#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P08839	uniprotkb:P0AA04	intact:EBI-551533|ensemblbacteria:AAC75469|ensemblbacteria:BAA16290	intact:EBI-902853|uniprotkb:P05525|uniprotkb:P07006|ensemblbacteria:AAC75468|ensemblbacteria:BAA16289	psi-mi:pt1_ecoli(display_long)|uniprotkb:Phosphotransferase system, enzyme I(gene name synonym)|uniprotkb:ptsI(gene name)|psi-mi:ptsI(display_short)|uniprotkb:b2416(locus name)|uniprotkb:JW2409(locus name)	psi-mi:pthp_ecoli(display_long)|uniprotkb:ptsH(gene name)|psi-mi:ptsH(display_short)|uniprotkb:hpr(gene name synonym)|uniprotkb:b2415(locus name)|uniprotkb:Histidine-containing protein(gene name synonym)|uniprotkb:JW2408(locus name)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Tang et al. (2006)	pubmed:17051159|doi:10.1038/nature05201|imex:IM-21444	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15606916|imex:IM-21444-1|dip:DIP-64656E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_416911.1|refseq:WP_000623140.1|dip:DIP-10603N|ensemblbacteria:AAC75469(transcript)|ensemblbacteria:b2416(gene)|ensemblbacteria:BAA16290(gene)|ensemblbacteria:BAA16290(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0005829"(cytosol)|go:"GO:0008965"(phosphoenolpyruvate-protein phosphotransferase activity)|go:"GO:0009401"(phosphoenolpyruvate-dependent sugar phosphotransferase system)|go:"GO:0016301"(kinase activity)|go:"GO:0019197"(phosphoenolpyruvate-dependent sugar phosphotransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR000121(PEP-utilizing enzyme)|interpro:IPR006318(Phosphoenolpyruvate-protein phosphotransferase)|interpro:IPR008279(PEP-utilising enzyme, mobile region)|interpro:IPR008731(Phosphotransferase system, PEP-utilising enzyme, N-terminal)|interpro:IPR015813(Pyruvate/Phosphoenolpyruvate kinase, catalytic core)|interpro:IPR018274|interpro:IPR023151|interpro:IPR024692|interpro:IPR036618|interpro:IPR036637|interpro:IPR040442|rcsb pdb:1EZA|rcsb pdb:1EZB|rcsb pdb:1EZC|rcsb pdb:1EZD|rcsb pdb:1ZYM|rcsb pdb:2EZA|rcsb pdb:2EZB|rcsb pdb:2EZC|rcsb pdb:2HWG|rcsb pdb:2KX9|rcsb pdb:2L5H|rcsb pdb:2MP0|rcsb pdb:2N5T|rcsb pdb:2XDF|rcsb pdb:3EZA|rcsb pdb:3EZB|rcsb pdb:3EZE|rcsb pdb:6V9K|rcsb pdb:6VU0	refseq:WP_000487600.1|refseq:NP_416910.1|dip:DIP-35731N|ensemblbacteria:AAC75468(transcript)|ensemblbacteria:b2415(gene)|ensemblbacteria:BAA16289(gene)|ensemblbacteria:BAA16289(transcript)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005829"(cytosol)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0009401"(phosphoenolpyruvate-dependent sugar phosphotransferase system)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0045152"(antisigma factor binding)|go:"GO:0045819"(positive regulation of glycogen catabolic process)|interpro:IPR000032(Phosphotransferase system, phosphocarrier HPr protein)|interpro:IPR001020(Phosphotransferase system, HPr histidine phosphorylation site)|interpro:IPR002114(Phosphotransferase system, HPr serine phosphorylation site)|interpro:IPR035895|rcsb pdb:1CM2|rcsb pdb:1CM3|rcsb pdb:1GGR|rcsb pdb:1HDN|rcsb pdb:1J6T|rcsb pdb:1OPD|rcsb pdb:1PFH|rcsb pdb:1POH|rcsb pdb:1VRC|rcsb pdb:2JEL|rcsb pdb:2LRK|rcsb pdb:2LRL|rcsb pdb:2XDF|rcsb pdb:3CCD|rcsb pdb:3EZA|rcsb pdb:3EZB|rcsb pdb:3EZE|rcsb pdb:4XWJ|rcsb pdb:5YA0|rcsb pdb:5YA1|rcsb pdb:5YA2|rcsb pdb:6KCR	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:BwIcA0MNQT9nJLVY3IUbzEi0hig83333	rogid:PclWk4uLFrEfcs8pGZ3juGqwvzc83333	rigid:vVFs1nn3VqBH1pOzapL4DK3JjDQ	false	sufficient binding region:1-258	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P69797	uniprotkb:P0AA04	intact:EBI-554089|uniprotkb:P08186|uniprotkb:Q47350|ensemblbacteria:AAC74887|ensemblbacteria:BAA15624	intact:EBI-902853|uniprotkb:P05525|uniprotkb:P07006|ensemblbacteria:AAC75468|ensemblbacteria:BAA16289	psi-mi:ptnab_ecoli(display_long)|uniprotkb:EIIAB-Man(gene name synonym)|uniprotkb:manX(gene name)|psi-mi:manX(display_short)|uniprotkb:gptB(gene name synonym)|uniprotkb:ptsL(gene name synonym)|uniprotkb:b1817(locus name)|uniprotkb:JW1806(locus name)|uniprotkb:EIII-Man(gene name synonym)	psi-mi:pthp_ecoli(display_long)|uniprotkb:ptsH(gene name)|psi-mi:ptsH(display_short)|uniprotkb:hpr(gene name synonym)|uniprotkb:b2415(locus name)|uniprotkb:Histidine-containing protein(gene name synonym)|uniprotkb:JW2408(locus name)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Tang et al. (2006)	pubmed:17051159|doi:10.1038/nature05201|imex:IM-21444	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15606935|imex:IM-21444-2|dip:DIP-191600E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_416331.1|refseq:WP_000150543.1|dip:DIP-35846N|mint:P69797|ensemblbacteria:AAC74887(transcript)|ensemblbacteria:b1817(gene)|ensemblbacteria:BAA15624(gene)|ensemblbacteria:BAA15624(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0009401"(phosphoenolpyruvate-dependent sugar phosphotransferase system)|go:"GO:0015761"(mannose transmembrane transport)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0022870"("protein-N(PI)-phosphohistidine-mannose phosphotransferase system transporter activity")|go:"GO:0098708"(glucose import across plasma membrane)|interpro:IPR004701(Phosphotransferase system, fructose subfamily IIA component)|interpro:IPR004720(Phosphotransferase system, sorbose subfamily IIB component)|interpro:IPR013789(Phosphotransferase system, fructose subfamily IIA component, subgroup)|interpro:IPR018455|interpro:IPR033887|interpro:IPR036662|interpro:IPR036667|rcsb pdb:1PDO|rcsb pdb:1VRC|rcsb pdb:1VSQ|rcsb pdb:2JZH|rcsb pdb:2JZN|rcsb pdb:2JZO	refseq:WP_000487600.1|refseq:NP_416910.1|dip:DIP-35731N|ensemblbacteria:AAC75468(transcript)|ensemblbacteria:b2415(gene)|ensemblbacteria:BAA16289(gene)|ensemblbacteria:BAA16289(transcript)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005829"(cytosol)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0009401"(phosphoenolpyruvate-dependent sugar phosphotransferase system)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0045152"(antisigma factor binding)|go:"GO:0045819"(positive regulation of glycogen catabolic process)|interpro:IPR000032(Phosphotransferase system, phosphocarrier HPr protein)|interpro:IPR001020(Phosphotransferase system, HPr histidine phosphorylation site)|interpro:IPR002114(Phosphotransferase system, HPr serine phosphorylation site)|interpro:IPR035895|rcsb pdb:1CM2|rcsb pdb:1CM3|rcsb pdb:1GGR|rcsb pdb:1HDN|rcsb pdb:1J6T|rcsb pdb:1OPD|rcsb pdb:1PFH|rcsb pdb:1POH|rcsb pdb:1VRC|rcsb pdb:2JEL|rcsb pdb:2LRK|rcsb pdb:2LRL|rcsb pdb:2XDF|rcsb pdb:3CCD|rcsb pdb:3EZA|rcsb pdb:3EZB|rcsb pdb:3EZE|rcsb pdb:4XWJ|rcsb pdb:5YA0|rcsb pdb:5YA1|rcsb pdb:5YA2|rcsb pdb:6KCR	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:y85TszAJoItnfaihrmNkeHIQyo083333	rogid:PclWk4uLFrEfcs8pGZ3juGqwvzc83333	rigid:Ywk8LPH18SB/sypVerhKCeqzeqA	false	sufficient binding region:1-136	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P00550	uniprotkb:P0AA04	intact:EBI-547239|uniprotkb:Q2M7R2|ensemblbacteria:AAC76623|ensemblbacteria:BAE77694	intact:EBI-902853|uniprotkb:P05525|uniprotkb:P07006|ensemblbacteria:AAC75468|ensemblbacteria:BAA16289	psi-mi:ptm3c_ecoli(display_long)|uniprotkb:mtlA(gene name)|psi-mi:mtlA(display_short)|uniprotkb:b3599(locus name)|uniprotkb:EIICBA-Mtl(gene name synonym)|uniprotkb:JW3573(locus name)	psi-mi:pthp_ecoli(display_long)|uniprotkb:ptsH(gene name)|psi-mi:ptsH(display_short)|uniprotkb:hpr(gene name synonym)|uniprotkb:b2415(locus name)|uniprotkb:Histidine-containing protein(gene name synonym)|uniprotkb:JW2408(locus name)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Tang et al. (2006)	pubmed:17051159|doi:10.1038/nature05201|imex:IM-21444	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15606954|imex:IM-21444-3|dip:DIP-191601E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_418056.1|refseq:WP_000093247.1|ensemblbacteria:AAC76623(transcript)|ensemblbacteria:b3599(gene)|ensemblbacteria:BAE77694(gene)|ensemblbacteria:BAE77694(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0009401"(phosphoenolpyruvate-dependent sugar phosphotransferase system)|go:"GO:0015797"(mannitol transport)|go:"GO:0016301"(kinase activity)|go:"GO:0022872"("protein-N(PI)-phosphohistidine-mannitol phosphotransferase system transmembrane transporter activity")|go:"GO:0090563"(protein-phosphocysteine-sugar phosphotransferase activity)|go:"GO:0090565"(protein-phosphocysteine-mannitol phosphotransferase system transporter activity)|interpro:IPR002178(Phosphotransferase system, phosphoenolpyruvate-dependent sugar EIIA 2)|interpro:IPR003352(Phosphotransferase system, EIIC)|interpro:IPR003501(Phosphotransferase system, lactose/cellobiose-specific IIB subunit)|interpro:IPR004718(Phosphotransferase system, mannitol-specific enzyme IIC)|interpro:IPR013011(Phosphotransferase system, EIIB component, type 2)|interpro:IPR013014(Phosphotransferase system, EIIC component, type 2)|interpro:IPR016152(Phosphotransferase/anion transporter)|interpro:IPR029503|interpro:IPR036095|rcsb pdb:1A3A|rcsb pdb:1J6T|rcsb pdb:1VKR|rcsb pdb:1VRV|rcsb pdb:2FEW|dip:DIP-10267N	refseq:WP_000487600.1|refseq:NP_416910.1|dip:DIP-35731N|ensemblbacteria:AAC75468(transcript)|ensemblbacteria:b2415(gene)|ensemblbacteria:BAA16289(gene)|ensemblbacteria:BAA16289(transcript)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005829"(cytosol)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0009401"(phosphoenolpyruvate-dependent sugar phosphotransferase system)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0045152"(antisigma factor binding)|go:"GO:0045819"(positive regulation of glycogen catabolic process)|interpro:IPR000032(Phosphotransferase system, phosphocarrier HPr protein)|interpro:IPR001020(Phosphotransferase system, HPr histidine phosphorylation site)|interpro:IPR002114(Phosphotransferase system, HPr serine phosphorylation site)|interpro:IPR035895|rcsb pdb:1CM2|rcsb pdb:1CM3|rcsb pdb:1GGR|rcsb pdb:1HDN|rcsb pdb:1J6T|rcsb pdb:1OPD|rcsb pdb:1PFH|rcsb pdb:1POH|rcsb pdb:1VRC|rcsb pdb:2JEL|rcsb pdb:2LRK|rcsb pdb:2LRL|rcsb pdb:2XDF|rcsb pdb:3CCD|rcsb pdb:3EZA|rcsb pdb:3EZB|rcsb pdb:3EZE|rcsb pdb:4XWJ|rcsb pdb:5YA0|rcsb pdb:5YA1|rcsb pdb:5YA2|rcsb pdb:6KCR	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:HEPisuXtMZqLfWnS+ZsWKuqhZwo83333	rogid:PclWk4uLFrEfcs8pGZ3juGqwvzc83333	rigid:Qsw8Q4DcnlKeqk3s8baSNBVFxyw	false	sufficient binding region:491-637	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)