:D3DQG3|uniprotkb:D3DQG4|uniprotkb:A8K7R1|uniprotkb:B4DNE8|uniprotkb:Q29832|uniprotkb:Q14597|uniprotkb:Q8SNA0|uniprotkb:Q8WLP6|uniprotkb:Q5U0J8|ensembl:ENSP00000009530 psi-mi:dnak_ecoli(display_long)|uniprotkb:dnaK(gene name)|psi-mi:dnaK(display_short)|uniprotkb:groP(gene name synonym)|uniprotkb:grpF(gene name synonym)|uniprotkb:seg(gene name synonym)|uniprotkb:b0014(locus name)|uniprotkb:Heat shock protein 70(gene name synonym)|uniprotkb:Heat shock 70 kDa protein(gene name synonym)|uniprotkb:HSP70(gene name synonym)|uniprotkb:JW0013(locus name) psi-mi:hg2a_human(display_long)|uniprotkb:DHLAG(gene name synonym)|uniprotkb:HLA-DR antigens-associated invariant chain(gene name synonym)|uniprotkb:Ia antigen-associated invariant chain(gene name synonym)|uniprotkb:CD74(gene name)|psi-mi:CD74(display_short) psi-mi:"MI:0892"(solid phase assay) Haug et al. (2007) imex:IM-25683|pubmed:17357109 taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13952714|imex:IM-25683-14 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_414555.1|ensemblbacteria:AAC73125(transcript)|ensemblbacteria:b0014(gene)|ensemblbacteria:BAB96589(gene)|ensemblbacteria:BAB96589(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006260"(DNA replication)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009408"(response to heat)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016989"(sigma factor antagonist activity)|go:"GO:0032984"(protein-containing complex disassembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0043531"(ADP binding)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR012725(Chaperone DnaK)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|rcsb pdb:1BPR|rcsb pdb:1DG4|rcsb pdb:1DKG|rcsb pdb:1DKX|rcsb pdb:1DKY|rcsb pdb:1DKZ|rcsb pdb:1Q5L|rcsb pdb:2BPR|rcsb pdb:2KHO|rcsb pdb:3DPO|rcsb pdb:3DPP|rcsb pdb:3DPQ|rcsb pdb:3QNJ|rcsb pdb:4B9Q|rcsb pdb:4E81|rcsb pdb:4EZN|rcsb pdb:4EZO|rcsb pdb:4EZP|rcsb pdb:4EZR|rcsb pdb:4EZS|rcsb pdb:4EZT|rcsb pdb:4EZU|rcsb pdb:4EZV|rcsb pdb:4EZW|rcsb pdb:4EZX|rcsb pdb:4EZY|rcsb pdb:4EZZ|rcsb pdb:4F00|rcsb pdb:4F01|rcsb pdb:4HY9|rcsb pdb:4HYB|rcsb pdb:4JN4|rcsb pdb:4JNE|rcsb pdb:4JNF|rcsb pdb:4JWC|rcsb pdb:4JWD|rcsb pdb:4JWE|rcsb pdb:4JWI|rcsb pdb:4R5G|rcsb pdb:4R5I|rcsb pdb:4R5J|rcsb pdb:4R5K|rcsb pdb:4R5L|rcsb pdb:5NRO|rcsb pdb:5OOW|rcsb pdb:7JMM|rcsb pdb:7JN8|rcsb pdb:7JN9|rcsb pdb:7JNE|rcsb pdb:7N6J|rcsb pdb:7N6K|rcsb pdb:7N6L|rcsb pdb:7N6M|rcsb pdb:4EZQ|refseq:WP_000516135.1|mint:P0A6Y8|dip:DIP-35751N refseq:NP_001020329.1|refseq:NP_001020330.1|refseq:NP_004346.1|ensembl:ENSG00000019582(gene)|ensembl:ENST00000009530(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001961"(positive regulation of cytokine-mediated signaling pathway)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0002606"(positive regulation of dendritic cell antigen processing and presentation)|go:"GO:0002792"(negative regulation of peptide secretion)|go:"GO:0002830"(positive regulation of type 2 immune response)|go:"GO:0002906"(negative regulation of mature B cell apoptotic process)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005773"(vacuole)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019883"(antigen processing and presentation of endogenous antigen)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0019955"(cytokine binding)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031394"(positive regulation of prostaglandin biosynthetic process)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0035691"(macrophage migration inhibitory factor signaling pathway)|go:"GO:0035692"(macrophage migration inhibitory factor receptor complex)|go:"GO:0035693"(NOS2-CD74 complex)|go:"GO:0035718"(macrophage migration inhibitory factor binding)|go:"GO:0042289"(MHC class II protein binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0042658"(MHC class II protein binding, via antigen binding groove)|go:"GO:0042802"(identical protein binding)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045058"(T cell selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045581"(negative regulation of T cell differentiation)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000448"(positive regulation of macrophage migration inhibitory factor signaling pathway)|interpro:IPR000716(Thyroglobulin type-1)|interpro:IPR011988(MHC class II-associated invariant chain, trimerisation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR015386(MHC class II-associated invariant chain/CLIP, MHC II-interacting)|interpro:IPR022339|interpro:IPR036613|go:"GO:0046597"(negative regulation of viral entry into host cell)|interpro:IPR036857|interpro:IPR043530|mint:P04233|rcsb pdb:1A6A|rcsb pdb:1ICF|rcsb pdb:1IIE|rcsb pdb:1L3H|rcsb pdb:1MUJ|rcsb pdb:3PDO|rcsb pdb:3PGC|rcsb pdb:3PGD|go:"GO:0046598"(positive regulation of viral entry into host cell)|rcsb pdb:3QXA|go:"GO:0048146"(positive regulation of fibroblast proliferation)|rcsb pdb:3QXD|rcsb pdb:4AEN|rcsb pdb:4AH2|rcsb pdb:4X5W|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|rcsb pdb:5KSU|rcsb pdb:5KSV|go:"GO:0050821"(protein stabilization)|reactome:R-HSA-202733|reactome:R-HSA-2132295|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070206"(protein trimerization)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade) - - - figure legend:2A-9|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/20 2017/04/11 rogid:jm8ErX3H3EOAYYuSDcddoE/NQx483333 rogid:jP1UH09kpXY45O7Qr5OdAfDDIXY9606 rigid:5ivsGaUrJ00NOCNPCHGgg39rbr4 false - sufficient binding region:105-117|biotin tag:?-? - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation) uniprotkb:P04233 intact:EBI-11820565 intact:EBI-2622890|uniprotkb:D3DQG3|uniprotkb:D3DQG4|uniprotkb:A8K7R1|uniprotkb:B4DNE8|uniprotkb:Q29832|uniprotkb:Q14597|uniprotkb:Q8SNA0|uniprotkb:Q8WLP6|uniprotkb:Q5U0J8|ensembl:ENSP00000009530 - psi-mi:hg2a_human(display_long)|uniprotkb:DHLAG(gene name synonym)|uniprotkb:HLA-DR antigens-associated invariant chain(gene name synonym)|uniprotkb:Ia antigen-associated invariant chain(gene name synonym)|uniprotkb:CD74(gene name)|psi-mi:CD74(display_short) psi-mi:hspa1a_hspa1b_human-1(display_short)|psi-mi:EBI-11820565(display_long) psi-mi:"MI:0892"(solid phase assay) Haug et al. (2007) imex:IM-25683|pubmed:17357109 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-13952729|imex:IM-25683-15 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:1304"(molecule set) refseq:NP_001020329.1|refseq:NP_001020330.1|refseq:NP_004346.1|ensembl:ENSG00000019582(gene)|ensembl:ENST00000009530(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001961"(positive regulation of cytokine-mediated signaling pathway)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0002606"(positive regulation of dendritic cell antigen processing and presentation)|go:"GO:0002792"(negative regulation of peptide secretion)|go:"GO:0002830"(positive regulation of type 2 immune response)|go:"GO:0002906"(negative regulation of mature B cell apoptotic process)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005773"(vacuole)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019883"(antigen processing and presentation of endogenous antigen)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0019955"(cytokine binding)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031394"(positive regulation of prostaglandin biosynthetic process)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0035691"(macrophage migration inhibitory factor signaling pathway)|go:"GO:0035692"(macrophage migration inhibitory factor receptor complex)|go:"GO:0035693"(NOS2-CD74 complex)|go:"GO:0035718"(macrophage migration inhibitory factor binding)|go:"GO:0042289"(MHC class II protein binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0042658"(MHC class II protein binding, via antigen binding groove)|go:"GO:0042802"(identical protein binding)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045058"(T cell selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045581"(negative regulation of T cell differentiation)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000448"(positive regulation of macrophage migration inhibitory factor signaling pathway)|interpro:IPR000716(Thyroglobulin type-1)|interpro:IPR011988(MHC class II-associated invariant chain, trimerisation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR015386(MHC class II-associated invariant chain/CLIP, MHC II-interacting)|interpro:IPR022339|interpro:IPR036613|go:"GO:0046597"(negative regulation of viral entry into host cell)|interpro:IPR036857|interpro:IPR043530|mint:P04233|rcsb pdb:1A6A|rcsb pdb:1ICF|rcsb pdb:1IIE|rcsb pdb:1L3H|rcsb pdb:1MUJ|rcsb pdb:3PDO|rcsb pdb:3PGC|rcsb pdb:3PGD|go:"GO:0046598"(positive regulation of viral entry into host cell)|rcsb pdb:3QXA|go:"GO:0048146"(positive regulation of fibroblast proliferation)|rcsb pdb:3QXD|rcsb pdb:4AEN|rcsb pdb:4AH2|rcsb pdb:4X5W|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|rcsb pdb:5KSU|rcsb pdb:5KSV|go:"GO:0050821"(protein stabilization)|reactome:R-HSA-202733|reactome:R-HSA-2132295|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070206"(protein trimerization)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade) - - - comment:P0DMV8,P0DMV9 figure legend:2B, 7A|comment:Unlabeled HLA-DR-derived peptide fragments showed very weak competition|antagonist:ATP|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/20 2020/10/15 rogid:jP1UH09kpXY45O7Qr5OdAfDDIXY9606 - - false sufficient binding region:105-117|biotin tag:?-? - - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation) intact:EBI-11820565 uniprotkb:P04233 - intact:EBI-2622890|uniprotkb:D3DQG3|uniprotkb:D3DQG4|uniprotkb:A8K7R1|uniprotkb:B4DNE8|uniprotkb:Q29832|uniprotkb:Q14597|uniprotkb:Q8SNA0|uniprotkb:Q8WLP6|uniprotkb:Q5U0J8|ensembl:ENSP00000009530 psi-mi:hspa1a_hspa1b_human-1(display_short)|psi-mi:EBI-11820565(display_long) psi-mi:hg2a_human(display_long)|uniprotkb:DHLAG(gene name synonym)|uniprotkb:HLA-DR antigens-associated invariant chain(gene name synonym)|uniprotkb:Ia antigen-associated invariant chain(gene name synonym)|uniprotkb:CD74(gene name)|psi-mi:CD74(display_short) psi-mi:"MI:0892"(solid phase assay) Haug et al. (2007) imex:IM-25683|pubmed:17357109 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13952739|imex:IM-25683-16 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0586"(inhibitor) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:1304"(molecule set) psi-mi:"MI:0326"(protein) - refseq:NP_001020329.1|refseq:NP_001020330.1|refseq:NP_004346.1|ensembl:ENSG00000019582(gene)|ensembl:ENST00000009530(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001961"(positive regulation of cytokine-mediated signaling pathway)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0002606"(positive regulation of dendritic cell antigen processing and presentation)|go:"GO:0002792"(negative regulation of peptide secretion)|go:"GO:0002830"(positive regulation of type 2 immune response)|go:"GO:0002906"(negative regulation of mature B cell apoptotic process)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005773"(vacuole)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019883"(antigen processing and presentation of endogenous antigen)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0019955"(cytokine binding)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031394"(positive regulation of prostaglandin biosynthetic process)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0035691"(macrophage migration inhibitory factor signaling pathway)|go:"GO:0035692"(macrophage migration inhibitory factor receptor complex)|go:"GO:0035693"(NOS2-CD74 complex)|go:"GO:0035718"(macrophage migration inhibitory factor binding)|go:"GO:0042289"(MHC class II protein binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0042658"(MHC class II protein binding, via antigen binding groove)|go:"GO:0042802"(identical protein binding)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045058"(T cell selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045581"(negative regulation of T cell differentiation)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000448"(positive regulation of macrophage migration inhibitory factor signaling pathway)|interpro:IPR000716(Thyroglobulin type-1)|interpro:IPR011988(MHC class II-associated invariant chain, trimerisation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR015386(MHC class II-associated invariant chain/CLIP, MHC II-interacting)|interpro:IPR022339|interpro:IPR036613|go:"GO:0046597"(negative regulation of viral entry into host cell)|interpro:IPR036857|interpro:IPR043530|mint:P04233|rcsb pdb:1A6A|rcsb pdb:1ICF|rcsb pdb:1IIE|rcsb pdb:1L3H|rcsb pdb:1MUJ|rcsb pdb:3PDO|rcsb pdb:3PGC|rcsb pdb:3PGD|go:"GO:0046598"(positive regulation of viral entry into host cell)|rcsb pdb:3QXA|go:"GO:0048146"(positive regulation of fibroblast proliferation)|rcsb pdb:3QXD|rcsb pdb:4AEN|rcsb pdb:4AH2|rcsb pdb:4X5W|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|rcsb pdb:5KSU|rcsb pdb:5KSV|go:"GO:0050821"(protein stabilization)|reactome:R-HSA-202733|reactome:R-HSA-2132295|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070206"(protein trimerization)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade) - comment:P0DMV8,P0DMV9 - figure legend:2Bi|comment:"Unlabeled CLIP peptide as well as a peptide from tetanus toxin (TT 947–966) showed stronger competition as compared to the HLA-DR-derived peptide fragments."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/20 2020/10/15 - rogid:jP1UH09kpXY45O7Qr5OdAfDDIXY9606 - false - sufficient binding region:105-117 - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation) intact:EBI-11820565 uniprotkb:P04233 - intact:EBI-2622890|uniprotkb:D3DQG3|uniprotkb:D3DQG4|uniprotkb:A8K7R1|uniprotkb:B4DNE8|uniprotkb:Q29832|uniprotkb:Q14597|uniprotkb:Q8SNA0|uniprotkb:Q8WLP6|uniprotkb:Q5U0J8|ensembl:ENSP00000009530 psi-mi:hspa1a_hspa1b_human-1(display_short)|psi-mi:EBI-11820565(display_long) psi-mi:hg2a_human(display_long)|uniprotkb:DHLAG(gene name synonym)|uniprotkb:HLA-DR antigens-associated invariant chain(gene name synonym)|uniprotkb:Ia antigen-associated invariant chain(gene name synonym)|uniprotkb:CD74(gene name)|psi-mi:CD74(display_short) psi-mi:"MI:0892"(solid phase assay) Haug et al. (2007) imex:IM-25683|pubmed:17357109 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13952739|imex:IM-25683-16 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:1304"(molecule set) psi-mi:"MI:0326"(protein) - refseq:NP_001020329.1|refseq:NP_001020330.1|refseq:NP_004346.1|ensembl:ENSG00000019582(gene)|ensembl:ENST00000009530(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001961"(positive regulation of cytokine-mediated signaling pathway)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0002606"(positive regulation of dendritic cell antigen processing and presentation)|go:"GO:0002792"(negative regulation of peptide secretion)|go:"GO:0002830"(positive regulation of type 2 immune response)|go:"GO:0002906"(negative regulation of mature B cell apoptotic process)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005773"(vacuole)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019883"(antigen processing and presentation of endogenous antigen)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0019955"(cytokine binding)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031394"(positive regulation of prostaglandin biosynthetic process)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0035691"(macrophage migration inhibitory factor signaling pathway)|go:"GO:0035692"(macrophage migration inhibitory factor receptor complex)|go:"GO:0035693"(NOS2-CD74 complex)|go:"GO:0035718"(macrophage migration inhibitory factor binding)|go:"GO:0042289"(MHC class II protein binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0042658"(MHC class II protein binding, via antigen binding groove)|go:"GO:0042802"(identical protein binding)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045058"(T cell selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045581"(negative regulation of T cell differentiation)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000448"(positive regulation of macrophage migration inhibitory factor signaling pathway)|interpro:IPR000716(Thyroglobulin type-1)|interpro:IPR011988(MHC class II-associated invariant chain, trimerisation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR015386(MHC class II-associated invariant chain/CLIP, MHC II-interacting)|interpro:IPR022339|interpro:IPR036613|go:"GO:0046597"(negative regulation of viral entry into host cell)|interpro:IPR036857|interpro:IPR043530|mint:P04233|rcsb pdb:1A6A|rcsb pdb:1ICF|rcsb pdb:1IIE|rcsb pdb:1L3H|rcsb pdb:1MUJ|rcsb pdb:3PDO|rcsb pdb:3PGC|rcsb pdb:3PGD|go:"GO:0046598"(positive regulation of viral entry into host cell)|rcsb pdb:3QXA|go:"GO:0048146"(positive regulation of fibroblast proliferation)|rcsb pdb:3QXD|rcsb pdb:4AEN|rcsb pdb:4AH2|rcsb pdb:4X5W|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|rcsb pdb:5KSU|rcsb pdb:5KSV|go:"GO:0050821"(protein stabilization)|reactome:R-HSA-202733|reactome:R-HSA-2132295|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070206"(protein trimerization)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade) - comment:P0DMV8,P0DMV9 - figure legend:2Bi|comment:"Unlabeled CLIP peptide as well as a peptide from tetanus toxin (TT 947–966) showed stronger competition as compared to the HLA-DR-derived peptide fragments."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/20 2020/10/15 - rogid:jP1UH09kpXY45O7Qr5OdAfDDIXY9606 - false - sufficient binding region:105-117|biotin tag:?-? - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation) intact:EBI-11820565 uniprotkb:P04958 - intact:EBI-13951617|ensemblbacteria:AAO37454 psi-mi:hspa1a_hspa1b_human-1(display_short)|psi-mi:EBI-11820565(display_long) psi-mi:tetx_clote(display_long)|uniprotkb:tetX(gene name)|psi-mi:tetX(display_short)|uniprotkb:Tentoxylysin(gene name synonym)|uniprotkb:CTC_p60(locus name) psi-mi:"MI:0892"(solid phase assay) Haug et al. (2007) imex:IM-25683|pubmed:17357109 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:212717("Clostridium tetani (strain Massachusetts / E88)")|taxid:212717("Clostridium tetani (strain Massachusetts / E88)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13952752|imex:IM-25683-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0586"(inhibitor) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:1304"(molecule set) psi-mi:"MI:0326"(protein) - go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0046929"(negative regulation of neurotransmitter secretion)|go:"GO:0090729"(toxin activity)|ensemblbacteria:AAO37454(transcript)|ensemblbacteria:CTC_p60(gene)|go:"GO:0004222"(metalloendopeptidase activity)|refseq:WP_011100836.1|rcsb pdb:1A8D|rcsb pdb:1AF9|rcsb pdb:1D0H|rcsb pdb:1DFQ|rcsb pdb:1DIW|rcsb pdb:1DLL|rcsb pdb:1FV2|rcsb pdb:1FV3|rcsb pdb:1YVG|rcsb pdb:1YXW|rcsb pdb:1YYN|rcsb pdb:1Z7H|rcsb pdb:3HMY|rcsb pdb:3HN1|rcsb pdb:4J1L|reactome:R-HSA-5250982|interpro:IPR000395(Peptidase M27, bontoxilysin)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR011065(Kunitz inhibitor ST1-like)|interpro:IPR013104(Clostridium neurotoxin, receptor-binding C-terminal)|interpro:IPR012928(Clostridium neurotoxin, receptor binding N-terminal)|interpro:IPR012500(Clostridium neurotoxin, translocation)|rcsb pdb:5N0B|rcsb pdb:5N0C|interpro:IPR036248|rcsb pdb:7BXX|rcsb pdb:7BY4|rcsb pdb:7BY5 - comment:P0DMV8,P0DMV9 - figure legend:2Bii|comment:"Unlabeled CLIP peptide as well as a peptide from tetanus toxin (TT 947–966) showed stronger competition as compared to the HLA-DR-derived peptide fragments."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/20 2020/10/15 - rogid:arI9eRMHUPPu5ZWeO5ET1JoJKB0212717 - false - sufficient binding region:947-966 - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation) intact:EBI-11820565 uniprotkb:P04233 - intact:EBI-2622890|uniprotkb:D3DQG3|uniprotkb:D3DQG4|uniprotkb:A8K7R1|uniprotkb:B4DNE8|uniprotkb:Q29832|uniprotkb:Q14597|uniprotkb:Q8SNA0|uniprotkb:Q8WLP6|uniprotkb:Q5U0J8|ensembl:ENSP00000009530 psi-mi:hspa1a_hspa1b_human-1(display_short)|psi-mi:EBI-11820565(display_long) psi-mi:hg2a_human(display_long)|uniprotkb:DHLAG(gene name synonym)|uniprotkb:HLA-DR antigens-associated invariant chain(gene name synonym)|uniprotkb:Ia antigen-associated invariant chain(gene name synonym)|uniprotkb:CD74(gene name)|psi-mi:CD74(display_short) psi-mi:"MI:0892"(solid phase assay) Haug et al. (2007) imex:IM-25683|pubmed:17357109 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13952752|imex:IM-25683-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:1304"(molecule set) psi-mi:"MI:0326"(protein) - refseq:NP_001020329.1|refseq:NP_001020330.1|refseq:NP_004346.1|ensembl:ENSG00000019582(gene)|ensembl:ENST00000009530(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001961"(positive regulation of cytokine-mediated signaling pathway)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0002606"(positive regulation of dendritic cell antigen processing and presentation)|go:"GO:0002792"(negative regulation of peptide secretion)|go:"GO:0002830"(positive regulation of type 2 immune response)|go:"GO:0002906"(negative regulation of mature B cell apoptotic process)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005773"(vacuole)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019883"(antigen processing and presentation of endogenous antigen)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0019955"(cytokine binding)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031394"(positive regulation of prostaglandin biosynthetic process)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0035691"(macrophage migration inhibitory factor signaling pathway)|go:"GO:0035692"(macrophage migration inhibitory factor receptor complex)|go:"GO:0035693"(NOS2-CD74 complex)|go:"GO:0035718"(macrophage migration inhibitory factor binding)|go:"GO:0042289"(MHC class II protein binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0042658"(MHC class II protein binding, via antigen binding groove)|go:"GO:0042802"(identical protein binding)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045058"(T cell selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045581"(negative regulation of T cell differentiation)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000448"(positive regulation of macrophage migration inhibitory factor signaling pathway)|interpro:IPR000716(Thyroglobulin type-1)|interpro:IPR011988(MHC class II-associated invariant chain, trimerisation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR015386(MHC class II-associated invariant chain/CLIP, MHC II-interacting)|interpro:IPR022339|interpro:IPR036613|go:"GO:0046597"(negative regulation of viral entry into host cell)|interpro:IPR036857|interpro:IPR043530|mint:P04233|rcsb pdb:1A6A|rcsb pdb:1ICF|rcsb pdb:1IIE|rcsb pdb:1L3H|rcsb pdb:1MUJ|rcsb pdb:3PDO|rcsb pdb:3PGC|rcsb pdb:3PGD|go:"GO:0046598"(positive regulation of viral entry into host cell)|rcsb pdb:3QXA|go:"GO:0048146"(positive regulation of fibroblast proliferation)|rcsb pdb:3QXD|rcsb pdb:4AEN|rcsb pdb:4AH2|rcsb pdb:4X5W|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|rcsb pdb:5KSU|rcsb pdb:5KSV|go:"GO:0050821"(protein stabilization)|reactome:R-HSA-202733|reactome:R-HSA-2132295|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070206"(protein trimerization)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade) - comment:P0DMV8,P0DMV9 - figure legend:2Bii|comment:"Unlabeled CLIP peptide as well as a peptide from tetanus toxin (TT 947–966) showed stronger competition as compared to the HLA-DR-derived peptide fragments."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/20 2020/10/15 - rogid:jP1UH09kpXY45O7Qr5OdAfDDIXY9606 - false - sufficient binding region:105-117|biotin tag:?-? - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation) uniprotkb:P01911 intact:EBI-11820565 intact:EBI-1033104|uniprotkb:O19717|uniprotkb:O19739|uniprotkb:P13759|uniprotkb:Q29875|uniprotkb:Q30145|uniprotkb:Q9GIX9|uniprotkb:Q9GIY4|uniprotkb:Q9MY13|uniprotkb:Q9XRY5|uniprotkb:Q0PQ39|uniprotkb:Q14280|uniprotkb:Q14QT2|uniprotkb:Q155F7|uniprotkb:Q19AF2|uniprotkb:Q19K86|uniprotkb:Q1AP33|uniprotkb:Q1G0Z9|uniprotkb:Q1JRP3|uniprotkb:Q1KLJ6|uniprotkb:Q27PR6|uniprotkb:Q27PR7|uniprotkb:Q29673|uniprotkb:Q29720|uniprotkb:Q29722|uniprotkb:Q29734|uniprotkb:Q29770|uniprotkb:Q29771|uniprotkb:A0MWF2|uniprotkb:A0N0W1|uniprotkb:A2ICT1|uniprotkb:A2TGX3|uniprotkb:A4F5N0|uniprotkb:A4ZXA5|uniprotkb:A4ZXA6|uniprotkb:A4ZY86|uniprotkb:A5H000|ensembl:ENSP00000353099|uniprotkb:A5HKN8|uniprotkb:A7DZP9|uniprotkb:A7LA26|uniprotkb:A7UHG2|uniprotkb:A7X5B1|uniprotkb:A7X5B7|uniprotkb:A7X5E0|uniprotkb:A7X5E6|uniprotkb:A7X5H8|uniprotkb:A7X5J4|uniprotkb:A7X5K7|uniprotkb:A8K098|uniprotkb:A8YQE9|uniprotkb:A9JPG0|uniprotkb:B0BK85|uniprotkb:B1GWE7|uniprotkb:B2CR03|uniprotkb:B0LUZ6|uniprotkb:B0UYW1|uniprotkb:Q768U2|uniprotkb:Q29772|uniprotkb:Q29790|uniprotkb:Q29792|uniprotkb:Q29800|uniprotkb:Q29806|uniprotkb:Q29833|uniprotkb:Q29874|uniprotkb:Q29886|uniprotkb:Q29968|uniprotkb:Q29974|uniprotkb:Q29975|uniprotkb:Q2A120|uniprotkb:Q2HZE5|uniprotkb:Q2L9H4|uniprotkb:Q2LE76|uniprotkb:Q2MF40|uniprotkb:Q2MJA6|uniprotkb:Q2MZ92|uniprotkb:Q2VQU1|uniprotkb:Q2YHQ2|uniprotkb:Q30006|uniprotkb:Q30108|uniprotkb:Q30112|uniprotkb:Q30115|uniprotkb:Q30116|uniprotkb:Q30117|uniprotkb:Q30120|uniprotkb:Q30134|uniprotkb:Q30142|uniprotkb:Q30149|uniprotkb:Q30159|uniprotkb:Q30166|uniprotkb:Q30167|uniprotkb:Q30200|uniprotkb:Q307W5|uniprotkb:Q31636|uniprotkb:Q32MY7|uniprotkb:Q3HUP9|uniprotkb:Q3KTM1|uniprotkb:Q3LA84|uniprotkb:Q3LA87|uniprotkb:Q3LA88|uniprotkb:Q3LA89|uniprotkb:Q3LA90|uniprotkb:Q3LA91|uniprotkb:Q3LA92|uniprotkb:Q3LA93|uniprotkb:Q3LA94|uniprotkb:Q3LA95|uniprotkb:Q3LA96|uniprotkb:Q3LA97|uniprotkb:Q3LA98|uniprotkb:Q3LA99|uniprotkb:Q3LAA0|uniprotkb:Q3LAA1|uniprotkb:Q3LAA2|uniprotkb:Q3MQ60|uniprotkb:Q3T919|uniprotkb:Q4PRC3|uniprotkb:Q4PRC5|uniprotkb:Q4VZY7|uniprotkb:Q53IG1|uniprotkb:Q56FN9|uniprotkb:Q56FP1|uniprotkb:Q56FP2|uniprotkb:Q56FP3|uniprotkb:Q58F52|uniprotkb:Q5BM92|uniprotkb:Q5EER6|uniprotkb:Q5K3W2|uniprotkb:Q5NDB9|uniprotkb:Q5U9W6|uniprotkb:Q5UBA2|uniprotkb:Q5UT58|uniprotkb:Q5W3L4|uniprotkb:Q5Y7A7|uniprotkb:Q5Y7B0|uniprotkb:Q5Y7B9|uniprotkb:Q5Y7E9|uniprotkb:Q5Y7G0|uniprotkb:Q683P7|uniprotkb:Q6REE2|uniprotkb:Q6T865|uniprotkb:Q6U387|uniprotkb:Q701T1|uniprotkb:Q70GL2|uniprotkb:Q70Q85|uniprotkb:Q768U4|uniprotkb:Q7M2H4|uniprotkb:Q7YNY9|uniprotkb:Q7YP03|uniprotkb:Q7YP04|uniprotkb:Q7YQ26|uniprotkb:Q7YQA3|uniprotkb:Q7YQA5|uniprotkb:Q860D8|uniprotkb:Q860D9|uniprotkb:Q860E5|uniprotkb:Q860H8|uniprotkb:Q860S0|uniprotkb:Q860Z3|uniprotkb:Q861G6|uniprotkb:Q861H0|uniprotkb:Q861H4|uniprotkb:Q861H5|uniprotkb:Q861H7|uniprotkb:Q861H8|uniprotkb:Q8HWQ6|uniprotkb:Q8MH59|uniprotkb:Q8MH60|uniprotkb:Q8WLU3|uniprotkb:Q8WMA0|uniprotkb:Q95348|uniprotkb:Q95383|uniprotkb:Q95389|uniprotkb:Q95461|uniprotkb:Q95HK1|uniprotkb:Q95HL0|uniprotkb:Q95HL1|uniprotkb:Q95IE3|uniprotkb:Q95IG2|uniprotkb:Q95IT6|uniprotkb:Q96HZ9|uniprotkb:Q9BCL7|uniprotkb:Q9BCP0|uniprotkb:Q9BCP1|uniprotkb:Q9BCP2|uniprotkb:Q9BCP5|uniprotkb:Q9BD21|uniprotkb:Q9BD33|uniprotkb:Q9BD40|uniprotkb:Q9GIK5|uniprotkb:Q9GIL5|uniprotkb:Q9GIL6|uniprotkb:Q9GIP3|uniprotkb:Q9GIX8|uniprotkb:Q9GIY0|uniprotkb:Q9GIY1|uniprotkb:Q9GIY2|uniprotkb:B2LVF9|uniprotkb:B2NJ29|uniprotkb:B2ZCY1|uniprotkb:B3VTP8|uniprotkb:B3VTQ3|uniprotkb:B5A8Y2|uniprotkb:B5A8Y3|uniprotkb:C0LAB5|uniprotkb:B5B8U0|uniprotkb:B5B9V5|uniprotkb:B5B9V6|uniprotkb:B5LZ25|uniprotkb:B5QSK8|uniprotkb:B6VCX2|uniprotkb:B6VEL9|uniprotkb:B7UDB2|uniprotkb:B9VRA4|uniprotkb:B9X248|uniprotkb:Q0PGR5|uniprotkb:O02876|uniprotkb:O02930|uniprotkb:O19585|uniprotkb:O19718|uniprotkb:O19788|uniprotkb:O46699|uniprotkb:O46793|uniprotkb:O46872|uniprotkb:O62869|uniprotkb:O62889|uniprotkb:O77969|uniprotkb:O78047|uniprotkb:O78210|uniprotkb:O98212|uniprotkb:P01912|uniprotkb:P01914|uniprotkb:P04229|uniprotkb:P13758|uniprotkb:P13760|uniprotkb:P13761|uniprotkb:P20039|uniprotkb:P79545|uniprotkb:Q06662|intact:EBI-3866098|intact:EBI-13953066|uniprotkb:Q9GIY3|uniprotkb:Q9GJ25|uniprotkb:Q9GJ56|uniprotkb:Q9GJ57|uniprotkb:Q9GJ58|uniprotkb:Q9GJ60|uniprotkb:Q9GJF8|uniprotkb:Q9GJF9|uniprotkb:Q9GJG0|uniprotkb:Q9MXZ0|uniprotkb:Q9MXZ5|uniprotkb:Q9MY45|uniprotkb:Q9MY56|uniprotkb:Q9MYF5|uniprotkb:Q9TPB6|uniprotkb:Q9TPW1|uniprotkb:Q9TPW3|uniprotkb:Q9TPW9|uniprotkb:Q9TPX4|uniprotkb:Q9TQ37|uniprotkb:Q9TQ91|uniprotkb:Q9TQE0|uniprotkb:Q9UBY1|uniprotkb:Q9UIM9|uniprotkb:Q9UIN0|uniprotkb:Q9XRX1|uniprotkb:Q9XRY4|uniprotkb:Q9Y453|uniprotkb:Q9Y4H7|intact:EBI-13953170|intact:EBI-2877159 - psi-mi:drb1_human(display_long)|uniprotkb:HLA-DRB1(gene name)|psi-mi:HLA-DRB1(display_short)|uniprotkb:Human leukocyte antigen DRB1(gene name synonym) psi-mi:hspa1a_hspa1b_human-1(display_short)|psi-mi:EBI-11820565(display_long) psi-mi:"MI:0892"(solid phase assay) Haug et al. (2007) imex:IM-25683|pubmed:17357109 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-13952785|imex:IM-25683-18 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:1304"(molecule set) refseq:NP_002115.2|ensembl:ENSG00000196126(gene)|ensembl:ENST00000360004(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001772"(immunological synapse)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0002469"(myeloid dendritic cell antigen processing and presentation)|go:"GO:0002491"(antigen processing and presentation of endogenous peptide antigen via MHC class II)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0002842"(positive regulation of T cell mediated immune response to tumor cell)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005615"(extracellular space)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0008544"(epidermis development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016045"(detection of bacterium)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030247"(polysaccharide binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032395"(MHC class II receptor activity)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032653"(regulation of interleukin-10 production)|go:"GO:0032673"(regulation of interleukin-4 production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032831"(positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043382"(positive regulation of memory T cell differentiation)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045622"(regulation of T-helper cell differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046598"(positive regulation of viral entry into host cell)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2000516"(positive regulation of CD4-positive, alpha-beta T cell activation)|interpro:IPR000353(MHC class II, beta chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1A6A|rcsb pdb:1AQD|rcsb pdb:1BX2|rcsb pdb:1D5M|rcsb pdb:1D5X|rcsb pdb:1D5Z|rcsb pdb:1D6E|rcsb pdb:1DLH|rcsb pdb:1FYT|rcsb pdb:1HXY|rcsb pdb:1J8H|rcsb pdb:1JWM|rcsb pdb:1JWS|rcsb pdb:1JWU|rcsb pdb:1KG0|rcsb pdb:1KLG|rcsb pdb:1KLU|rcsb pdb:1LO5|rcsb pdb:1PYW|rcsb pdb:1R5I|rcsb pdb:1SEB|rcsb pdb:1SJE|rcsb pdb:1SJH|rcsb pdb:1T5W|rcsb pdb:1T5X|rcsb pdb:1YMM|rcsb pdb:2FSE|rcsb pdb:2G9H|rcsb pdb:2IAM|rcsb pdb:2IAN|rcsb pdb:2ICW|rcsb pdb:2IPK|rcsb pdb:2OJE|rcsb pdb:2SEB|rcsb pdb:2WBJ|rcsb pdb:2XN9|rcsb pdb:3L6F|rcsb pdb:3O6F|rcsb pdb:3PDO|rcsb pdb:3PGC|rcsb pdb:3PGD|rcsb pdb:3QXA|rcsb pdb:3QXD|rcsb pdb:3S4S|rcsb pdb:3S5L|rcsb pdb:3T0E|rcsb pdb:4AEN|rcsb pdb:4AH2|rcsb pdb:4C56|rcsb pdb:4E41|rcsb pdb:4FQX|rcsb pdb:4GBX|rcsb pdb:4I5B|rcsb pdb:4IS6|rcsb pdb:4MCY|rcsb pdb:4MCZ|rcsb pdb:4MD0|rcsb pdb:4MD4|rcsb pdb:4MD5|rcsb pdb:4MDI|rcsb pdb:4MDJ|rcsb pdb:4OV5|rcsb pdb:4X5W|rcsb pdb:4X5X|rcsb pdb:4Y19|rcsb pdb:4Y1A|rcsb pdb:5JLZ|rcsb pdb:5LAX|rcsb pdb:5NI9|rcsb pdb:5NIG|rcsb pdb:6BIJ|rcsb pdb:6BIL|rcsb pdb:6BIN|rcsb pdb:6BIR|rcsb pdb:6BIV|rcsb pdb:6BIX|rcsb pdb:6BIY|rcsb pdb:6BIZ|rcsb pdb:6CPL|rcsb pdb:6CPN|rcsb pdb:6CPO|rcsb pdb:6CQJ|rcsb pdb:6CQL|rcsb pdb:6CQN|rcsb pdb:6CQQ|rcsb pdb:6CQR|rcsb pdb:6HBY|rcsb pdb:6NIX|rcsb pdb:6QZA|rcsb pdb:6QZC|rcsb pdb:6QZD|rcsb pdb:6R0E|rcsb pdb:6V0Y|rcsb pdb:6V13|rcsb pdb:6V15|rcsb pdb:6V18|rcsb pdb:6V19|rcsb pdb:6V1A|reactome:R-HSA-202424|reactome:R-HSA-202427|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-2132295|reactome:R-HSA-389948|reactome:R-HSA-877300|refseq:XP_011546040.1|refseq:NP_001230894.1 - - - comment:P0DMV8,P0DMV9 figure legend:4 A/B, 5, 6,7B|comment:HLA-DRB1*0401|agonist:Binding is greater at pH 5 than pH 7.|comment:Hsc70 also bound HLA-DRB1*0401 to a greater extent at pH=5 than pH 7, but the origins of this molecule could not be clarified.|kinetics:"pH7 - Kd =113nM (as shown in figure 5) pH5 - Kd = 15nM (as shown in figure 5) From several experiments, a KD of 130 nM was calculated at pH 7 and of 26.6 nM at pH 5. (results not shown)"|agonist:ATP|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/20 2020/10/15 rogid:YdQX0KNIxO5tYjgm6hdRRZfNlk49606 - - false biotin tag:?-? - - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation) uniprotkb:P01911 uniprotkb:P0A6Y8 intact:EBI-1033104|uniprotkb:O19717|uniprotkb:O19739|uniprotkb:P13759|uniprotkb:Q29875|uniprotkb:Q30145|uniprotkb:Q9GIX9|uniprotkb:Q9GIY4|uniprotkb:Q9MY13|uniprotkb:Q9XRY5|uniprotkb:Q0PQ39|uniprotkb:Q14280|uniprotkb:Q14QT2|uniprotkb:Q155F7|uniprotkb:Q19AF2|uniprotkb:Q19K86|uniprotkb:Q1AP33|uniprotkb:Q1G0Z9|uniprotkb:Q1JRP3|uniprotkb:Q1KLJ6|uniprotkb:Q27PR6|uniprotkb:Q27PR7|uniprotkb:Q29673|uniprotkb:Q29720|uniprotkb:Q29722|uniprotkb:Q29734|uniprotkb:Q29770|uniprotkb:Q29771|uniprotkb:A0MWF2|uniprotkb:A0N0W1|uniprotkb:A2ICT1|uniprotkb:A2TGX3|uniprotkb:A4F5N0|uniprotkb:A4ZXA5|uniprotkb:A4ZXA6|uniprotkb:A4ZY86|uniprotkb:A5H000|ensembl:ENSP00000353099|uniprotkb:A5HKN8|uniprotkb:A7DZP9|uniprotkb:A7LA26|uniprotkb:A7UHG2|uniprotkb:A7X5B1|uniprotkb:A7X5B7|uniprotkb:A7X5E0|uniprotkb:A7X5E6|uniprotkb:A7X5H8|uniprotkb:A7X5J4|uniprotkb:A7X5K7|uniprotkb:A8K098|uniprotkb:A8YQE9|uniprotkb:A9JPG0|uniprotkb:B0BK85|uniprotkb:B1GWE7|uniprotkb:B2CR03|uniprotkb:B0LUZ6|uniprotkb:B0UYW1|uniprotkb:Q768U2|uniprotkb:Q29772|uniprotkb:Q29790|uniprotkb:Q29792|uniprotkb:Q29800|uniprotkb:Q29806|uniprotkb:Q29833|uniprotkb:Q29874|uniprotkb:Q29886|uniprotkb:Q29968|uniprotkb:Q29974|uniprotkb:Q29975|uniprotkb:Q2A120|uniprotkb:Q2HZE5|uniprotkb:Q2L9H4|uniprotkb:Q2LE76|uniprotkb:Q2MF40|uniprotkb:Q2MJA6|uniprotkb:Q2MZ92|uniprotkb:Q2VQU1|uniprotkb:Q2YHQ2|uniprotkb:Q30006|uniprotkb:Q30108|uniprotkb:Q30112|uniprotkb:Q30115|uniprotkb:Q30116|uniprotkb:Q30117|uniprotkb:Q30120|uniprotkb:Q30134|uniprotkb:Q30142|uniprotkb:Q30149|uniprotkb:Q30159|uniprotkb:Q30166|uniprotkb:Q30167|uniprotkb:Q30200|uniprotkb:Q307W5|uniprotkb:Q31636|uniprotkb:Q32MY7|uniprotkb:Q3HUP9|uniprotkb:Q3KTM1|uniprotkb:Q3LA84|uniprotkb:Q3LA87|uniprotkb:Q3LA88|uniprotkb:Q3LA89|uniprotkb:Q3LA90|uniprotkb:Q3LA91|uniprotkb:Q3LA92|uniprotkb:Q3LA93|uniprotkb:Q3LA94|uniprotkb:Q3LA95|uniprotkb:Q3LA96|uniprotkb:Q3LA97|uniprotkb:Q3LA98|uniprotkb:Q3LA99|uniprotkb:Q3LAA0|uniprotkb:Q3LAA1|uniprotkb:Q3LAA2|uniprotkb:Q3MQ60|uniprotkb:Q3T919|uniprotkb:Q4PRC3|uniprotkb:Q4PRC5|uniprotkb:Q4VZY7|uniprotkb:Q53IG1|uniprotkb:Q56FN9|uniprotkb:Q56FP1|uniprotkb:Q56FP2|uniprotkb:Q56FP3|uniprotkb:Q58F52|uniprotkb:Q5BM92|uniprotkb:Q5EER6|uniprotkb:Q5K3W2|uniprotkb:Q5NDB9|uniprotkb:Q5U9W6|uniprotkb:Q5UBA2|uniprotkb:Q5UT58|uniprotkb:Q5W3L4|uniprotkb:Q5Y7A7|uniprotkb:Q5Y7B0|uniprotkb:Q5Y7B9|uniprotkb:Q5Y7E9|uniprotkb:Q5Y7G0|uniprotkb:Q683P7|uniprotkb:Q6REE2|uniprotkb:Q6T865|uniprotkb:Q6U387|uniprotkb:Q701T1|uniprotkb:Q70GL2|uniprotkb:Q70Q85|uniprotkb:Q768U4|uniprotkb:Q7M2H4|uniprotkb:Q7YNY9|uniprotkb:Q7YP03|uniprotkb:Q7YP04|uniprotkb:Q7YQ26|uniprotkb:Q7YQA3|uniprotkb:Q7YQA5|uniprotkb:Q860D8|uniprotkb:Q860D9|uniprotkb:Q860E5|uniprotkb:Q860H8|uniprotkb:Q860S0|uniprotkb:Q860Z3|uniprotkb:Q861G6|uniprotkb:Q861H0|uniprotkb:Q861H4|uniprotkb:Q861H5|uniprotkb:Q861H7|uniprotkb:Q861H8|uniprotkb:Q8HWQ6|uniprotkb:Q8MH59|uniprotkb:Q8MH60|uniprotkb:Q8WLU3|uniprotkb:Q8WMA0|uniprotkb:Q95348|uniprotkb:Q95383|uniprotkb:Q95389|uniprotkb:Q95461|uniprotkb:Q95HK1|uniprotkb:Q95HL0|uniprotkb:Q95HL1|uniprotkb:Q95IE3|uniprotkb:Q95IG2|uniprotkb:Q95IT6|uniprotkb:Q96HZ9|uniprotkb:Q9BCL7|uniprotkb:Q9BCP0|uniprotkb:Q9BCP1|uniprotkb:Q9BCP2|uniprotkb:Q9BCP5|uniprotkb:Q9BD21|uniprotkb:Q9BD33|uniprotkb:Q9BD40|uniprotkb:Q9GIK5|uniprotkb:Q9GIL5|uniprotkb:Q9GIL6|uniprotkb:Q9GIP3|uniprotkb:Q9GIX8|uniprotkb:Q9GIY0|uniprotkb:Q9GIY1|uniprotkb:Q9GIY2|uniprotkb:B2LVF9|uniprotkb:B2NJ29|uniprotkb:B2ZCY1|uniprotkb:B3VTP8|uniprotkb:B3VTQ3|uniprotkb:B5A8Y2|uniprotkb:B5A8Y3|uniprotkb:C0LAB5|uniprotkb:B5B8U0|uniprotkb:B5B9V5|uniprotkb:B5B9V6|uniprotkb:B5LZ25|uniprotkb:B5QSK8|uniprotkb:B6VCX2|uniprotkb:B6VEL9|uniprotkb:B7UDB2|uniprotkb:B9VRA4|uniprotkb:B9X248|uniprotkb:Q0PGR5|uniprotkb:O02876|uniprotkb:O02930|uniprotkb:O19585|uniprotkb:O19718|uniprotkb:O19788|uniprotkb:O46699|uniprotkb:O46793|uniprotkb:O46872|uniprotkb:O62869|uniprotkb:O62889|uniprotkb:O77969|uniprotkb:O78047|uniprotkb:O78210|uniprotkb:O98212|uniprotkb:P01912|uniprotkb:P01914|uniprotkb:P04229|uniprotkb:P13758|uniprotkb:P13760|uniprotkb:P13761|uniprotkb:P20039|uniprotkb:P79545|uniprotkb:Q06662|intact:EBI-3866098|intact:EBI-13953066|uniprotkb:Q9GIY3|uniprotkb:Q9GJ25|uniprotkb:Q9GJ56|uniprotkb:Q9GJ57|uniprotkb:Q9GJ58|uniprotkb:Q9GJ60|uniprotkb:Q9GJF8|uniprotkb:Q9GJF9|uniprotkb:Q9GJG0|uniprotkb:Q9MXZ0|uniprotkb:Q9MXZ5|uniprotkb:Q9MY45|uniprotkb:Q9MY56|uniprotkb:Q9MYF5|uniprotkb:Q9TPB6|uniprotkb:Q9TPW1|uniprotkb:Q9TPW3|uniprotkb:Q9TPW9|uniprotkb:Q9TPX4|uniprotkb:Q9TQ37|uniprotkb:Q9TQ91|uniprotkb:Q9TQE0|uniprotkb:Q9UBY1|uniprotkb:Q9UIM9|uniprotkb:Q9UIN0|uniprotkb:Q9XRX1|uniprotkb:Q9XRY4|uniprotkb:Q9Y453|uniprotkb:Q9Y4H7|intact:EBI-13953170|intact:EBI-2877159 intact:EBI-542092|uniprotkb:P04475|ensemblbacteria:AAC73125|ensemblbacteria:BAB96589 psi-mi:drb1_human(display_long)|uniprotkb:HLA-DRB1(gene name)|psi-mi:HLA-DRB1(display_short)|uniprotkb:Human leukocyte antigen DRB1(gene name synonym) psi-mi:dnak_ecoli(display_long)|uniprotkb:dnaK(gene name)|psi-mi:dnaK(display_short)|uniprotkb:groP(gene name synonym)|uniprotkb:grpF(gene name synonym)|uniprotkb:seg(gene name synonym)|uniprotkb:b0014(locus name)|uniprotkb:Heat shock protein 70(gene name synonym)|uniprotkb:Heat shock 70 kDa protein(gene name synonym)|uniprotkb:HSP70(gene name synonym)|uniprotkb:JW0013(locus name) psi-mi:"MI:0892"(solid phase assay) Haug et al. (2007) imex:IM-25683|pubmed:17357109 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-13952864|imex:IM-25683-19 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002115.2|ensembl:ENSG00000196126(gene)|ensembl:ENST00000360004(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001772"(immunological synapse)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0002469"(myeloid dendritic cell antigen processing and presentation)|go:"GO:0002491"(antigen processing and presentation of endogenous peptide antigen via MHC class II)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0002842"(positive regulation of T cell mediated immune response to tumor cell)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005615"(extracellular space)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0008544"(epidermis development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016045"(detection of bacterium)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030247"(polysaccharide binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032395"(MHC class II receptor activity)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032653"(regulation of interleukin-10 production)|go:"GO:0032673"(regulation of interleukin-4 production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032831"(positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043382"(positive regulation of memory T cell differentiation)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045622"(regulation of T-helper cell differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046598"(positive regulation of viral entry into host cell)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2000516"(positive regulation of CD4-positive, alpha-beta T cell activation)|interpro:IPR000353(MHC class II, beta chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1A6A|rcsb pdb:1AQD|rcsb pdb:1BX2|rcsb pdb:1D5M|rcsb pdb:1D5X|rcsb pdb:1D5Z|rcsb pdb:1D6E|rcsb pdb:1DLH|rcsb pdb:1FYT|rcsb pdb:1HXY|rcsb pdb:1J8H|rcsb pdb:1JWM|rcsb pdb:1JWS|rcsb pdb:1JWU|rcsb pdb:1KG0|rcsb pdb:1KLG|rcsb pdb:1KLU|rcsb pdb:1LO5|rcsb pdb:1PYW|rcsb pdb:1R5I|rcsb pdb:1SEB|rcsb pdb:1SJE|rcsb pdb:1SJH|rcsb pdb:1T5W|rcsb pdb:1T5X|rcsb pdb:1YMM|rcsb pdb:2FSE|rcsb pdb:2G9H|rcsb pdb:2IAM|rcsb pdb:2IAN|rcsb pdb:2ICW|rcsb pdb:2IPK|rcsb pdb:2OJE|rcsb pdb:2SEB|rcsb pdb:2WBJ|rcsb pdb:2XN9|rcsb pdb:3L6F|rcsb pdb:3O6F|rcsb pdb:3PDO|rcsb pdb:3PGC|rcsb pdb:3PGD|rcsb pdb:3QXA|rcsb pdb:3QXD|rcsb pdb:3S4S|rcsb pdb:3S5L|rcsb pdb:3T0E|rcsb pdb:4AEN|rcsb pdb:4AH2|rcsb pdb:4C56|rcsb pdb:4E41|rcsb pdb:4FQX|rcsb pdb:4GBX|rcsb pdb:4I5B|rcsb pdb:4IS6|rcsb pdb:4MCY|rcsb pdb:4MCZ|rcsb pdb:4MD0|rcsb pdb:4MD4|rcsb pdb:4MD5|rcsb pdb:4MDI|rcsb pdb:4MDJ|rcsb pdb:4OV5|rcsb pdb:4X5W|rcsb pdb:4X5X|rcsb pdb:4Y19|rcsb pdb:4Y1A|rcsb pdb:5JLZ|rcsb pdb:5LAX|rcsb pdb:5NI9|rcsb pdb:5NIG|rcsb pdb:6BIJ|rcsb pdb:6BIL|rcsb pdb:6BIN|rcsb pdb:6BIR|rcsb pdb:6BIV|rcsb pdb:6BIX|rcsb pdb:6BIY|rcsb pdb:6BIZ|rcsb pdb:6CPL|rcsb pdb:6CPN|rcsb pdb:6CPO|rcsb pdb:6CQJ|rcsb pdb:6CQL|rcsb pdb:6CQN|rcsb pdb:6CQQ|rcsb pdb:6CQR|rcsb pdb:6HBY|rcsb pdb:6NIX|rcsb pdb:6QZA|rcsb pdb:6QZC|rcsb pdb:6QZD|rcsb pdb:6R0E|rcsb pdb:6V0Y|rcsb pdb:6V13|rcsb pdb:6V15|rcsb pdb:6V18|rcsb pdb:6V19|rcsb pdb:6V1A|reactome:R-HSA-202424|reactome:R-HSA-202427|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-2132295|reactome:R-HSA-389948|reactome:R-HSA-877300|refseq:XP_011546040.1|refseq:NP_001230894.1 refseq:NP_414555.1|ensemblbacteria:AAC73125(transcript)|ensemblbacteria:b0014(gene)|ensemblbacteria:BAB96589(gene)|ensemblbacteria:BAB96589(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006260"(DNA replication)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009408"(response to heat)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016989"(sigma factor antagonist activity)|go:"GO:0032984"(protein-containing complex disassembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0043531"(ADP binding)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR012725(Chaperone DnaK)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|rcsb pdb:1BPR|rcsb pdb:1DG4|rcsb pdb:1DKG|rcsb pdb:1DKX|rcsb pdb:1DKY|rcsb pdb:1DKZ|rcsb pdb:1Q5L|rcsb pdb:2BPR|rcsb pdb:2KHO|rcsb pdb:3DPO|rcsb pdb:3DPP|rcsb pdb:3DPQ|rcsb pdb:3QNJ|rcsb pdb:4B9Q|rcsb pdb:4E81|rcsb pdb:4EZN|rcsb pdb:4EZO|rcsb pdb:4EZP|rcsb pdb:4EZR|rcsb pdb:4EZS|rcsb pdb:4EZT|rcsb pdb:4EZU|rcsb pdb:4EZV|rcsb pdb:4EZW|rcsb pdb:4EZX|rcsb pdb:4EZY|rcsb pdb:4EZZ|rcsb pdb:4F00|rcsb pdb:4F01|rcsb pdb:4HY9|rcsb pdb:4HYB|rcsb pdb:4JN4|rcsb pdb:4JNE|rcsb pdb:4JNF|rcsb pdb:4JWC|rcsb pdb:4JWD|rcsb pdb:4JWE|rcsb pdb:4JWI|rcsb pdb:4R5G|rcsb pdb:4R5I|rcsb pdb:4R5J|rcsb pdb:4R5K|rcsb pdb:4R5L|rcsb pdb:5NRO|rcsb pdb:5OOW|rcsb pdb:7JMM|rcsb pdb:7JN8|rcsb pdb:7JN9|rcsb pdb:7JNE|rcsb pdb:7N6J|rcsb pdb:7N6K|rcsb pdb:7N6L|rcsb pdb:7N6M|rcsb pdb:4EZQ|refseq:WP_000516135.1|mint:P0A6Y8|dip:DIP-35751N - - - figure legend:4 A/Bi|comment:HLA-DRB1*0401 weak binding|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/20 2020/01/07 rogid:YdQX0KNIxO5tYjgm6hdRRZfNlk49606 rogid:jm8ErX3H3EOAYYuSDcddoE/NQx483333 rigid:XSq0IpQRV6mu98tpgSv6JAJ5JC8 false biotin tag:?-? - - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation) intact:EBI-11820565 uniprotkb:P01911 - intact:EBI-1033104|uniprotkb:O19717|uniprotkb:O19739|uniprotkb:P13759|uniprotkb:Q29875|uniprotkb:Q30145|uniprotkb:Q9GIX9|uniprotkb:Q9GIY4|uniprotkb:Q9MY13|uniprotkb:Q9XRY5|uniprotkb:Q0PQ39|uniprotkb:Q14280|uniprotkb:Q14QT2|uniprotkb:Q155F7|uniprotkb:Q19AF2|uniprotkb:Q19K86|uniprotkb:Q1AP33|uniprotkb:Q1G0Z9|uniprotkb:Q1JRP3|uniprotkb:Q1KLJ6|uniprotkb:Q27PR6|uniprotkb:Q27PR7|uniprotkb:Q29673|uniprotkb:Q29720|uniprotkb:Q29722|uniprotkb:Q29734|uniprotkb:Q29770|uniprotkb:Q29771|uniprotkb:A0MWF2|uniprotkb:A0N0W1|uniprotkb:A2ICT1|uniprotkb:A2TGX3|uniprotkb:A4F5N0|uniprotkb:A4ZXA5|uniprotkb:A4ZXA6|uniprotkb:A4ZY86|uniprotkb:A5H000|ensembl:ENSP00000353099|uniprotkb:A5HKN8|uniprotkb:A7DZP9|uniprotkb:A7LA26|uniprotkb:A7UHG2|uniprotkb:A7X5B1|uniprotkb:A7X5B7|uniprotkb:A7X5E0|uniprotkb:A7X5E6|uniprotkb:A7X5H8|uniprotkb:A7X5J4|uniprotkb:A7X5K7|uniprotkb:A8K098|uniprotkb:A8YQE9|uniprotkb:A9JPG0|uniprotkb:B0BK85|uniprotkb:B1GWE7|uniprotkb:B2CR03|uniprotkb:B0LUZ6|uniprotkb:B0UYW1|uniprotkb:Q768U2|uniprotkb:Q29772|uniprotkb:Q29790|uniprotkb:Q29792|uniprotkb:Q29800|uniprotkb:Q29806|uniprotkb:Q29833|uniprotkb:Q29874|uniprotkb:Q29886|uniprotkb:Q29968|uniprotkb:Q29974|uniprotkb:Q29975|uniprotkb:Q2A120|uniprotkb:Q2HZE5|uniprotkb:Q2L9H4|uniprotkb:Q2LE76|uniprotkb:Q2MF40|uniprotkb:Q2MJA6|uniprotkb:Q2MZ92|uniprotkb:Q2VQU1|uniprotkb:Q2YHQ2|uniprotkb:Q30006|uniprotkb:Q30108|uniprotkb:Q30112|uniprotkb:Q30115|uniprotkb:Q30116|uniprotkb:Q30117|uniprotkb:Q30120|uniprotkb:Q30134|uniprotkb:Q30142|uniprotkb:Q30149|uniprotkb:Q30159|uniprotkb:Q30166|uniprotkb:Q30167|uniprotkb:Q30200|uniprotkb:Q307W5|uniprotkb:Q31636|uniprotkb:Q32MY7|uniprotkb:Q3HUP9|uniprotkb:Q3KTM1|uniprotkb:Q3LA84|uniprotkb:Q3LA87|uniprotkb:Q3LA88|uniprotkb:Q3LA89|uniprotkb:Q3LA90|uniprotkb:Q3LA91|uniprotkb:Q3LA92|uniprotkb:Q3LA93|uniprotkb:Q3LA94|uniprotkb:Q3LA95|uniprotkb:Q3LA96|uniprotkb:Q3LA97|uniprotkb:Q3LA98|uniprotkb:Q3LA99|uniprotkb:Q3LAA0|uniprotkb:Q3LAA1|uniprotkb:Q3LAA2|uniprotkb:Q3MQ60|uniprotkb:Q3T919|uniprotkb:Q4PRC3|uniprotkb:Q4PRC5|uniprotkb:Q4VZY7|uniprotkb:Q53IG1|uniprotkb:Q56FN9|uniprotkb:Q56FP1|uniprotkb:Q56FP2|uniprotkb:Q56FP3|uniprotkb:Q58F52|uniprotkb:Q5BM92|uniprotkb:Q5EER6|uniprotkb:Q5K3W2|uniprotkb:Q5NDB9|uniprotkb:Q5U9W6|uniprotkb:Q5UBA2|uniprotkb:Q5UT58|uniprotkb:Q5W3L4|uniprotkb:Q5Y7A7|uniprotkb:Q5Y7B0|uniprotkb:Q5Y7B9|uniprotkb:Q5Y7E9|uniprotkb:Q5Y7G0|uniprotkb:Q683P7|uniprotkb:Q6REE2|uniprotkb:Q6T865|uniprotkb:Q6U387|uniprotkb:Q701T1|uniprotkb:Q70GL2|uniprotkb:Q70Q85|uniprotkb:Q768U4|uniprotkb:Q7M2H4|uniprotkb:Q7YNY9|uniprotkb:Q7YP03|uniprotkb:Q7YP04|uniprotkb:Q7YQ26|uniprotkb:Q7YQA3|uniprotkb:Q7YQA5|uniprotkb:Q860D8|uniprotkb:Q860D9|uniprotkb:Q860E5|uniprotkb:Q860H8|uniprotkb:Q860S0|uniprotkb:Q860Z3|uniprotkb:Q861G6|uniprotkb:Q861H0|uniprotkb:Q861H4|uniprotkb:Q861H5|uniprotkb:Q861H7|uniprotkb:Q861H8|uniprotkb:Q8HWQ6|uniprotkb:Q8MH59|uniprotkb:Q8MH60|uniprotkb:Q8WLU3|uniprotkb:Q8WMA0|uniprotkb:Q95348|uniprotkb:Q95383|uniprotkb:Q95389|uniprotkb:Q95461|uniprotkb:Q95HK1|uniprotkb:Q95HL0|uniprotkb:Q95HL1|uniprotkb:Q95IE3|uniprotkb:Q95IG2|uniprotkb:Q95IT6|uniprotkb:Q96HZ9|uniprotkb:Q9BCL7|uniprotkb:Q9BCP0|uniprotkb:Q9BCP1|uniprotkb:Q9BCP2|uniprotkb:Q9BCP5|uniprotkb:Q9BD21|uniprotkb:Q9BD33|uniprotkb:Q9BD40|uniprotkb:Q9GIK5|uniprotkb:Q9GIL5|uniprotkb:Q9GIL6|uniprotkb:Q9GIP3|uniprotkb:Q9GIX8|uniprotkb:Q9GIY0|uniprotkb:Q9GIY1|uniprotkb:Q9GIY2|uniprotkb:B2LVF9|uniprotkb:B2NJ29|uniprotkb:B2ZCY1|uniprotkb:B3VTP8|uniprotkb:B3VTQ3|uniprotkb:B5A8Y2|uniprotkb:B5A8Y3|uniprotkb:C0LAB5|uniprotkb:B5B8U0|uniprotkb:B5B9V5|uniprotkb:B5B9V6|uniprotkb:B5LZ25|uniprotkb:B5QSK8|uniprotkb:B6VCX2|uniprotkb:B6VEL9|uniprotkb:B7UDB2|uniprotkb:B9VRA4|uniprotkb:B9X248|uniprotkb:Q0PGR5|uniprotkb:O02876|uniprotkb:O02930|uniprotkb:O19585|uniprotkb:O19718|uniprotkb:O19788|uniprotkb:O46699|uniprotkb:O46793|uniprotkb:O46872|uniprotkb:O62869|uniprotkb:O62889|uniprotkb:O77969|uniprotkb:O78047|uniprotkb:O78210|uniprotkb:O98212|uniprotkb:P01912|uniprotkb:P01914|uniprotkb:P04229|uniprotkb:P13758|uniprotkb:P13760|uniprotkb:P13761|uniprotkb:P20039|uniprotkb:P79545|uniprotkb:Q06662|intact:EBI-3866098|intact:EBI-13953066|uniprotkb:Q9GIY3|uniprotkb:Q9GJ25|uniprotkb:Q9GJ56|uniprotkb:Q9GJ57|uniprotkb:Q9GJ58|uniprotkb:Q9GJ60|uniprotkb:Q9GJF8|uniprotkb:Q9GJF9|uniprotkb:Q9GJG0|uniprotkb:Q9MXZ0|uniprotkb:Q9MXZ5|uniprotkb:Q9MY45|uniprotkb:Q9MY56|uniprotkb:Q9MYF5|uniprotkb:Q9TPB6|uniprotkb:Q9TPW1|uniprotkb:Q9TPW3|uniprotkb:Q9TPW9|uniprotkb:Q9TPX4|uniprotkb:Q9TQ37|uniprotkb:Q9TQ91|uniprotkb:Q9TQE0|uniprotkb:Q9UBY1|uniprotkb:Q9UIM9|uniprotkb:Q9UIN0|uniprotkb:Q9XRX1|uniprotkb:Q9XRY4|uniprotkb:Q9Y453|uniprotkb:Q9Y4H7|intact:EBI-13953170|intact:EBI-2877159 psi-mi:hspa1a_hspa1b_human-1(display_short)|psi-mi:EBI-11820565(display_long) psi-mi:drb1_human(display_long)|uniprotkb:HLA-DRB1(gene name)|psi-mi:HLA-DRB1(display_short)|uniprotkb:Human leukocyte antigen DRB1(gene name synonym) psi-mi:"MI:0892"(solid phase assay) Haug et al. (2007) imex:IM-25683|pubmed:17357109 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13952925|imex:IM-25683-20 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0586"(inhibitor) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:1304"(molecule set) psi-mi:"MI:0326"(protein) - refseq:NP_002115.2|ensembl:ENSG00000196126(gene)|ensembl:ENST00000360004(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001772"(immunological synapse)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0002469"(myeloid dendritic cell antigen processing and presentation)|go:"GO:0002491"(antigen processing and presentation of endogenous peptide antigen via MHC class II)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0002842"(positive regulation of T cell mediated immune response to tumor cell)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005615"(extracellular space)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0008544"(epidermis development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016045"(detection of bacterium)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030247"(polysaccharide binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032395"(MHC class II receptor activity)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032653"(regulation of interleukin-10 production)|go:"GO:0032673"(regulation of interleukin-4 production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032831"(positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043382"(positive regulation of memory T cell differentiation)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045622"(regulation of T-helper cell differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046598"(positive regulation of viral entry into host cell)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2000516"(positive regulation of CD4-positive, alpha-beta T cell activation)|interpro:IPR000353(MHC class II, beta chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1A6A|rcsb pdb:1AQD|rcsb pdb:1BX2|rcsb pdb:1D5M|rcsb pdb:1D5X|rcsb pdb:1D5Z|rcsb pdb:1D6E|rcsb pdb:1DLH|rcsb pdb:1FYT|rcsb pdb:1HXY|rcsb pdb:1J8H|rcsb pdb:1JWM|rcsb pdb:1JWS|rcsb pdb:1JWU|rcsb pdb:1KG0|rcsb pdb:1KLG|rcsb pdb:1KLU|rcsb pdb:1LO5|rcsb pdb:1PYW|rcsb pdb:1R5I|rcsb pdb:1SEB|rcsb pdb:1SJE|rcsb pdb:1SJH|rcsb pdb:1T5W|rcsb pdb:1T5X|rcsb pdb:1YMM|rcsb pdb:2FSE|rcsb pdb:2G9H|rcsb pdb:2IAM|rcsb pdb:2IAN|rcsb pdb:2ICW|rcsb pdb:2IPK|rcsb pdb:2OJE|rcsb pdb:2SEB|rcsb pdb:2WBJ|rcsb pdb:2XN9|rcsb pdb:3L6F|rcsb pdb:3O6F|rcsb pdb:3PDO|rcsb pdb:3PGC|rcsb pdb:3PGD|rcsb pdb:3QXA|rcsb pdb:3QXD|rcsb pdb:3S4S|rcsb pdb:3S5L|rcsb pdb:3T0E|rcsb pdb:4AEN|rcsb pdb:4AH2|rcsb pdb:4C56|rcsb pdb:4E41|rcsb pdb:4FQX|rcsb pdb:4GBX|rcsb pdb:4I5B|rcsb pdb:4IS6|rcsb pdb:4MCY|rcsb pdb:4MCZ|rcsb pdb:4MD0|rcsb pdb:4MD4|rcsb pdb:4MD5|rcsb pdb:4MDI|rcsb pdb:4MDJ|rcsb pdb:4OV5|rcsb pdb:4X5W|rcsb pdb:4X5X|rcsb pdb:4Y19|rcsb pdb:4Y1A|rcsb pdb:5JLZ|rcsb pdb:5LAX|rcsb pdb:5NI9|rcsb pdb:5NIG|rcsb pdb:6BIJ|rcsb pdb:6BIL|rcsb pdb:6BIN|rcsb pdb:6BIR|rcsb pdb:6BIV|rcsb pdb:6BIX|rcsb pdb:6BIY|rcsb pdb:6BIZ|rcsb pdb:6CPL|rcsb pdb:6CPN|rcsb pdb:6CPO|rcsb pdb:6CQJ|rcsb pdb:6CQL|rcsb pdb:6CQN|rcsb pdb:6CQQ|rcsb pdb:6CQR|rcsb pdb:6HBY|rcsb pdb:6NIX|rcsb pdb:6QZA|rcsb pdb:6QZC|rcsb pdb:6QZD|rcsb pdb:6R0E|rcsb pdb:6V0Y|rcsb pdb:6V13|rcsb pdb:6V15|rcsb pdb:6V18|rcsb pdb:6V19|rcsb pdb:6V1A|reactome:R-HSA-202424|reactome:R-HSA-202427|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-2132295|reactome:R-HSA-389948|reactome:R-HSA-877300|refseq:XP_011546040.1|refseq:NP_001230894.1 - comment:P0DMV8,P0DMV9 - figure legend:6-1|comment:HLA-DRB1*0401;Inhibitor HLA-DRB1*1104|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/20 2020/10/15 - rogid:YdQX0KNIxO5tYjgm6hdRRZfNlk49606 - false - - - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation) intact:EBI-11820565 uniprotkb:P01911 - intact:EBI-1033104|uniprotkb:O19717|uniprotkb:O19739|uniprotkb:P13759|uniprotkb:Q29875|uniprotkb:Q30145|uniprotkb:Q9GIX9|uniprotkb:Q9GIY4|uniprotkb:Q9MY13|uniprotkb:Q9XRY5|uniprotkb:Q0PQ39|uniprotkb:Q14280|uniprotkb:Q14QT2|uniprotkb:Q155F7|uniprotkb:Q19AF2|uniprotkb:Q19K86|uniprotkb:Q1AP33|uniprotkb:Q1G0Z9|uniprotkb:Q1JRP3|uniprotkb:Q1KLJ6|uniprotkb:Q27PR6|uniprotkb:Q27PR7|uniprotkb:Q29673|uniprotkb:Q29720|uniprotkb:Q29722|uniprotkb:Q29734|uniprotkb:Q29770|uniprotkb:Q29771|uniprotkb:A0MWF2|uniprotkb:A0N0W1|uniprotkb:A2ICT1|uniprotkb:A2TGX3|uniprotkb:A4F5N0|uniprotkb:A4ZXA5|uniprotkb:A4ZXA6|uniprotkb:A4ZY86|uniprotkb:A5H000|ensembl:ENSP00000353099|uniprotkb:A5HKN8|uniprotkb:A7DZP9|uniprotkb:A7LA26|uniprotkb:A7UHG2|uniprotkb:A7X5B1|uniprotkb:A7X5B7|uniprotkb:A7X5E0|uniprotkb:A7X5E6|uniprotkb:A7X5H8|uniprotkb:A7X5J4|uniprotkb:A7X5K7|uniprotkb:A8K098|uniprotkb:A8YQE9|uniprotkb:A9JPG0|uniprotkb:B0BK85|uniprotkb:B1GWE7|uniprotkb:B2CR03|uniprotkb:B0LUZ6|uniprotkb:B0UYW1|uniprotkb:Q768U2|uniprotkb:Q29772|uniprotkb:Q29790|uniprotkb:Q29792|uniprotkb:Q29800|uniprotkb:Q29806|uniprotkb:Q29833|uniprotkb:Q29874|uniprotkb:Q29886|uniprotkb:Q29968|uniprotkb:Q29974|uniprotkb:Q29975|uniprotkb:Q2A120|uniprotkb:Q2HZE5|uniprotkb:Q2L9H4|uniprotkb:Q2LE76|uniprotkb:Q2MF40|uniprotkb:Q2MJA6|uniprotkb:Q2MZ92|uniprotkb:Q2VQU1|uniprotkb:Q2YHQ2|uniprotkb:Q30006|uniprotkb:Q30108|uniprotkb:Q30112|uniprotkb:Q30115|uniprotkb:Q30116|uniprotkb:Q30117|uniprotkb:Q30120|uniprotkb:Q30134|uniprotkb:Q30142|uniprotkb:Q30149|uniprotkb:Q30159|uniprotkb:Q30166|uniprotkb:Q30167|uniprotkb:Q30200|uniprotkb:Q307W5|uniprotkb:Q31636|uniprotkb:Q32MY7|uniprotkb:Q3HUP9|uniprotkb:Q3KTM1|uniprotkb:Q3LA84|uniprotkb:Q3LA87|uniprotkb:Q3LA88|uniprotkb:Q3LA89|uniprotkb:Q3LA90|uniprotkb:Q3LA91|uniprotkb:Q3LA92|uniprotkb:Q3LA93|uniprotkb:Q3LA94|uniprotkb:Q3LA95|uniprotkb:Q3LA96|uniprotkb:Q3LA97|uniprotkb:Q3LA98|uniprotkb:Q3LA99|uniprotkb:Q3LAA0|uniprotkb:Q3LAA1|uniprotkb:Q3LAA2|uniprotkb:Q3MQ60|uniprotkb:Q3T919|uniprotkb:Q4PRC3|uniprotkb:Q4PRC5|uniprotkb:Q4VZY7|uniprotkb:Q53IG1|uniprotkb:Q56FN9|uniprotkb:Q56FP1|uniprotkb:Q56FP2|uniprotkb:Q56FP3|uniprotkb:Q58F52|uniprotkb:Q5BM92|uniprotkb:Q5EER6|uniprotkb:Q5K3W2|uniprotkb:Q5NDB9|uniprotkb:Q5U9W6|uniprotkb:Q5UBA2|uniprotkb:Q5UT58|uniprotkb:Q5W3L4|uniprotkb:Q5Y7A7|uniprotkb:Q5Y7B0|uniprotkb:Q5Y7B9|uniprotkb:Q5Y7E9|uniprotkb:Q5Y7G0|uniprotkb:Q683P7|uniprotkb:Q6REE2|uniprotkb:Q6T865|uniprotkb:Q6U387|uniprotkb:Q701T1|uniprotkb:Q70GL2|uniprotkb:Q70Q85|uniprotkb:Q768U4|uniprotkb:Q7M2H4|uniprotkb:Q7YNY9|uniprotkb:Q7YP03|uniprotkb:Q7YP04|uniprotkb:Q7YQ26|uniprotkb:Q7YQA3|uniprotkb:Q7YQA5|uniprotkb:Q860D8|uniprotkb:Q860D9|uniprotkb:Q860E5|uniprotkb:Q860H8|uniprotkb:Q860S0|uniprotkb:Q860Z3|uniprotkb:Q861G6|uniprotkb:Q861H0|uniprotkb:Q861H4|uniprotkb:Q861H5|uniprotkb:Q861H7|uniprotkb:Q861H8|uniprotkb:Q8HWQ6|uniprotkb:Q8MH59|uniprotkb:Q8MH60|uniprotkb:Q8WLU3|uniprotkb:Q8WMA0|uniprotkb:Q95348|uniprotkb:Q95383|uniprotkb:Q95389|uniprotkb:Q95461|uniprotkb:Q95HK1|uniprotkb:Q95HL0|uniprotkb:Q95HL1|uniprotkb:Q95IE3|uniprotkb:Q95IG2|uniprotkb:Q95IT6|uniprotkb:Q96HZ9|uniprotkb:Q9BCL7|uniprotkb:Q9BCP0|uniprotkb:Q9BCP1|uniprotkb:Q9BCP2|uniprotkb:Q9BCP5|uniprotkb:Q9BD21|uniprotkb:Q9BD33|uniprotkb:Q9BD40|uniprotkb:Q9GIK5|uniprotkb:Q9GIL5|uniprotkb:Q9GIL6|uniprotkb:Q9GIP3|uniprotkb:Q9GIX8|uniprotkb:Q9GIY0|uniprotkb:Q9GIY1|uniprotkb:Q9GIY2|uniprotkb:B2LVF9|uniprotkb:B2NJ29|uniprotkb:B2ZCY1|uniprotkb:B3VTP8|uniprotkb:B3VTQ3|uniprotkb:B5A8Y2|uniprotkb:B5A8Y3|uniprotkb:C0LAB5|uniprotkb:B5B8U0|uniprotkb:B5B9V5|uniprotkb:B5B9V6|uniprotkb:B5LZ25|uniprotkb:B5QSK8|uniprotkb:B6VCX2|uniprotkb:B6VEL9|uniprotkb:B7UDB2|uniprotkb:B9VRA4|uniprotkb:B9X248|uniprotkb:Q0PGR5|uniprotkb:O02876|uniprotkb:O02930|uniprotkb:O19585|uniprotkb:O19718|uniprotkb:O19788|uniprotkb:O46699|uniprotkb:O46793|uniprotkb:O46872|uniprotkb:O62869|uniprotkb:O62889|uniprotkb:O77969|uniprotkb:O78047|uniprotkb:O78210|uniprotkb:O98212|uniprotkb:P01912|uniprotkb:P01914|uniprotkb:P04229|uniprotkb:P13758|uniprotkb:P13760|uniprotkb:P13761|uniprotkb:P20039|uniprotkb:P79545|uniprotkb:Q06662|intact:EBI-3866098|intact:EBI-13953066|uniprotkb:Q9GIY3|uniprotkb:Q9GJ25|uniprotkb:Q9GJ56|uniprotkb:Q9GJ57|uniprotkb:Q9GJ58|uniprotkb:Q9GJ60|uniprotkb:Q9GJF8|uniprotkb:Q9GJF9|uniprotkb:Q9GJG0|uniprotkb:Q9MXZ0|uniprotkb:Q9MXZ5|uniprotkb:Q9MY45|uniprotkb:Q9MY56|uniprotkb:Q9MYF5|uniprotkb:Q9TPB6|uniprotkb:Q9TPW1|uniprotkb:Q9TPW3|uniprotkb:Q9TPW9|uniprotkb:Q9TPX4|uniprotkb:Q9TQ37|uniprotkb:Q9TQ91|uniprotkb:Q9TQE0|uniprotkb:Q9UBY1|uniprotkb:Q9UIM9|uniprotkb:Q9UIN0|uniprotkb:Q9XRX1|uniprotkb:Q9XRY4|uniprotkb:Q9Y453|uniprotkb:Q9Y4H7|intact:EBI-13953170|intact:EBI-2877159 psi-mi:hspa1a_hspa1b_human-1(display_short)|psi-mi:EBI-11820565(display_long) psi-mi:drb1_human(display_long)|uniprotkb:HLA-DRB1(gene name)|psi-mi:HLA-DRB1(display_short)|uniprotkb:Human leukocyte antigen DRB1(gene name synonym) psi-mi:"MI:0892"(solid phase assay) Haug et al. (2007) imex:IM-25683|pubmed:17357109 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13952925|imex:IM-25683-20 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:1304"(molecule set) psi-mi:"MI:0326"(protein) - refseq:NP_002115.2|ensembl:ENSG00000196126(gene)|ensembl:ENST00000360004(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001772"(immunological synapse)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0002469"(myeloid dendritic cell antigen processing and presentation)|go:"GO:0002491"(antigen processing and presentation of endogenous peptide antigen via MHC class II)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0002842"(positive regulation of T cell mediated immune response to tumor cell)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005615"(extracellular space)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0008544"(epidermis development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016045"(detection of bacterium)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030247"(polysaccharide binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032395"(MHC class II receptor activity)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032653"(regulation of interleukin-10 production)|go:"GO:0032673"(regulation of interleukin-4 production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032831"(positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043382"(positive regulation of memory T cell differentiation)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045622"(regulation of T-helper cell differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046598"(positive regulation of viral entry into host cell)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2000516"(positive regulation of CD4-positive, alpha-beta T cell activation)|interpro:IPR000353(MHC class II, beta chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1A6A|rcsb pdb:1AQD|rcsb pdb:1BX2|rcsb pdb:1D5M|rcsb pdb:1D5X|rcsb pdb:1D5Z|rcsb pdb:1D6E|rcsb pdb:1DLH|rcsb pdb:1FYT|rcsb pdb:1HXY|rcsb pdb:1J8H|rcsb pdb:1JWM|rcsb pdb:1JWS|rcsb pdb:1JWU|rcsb pdb:1KG0|rcsb pdb:1KLG|rcsb pdb:1KLU|rcsb pdb:1LO5|rcsb pdb:1PYW|rcsb pdb:1R5I|rcsb pdb:1SEB|rcsb pdb:1SJE|rcsb pdb:1SJH|rcsb pdb:1T5W|rcsb pdb:1T5X|rcsb pdb:1YMM|rcsb pdb:2FSE|rcsb pdb:2G9H|rcsb pdb:2IAM|rcsb pdb:2IAN|rcsb pdb:2ICW|rcsb pdb:2IPK|rcsb pdb:2OJE|rcsb pdb:2SEB|rcsb pdb:2WBJ|rcsb pdb:2XN9|rcsb pdb:3L6F|rcsb pdb:3O6F|rcsb pdb:3PDO|rcsb pdb:3PGC|rcsb pdb:3PGD|rcsb pdb:3QXA|rcsb pdb:3QXD|rcsb pdb:3S4S|rcsb pdb:3S5L|rcsb pdb:3T0E|rcsb pdb:4AEN|rcsb pdb:4AH2|rcsb pdb:4C56|rcsb pdb:4E41|rcsb pdb:4FQX|rcsb pdb:4GBX|rcsb pdb:4I5B|rcsb pdb:4IS6|rcsb pdb:4MCY|rcsb pdb:4MCZ|rcsb pdb:4MD0|rcsb pdb:4MD4|rcsb pdb:4MD5|rcsb pdb:4MDI|rcsb pdb:4MDJ|rcsb pdb:4OV5|rcsb pdb:4X5W|rcsb pdb:4X5X|rcsb pdb:4Y19|rcsb pdb:4Y1A|rcsb pdb:5JLZ|rcsb pdb:5LAX|rcsb pdb:5NI9|rcsb pdb:5NIG|rcsb pdb:6BIJ|rcsb pdb:6BIL|rcsb pdb:6BIN|rcsb pdb:6BIR|rcsb pdb:6BIV|rcsb pdb:6BIX|rcsb pdb:6BIY|rcsb pdb:6BIZ|rcsb pdb:6CPL|rcsb pdb:6CPN|rcsb pdb:6CPO|rcsb pdb:6CQJ|rcsb pdb:6CQL|rcsb pdb:6CQN|rcsb pdb:6CQQ|rcsb pdb:6CQR|rcsb pdb:6HBY|rcsb pdb:6NIX|rcsb pdb:6QZA|rcsb pdb:6QZC|rcsb pdb:6QZD|rcsb pdb:6R0E|rcsb pdb:6V0Y|rcsb pdb:6V13|rcsb pdb:6V15|rcsb pdb:6V18|rcsb pdb:6V19|rcsb pdb:6V1A|reactome:R-HSA-202424|reactome:R-HSA-202427|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-2132295|reactome:R-HSA-389948|reactome:R-HSA-877300|refseq:XP_011546040.1|refseq:NP_001230894.1 - comment:P0DMV8,P0DMV9 - figure legend:6-1|comment:HLA-DRB1*0401;Inhibitor HLA-DRB1*1104|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/20 2020/10/15 - rogid:YdQX0KNIxO5tYjgm6hdRRZfNlk49606 - false - biotin tag:?-? - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation) intact:EBI-11820565 uniprotkb:P01911 - intact:EBI-1033104|uniprotkb:O19717|uniprotkb:O19739|uniprotkb:P13759|uniprotkb:Q29875|uniprotkb:Q30145|uniprotkb:Q9GIX9|uniprotkb:Q9GIY4|uniprotkb:Q9MY13|uniprotkb:Q9XRY5|uniprotkb:Q0PQ39|uniprotkb:Q14280|uniprotkb:Q14QT2|uniprotkb:Q155F7|uniprotkb:Q19AF2|uniprotkb:Q19K86|uniprotkb:Q1AP33|uniprotkb:Q1G0Z9|uniprotkb:Q1JRP3|uniprotkb:Q1KLJ6|uniprotkb:Q27PR6|uniprotkb:Q27PR7|uniprotkb:Q29673|uniprotkb:Q29720|uniprotkb:Q29722|uniprotkb:Q29734|uniprotkb:Q29770|uniprotkb:Q29771|uniprotkb:A0MWF2|uniprotkb:A0N0W1|uniprotkb:A2ICT1|uniprotkb:A2TGX3|uniprotkb:A4F5N0|uniprotkb:A4ZXA5|uniprotkb:A4ZXA6|uniprotkb:A4ZY86|uniprotkb:A5H000|ensembl:ENSP00000353099|uniprotkb:A5HKN8|uniprotkb:A7DZP9|uniprotkb:A7LA26|uniprotkb:A7UHG2|uniprotkb:A7X5B1|uniprotkb:A7X5B7|uniprotkb:A7X5E0|uniprotkb:A7X5E6|uniprotkb:A7X5H8|uniprotkb:A7X5J4|uniprotkb:A7X5K7|uniprotkb:A8K098|uniprotkb:A8YQE9|uniprotkb:A9JPG0|uniprotkb:B0BK85|uniprotkb:B1GWE7|uniprotkb:B2CR03|uniprotkb:B0LUZ6|uniprotkb:B0UYW1|uniprotkb:Q768U2|uniprotkb:Q29772|uniprotkb:Q29790|uniprotkb:Q29792|uniprotkb:Q29800|uniprotkb:Q29806|uniprotkb:Q29833|uniprotkb:Q29874|uniprotkb:Q29886|uniprotkb:Q29968|uniprotkb:Q29974|uniprotkb:Q29975|uniprotkb:Q2A120|uniprotkb:Q2HZE5|uniprotkb:Q2L9H4|uniprotkb:Q2LE76|uniprotkb:Q2MF40|uniprotkb:Q2MJA6|uniprotkb:Q2MZ92|uniprotkb:Q2VQU1|uniprotkb:Q2YHQ2|uniprotkb:Q30006|uniprotkb:Q30108|uniprotkb:Q30112|uniprotkb:Q30115|uniprotkb:Q30116|uniprotkb:Q30117|uniprotkb:Q30120|uniprotkb:Q30134|uniprotkb:Q30142|uniprotkb:Q30149|uniprotkb:Q30159|uniprotkb:Q30166|uniprotkb:Q30167|uniprotkb:Q30200|uniprotkb:Q307W5|uniprotkb:Q31636|uniprotkb:Q32MY7|uniprotkb:Q3HUP9|uniprotkb:Q3KTM1|uniprotkb:Q3LA84|uniprotkb:Q3LA87|uniprotkb:Q3LA88|uniprotkb:Q3LA89|uniprotkb:Q3LA90|uniprotkb:Q3LA91|uniprotkb:Q3LA92|uniprotkb:Q3LA93|uniprotkb:Q3LA94|uniprotkb:Q3LA95|uniprotkb:Q3LA96|uniprotkb:Q3LA97|uniprotkb:Q3LA98|uniprotkb:Q3LA99|uniprotkb:Q3LAA0|uniprotkb:Q3LAA1|uniprotkb:Q3LAA2|uniprotkb:Q3MQ60|uniprotkb:Q3T919|uniprotkb:Q4PRC3|uniprotkb:Q4PRC5|uniprotkb:Q4VZY7|uniprotkb:Q53IG1|uniprotkb:Q56FN9|uniprotkb:Q56FP1|uniprotkb:Q56FP2|uniprotkb:Q56FP3|uniprotkb:Q58F52|uniprotkb:Q5BM92|uniprotkb:Q5EER6|uniprotkb:Q5K3W2|uniprotkb:Q5NDB9|uniprotkb:Q5U9W6|uniprotkb:Q5UBA2|uniprotkb:Q5UT58|uniprotkb:Q5W3L4|uniprotkb:Q5Y7A7|uniprotkb:Q5Y7B0|uniprotkb:Q5Y7B9|uniprotkb:Q5Y7E9|uniprotkb:Q5Y7G0|uniprotkb:Q683P7|uniprotkb:Q6REE2|uniprotkb:Q6T865|uniprotkb:Q6U387|uniprotkb:Q701T1|uniprotkb:Q70GL2|uniprotkb:Q70Q85|uniprotkb:Q768U4|uniprotkb:Q7M2H4|uniprotkb:Q7YNY9|uniprotkb:Q7YP03|uniprotkb:Q7YP04|uniprotkb:Q7YQ26|uniprotkb:Q7YQA3|uniprotkb:Q7YQA5|uniprotkb:Q860D8|uniprotkb:Q860D9|uniprotkb:Q860E5|uniprotkb:Q860H8|uniprotkb:Q860S0|uniprotkb:Q860Z3|uniprotkb:Q861G6|uniprotkb:Q861H0|uniprotkb:Q861H4|uniprotkb:Q861H5|uniprotkb:Q861H7|uniprotkb:Q861H8|uniprotkb:Q8HWQ6|uniprotkb:Q8MH59|uniprotkb:Q8MH60|uniprotkb:Q8WLU3|uniprotkb:Q8WMA0|uniprotkb:Q95348|uniprotkb:Q95383|uniprotkb:Q95389|uniprotkb:Q95461|uniprotkb:Q95HK1|uniprotkb:Q95HL0|uniprotkb:Q95HL1|uniprotkb:Q95IE3|uniprotkb:Q95IG2|uniprotkb:Q95IT6|uniprotkb:Q96HZ9|uniprotkb:Q9BCL7|uniprotkb:Q9BCP0|uniprotkb:Q9BCP1|uniprotkb:Q9BCP2|uniprotkb:Q9BCP5|uniprotkb:Q9BD21|uniprotkb:Q9BD33|uniprotkb:Q9BD40|uniprotkb:Q9GIK5|uniprotkb:Q9GIL5|uniprotkb:Q9GIL6|uniprotkb:Q9GIP3|uniprotkb:Q9GIX8|uniprotkb:Q9GIY0|uniprotkb:Q9GIY1|uniprotkb:Q9GIY2|uniprotkb:B2LVF9|uniprotkb:B2NJ29|uniprotkb:B2ZCY1|uniprotkb:B3VTP8|uniprotkb:B3VTQ3|uniprotkb:B5A8Y2|uniprotkb:B5A8Y3|uniprotkb:C0LAB5|uniprotkb:B5B8U0|uniprotkb:B5B9V5|uniprotkb:B5B9V6|uniprotkb:B5LZ25|uniprotkb:B5QSK8|uniprotkb:B6VCX2|uniprotkb:B6VEL9|uniprotkb:B7UDB2|uniprotkb:B9VRA4|uniprotkb:B9X248|uniprotkb:Q0PGR5|uniprotkb:O02876|uniprotkb:O02930|uniprotkb:O19585|uniprotkb:O19718|uniprotkb:O19788|uniprotkb:O46699|uniprotkb:O46793|uniprotkb:O46872|uniprotkb:O62869|uniprotkb:O62889|uniprotkb:O77969|uniprotkb:O78047|uniprotkb:O78210|uniprotkb:O98212|uniprotkb:P01912|uniprotkb:P01914|uniprotkb:P04229|uniprotkb:P13758|uniprotkb:P13760|uniprotkb:P13761|uniprotkb:P20039|uniprotkb:P79545|uniprotkb:Q06662|intact:EBI-3866098|intact:EBI-13953066|uniprotkb:Q9GIY3|uniprotkb:Q9GJ25|uniprotkb:Q9GJ56|uniprotkb:Q9GJ57|uniprotkb:Q9GJ58|uniprotkb:Q9GJ60|uniprotkb:Q9GJF8|uniprotkb:Q9GJF9|uniprotkb:Q9GJG0|uniprotkb:Q9MXZ0|uniprotkb:Q9MXZ5|uniprotkb:Q9MY45|uniprotkb:Q9MY56|uniprotkb:Q9MYF5|uniprotkb:Q9TPB6|uniprotkb:Q9TPW1|uniprotkb:Q9TPW3|uniprotkb:Q9TPW9|uniprotkb:Q9TPX4|uniprotkb:Q9TQ37|uniprotkb:Q9TQ91|uniprotkb:Q9TQE0|uniprotkb:Q9UBY1|uniprotkb:Q9UIM9|uniprotkb:Q9UIN0|uniprotkb:Q9XRX1|uniprotkb:Q9XRY4|uniprotkb:Q9Y453|uniprotkb:Q9Y4H7|intact:EBI-13953170|intact:EBI-2877159 psi-mi:hspa1a_hspa1b_human-1(display_short)|psi-mi:EBI-11820565(display_long) psi-mi:drb1_human(display_long)|uniprotkb:HLA-DRB1(gene name)|psi-mi:HLA-DRB1(display_short)|uniprotkb:Human leukocyte antigen DRB1(gene name synonym) psi-mi:"MI:0892"(solid phase assay) Haug et al. (2007) imex:IM-25683|pubmed:17357109 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13953043|imex:IM-25683-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0586"(inhibitor) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:1304"(molecule set) psi-mi:"MI:0326"(protein) - refseq:NP_002115.2|ensembl:ENSG00000196126(gene)|ensembl:ENST00000360004(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001772"(immunological synapse)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0002469"(myeloid dendritic cell antigen processing and presentation)|go:"GO:0002491"(antigen processing and presentation of endogenous peptide antigen via MHC class II)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0002842"(positive regulation of T cell mediated immune response to tumor cell)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005615"(extracellular space)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0008544"(epidermis development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016045"(detection of bacterium)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030247"(polysaccharide binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032395"(MHC class II receptor activity)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032653"(regulation of interleukin-10 production)|go:"GO:0032673"(regulation of interleukin-4 production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032831"(positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043382"(positive regulation of memory T cell differentiation)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045622"(regulation of T-helper cell differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046598"(positive regulation of viral entry into host cell)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2000516"(positive regulation of CD4-positive, alpha-beta T cell activation)|interpro:IPR000353(MHC class II, beta chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1A6A|rcsb pdb:1AQD|rcsb pdb:1BX2|rcsb pdb:1D5M|rcsb pdb:1D5X|rcsb pdb:1D5Z|rcsb pdb:1D6E|rcsb pdb:1DLH|rcsb pdb:1FYT|rcsb pdb:1HXY|rcsb pdb:1J8H|rcsb pdb:1JWM|rcsb pdb:1JWS|rcsb pdb:1JWU|rcsb pdb:1KG0|rcsb pdb:1KLG|rcsb pdb:1KLU|rcsb pdb:1LO5|rcsb pdb:1PYW|rcsb pdb:1R5I|rcsb pdb:1SEB|rcsb pdb:1SJE|rcsb pdb:1SJH|rcsb pdb:1T5W|rcsb pdb:1T5X|rcsb pdb:1YMM|rcsb pdb:2FSE|rcsb pdb:2G9H|rcsb pdb:2IAM|rcsb pdb:2IAN|rcsb pdb:2ICW|rcsb pdb:2IPK|rcsb pdb:2OJE|rcsb pdb:2SEB|rcsb pdb:2WBJ|rcsb pdb:2XN9|rcsb pdb:3L6F|rcsb pdb:3O6F|rcsb pdb:3PDO|rcsb pdb:3PGC|rcsb pdb:3PGD|rcsb pdb:3QXA|rcsb pdb:3QXD|rcsb pdb:3S4S|rcsb pdb:3S5L|rcsb pdb:3T0E|rcsb pdb:4AEN|rcsb pdb:4AH2|rcsb pdb:4C56|rcsb pdb:4E41|rcsb pdb:4FQX|rcsb pdb:4GBX|rcsb pdb:4I5B|rcsb pdb:4IS6|rcsb pdb:4MCY|rcsb pdb:4MCZ|rcsb pdb:4MD0|rcsb pdb:4MD4|rcsb pdb:4MD5|rcsb pdb:4MDI|rcsb pdb:4MDJ|rcsb pdb:4OV5|rcsb pdb:4X5W|rcsb pdb:4X5X|rcsb pdb:4Y19|rcsb pdb:4Y1A|rcsb pdb:5JLZ|rcsb pdb:5LAX|rcsb pdb:5NI9|rcsb pdb:5NIG|rcsb pdb:6BIJ|rcsb pdb:6BIL|rcsb pdb:6BIN|rcsb pdb:6BIR|rcsb pdb:6BIV|rcsb pdb:6BIX|rcsb pdb:6BIY|rcsb pdb:6BIZ|rcsb pdb:6CPL|rcsb pdb:6CPN|rcsb pdb:6CPO|rcsb pdb:6CQJ|rcsb pdb:6CQL|rcsb pdb:6CQN|rcsb pdb:6CQQ|rcsb pdb:6CQR|rcsb pdb:6HBY|rcsb pdb:6NIX|rcsb pdb:6QZA|rcsb pdb:6QZC|rcsb pdb:6QZD|rcsb pdb:6R0E|rcsb pdb:6V0Y|rcsb pdb:6V13|rcsb pdb:6V15|rcsb pdb:6V18|rcsb pdb:6V19|rcsb pdb:6V1A|reactome:R-HSA-202424|reactome:R-HSA-202427|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-2132295|reactome:R-HSA-389948|reactome:R-HSA-877300|refseq:XP_011546040.1|refseq:NP_001230894.1 - comment:P0DMV8,P0DMV9 - figure legend:6-2|comment:HLA-DRB1*0401;Inhibitor HLA-DRB1*0801|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/20 2020/10/15 - rogid:YdQX0KNIxO5tYjgm6hdRRZfNlk49606 - false - - - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation) intact:EBI-11820565 uniprotkb:P01911 - intact:EBI-1033104|uniprotkb:O19717|uniprotkb:O19739|uniprotkb:P13759|uniprotkb:Q29875|uniprotkb:Q30145|uniprotkb:Q9GIX9|uniprotkb:Q9GIY4|uniprotkb:Q9MY13|uniprotkb:Q9XRY5|uniprotkb:Q0PQ39|uniprotkb:Q14280|uniprotkb:Q14QT2|uniprotkb:Q155F7|uniprotkb:Q19AF2|uniprotkb:Q19K86|uniprotkb:Q1AP33|uniprotkb:Q1G0Z9|uniprotkb:Q1JRP3|uniprotkb:Q1KLJ6|uniprotkb:Q27PR6|uniprotkb:Q27PR7|uniprotkb:Q29673|uniprotkb:Q29720|uniprotkb:Q29722|uniprotkb:Q29734|uniprotkb:Q29770|uniprotkb:Q29771|uniprotkb:A0MWF2|uniprotkb:A0N0W1|uniprotkb:A2ICT1|uniprotkb:A2TGX3|uniprotkb:A4F5N0|uniprotkb:A4ZXA5|uniprotkb:A4ZXA6|uniprotkb:A4ZY86|uniprotkb:A5H000|ensembl:ENSP00000353099|uniprotkb:A5HKN8|uniprotkb:A7DZP9|uniprotkb:A7LA26|uniprotkb:A7UHG2|uniprotkb:A7X5B1|uniprotkb:A7X5B7|uniprotkb:A7X5E0|uniprotkb:A7X5E6|uniprotkb:A7X5H8|uniprotkb:A7X5J4|uniprotkb:A7X5K7|uniprotkb:A8K098|uniprotkb:A8YQE9|uniprotkb:A9JPG0|uniprotkb:B0BK85|uniprotkb:B1GWE7|uniprotkb:B2CR03|uniprotkb:B0LUZ6|uniprotkb:B0UYW1|uniprotkb:Q768U2|uniprotkb:Q29772|uniprotkb:Q29790|uniprotkb:Q29792|uniprotkb:Q29800|uniprotkb:Q29806|uniprotkb:Q29833|uniprotkb:Q29874|uniprotkb:Q29886|uniprotkb:Q29968|uniprotkb:Q29974|uniprotkb:Q29975|uniprotkb:Q2A120|uniprotkb:Q2HZE5|uniprotkb:Q2L9H4|uniprotkb:Q2LE76|uniprotkb:Q2MF40|uniprotkb:Q2MJA6|uniprotkb:Q2MZ92|uniprotkb:Q2VQU1|uniprotkb:Q2YHQ2|uniprotkb:Q30006|uniprotkb:Q30108|uniprotkb:Q30112|uniprotkb:Q30115|uniprotkb:Q30116|uniprotkb:Q30117|uniprotkb:Q30120|uniprotkb:Q30134|uniprotkb:Q30142|uniprotkb:Q30149|uniprotkb:Q30159|uniprotkb:Q30166|uniprotkb:Q30167|uniprotkb:Q30200|uniprotkb:Q307W5|uniprotkb:Q31636|uniprotkb:Q32MY7|uniprotkb:Q3HUP9|uniprotkb:Q3KTM1|uniprotkb:Q3LA84|uniprotkb:Q3LA87|uniprotkb:Q3LA88|uniprotkb:Q3LA89|uniprotkb:Q3LA90|uniprotkb:Q3LA91|uniprotkb:Q3LA92|uniprotkb:Q3LA93|uniprotkb:Q3LA94|uniprotkb:Q3LA95|uniprotkb:Q3LA96|uniprotkb:Q3LA97|uniprotkb:Q3LA98|uniprotkb:Q3LA99|uniprotkb:Q3LAA0|uniprotkb:Q3LAA1|uniprotkb:Q3LAA2|uniprotkb:Q3MQ60|uniprotkb:Q3T919|uniprotkb:Q4PRC3|uniprotkb:Q4PRC5|uniprotkb:Q4VZY7|uniprotkb:Q53IG1|uniprotkb:Q56FN9|uniprotkb:Q56FP1|uniprotkb:Q56FP2|uniprotkb:Q56FP3|uniprotkb:Q58F52|uniprotkb:Q5BM92|uniprotkb:Q5EER6|uniprotkb:Q5K3W2|uniprotkb:Q5NDB9|uniprotkb:Q5U9W6|uniprotkb:Q5UBA2|uniprotkb:Q5UT58|uniprotkb:Q5W3L4|uniprotkb:Q5Y7A7|uniprotkb:Q5Y7B0|uniprotkb:Q5Y7B9|uniprotkb:Q5Y7E9|uniprotkb:Q5Y7G0|uniprotkb:Q683P7|uniprotkb:Q6REE2|uniprotkb:Q6T865|uniprotkb:Q6U387|uniprotkb:Q701T1|uniprotkb:Q70GL2|uniprotkb:Q70Q85|uniprotkb:Q768U4|uniprotkb:Q7M2H4|uniprotkb:Q7YNY9|uniprotkb:Q7YP03|uniprotkb:Q7YP04|uniprotkb:Q7YQ26|uniprotkb:Q7YQA3|uniprotkb:Q7YQA5|uniprotkb:Q860D8|uniprotkb:Q860D9|uniprotkb:Q860E5|uniprotkb:Q860H8|uniprotkb:Q860S0|uniprotkb:Q860Z3|uniprotkb:Q861G6|uniprotkb:Q861H0|uniprotkb:Q861H4|uniprotkb:Q861H5|uniprotkb:Q861H7|uniprotkb:Q861H8|uniprotkb:Q8HWQ6|uniprotkb:Q8MH59|uniprotkb:Q8MH60|uniprotkb:Q8WLU3|uniprotkb:Q8WMA0|uniprotkb:Q95348|uniprotkb:Q95383|uniprotkb:Q95389|uniprotkb:Q95461|uniprotkb:Q95HK1|uniprotkb:Q95HL0|uniprotkb:Q95HL1|uniprotkb:Q95IE3|uniprotkb:Q95IG2|uniprotkb:Q95IT6|uniprotkb:Q96HZ9|uniprotkb:Q9BCL7|uniprotkb:Q9BCP0|uniprotkb:Q9BCP1|uniprotkb:Q9BCP2|uniprotkb:Q9BCP5|uniprotkb:Q9BD21|uniprotkb:Q9BD33|uniprotkb:Q9BD40|uniprotkb:Q9GIK5|uniprotkb:Q9GIL5|uniprotkb:Q9GIL6|uniprotkb:Q9GIP3|uniprotkb:Q9GIX8|uniprotkb:Q9GIY0|uniprotkb:Q9GIY1|uniprotkb:Q9GIY2|uniprotkb:B2LVF9|uniprotkb:B2NJ29|uniprotkb:B2ZCY1|uniprotkb:B3VTP8|uniprotkb:B3VTQ3|uniprotkb:B5A8Y2|uniprotkb:B5A8Y3|uniprotkb:C0LAB5|uniprotkb:B5B8U0|uniprotkb:B5B9V5|uniprotkb:B5B9V6|uniprotkb:B5LZ25|uniprotkb:B5QSK8|uniprotkb:B6VCX2|uniprotkb:B6VEL9|uniprotkb:B7UDB2|uniprotkb:B9VRA4|uniprotkb:B9X248|uniprotkb:Q0PGR5|uniprotkb:O02876|uniprotkb:O02930|uniprotkb:O19585|uniprotkb:O19718|uniprotkb:O19788|uniprotkb:O46699|uniprotkb:O46793|uniprotkb:O46872|uniprotkb:O62869|uniprotkb:O62889|uniprotkb:O77969|uniprotkb:O78047|uniprotkb:O78210|uniprotkb:O98212|uniprotkb:P01912|uniprotkb:P01914|uniprotkb:P04229|uniprotkb:P13758|uniprotkb:P13760|uniprotkb:P13761|uniprotkb:P20039|uniprotkb:P79545|uniprotkb:Q06662|intact:EBI-3866098|intact:EBI-13953066|uniprotkb:Q9GIY3|uniprotkb:Q9GJ25|uniprotkb:Q9GJ56|uniprotkb:Q9GJ57|uniprotkb:Q9GJ58|uniprotkb:Q9GJ60|uniprotkb:Q9GJF8|uniprotkb:Q9GJF9|uniprotkb:Q9GJG0|uniprotkb:Q9MXZ0|uniprotkb:Q9MXZ5|uniprotkb:Q9MY45|uniprotkb:Q9MY56|uniprotkb:Q9MYF5|uniprotkb:Q9TPB6|uniprotkb:Q9TPW1|uniprotkb:Q9TPW3|uniprotkb:Q9TPW9|uniprotkb:Q9TPX4|uniprotkb:Q9TQ37|uniprotkb:Q9TQ91|uniprotkb:Q9TQE0|uniprotkb:Q9UBY1|uniprotkb:Q9UIM9|uniprotkb:Q9UIN0|uniprotkb:Q9XRX1|uniprotkb:Q9XRY4|uniprotkb:Q9Y453|uniprotkb:Q9Y4H7|intact:EBI-13953170|intact:EBI-2877159 psi-mi:hspa1a_hspa1b_human-1(display_short)|psi-mi:EBI-11820565(display_long) psi-mi:drb1_human(display_long)|uniprotkb:HLA-DRB1(gene name)|psi-mi:HLA-DRB1(display_short)|uniprotkb:Human leukocyte antigen DRB1(gene name synonym) psi-mi:"MI:0892"(solid phase assay) Haug et al. (2007) imex:IM-25683|pubmed:17357109 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13953043|imex:IM-25683-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:1304"(molecule set) psi-mi:"MI:0326"(protein) - refseq:NP_002115.2|ensembl:ENSG00000196126(gene)|ensembl:ENST00000360004(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001772"(immunological synapse)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0002469"(myeloid dendritic cell antigen processing and presentation)|go:"GO:0002491"(antigen processing and presentation of endogenous peptide antigen via MHC class II)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0002842"(positive regulation of T cell mediated immune response to tumor cell)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005615"(extracellular space)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0008544"(epidermis development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016045"(detection of bacterium)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030247"(polysaccharide binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032395"(MHC class II receptor activity)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032653"(regulation of interleukin-10 production)|go:"GO:0032673"(regulation of interleukin-4 production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032831"(positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043382"(positive regulation of memory T cell differentiation)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045622"(regulation of T-helper cell differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046598"(positive regulation of viral entry into host cell)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2000516"(positive regulation of CD4-positive, alpha-beta T cell activation)|interpro:IPR000353(MHC class II, beta chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1A6A|rcsb pdb:1AQD|rcsb pdb:1BX2|rcsb pdb:1D5M|rcsb pdb:1D5X|rcsb pdb:1D5Z|rcsb pdb:1D6E|rcsb pdb:1DLH|rcsb pdb:1FYT|rcsb pdb:1HXY|rcsb pdb:1J8H|rcsb pdb:1JWM|rcsb pdb:1JWS|rcsb pdb:1JWU|rcsb pdb:1KG0|rcsb pdb:1KLG|rcsb pdb:1KLU|rcsb pdb:1LO5|rcsb pdb:1PYW|rcsb pdb:1R5I|rcsb pdb:1SEB|rcsb pdb:1SJE|rcsb pdb:1SJH|rcsb pdb:1T5W|rcsb pdb:1T5X|rcsb pdb:1YMM|rcsb pdb:2FSE|rcsb pdb:2G9H|rcsb pdb:2IAM|rcsb pdb:2IAN|rcsb pdb:2ICW|rcsb pdb:2IPK|rcsb pdb:2OJE|rcsb pdb:2SEB|rcsb pdb:2WBJ|rcsb pdb:2XN9|rcsb pdb:3L6F|rcsb pdb:3O6F|rcsb pdb:3PDO|rcsb pdb:3PGC|rcsb pdb:3PGD|rcsb pdb:3QXA|rcsb pdb:3QXD|rcsb pdb:3S4S|rcsb pdb:3S5L|rcsb pdb:3T0E|rcsb pdb:4AEN|rcsb pdb:4AH2|rcsb pdb:4C56|rcsb pdb:4E41|rcsb pdb:4FQX|rcsb pdb:4GBX|rcsb pdb:4I5B|rcsb pdb:4IS6|rcsb pdb:4MCY|rcsb pdb:4MCZ|rcsb pdb:4MD0|rcsb pdb:4MD4|rcsb pdb:4MD5|rcsb pdb:4MDI|rcsb pdb:4MDJ|rcsb pdb:4OV5|rcsb pdb:4X5W|rcsb pdb:4X5X|rcsb pdb:4Y19|rcsb pdb:4Y1A|rcsb pdb:5JLZ|rcsb pdb:5LAX|rcsb pdb:5NI9|rcsb pdb:5NIG|rcsb pdb:6BIJ|rcsb pdb:6BIL|rcsb pdb:6BIN|rcsb pdb:6BIR|rcsb pdb:6BIV|rcsb pdb:6BIX|rcsb pdb:6BIY|rcsb pdb:6BIZ|rcsb pdb:6CPL|rcsb pdb:6CPN|rcsb pdb:6CPO|rcsb pdb:6CQJ|rcsb pdb:6CQL|rcsb pdb:6CQN|rcsb pdb:6CQQ|rcsb pdb:6CQR|rcsb pdb:6HBY|rcsb pdb:6NIX|rcsb pdb:6QZA|rcsb pdb:6QZC|rcsb pdb:6QZD|rcsb pdb:6R0E|rcsb pdb:6V0Y|rcsb pdb:6V13|rcsb pdb:6V15|rcsb pdb:6V18|rcsb pdb:6V19|rcsb pdb:6V1A|reactome:R-HSA-202424|reactome:R-HSA-202427|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-2132295|reactome:R-HSA-389948|reactome:R-HSA-877300|refseq:XP_011546040.1|refseq:NP_001230894.1 - comment:P0DMV8,P0DMV9 - figure legend:6-2|comment:HLA-DRB1*0401;Inhibitor HLA-DRB1*0801|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/20 2020/10/15 - rogid:YdQX0KNIxO5tYjgm6hdRRZfNlk49606 - false - biotin tag:?-? - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation) intact:EBI-11820565 uniprotkb:P01911 - intact:EBI-1033104|uniprotkb:O19717|uniprotkb:O19739|uniprotkb:P13759|uniprotkb:Q29875|uniprotkb:Q30145|uniprotkb:Q9GIX9|uniprotkb:Q9GIY4|uniprotkb:Q9MY13|uniprotkb:Q9XRY5|uniprotkb:Q0PQ39|uniprotkb:Q14280|uniprotkb:Q14QT2|uniprotkb:Q155F7|uniprotkb:Q19AF2|uniprotkb:Q19K86|uniprotkb:Q1AP33|uniprotkb:Q1G0Z9|uniprotkb:Q1JRP3|uniprotkb:Q1KLJ6|uniprotkb:Q27PR6|uniprotkb:Q27PR7|uniprotkb:Q29673|uniprotkb:Q29720|uniprotkb:Q29722|uniprotkb:Q29734|uniprotkb:Q29770|uniprotkb:Q29771|uniprotkb:A0MWF2|uniprotkb:A0N0W1|uniprotkb:A2ICT1|uniprotkb:A2TGX3|uniprotkb:A4F5N0|uniprotkb:A4ZXA5|uniprotkb:A4ZXA6|uniprotkb:A4ZY86|uniprotkb:A5H000|ensembl:ENSP00000353099|uniprotkb:A5HKN8|uniprotkb:A7DZP9|uniprotkb:A7LA26|uniprotkb:A7UHG2|uniprotkb:A7X5B1|uniprotkb:A7X5B7|uniprotkb:A7X5E0|uniprotkb:A7X5E6|uniprotkb:A7X5H8|uniprotkb:A7X5J4|uniprotkb:A7X5K7|uniprotkb:A8K098|uniprotkb:A8YQE9|uniprotkb:A9JPG0|uniprotkb:B0BK85|uniprotkb:B1GWE7|uniprotkb:B2CR03|uniprotkb:B0LUZ6|uniprotkb:B0UYW1|uniprotkb:Q768U2|uniprotkb:Q29772|uniprotkb:Q29790|uniprotkb:Q29792|uniprotkb:Q29800|uniprotkb:Q29806|uniprotkb:Q29833|uniprotkb:Q29874|uniprotkb:Q29886|uniprotkb:Q29968|uniprotkb:Q29974|uniprotkb:Q29975|uniprotkb:Q2A120|uniprotkb:Q2HZE5|uniprotkb:Q2L9H4|uniprotkb:Q2LE76|uniprotkb:Q2MF40|uniprotkb:Q2MJA6|uniprotkb:Q2MZ92|uniprotkb:Q2VQU1|uniprotkb:Q2YHQ2|uniprotkb:Q30006|uniprotkb:Q30108|uniprotkb:Q30112|uniprotkb:Q30115|uniprotkb:Q30116|uniprotkb:Q30117|uniprotkb:Q30120|uniprotkb:Q30134|uniprotkb:Q30142|uniprotkb:Q30149|uniprotkb:Q30159|uniprotkb:Q30166|uniprotkb:Q30167|uniprotkb:Q30200|uniprotkb:Q307W5|uniprotkb:Q31636|uniprotkb:Q32MY7|uniprotkb:Q3HUP9|uniprotkb:Q3KTM1|uniprotkb:Q3LA84|uniprotkb:Q3LA87|uniprotkb:Q3LA88|uniprotkb:Q3LA89|uniprotkb:Q3LA90|uniprotkb:Q3LA91|uniprotkb:Q3LA92|uniprotkb:Q3LA93|uniprotkb:Q3LA94|uniprotkb:Q3LA95|uniprotkb:Q3LA96|uniprotkb:Q3LA97|uniprotkb:Q3LA98|uniprotkb:Q3LA99|uniprotkb:Q3LAA0|uniprotkb:Q3LAA1|uniprotkb:Q3LAA2|uniprotkb:Q3MQ60|uniprotkb:Q3T919|uniprotkb:Q4PRC3|uniprotkb:Q4PRC5|uniprotkb:Q4VZY7|uniprotkb:Q53IG1|uniprotkb:Q56FN9|uniprotkb:Q56FP1|uniprotkb:Q56FP2|uniprotkb:Q56FP3|uniprotkb:Q58F52|uniprotkb:Q5BM92|uniprotkb:Q5EER6|uniprotkb:Q5K3W2|uniprotkb:Q5NDB9|uniprotkb:Q5U9W6|uniprotkb:Q5UBA2|uniprotkb:Q5UT58|uniprotkb:Q5W3L4|uniprotkb:Q5Y7A7|uniprotkb:Q5Y7B0|uniprotkb:Q5Y7B9|uniprotkb:Q5Y7E9|uniprotkb:Q5Y7G0|uniprotkb:Q683P7|uniprotkb:Q6REE2|uniprotkb:Q6T865|uniprotkb:Q6U387|uniprotkb:Q701T1|uniprotkb:Q70GL2|uniprotkb:Q70Q85|uniprotkb:Q768U4|uniprotkb:Q7M2H4|uniprotkb:Q7YNY9|uniprotkb:Q7YP03|uniprotkb:Q7YP04|uniprotkb:Q7YQ26|uniprotkb:Q7YQA3|uniprotkb:Q7YQA5|uniprotkb:Q860D8|uniprotkb:Q860D9|uniprotkb:Q860E5|uniprotkb:Q860H8|uniprotkb:Q860S0|uniprotkb:Q860Z3|uniprotkb:Q861G6|uniprotkb:Q861H0|uniprotkb:Q861H4|uniprotkb:Q861H5|uniprotkb:Q861H7|uniprotkb:Q861H8|uniprotkb:Q8HWQ6|uniprotkb:Q8MH59|uniprotkb:Q8MH60|uniprotkb:Q8WLU3|uniprotkb:Q8WMA0|uniprotkb:Q95348|uniprotkb:Q95383|uniprotkb:Q95389|uniprotkb:Q95461|uniprotkb:Q95HK1|uniprotkb:Q95HL0|uniprotkb:Q95HL1|uniprotkb:Q95IE3|uniprotkb:Q95IG2|uniprotkb:Q95IT6|uniprotkb:Q96HZ9|uniprotkb:Q9BCL7|uniprotkb:Q9BCP0|uniprotkb:Q9BCP1|uniprotkb:Q9BCP2|uniprotkb:Q9BCP5|uniprotkb:Q9BD21|uniprotkb:Q9BD33|uniprotkb:Q9BD40|uniprotkb:Q9GIK5|uniprotkb:Q9GIL5|uniprotkb:Q9GIL6|uniprotkb:Q9GIP3|uniprotkb:Q9GIX8|uniprotkb:Q9GIY0|uniprotkb:Q9GIY1|uniprotkb:Q9GIY2|uniprotkb:B2LVF9|uniprotkb:B2NJ29|uniprotkb:B2ZCY1|uniprotkb:B3VTP8|uniprotkb:B3VTQ3|uniprotkb:B5A8Y2|uniprotkb:B5A8Y3|uniprotkb:C0LAB5|uniprotkb:B5B8U0|uniprotkb:B5B9V5|uniprotkb:B5B9V6|uniprotkb:B5LZ25|uniprotkb:B5QSK8|uniprotkb:B6VCX2|uniprotkb:B6VEL9|uniprotkb:B7UDB2|uniprotkb:B9VRA4|uniprotkb:B9X248|uniprotkb:Q0PGR5|uniprotkb:O02876|uniprotkb:O02930|uniprotkb:O19585|uniprotkb:O19718|uniprotkb:O19788|uniprotkb:O46699|uniprotkb:O46793|uniprotkb:O46872|uniprotkb:O62869|uniprotkb:O62889|uniprotkb:O77969|uniprotkb:O78047|uniprotkb:O78210|uniprotkb:O98212|uniprotkb:P01912|uniprotkb:P01914|uniprotkb:P04229|uniprotkb:P13758|uniprotkb:P13760|uniprotkb:P13761|uniprotkb:P20039|uniprotkb:P79545|uniprotkb:Q06662|intact:EBI-3866098|intact:EBI-13953066|uniprotkb:Q9GIY3|uniprotkb:Q9GJ25|uniprotkb:Q9GJ56|uniprotkb:Q9GJ57|uniprotkb:Q9GJ58|uniprotkb:Q9GJ60|uniprotkb:Q9GJF8|uniprotkb:Q9GJF9|uniprotkb:Q9GJG0|uniprotkb:Q9MXZ0|uniprotkb:Q9MXZ5|uniprotkb:Q9MY45|uniprotkb:Q9MY56|uniprotkb:Q9MYF5|uniprotkb:Q9TPB6|uniprotkb:Q9TPW1|uniprotkb:Q9TPW3|uniprotkb:Q9TPW9|uniprotkb:Q9TPX4|uniprotkb:Q9TQ37|uniprotkb:Q9TQ91|uniprotkb:Q9TQE0|uniprotkb:Q9UBY1|uniprotkb:Q9UIM9|uniprotkb:Q9UIN0|uniprotkb:Q9XRX1|uniprotkb:Q9XRY4|uniprotkb:Q9Y453|uniprotkb:Q9Y4H7|intact:EBI-13953170|intact:EBI-2877159 psi-mi:hspa1a_hspa1b_human-1(display_short)|psi-mi:EBI-11820565(display_long) psi-mi:drb1_human(display_long)|uniprotkb:HLA-DRB1(gene name)|psi-mi:HLA-DRB1(display_short)|uniprotkb:Human leukocyte antigen DRB1(gene name synonym) psi-mi:"MI:0892"(solid phase assay) Haug et al. (2007) imex:IM-25683|pubmed:17357109 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13953058|imex:IM-25683-22 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0586"(inhibitor) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:1304"(molecule set) psi-mi:"MI:0326"(protein) - refseq:NP_002115.2|ensembl:ENSG00000196126(gene)|ensembl:ENST00000360004(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001772"(immunological synapse)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0002469"(myeloid dendritic cell antigen processing and presentation)|go:"GO:0002491"(antigen processing and presentation of endogenous peptide antigen via MHC class II)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0002842"(positive regulation of T cell mediated immune response to tumor cell)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005615"(extracellular space)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0008544"(epidermis development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016045"(detection of bacterium)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030247"(polysaccharide binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032395"(MHC class II receptor activity)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032653"(regulation of interleukin-10 production)|go:"GO:0032673"(regulation of interleukin-4 production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032831"(positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043382"(positive regulation of memory T cell differentiation)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045622"(regulation of T-helper cell differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046598"(positive regulation of viral entry into host cell)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2000516"(positive regulation of CD4-positive, alpha-beta T cell activation)|interpro:IPR000353(MHC class II, beta chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1A6A|rcsb pdb:1AQD|rcsb pdb:1BX2|rcsb pdb:1D5M|rcsb pdb:1D5X|rcsb pdb:1D5Z|rcsb pdb:1D6E|rcsb pdb:1DLH|rcsb pdb:1FYT|rcsb pdb:1HXY|rcsb pdb:1J8H|rcsb pdb:1JWM|rcsb pdb:1JWS|rcsb pdb:1JWU|rcsb pdb:1KG0|rcsb pdb:1KLG|rcsb pdb:1KLU|rcsb pdb:1LO5|rcsb pdb:1PYW|rcsb pdb:1R5I|rcsb pdb:1SEB|rcsb pdb:1SJE|rcsb pdb:1SJH|rcsb pdb:1T5W|rcsb pdb:1T5X|rcsb pdb:1YMM|rcsb pdb:2FSE|rcsb pdb:2G9H|rcsb pdb:2IAM|rcsb pdb:2IAN|rcsb pdb:2ICW|rcsb pdb:2IPK|rcsb pdb:2OJE|rcsb pdb:2SEB|rcsb pdb:2WBJ|rcsb pdb:2XN9|rcsb pdb:3L6F|rcsb pdb:3O6F|rcsb pdb:3PDO|rcsb pdb:3PGC|rcsb pdb:3PGD|rcsb pdb:3QXA|rcsb pdb:3QXD|rcsb pdb:3S4S|rcsb pdb:3S5L|rcsb pdb:3T0E|rcsb pdb:4AEN|rcsb pdb:4AH2|rcsb pdb:4C56|rcsb pdb:4E41|rcsb pdb:4FQX|rcsb pdb:4GBX|rcsb pdb:4I5B|rcsb pdb:4IS6|rcsb pdb:4MCY|rcsb pdb:4MCZ|rcsb pdb:4MD0|rcsb pdb:4MD4|rcsb pdb:4MD5|rcsb pdb:4MDI|rcsb pdb:4MDJ|rcsb pdb:4OV5|rcsb pdb:4X5W|rcsb pdb:4X5X|rcsb pdb:4Y19|rcsb pdb:4Y1A|rcsb pdb:5JLZ|rcsb pdb:5LAX|rcsb pdb:5NI9|rcsb pdb:5NIG|rcsb pdb:6BIJ|rcsb pdb:6BIL|rcsb pdb:6BIN|rcsb pdb:6BIR|rcsb pdb:6BIV|rcsb pdb:6BIX|rcsb pdb:6BIY|rcsb pdb:6BIZ|rcsb pdb:6CPL|rcsb pdb:6CPN|rcsb pdb:6CPO|rcsb pdb:6CQJ|rcsb pdb:6CQL|rcsb pdb:6CQN|rcsb pdb:6CQQ|rcsb pdb:6CQR|rcsb pdb:6HBY|rcsb pdb:6NIX|rcsb pdb:6QZA|rcsb pdb:6QZC|rcsb pdb:6QZD|rcsb pdb:6R0E|rcsb pdb:6V0Y|rcsb pdb:6V13|rcsb pdb:6V15|rcsb pdb:6V18|rcsb pdb:6V19|rcsb pdb:6V1A|reactome:R-HSA-202424|reactome:R-HSA-202427|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-2132295|reactome:R-HSA-389948|reactome:R-HSA-877300|refseq:XP_011546040.1|refseq:NP_001230894.1 - comment:P0DMV8,P0DMV9 - figure legend:6-3|comment:HLA-DRB1*0401;Inhibitor HLA-DRB1*0701|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/20 2020/10/15 - rogid:YdQX0KNIxO5tYjgm6hdRRZfNlk49606 - false - - - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation) intact:EBI-11820565 uniprotkb:P01911 - intact:EBI-1033104|uniprotkb:O19717|uniprotkb:O19739|uniprotkb:P13759|uniprotkb:Q29875|uniprotkb:Q30145|uniprotkb:Q9GIX9|uniprotkb:Q9GIY4|uniprotkb:Q9MY13|uniprotkb:Q9XRY5|uniprotkb:Q0PQ39|uniprotkb:Q14280|uniprotkb:Q14QT2|uniprotkb:Q155F7|uniprotkb:Q19AF2|uniprotkb:Q19K86|uniprotkb:Q1AP33|uniprotkb:Q1G0Z9|uniprotkb:Q1JRP3|uniprotkb:Q1KLJ6|uniprotkb:Q27PR6|uniprotkb:Q27PR7|uniprotkb:Q29673|uniprotkb:Q29720|uniprotkb:Q29722|uniprotkb:Q29734|uniprotkb:Q29770|uniprotkb:Q29771|uniprotkb:A0MWF2|uniprotkb:A0N0W1|uniprotkb:A2ICT1|uniprotkb:A2TGX3|uniprotkb:A4F5N0|uniprotkb:A4ZXA5|uniprotkb:A4ZXA6|uniprotkb:A4ZY86|uniprotkb:A5H000|ensembl:ENSP00000353099|uniprotkb:A5HKN8|uniprotkb:A7DZP9|uniprotkb:A7LA26|uniprotkb:A7UHG2|uniprotkb:A7X5B1|uniprotkb:A7X5B7|uniprotkb:A7X5E0|uniprotkb:A7X5E6|uniprotkb:A7X5H8|uniprotkb:A7X5J4|uniprotkb:A7X5K7|uniprotkb:A8K098|uniprotkb:A8YQE9|uniprotkb:A9JPG0|uniprotkb:B0BK85|uniprotkb:B1GWE7|uniprotkb:B2CR03|uniprotkb:B0LUZ6|uniprotkb:B0UYW1|uniprotkb:Q768U2|uniprotkb:Q29772|uniprotkb:Q29790|uniprotkb:Q29792|uniprotkb:Q29800|uniprotkb:Q29806|uniprotkb:Q29833|uniprotkb:Q29874|uniprotkb:Q29886|uniprotkb:Q29968|uniprotkb:Q29974|uniprotkb:Q29975|uniprotkb:Q2A120|uniprotkb:Q2HZE5|uniprotkb:Q2L9H4|uniprotkb:Q2LE76|uniprotkb:Q2MF40|uniprotkb:Q2MJA6|uniprotkb:Q2MZ92|uniprotkb:Q2VQU1|uniprotkb:Q2YHQ2|uniprotkb:Q30006|uniprotkb:Q30108|uniprotkb:Q30112|uniprotkb:Q30115|uniprotkb:Q30116|uniprotkb:Q30117|uniprotkb:Q30120|uniprotkb:Q30134|uniprotkb:Q30142|uniprotkb:Q30149|uniprotkb:Q30159|uniprotkb:Q30166|uniprotkb:Q30167|uniprotkb:Q30200|uniprotkb:Q307W5|uniprotkb:Q31636|uniprotkb:Q32MY7|uniprotkb:Q3HUP9|uniprotkb:Q3KTM1|uniprotkb:Q3LA84|uniprotkb:Q3LA87|uniprotkb:Q3LA88|uniprotkb:Q3LA89|uniprotkb:Q3LA90|uniprotkb:Q3LA91|uniprotkb:Q3LA92|uniprotkb:Q3LA93|uniprotkb:Q3LA94|uniprotkb:Q3LA95|uniprotkb:Q3LA96|uniprotkb:Q3LA97|uniprotkb:Q3LA98|uniprotkb:Q3LA99|uniprotkb:Q3LAA0|uniprotkb:Q3LAA1|uniprotkb:Q3LAA2|uniprotkb:Q3MQ60|uniprotkb:Q3T919|uniprotkb:Q4PRC3|uniprotkb:Q4PRC5|uniprotkb:Q4VZY7|uniprotkb:Q53IG1|uniprotkb:Q56FN9|uniprotkb:Q56FP1|uniprotkb:Q56FP2|uniprotkb:Q56FP3|uniprotkb:Q58F52|uniprotkb:Q5BM92|uniprotkb:Q5EER6|uniprotkb:Q5K3W2|uniprotkb:Q5NDB9|uniprotkb:Q5U9W6|uniprotkb:Q5UBA2|uniprotkb:Q5UT58|uniprotkb:Q5W3L4|uniprotkb:Q5Y7A7|uniprotkb:Q5Y7B0|uniprotkb:Q5Y7B9|uniprotkb:Q5Y7E9|uniprotkb:Q5Y7G0|uniprotkb:Q683P7|uniprotkb:Q6REE2|uniprotkb:Q6T865|uniprotkb:Q6U387|uniprotkb:Q701T1|uniprotkb:Q70GL2|uniprotkb:Q70Q85|uniprotkb:Q768U4|uniprotkb:Q7M2H4|uniprotkb:Q7YNY9|uniprotkb:Q7YP03|uniprotkb:Q7YP04|uniprotkb:Q7YQ26|uniprotkb:Q7YQA3|uniprotkb:Q7YQA5|uniprotkb:Q860D8|uniprotkb:Q860D9|uniprotkb:Q860E5|uniprotkb:Q860H8|uniprotkb:Q860S0|uniprotkb:Q860Z3|uniprotkb:Q861G6|uniprotkb:Q861H0|uniprotkb:Q861H4|uniprotkb:Q861H5|uniprotkb:Q861H7|uniprotkb:Q861H8|uniprotkb:Q8HWQ6|uniprotkb:Q8MH59|uniprotkb:Q8MH60|uniprotkb:Q8WLU3|uniprotkb:Q8WMA0|uniprotkb:Q95348|uniprotkb:Q95383|uniprotkb:Q95389|uniprotkb:Q95461|uniprotkb:Q95HK1|uniprotkb:Q95HL0|uniprotkb:Q95HL1|uniprotkb:Q95IE3|uniprotkb:Q95IG2|uniprotkb:Q95IT6|uniprotkb:Q96HZ9|uniprotkb:Q9BCL7|uniprotkb:Q9BCP0|uniprotkb:Q9BCP1|uniprotkb:Q9BCP2|uniprotkb:Q9BCP5|uniprotkb:Q9BD21|uniprotkb:Q9BD33|uniprotkb:Q9BD40|uniprotkb:Q9GIK5|uniprotkb:Q9GIL5|uniprotkb:Q9GIL6|uniprotkb:Q9GIP3|uniprotkb:Q9GIX8|uniprotkb:Q9GIY0|uniprotkb:Q9GIY1|uniprotkb:Q9GIY2|uniprotkb:B2LVF9|uniprotkb:B2NJ29|uniprotkb:B2ZCY1|uniprotkb:B3VTP8|uniprotkb:B3VTQ3|uniprotkb:B5A8Y2|uniprotkb:B5A8Y3|uniprotkb:C0LAB5|uniprotkb:B5B8U0|uniprotkb:B5B9V5|uniprotkb:B5B9V6|uniprotkb:B5LZ25|uniprotkb:B5QSK8|uniprotkb:B6VCX2|uniprotkb:B6VEL9|uniprotkb:B7UDB2|uniprotkb:B9VRA4|uniprotkb:B9X248|uniprotkb:Q0PGR5|uniprotkb:O02876|uniprotkb:O02930|uniprotkb:O19585|uniprotkb:O19718|uniprotkb:O19788|uniprotkb:O46699|uniprotkb:O46793|uniprotkb:O46872|uniprotkb:O62869|uniprotkb:O62889|uniprotkb:O77969|uniprotkb:O78047|uniprotkb:O78210|uniprotkb:O98212|uniprotkb:P01912|uniprotkb:P01914|uniprotkb:P04229|uniprotkb:P13758|uniprotkb:P13760|uniprotkb:P13761|uniprotkb:P20039|uniprotkb:P79545|uniprotkb:Q06662|intact:EBI-3866098|intact:EBI-13953066|uniprotkb:Q9GIY3|uniprotkb:Q9GJ25|uniprotkb:Q9GJ56|uniprotkb:Q9GJ57|uniprotkb:Q9GJ58|uniprotkb:Q9GJ60|uniprotkb:Q9GJF8|uniprotkb:Q9GJF9|uniprotkb:Q9GJG0|uniprotkb:Q9MXZ0|uniprotkb:Q9MXZ5|uniprotkb:Q9MY45|uniprotkb:Q9MY56|uniprotkb:Q9MYF5|uniprotkb:Q9TPB6|uniprotkb:Q9TPW1|uniprotkb:Q9TPW3|uniprotkb:Q9TPW9|uniprotkb:Q9TPX4|uniprotkb:Q9TQ37|uniprotkb:Q9TQ91|uniprotkb:Q9TQE0|uniprotkb:Q9UBY1|uniprotkb:Q9UIM9|uniprotkb:Q9UIN0|uniprotkb:Q9XRX1|uniprotkb:Q9XRY4|uniprotkb:Q9Y453|uniprotkb:Q9Y4H7|intact:EBI-13953170|intact:EBI-2877159 psi-mi:hspa1a_hspa1b_human-1(display_short)|psi-mi:EBI-11820565(display_long) psi-mi:drb1_human(display_long)|uniprotkb:HLA-DRB1(gene name)|psi-mi:HLA-DRB1(display_short)|uniprotkb:Human leukocyte antigen DRB1(gene name synonym) psi-mi:"MI:0892"(solid phase assay) Haug et al. (2007) imex:IM-25683|pubmed:17357109 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13953058|imex:IM-25683-22 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:1304"(molecule set) psi-mi:"MI:0326"(protein) - refseq:NP_002115.2|ensembl:ENSG00000196126(gene)|ensembl:ENST00000360004(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001772"(immunological synapse)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0002469"(myeloid dendritic cell antigen processing and presentation)|go:"GO:0002491"(antigen processing and presentation of endogenous peptide antigen via MHC class II)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0002842"(positive regulation of T cell mediated immune response to tumor cell)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005615"(extracellular space)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0008544"(epidermis development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016045"(detection of bacterium)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030247"(polysaccharide binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032395"(MHC class II receptor activity)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032653"(regulation of interleukin-10 production)|go:"GO:0032673"(regulation of interleukin-4 production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032831"(positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043382"(positive regulation of memory T cell differentiation)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045622"(regulation of T-helper cell differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046598"(positive regulation of viral entry into host cell)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2000516"(positive regulation of CD4-positive, alpha-beta T cell activation)|interpro:IPR000353(MHC class II, beta chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1A6A|rcsb pdb:1AQD|rcsb pdb:1BX2|rcsb pdb:1D5M|rcsb pdb:1D5X|rcsb pdb:1D5Z|rcsb pdb:1D6E|rcsb pdb:1DLH|rcsb pdb:1FYT|rcsb pdb:1HXY|rcsb pdb:1J8H|rcsb pdb:1JWM|rcsb pdb:1JWS|rcsb pdb:1JWU|rcsb pdb:1KG0|rcsb pdb:1KLG|rcsb pdb:1KLU|rcsb pdb:1LO5|rcsb pdb:1PYW|rcsb pdb:1R5I|rcsb pdb:1SEB|rcsb pdb:1SJE|rcsb pdb:1SJH|rcsb pdb:1T5W|rcsb pdb:1T5X|rcsb pdb:1YMM|rcsb pdb:2FSE|rcsb pdb:2G9H|rcsb pdb:2IAM|rcsb pdb:2IAN|rcsb pdb:2ICW|rcsb pdb:2IPK|rcsb pdb:2OJE|rcsb pdb:2SEB|rcsb pdb:2WBJ|rcsb pdb:2XN9|rcsb pdb:3L6F|rcsb pdb:3O6F|rcsb pdb:3PDO|rcsb pdb:3PGC|rcsb pdb:3PGD|rcsb pdb:3QXA|rcsb pdb:3QXD|rcsb pdb:3S4S|rcsb pdb:3S5L|rcsb pdb:3T0E|rcsb pdb:4AEN|rcsb pdb:4AH2|rcsb pdb:4C56|rcsb pdb:4E41|rcsb pdb:4FQX|rcsb pdb:4GBX|rcsb pdb:4I5B|rcsb pdb:4IS6|rcsb pdb:4MCY|rcsb pdb:4MCZ|rcsb pdb:4MD0|rcsb pdb:4MD4|rcsb pdb:4MD5|rcsb pdb:4MDI|rcsb pdb:4MDJ|rcsb pdb:4OV5|rcsb pdb:4X5W|rcsb pdb:4X5X|rcsb pdb:4Y19|rcsb pdb:4Y1A|rcsb pdb:5JLZ|rcsb pdb:5LAX|rcsb pdb:5NI9|rcsb pdb:5NIG|rcsb pdb:6BIJ|rcsb pdb:6BIL|rcsb pdb:6BIN|rcsb pdb:6BIR|rcsb pdb:6BIV|rcsb pdb:6BIX|rcsb pdb:6BIY|rcsb pdb:6BIZ|rcsb pdb:6CPL|rcsb pdb:6CPN|rcsb pdb:6CPO|rcsb pdb:6CQJ|rcsb pdb:6CQL|rcsb pdb:6CQN|rcsb pdb:6CQQ|rcsb pdb:6CQR|rcsb pdb:6HBY|rcsb pdb:6NIX|rcsb pdb:6QZA|rcsb pdb:6QZC|rcsb pdb:6QZD|rcsb pdb:6R0E|rcsb pdb:6V0Y|rcsb pdb:6V13|rcsb pdb:6V15|rcsb pdb:6V18|rcsb pdb:6V19|rcsb pdb:6V1A|reactome:R-HSA-202424|reactome:R-HSA-202427|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-2132295|reactome:R-HSA-389948|reactome:R-HSA-877300|refseq:XP_011546040.1|refseq:NP_001230894.1 - comment:P0DMV8,P0DMV9 - figure legend:6-3|comment:HLA-DRB1*0401;Inhibitor HLA-DRB1*0701|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/20 2020/10/15 - rogid:YdQX0KNIxO5tYjgm6hdRRZfNlk49606 - false - biotin tag:?-? - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation) intact:EBI-11820565 uniprotkb:P01911 - intact:EBI-1033104|uniprotkb:O19717|uniprotkb:O19739|uniprotkb:P13759|uniprotkb:Q29875|uniprotkb:Q30145|uniprotkb:Q9GIX9|uniprotkb:Q9GIY4|uniprotkb:Q9MY13|uniprotkb:Q9XRY5|uniprotkb:Q0PQ39|uniprotkb:Q14280|uniprotkb:Q14QT2|uniprotkb:Q155F7|uniprotkb:Q19AF2|uniprotkb:Q19K86|uniprotkb:Q1AP33|uniprotkb:Q1G0Z9|uniprotkb:Q1JRP3|uniprotkb:Q1KLJ6|uniprotkb:Q27PR6|uniprotkb:Q27PR7|uniprotkb:Q29673|uniprotkb:Q29720|uniprotkb:Q29722|uniprotkb:Q29734|uniprotkb:Q29770|uniprotkb:Q29771|uniprotkb:A0MWF2|uniprotkb:A0N0W1|uniprotkb:A2ICT1|uniprotkb:A2TGX3|uniprotkb:A4F5N0|uniprotkb:A4ZXA5|uniprotkb:A4ZXA6|uniprotkb:A4ZY86|uniprotkb:A5H000|ensembl:ENSP00000353099|uniprotkb:A5HKN8|uniprotkb:A7DZP9|uniprotkb:A7LA26|uniprotkb:A7UHG2|uniprotkb:A7X5B1|uniprotkb:A7X5B7|uniprotkb:A7X5E0|uniprotkb:A7X5E6|uniprotkb:A7X5H8|uniprotkb:A7X5J4|uniprotkb:A7X5K7|uniprotkb:A8K098|uniprotkb:A8YQE9|uniprotkb:A9JPG0|uniprotkb:B0BK85|uniprotkb:B1GWE7|uniprotkb:B2CR03|uniprotkb:B0LUZ6|uniprotkb:B0UYW1|uniprotkb:Q768U2|uniprotkb:Q29772|uniprotkb:Q29790|uniprotkb:Q29792|uniprotkb:Q29800|uniprotkb:Q29806|uniprotkb:Q29833|uniprotkb:Q29874|uniprotkb:Q29886|uniprotkb:Q29968|uniprotkb:Q29974|uniprotkb:Q29975|uniprotkb:Q2A120|uniprotkb:Q2HZE5|uniprotkb:Q2L9H4|uniprotkb:Q2LE76|uniprotkb:Q2MF40|uniprotkb:Q2MJA6|uniprotkb:Q2MZ92|uniprotkb:Q2VQU1|uniprotkb:Q2YHQ2|uniprotkb:Q30006|uniprotkb:Q30108|uniprotkb:Q30112|uniprotkb:Q30115|uniprotkb:Q30116|uniprotkb:Q30117|uniprotkb:Q30120|uniprotkb:Q30134|uniprotkb:Q30142|uniprotkb:Q30149|uniprotkb:Q30159|uniprotkb:Q30166|uniprotkb:Q30167|uniprotkb:Q30200|uniprotkb:Q307W5|uniprotkb:Q31636|uniprotkb:Q32MY7|uniprotkb:Q3HUP9|uniprotkb:Q3KTM1|uniprotkb:Q3LA84|uniprotkb:Q3LA87|uniprotkb:Q3LA88|uniprotkb:Q3LA89|uniprotkb:Q3LA90|uniprotkb:Q3LA91|uniprotkb:Q3LA92|uniprotkb:Q3LA93|uniprotkb:Q3LA94|uniprotkb:Q3LA95|uniprotkb:Q3LA96|uniprotkb:Q3LA97|uniprotkb:Q3LA98|uniprotkb:Q3LA99|uniprotkb:Q3LAA0|uniprotkb:Q3LAA1|uniprotkb:Q3LAA2|uniprotkb:Q3MQ60|uniprotkb:Q3T919|uniprotkb:Q4PRC3|uniprotkb:Q4PRC5|uniprotkb:Q4VZY7|uniprotkb:Q53IG1|uniprotkb:Q56FN9|uniprotkb:Q56FP1|uniprotkb:Q56FP2|uniprotkb:Q56FP3|uniprotkb:Q58F52|uniprotkb:Q5BM92|uniprotkb:Q5EER6|uniprotkb:Q5K3W2|uniprotkb:Q5NDB9|uniprotkb:Q5U9W6|uniprotkb:Q5UBA2|uniprotkb:Q5UT58|uniprotkb:Q5W3L4|uniprotkb:Q5Y7A7|uniprotkb:Q5Y7B0|uniprotkb:Q5Y7B9|uniprotkb:Q5Y7E9|uniprotkb:Q5Y7G0|uniprotkb:Q683P7|uniprotkb:Q6REE2|uniprotkb:Q6T865|uniprotkb:Q6U387|uniprotkb:Q701T1|uniprotkb:Q70GL2|uniprotkb:Q70Q85|uniprotkb:Q768U4|uniprotkb:Q7M2H4|uniprotkb:Q7YNY9|uniprotkb:Q7YP03|uniprotkb:Q7YP04|uniprotkb:Q7YQ26|uniprotkb:Q7YQA3|uniprotkb:Q7YQA5|uniprotkb:Q860D8|uniprotkb:Q860D9|uniprotkb:Q860E5|uniprotkb:Q860H8|uniprotkb:Q860S0|uniprotkb:Q860Z3|uniprotkb:Q861G6|uniprotkb:Q861H0|uniprotkb:Q861H4|uniprotkb:Q861H5|uniprotkb:Q861H7|uniprotkb:Q861H8|uniprotkb:Q8HWQ6|uniprotkb:Q8MH59|uniprotkb:Q8MH60|uniprotkb:Q8WLU3|uniprotkb:Q8WMA0|uniprotkb:Q95348|uniprotkb:Q95383|uniprotkb:Q95389|uniprotkb:Q95461|uniprotkb:Q95HK1|uniprotkb:Q95HL0|uniprotkb:Q95HL1|uniprotkb:Q95IE3|uniprotkb:Q95IG2|uniprotkb:Q95IT6|uniprotkb:Q96HZ9|uniprotkb:Q9BCL7|uniprotkb:Q9BCP0|uniprotkb:Q9BCP1|uniprotkb:Q9BCP2|uniprotkb:Q9BCP5|uniprotkb:Q9BD21|uniprotkb:Q9BD33|uniprotkb:Q9BD40|uniprotkb:Q9GIK5|uniprotkb:Q9GIL5|uniprotkb:Q9GIL6|uniprotkb:Q9GIP3|uniprotkb:Q9GIX8|uniprotkb:Q9GIY0|uniprotkb:Q9GIY1|uniprotkb:Q9GIY2|uniprotkb:B2LVF9|uniprotkb:B2NJ29|uniprotkb:B2ZCY1|uniprotkb:B3VTP8|uniprotkb:B3VTQ3|uniprotkb:B5A8Y2|uniprotkb:B5A8Y3|uniprotkb:C0LAB5|uniprotkb:B5B8U0|uniprotkb:B5B9V5|uniprotkb:B5B9V6|uniprotkb:B5LZ25|uniprotkb:B5QSK8|uniprotkb:B6VCX2|uniprotkb:B6VEL9|uniprotkb:B7UDB2|uniprotkb:B9VRA4|uniprotkb:B9X248|uniprotkb:Q0PGR5|uniprotkb:O02876|uniprotkb:O02930|uniprotkb:O19585|uniprotkb:O19718|uniprotkb:O19788|uniprotkb:O46699|uniprotkb:O46793|uniprotkb:O46872|uniprotkb:O62869|uniprotkb:O62889|uniprotkb:O77969|uniprotkb:O78047|uniprotkb:O78210|uniprotkb:O98212|uniprotkb:P01912|uniprotkb:P01914|uniprotkb:P04229|uniprotkb:P13758|uniprotkb:P13760|uniprotkb:P13761|uniprotkb:P20039|uniprotkb:P79545|uniprotkb:Q06662|intact:EBI-3866098|intact:EBI-13953066|uniprotkb:Q9GIY3|uniprotkb:Q9GJ25|uniprotkb:Q9GJ56|uniprotkb:Q9GJ57|uniprotkb:Q9GJ58|uniprotkb:Q9GJ60|uniprotkb:Q9GJF8|uniprotkb:Q9GJF9|uniprotkb:Q9GJG0|uniprotkb:Q9MXZ0|uniprotkb:Q9MXZ5|uniprotkb:Q9MY45|uniprotkb:Q9MY56|uniprotkb:Q9MYF5|uniprotkb:Q9TPB6|uniprotkb:Q9TPW1|uniprotkb:Q9TPW3|uniprotkb:Q9TPW9|uniprotkb:Q9TPX4|uniprotkb:Q9TQ37|uniprotkb:Q9TQ91|uniprotkb:Q9TQE0|uniprotkb:Q9UBY1|uniprotkb:Q9UIM9|uniprotkb:Q9UIN0|uniprotkb:Q9XRX1|uniprotkb:Q9XRY4|uniprotkb:Q9Y453|uniprotkb:Q9Y4H7|intact:EBI-13953170|intact:EBI-2877159 psi-mi:hspa1a_hspa1b_human-1(display_short)|psi-mi:EBI-11820565(display_long) psi-mi:drb1_human(display_long)|uniprotkb:HLA-DRB1(gene name)|psi-mi:HLA-DRB1(display_short)|uniprotkb:Human leukocyte antigen DRB1(gene name synonym) psi-mi:"MI:0892"(solid phase assay) Haug et al. (2007) imex:IM-25683|pubmed:17357109 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13953125|imex:IM-25683-23 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0586"(inhibitor) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:1304"(molecule set) psi-mi:"MI:0326"(protein) - refseq:NP_002115.2|ensembl:ENSG00000196126(gene)|ensembl:ENST00000360004(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001772"(immunological synapse)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0002469"(myeloid dendritic cell antigen processing and presentation)|go:"GO:0002491"(antigen processing and presentation of endogenous peptide antigen via MHC class II)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0002842"(positive regulation of T cell mediated immune response to tumor cell)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005615"(extracellular space)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0008544"(epidermis development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016045"(detection of bacterium)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030247"(polysaccharide binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032395"(MHC class II receptor activity)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032653"(regulation of interleukin-10 production)|go:"GO:0032673"(regulation of interleukin-4 production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032831"(positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043382"(positive regulation of memory T cell differentiation)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045622"(regulation of T-helper cell differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046598"(positive regulation of viral entry into host cell)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2000516"(positive regulation of CD4-positive, alpha-beta T cell activation)|interpro:IPR000353(MHC class II, beta chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1A6A|rcsb pdb:1AQD|rcsb pdb:1BX2|rcsb pdb:1D5M|rcsb pdb:1D5X|rcsb pdb:1D5Z|rcsb pdb:1D6E|rcsb pdb:1DLH|rcsb pdb:1FYT|rcsb pdb:1HXY|rcsb pdb:1J8H|rcsb pdb:1JWM|rcsb pdb:1JWS|rcsb pdb:1JWU|rcsb pdb:1KG0|rcsb pdb:1KLG|rcsb pdb:1KLU|rcsb pdb:1LO5|rcsb pdb:1PYW|rcsb pdb:1R5I|rcsb pdb:1SEB|rcsb pdb:1SJE|rcsb pdb:1SJH|rcsb pdb:1T5W|rcsb pdb:1T5X|rcsb pdb:1YMM|rcsb pdb:2FSE|rcsb pdb:2G9H|rcsb pdb:2IAM|rcsb pdb:2IAN|rcsb pdb:2ICW|rcsb pdb:2IPK|rcsb pdb:2OJE|rcsb pdb:2SEB|rcsb pdb:2WBJ|rcsb pdb:2XN9|rcsb pdb:3L6F|rcsb pdb:3O6F|rcsb pdb:3PDO|rcsb pdb:3PGC|rcsb pdb:3PGD|rcsb pdb:3QXA|rcsb pdb:3QXD|rcsb pdb:3S4S|rcsb pdb:3S5L|rcsb pdb:3T0E|rcsb pdb:4AEN|rcsb pdb:4AH2|rcsb pdb:4C56|rcsb pdb:4E41|rcsb pdb:4FQX|rcsb pdb:4GBX|rcsb pdb:4I5B|rcsb pdb:4IS6|rcsb pdb:4MCY|rcsb pdb:4MCZ|rcsb pdb:4MD0|rcsb pdb:4MD4|rcsb pdb:4MD5|rcsb pdb:4MDI|rcsb pdb:4MDJ|rcsb pdb:4OV5|rcsb pdb:4X5W|rcsb pdb:4X5X|rcsb pdb:4Y19|rcsb pdb:4Y1A|rcsb pdb:5JLZ|rcsb pdb:5LAX|rcsb pdb:5NI9|rcsb pdb:5NIG|rcsb pdb:6BIJ|rcsb pdb:6BIL|rcsb pdb:6BIN|rcsb pdb:6BIR|rcsb pdb:6BIV|rcsb pdb:6BIX|rcsb pdb:6BIY|rcsb pdb:6BIZ|rcsb pdb:6CPL|rcsb pdb:6CPN|rcsb pdb:6CPO|rcsb pdb:6CQJ|rcsb pdb:6CQL|rcsb pdb:6CQN|rcsb pdb:6CQQ|rcsb pdb:6CQR|rcsb pdb:6HBY|rcsb pdb:6NIX|rcsb pdb:6QZA|rcsb pdb:6QZC|rcsb pdb:6QZD|rcsb pdb:6R0E|rcsb pdb:6V0Y|rcsb pdb:6V13|rcsb pdb:6V15|rcsb pdb:6V18|rcsb pdb:6V19|rcsb pdb:6V1A|reactome:R-HSA-202424|reactome:R-HSA-202427|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-2132295|reactome:R-HSA-389948|reactome:R-HSA-877300|refseq:XP_011546040.1|refseq:NP_001230894.1 - comment:P0DMV8,P0DMV9 - figure legend:6-4|comment:HLA-DRB1*0401;Inhibitor HLA-DRB1*0401|comment:Using recombinant HLA-DRB1*0401 lacking the transmembrane domain produced the same result.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/20 2020/10/15 - rogid:YdQX0KNIxO5tYjgm6hdRRZfNlk49606 - false - - - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation) intact:EBI-11820565 uniprotkb:P01911 - intact:EBI-1033104|uniprotkb:O19717|uniprotkb:O19739|uniprotkb:P13759|uniprotkb:Q29875|uniprotkb:Q30145|uniprotkb:Q9GIX9|uniprotkb:Q9GIY4|uniprotkb:Q9MY13|uniprotkb:Q9XRY5|uniprotkb:Q0PQ39|uniprotkb:Q14280|uniprotkb:Q14QT2|uniprotkb:Q155F7|uniprotkb:Q19AF2|uniprotkb:Q19K86|uniprotkb:Q1AP33|uniprotkb:Q1G0Z9|uniprotkb:Q1JRP3|uniprotkb:Q1KLJ6|uniprotkb:Q27PR6|uniprotkb:Q27PR7|uniprotkb:Q29673|uniprotkb:Q29720|uniprotkb:Q29722|uniprotkb:Q29734|uniprotkb:Q29770|uniprotkb:Q29771|uniprotkb:A0MWF2|uniprotkb:A0N0W1|uniprotkb:A2ICT1|uniprotkb:A2TGX3|uniprotkb:A4F5N0|uniprotkb:A4ZXA5|uniprotkb:A4ZXA6|uniprotkb:A4ZY86|uniprotkb:A5H000|ensembl:ENSP00000353099|uniprotkb:A5HKN8|uniprotkb:A7DZP9|uniprotkb:A7LA26|uniprotkb:A7UHG2|uniprotkb:A7X5B1|uniprotkb:A7X5B7|uniprotkb:A7X5E0|uniprotkb:A7X5E6|uniprotkb:A7X5H8|uniprotkb:A7X5J4|uniprotkb:A7X5K7|uniprotkb:A8K098|uniprotkb:A8YQE9|uniprotkb:A9JPG0|uniprotkb:B0BK85|uniprotkb:B1GWE7|uniprotkb:B2CR03|uniprotkb:B0LUZ6|uniprotkb:B0UYW1|uniprotkb:Q768U2|uniprotkb:Q29772|uniprotkb:Q29790|uniprotkb:Q29792|uniprotkb:Q29800|uniprotkb:Q29806|uniprotkb:Q29833|uniprotkb:Q29874|uniprotkb:Q29886|uniprotkb:Q29968|uniprotkb:Q29974|uniprotkb:Q29975|uniprotkb:Q2A120|uniprotkb:Q2HZE5|uniprotkb:Q2L9H4|uniprotkb:Q2LE76|uniprotkb:Q2MF40|uniprotkb:Q2MJA6|uniprotkb:Q2MZ92|uniprotkb:Q2VQU1|uniprotkb:Q2YHQ2|uniprotkb:Q30006|uniprotkb:Q30108|uniprotkb:Q30112|uniprotkb:Q30115|uniprotkb:Q30116|uniprotkb:Q30117|uniprotkb:Q30120|uniprotkb:Q30134|uniprotkb:Q30142|uniprotkb:Q30149|uniprotkb:Q30159|uniprotkb:Q30166|uniprotkb:Q30167|uniprotkb:Q30200|uniprotkb:Q307W5|uniprotkb:Q31636|uniprotkb:Q32MY7|uniprotkb:Q3HUP9|uniprotkb:Q3KTM1|uniprotkb:Q3LA84|uniprotkb:Q3LA87|uniprotkb:Q3LA88|uniprotkb:Q3LA89|uniprotkb:Q3LA90|uniprotkb:Q3LA91|uniprotkb:Q3LA92|uniprotkb:Q3LA93|uniprotkb:Q3LA94|uniprotkb:Q3LA95|uniprotkb:Q3LA96|uniprotkb:Q3LA97|uniprotkb:Q3LA98|uniprotkb:Q3LA99|uniprotkb:Q3LAA0|uniprotkb:Q3LAA1|uniprotkb:Q3LAA2|uniprotkb:Q3MQ60|uniprotkb:Q3T919|uniprotkb:Q4PRC3|uniprotkb:Q4PRC5|uniprotkb:Q4VZY7|uniprotkb:Q53IG1|uniprotkb:Q56FN9|uniprotkb:Q56FP1|uniprotkb:Q56FP2|uniprotkb:Q56FP3|uniprotkb:Q58F52|uniprotkb:Q5BM92|uniprotkb:Q5EER6|uniprotkb:Q5K3W2|uniprotkb:Q5NDB9|uniprotkb:Q5U9W6|uniprotkb:Q5UBA2|uniprotkb:Q5UT58|uniprotkb:Q5W3L4|uniprotkb:Q5Y7A7|uniprotkb:Q5Y7B0|uniprotkb:Q5Y7B9|uniprotkb:Q5Y7E9|uniprotkb:Q5Y7G0|uniprotkb:Q683P7|uniprotkb:Q6REE2|uniprotkb:Q6T865|uniprotkb:Q6U387|uniprotkb:Q701T1|uniprotkb:Q70GL2|uniprotkb:Q70Q85|uniprotkb:Q768U4|uniprotkb:Q7M2H4|uniprotkb:Q7YNY9|uniprotkb:Q7YP03|uniprotkb:Q7YP04|uniprotkb:Q7YQ26|uniprotkb:Q7YQA3|uniprotkb:Q7YQA5|uniprotkb:Q860D8|uniprotkb:Q860D9|uniprotkb:Q860E5|uniprotkb:Q860H8|uniprotkb:Q860S0|uniprotkb:Q860Z3|uniprotkb:Q861G6|uniprotkb:Q861H0|uniprotkb:Q861H4|uniprotkb:Q861H5|uniprotkb:Q861H7|uniprotkb:Q861H8|uniprotkb:Q8HWQ6|uniprotkb:Q8MH59|uniprotkb:Q8MH60|uniprotkb:Q8WLU3|uniprotkb:Q8WMA0|uniprotkb:Q95348|uniprotkb:Q95383|uniprotkb:Q95389|uniprotkb:Q95461|uniprotkb:Q95HK1|uniprotkb:Q95HL0|uniprotkb:Q95HL1|uniprotkb:Q95IE3|uniprotkb:Q95IG2|uniprotkb:Q95IT6|uniprotkb:Q96HZ9|uniprotkb:Q9BCL7|uniprotkb:Q9BCP0|uniprotkb:Q9BCP1|uniprotkb:Q9BCP2|uniprotkb:Q9BCP5|uniprotkb:Q9BD21|uniprotkb:Q9BD33|uniprotkb:Q9BD40|uniprotkb:Q9GIK5|uniprotkb:Q9GIL5|uniprotkb:Q9GIL6|uniprotkb:Q9GIP3|uniprotkb:Q9GIX8|uniprotkb:Q9GIY0|uniprotkb:Q9GIY1|uniprotkb:Q9GIY2|uniprotkb:B2LVF9|uniprotkb:B2NJ29|uniprotkb:B2ZCY1|uniprotkb:B3VTP8|uniprotkb:B3VTQ3|uniprotkb:B5A8Y2|uniprotkb:B5A8Y3|uniprotkb:C0LAB5|uniprotkb:B5B8U0|uniprotkb:B5B9V5|uniprotkb:B5B9V6|uniprotkb:B5LZ25|uniprotkb:B5QSK8|uniprotkb:B6VCX2|uniprotkb:B6VEL9|uniprotkb:B7UDB2|uniprotkb:B9VRA4|uniprotkb:B9X248|uniprotkb:Q0PGR5|uniprotkb:O02876|uniprotkb:O02930|uniprotkb:O19585|uniprotkb:O19718|uniprotkb:O19788|uniprotkb:O46699|uniprotkb:O46793|uniprotkb:O46872|uniprotkb:O62869|uniprotkb:O62889|uniprotkb:O77969|uniprotkb:O78047|uniprotkb:O78210|uniprotkb:O98212|uniprotkb:P01912|uniprotkb:P01914|uniprotkb:P04229|uniprotkb:P13758|uniprotkb:P13760|uniprotkb:P13761|uniprotkb:P20039|uniprotkb:P79545|uniprotkb:Q06662|intact:EBI-3866098|intact:EBI-13953066|uniprotkb:Q9GIY3|uniprotkb:Q9GJ25|uniprotkb:Q9GJ56|uniprotkb:Q9GJ57|uniprotkb:Q9GJ58|uniprotkb:Q9GJ60|uniprotkb:Q9GJF8|uniprotkb:Q9GJF9|uniprotkb:Q9GJG0|uniprotkb:Q9MXZ0|uniprotkb:Q9MXZ5|uniprotkb:Q9MY45|uniprotkb:Q9MY56|uniprotkb:Q9MYF5|uniprotkb:Q9TPB6|uniprotkb:Q9TPW1|uniprotkb:Q9TPW3|uniprotkb:Q9TPW9|uniprotkb:Q9TPX4|uniprotkb:Q9TQ37|uniprotkb:Q9TQ91|uniprotkb:Q9TQE0|uniprotkb:Q9UBY1|uniprotkb:Q9UIM9|uniprotkb:Q9UIN0|uniprotkb:Q9XRX1|uniprotkb:Q9XRY4|uniprotkb:Q9Y453|uniprotkb:Q9Y4H7|intact:EBI-13953170|intact:EBI-2877159 psi-mi:hspa1a_hspa1b_human-1(display_short)|psi-mi:EBI-11820565(display_long) psi-mi:drb1_human(display_long)|uniprotkb:HLA-DRB1(gene name)|psi-mi:HLA-DRB1(display_short)|uniprotkb:Human leukocyte antigen DRB1(gene name synonym) psi-mi:"MI:0892"(solid phase assay) Haug et al. (2007) imex:IM-25683|pubmed:17357109 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13953125|imex:IM-25683-23 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:1304"(molecule set) psi-mi:"MI:0326"(protein) - refseq:NP_002115.2|ensembl:ENSG00000196126(gene)|ensembl:ENST00000360004(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001772"(immunological synapse)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0002469"(myeloid dendritic cell antigen processing and presentation)|go:"GO:0002491"(antigen processing and presentation of endogenous peptide antigen via MHC class II)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0002842"(positive regulation of T cell mediated immune response to tumor cell)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005615"(extracellular space)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0008544"(epidermis development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016045"(detection of bacterium)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030247"(polysaccharide binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032395"(MHC class II receptor activity)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032653"(regulation of interleukin-10 production)|go:"GO:0032673"(regulation of interleukin-4 production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032831"(positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043382"(positive regulation of memory T cell differentiation)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045622"(regulation of T-helper cell differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046598"(positive regulation of viral entry into host cell)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2000516"(positive regulation of CD4-positive, alpha-beta T cell activation)|interpro:IPR000353(MHC class II, beta chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1A6A|rcsb pdb:1AQD|rcsb pdb:1BX2|rcsb pdb:1D5M|rcsb pdb:1D5X|rcsb pdb:1D5Z|rcsb pdb:1D6E|rcsb pdb:1DLH|rcsb pdb:1FYT|rcsb pdb:1HXY|rcsb pdb:1J8H|rcsb pdb:1JWM|rcsb pdb:1JWS|rcsb pdb:1JWU|rcsb pdb:1KG0|rcsb pdb:1KLG|rcsb pdb:1KLU|rcsb pdb:1LO5|rcsb pdb:1PYW|rcsb pdb:1R5I|rcsb pdb:1SEB|rcsb pdb:1SJE|rcsb pdb:1SJH|rcsb pdb:1T5W|rcsb pdb:1T5X|rcsb pdb:1YMM|rcsb pdb:2FSE|rcsb pdb:2G9H|rcsb pdb:2IAM|rcsb pdb:2IAN|rcsb pdb:2ICW|rcsb pdb:2IPK|rcsb pdb:2OJE|rcsb pdb:2SEB|rcsb pdb:2WBJ|rcsb pdb:2XN9|rcsb pdb:3L6F|rcsb pdb:3O6F|rcsb pdb:3PDO|rcsb pdb:3PGC|rcsb pdb:3PGD|rcsb pdb:3QXA|rcsb pdb:3QXD|rcsb pdb:3S4S|rcsb pdb:3S5L|rcsb pdb:3T0E|rcsb pdb:4AEN|rcsb pdb:4AH2|rcsb pdb:4C56|rcsb pdb:4E41|rcsb pdb:4FQX|rcsb pdb:4GBX|rcsb pdb:4I5B|rcsb pdb:4IS6|rcsb pdb:4MCY|rcsb pdb:4MCZ|rcsb pdb:4MD0|rcsb pdb:4MD4|rcsb pdb:4MD5|rcsb pdb:4MDI|rcsb pdb:4MDJ|rcsb pdb:4OV5|rcsb pdb:4X5W|rcsb pdb:4X5X|rcsb pdb:4Y19|rcsb pdb:4Y1A|rcsb pdb:5JLZ|rcsb pdb:5LAX|rcsb pdb:5NI9|rcsb pdb:5NIG|rcsb pdb:6BIJ|rcsb pdb:6BIL|rcsb pdb:6BIN|rcsb pdb:6BIR|rcsb pdb:6BIV|rcsb pdb:6BIX|rcsb pdb:6BIY|rcsb pdb:6BIZ|rcsb pdb:6CPL|rcsb pdb:6CPN|rcsb pdb:6CPO|rcsb pdb:6CQJ|rcsb pdb:6CQL|rcsb pdb:6CQN|rcsb pdb:6CQQ|rcsb pdb:6CQR|rcsb pdb:6HBY|rcsb pdb:6NIX|rcsb pdb:6QZA|rcsb pdb:6QZC|rcsb pdb:6QZD|rcsb pdb:6R0E|rcsb pdb:6V0Y|rcsb pdb:6V13|rcsb pdb:6V15|rcsb pdb:6V18|rcsb pdb:6V19|rcsb pdb:6V1A|reactome:R-HSA-202424|reactome:R-HSA-202427|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-2132295|reactome:R-HSA-389948|reactome:R-HSA-877300|refseq:XP_011546040.1|refseq:NP_001230894.1 - comment:P0DMV8,P0DMV9 - figure legend:6-4|comment:HLA-DRB1*0401;Inhibitor HLA-DRB1*0401|comment:Using recombinant HLA-DRB1*0401 lacking the transmembrane domain produced the same result.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/20 2020/10/15 - rogid:YdQX0KNIxO5tYjgm6hdRRZfNlk49606 - false - biotin tag:?-? - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation) intact:EBI-11820565 uniprotkb:A0A1V1IGJ9 - intact:EBI-25339774 psi-mi:hspa1a_hspa1b_human-1(display_short)|psi-mi:EBI-11820565(display_long) psi-mi:a0a1v1igj9_human(display_long)|uniprotkb:HLA-DRB1(gene name)|psi-mi:HLA-DRB1(display_short) psi-mi:"MI:0892"(solid phase assay) Haug et al. (2007) imex:IM-25683|pubmed:17357109 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13953133|imex:IM-25683-24 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0586"(inhibitor) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:1304"(molecule set) psi-mi:"MI:0326"(protein) - interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR000353(MHC class II, beta chain, N-terminal) - comment:P0DMV8,P0DMV9 no-uniprot-update: figure legend:6-5|comment:HLA-DRB1*0401;Inhibitor HLA-DRB1*0402|comment:Using recombinant HLA-DRB1*0402 lacking the transmembrane domain produced the same result.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/20 2020/10/15 - rogid:t0oiEebDmTMAhQ97YLbgIkwvFek9606 - false - mutation:99-99,100-100,115-115,96-96 - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation) intact:EBI-11820565 uniprotkb:P01911 - intact:EBI-1033104|uniprotkb:O19717|uniprotkb:O19739|uniprotkb:P13759|uniprotkb:Q29875|uniprotkb:Q30145|uniprotkb:Q9GIX9|uniprotkb:Q9GIY4|uniprotkb:Q9MY13|uniprotkb:Q9XRY5|uniprotkb:Q0PQ39|uniprotkb:Q14280|uniprotkb:Q14QT2|uniprotkb:Q155F7|uniprotkb:Q19AF2|uniprotkb:Q19K86|uniprotkb:Q1AP33|uniprotkb:Q1G0Z9|uniprotkb:Q1JRP3|uniprotkb:Q1KLJ6|uniprotkb:Q27PR6|uniprotkb:Q27PR7|uniprotkb:Q29673|uniprotkb:Q29720|uniprotkb:Q29722|uniprotkb:Q29734|uniprotkb:Q29770|uniprotkb:Q29771|uniprotkb:A0MWF2|uniprotkb:A0N0W1|uniprotkb:A2ICT1|uniprotkb:A2TGX3|uniprotkb:A4F5N0|uniprotkb:A4ZXA5|uniprotkb:A4ZXA6|uniprotkb:A4ZY86|uniprotkb:A5H000|ensembl:ENSP00000353099|uniprotkb:A5HKN8|uniprotkb:A7DZP9|uniprotkb:A7LA26|uniprotkb:A7UHG2|uniprotkb:A7X5B1|uniprotkb:A7X5B7|uniprotkb:A7X5E0|uniprotkb:A7X5E6|uniprotkb:A7X5H8|uniprotkb:A7X5J4|uniprotkb:A7X5K7|uniprotkb:A8K098|uniprotkb:A8YQE9|uniprotkb:A9JPG0|uniprotkb:B0BK85|uniprotkb:B1GWE7|uniprotkb:B2CR03|uniprotkb:B0LUZ6|uniprotkb:B0UYW1|uniprotkb:Q768U2|uniprotkb:Q29772|uniprotkb:Q29790|uniprotkb:Q29792|uniprotkb:Q29800|uniprotkb:Q29806|uniprotkb:Q29833|uniprotkb:Q29874|uniprotkb:Q29886|uniprotkb:Q29968|uniprotkb:Q29974|uniprotkb:Q29975|uniprotkb:Q2A120|uniprotkb:Q2HZE5|uniprotkb:Q2L9H4|uniprotkb:Q2LE76|uniprotkb:Q2MF40|uniprotkb:Q2MJA6|uniprotkb:Q2MZ92|uniprotkb:Q2VQU1|uniprotkb:Q2YHQ2|uniprotkb:Q30006|uniprotkb:Q30108|uniprotkb:Q30112|uniprotkb:Q30115|uniprotkb:Q30116|uniprotkb:Q30117|uniprotkb:Q30120|uniprotkb:Q30134|uniprotkb:Q30142|uniprotkb:Q30149|uniprotkb:Q30159|uniprotkb:Q30166|uniprotkb:Q30167|uniprotkb:Q30200|uniprotkb:Q307W5|uniprotkb:Q31636|uniprotkb:Q32MY7|uniprotkb:Q3HUP9|uniprotkb:Q3KTM1|uniprotkb:Q3LA84|uniprotkb:Q3LA87|uniprotkb:Q3LA88|uniprotkb:Q3LA89|uniprotkb:Q3LA90|uniprotkb:Q3LA91|uniprotkb:Q3LA92|uniprotkb:Q3LA93|uniprotkb:Q3LA94|uniprotkb:Q3LA95|uniprotkb:Q3LA96|uniprotkb:Q3LA97|uniprotkb:Q3LA98|uniprotkb:Q3LA99|uniprotkb:Q3LAA0|uniprotkb:Q3LAA1|uniprotkb:Q3LAA2|uniprotkb:Q3MQ60|uniprotkb:Q3T919|uniprotkb:Q4PRC3|uniprotkb:Q4PRC5|uniprotkb:Q4VZY7|uniprotkb:Q53IG1|uniprotkb:Q56FN9|uniprotkb:Q56FP1|uniprotkb:Q56FP2|uniprotkb:Q56FP3|uniprotkb:Q58F52|uniprotkb:Q5BM92|uniprotkb:Q5EER6|uniprotkb:Q5K3W2|uniprotkb:Q5NDB9|uniprotkb:Q5U9W6|uniprotkb:Q5UBA2|uniprotkb:Q5UT58|uniprotkb:Q5W3L4|uniprotkb:Q5Y7A7|uniprotkb:Q5Y7B0|uniprotkb:Q5Y7B9|uniprotkb:Q5Y7E9|uniprotkb:Q5Y7G0|uniprotkb:Q683P7|uniprotkb:Q6REE2|uniprotkb:Q6T865|uniprotkb:Q6U387|uniprotkb:Q701T1|uniprotkb:Q70GL2|uniprotkb:Q70Q85|uniprotkb:Q768U4|uniprotkb:Q7M2H4|uniprotkb:Q7YNY9|uniprotkb:Q7YP03|uniprotkb:Q7YP04|uniprotkb:Q7YQ26|uniprotkb:Q7YQA3|uniprotkb:Q7YQA5|uniprotkb:Q860D8|uniprotkb:Q860D9|uniprotkb:Q860E5|uniprotkb:Q860H8|uniprotkb:Q860S0|uniprotkb:Q860Z3|uniprotkb:Q861G6|uniprotkb:Q861H0|uniprotkb:Q861H4|uniprotkb:Q861H5|uniprotkb:Q861H7|uniprotkb:Q861H8|uniprotkb:Q8HWQ6|uniprotkb:Q8MH59|uniprotkb:Q8MH60|uniprotkb:Q8WLU3|uniprotkb:Q8WMA0|uniprotkb:Q95348|uniprotkb:Q95383|uniprotkb:Q95389|uniprotkb:Q95461|uniprotkb:Q95HK1|uniprotkb:Q95HL0|uniprotkb:Q95HL1|uniprotkb:Q95IE3|uniprotkb:Q95IG2|uniprotkb:Q95IT6|uniprotkb:Q96HZ9|uniprotkb:Q9BCL7|uniprotkb:Q9BCP0|uniprotkb:Q9BCP1|uniprotkb:Q9BCP2|uniprotkb:Q9BCP5|uniprotkb:Q9BD21|uniprotkb:Q9BD33|uniprotkb:Q9BD40|uniprotkb:Q9GIK5|uniprotkb:Q9GIL5|uniprotkb:Q9GIL6|uniprotkb:Q9GIP3|uniprotkb:Q9GIX8|uniprotkb:Q9GIY0|uniprotkb:Q9GIY1|uniprotkb:Q9GIY2|uniprotkb:B2LVF9|uniprotkb:B2NJ29|uniprotkb:B2ZCY1|uniprotkb:B3VTP8|uniprotkb:B3VTQ3|uniprotkb:B5A8Y2|uniprotkb:B5A8Y3|uniprotkb:C0LAB5|uniprotkb:B5B8U0|uniprotkb:B5B9V5|uniprotkb:B5B9V6|uniprotkb:B5LZ25|uniprotkb:B5QSK8|uniprotkb:B6VCX2|uniprotkb:B6VEL9|uniprotkb:B7UDB2|uniprotkb:B9VRA4|uniprotkb:B9X248|uniprotkb:Q0PGR5|uniprotkb:O02876|uniprotkb:O02930|uniprotkb:O19585|uniprotkb:O19718|uniprotkb:O19788|uniprotkb:O46699|uniprotkb:O46793|uniprotkb:O46872|uniprotkb:O62869|uniprotkb:O62889|uniprotkb:O77969|uniprotkb:O78047|uniprotkb:O78210|uniprotkb:O98212|uniprotkb:P01912|uniprotkb:P01914|uniprotkb:P04229|uniprotkb:P13758|uniprotkb:P13760|uniprotkb:P13761|uniprotkb:P20039|uniprotkb:P79545|uniprotkb:Q06662|intact:EBI-3866098|intact:EBI-13953066|uniprotkb:Q9GIY3|uniprotkb:Q9GJ25|uniprotkb:Q9GJ56|uniprotkb:Q9GJ57|uniprotkb:Q9GJ58|uniprotkb:Q9GJ60|uniprotkb:Q9GJF8|uniprotkb:Q9GJF9|uniprotkb:Q9GJG0|uniprotkb:Q9MXZ0|uniprotkb:Q9MXZ5|uniprotkb:Q9MY45|uniprotkb:Q9MY56|uniprotkb:Q9MYF5|uniprotkb:Q9TPB6|uniprotkb:Q9TPW1|uniprotkb:Q9TPW3|uniprotkb:Q9TPW9|uniprotkb:Q9TPX4|uniprotkb:Q9TQ37|uniprotkb:Q9TQ91|uniprotkb:Q9TQE0|uniprotkb:Q9UBY1|uniprotkb:Q9UIM9|uniprotkb:Q9UIN0|uniprotkb:Q9XRX1|uniprotkb:Q9XRY4|uniprotkb:Q9Y453|uniprotkb:Q9Y4H7|intact:EBI-13953170|intact:EBI-2877159 psi-mi:hspa1a_hspa1b_human-1(display_short)|psi-mi:EBI-11820565(display_long) psi-mi:drb1_human(display_long)|uniprotkb:HLA-DRB1(gene name)|psi-mi:HLA-DRB1(display_short)|uniprotkb:Human leukocyte antigen DRB1(gene name synonym) psi-mi:"MI:0892"(solid phase assay) Haug et al. (2007) imex:IM-25683|pubmed:17357109 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13953133|imex:IM-25683-24 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:1304"(molecule set) psi-mi:"MI:0326"(protein) - refseq:NP_002115.2|ensembl:ENSG00000196126(gene)|ensembl:ENST00000360004(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001772"(immunological synapse)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0002469"(myeloid dendritic cell antigen processing and presentation)|go:"GO:0002491"(antigen processing and presentation of endogenous peptide antigen via MHC class II)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0002842"(positive regulation of T cell mediated immune response to tumor cell)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005615"(extracellular space)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0008544"(epidermis development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016045"(detection of bacterium)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030247"(polysaccharide binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032395"(MHC class II receptor activity)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032653"(regulation of interleukin-10 production)|go:"GO:0032673"(regulation of interleukin-4 production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032831"(positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043382"(positive regulation of memory T cell differentiation)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045622"(regulation of T-helper cell differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046598"(positive regulation of viral entry into host cell)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2000516"(positive regulation of CD4-positive, alpha-beta T cell activation)|interpro:IPR000353(MHC class II, beta chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1A6A|rcsb pdb:1AQD|rcsb pdb:1BX2|rcsb pdb:1D5M|rcsb pdb:1D5X|rcsb pdb:1D5Z|rcsb pdb:1D6E|rcsb pdb:1DLH|rcsb pdb:1FYT|rcsb pdb:1HXY|rcsb pdb:1J8H|rcsb pdb:1JWM|rcsb pdb:1JWS|rcsb pdb:1JWU|rcsb pdb:1KG0|rcsb pdb:1KLG|rcsb pdb:1KLU|rcsb pdb:1LO5|rcsb pdb:1PYW|rcsb pdb:1R5I|rcsb pdb:1SEB|rcsb pdb:1SJE|rcsb pdb:1SJH|rcsb pdb:1T5W|rcsb pdb:1T5X|rcsb pdb:1YMM|rcsb pdb:2FSE|rcsb pdb:2G9H|rcsb pdb:2IAM|rcsb pdb:2IAN|rcsb pdb:2ICW|rcsb pdb:2IPK|rcsb pdb:2OJE|rcsb pdb:2SEB|rcsb pdb:2WBJ|rcsb pdb:2XN9|rcsb pdb:3L6F|rcsb pdb:3O6F|rcsb pdb:3PDO|rcsb pdb:3PGC|rcsb pdb:3PGD|rcsb pdb:3QXA|rcsb pdb:3QXD|rcsb pdb:3S4S|rcsb pdb:3S5L|rcsb pdb:3T0E|rcsb pdb:4AEN|rcsb pdb:4AH2|rcsb pdb:4C56|rcsb pdb:4E41|rcsb pdb:4FQX|rcsb pdb:4GBX|rcsb pdb:4I5B|rcsb pdb:4IS6|rcsb pdb:4MCY|rcsb pdb:4MCZ|rcsb pdb:4MD0|rcsb pdb:4MD4|rcsb pdb:4MD5|rcsb pdb:4MDI|rcsb pdb:4MDJ|rcsb pdb:4OV5|rcsb pdb:4X5W|rcsb pdb:4X5X|rcsb pdb:4Y19|rcsb pdb:4Y1A|rcsb pdb:5JLZ|rcsb pdb:5LAX|rcsb pdb:5NI9|rcsb pdb:5NIG|rcsb pdb:6BIJ|rcsb pdb:6BIL|rcsb pdb:6BIN|rcsb pdb:6BIR|rcsb pdb:6BIV|rcsb pdb:6BIX|rcsb pdb:6BIY|rcsb pdb:6BIZ|rcsb pdb:6CPL|rcsb pdb:6CPN|rcsb pdb:6CPO|rcsb pdb:6CQJ|rcsb pdb:6CQL|rcsb pdb:6CQN|rcsb pdb:6CQQ|rcsb pdb:6CQR|rcsb pdb:6HBY|rcsb pdb:6NIX|rcsb pdb:6QZA|rcsb pdb:6QZC|rcsb pdb:6QZD|rcsb pdb:6R0E|rcsb pdb:6V0Y|rcsb pdb:6V13|rcsb pdb:6V15|rcsb pdb:6V18|rcsb pdb:6V19|rcsb pdb:6V1A|reactome:R-HSA-202424|reactome:R-HSA-202427|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-2132295|reactome:R-HSA-389948|reactome:R-HSA-877300|refseq:XP_011546040.1|refseq:NP_001230894.1 - comment:P0DMV8,P0DMV9 - figure legend:6-5|comment:HLA-DRB1*0401;Inhibitor HLA-DRB1*0402|comment:Using recombinant HLA-DRB1*0402 lacking the transmembrane domain produced the same result.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/20 2020/10/15 - rogid:YdQX0KNIxO5tYjgm6hdRRZfNlk49606 - false - biotin tag:?-? - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation) intact:EBI-11820565 uniprotkb:P01911 - intact:EBI-1033104|uniprotkb:O19717|uniprotkb:O19739|uniprotkb:P13759|uniprotkb:Q29875|uniprotkb:Q30145|uniprotkb:Q9GIX9|uniprotkb:Q9GIY4|uniprotkb:Q9MY13|uniprotkb:Q9XRY5|uniprotkb:Q0PQ39|uniprotkb:Q14280|uniprotkb:Q14QT2|uniprotkb:Q155F7|uniprotkb:Q19AF2|uniprotkb:Q19K86|uniprotkb:Q1AP33|uniprotkb:Q1G0Z9|uniprotkb:Q1JRP3|uniprotkb:Q1KLJ6|uniprotkb:Q27PR6|uniprotkb:Q27PR7|uniprotkb:Q29673|uniprotkb:Q29720|uniprotkb:Q29722|uniprotkb:Q29734|uniprotkb:Q29770|uniprotkb:Q29771|uniprotkb:A0MWF2|uniprotkb:A0N0W1|uniprotkb:A2ICT1|uniprotkb:A2TGX3|uniprotkb:A4F5N0|uniprotkb:A4ZXA5|uniprotkb:A4ZXA6|uniprotkb:A4ZY86|uniprotkb:A5H000|ensembl:ENSP00000353099|uniprotkb:A5HKN8|uniprotkb:A7DZP9|uniprotkb:A7LA26|uniprotkb:A7UHG2|uniprotkb:A7X5B1|uniprotkb:A7X5B7|uniprotkb:A7X5E0|uniprotkb:A7X5E6|uniprotkb:A7X5H8|uniprotkb:A7X5J4|uniprotkb:A7X5K7|uniprotkb:A8K098|uniprotkb:A8YQE9|uniprotkb:A9JPG0|uniprotkb:B0BK85|uniprotkb:B1GWE7|uniprotkb:B2CR03|uniprotkb:B0LUZ6|uniprotkb:B0UYW1|uniprotkb:Q768U2|uniprotkb:Q29772|uniprotkb:Q29790|uniprotkb:Q29792|uniprotkb:Q29800|uniprotkb:Q29806|uniprotkb:Q29833|uniprotkb:Q29874|uniprotkb:Q29886|uniprotkb:Q29968|uniprotkb:Q29974|uniprotkb:Q29975|uniprotkb:Q2A120|uniprotkb:Q2HZE5|uniprotkb:Q2L9H4|uniprotkb:Q2LE76|uniprotkb:Q2MF40|uniprotkb:Q2MJA6|uniprotkb:Q2MZ92|uniprotkb:Q2VQU1|uniprotkb:Q2YHQ2|uniprotkb:Q30006|uniprotkb:Q30108|uniprotkb:Q30112|uniprotkb:Q30115|uniprotkb:Q30116|uniprotkb:Q30117|uniprotkb:Q30120|uniprotkb:Q30134|uniprotkb:Q30142|uniprotkb:Q30149|uniprotkb:Q30159|uniprotkb:Q30166|uniprotkb:Q30167|uniprotkb:Q30200|uniprotkb:Q307W5|uniprotkb:Q31636|uniprotkb:Q32MY7|uniprotkb:Q3HUP9|uniprotkb:Q3KTM1|uniprotkb:Q3LA84|uniprotkb:Q3LA87|uniprotkb:Q3LA88|uniprotkb:Q3LA89|uniprotkb:Q3LA90|uniprotkb:Q3LA91|uniprotkb:Q3LA92|uniprotkb:Q3LA93|uniprotkb:Q3LA94|uniprotkb:Q3LA95|uniprotkb:Q3LA96|uniprotkb:Q3LA97|uniprotkb:Q3LA98|uniprotkb:Q3LA99|uniprotkb:Q3LAA0|uniprotkb:Q3LAA1|uniprotkb:Q3LAA2|uniprotkb:Q3MQ60|uniprotkb:Q3T919|uniprotkb:Q4PRC3|uniprotkb:Q4PRC5|uniprotkb:Q4VZY7|uniprotkb:Q53IG1|uniprotkb:Q56FN9|uniprotkb:Q56FP1|uniprotkb:Q56FP2|uniprotkb:Q56FP3|uniprotkb:Q58F52|uniprotkb:Q5BM92|uniprotkb:Q5EER6|uniprotkb:Q5K3W2|uniprotkb:Q5NDB9|uniprotkb:Q5U9W6|uniprotkb:Q5UBA2|uniprotkb:Q5UT58|uniprotkb:Q5W3L4|uniprotkb:Q5Y7A7|uniprotkb:Q5Y7B0|uniprotkb:Q5Y7B9|uniprotkb:Q5Y7E9|uniprotkb:Q5Y7G0|uniprotkb:Q683P7|uniprotkb:Q6REE2|uniprotkb:Q6T865|uniprotkb:Q6U387|uniprotkb:Q701T1|uniprotkb:Q70GL2|uniprotkb:Q70Q85|uniprotkb:Q768U4|uniprotkb:Q7M2H4|uniprotkb:Q7YNY9|uniprotkb:Q7YP03|uniprotkb:Q7YP04|uniprotkb:Q7YQ26|uniprotkb:Q7YQA3|uniprotkb:Q7YQA5|uniprotkb:Q860D8|uniprotkb:Q860D9|uniprotkb:Q860E5|uniprotkb:Q860H8|uniprotkb:Q860S0|uniprotkb:Q860Z3|uniprotkb:Q861G6|uniprotkb:Q861H0|uniprotkb:Q861H4|uniprotkb:Q861H5|uniprotkb:Q861H7|uniprotkb:Q861H8|uniprotkb:Q8HWQ6|uniprotkb:Q8MH59|uniprotkb:Q8MH60|uniprotkb:Q8WLU3|uniprotkb:Q8WMA0|uniprotkb:Q95348|uniprotkb:Q95383|uniprotkb:Q95389|uniprotkb:Q95461|uniprotkb:Q95HK1|uniprotkb:Q95HL0|uniprotkb:Q95HL1|uniprotkb:Q95IE3|uniprotkb:Q95IG2|uniprotkb:Q95IT6|uniprotkb:Q96HZ9|uniprotkb:Q9BCL7|uniprotkb:Q9BCP0|uniprotkb:Q9BCP1|uniprotkb:Q9BCP2|uniprotkb:Q9BCP5|uniprotkb:Q9BD21|uniprotkb:Q9BD33|uniprotkb:Q9BD40|uniprotkb:Q9GIK5|uniprotkb:Q9GIL5|uniprotkb:Q9GIL6|uniprotkb:Q9GIP3|uniprotkb:Q9GIX8|uniprotkb:Q9GIY0|uniprotkb:Q9GIY1|uniprotkb:Q9GIY2|uniprotkb:B2LVF9|uniprotkb:B2NJ29|uniprotkb:B2ZCY1|uniprotkb:B3VTP8|uniprotkb:B3VTQ3|uniprotkb:B5A8Y2|uniprotkb:B5A8Y3|uniprotkb:C0LAB5|uniprotkb:B5B8U0|uniprotkb:B5B9V5|uniprotkb:B5B9V6|uniprotkb:B5LZ25|uniprotkb:B5QSK8|uniprotkb:B6VCX2|uniprotkb:B6VEL9|uniprotkb:B7UDB2|uniprotkb:B9VRA4|uniprotkb:B9X248|uniprotkb:Q0PGR5|uniprotkb:O02876|uniprotkb:O02930|uniprotkb:O19585|uniprotkb:O19718|uniprotkb:O19788|uniprotkb:O46699|uniprotkb:O46793|uniprotkb:O46872|uniprotkb:O62869|uniprotkb:O62889|uniprotkb:O77969|uniprotkb:O78047|uniprotkb:O78210|uniprotkb:O98212|uniprotkb:P01912|uniprotkb:P01914|uniprotkb:P04229|uniprotkb:P13758|uniprotkb:P13760|uniprotkb:P13761|uniprotkb:P20039|uniprotkb:P79545|uniprotkb:Q06662|intact:EBI-3866098|intact:EBI-13953066|uniprotkb:Q9GIY3|uniprotkb:Q9GJ25|uniprotkb:Q9GJ56|uniprotkb:Q9GJ57|uniprotkb:Q9GJ58|uniprotkb:Q9GJ60|uniprotkb:Q9GJF8|uniprotkb:Q9GJF9|uniprotkb:Q9GJG0|uniprotkb:Q9MXZ0|uniprotkb:Q9MXZ5|uniprotkb:Q9MY45|uniprotkb:Q9MY56|uniprotkb:Q9MYF5|uniprotkb:Q9TPB6|uniprotkb:Q9TPW1|uniprotkb:Q9TPW3|uniprotkb:Q9TPW9|uniprotkb:Q9TPX4|uniprotkb:Q9TQ37|uniprotkb:Q9TQ91|uniprotkb:Q9TQE0|uniprotkb:Q9UBY1|uniprotkb:Q9UIM9|uniprotkb:Q9UIN0|uniprotkb:Q9XRX1|uniprotkb:Q9XRY4|uniprotkb:Q9Y453|uniprotkb:Q9Y4H7|intact:EBI-13953170|intact:EBI-2877159 psi-mi:hspa1a_hspa1b_human-1(display_short)|psi-mi:EBI-11820565(display_long) psi-mi:drb1_human(display_long)|uniprotkb:HLA-DRB1(gene name)|psi-mi:HLA-DRB1(display_short)|uniprotkb:Human leukocyte antigen DRB1(gene name synonym) psi-mi:"MI:0892"(solid phase assay) Haug et al. (2007) imex:IM-25683|pubmed:17357109 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13953146|imex:IM-25683-25 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0586"(inhibitor) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:1304"(molecule set) psi-mi:"MI:0326"(protein) - refseq:NP_002115.2|ensembl:ENSG00000196126(gene)|ensembl:ENST00000360004(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001772"(immunological synapse)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0002469"(myeloid dendritic cell antigen processing and presentation)|go:"GO:0002491"(antigen processing and presentation of endogenous peptide antigen via MHC class II)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0002842"(positive regulation of T cell mediated immune response to tumor cell)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005615"(extracellular space)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0008544"(epidermis development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016045"(detection of bacterium)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030247"(polysaccharide binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032395"(MHC class II receptor activity)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032653"(regulation of interleukin-10 production)|go:"GO:0032673"(regulation of interleukin-4 production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032831"(positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043382"(positive regulation of memory T cell differentiation)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045622"(regulation of T-helper cell differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046598"(positive regulation of viral entry into host cell)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2000516"(positive regulation of CD4-positive, alpha-beta T cell activation)|interpro:IPR000353(MHC class II, beta chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1A6A|rcsb pdb:1AQD|rcsb pdb:1BX2|rcsb pdb:1D5M|rcsb pdb:1D5X|rcsb pdb:1D5Z|rcsb pdb:1D6E|rcsb pdb:1DLH|rcsb pdb:1FYT|rcsb pdb:1HXY|rcsb pdb:1J8H|rcsb pdb:1JWM|rcsb pdb:1JWS|rcsb pdb:1JWU|rcsb pdb:1KG0|rcsb pdb:1KLG|rcsb pdb:1KLU|rcsb pdb:1LO5|rcsb pdb:1PYW|rcsb pdb:1R5I|rcsb pdb:1SEB|rcsb pdb:1SJE|rcsb pdb:1SJH|rcsb pdb:1T5W|rcsb pdb:1T5X|rcsb pdb:1YMM|rcsb pdb:2FSE|rcsb pdb:2G9H|rcsb pdb:2IAM|rcsb pdb:2IAN|rcsb pdb:2ICW|rcsb pdb:2IPK|rcsb pdb:2OJE|rcsb pdb:2SEB|rcsb pdb:2WBJ|rcsb pdb:2XN9|rcsb pdb:3L6F|rcsb pdb:3O6F|rcsb pdb:3PDO|rcsb pdb:3PGC|rcsb pdb:3PGD|rcsb pdb:3QXA|rcsb pdb:3QXD|rcsb pdb:3S4S|rcsb pdb:3S5L|rcsb pdb:3T0E|rcsb pdb:4AEN|rcsb pdb:4AH2|rcsb pdb:4C56|rcsb pdb:4E41|rcsb pdb:4FQX|rcsb pdb:4GBX|rcsb pdb:4I5B|rcsb pdb:4IS6|rcsb pdb:4MCY|rcsb pdb:4MCZ|rcsb pdb:4MD0|rcsb pdb:4MD4|rcsb pdb:4MD5|rcsb pdb:4MDI|rcsb pdb:4MDJ|rcsb pdb:4OV5|rcsb pdb:4X5W|rcsb pdb:4X5X|rcsb pdb:4Y19|rcsb pdb:4Y1A|rcsb pdb:5JLZ|rcsb pdb:5LAX|rcsb pdb:5NI9|rcsb pdb:5NIG|rcsb pdb:6BIJ|rcsb pdb:6BIL|rcsb pdb:6BIN|rcsb pdb:6BIR|rcsb pdb:6BIV|rcsb pdb:6BIX|rcsb pdb:6BIY|rcsb pdb:6BIZ|rcsb pdb:6CPL|rcsb pdb:6CPN|rcsb pdb:6CPO|rcsb pdb:6CQJ|rcsb pdb:6CQL|rcsb pdb:6CQN|rcsb pdb:6CQQ|rcsb pdb:6CQR|rcsb pdb:6HBY|rcsb pdb:6NIX|rcsb pdb:6QZA|rcsb pdb:6QZC|rcsb pdb:6QZD|rcsb pdb:6R0E|rcsb pdb:6V0Y|rcsb pdb:6V13|rcsb pdb:6V15|rcsb pdb:6V18|rcsb pdb:6V19|rcsb pdb:6V1A|reactome:R-HSA-202424|reactome:R-HSA-202427|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-2132295|reactome:R-HSA-389948|reactome:R-HSA-877300|refseq:XP_011546040.1|refseq:NP_001230894.1 - comment:P0DMV8,P0DMV9 - figure legend:6-6|comment:HLA-DRB1*0401;Inhibitor HLA-DRB1*1302|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/20 2020/10/15 - rogid:YdQX0KNIxO5tYjgm6hdRRZfNlk49606 - false - mutation:115-115 - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation) intact:EBI-11820565 uniprotkb:P01911 - intact:EBI-1033104|uniprotkb:O19717|uniprotkb:O19739|uniprotkb:P13759|uniprotkb:Q29875|uniprotkb:Q30145|uniprotkb:Q9GIX9|uniprotkb:Q9GIY4|uniprotkb:Q9MY13|uniprotkb:Q9XRY5|uniprotkb:Q0PQ39|uniprotkb:Q14280|uniprotkb:Q14QT2|uniprotkb:Q155F7|uniprotkb:Q19AF2|uniprotkb:Q19K86|uniprotkb:Q1AP33|uniprotkb:Q1G0Z9|uniprotkb:Q1JRP3|uniprotkb:Q1KLJ6|uniprotkb:Q27PR6|uniprotkb:Q27PR7|uniprotkb:Q29673|uniprotkb:Q29720|uniprotkb:Q29722|uniprotkb:Q29734|uniprotkb:Q29770|uniprotkb:Q29771|uniprotkb:A0MWF2|uniprotkb:A0N0W1|uniprotkb:A2ICT1|uniprotkb:A2TGX3|uniprotkb:A4F5N0|uniprotkb:A4ZXA5|uniprotkb:A4ZXA6|uniprotkb:A4ZY86|uniprotkb:A5H000|ensembl:ENSP00000353099|uniprotkb:A5HKN8|uniprotkb:A7DZP9|uniprotkb:A7LA26|uniprotkb:A7UHG2|uniprotkb:A7X5B1|uniprotkb:A7X5B7|uniprotkb:A7X5E0|uniprotkb:A7X5E6|uniprotkb:A7X5H8|uniprotkb:A7X5J4|uniprotkb:A7X5K7|uniprotkb:A8K098|uniprotkb:A8YQE9|uniprotkb:A9JPG0|uniprotkb:B0BK85|uniprotkb:B1GWE7|uniprotkb:B2CR03|uniprotkb:B0LUZ6|uniprotkb:B0UYW1|uniprotkb:Q768U2|uniprotkb:Q29772|uniprotkb:Q29790|uniprotkb:Q29792|uniprotkb:Q29800|uniprotkb:Q29806|uniprotkb:Q29833|uniprotkb:Q29874|uniprotkb:Q29886|uniprotkb:Q29968|uniprotkb:Q29974|uniprotkb:Q29975|uniprotkb:Q2A120|uniprotkb:Q2HZE5|uniprotkb:Q2L9H4|uniprotkb:Q2LE76|uniprotkb:Q2MF40|uniprotkb:Q2MJA6|uniprotkb:Q2MZ92|uniprotkb:Q2VQU1|uniprotkb:Q2YHQ2|uniprotkb:Q30006|uniprotkb:Q30108|uniprotkb:Q30112|uniprotkb:Q30115|uniprotkb:Q30116|uniprotkb:Q30117|uniprotkb:Q30120|uniprotkb:Q30134|uniprotkb:Q30142|uniprotkb:Q30149|uniprotkb:Q30159|uniprotkb:Q30166|uniprotkb:Q30167|uniprotkb:Q30200|uniprotkb:Q307W5|uniprotkb:Q31636|uniprotkb:Q32MY7|uniprotkb:Q3HUP9|uniprotkb:Q3KTM1|uniprotkb:Q3LA84|uniprotkb:Q3LA87|uniprotkb:Q3LA88|uniprotkb:Q3LA89|uniprotkb:Q3LA90|uniprotkb:Q3LA91|uniprotkb:Q3LA92|uniprotkb:Q3LA93|uniprotkb:Q3LA94|uniprotkb:Q3LA95|uniprotkb:Q3LA96|uniprotkb:Q3LA97|uniprotkb:Q3LA98|uniprotkb:Q3LA99|uniprotkb:Q3LAA0|uniprotkb:Q3LAA1|uniprotkb:Q3LAA2|uniprotkb:Q3MQ60|uniprotkb:Q3T919|uniprotkb:Q4PRC3|uniprotkb:Q4PRC5|uniprotkb:Q4VZY7|uniprotkb:Q53IG1|uniprotkb:Q56FN9|uniprotkb:Q56FP1|uniprotkb:Q56FP2|uniprotkb:Q56FP3|uniprotkb:Q58F52|uniprotkb:Q5BM92|uniprotkb:Q5EER6|uniprotkb:Q5K3W2|uniprotkb:Q5NDB9|uniprotkb:Q5U9W6|uniprotkb:Q5UBA2|uniprotkb:Q5UT58|uniprotkb:Q5W3L4|uniprotkb:Q5Y7A7|uniprotkb:Q5Y7B0|uniprotkb:Q5Y7B9|uniprotkb:Q5Y7E9|uniprotkb:Q5Y7G0|uniprotkb:Q683P7|uniprotkb:Q6REE2|uniprotkb:Q6T865|uniprotkb:Q6U387|uniprotkb:Q701T1|uniprotkb:Q70GL2|uniprotkb:Q70Q85|uniprotkb:Q768U4|uniprotkb:Q7M2H4|uniprotkb:Q7YNY9|uniprotkb:Q7YP03|uniprotkb:Q7YP04|uniprotkb:Q7YQ26|uniprotkb:Q7YQA3|uniprotkb:Q7YQA5|uniprotkb:Q860D8|uniprotkb:Q860D9|uniprotkb:Q860E5|uniprotkb:Q860H8|uniprotkb:Q860S0|uniprotkb:Q860Z3|uniprotkb:Q861G6|uniprotkb:Q861H0|uniprotkb:Q861H4|uniprotkb:Q861H5|uniprotkb:Q861H7|uniprotkb:Q861H8|uniprotkb:Q8HWQ6|uniprotkb:Q8MH59|uniprotkb:Q8MH60|uniprotkb:Q8WLU3|uniprotkb:Q8WMA0|uniprotkb:Q95348|uniprotkb:Q95383|uniprotkb:Q95389|uniprotkb:Q95461|uniprotkb:Q95HK1|uniprotkb:Q95HL0|uniprotkb:Q95HL1|uniprotkb:Q95IE3|uniprotkb:Q95IG2|uniprotkb:Q95IT6|uniprotkb:Q96HZ9|uniprotkb:Q9BCL7|uniprotkb:Q9BCP0|uniprotkb:Q9BCP1|uniprotkb:Q9BCP2|uniprotkb:Q9BCP5|uniprotkb:Q9BD21|uniprotkb:Q9BD33|uniprotkb:Q9BD40|uniprotkb:Q9GIK5|uniprotkb:Q9GIL5|uniprotkb:Q9GIL6|uniprotkb:Q9GIP3|uniprotkb:Q9GIX8|uniprotkb:Q9GIY0|uniprotkb:Q9GIY1|uniprotkb:Q9GIY2|uniprotkb:B2LVF9|uniprotkb:B2NJ29|uniprotkb:B2ZCY1|uniprotkb:B3VTP8|uniprotkb:B3VTQ3|uniprotkb:B5A8Y2|uniprotkb:B5A8Y3|uniprotkb:C0LAB5|uniprotkb:B5B8U0|uniprotkb:B5B9V5|uniprotkb:B5B9V6|uniprotkb:B5LZ25|uniprotkb:B5QSK8|uniprotkb:B6VCX2|uniprotkb:B6VEL9|uniprotkb:B7UDB2|uniprotkb:B9VRA4|uniprotkb:B9X248|uniprotkb:Q0PGR5|uniprotkb:O02876|uniprotkb:O02930|uniprotkb:O19585|uniprotkb:O19718|uniprotkb:O19788|uniprotkb:O46699|uniprotkb:O46793|uniprotkb:O46872|uniprotkb:O62869|uniprotkb:O62889|uniprotkb:O77969|uniprotkb:O78047|uniprotkb:O78210|uniprotkb:O98212|uniprotkb:P01912|uniprotkb:P01914|uniprotkb:P04229|uniprotkb:P13758|uniprotkb:P13760|uniprotkb:P13761|uniprotkb:P20039|uniprotkb:P79545|uniprotkb:Q06662|intact:EBI-3866098|intact:EBI-13953066|uniprotkb:Q9GIY3|uniprotkb:Q9GJ25|uniprotkb:Q9GJ56|uniprotkb:Q9GJ57|uniprotkb:Q9GJ58|uniprotkb:Q9GJ60|uniprotkb:Q9GJF8|uniprotkb:Q9GJF9|uniprotkb:Q9GJG0|uniprotkb:Q9MXZ0|uniprotkb:Q9MXZ5|uniprotkb:Q9MY45|uniprotkb:Q9MY56|uniprotkb:Q9MYF5|uniprotkb:Q9TPB6|uniprotkb:Q9TPW1|uniprotkb:Q9TPW3|uniprotkb:Q9TPW9|uniprotkb:Q9TPX4|uniprotkb:Q9TQ37|uniprotkb:Q9TQ91|uniprotkb:Q9TQE0|uniprotkb:Q9UBY1|uniprotkb:Q9UIM9|uniprotkb:Q9UIN0|uniprotkb:Q9XRX1|uniprotkb:Q9XRY4|uniprotkb:Q9Y453|uniprotkb:Q9Y4H7|intact:EBI-13953170|intact:EBI-2877159 psi-mi:hspa1a_hspa1b_human-1(display_short)|psi-mi:EBI-11820565(display_long) psi-mi:drb1_human(display_long)|uniprotkb:HLA-DRB1(gene name)|psi-mi:HLA-DRB1(display_short)|uniprotkb:Human leukocyte antigen DRB1(gene name synonym) psi-mi:"MI:0892"(solid phase assay) Haug et al. (2007) imex:IM-25683|pubmed:17357109 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13953146|imex:IM-25683-25 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:1304"(molecule set) psi-mi:"MI:0326"(protein) - refseq:NP_002115.2|ensembl:ENSG00000196126(gene)|ensembl:ENST00000360004(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001772"(immunological synapse)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0002469"(myeloid dendritic cell antigen processing and presentation)|go:"GO:0002491"(antigen processing and presentation of endogenous peptide antigen via MHC class II)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0002842"(positive regulation of T cell mediated immune response to tumor cell)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005615"(extracellular space)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0008544"(epidermis development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016045"(detection of bacterium)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030247"(polysaccharide binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032395"(MHC class II receptor activity)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032653"(regulation of interleukin-10 production)|go:"GO:0032673"(regulation of interleukin-4 production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032831"(positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043382"(positive regulation of memory T cell differentiation)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045622"(regulation of T-helper cell differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046598"(positive regulation of viral entry into host cell)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2000516"(positive regulation of CD4-positive, alpha-beta T cell activation)|interpro:IPR000353(MHC class II, beta chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1A6A|rcsb pdb:1AQD|rcsb pdb:1BX2|rcsb pdb:1D5M|rcsb pdb:1D5X|rcsb pdb:1D5Z|rcsb pdb:1D6E|rcsb pdb:1DLH|rcsb pdb:1FYT|rcsb pdb:1HXY|rcsb pdb:1J8H|rcsb pdb:1JWM|rcsb pdb:1JWS|rcsb pdb:1JWU|rcsb pdb:1KG0|rcsb pdb:1KLG|rcsb pdb:1KLU|rcsb pdb:1LO5|rcsb pdb:1PYW|rcsb pdb:1R5I|rcsb pdb:1SEB|rcsb pdb:1SJE|rcsb pdb:1SJH|rcsb pdb:1T5W|rcsb pdb:1T5X|rcsb pdb:1YMM|rcsb pdb:2FSE|rcsb pdb:2G9H|rcsb pdb:2IAM|rcsb pdb:2IAN|rcsb pdb:2ICW|rcsb pdb:2IPK|rcsb pdb:2OJE|rcsb pdb:2SEB|rcsb pdb:2WBJ|rcsb pdb:2XN9|rcsb pdb:3L6F|rcsb pdb:3O6F|rcsb pdb:3PDO|rcsb pdb:3PGC|rcsb pdb:3PGD|rcsb pdb:3QXA|rcsb pdb:3QXD|rcsb pdb:3S4S|rcsb pdb:3S5L|rcsb pdb:3T0E|rcsb pdb:4AEN|rcsb pdb:4AH2|rcsb pdb:4C56|rcsb pdb:4E41|rcsb pdb:4FQX|rcsb pdb:4GBX|rcsb pdb:4I5B|rcsb pdb:4IS6|rcsb pdb:4MCY|rcsb pdb:4MCZ|rcsb pdb:4MD0|rcsb pdb:4MD4|rcsb pdb:4MD5|rcsb pdb:4MDI|rcsb pdb:4MDJ|rcsb pdb:4OV5|rcsb pdb:4X5W|rcsb pdb:4X5X|rcsb pdb:4Y19|rcsb pdb:4Y1A|rcsb pdb:5JLZ|rcsb pdb:5LAX|rcsb pdb:5NI9|rcsb pdb:5NIG|rcsb pdb:6BIJ|rcsb pdb:6BIL|rcsb pdb:6BIN|rcsb pdb:6BIR|rcsb pdb:6BIV|rcsb pdb:6BIX|rcsb pdb:6BIY|rcsb pdb:6BIZ|rcsb pdb:6CPL|rcsb pdb:6CPN|rcsb pdb:6CPO|rcsb pdb:6CQJ|rcsb pdb:6CQL|rcsb pdb:6CQN|rcsb pdb:6CQQ|rcsb pdb:6CQR|rcsb pdb:6HBY|rcsb pdb:6NIX|rcsb pdb:6QZA|rcsb pdb:6QZC|rcsb pdb:6QZD|rcsb pdb:6R0E|rcsb pdb:6V0Y|rcsb pdb:6V13|rcsb pdb:6V15|rcsb pdb:6V18|rcsb pdb:6V19|rcsb pdb:6V1A|reactome:R-HSA-202424|reactome:R-HSA-202427|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-2132295|reactome:R-HSA-389948|reactome:R-HSA-877300|refseq:XP_011546040.1|refseq:NP_001230894.1 - comment:P0DMV8,P0DMV9 - figure legend:6-6|comment:HLA-DRB1*0401;Inhibitor HLA-DRB1*1302|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/20 2020/10/15 - rogid:YdQX0KNIxO5tYjgm6hdRRZfNlk49606 - false - biotin tag:?-? - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation) intact:EBI-11820565 uniprotkb:A0A1V1IGJ9 - intact:EBI-25339774 psi-mi:hspa1a_hspa1b_human-1(display_short)|psi-mi:EBI-11820565(display_long) psi-mi:a0a1v1igj9_human(display_long)|uniprotkb:HLA-DRB1(gene name)|psi-mi:HLA-DRB1(display_short) psi-mi:"MI:0892"(solid phase assay) Haug et al. (2007) imex:IM-25683|pubmed:17357109 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13953401|imex:IM-25683-26 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0586"(inhibitor) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:1304"(molecule set) psi-mi:"MI:0326"(protein) - interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR000353(MHC class II, beta chain, N-terminal) - comment:P0DMV8,P0DMV9 no-uniprot-update: figure legend:7C|comment:HLA-DRB1*0401;Inhibitor HLA-DRB1*0401|comment:The interaction of Hsp70 with complete HLA-DR molecules cannot be significantly inhibited by HV3-region peptide fragments.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/20 2020/10/15 - rogid:t0oiEebDmTMAhQ97YLbgIkwvFek9606 - false - sufficient binding region:94-106 - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation) intact:EBI-11820565 uniprotkb:P01911 - intact:EBI-1033104|uniprotkb:O19717|uniprotkb:O19739|uniprotkb:P13759|uniprotkb:Q29875|uniprotkb:Q30145|uniprotkb:Q9GIX9|uniprotkb:Q9GIY4|uniprotkb:Q9MY13|uniprotkb:Q9XRY5|uniprotkb:Q0PQ39|uniprotkb:Q14280|uniprotkb:Q14QT2|uniprotkb:Q155F7|uniprotkb:Q19AF2|uniprotkb:Q19K86|uniprotkb:Q1AP33|uniprotkb:Q1G0Z9|uniprotkb:Q1JRP3|uniprotkb:Q1KLJ6|uniprotkb:Q27PR6|uniprotkb:Q27PR7|uniprotkb:Q29673|uniprotkb:Q29720|uniprotkb:Q29722|uniprotkb:Q29734|uniprotkb:Q29770|uniprotkb:Q29771|uniprotkb:A0MWF2|uniprotkb:A0N0W1|uniprotkb:A2ICT1|uniprotkb:A2TGX3|uniprotkb:A4F5N0|uniprotkb:A4ZXA5|uniprotkb:A4ZXA6|uniprotkb:A4ZY86|uniprotkb:A5H000|ensembl:ENSP00000353099|uniprotkb:A5HKN8|uniprotkb:A7DZP9|uniprotkb:A7LA26|uniprotkb:A7UHG2|uniprotkb:A7X5B1|uniprotkb:A7X5B7|uniprotkb:A7X5E0|uniprotkb:A7X5E6|uniprotkb:A7X5H8|uniprotkb:A7X5J4|uniprotkb:A7X5K7|uniprotkb:A8K098|uniprotkb:A8YQE9|uniprotkb:A9JPG0|uniprotkb:B0BK85|uniprotkb:B1GWE7|uniprotkb:B2CR03|uniprotkb:B0LUZ6|uniprotkb:B0UYW1|uniprotkb:Q768U2|uniprotkb:Q29772|uniprotkb:Q29790|uniprotkb:Q29792|uniprotkb:Q29800|uniprotkb:Q29806|uniprotkb:Q29833|uniprotkb:Q29874|uniprotkb:Q29886|uniprotkb:Q29968|uniprotkb:Q29974|uniprotkb:Q29975|uniprotkb:Q2A120|uniprotkb:Q2HZE5|uniprotkb:Q2L9H4|uniprotkb:Q2LE76|uniprotkb:Q2MF40|uniprotkb:Q2MJA6|uniprotkb:Q2MZ92|uniprotkb:Q2VQU1|uniprotkb:Q2YHQ2|uniprotkb:Q30006|uniprotkb:Q30108|uniprotkb:Q30112|uniprotkb:Q30115|uniprotkb:Q30116|uniprotkb:Q30117|uniprotkb:Q30120|uniprotkb:Q30134|uniprotkb:Q30142|uniprotkb:Q30149|uniprotkb:Q30159|uniprotkb:Q30166|uniprotkb:Q30167|uniprotkb:Q30200|uniprotkb:Q307W5|uniprotkb:Q31636|uniprotkb:Q32MY7|uniprotkb:Q3HUP9|uniprotkb:Q3KTM1|uniprotkb:Q3LA84|uniprotkb:Q3LA87|uniprotkb:Q3LA88|uniprotkb:Q3LA89|uniprotkb:Q3LA90|uniprotkb:Q3LA91|uniprotkb:Q3LA92|uniprotkb:Q3LA93|uniprotkb:Q3LA94|uniprotkb:Q3LA95|uniprotkb:Q3LA96|uniprotkb:Q3LA97|uniprotkb:Q3LA98|uniprotkb:Q3LA99|uniprotkb:Q3LAA0|uniprotkb:Q3LAA1|uniprotkb:Q3LAA2|uniprotkb:Q3MQ60|uniprotkb:Q3T919|uniprotkb:Q4PRC3|uniprotkb:Q4PRC5|uniprotkb:Q4VZY7|uniprotkb:Q53IG1|uniprotkb:Q56FN9|uniprotkb:Q56FP1|uniprotkb:Q56FP2|uniprotkb:Q56FP3|uniprotkb:Q58F52|uniprotkb:Q5BM92|uniprotkb:Q5EER6|uniprotkb:Q5K3W2|uniprotkb:Q5NDB9|uniprotkb:Q5U9W6|uniprotkb:Q5UBA2|uniprotkb:Q5UT58|uniprotkb:Q5W3L4|uniprotkb:Q5Y7A7|uniprotkb:Q5Y7B0|uniprotkb:Q5Y7B9|uniprotkb:Q5Y7E9|uniprotkb:Q5Y7G0|uniprotkb:Q683P7|uniprotkb:Q6REE2|uniprotkb:Q6T865|uniprotkb:Q6U387|uniprotkb:Q701T1|uniprotkb:Q70GL2|uniprotkb:Q70Q85|uniprotkb:Q768U4|uniprotkb:Q7M2H4|uniprotkb:Q7YNY9|uniprotkb:Q7YP03|uniprotkb:Q7YP04|uniprotkb:Q7YQ26|uniprotkb:Q7YQA3|uniprotkb:Q7YQA5|uniprotkb:Q860D8|uniprotkb:Q860D9|uniprotkb:Q860E5|uniprotkb:Q860H8|uniprotkb:Q860S0|uniprotkb:Q860Z3|uniprotkb:Q861G6|uniprotkb:Q861H0|uniprotkb:Q861H4|uniprotkb:Q861H5|uniprotkb:Q861H7|uniprotkb:Q861H8|uniprotkb:Q8HWQ6|uniprotkb:Q8MH59|uniprotkb:Q8MH60|uniprotkb:Q8WLU3|uniprotkb:Q8WMA0|uniprotkb:Q95348|uniprotkb:Q95383|uniprotkb:Q95389|uniprotkb:Q95461|uniprotkb:Q95HK1|uniprotkb:Q95HL0|uniprotkb:Q95HL1|uniprotkb:Q95IE3|uniprotkb:Q95IG2|uniprotkb:Q95IT6|uniprotkb:Q96HZ9|uniprotkb:Q9BCL7|uniprotkb:Q9BCP0|uniprotkb:Q9BCP1|uniprotkb:Q9BCP2|uniprotkb:Q9BCP5|uniprotkb:Q9BD21|uniprotkb:Q9BD33|uniprotkb:Q9BD40|uniprotkb:Q9GIK5|uniprotkb:Q9GIL5|uniprotkb:Q9GIL6|uniprotkb:Q9GIP3|uniprotkb:Q9GIX8|uniprotkb:Q9GIY0|uniprotkb:Q9GIY1|uniprotkb:Q9GIY2|uniprotkb:B2LVF9|uniprotkb:B2NJ29|uniprotkb:B2ZCY1|uniprotkb:B3VTP8|uniprotkb:B3VTQ3|uniprotkb:B5A8Y2|uniprotkb:B5A8Y3|uniprotkb:C0LAB5|uniprotkb:B5B8U0|uniprotkb:B5B9V5|uniprotkb:B5B9V6|uniprotkb:B5LZ25|uniprotkb:B5QSK8|uniprotkb:B6VCX2|uniprotkb:B6VEL9|uniprotkb:B7UDB2|uniprotkb:B9VRA4|uniprotkb:B9X248|uniprotkb:Q0PGR5|uniprotkb:O02876|uniprotkb:O02930|uniprotkb:O19585|uniprotkb:O19718|uniprotkb:O19788|uniprotkb:O46699|uniprotkb:O46793|uniprotkb:O46872|uniprotkb:O62869|uniprotkb:O62889|uniprotkb:O77969|uniprotkb:O78047|uniprotkb:O78210|uniprotkb:O98212|uniprotkb:P01912|uniprotkb:P01914|uniprotkb:P04229|uniprotkb:P13758|uniprotkb:P13760|uniprotkb:P13761|uniprotkb:P20039|uniprotkb:P79545|uniprotkb:Q06662|intact:EBI-3866098|intact:EBI-13953066|uniprotkb:Q9GIY3|uniprotkb:Q9GJ25|uniprotkb:Q9GJ56|uniprotkb:Q9GJ57|uniprotkb:Q9GJ58|uniprotkb:Q9GJ60|uniprotkb:Q9GJF8|uniprotkb:Q9GJF9|uniprotkb:Q9GJG0|uniprotkb:Q9MXZ0|uniprotkb:Q9MXZ5|uniprotkb:Q9MY45|uniprotkb:Q9MY56|uniprotkb:Q9MYF5|uniprotkb:Q9TPB6|uniprotkb:Q9TPW1|uniprotkb:Q9TPW3|uniprotkb:Q9TPW9|uniprotkb:Q9TPX4|uniprotkb:Q9TQ37|uniprotkb:Q9TQ91|uniprotkb:Q9TQE0|uniprotkb:Q9UBY1|uniprotkb:Q9UIM9|uniprotkb:Q9UIN0|uniprotkb:Q9XRX1|uniprotkb:Q9XRY4|uniprotkb:Q9Y453|uniprotkb:Q9Y4H7|intact:EBI-13953170|intact:EBI-2877159 psi-mi:hspa1a_hspa1b_human-1(display_short)|psi-mi:EBI-11820565(display_long) psi-mi:drb1_human(display_long)|uniprotkb:HLA-DRB1(gene name)|psi-mi:HLA-DRB1(display_short)|uniprotkb:Human leukocyte antigen DRB1(gene name synonym) psi-mi:"MI:0892"(solid phase assay) Haug et al. (2007) imex:IM-25683|pubmed:17357109 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13953401|imex:IM-25683-26 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:1304"(molecule set) psi-mi:"MI:0326"(protein) - refseq:NP_002115.2|ensembl:ENSG00000196126(gene)|ensembl:ENST00000360004(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001772"(immunological synapse)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0002469"(myeloid dendritic cell antigen processing and presentation)|go:"GO:0002491"(antigen processing and presentation of endogenous peptide antigen via MHC class II)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0002842"(positive regulation of T cell mediated immune response to tumor cell)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005615"(extracellular space)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0008544"(epidermis development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016045"(detection of bacterium)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030247"(polysaccharide binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032395"(MHC class II receptor activity)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032653"(regulation of interleukin-10 production)|go:"GO:0032673"(regulation of interleukin-4 production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032831"(positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043382"(positive regulation of memory T cell differentiation)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045622"(regulation of T-helper cell differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046598"(positive regulation of viral entry into host cell)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2000516"(positive regulation of CD4-positive, alpha-beta T cell activation)|interpro:IPR000353(MHC class II, beta chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1A6A|rcsb pdb:1AQD|rcsb pdb:1BX2|rcsb pdb:1D5M|rcsb pdb:1D5X|rcsb pdb:1D5Z|rcsb pdb:1D6E|rcsb pdb:1DLH|rcsb pdb:1FYT|rcsb pdb:1HXY|rcsb pdb:1J8H|rcsb pdb:1JWM|rcsb pdb:1JWS|rcsb pdb:1JWU|rcsb pdb:1KG0|rcsb pdb:1KLG|rcsb pdb:1KLU|rcsb pdb:1LO5|rcsb pdb:1PYW|rcsb pdb:1R5I|rcsb pdb:1SEB|rcsb pdb:1SJE|rcsb pdb:1SJH|rcsb pdb:1T5W|rcsb pdb:1T5X|rcsb pdb:1YMM|rcsb pdb:2FSE|rcsb pdb:2G9H|rcsb pdb:2IAM|rcsb pdb:2IAN|rcsb pdb:2ICW|rcsb pdb:2IPK|rcsb pdb:2OJE|rcsb pdb:2SEB|rcsb pdb:2WBJ|rcsb pdb:2XN9|rcsb pdb:3L6F|rcsb pdb:3O6F|rcsb pdb:3PDO|rcsb pdb:3PGC|rcsb pdb:3PGD|rcsb pdb:3QXA|rcsb pdb:3QXD|rcsb pdb:3S4S|rcsb pdb:3S5L|rcsb pdb:3T0E|rcsb pdb:4AEN|rcsb pdb:4AH2|rcsb pdb:4C56|rcsb pdb:4E41|rcsb pdb:4FQX|rcsb pdb:4GBX|rcsb pdb:4I5B|rcsb pdb:4IS6|rcsb pdb:4MCY|rcsb pdb:4MCZ|rcsb pdb:4MD0|rcsb pdb:4MD4|rcsb pdb:4MD5|rcsb pdb:4MDI|rcsb pdb:4MDJ|rcsb pdb:4OV5|rcsb pdb:4X5W|rcsb pdb:4X5X|rcsb pdb:4Y19|rcsb pdb:4Y1A|rcsb pdb:5JLZ|rcsb pdb:5LAX|rcsb pdb:5NI9|rcsb pdb:5NIG|rcsb pdb:6BIJ|rcsb pdb:6BIL|rcsb pdb:6BIN|rcsb pdb:6BIR|rcsb pdb:6BIV|rcsb pdb:6BIX|rcsb pdb:6BIY|rcsb pdb:6BIZ|rcsb pdb:6CPL|rcsb pdb:6CPN|rcsb pdb:6CPO|rcsb pdb:6CQJ|rcsb pdb:6CQL|rcsb pdb:6CQN|rcsb pdb:6CQQ|rcsb pdb:6CQR|rcsb pdb:6HBY|rcsb pdb:6NIX|rcsb pdb:6QZA|rcsb pdb:6QZC|rcsb pdb:6QZD|rcsb pdb:6R0E|rcsb pdb:6V0Y|rcsb pdb:6V13|rcsb pdb:6V15|rcsb pdb:6V18|rcsb pdb:6V19|rcsb pdb:6V1A|reactome:R-HSA-202424|reactome:R-HSA-202427|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-2132295|reactome:R-HSA-389948|reactome:R-HSA-877300|refseq:XP_011546040.1|refseq:NP_001230894.1 - comment:P0DMV8,P0DMV9 - figure legend:7C|comment:HLA-DRB1*0401;Inhibitor HLA-DRB1*0401|comment:The interaction of Hsp70 with complete HLA-DR molecules cannot be significantly inhibited by HV3-region peptide fragments.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/20 2020/10/15 - rogid:YdQX0KNIxO5tYjgm6hdRRZfNlk49606 - false - biotin tag:?-? - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation)