#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:O54918-3 uniprotkb:Q07817-1 intact:EBI-526084|ensembl:ENSMUSP00000019281|ensembl:ENSMUSP00000099500|intact:EBI-7424890|intact:MINT-89475 intact:EBI-287195|ensembl:ENSP00000302564|ensembl:ENSP00000365230|ensembl:ENSP00000389688|ensembl:ENSP00000390760|ensembl:ENSP00000395545|ensembl:ENSP00000401173|ensembl:ENSP00000503725|ensembl:ENSP00000504237|ensembl:ENSP00000504387|ensembl:ENSP00000504536|intact:EBI-8058735|intact:MINT-89566|intact:EBI-8058554|intact:EBI-8058512|intact:EBI-8058443 psi-mi:o54918-3(display_long)|uniprotkb:Bcl2l11(gene name)|psi-mi:Bcl2l11(display_short)|uniprotkb:Bim(gene name synonym)|uniprotkb:Bcl2-interacting mediator of cell death(gene name synonym) psi-mi:q07817-1(display_long)|uniprotkb:BCLX(gene name synonym)|uniprotkb:Apoptosis regulator Bcl-X(gene name synonym)|uniprotkb:BCL2L1(gene name)|psi-mi:BCL2L1(display_short)|uniprotkb:BCL2L(gene name synonym)|uniprotkb:Bcl-xL(isoform synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Zhao et al. (2007) pubmed:17177603|doi:10.1371/journal.pbio.0050001|imex:IM-8547 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15616455|imex:IM-8547-4|dip:DIP-57230E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-526067(bim_mouse)|ensembl:ENSMUST00000019281(transcript)|ensembl:ENSMUST00000103211(transcript)|ensembl:ENSMUSG00000027381(gene) intact:EBI-78035(bclx_human)|ensembl:ENSG00000171552(gene)|ensembl:ENST00000678563(transcript)|ensembl:ENST00000307677(transcript)|ensembl:ENST00000376062(transcript)|ensembl:ENST00000420488(transcript)|ensembl:ENST00000434194(transcript)|ensembl:ENST00000439267(transcript)|ensembl:ENST00000456404(transcript)|ensembl:ENST00000676582(transcript)|ensembl:ENST00000676942(transcript)|ensembl:ENST00000677194(transcript) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse)|taxid:10090(Mus musculus) - 2017/08/05 2017/08/10 rogid:bIpR7awYTDm87yTgIVeDKrUeA6E10090 rogid:lDDsMUf2W6uLKpfM3h4N364tpWg9606 rigid:3gJu9iqzdUezK8NsiJmIr9+OkIE false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q07817-1 uniprotkb:Q9BXH1 intact:EBI-287195|ensembl:ENSP00000302564|ensembl:ENSP00000365230|ensembl:ENSP00000389688|ensembl:ENSP00000390760|ensembl:ENSP00000395545|ensembl:ENSP00000401173|ensembl:ENSP00000503725|ensembl:ENSP00000504237|ensembl:ENSP00000504387|ensembl:ENSP00000504536|intact:EBI-8058735|intact:MINT-89566|intact:EBI-8058554|intact:EBI-8058512|intact:EBI-8058443 intact:EBI-519884|uniprotkb:O00171|uniprotkb:Q96PG9|ensembl:ENSP00000395862|uniprotkb:B9EGI3 psi-mi:q07817-1(display_long)|uniprotkb:BCLX(gene name synonym)|uniprotkb:Apoptosis regulator Bcl-X(gene name synonym)|uniprotkb:BCL2L1(gene name)|psi-mi:BCL2L1(display_short)|uniprotkb:BCL2L(gene name synonym)|uniprotkb:Bcl-xL(isoform synonym) psi-mi:bbc3_human(display_long)|uniprotkb:p53 up-regulated modulator of apoptosis(gene name synonym)|uniprotkb:JFY-1(gene name synonym)|uniprotkb:BBC3(gene name)|psi-mi:BBC3(display_short)|uniprotkb:PUMA(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Zhao et al. (2007) pubmed:17177603|doi:10.1371/journal.pbio.0050001|imex:IM-8547 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15616472|imex:IM-8547-3|dip:DIP-57231E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-78035(bclx_human)|ensembl:ENSG00000171552(gene)|ensembl:ENST00000678563(transcript)|ensembl:ENST00000307677(transcript)|ensembl:ENST00000376062(transcript)|ensembl:ENST00000420488(transcript)|ensembl:ENST00000434194(transcript)|ensembl:ENST00000439267(transcript)|ensembl:ENST00000456404(transcript)|ensembl:ENST00000676582(transcript)|ensembl:ENST00000676942(transcript)|ensembl:ENST00000677194(transcript) refseq:NP_001120713.1|refseq:NP_055232.1|refseq:XP_006723204.1|ensembl:ENSG00000105327(gene)|ensembl:ENST00000439096(transcript)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032464"(positive regulation of protein homooligomerization)|go:"GO:0032471"(negative regulation of endoplasmic reticulum calcium ion concentration)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045926"(negative regulation of growth)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1900740"(positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway)|go:"GO:1901998"(toxin transport)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903896"(positive regulation of IRE1-mediated unfolded protein response)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR031661|mint:Q9BXH1|rcsb pdb:2M04|rcsb pdb:4BPI|rcsb pdb:4BPJ|rcsb pdb:4BPK|rcsb pdb:4HNJ|rcsb pdb:5UUL|rcsb pdb:6QFM|rcsb pdb:6QG8|rcsb pdb:6TQP|reactome:R-HSA-111453|reactome:R-HSA-139915|reactome:R-HSA-6803204|reactome:R-HSA-9614657|refseq:NP_001120712.1|refseq:NP_001120714.1|dip:DIP-29215N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse)|taxid:10090(Mus musculus) - 2017/08/05 2017/08/10 rogid:lDDsMUf2W6uLKpfM3h4N364tpWg9606 rogid:rWcs573MgFjZoNgLuPltNrK/8pU9606 rigid:OiLV2N4+/KqZ20LjyTYYMDsOrec false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q07817-1 uniprotkb:O54918-3 intact:EBI-287195|ensembl:ENSP00000302564|ensembl:ENSP00000365230|ensembl:ENSP00000389688|ensembl:ENSP00000390760|ensembl:ENSP00000395545|ensembl:ENSP00000401173|ensembl:ENSP00000503725|ensembl:ENSP00000504237|ensembl:ENSP00000504387|ensembl:ENSP00000504536|intact:EBI-8058735|intact:MINT-89566|intact:EBI-8058554|intact:EBI-8058512|intact:EBI-8058443 intact:EBI-526084|ensembl:ENSMUSP00000019281|ensembl:ENSMUSP00000099500|intact:EBI-7424890|intact:MINT-89475 psi-mi:q07817-1(display_long)|uniprotkb:BCLX(gene name synonym)|uniprotkb:Apoptosis regulator Bcl-X(gene name synonym)|uniprotkb:BCL2L1(gene name)|psi-mi:BCL2L1(display_short)|uniprotkb:BCL2L(gene name synonym)|uniprotkb:Bcl-xL(isoform synonym) psi-mi:o54918-3(display_long)|uniprotkb:Bcl2l11(gene name)|psi-mi:Bcl2l11(display_short)|uniprotkb:Bim(gene name synonym)|uniprotkb:Bcl2-interacting mediator of cell death(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Zhao et al. (2007) pubmed:17177603|doi:10.1371/journal.pbio.0050001|imex:IM-8547 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15616472|imex:IM-8547-3|dip:DIP-57231E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-78035(bclx_human)|ensembl:ENSG00000171552(gene)|ensembl:ENST00000678563(transcript)|ensembl:ENST00000307677(transcript)|ensembl:ENST00000376062(transcript)|ensembl:ENST00000420488(transcript)|ensembl:ENST00000434194(transcript)|ensembl:ENST00000439267(transcript)|ensembl:ENST00000456404(transcript)|ensembl:ENST00000676582(transcript)|ensembl:ENST00000676942(transcript)|ensembl:ENST00000677194(transcript) intact:EBI-526067(bim_mouse)|ensembl:ENSMUST00000019281(transcript)|ensembl:ENSMUST00000103211(transcript)|ensembl:ENSMUSG00000027381(gene) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse)|taxid:10090(Mus musculus) - 2017/08/05 2017/08/10 rogid:lDDsMUf2W6uLKpfM3h4N364tpWg9606 rogid:bIpR7awYTDm87yTgIVeDKrUeA6E10090 rigid:OiLV2N4+/KqZ20LjyTYYMDsOrec false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:O54918-3 uniprotkb:Q07817-1 intact:EBI-526084|ensembl:ENSMUSP00000019281|ensembl:ENSMUSP00000099500|intact:EBI-7424890|intact:MINT-89475 intact:EBI-287195|ensembl:ENSP00000302564|ensembl:ENSP00000365230|ensembl:ENSP00000389688|ensembl:ENSP00000390760|ensembl:ENSP00000395545|ensembl:ENSP00000401173|ensembl:ENSP00000503725|ensembl:ENSP00000504237|ensembl:ENSP00000504387|ensembl:ENSP00000504536|intact:EBI-8058735|intact:MINT-89566|intact:EBI-8058554|intact:EBI-8058512|intact:EBI-8058443 psi-mi:o54918-3(display_long)|uniprotkb:Bcl2l11(gene name)|psi-mi:Bcl2l11(display_short)|uniprotkb:Bim(gene name synonym)|uniprotkb:Bcl2-interacting mediator of cell death(gene name synonym) psi-mi:q07817-1(display_long)|uniprotkb:BCLX(gene name synonym)|uniprotkb:Apoptosis regulator Bcl-X(gene name synonym)|uniprotkb:BCL2L1(gene name)|psi-mi:BCL2L1(display_short)|uniprotkb:BCL2L(gene name synonym)|uniprotkb:Bcl-xL(isoform synonym) psi-mi:"MI:0004"(affinity chromatography technology) Zhao et al. (2007) pubmed:17177603|doi:10.1371/journal.pbio.0050001|imex:IM-8547 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15616490|imex:IM-8547-2|dip:DIP-57230E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-526067(bim_mouse)|ensembl:ENSMUST00000019281(transcript)|ensembl:ENSMUST00000103211(transcript)|ensembl:ENSMUSG00000027381(gene) intact:EBI-78035(bclx_human)|ensembl:ENSG00000171552(gene)|ensembl:ENST00000678563(transcript)|ensembl:ENST00000307677(transcript)|ensembl:ENST00000376062(transcript)|ensembl:ENST00000420488(transcript)|ensembl:ENST00000434194(transcript)|ensembl:ENST00000439267(transcript)|ensembl:ENST00000456404(transcript)|ensembl:ENST00000676582(transcript)|ensembl:ENST00000676942(transcript)|ensembl:ENST00000677194(transcript) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:bIpR7awYTDm87yTgIVeDKrUeA6E10090 rogid:lDDsMUf2W6uLKpfM3h4N364tpWg9606 rigid:3gJu9iqzdUezK8NsiJmIr9+OkIE false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BXH1 uniprotkb:Q07817-1 intact:EBI-519884|uniprotkb:O00171|uniprotkb:Q96PG9|ensembl:ENSP00000395862|uniprotkb:B9EGI3 intact:EBI-287195|ensembl:ENSP00000302564|ensembl:ENSP00000365230|ensembl:ENSP00000389688|ensembl:ENSP00000390760|ensembl:ENSP00000395545|ensembl:ENSP00000401173|ensembl:ENSP00000503725|ensembl:ENSP00000504237|ensembl:ENSP00000504387|ensembl:ENSP00000504536|intact:EBI-8058735|intact:MINT-89566|intact:EBI-8058554|intact:EBI-8058512|intact:EBI-8058443 psi-mi:bbc3_human(display_long)|uniprotkb:p53 up-regulated modulator of apoptosis(gene name synonym)|uniprotkb:JFY-1(gene name synonym)|uniprotkb:BBC3(gene name)|psi-mi:BBC3(display_short)|uniprotkb:PUMA(gene name synonym) psi-mi:q07817-1(display_long)|uniprotkb:BCLX(gene name synonym)|uniprotkb:Apoptosis regulator Bcl-X(gene name synonym)|uniprotkb:BCL2L1(gene name)|psi-mi:BCL2L1(display_short)|uniprotkb:BCL2L(gene name synonym)|uniprotkb:Bcl-xL(isoform synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Zhao et al. (2007) pubmed:17177603|doi:10.1371/journal.pbio.0050001|imex:IM-8547 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15616507|imex:IM-8547-1|dip:DIP-57232E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001120713.1|refseq:NP_055232.1|refseq:XP_006723204.1|ensembl:ENSG00000105327(gene)|ensembl:ENST00000439096(transcript)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032464"(positive regulation of protein homooligomerization)|go:"GO:0032471"(negative regulation of endoplasmic reticulum calcium ion concentration)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045926"(negative regulation of growth)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1900740"(positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway)|go:"GO:1901998"(toxin transport)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903896"(positive regulation of IRE1-mediated unfolded protein response)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR031661|mint:Q9BXH1|rcsb pdb:2M04|rcsb pdb:4BPI|rcsb pdb:4BPJ|rcsb pdb:4BPK|rcsb pdb:4HNJ|rcsb pdb:5UUL|rcsb pdb:6QFM|rcsb pdb:6QG8|rcsb pdb:6TQP|reactome:R-HSA-111453|reactome:R-HSA-139915|reactome:R-HSA-6803204|reactome:R-HSA-9614657|refseq:NP_001120712.1|refseq:NP_001120714.1|dip:DIP-29215N intact:EBI-78035(bclx_human)|ensembl:ENSG00000171552(gene)|ensembl:ENST00000678563(transcript)|ensembl:ENST00000307677(transcript)|ensembl:ENST00000376062(transcript)|ensembl:ENST00000420488(transcript)|ensembl:ENST00000434194(transcript)|ensembl:ENST00000439267(transcript)|ensembl:ENST00000456404(transcript)|ensembl:ENST00000676582(transcript)|ensembl:ENST00000676942(transcript)|ensembl:ENST00000677194(transcript) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse)|taxid:10090(Mus musculus) - 2017/08/05 2017/08/10 rogid:rWcs573MgFjZoNgLuPltNrK/8pU9606 rogid:lDDsMUf2W6uLKpfM3h4N364tpWg9606 rigid:IpzWIbP3V1X+l5peIK52n9LB1xc false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)