#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q62962-2 uniprotkb:D4A100 intact:EBI-15615759 intact:EBI-15615743|ensembl:ENSRNOP00000014765 psi-mi:q62962-2(display_long)|uniprotkb:Asic2(gene name)|psi-mi:Asic2(display_short)|uniprotkb:Accn1(gene name synonym)|uniprotkb:Amiloride-sensitive brain sodium channel(gene name synonym)|uniprotkb:Amiloride-sensitive brain sodium channel 2(gene name synonym)|uniprotkb:Amiloride-sensitive cation channel 1, neuronal(gene name synonym)|uniprotkb:Amiloride-sensitive cation channel neuronal 1(gene name synonym)|uniprotkb:Bnac1(gene name synonym)|uniprotkb:Brain sodium channel 1(gene name synonym)|uniprotkb:Mammalian degenerin homolog(gene name synonym)|uniprotkb:Mdeg(gene name synonym)|uniprotkb:Asic2b(isoform synonym)|uniprotkb:Mdeg2(isoform synonym) psi-mi:d4a100_rat(display_long)|uniprotkb:Stoml3(gene name)|psi-mi:Stoml3(display_short)|uniprotkb:Stoml3_predicted(gene name synonym)|uniprotkb:rCG_49955(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wetzel et al. (2007) pubmed:17167420|doi:10.1038/nature05394|imex:IM-21186 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15615775|imex:IM-21186-1|dip:DIP-191081E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-8056477(isoform-parent) ensembl:ENSRNOG00000011006(gene)|ensembl:ENSRNOT00000014765(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007165"(signal transduction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0045121"(membrane raft)|interpro:IPR028519|interpro:IPR043202|refseq:NP_001099901.1|rgd:1311090|dip:DIP-60262N psi-mi:"MI:0465"(dip) isoform-comment:Seems to be inactive as monomer or in a monomeric assembly and is not activated by mutagenesis of Gly-430. Mutagenesis of Ser-60 into Gly reduces activation by PKC through PRKCABP/PICK-1 of a ASIC3/ACCN3-ASIC2/ASIC2b channel. - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/05 2017/08/10 rogid:xZsV2D8aObAXKSDM/V+EkqRuOkU10116 rogid:uyWEHELYhNG4m+FXVGbxoNGbvs810116 rigid:+6x3pKjSZpmK0/FgztpmtVXW5EM false flag tag:?-? myc tag:c-c - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:O35240 uniprotkb:D4A100 intact:EBI-982374|ensembl:ENSRNOP00000011300 intact:EBI-15615743|ensembl:ENSRNOP00000014765 psi-mi:asic3_rat(display_long)|uniprotkb:Asic3(gene name)|psi-mi:Asic3(display_short)|uniprotkb:Accn3(gene name synonym)|uniprotkb:Amiloride-sensitive cation channel 3(gene name synonym)|uniprotkb:Dorsal root ASIC(gene name synonym)|uniprotkb:Drasic(gene name synonym) psi-mi:d4a100_rat(display_long)|uniprotkb:Stoml3(gene name)|psi-mi:Stoml3(display_short)|uniprotkb:Stoml3_predicted(gene name synonym)|uniprotkb:rCG_49955(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wetzel et al. (2007) pubmed:17167420|doi:10.1038/nature05394|imex:IM-21186 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15615837|imex:IM-21186-3|dip:DIP-191082E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSRNOG00000008380(gene)|ensembl:ENSRNOT00000011300(transcript)|go:"GO:0005261"(cation channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006814"(sodium ion transport)|go:"GO:0009408"(response to heat)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010447"(response to acidic pH)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042931"(enterobactin transmembrane transporter activity)|go:"GO:0044736"(acid-sensing ion channel activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050907"(detection of chemical stimulus involved in sensory perception)|go:"GO:0050915"(sensory perception of sour taste)|go:"GO:0050961"(detection of temperature stimulus involved in sensory perception)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050968"(detection of chemical stimulus involved in sensory perception of pain)|go:"GO:0050974"(detection of mechanical stimulus involved in sensory perception)|interpro:IPR001873(Na+ channel, amiloride-sensitive)|interpro:IPR004724(Epithelial sodium channel)|interpro:IPR020903|reactome:R-RNO-2672351|go:"GO:0015280"(ligand-gated sodium channel activity)|rgd:708578|refseq:NP_775158.1|dip:DIP-35759N ensembl:ENSRNOG00000011006(gene)|ensembl:ENSRNOT00000014765(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007165"(signal transduction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0045121"(membrane raft)|interpro:IPR028519|interpro:IPR043202|refseq:NP_001099901.1|rgd:1311090|dip:DIP-60262N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/05 2017/08/10 rogid:/i0glFSd0K7nTVETeyK4jd6cYUM10116 rogid:uyWEHELYhNG4m+FXVGbxoNGbvs810116 rigid:Q2yaPFWnqH/RiFLsJ/IkOHqU2hM false flag tag:n-n myc tag:c-c - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q62962-2 uniprotkb:D4A100 intact:EBI-15615759 intact:EBI-15615743|ensembl:ENSRNOP00000014765 psi-mi:q62962-2(display_long)|uniprotkb:Asic2(gene name)|psi-mi:Asic2(display_short)|uniprotkb:Accn1(gene name synonym)|uniprotkb:Amiloride-sensitive brain sodium channel(gene name synonym)|uniprotkb:Amiloride-sensitive brain sodium channel 2(gene name synonym)|uniprotkb:Amiloride-sensitive cation channel 1, neuronal(gene name synonym)|uniprotkb:Amiloride-sensitive cation channel neuronal 1(gene name synonym)|uniprotkb:Bnac1(gene name synonym)|uniprotkb:Brain sodium channel 1(gene name synonym)|uniprotkb:Mammalian degenerin homolog(gene name synonym)|uniprotkb:Mdeg(gene name synonym)|uniprotkb:Asic2b(isoform synonym)|uniprotkb:Mdeg2(isoform synonym) psi-mi:d4a100_rat(display_long)|uniprotkb:Stoml3(gene name)|psi-mi:Stoml3(display_short)|uniprotkb:Stoml3_predicted(gene name synonym)|uniprotkb:rCG_49955(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wetzel et al. (2007) pubmed:17167420|doi:10.1038/nature05394|imex:IM-21186 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15615858|imex:IM-21186-4|dip:DIP-191081E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-8056477(isoform-parent) ensembl:ENSRNOG00000011006(gene)|ensembl:ENSRNOT00000014765(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007165"(signal transduction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0045121"(membrane raft)|interpro:IPR028519|interpro:IPR043202|refseq:NP_001099901.1|rgd:1311090|dip:DIP-60262N psi-mi:"MI:0465"(dip) isoform-comment:Seems to be inactive as monomer or in a monomeric assembly and is not activated by mutagenesis of Gly-430. Mutagenesis of Ser-60 into Gly reduces activation by PKC through PRKCABP/PICK-1 of a ASIC3/ACCN3-ASIC2/ASIC2b channel. - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/05 2017/08/10 rogid:xZsV2D8aObAXKSDM/V+EkqRuOkU10116 rogid:uyWEHELYhNG4m+FXVGbxoNGbvs810116 rigid:+6x3pKjSZpmK0/FgztpmtVXW5EM false flag tag:?-? myc tag:c-c - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q62962-1 uniprotkb:D4A100 intact:EBI-15615798 intact:EBI-15615743|ensembl:ENSRNOP00000014765 psi-mi:q62962-1(display_long)|uniprotkb:Asic2(gene name)|psi-mi:Asic2(display_short)|uniprotkb:Accn1(gene name synonym)|uniprotkb:Bnac1(gene name synonym)|uniprotkb:Mdeg(gene name synonym)|uniprotkb:Mdeg1(isoform synonym)|uniprotkb:Asic2a(isoform synonym)|uniprotkb:Amiloride-sensitive brain sodium channel(gene name synonym)|uniprotkb:Amiloride-sensitive brain sodium channel 2(gene name synonym)|uniprotkb:Amiloride-sensitive cation channel 1, neuronal(gene name synonym)|uniprotkb:Amiloride-sensitive cation channel neuronal 1(gene name synonym)|uniprotkb:Brain sodium channel 1(gene name synonym)|uniprotkb:Mammalian degenerin homolog(gene name synonym) psi-mi:d4a100_rat(display_long)|uniprotkb:Stoml3(gene name)|psi-mi:Stoml3(display_short)|uniprotkb:Stoml3_predicted(gene name synonym)|uniprotkb:rCG_49955(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wetzel et al. (2007) pubmed:17167420|doi:10.1038/nature05394|imex:IM-21186 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15615881|imex:IM-21186-5|dip:DIP-191081E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-8056477(isoform-parent) ensembl:ENSRNOG00000011006(gene)|ensembl:ENSRNOT00000014765(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007165"(signal transduction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0045121"(membrane raft)|interpro:IPR028519|interpro:IPR043202|refseq:NP_001099901.1|rgd:1311090|dip:DIP-60262N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/05 2017/08/10 rogid:ZafUzFIbXkxMXYvzpeJBfQ+jYEI10116 rogid:uyWEHELYhNG4m+FXVGbxoNGbvs810116 rigid:pUB+ocP06Nwy8ynrclZ/JFFv210 false flag tag:?-? myc tag:c-c - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q62962-1 uniprotkb:D4A100 intact:EBI-15615798 intact:EBI-15615743|ensembl:ENSRNOP00000014765 psi-mi:q62962-1(display_long)|uniprotkb:Asic2(gene name)|psi-mi:Asic2(display_short)|uniprotkb:Accn1(gene name synonym)|uniprotkb:Bnac1(gene name synonym)|uniprotkb:Mdeg(gene name synonym)|uniprotkb:Mdeg1(isoform synonym)|uniprotkb:Asic2a(isoform synonym)|uniprotkb:Amiloride-sensitive brain sodium channel(gene name synonym)|uniprotkb:Amiloride-sensitive brain sodium channel 2(gene name synonym)|uniprotkb:Amiloride-sensitive cation channel 1, neuronal(gene name synonym)|uniprotkb:Amiloride-sensitive cation channel neuronal 1(gene name synonym)|uniprotkb:Brain sodium channel 1(gene name synonym)|uniprotkb:Mammalian degenerin homolog(gene name synonym) psi-mi:d4a100_rat(display_long)|uniprotkb:Stoml3(gene name)|psi-mi:Stoml3(display_short)|uniprotkb:Stoml3_predicted(gene name synonym)|uniprotkb:rCG_49955(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wetzel et al. (2007) pubmed:17167420|doi:10.1038/nature05394|imex:IM-21186 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15615814|imex:IM-21186-2|dip:DIP-191081E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-8056477(isoform-parent) ensembl:ENSRNOG00000011006(gene)|ensembl:ENSRNOT00000014765(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007165"(signal transduction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0045121"(membrane raft)|interpro:IPR028519|interpro:IPR043202|refseq:NP_001099901.1|rgd:1311090|dip:DIP-60262N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/05 2017/08/10 rogid:ZafUzFIbXkxMXYvzpeJBfQ+jYEI10116 rogid:uyWEHELYhNG4m+FXVGbxoNGbvs810116 rigid:pUB+ocP06Nwy8ynrclZ/JFFv210 false flag tag:?-? myc tag:c-c - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:D4A100 uniprotkb:O35240 intact:EBI-15615743|ensembl:ENSRNOP00000014765 intact:EBI-982374|ensembl:ENSRNOP00000011300 psi-mi:d4a100_rat(display_long)|uniprotkb:Stoml3(gene name)|psi-mi:Stoml3(display_short)|uniprotkb:Stoml3_predicted(gene name synonym)|uniprotkb:rCG_49955(orf name) psi-mi:asic3_rat(display_long)|uniprotkb:Asic3(gene name)|psi-mi:Asic3(display_short)|uniprotkb:Accn3(gene name synonym)|uniprotkb:Amiloride-sensitive cation channel 3(gene name synonym)|uniprotkb:Dorsal root ASIC(gene name synonym)|uniprotkb:Drasic(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wetzel et al. (2007) pubmed:17167420|doi:10.1038/nature05394|imex:IM-21186 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15615904|imex:IM-21186-6|dip:DIP-191082E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSRNOG00000011006(gene)|ensembl:ENSRNOT00000014765(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007165"(signal transduction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0045121"(membrane raft)|interpro:IPR028519|interpro:IPR043202|refseq:NP_001099901.1|rgd:1311090|dip:DIP-60262N ensembl:ENSRNOG00000008380(gene)|ensembl:ENSRNOT00000011300(transcript)|go:"GO:0005261"(cation channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006814"(sodium ion transport)|go:"GO:0009408"(response to heat)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010447"(response to acidic pH)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042931"(enterobactin transmembrane transporter activity)|go:"GO:0044736"(acid-sensing ion channel activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050907"(detection of chemical stimulus involved in sensory perception)|go:"GO:0050915"(sensory perception of sour taste)|go:"GO:0050961"(detection of temperature stimulus involved in sensory perception)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050968"(detection of chemical stimulus involved in sensory perception of pain)|go:"GO:0050974"(detection of mechanical stimulus involved in sensory perception)|interpro:IPR001873(Na+ channel, amiloride-sensitive)|interpro:IPR004724(Epithelial sodium channel)|interpro:IPR020903|reactome:R-RNO-2672351|go:"GO:0015280"(ligand-gated sodium channel activity)|rgd:708578|refseq:NP_775158.1|dip:DIP-35759N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/05 2017/08/10 rogid:uyWEHELYhNG4m+FXVGbxoNGbvs810116 rogid:/i0glFSd0K7nTVETeyK4jd6cYUM10116 rigid:Q2yaPFWnqH/RiFLsJ/IkOHqU2hM false myc tag:c-c flag tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)