#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P63000-1 uniprotkb:Q00722 intact:EBI-7212896|uniprotkb:P15154-1|intact:MINT-124079|ensembl:ENSP00000258737 intact:EBI-968381|ensembl:ENSP00000260402|uniprotkb:A8K6J2|uniprotkb:B9EGH5 psi-mi:p63000-1(display_long)|uniprotkb:RAC1(gene name)|psi-mi:RAC1(display_short)|uniprotkb:Cell migration-inducing gene 5 protein(gene name synonym)|uniprotkb:Ras-like protein TC25(gene name synonym)|uniprotkb:TC25(gene name synonym)|uniprotkb:p21-Rac1(gene name synonym)|uniprotkb:MIG5(orf name)|uniprotkb:Rac1A(isoform synonym) psi-mi:plcb2_human(display_long)|uniprotkb:PLCB2(gene name)|psi-mi:PLCB2(display_short)|uniprotkb:Phosphoinositide phospholipase C-beta-2(gene name synonym)|uniprotkb:Phospholipase C-beta-2(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) Jezyk et al. (2006) pubmed:17115053|doi:10.1038/nsmb1175|imex:IM-8605 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15612939|imex:IM-8605-1|dip:DIP-57286E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-413628(isoform-parent)|ensembl:ENSG00000136238(gene)|ensembl:ENST00000348035(transcript) refseq:NP_001271226.1|ensembl:ENSG00000137841(gene)|ensembl:ENST00000260402(transcript)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005829"(cytosol)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0050913"(sensory perception of bitter taste)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR011992(EF-Hand type)|interpro:IPR014815(PLC-beta, C-terminal)|interpro:IPR015359(Phospholipase C, phosphoinositol-specific, EF-hand-like)|interpro:IPR016280(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta)|interpro:IPR017946|interpro:IPR028403|interpro:IPR035892|interpro:IPR037862|rcsb pdb:2FJU|rcsb pdb:2ZKM|reactome:R-HSA-112043|reactome:R-HSA-1855204|reactome:R-HSA-399997|go:"GO:0007202"(activation of phospholipase C activity)|reactome:R-HSA-4086398|reactome:R-HSA-416476|reactome:R-HSA-418217|reactome:R-HSA-434316|reactome:R-HSA-500657|refseq:NP_004564.2|refseq:NP_001271227.1|dip:DIP-29259N psi-mi:"MI:0465"(dip) comment:mint - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:8rkYyZSFL5tIfbRNKZgP/UDxD+A9606 rogid:Ef8OWTNQ9Mbw1r4NKGu6t29rTi09606 rigid:icKS2R9kfEdKyMDdShEXHQDKiF8 false sufficient binding region:1-189 sufficient binding region:1-799 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)