#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P25976 uniprotkb:Q08775 intact:EBI-7364139|intact:MINT-4084181 intact:EBI-903354|uniprotkb:O35183|uniprotkb:Q08776|uniprotkb:Q9JLN0|uniprotkb:Q9QUQ6|uniprotkb:Q9QY29|uniprotkb:Q9R0U4|uniprotkb:Q9Z2J7 psi-mi:ubf1_mouse(display_long)|uniprotkb:Ubtf(gene name)|psi-mi:Ubtf(display_short)|uniprotkb:Tcfubf(gene name synonym)|uniprotkb:Ubf1(gene name synonym)|uniprotkb:Ubf-1(gene name synonym)|uniprotkb:Upstream-binding factor 1(gene name synonym) psi-mi:runx2_mouse(display_long)|uniprotkb:Runx2(gene name)|psi-mi:Runx2(display_short)|uniprotkb:Aml3(gene name synonym)|uniprotkb:Cbfa1(gene name synonym)|uniprotkb:Osf2(gene name synonym)|uniprotkb:Pebp2a(gene name synonym)|uniprotkb:Core-binding factor subunit alpha-1(gene name synonym)|uniprotkb:Acute myeloid leukemia 3 protein(gene name synonym)|uniprotkb:Oncogene AML-3(gene name synonym)|uniprotkb:Polyomavirus enhancer-binding protein 2 alpha A subunit(gene name synonym)|uniprotkb:SL3-3 enhancer factor 1 alpha A subunit(gene name synonym)|uniprotkb:SL3/AKV core-binding factor alpha A subunit(gene name synonym)|uniprotkb:Osteoblast-specific transcription factor 2(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Young et al. (2007) pubmed:17251981|doi:10.1038/nature05473|imex:IM-21191 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15620014|imex:IM-21191-1|dip:DIP-191088E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:P25976|go:"GO:0001164"(RNA polymerase I core promoter sequence-specific DNA binding)|go:"GO:0001165"(RNA polymerase I cis-regulatory region sequence-specific DNA binding)|go:"GO:0001181"(RNA polymerase I general transcription initiation factor activity)|go:"GO:0001650"(fibrillar center)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0006360"(transcription by RNA polymerase I)|go:"GO:0006361"(transcription initiation from RNA polymerase I promoter)|go:"GO:0006362"(transcription elongation from RNA polymerase I promoter)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR029215|interpro:IPR036910|rcsb pdb:1V63|rcsb pdb:1V64|rcsb pdb:1WGF|reactome:R-MMU-73728|reactome:R-MMU-73762|reactome:R-MMU-73772|reactome:R-MMU-73863|dip:DIP-29977N refseq:NP_001139510.1|refseq:NP_033950.2|refseq:NP_001258556.1|refseq:XP_006523607.1|refseq:XP_006523608.1|mint:Q08775|dip:DIP-36316N|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0040036"(regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042487"(regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048469"(cell maturation)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0140296"(general transcription initiation factor binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000040("Acute myeloid leukemia 1 protein (AML 1)/Runt")|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013524("Acute myeloid leukemia 1 (AML 1)/Runt")|interpro:IPR013711(Runx inhibition)|interpro:IPR027384|reactome:R-MMU-8878166|reactome:R-MMU-8939902|reactome:R-MMU-8940973|reactome:R-MMU-8941326|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001501"(skeletal system development)|go:"GO:0001503"(ossification)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001958"(endochondral ossification)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002063"(chondrocyte development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030509"(BMP signaling pathway) psi-mi:"MI:0465"(dip) comment:mint|function:UBF recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I through cooperative interactions with the species-specific factor SL1. It binds specifically to the upstream control element - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse)|taxid:10090(Mus musculus) - 2017/08/05 2017/08/10 rogid:TJRBUUHHZDYhIRdbtsijzuOSbAo10090 rogid:WYs7JxHzJasUS7fx5/LzgKJEjEY10090 rigid:dkoxgCwbawmRBXaWmmg9j30XTm8 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q13950 uniprotkb:P17480 intact:EBI-976402|intact:EBI-28971669|ensembl:ENSP00000360493|ensembl:ENSP00000495497|uniprotkb:O14614|uniprotkb:O14615|uniprotkb:O95181 intact:EBI-396235|uniprotkb:A8K6R8|ensembl:ENSP00000302640|ensembl:ENSP00000390669|ensembl:ENSP00000435708 psi-mi:runx2_human(display_long)|uniprotkb:Oncogene AML-3(gene name synonym)|uniprotkb:Polyomavirus enhancer-binding protein 2 alpha A subunit(gene name synonym)|uniprotkb:SL3-3 enhancer factor 1 alpha A subunit(gene name synonym)|uniprotkb:SL3/AKV core-binding factor alpha A subunit(gene name synonym)|uniprotkb:Osteoblast-specific transcription factor 2(gene name synonym)|uniprotkb:Core-binding factor subunit alpha-1(gene name synonym)|uniprotkb:Acute myeloid leukemia 3 protein(gene name synonym)|uniprotkb:RUNX2(gene name)|psi-mi:RUNX2(display_short)|uniprotkb:AML3(gene name synonym)|uniprotkb:CBFA1(gene name synonym)|uniprotkb:OSF2(gene name synonym)|uniprotkb:PEBP2A(gene name synonym) psi-mi:ubf1_human(display_long)|uniprotkb:UBTF(gene name)|psi-mi:UBTF(display_short)|uniprotkb:UBF(gene name synonym)|uniprotkb:UBF1(gene name synonym)|uniprotkb:Upstream-binding factor 1(gene name synonym)|uniprotkb:Autoantigen NOR-90(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Young et al. (2007) pubmed:17251981|doi:10.1038/nature05473|imex:IM-21191 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15620031|imex:IM-21191-2|dip:DIP-189063E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000359524|ensembl:ENSP00000352514|ensembl:ENST00000371432|ensembl:ENSP00000360486|ensembl:ENST00000371436|ensembl:ENSP00000360491|ensembl:ENSP00000360493|ensembl:ENSP00000495497|ensembl:ENSG00000124813(gene)|ensembl:ENST00000371438(transcript)|ensembl:ENST00000647337(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001503"(ossification)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001958"(endochondral ossification)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002063"(chondrocyte development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048469"(cell maturation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000040("Acute myeloid leukemia 1 protein (AML 1)/Runt")|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013524("Acute myeloid leukemia 1 (AML 1)/Runt")|interpro:IPR013711(Runx inhibition)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0035115"(embryonic forelimb morphogenesis)|interpro:IPR016554(Transcription factor, Runt-related, RUNX)|go:"GO:0040036"(regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|interpro:IPR027384|mint:Q13950|go:"GO:0042487"(regulation of odontogenesis of dentin-containing tooth)|go:"GO:0043425"(bHLH transcription factor binding)|rcsb pdb:6VG8|rcsb pdb:6VGD|rcsb pdb:6VGE|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|rcsb pdb:6VGG|reactome:R-HSA-2032785|reactome:R-HSA-8878166|reactome:R-HSA-8939246|reactome:R-HSA-8939902|reactome:R-HSA-8940973|reactome:R-HSA-8941284|reactome:R-HSA-8941326|reactome:R-HSA-8941332|reactome:R-HSA-8941333|refseq:NP_001015051.3|refseq:NP_001019801.3|dip:DIP-36707N refseq:NP_001070151.1|refseq:NP_001070152.1|refseq:NP_055048.1|refseq:XP_006722122.1|refseq:XP_006722123.1|refseq:XP_006722124.1|refseq:XP_016880492.1|refseq:XP_016880493.1|dip:DIP-640N|ensembl:ENSG00000108312(gene)|ensembl:ENST00000302904(transcript)|ensembl:ENST00000436088(transcript)|ensembl:ENST00000529383(transcript)|go:"GO:0001164"(RNA polymerase I core promoter sequence-specific DNA binding)|go:"GO:0001165"(RNA polymerase I cis-regulatory region sequence-specific DNA binding)|go:"GO:0001181"(RNA polymerase I general transcription initiation factor activity)|go:"GO:0001650"(fibrillar center)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006360"(transcription by RNA polymerase I)|go:"GO:0006361"(transcription initiation from RNA polymerase I promoter)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0097110"(scaffold protein binding)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR029215|interpro:IPR036910|mint:P17480|rcsb pdb:1K99|rcsb pdb:1L8Y|rcsb pdb:1L8Z|rcsb pdb:2HDZ|reactome:R-HSA-427413|reactome:R-HSA-73728|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73863 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/05 2017/08/10 rogid:aUhn8jpJsl5oS4kMBgUYdpncy6Y9606 rogid:uHwgY0OFREKv8MdMOMpREDgUEI89606 rigid:ivB4vGT9oYW321fd6YE7fygEooQ false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P25976 uniprotkb:P97357 intact:EBI-7364139|intact:MINT-4084181 intact:EBI-15620048|ensembl:ENSMUSP00000142213 psi-mi:ubf1_mouse(display_long)|uniprotkb:Ubtf(gene name)|psi-mi:Ubtf(display_short)|uniprotkb:Tcfubf(gene name synonym)|uniprotkb:Ubf1(gene name synonym)|uniprotkb:Ubf-1(gene name synonym)|uniprotkb:Upstream-binding factor 1(gene name synonym) psi-mi:taf1a_mouse(display_long)|uniprotkb:Taf1a(gene name)|psi-mi:Taf1a(display_short)|uniprotkb:RNA polymerase I-specific TBP-associated factor 48 kDa(gene name synonym)|uniprotkb:TATA box-binding protein-associated factor 1A(gene name synonym)|uniprotkb:Transcription initiation factor SL1/TIF-IB subunit A(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Young et al. (2007) pubmed:17251981|doi:10.1038/nature05473|imex:IM-21191 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15620074|imex:IM-21191-3|dip:DIP-191087E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:P25976|go:"GO:0001164"(RNA polymerase I core promoter sequence-specific DNA binding)|go:"GO:0001165"(RNA polymerase I cis-regulatory region sequence-specific DNA binding)|go:"GO:0001181"(RNA polymerase I general transcription initiation factor activity)|go:"GO:0001650"(fibrillar center)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0006360"(transcription by RNA polymerase I)|go:"GO:0006361"(transcription initiation from RNA polymerase I promoter)|go:"GO:0006362"(transcription elongation from RNA polymerase I promoter)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR029215|interpro:IPR036910|rcsb pdb:1V63|rcsb pdb:1V64|rcsb pdb:1WGF|reactome:R-MMU-73728|reactome:R-MMU-73762|reactome:R-MMU-73772|reactome:R-MMU-73863|dip:DIP-29977N ensembl:ENSMUSG00000072258(gene)|ensembl:ENSMUST00000192076(transcript)|go:"GO:0000120"(RNA polymerase I transcription regulator complex)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006360"(transcription by RNA polymerase I)|go:"GO:0015630"(microtubule cytoskeleton)|interpro:IPR016629("RNA polymerase I, subunit A (TATA-binding protein-associated factor)")|interpro:IPR039495|reactome:R-MMU-5250924|reactome:R-MMU-73762|reactome:R-MMU-73772|reactome:R-MMU-73863|refseq:NP_001264886.1|refseq:NP_001264887.1|refseq:NP_001264888.1|refseq:NP_067441.1|dip:DIP-60267N psi-mi:"MI:0465"(dip) comment:mint|function:UBF recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I through cooperative interactions with the species-specific factor SL1. It binds specifically to the upstream control element - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse)|taxid:10090(Mus musculus) - 2017/08/05 2017/08/10 rogid:TJRBUUHHZDYhIRdbtsijzuOSbAo10090 rogid:Et2wsxzqVgyRXLm4aZh5af/blMY10090 rigid:TeCci/VxbIgMKbiviy8KuO/lwW8 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P25976 uniprotkb:Q08775 intact:EBI-7364139|intact:MINT-4084181 intact:EBI-903354|uniprotkb:O35183|uniprotkb:Q08776|uniprotkb:Q9JLN0|uniprotkb:Q9QUQ6|uniprotkb:Q9QY29|uniprotkb:Q9R0U4|uniprotkb:Q9Z2J7 psi-mi:ubf1_mouse(display_long)|uniprotkb:Ubtf(gene name)|psi-mi:Ubtf(display_short)|uniprotkb:Tcfubf(gene name synonym)|uniprotkb:Ubf1(gene name synonym)|uniprotkb:Ubf-1(gene name synonym)|uniprotkb:Upstream-binding factor 1(gene name synonym) psi-mi:runx2_mouse(display_long)|uniprotkb:Runx2(gene name)|psi-mi:Runx2(display_short)|uniprotkb:Aml3(gene name synonym)|uniprotkb:Cbfa1(gene name synonym)|uniprotkb:Osf2(gene name synonym)|uniprotkb:Pebp2a(gene name synonym)|uniprotkb:Core-binding factor subunit alpha-1(gene name synonym)|uniprotkb:Acute myeloid leukemia 3 protein(gene name synonym)|uniprotkb:Oncogene AML-3(gene name synonym)|uniprotkb:Polyomavirus enhancer-binding protein 2 alpha A subunit(gene name synonym)|uniprotkb:SL3-3 enhancer factor 1 alpha A subunit(gene name synonym)|uniprotkb:SL3/AKV core-binding factor alpha A subunit(gene name synonym)|uniprotkb:Osteoblast-specific transcription factor 2(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Young et al. (2007) pubmed:17251981|doi:10.1038/nature05473|imex:IM-21191 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15620074|imex:IM-21191-3|dip:DIP-191087E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:P25976|go:"GO:0001164"(RNA polymerase I core promoter sequence-specific DNA binding)|go:"GO:0001165"(RNA polymerase I cis-regulatory region sequence-specific DNA binding)|go:"GO:0001181"(RNA polymerase I general transcription initiation factor activity)|go:"GO:0001650"(fibrillar center)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0006360"(transcription by RNA polymerase I)|go:"GO:0006361"(transcription initiation from RNA polymerase I promoter)|go:"GO:0006362"(transcription elongation from RNA polymerase I promoter)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR029215|interpro:IPR036910|rcsb pdb:1V63|rcsb pdb:1V64|rcsb pdb:1WGF|reactome:R-MMU-73728|reactome:R-MMU-73762|reactome:R-MMU-73772|reactome:R-MMU-73863|dip:DIP-29977N refseq:NP_001139510.1|refseq:NP_033950.2|refseq:NP_001258556.1|refseq:XP_006523607.1|refseq:XP_006523608.1|mint:Q08775|dip:DIP-36316N|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0040036"(regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042487"(regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048469"(cell maturation)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0140296"(general transcription initiation factor binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000040("Acute myeloid leukemia 1 protein (AML 1)/Runt")|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013524("Acute myeloid leukemia 1 (AML 1)/Runt")|interpro:IPR013711(Runx inhibition)|interpro:IPR027384|reactome:R-MMU-8878166|reactome:R-MMU-8939902|reactome:R-MMU-8940973|reactome:R-MMU-8941326|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001501"(skeletal system development)|go:"GO:0001503"(ossification)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001958"(endochondral ossification)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002063"(chondrocyte development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030509"(BMP signaling pathway) psi-mi:"MI:0465"(dip) comment:mint|function:UBF recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I through cooperative interactions with the species-specific factor SL1. It binds specifically to the upstream control element - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse)|taxid:10090(Mus musculus) - 2017/08/05 2017/08/10 rogid:TJRBUUHHZDYhIRdbtsijzuOSbAo10090 rogid:WYs7JxHzJasUS7fx5/LzgKJEjEY10090 rigid:TeCci/VxbIgMKbiviy8KuO/lwW8 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P25976 uniprotkb:Q08775 intact:EBI-7364139|intact:MINT-4084181 intact:EBI-903354|uniprotkb:O35183|uniprotkb:Q08776|uniprotkb:Q9JLN0|uniprotkb:Q9QUQ6|uniprotkb:Q9QY29|uniprotkb:Q9R0U4|uniprotkb:Q9Z2J7 psi-mi:ubf1_mouse(display_long)|uniprotkb:Ubtf(gene name)|psi-mi:Ubtf(display_short)|uniprotkb:Tcfubf(gene name synonym)|uniprotkb:Ubf1(gene name synonym)|uniprotkb:Ubf-1(gene name synonym)|uniprotkb:Upstream-binding factor 1(gene name synonym) psi-mi:runx2_mouse(display_long)|uniprotkb:Runx2(gene name)|psi-mi:Runx2(display_short)|uniprotkb:Aml3(gene name synonym)|uniprotkb:Cbfa1(gene name synonym)|uniprotkb:Osf2(gene name synonym)|uniprotkb:Pebp2a(gene name synonym)|uniprotkb:Core-binding factor subunit alpha-1(gene name synonym)|uniprotkb:Acute myeloid leukemia 3 protein(gene name synonym)|uniprotkb:Oncogene AML-3(gene name synonym)|uniprotkb:Polyomavirus enhancer-binding protein 2 alpha A subunit(gene name synonym)|uniprotkb:SL3-3 enhancer factor 1 alpha A subunit(gene name synonym)|uniprotkb:SL3/AKV core-binding factor alpha A subunit(gene name synonym)|uniprotkb:Osteoblast-specific transcription factor 2(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Young et al. (2007) pubmed:17251981|doi:10.1038/nature05473|imex:IM-21191 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15620092|imex:IM-21191-4|dip:DIP-191088E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:P25976|go:"GO:0001164"(RNA polymerase I core promoter sequence-specific DNA binding)|go:"GO:0001165"(RNA polymerase I cis-regulatory region sequence-specific DNA binding)|go:"GO:0001181"(RNA polymerase I general transcription initiation factor activity)|go:"GO:0001650"(fibrillar center)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0006360"(transcription by RNA polymerase I)|go:"GO:0006361"(transcription initiation from RNA polymerase I promoter)|go:"GO:0006362"(transcription elongation from RNA polymerase I promoter)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR029215|interpro:IPR036910|rcsb pdb:1V63|rcsb pdb:1V64|rcsb pdb:1WGF|reactome:R-MMU-73728|reactome:R-MMU-73762|reactome:R-MMU-73772|reactome:R-MMU-73863|dip:DIP-29977N refseq:NP_001139510.1|refseq:NP_033950.2|refseq:NP_001258556.1|refseq:XP_006523607.1|refseq:XP_006523608.1|mint:Q08775|dip:DIP-36316N|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0040036"(regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042487"(regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048469"(cell maturation)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0140296"(general transcription initiation factor binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000040("Acute myeloid leukemia 1 protein (AML 1)/Runt")|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013524("Acute myeloid leukemia 1 (AML 1)/Runt")|interpro:IPR013711(Runx inhibition)|interpro:IPR027384|reactome:R-MMU-8878166|reactome:R-MMU-8939902|reactome:R-MMU-8940973|reactome:R-MMU-8941326|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001501"(skeletal system development)|go:"GO:0001503"(ossification)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001958"(endochondral ossification)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002063"(chondrocyte development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030509"(BMP signaling pathway) psi-mi:"MI:0465"(dip) comment:mint|function:UBF recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I through cooperative interactions with the species-specific factor SL1. It binds specifically to the upstream control element - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse)|taxid:10090(Mus musculus) - 2017/08/05 2017/08/10 rogid:TJRBUUHHZDYhIRdbtsijzuOSbAo10090 rogid:WYs7JxHzJasUS7fx5/LzgKJEjEY10090 rigid:dkoxgCwbawmRBXaWmmg9j30XTm8 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q08775 uniprotkb:P25976 intact:EBI-903354|uniprotkb:O35183|uniprotkb:Q08776|uniprotkb:Q9JLN0|uniprotkb:Q9QUQ6|uniprotkb:Q9QY29|uniprotkb:Q9R0U4|uniprotkb:Q9Z2J7 intact:EBI-7364139|intact:MINT-4084181 psi-mi:runx2_mouse(display_long)|uniprotkb:Runx2(gene name)|psi-mi:Runx2(display_short)|uniprotkb:Aml3(gene name synonym)|uniprotkb:Cbfa1(gene name synonym)|uniprotkb:Osf2(gene name synonym)|uniprotkb:Pebp2a(gene name synonym)|uniprotkb:Core-binding factor subunit alpha-1(gene name synonym)|uniprotkb:Acute myeloid leukemia 3 protein(gene name synonym)|uniprotkb:Oncogene AML-3(gene name synonym)|uniprotkb:Polyomavirus enhancer-binding protein 2 alpha A subunit(gene name synonym)|uniprotkb:SL3-3 enhancer factor 1 alpha A subunit(gene name synonym)|uniprotkb:SL3/AKV core-binding factor alpha A subunit(gene name synonym)|uniprotkb:Osteoblast-specific transcription factor 2(gene name synonym) psi-mi:ubf1_mouse(display_long)|uniprotkb:Ubtf(gene name)|psi-mi:Ubtf(display_short)|uniprotkb:Tcfubf(gene name synonym)|uniprotkb:Ubf1(gene name synonym)|uniprotkb:Ubf-1(gene name synonym)|uniprotkb:Upstream-binding factor 1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Young et al. (2007) pubmed:17251981|doi:10.1038/nature05473|imex:IM-21191 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15620109|imex:IM-21191-5|dip:DIP-191087E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001139510.1|refseq:NP_033950.2|refseq:NP_001258556.1|refseq:XP_006523607.1|refseq:XP_006523608.1|mint:Q08775|dip:DIP-36316N|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0040036"(regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042487"(regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048469"(cell maturation)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0140296"(general transcription initiation factor binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000040("Acute myeloid leukemia 1 protein (AML 1)/Runt")|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013524("Acute myeloid leukemia 1 (AML 1)/Runt")|interpro:IPR013711(Runx inhibition)|interpro:IPR027384|reactome:R-MMU-8878166|reactome:R-MMU-8939902|reactome:R-MMU-8940973|reactome:R-MMU-8941326|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001501"(skeletal system development)|go:"GO:0001503"(ossification)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001958"(endochondral ossification)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002063"(chondrocyte development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030509"(BMP signaling pathway) mint:P25976|go:"GO:0001164"(RNA polymerase I core promoter sequence-specific DNA binding)|go:"GO:0001165"(RNA polymerase I cis-regulatory region sequence-specific DNA binding)|go:"GO:0001181"(RNA polymerase I general transcription initiation factor activity)|go:"GO:0001650"(fibrillar center)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0006360"(transcription by RNA polymerase I)|go:"GO:0006361"(transcription initiation from RNA polymerase I promoter)|go:"GO:0006362"(transcription elongation from RNA polymerase I promoter)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR029215|interpro:IPR036910|rcsb pdb:1V63|rcsb pdb:1V64|rcsb pdb:1WGF|reactome:R-MMU-73728|reactome:R-MMU-73762|reactome:R-MMU-73772|reactome:R-MMU-73863|dip:DIP-29977N psi-mi:"MI:0465"(dip) - comment:mint|function:UBF recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I through cooperative interactions with the species-specific factor SL1. It binds specifically to the upstream control element full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse)|taxid:10090(Mus musculus) - 2017/08/05 2017/08/10 rogid:WYs7JxHzJasUS7fx5/LzgKJEjEY10090 rogid:TJRBUUHHZDYhIRdbtsijzuOSbAo10090 rigid:TeCci/VxbIgMKbiviy8KuO/lwW8 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q08775 uniprotkb:P97357 intact:EBI-903354|uniprotkb:O35183|uniprotkb:Q08776|uniprotkb:Q9JLN0|uniprotkb:Q9QUQ6|uniprotkb:Q9QY29|uniprotkb:Q9R0U4|uniprotkb:Q9Z2J7 intact:EBI-15620048|ensembl:ENSMUSP00000142213 psi-mi:runx2_mouse(display_long)|uniprotkb:Runx2(gene name)|psi-mi:Runx2(display_short)|uniprotkb:Aml3(gene name synonym)|uniprotkb:Cbfa1(gene name synonym)|uniprotkb:Osf2(gene name synonym)|uniprotkb:Pebp2a(gene name synonym)|uniprotkb:Core-binding factor subunit alpha-1(gene name synonym)|uniprotkb:Acute myeloid leukemia 3 protein(gene name synonym)|uniprotkb:Oncogene AML-3(gene name synonym)|uniprotkb:Polyomavirus enhancer-binding protein 2 alpha A subunit(gene name synonym)|uniprotkb:SL3-3 enhancer factor 1 alpha A subunit(gene name synonym)|uniprotkb:SL3/AKV core-binding factor alpha A subunit(gene name synonym)|uniprotkb:Osteoblast-specific transcription factor 2(gene name synonym) psi-mi:taf1a_mouse(display_long)|uniprotkb:Taf1a(gene name)|psi-mi:Taf1a(display_short)|uniprotkb:RNA polymerase I-specific TBP-associated factor 48 kDa(gene name synonym)|uniprotkb:TATA box-binding protein-associated factor 1A(gene name synonym)|uniprotkb:Transcription initiation factor SL1/TIF-IB subunit A(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Young et al. (2007) pubmed:17251981|doi:10.1038/nature05473|imex:IM-21191 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15620109|imex:IM-21191-5|dip:DIP-191087E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001139510.1|refseq:NP_033950.2|refseq:NP_001258556.1|refseq:XP_006523607.1|refseq:XP_006523608.1|mint:Q08775|dip:DIP-36316N|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0040036"(regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042487"(regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048469"(cell maturation)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0140296"(general transcription initiation factor binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000040("Acute myeloid leukemia 1 protein (AML 1)/Runt")|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013524("Acute myeloid leukemia 1 (AML 1)/Runt")|interpro:IPR013711(Runx inhibition)|interpro:IPR027384|reactome:R-MMU-8878166|reactome:R-MMU-8939902|reactome:R-MMU-8940973|reactome:R-MMU-8941326|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001501"(skeletal system development)|go:"GO:0001503"(ossification)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001958"(endochondral ossification)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002063"(chondrocyte development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030509"(BMP signaling pathway) ensembl:ENSMUSG00000072258(gene)|ensembl:ENSMUST00000192076(transcript)|go:"GO:0000120"(RNA polymerase I transcription regulator complex)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006360"(transcription by RNA polymerase I)|go:"GO:0015630"(microtubule cytoskeleton)|interpro:IPR016629("RNA polymerase I, subunit A (TATA-binding protein-associated factor)")|interpro:IPR039495|reactome:R-MMU-5250924|reactome:R-MMU-73762|reactome:R-MMU-73772|reactome:R-MMU-73863|refseq:NP_001264886.1|refseq:NP_001264887.1|refseq:NP_001264888.1|refseq:NP_067441.1|dip:DIP-60267N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse)|taxid:10090(Mus musculus) - 2017/08/05 2017/08/10 rogid:WYs7JxHzJasUS7fx5/LzgKJEjEY10090 rogid:Et2wsxzqVgyRXLm4aZh5af/blMY10090 rigid:TeCci/VxbIgMKbiviy8KuO/lwW8 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9Z2J9 uniprotkb:P25977 intact:EBI-6119952|uniprotkb:Q99NC7 intact:EBI-15620127|ensembl:ENSRNOP00000063740|uniprotkb:P25978 psi-mi:runx2_rat(display_long)|uniprotkb:Runx2(gene name)|psi-mi:Runx2(display_short)|uniprotkb:Cbfa1(gene name synonym)|uniprotkb:Osf2(gene name synonym)|uniprotkb:Core-binding factor subunit alpha-1(gene name synonym)|uniprotkb:Osteoblast-specific transcription factor 2(gene name synonym) psi-mi:ubf1_rat(display_long)|uniprotkb:Ubtf(gene name)|psi-mi:Ubtf(display_short)|uniprotkb:Tcfubf(gene name synonym)|uniprotkb:Ubf-1(gene name synonym)|uniprotkb:Upstream-binding factor 1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Young et al. (2007) pubmed:17251981|doi:10.1038/nature05473|imex:IM-21191 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15620164|imex:IM-21191-6|dip:DIP-191089E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:2282|dip:DIP-60266N|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001501"(skeletal system development)|go:"GO:0001503"(ossification)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001958"(endochondral ossification)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002063"(chondrocyte development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0040036"(regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042487"(regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048469"(cell maturation)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0140296"(general transcription initiation factor binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000040("Acute myeloid leukemia 1 protein (AML 1)/Runt")|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013524("Acute myeloid leukemia 1 (AML 1)/Runt") ensembl:ENSRNOG00000020937(gene)|ensembl:ENSRNOT00000064283(transcript)|go:"GO:0001164"(RNA polymerase I core promoter sequence-specific DNA binding)|go:"GO:0001165"(RNA polymerase I cis-regulatory region sequence-specific DNA binding)|go:"GO:0001181"(RNA polymerase I general transcription initiation factor activity)|go:"GO:0001650"(fibrillar center)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0006360"(transcription by RNA polymerase I)|go:"GO:0006361"(transcription initiation from RNA polymerase I promoter)|go:"GO:0006362"(transcription elongation from RNA polymerase I promoter)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR029215|interpro:IPR036910|reactome:R-RNO-73728|reactome:R-RNO-73762|reactome:R-RNO-73772|reactome:R-RNO-73863|refseq:NP_001099193.2|refseq:NP_001121162.1|refseq:XP_006247324.1|refseq:XP_006247325.1|refseq:XP_006247326.1|refseq:XP_008766174.1|rgd:3927|dip:DIP-60265N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") - 2017/08/05 2017/08/10 rogid:WiQMKivXqKLl3yjKpGESq97pnzQ10116 rogid:NIk5I8FImM632Qy0qrDbSoZVMcI10116 rigid:x3+lNC1oFNRtOi321sJnfCI2rrg false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q13950 uniprotkb:P17480 intact:EBI-976402|intact:EBI-28971669|ensembl:ENSP00000360493|ensembl:ENSP00000495497|uniprotkb:O14614|uniprotkb:O14615|uniprotkb:O95181 intact:EBI-396235|uniprotkb:A8K6R8|ensembl:ENSP00000302640|ensembl:ENSP00000390669|ensembl:ENSP00000435708 psi-mi:runx2_human(display_long)|uniprotkb:Oncogene AML-3(gene name synonym)|uniprotkb:Polyomavirus enhancer-binding protein 2 alpha A subunit(gene name synonym)|uniprotkb:SL3-3 enhancer factor 1 alpha A subunit(gene name synonym)|uniprotkb:SL3/AKV core-binding factor alpha A subunit(gene name synonym)|uniprotkb:Osteoblast-specific transcription factor 2(gene name synonym)|uniprotkb:Core-binding factor subunit alpha-1(gene name synonym)|uniprotkb:Acute myeloid leukemia 3 protein(gene name synonym)|uniprotkb:RUNX2(gene name)|psi-mi:RUNX2(display_short)|uniprotkb:AML3(gene name synonym)|uniprotkb:CBFA1(gene name synonym)|uniprotkb:OSF2(gene name synonym)|uniprotkb:PEBP2A(gene name synonym) psi-mi:ubf1_human(display_long)|uniprotkb:UBTF(gene name)|psi-mi:UBTF(display_short)|uniprotkb:UBF(gene name synonym)|uniprotkb:UBF1(gene name synonym)|uniprotkb:Upstream-binding factor 1(gene name synonym)|uniprotkb:Autoantigen NOR-90(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Young et al. (2007) pubmed:17251981|doi:10.1038/nature05473|imex:IM-21191 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15620181|imex:IM-21191-7|dip:DIP-189063E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000359524|ensembl:ENSP00000352514|ensembl:ENST00000371432|ensembl:ENSP00000360486|ensembl:ENST00000371436|ensembl:ENSP00000360491|ensembl:ENSP00000360493|ensembl:ENSP00000495497|ensembl:ENSG00000124813(gene)|ensembl:ENST00000371438(transcript)|ensembl:ENST00000647337(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001503"(ossification)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001958"(endochondral ossification)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002063"(chondrocyte development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048469"(cell maturation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000040("Acute myeloid leukemia 1 protein (AML 1)/Runt")|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013524("Acute myeloid leukemia 1 (AML 1)/Runt")|interpro:IPR013711(Runx inhibition)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0035115"(embryonic forelimb morphogenesis)|interpro:IPR016554(Transcription factor, Runt-related, RUNX)|go:"GO:0040036"(regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|interpro:IPR027384|mint:Q13950|go:"GO:0042487"(regulation of odontogenesis of dentin-containing tooth)|go:"GO:0043425"(bHLH transcription factor binding)|rcsb pdb:6VG8|rcsb pdb:6VGD|rcsb pdb:6VGE|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|rcsb pdb:6VGG|reactome:R-HSA-2032785|reactome:R-HSA-8878166|reactome:R-HSA-8939246|reactome:R-HSA-8939902|reactome:R-HSA-8940973|reactome:R-HSA-8941284|reactome:R-HSA-8941326|reactome:R-HSA-8941332|reactome:R-HSA-8941333|refseq:NP_001015051.3|refseq:NP_001019801.3|dip:DIP-36707N refseq:NP_001070151.1|refseq:NP_001070152.1|refseq:NP_055048.1|refseq:XP_006722122.1|refseq:XP_006722123.1|refseq:XP_006722124.1|refseq:XP_016880492.1|refseq:XP_016880493.1|dip:DIP-640N|ensembl:ENSG00000108312(gene)|ensembl:ENST00000302904(transcript)|ensembl:ENST00000436088(transcript)|ensembl:ENST00000529383(transcript)|go:"GO:0001164"(RNA polymerase I core promoter sequence-specific DNA binding)|go:"GO:0001165"(RNA polymerase I cis-regulatory region sequence-specific DNA binding)|go:"GO:0001181"(RNA polymerase I general transcription initiation factor activity)|go:"GO:0001650"(fibrillar center)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006360"(transcription by RNA polymerase I)|go:"GO:0006361"(transcription initiation from RNA polymerase I promoter)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0097110"(scaffold protein binding)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR029215|interpro:IPR036910|mint:P17480|rcsb pdb:1K99|rcsb pdb:1L8Y|rcsb pdb:1L8Z|rcsb pdb:2HDZ|reactome:R-HSA-427413|reactome:R-HSA-73728|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73863 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/05 2017/08/10 rogid:aUhn8jpJsl5oS4kMBgUYdpncy6Y9606 rogid:uHwgY0OFREKv8MdMOMpREDgUEI89606 rigid:ivB4vGT9oYW321fd6YE7fygEooQ false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9Z2J9 uniprotkb:P25977 intact:EBI-6119952|uniprotkb:Q99NC7 intact:EBI-15620127|ensembl:ENSRNOP00000063740|uniprotkb:P25978 psi-mi:runx2_rat(display_long)|uniprotkb:Runx2(gene name)|psi-mi:Runx2(display_short)|uniprotkb:Cbfa1(gene name synonym)|uniprotkb:Osf2(gene name synonym)|uniprotkb:Core-binding factor subunit alpha-1(gene name synonym)|uniprotkb:Osteoblast-specific transcription factor 2(gene name synonym) psi-mi:ubf1_rat(display_long)|uniprotkb:Ubtf(gene name)|psi-mi:Ubtf(display_short)|uniprotkb:Tcfubf(gene name synonym)|uniprotkb:Ubf-1(gene name synonym)|uniprotkb:Upstream-binding factor 1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Young et al. (2007) pubmed:17251981|doi:10.1038/nature05473|imex:IM-21191 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15620198|imex:IM-21191-8|dip:DIP-191089E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:2282|dip:DIP-60266N|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001501"(skeletal system development)|go:"GO:0001503"(ossification)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001958"(endochondral ossification)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002063"(chondrocyte development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0040036"(regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042487"(regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048469"(cell maturation)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0140296"(general transcription initiation factor binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000040("Acute myeloid leukemia 1 protein (AML 1)/Runt")|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013524("Acute myeloid leukemia 1 (AML 1)/Runt") ensembl:ENSRNOG00000020937(gene)|ensembl:ENSRNOT00000064283(transcript)|go:"GO:0001164"(RNA polymerase I core promoter sequence-specific DNA binding)|go:"GO:0001165"(RNA polymerase I cis-regulatory region sequence-specific DNA binding)|go:"GO:0001181"(RNA polymerase I general transcription initiation factor activity)|go:"GO:0001650"(fibrillar center)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0006360"(transcription by RNA polymerase I)|go:"GO:0006361"(transcription initiation from RNA polymerase I promoter)|go:"GO:0006362"(transcription elongation from RNA polymerase I promoter)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR029215|interpro:IPR036910|reactome:R-RNO-73728|reactome:R-RNO-73762|reactome:R-RNO-73772|reactome:R-RNO-73863|refseq:NP_001099193.2|refseq:NP_001121162.1|refseq:XP_006247324.1|refseq:XP_006247325.1|refseq:XP_006247326.1|refseq:XP_008766174.1|rgd:3927|dip:DIP-60265N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") - 2017/08/05 2017/08/10 rogid:WiQMKivXqKLl3yjKpGESq97pnzQ10116 rogid:NIk5I8FImM632Qy0qrDbSoZVMcI10116 rigid:x3+lNC1oFNRtOi321sJnfCI2rrg false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)