#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:O70468 uniprotkb:Q02566 intact:EBI-8347074|uniprotkb:O88997|intact:MINT-4102925 intact:EBI-299157|ensembl:ENSMUSP00000080538|ensembl:ENSMUSP00000154634|uniprotkb:Q64258|uniprotkb:Q64738 psi-mi:mypc3_mouse(display_long)|uniprotkb:Mybpc3(gene name)|psi-mi:Mybpc3(display_short)|uniprotkb:C-protein, cardiac muscle isoform(gene name synonym) psi-mi:myh6_mouse(display_long)|uniprotkb:Myh6(gene name)|psi-mi:Myh6(display_short)|uniprotkb:Myhca(gene name synonym)|uniprotkb:Myosin heavy chain 6(gene name synonym)|uniprotkb:Myosin heavy chain, cardiac muscle alpha isoform(gene name synonym) psi-mi:"MI:0018"(two hybrid) Sadayappan et al. (2006) pubmed:17075052|doi:10.1073/pnas.0607069103|imex:IM-23960 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15608724|imex:IM-23960-1|dip:DIP-198188E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-48624N|mint:O70468|go:"GO:0002027"(regulation of heart rate)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005863"(striated muscle myosin thick filament)|go:"GO:0006936"(muscle contraction)|go:"GO:0007155"(cell adhesion)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0017022"(myosin binding)|go:"GO:0030016"(myofibril)|go:"GO:0030017"(sarcomere)|go:"GO:0031034"(myosin filament assembly)|go:"GO:0031672"(A band)|go:"GO:0032036"(myosin heavy chain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045214"(sarcomere organization)|go:"GO:0046872"(metal ion binding)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0097512"(cardiac myofibril)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR040849|rcsb pdb:4EDQ|reactome:R-MMU-390522|interpro:IPR036116 go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060420"(regulation of heart growth)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR002928(Myosin tail)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR008989(Myosin S1 fragment, N-terminal)|ensembl:ENSMUSG00000040752(gene)|ensembl:ENSMUST00000081857(transcript)|interpro:IPR014751(DNA double-strand break repair and VJ recombination XRCC4, C-terminal)|ensembl:ENSMUST00000226297(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001725"(stress fiber)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005859"(muscle myosin complex)|go:"GO:0006936"(muscle contraction)|go:"GO:0006941"(striated muscle contraction)|go:"GO:0007512"(adult heart development)|go:"GO:0007522"(visceral muscle development)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016459"(myosin complex)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030016"(myofibril)|go:"GO:0030018"(Z disc)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030049"(muscle filament sliding)|go:"GO:0030239"(myofibril assembly)|go:"GO:0030899"(calcium-dependent ATPase activity)|go:"GO:0032982"(myosin filament)|go:"GO:0042802"(identical protein binding)|go:"GO:0043462"(regulation of ATP-dependent activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045214"(sarcomere organization)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0051015"(actin filament binding)|go:"GO:0055009"(atrial cardiac muscle tissue morphogenesis)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0055013"(cardiac muscle cell development)|interpro:IPR027417|interpro:IPR036961|mint:Q02566|reactome:R-MMU-390522|refseq:NP_001157643.1|refseq:NP_034986.1|dip:DIP-31385N psi-mi:"MI:0465"(dip) comment:mint|function:Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/05 2017/08/10 rogid:vI2kpFA8OvFOUUaWDlX5bEeTjZY10090 rogid:JJMGyUqbae2GxaIUutuuGtKmew810090 rigid:8D44LAvla9rRMz92uyVC01664oM false sufficient binding region:151-448 sufficient binding region:839-964 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O70468 uniprotkb:Q02566 intact:EBI-8347074|uniprotkb:O88997|intact:MINT-4102925 intact:EBI-299157|ensembl:ENSMUSP00000080538|ensembl:ENSMUSP00000154634|uniprotkb:Q64258|uniprotkb:Q64738 psi-mi:mypc3_mouse(display_long)|uniprotkb:Mybpc3(gene name)|psi-mi:Mybpc3(display_short)|uniprotkb:C-protein, cardiac muscle isoform(gene name synonym) psi-mi:myh6_mouse(display_long)|uniprotkb:Myh6(gene name)|psi-mi:Myh6(display_short)|uniprotkb:Myhca(gene name synonym)|uniprotkb:Myosin heavy chain 6(gene name synonym)|uniprotkb:Myosin heavy chain, cardiac muscle alpha isoform(gene name synonym) psi-mi:"MI:0096"(pull down) Sadayappan et al. (2006) pubmed:17075052|doi:10.1073/pnas.0607069103|imex:IM-23960 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15608745|imex:IM-23960-2|dip:DIP-198188E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-48624N|mint:O70468|go:"GO:0002027"(regulation of heart rate)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005863"(striated muscle myosin thick filament)|go:"GO:0006936"(muscle contraction)|go:"GO:0007155"(cell adhesion)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0017022"(myosin binding)|go:"GO:0030016"(myofibril)|go:"GO:0030017"(sarcomere)|go:"GO:0031034"(myosin filament assembly)|go:"GO:0031672"(A band)|go:"GO:0032036"(myosin heavy chain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045214"(sarcomere organization)|go:"GO:0046872"(metal ion binding)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0097512"(cardiac myofibril)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR040849|rcsb pdb:4EDQ|reactome:R-MMU-390522|interpro:IPR036116 go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060420"(regulation of heart growth)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR002928(Myosin tail)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR008989(Myosin S1 fragment, N-terminal)|ensembl:ENSMUSG00000040752(gene)|ensembl:ENSMUST00000081857(transcript)|interpro:IPR014751(DNA double-strand break repair and VJ recombination XRCC4, C-terminal)|ensembl:ENSMUST00000226297(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001725"(stress fiber)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005859"(muscle myosin complex)|go:"GO:0006936"(muscle contraction)|go:"GO:0006941"(striated muscle contraction)|go:"GO:0007512"(adult heart development)|go:"GO:0007522"(visceral muscle development)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016459"(myosin complex)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030016"(myofibril)|go:"GO:0030018"(Z disc)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030049"(muscle filament sliding)|go:"GO:0030239"(myofibril assembly)|go:"GO:0030899"(calcium-dependent ATPase activity)|go:"GO:0032982"(myosin filament)|go:"GO:0042802"(identical protein binding)|go:"GO:0043462"(regulation of ATP-dependent activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045214"(sarcomere organization)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0051015"(actin filament binding)|go:"GO:0055009"(atrial cardiac muscle tissue morphogenesis)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0055013"(cardiac muscle cell development)|interpro:IPR027417|interpro:IPR036961|mint:Q02566|reactome:R-MMU-390522|refseq:NP_001157643.1|refseq:NP_034986.1|dip:DIP-31385N psi-mi:"MI:0465"(dip) comment:mint|function:Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:vI2kpFA8OvFOUUaWDlX5bEeTjZY10090 rogid:JJMGyUqbae2GxaIUutuuGtKmew810090 rigid:8D44LAvla9rRMz92uyVC01664oM false sufficient binding region:151-448|his tag:n-n - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)