#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P30307	uniprotkb:P53350	intact:EBI-974439|ensembl:ENSP00000321656|ensembl:ENSP00000424795|uniprotkb:Q96PL3|uniprotkb:Q9H168|uniprotkb:Q9H2E8|uniprotkb:Q9H2E9|uniprotkb:Q9H2F1|uniprotkb:D3DQB8	intact:EBI-476768|uniprotkb:Q15153|uniprotkb:Q99746|ensembl:ENSP00000300093	psi-mi:mpip3_human(display_long)|uniprotkb:CDC25C(gene name)|psi-mi:CDC25C(display_short)|uniprotkb:Dual specificity phosphatase Cdc25C(gene name synonym)	psi-mi:plk1_human(display_long)|uniprotkb:Polo-like kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 13(gene name synonym)|uniprotkb:PLK1(gene name)|psi-mi:PLK1(display_short)|uniprotkb:PLK(gene name synonym)	psi-mi:"MI:0017"(classical fluorescence spectroscopy)	García-Alvarez et al. (2007)	pubmed:17307877|doi:10.1073/pnas.0609131104|imex:IM-22751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15623875|imex:IM-22751-1|dip:DIP-70366E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000158402(gene)|ensembl:ENST00000323760(transcript)|ensembl:ENST00000513970(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050699"(WW domain binding)|go:"GO:0051301"(cell division)|go:"GO:0110032"(positive regulation of G2/MI transition of meiotic cell cycle)|interpro:IPR000751(M-phase inducer phosphatase)|interpro:IPR001763(Rhodanese-like)|interpro:IPR036873|mint:P30307|rcsb pdb:2OJX|rcsb pdb:3BZI|rcsb pdb:3OP3|rcsb pdb:5M35|rcsb pdb:5M36|rcsb pdb:5M37|reactome:R-HSA-156711|reactome:R-HSA-176187|reactome:R-HSA-5625740|reactome:R-HSA-6804114|reactome:R-HSA-6804115|reactome:R-HSA-69273|reactome:R-HSA-75035|reactome:R-HSA-8862803|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|refseq:NP_001781.2|refseq:NP_073720.1|refseq:NP_001305027.1|refseq:XP_011542064.1|refseq:NP_001274511.1|dip:DIP-24183N	refseq:NP_005021.2|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0045143"(homologous chromosome segregation)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0051081"(nuclear membrane disassembly)|go:"GO:0051233"(spindle midzone)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070194"(synaptonemal complex disassembly)|go:"GO:0071168"(protein localization to chromatin)|go:"GO:0090435"(protein localization to nuclear envelope)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901673"(regulation of mitotic spindle assembly)|go:"GO:1901990"(regulation of mitotic cell cycle phase transition)|ensembl:ENSG00000166851(gene)|ensembl:ENST00000300093(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000776"(kinetochore)|go:"GO:0000785"(chromatin)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0000922"(spindle pole)|go:"GO:0000940"(outer kinetochore)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007076"(mitotic chromosome condensation)|go:"GO:0007077"(mitotic nuclear membrane disassembly)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0005524"(ATP binding)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008017"(microtubule binding)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016321"(female meiosis chromosome segregation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030071"(regulation of mitotic metaphase/anaphase transition)|go:"GO:0030496"(midbody)|go:"GO:0031648"(protein destabilization)|rcsb pdb:4DFW|rcsb pdb:4E67|rcsb pdb:4E9C|rcsb pdb:4E9D|rcsb pdb:4H5X|rcsb pdb:4H71|rcsb pdb:4HAB|rcsb pdb:4HCO|rcsb pdb:4HY2|rcsb pdb:4J52|rcsb pdb:4J53|rcsb pdb:4LKL|rcsb pdb:4LKM|rcsb pdb:4O56|rcsb pdb:4O6W|rcsb pdb:4O9W|rcsb pdb:4RCP|rcsb pdb:4WHH|rcsb pdb:4WHK|rcsb pdb:4WHL|rcsb pdb:4X9R|rcsb pdb:4X9V|rcsb pdb:4X9W|rcsb pdb:5J19|rcsb pdb:5NEI|rcsb pdb:5NFU|rcsb pdb:5NJE|rcsb pdb:5NMM|rcsb pdb:5NN1|rcsb pdb:5NN2|rcsb pdb:5TA6|rcsb pdb:5TA8|rcsb pdb:6AX4|rcsb pdb:6GY2|reactome:R-HSA-141444|reactome:R-HSA-156711|reactome:R-HSA-162658|reactome:R-HSA-174178|reactome:R-HSA-176412|reactome:R-HSA-176417|reactome:R-HSA-2299718|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-2565942|reactome:R-HSA-2980767|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-68881|reactome:R-HSA-68884|reactome:R-HSA-69273|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-9648025|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1904776"(regulation of protein localization to cell cortex)|go:"GO:1905784"(regulation of anaphase-promoting complex-dependent catabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000959(POLO box duplicated region)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033695|interpro:IPR033701|interpro:IPR033702|interpro:IPR036947|mint:P53350|rcsb pdb:1Q4K|rcsb pdb:1Q4O|rcsb pdb:1UMW|rcsb pdb:2OGQ|rcsb pdb:2OJX|rcsb pdb:2OU7|rcsb pdb:2OWB|rcsb pdb:2RKU|rcsb pdb:2V5Q|rcsb pdb:2YAC|rcsb pdb:3BZI|rcsb pdb:3C5L|rcsb pdb:3FC2|rcsb pdb:3FVH|rcsb pdb:3HIH|rcsb pdb:3HIK|rcsb pdb:3KB7|rcsb pdb:3P2W|rcsb pdb:3P2Z|rcsb pdb:3P34|rcsb pdb:3P35|rcsb pdb:3P36|rcsb pdb:3P37|rcsb pdb:3Q1I|rcsb pdb:3RQ7|rcsb pdb:3THB|rcsb pdb:4A4L|rcsb pdb:4A4O|dip:DIP-29696N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:YzNTFdiRdWfd4n69U13LgJU5DOs9606	rogid:fBOK366hV6mDprx9IWhz43gPcJE9606	rigid:FQvhus+pzN3KiCne8ghRh8FjeDk	false	sufficient binding region:126-134	sufficient binding region:367-603	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P30307	uniprotkb:P53350	intact:EBI-974439|ensembl:ENSP00000321656|ensembl:ENSP00000424795|uniprotkb:Q96PL3|uniprotkb:Q9H168|uniprotkb:Q9H2E8|uniprotkb:Q9H2E9|uniprotkb:Q9H2F1|uniprotkb:D3DQB8	intact:EBI-476768|uniprotkb:Q15153|uniprotkb:Q99746|ensembl:ENSP00000300093	psi-mi:mpip3_human(display_long)|uniprotkb:CDC25C(gene name)|psi-mi:CDC25C(display_short)|uniprotkb:Dual specificity phosphatase Cdc25C(gene name synonym)	psi-mi:plk1_human(display_long)|uniprotkb:Polo-like kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 13(gene name synonym)|uniprotkb:PLK1(gene name)|psi-mi:PLK1(display_short)|uniprotkb:PLK(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	García-Alvarez et al. (2007)	pubmed:17307877|doi:10.1073/pnas.0609131104|imex:IM-22751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15623898|imex:IM-22751-2|dip:DIP-70366E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000158402(gene)|ensembl:ENST00000323760(transcript)|ensembl:ENST00000513970(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050699"(WW domain binding)|go:"GO:0051301"(cell division)|go:"GO:0110032"(positive regulation of G2/MI transition of meiotic cell cycle)|interpro:IPR000751(M-phase inducer phosphatase)|interpro:IPR001763(Rhodanese-like)|interpro:IPR036873|mint:P30307|rcsb pdb:2OJX|rcsb pdb:3BZI|rcsb pdb:3OP3|rcsb pdb:5M35|rcsb pdb:5M36|rcsb pdb:5M37|reactome:R-HSA-156711|reactome:R-HSA-176187|reactome:R-HSA-5625740|reactome:R-HSA-6804114|reactome:R-HSA-6804115|reactome:R-HSA-69273|reactome:R-HSA-75035|reactome:R-HSA-8862803|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|refseq:NP_001781.2|refseq:NP_073720.1|refseq:NP_001305027.1|refseq:XP_011542064.1|refseq:NP_001274511.1|dip:DIP-24183N	refseq:NP_005021.2|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0045143"(homologous chromosome segregation)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0051081"(nuclear membrane disassembly)|go:"GO:0051233"(spindle midzone)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070194"(synaptonemal complex disassembly)|go:"GO:0071168"(protein localization to chromatin)|go:"GO:0090435"(protein localization to nuclear envelope)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901673"(regulation of mitotic spindle assembly)|go:"GO:1901990"(regulation of mitotic cell cycle phase transition)|ensembl:ENSG00000166851(gene)|ensembl:ENST00000300093(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000776"(kinetochore)|go:"GO:0000785"(chromatin)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0000922"(spindle pole)|go:"GO:0000940"(outer kinetochore)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007076"(mitotic chromosome condensation)|go:"GO:0007077"(mitotic nuclear membrane disassembly)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0005524"(ATP binding)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008017"(microtubule binding)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016321"(female meiosis chromosome segregation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030071"(regulation of mitotic metaphase/anaphase transition)|go:"GO:0030496"(midbody)|go:"GO:0031648"(protein destabilization)|rcsb pdb:4DFW|rcsb pdb:4E67|rcsb pdb:4E9C|rcsb pdb:4E9D|rcsb pdb:4H5X|rcsb pdb:4H71|rcsb pdb:4HAB|rcsb pdb:4HCO|rcsb pdb:4HY2|rcsb pdb:4J52|rcsb pdb:4J53|rcsb pdb:4LKL|rcsb pdb:4LKM|rcsb pdb:4O56|rcsb pdb:4O6W|rcsb pdb:4O9W|rcsb pdb:4RCP|rcsb pdb:4WHH|rcsb pdb:4WHK|rcsb pdb:4WHL|rcsb pdb:4X9R|rcsb pdb:4X9V|rcsb pdb:4X9W|rcsb pdb:5J19|rcsb pdb:5NEI|rcsb pdb:5NFU|rcsb pdb:5NJE|rcsb pdb:5NMM|rcsb pdb:5NN1|rcsb pdb:5NN2|rcsb pdb:5TA6|rcsb pdb:5TA8|rcsb pdb:6AX4|rcsb pdb:6GY2|reactome:R-HSA-141444|reactome:R-HSA-156711|reactome:R-HSA-162658|reactome:R-HSA-174178|reactome:R-HSA-176412|reactome:R-HSA-176417|reactome:R-HSA-2299718|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-2565942|reactome:R-HSA-2980767|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-68881|reactome:R-HSA-68884|reactome:R-HSA-69273|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-9648025|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1904776"(regulation of protein localization to cell cortex)|go:"GO:1905784"(regulation of anaphase-promoting complex-dependent catabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000959(POLO box duplicated region)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033695|interpro:IPR033701|interpro:IPR033702|interpro:IPR036947|mint:P53350|rcsb pdb:1Q4K|rcsb pdb:1Q4O|rcsb pdb:1UMW|rcsb pdb:2OGQ|rcsb pdb:2OJX|rcsb pdb:2OU7|rcsb pdb:2OWB|rcsb pdb:2RKU|rcsb pdb:2V5Q|rcsb pdb:2YAC|rcsb pdb:3BZI|rcsb pdb:3C5L|rcsb pdb:3FC2|rcsb pdb:3FVH|rcsb pdb:3HIH|rcsb pdb:3HIK|rcsb pdb:3KB7|rcsb pdb:3P2W|rcsb pdb:3P2Z|rcsb pdb:3P34|rcsb pdb:3P35|rcsb pdb:3P36|rcsb pdb:3P37|rcsb pdb:3Q1I|rcsb pdb:3RQ7|rcsb pdb:3THB|rcsb pdb:4A4L|rcsb pdb:4A4O|dip:DIP-29696N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:YzNTFdiRdWfd4n69U13LgJU5DOs9606	rogid:fBOK366hV6mDprx9IWhz43gPcJE9606	rigid:FQvhus+pzN3KiCne8ghRh8FjeDk	false	sufficient binding region:126-134	sufficient binding region:367-603	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P30307	uniprotkb:P53350	intact:EBI-974439|ensembl:ENSP00000321656|ensembl:ENSP00000424795|uniprotkb:Q96PL3|uniprotkb:Q9H168|uniprotkb:Q9H2E8|uniprotkb:Q9H2E9|uniprotkb:Q9H2F1|uniprotkb:D3DQB8	intact:EBI-476768|uniprotkb:Q15153|uniprotkb:Q99746|ensembl:ENSP00000300093	psi-mi:mpip3_human(display_long)|uniprotkb:CDC25C(gene name)|psi-mi:CDC25C(display_short)|uniprotkb:Dual specificity phosphatase Cdc25C(gene name synonym)	psi-mi:plk1_human(display_long)|uniprotkb:Polo-like kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 13(gene name synonym)|uniprotkb:PLK1(gene name)|psi-mi:PLK1(display_short)|uniprotkb:PLK(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	García-Alvarez et al. (2007)	pubmed:17307877|doi:10.1073/pnas.0609131104|imex:IM-22751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15623919|imex:IM-22751-3|dip:DIP-70366E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000158402(gene)|ensembl:ENST00000323760(transcript)|ensembl:ENST00000513970(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050699"(WW domain binding)|go:"GO:0051301"(cell division)|go:"GO:0110032"(positive regulation of G2/MI transition of meiotic cell cycle)|interpro:IPR000751(M-phase inducer phosphatase)|interpro:IPR001763(Rhodanese-like)|interpro:IPR036873|mint:P30307|rcsb pdb:2OJX|rcsb pdb:3BZI|rcsb pdb:3OP3|rcsb pdb:5M35|rcsb pdb:5M36|rcsb pdb:5M37|reactome:R-HSA-156711|reactome:R-HSA-176187|reactome:R-HSA-5625740|reactome:R-HSA-6804114|reactome:R-HSA-6804115|reactome:R-HSA-69273|reactome:R-HSA-75035|reactome:R-HSA-8862803|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|refseq:NP_001781.2|refseq:NP_073720.1|refseq:NP_001305027.1|refseq:XP_011542064.1|refseq:NP_001274511.1|dip:DIP-24183N	refseq:NP_005021.2|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0045143"(homologous chromosome segregation)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0051081"(nuclear membrane disassembly)|go:"GO:0051233"(spindle midzone)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070194"(synaptonemal complex disassembly)|go:"GO:0071168"(protein localization to chromatin)|go:"GO:0090435"(protein localization to nuclear envelope)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901673"(regulation of mitotic spindle assembly)|go:"GO:1901990"(regulation of mitotic cell cycle phase transition)|ensembl:ENSG00000166851(gene)|ensembl:ENST00000300093(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000776"(kinetochore)|go:"GO:0000785"(chromatin)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0000922"(spindle pole)|go:"GO:0000940"(outer kinetochore)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007076"(mitotic chromosome condensation)|go:"GO:0007077"(mitotic nuclear membrane disassembly)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0005524"(ATP binding)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008017"(microtubule binding)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016321"(female meiosis chromosome segregation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030071"(regulation of mitotic metaphase/anaphase transition)|go:"GO:0030496"(midbody)|go:"GO:0031648"(protein destabilization)|rcsb pdb:4DFW|rcsb pdb:4E67|rcsb pdb:4E9C|rcsb pdb:4E9D|rcsb pdb:4H5X|rcsb pdb:4H71|rcsb pdb:4HAB|rcsb pdb:4HCO|rcsb pdb:4HY2|rcsb pdb:4J52|rcsb pdb:4J53|rcsb pdb:4LKL|rcsb pdb:4LKM|rcsb pdb:4O56|rcsb pdb:4O6W|rcsb pdb:4O9W|rcsb pdb:4RCP|rcsb pdb:4WHH|rcsb pdb:4WHK|rcsb pdb:4WHL|rcsb pdb:4X9R|rcsb pdb:4X9V|rcsb pdb:4X9W|rcsb pdb:5J19|rcsb pdb:5NEI|rcsb pdb:5NFU|rcsb pdb:5NJE|rcsb pdb:5NMM|rcsb pdb:5NN1|rcsb pdb:5NN2|rcsb pdb:5TA6|rcsb pdb:5TA8|rcsb pdb:6AX4|rcsb pdb:6GY2|reactome:R-HSA-141444|reactome:R-HSA-156711|reactome:R-HSA-162658|reactome:R-HSA-174178|reactome:R-HSA-176412|reactome:R-HSA-176417|reactome:R-HSA-2299718|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-2565942|reactome:R-HSA-2980767|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-68881|reactome:R-HSA-68884|reactome:R-HSA-69273|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-9648025|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1904776"(regulation of protein localization to cell cortex)|go:"GO:1905784"(regulation of anaphase-promoting complex-dependent catabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000959(POLO box duplicated region)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033695|interpro:IPR033701|interpro:IPR033702|interpro:IPR036947|mint:P53350|rcsb pdb:1Q4K|rcsb pdb:1Q4O|rcsb pdb:1UMW|rcsb pdb:2OGQ|rcsb pdb:2OJX|rcsb pdb:2OU7|rcsb pdb:2OWB|rcsb pdb:2RKU|rcsb pdb:2V5Q|rcsb pdb:2YAC|rcsb pdb:3BZI|rcsb pdb:3C5L|rcsb pdb:3FC2|rcsb pdb:3FVH|rcsb pdb:3HIH|rcsb pdb:3HIK|rcsb pdb:3KB7|rcsb pdb:3P2W|rcsb pdb:3P2Z|rcsb pdb:3P34|rcsb pdb:3P35|rcsb pdb:3P36|rcsb pdb:3P37|rcsb pdb:3Q1I|rcsb pdb:3RQ7|rcsb pdb:3THB|rcsb pdb:4A4L|rcsb pdb:4A4O|dip:DIP-29696N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:YzNTFdiRdWfd4n69U13LgJU5DOs9606	rogid:fBOK366hV6mDprx9IWhz43gPcJE9606	rigid:FQvhus+pzN3KiCne8ghRh8FjeDk	false	sufficient binding region:126-134	sufficient binding region:367-603|mutation disrupting interaction strength:414-414	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)