#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P44868 uniprotkb:P44868 intact:EBI-15618808|ensemblbacteria:AAC22424 intact:EBI-15618808|ensemblbacteria:AAC22424 psi-mi:trml_haein(display_long)|uniprotkb:trmL(gene name)|psi-mi:trmL(display_short)|uniprotkb:"tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmL"(gene name synonym)|uniprotkb:HI_0766(locus name) psi-mi:trml_haein(display_long)|uniprotkb:trmL(gene name)|psi-mi:trmL(display_short)|uniprotkb:"tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmL"(gene name synonym)|uniprotkb:HI_0766(locus name) psi-mi:"MI:0071"(molecular sieving) Mallam et al. (2007) pubmed:17223537|doi:10.1016/j.str.2006.11.007|imex:IM-8492 taxid:71421(haein)|taxid:71421(Haemophilus influenzae) taxid:71421(haein)|taxid:71421(Haemophilus influenzae) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15618828|imex:IM-8492-1|dip:DIP-57180E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblbacteria:AAC22424(transcript)|ensemblbacteria:HI_0766(gene)|go:"GO:0002131"(wobble position cytosine ribose methylation)|go:"GO:0002132"(wobble position uridine ribose methylation)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0008175"(tRNA methyltransferase activity)|go:"GO:0008757"(S-adenosylmethionine-dependent methyltransferase activity)|go:"GO:0042802"(identical protein binding)|interpro:IPR001537(tRNA/rRNA methyltransferase, SpoU)|interpro:IPR016914(S-adenosyl-L-methionine dependent tRNA/rRNA methyltransferase, SpoU, predicted)|interpro:IPR029026|interpro:IPR029028|rcsb pdb:1J85|rcsb pdb:1MXI|rcsb pdb:6AHW|refseq:NP_438925.1|refseq:WP_005652354.1|dip:DIP-29173N ensemblbacteria:AAC22424(transcript)|ensemblbacteria:HI_0766(gene)|go:"GO:0002131"(wobble position cytosine ribose methylation)|go:"GO:0002132"(wobble position uridine ribose methylation)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0008175"(tRNA methyltransferase activity)|go:"GO:0008757"(S-adenosylmethionine-dependent methyltransferase activity)|go:"GO:0042802"(identical protein binding)|interpro:IPR001537(tRNA/rRNA methyltransferase, SpoU)|interpro:IPR016914(S-adenosyl-L-methionine dependent tRNA/rRNA methyltransferase, SpoU, predicted)|interpro:IPR029026|interpro:IPR029028|rcsb pdb:1J85|rcsb pdb:1MXI|rcsb pdb:6AHW|refseq:NP_438925.1|refseq:WP_005652354.1|dip:DIP-29173N psi-mi:"MI:0465"(dip) crc64:0E09ADB31E575026 crc64:0E09ADB31E575026 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:562(ecolx)|taxid:562(Escherichia coli) - 2017/08/05 2017/08/10 rogid:Teu7hwTnRhhmzpYMt4nITzkksZQ71421 rogid:Teu7hwTnRhhmzpYMt4nITzkksZQ71421 rigid:SytB41hkX6q8zP2prhm0ivkVrs4 false mutation disrupting interaction:143-143|mutation disrupting interaction:139-139|mutation disrupting interaction:87-87,24-24,20-20,143-143,142-142,139-139 mutation disrupting interaction:143-143|mutation disrupting interaction:139-139|mutation disrupting interaction:87-87,24-24,20-20,143-143,142-142,139-139 - 0 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P44868 uniprotkb:P44868 intact:EBI-15618808|ensemblbacteria:AAC22424 intact:EBI-15618808|ensemblbacteria:AAC22424 psi-mi:trml_haein(display_long)|uniprotkb:trmL(gene name)|psi-mi:trmL(display_short)|uniprotkb:"tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmL"(gene name synonym)|uniprotkb:HI_0766(locus name) psi-mi:trml_haein(display_long)|uniprotkb:trmL(gene name)|psi-mi:trmL(display_short)|uniprotkb:"tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmL"(gene name synonym)|uniprotkb:HI_0766(locus name) psi-mi:"MI:0016"(circular dichroism) Mallam et al. (2007) pubmed:17223537|doi:10.1016/j.str.2006.11.007|imex:IM-8492 taxid:71421(haein)|taxid:71421(Haemophilus influenzae) taxid:71421(haein)|taxid:71421(Haemophilus influenzae) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15618858|imex:IM-8492-2|dip:DIP-57180E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblbacteria:AAC22424(transcript)|ensemblbacteria:HI_0766(gene)|go:"GO:0002131"(wobble position cytosine ribose methylation)|go:"GO:0002132"(wobble position uridine ribose methylation)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0008175"(tRNA methyltransferase activity)|go:"GO:0008757"(S-adenosylmethionine-dependent methyltransferase activity)|go:"GO:0042802"(identical protein binding)|interpro:IPR001537(tRNA/rRNA methyltransferase, SpoU)|interpro:IPR016914(S-adenosyl-L-methionine dependent tRNA/rRNA methyltransferase, SpoU, predicted)|interpro:IPR029026|interpro:IPR029028|rcsb pdb:1J85|rcsb pdb:1MXI|rcsb pdb:6AHW|refseq:NP_438925.1|refseq:WP_005652354.1|dip:DIP-29173N ensemblbacteria:AAC22424(transcript)|ensemblbacteria:HI_0766(gene)|go:"GO:0002131"(wobble position cytosine ribose methylation)|go:"GO:0002132"(wobble position uridine ribose methylation)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0008175"(tRNA methyltransferase activity)|go:"GO:0008757"(S-adenosylmethionine-dependent methyltransferase activity)|go:"GO:0042802"(identical protein binding)|interpro:IPR001537(tRNA/rRNA methyltransferase, SpoU)|interpro:IPR016914(S-adenosyl-L-methionine dependent tRNA/rRNA methyltransferase, SpoU, predicted)|interpro:IPR029026|interpro:IPR029028|rcsb pdb:1J85|rcsb pdb:1MXI|rcsb pdb:6AHW|refseq:NP_438925.1|refseq:WP_005652354.1|dip:DIP-29173N psi-mi:"MI:0465"(dip) crc64:0E09ADB31E575026 crc64:0E09ADB31E575026 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:562(ecolx)|taxid:562(Escherichia coli) - 2017/08/05 2017/08/10 rogid:Teu7hwTnRhhmzpYMt4nITzkksZQ71421 rogid:Teu7hwTnRhhmzpYMt4nITzkksZQ71421 rigid:SytB41hkX6q8zP2prhm0ivkVrs4 false mutation decreasing interaction:139-139|mutation disrupting interaction:87-87,24-24,20-20,143-143,142-142,139-139|mutation decreasing interaction:87-87,24-24,20-20,143-143,142-142 mutation decreasing interaction:139-139|mutation disrupting interaction:87-87,24-24,20-20,143-143,142-142,139-139|mutation decreasing interaction:87-87,24-24,20-20,143-143,142-142 - 0 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)