#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P41813 uniprotkb:P32562 intact:EBI-6973|uniprotkb:D6W1B1|ensemblfungi:YNL068C intact:EBI-4440|ensemblfungi:YMR001C|uniprotkb:D6VZH5 psi-mi:fkh2_yeast(display_long)|uniprotkb:N2403(orf name)|uniprotkb:YNL2403C(orf name)|uniprotkb:YNL068C(locus name)|uniprotkb:FKH2(gene name)|psi-mi:FKH2(display_short) psi-mi:cdc5_yeast(display_long)|uniprotkb:CDC5(gene name)|psi-mi:CDC5(display_short)|uniprotkb:MSD2(gene name synonym)|uniprotkb:PKX2(gene name synonym)|uniprotkb:YMR001C(locus name)|uniprotkb:YM8270.03C(orf name) psi-mi:"MI:0096"(pull down) Darieva et al. (2006) pubmed:17122856|doi:10.1038/nature05339|imex:IM-21615 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15613276|imex:IM-21615-1|dip:DIP-192030E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) sgd:S000005012|refseq:NP_014331.3|dip:DIP-5944N|mint:P41813|ensemblfungi:YNL068C(gene)|ensemblfungi:YNL068C_mRNA(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003682"(chromatin binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0032298"(positive regulation of DNA-dependent DNA replication initiation)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0061186"(negative regulation of silent mating-type cassette heterochromatin assembly)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071930"(negative regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0090282"(positive regulation of transcription involved in G2/M transition of mitotic cell cycle)|go:"GO:0090419"(negative regulation of transcription involved in G2/M transition of mitotic cell cycle)|go:"GO:1903468"(positive regulation of DNA replication initiation)|go:"GO:2000221"(negative regulation of pseudohyphal growth)|interpro:IPR000253(Forkhead-associated)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR018122|interpro:IPR030456|interpro:IPR036388|interpro:IPR036390 ensemblfungi:YMR001C(gene)|ensemblfungi:YMR001C_mRNA(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000922"(spindle pole)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005816"(spindle pole body)|go:"GO:0005935"(cellular bud neck)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0010458"(exit from mitosis)|go:"GO:0010696"(positive regulation of mitotic spindle pole body separation)|go:"GO:0019237"(centromeric DNA binding)|refseq:NP_013714.1|sgd:S000004603|reactome:R-SCE-6804115|reactome:R-SCE-156711|reactome:R-SCE-162658|reactome:R-SCE-2565942|dip:DIP-2321N|reactome:R-SCE-2500257|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051301"(cell division)|go:"GO:0070194"(synaptonemal complex disassembly)|go:"GO:0090306"(meiotic spindle assembly)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0110083"(positive regulation of protein localization to cell division site involved in mitotic actomyosin contractile ring assembly)|go:"GO:1902542"(regulation of protein localization to mitotic spindle pole body)|go:"GO:1903353"(regulation of nucleus organization)|go:"GO:1904750"(negative regulation of protein localization to nucleolus)|go:"GO:1905339"(positive regulation of cohesin unloading)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000959(POLO box duplicated region)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033695|interpro:IPR033701|interpro:IPR036947|rcsb pdb:6MF4|rcsb pdb:6MF5|rcsb pdb:6MF6 psi-mi:"MI:0465"(dip) crc64:68A03F5EB7BB5CF3 crc64:B5A25F1BBBEAA3DC full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:6NOwXoT9V9FWsfmDBREwsi7+oBI559292 rogid:XXSkltYvBA9Zkh0Kr5s1znazUC0559292 rigid:sEenvHNFVv191AahD6qpzi2vPQ4 false 35s radiolabel:?-? glutathione s tranferase tag:n-n - - psi-mi:"MI:0833"(autoradiography) psi-mi:"MI:0833"(autoradiography) uniprotkb:P41813 uniprotkb:P32562 intact:EBI-6973|uniprotkb:D6W1B1|ensemblfungi:YNL068C intact:EBI-4440|ensemblfungi:YMR001C|uniprotkb:D6VZH5 psi-mi:fkh2_yeast(display_long)|uniprotkb:N2403(orf name)|uniprotkb:YNL2403C(orf name)|uniprotkb:YNL068C(locus name)|uniprotkb:FKH2(gene name)|psi-mi:FKH2(display_short) psi-mi:cdc5_yeast(display_long)|uniprotkb:CDC5(gene name)|psi-mi:CDC5(display_short)|uniprotkb:MSD2(gene name synonym)|uniprotkb:PKX2(gene name synonym)|uniprotkb:YMR001C(locus name)|uniprotkb:YM8270.03C(orf name) psi-mi:"MI:0424"(protein kinase assay) Darieva et al. (2006) pubmed:17122856|doi:10.1038/nature05339|imex:IM-21615 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0465"(DIP) intact:EBI-15613316|imex:IM-21615-3|dip:DIP-192030E - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) sgd:S000005012|refseq:NP_014331.3|dip:DIP-5944N|mint:P41813|ensemblfungi:YNL068C(gene)|ensemblfungi:YNL068C_mRNA(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003682"(chromatin binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0032298"(positive regulation of DNA-dependent DNA replication initiation)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0061186"(negative regulation of silent mating-type cassette heterochromatin assembly)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071930"(negative regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0090282"(positive regulation of transcription involved in G2/M transition of mitotic cell cycle)|go:"GO:0090419"(negative regulation of transcription involved in G2/M transition of mitotic cell cycle)|go:"GO:1903468"(positive regulation of DNA replication initiation)|go:"GO:2000221"(negative regulation of pseudohyphal growth)|interpro:IPR000253(Forkhead-associated)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR018122|interpro:IPR030456|interpro:IPR036388|interpro:IPR036390 ensemblfungi:YMR001C(gene)|ensemblfungi:YMR001C_mRNA(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000922"(spindle pole)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005816"(spindle pole body)|go:"GO:0005935"(cellular bud neck)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0010458"(exit from mitosis)|go:"GO:0010696"(positive regulation of mitotic spindle pole body separation)|go:"GO:0019237"(centromeric DNA binding)|refseq:NP_013714.1|sgd:S000004603|reactome:R-SCE-6804115|reactome:R-SCE-156711|reactome:R-SCE-162658|reactome:R-SCE-2565942|dip:DIP-2321N|reactome:R-SCE-2500257|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051301"(cell division)|go:"GO:0070194"(synaptonemal complex disassembly)|go:"GO:0090306"(meiotic spindle assembly)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0110083"(positive regulation of protein localization to cell division site involved in mitotic actomyosin contractile ring assembly)|go:"GO:1902542"(regulation of protein localization to mitotic spindle pole body)|go:"GO:1903353"(regulation of nucleus organization)|go:"GO:1904750"(negative regulation of protein localization to nucleolus)|go:"GO:1905339"(positive regulation of cohesin unloading)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000959(POLO box duplicated region)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033695|interpro:IPR033701|interpro:IPR036947|rcsb pdb:6MF4|rcsb pdb:6MF5|rcsb pdb:6MF6 psi-mi:"MI:0465"(dip) crc64:68A03F5EB7BB5CF3 crc64:B5A25F1BBBEAA3DC full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:6NOwXoT9V9FWsfmDBREwsi7+oBI559292 rogid:XXSkltYvBA9Zkh0Kr5s1znazUC0559292 rigid:sEenvHNFVv191AahD6qpzi2vPQ4 false sufficient binding region:458-862 glutathione s tranferase tag:n-n - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:P47113 uniprotkb:P32562 intact:EBI-3586|uniprotkb:D6VWM4|ensemblfungi:YJR053W intact:EBI-4440|ensemblfungi:YMR001C|uniprotkb:D6VZH5 psi-mi:bfa1_yeast(display_long)|uniprotkb:Cell cycle arrest protein BFA1(gene name synonym)|uniprotkb:BFA1(gene name)|psi-mi:BFA1(display_short)|uniprotkb:YJR053W(locus name)|uniprotkb:J1667(orf name) psi-mi:cdc5_yeast(display_long)|uniprotkb:CDC5(gene name)|psi-mi:CDC5(display_short)|uniprotkb:MSD2(gene name synonym)|uniprotkb:PKX2(gene name synonym)|uniprotkb:YMR001C(locus name)|uniprotkb:YM8270.03C(orf name) psi-mi:"MI:0424"(protein kinase assay) Darieva et al. (2006) pubmed:17122856|doi:10.1038/nature05339|imex:IM-21615 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0465"(DIP) intact:EBI-15613297|imex:IM-21615-2|dip:DIP-17591E - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) sgd:S000003814|refseq:NP_012587.3|dip:DIP-4825N|mint:P47113|ensemblfungi:YJR053W(gene)|ensemblfungi:YJR053W_mRNA(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0001100"(negative regulation of exit from mitosis)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005816"(spindle pole body)|go:"GO:0031578"(mitotic spindle orientation checkpoint signaling)|go:"GO:0044732"(mitotic spindle pole body)|go:"GO:0046578"(regulation of Ras protein signal transduction)|go:"GO:0051301"(cell division)|go:"GO:1990334"(Bfa1-Bub2 complex)|interpro:IPR034586 ensemblfungi:YMR001C(gene)|ensemblfungi:YMR001C_mRNA(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000922"(spindle pole)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005816"(spindle pole body)|go:"GO:0005935"(cellular bud neck)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0010458"(exit from mitosis)|go:"GO:0010696"(positive regulation of mitotic spindle pole body separation)|go:"GO:0019237"(centromeric DNA binding)|refseq:NP_013714.1|sgd:S000004603|reactome:R-SCE-6804115|reactome:R-SCE-156711|reactome:R-SCE-162658|reactome:R-SCE-2565942|dip:DIP-2321N|reactome:R-SCE-2500257|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051301"(cell division)|go:"GO:0070194"(synaptonemal complex disassembly)|go:"GO:0090306"(meiotic spindle assembly)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0110083"(positive regulation of protein localization to cell division site involved in mitotic actomyosin contractile ring assembly)|go:"GO:1902542"(regulation of protein localization to mitotic spindle pole body)|go:"GO:1903353"(regulation of nucleus organization)|go:"GO:1904750"(negative regulation of protein localization to nucleolus)|go:"GO:1905339"(positive regulation of cohesin unloading)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000959(POLO box duplicated region)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033695|interpro:IPR033701|interpro:IPR036947|rcsb pdb:6MF4|rcsb pdb:6MF5|rcsb pdb:6MF6 psi-mi:"MI:0465"(dip) crc64:1EA75D26FCF041DA crc64:B5A25F1BBBEAA3DC full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:+J/c8Kt9mA/BgFlxHwBvNKuor5U559292 rogid:XXSkltYvBA9Zkh0Kr5s1znazUC0559292 rigid:vHjsucVrJ1/r08ZTUXoJEJOM/s4 false - glutathione s tranferase tag:n-n - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:Q08887 uniprotkb:P32562 intact:EBI-37269|uniprotkb:D6W365|ensemblfungi:YOR372C intact:EBI-4440|ensemblfungi:YMR001C|uniprotkb:D6VZH5 psi-mi:ndd1_yeast(display_long)|uniprotkb:NDD1(gene name)|psi-mi:NDD1(display_short)|uniprotkb:YOR372C(locus name) psi-mi:cdc5_yeast(display_long)|uniprotkb:CDC5(gene name)|psi-mi:CDC5(display_short)|uniprotkb:MSD2(gene name synonym)|uniprotkb:PKX2(gene name synonym)|uniprotkb:YMR001C(locus name)|uniprotkb:YM8270.03C(orf name) psi-mi:"MI:0424"(protein kinase assay) Darieva et al. (2006) pubmed:17122856|doi:10.1038/nature05339|imex:IM-21615 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0465"(DIP) intact:EBI-15613338|imex:IM-21615-4|dip:DIP-192031E - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) sgd:S000005899|refseq:NP_015017.1|dip:DIP-1806N|ensemblfungi:YOR372C(gene)|ensemblfungi:YOR372C_mRNA(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0090282"(positive regulation of transcription involved in G2/M transition of mitotic cell cycle) ensemblfungi:YMR001C(gene)|ensemblfungi:YMR001C_mRNA(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000922"(spindle pole)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005816"(spindle pole body)|go:"GO:0005935"(cellular bud neck)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0010458"(exit from mitosis)|go:"GO:0010696"(positive regulation of mitotic spindle pole body separation)|go:"GO:0019237"(centromeric DNA binding)|refseq:NP_013714.1|sgd:S000004603|reactome:R-SCE-6804115|reactome:R-SCE-156711|reactome:R-SCE-162658|reactome:R-SCE-2565942|dip:DIP-2321N|reactome:R-SCE-2500257|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051301"(cell division)|go:"GO:0070194"(synaptonemal complex disassembly)|go:"GO:0090306"(meiotic spindle assembly)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0110083"(positive regulation of protein localization to cell division site involved in mitotic actomyosin contractile ring assembly)|go:"GO:1902542"(regulation of protein localization to mitotic spindle pole body)|go:"GO:1903353"(regulation of nucleus organization)|go:"GO:1904750"(negative regulation of protein localization to nucleolus)|go:"GO:1905339"(positive regulation of cohesin unloading)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000959(POLO box duplicated region)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033695|interpro:IPR033701|interpro:IPR036947|rcsb pdb:6MF4|rcsb pdb:6MF5|rcsb pdb:6MF6 psi-mi:"MI:0465"(dip) crc64:1CF99115F2B1F23D crc64:B5A25F1BBBEAA3DC full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:Xwnt6vMDs0OfMOSVo5Uj4JHg6rg559292 rogid:XXSkltYvBA9Zkh0Kr5s1znazUC0559292 rigid:u9IZavYD1RBUtihJFUF1pOGJEYk false O-phospho-L-serine:85-85|mutation decreasing interaction rate:85-85 glutathione s tranferase tag:n-n - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)