#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P35969	uniprotkb:Q00731	intact:EBI-1554752|uniprotkb:O55094|uniprotkb:Q61517	intact:EBI-444774|uniprotkb:O70123|uniprotkb:Q66S31|uniprotkb:Q6GT23|uniprotkb:Q6WZL9	psi-mi:vgfr1_mouse(display_long)|uniprotkb:Tyrosine-protein kinase receptor FLT(gene name synonym)|uniprotkb:Fms-like tyrosine kinase 1(gene name synonym)|uniprotkb:Embryonic receptor kinase 2(gene name synonym)|uniprotkb:Flt1(gene name)|psi-mi:Flt1(display_short)|uniprotkb:Emrk2(gene name synonym)|uniprotkb:Flt(gene name synonym)|uniprotkb:Vegfr1(gene name synonym)	psi-mi:vegfa_mouse(display_long)|uniprotkb:Vascular permeability factor(gene name synonym)|uniprotkb:Vegfa(gene name)|psi-mi:Vegfa(display_short)|uniprotkb:Vegf(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Ambati et al. (2006)	pubmed:17051153|doi:10.1038/nature05249|imex:IM-21446	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15606889|imex:IM-21446-1|dip:DIP-191604E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034358.2|mint:P35969|dip:DIP-39359N|go:"GO:0001525"(angiogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005021"(vascular endothelial growth factor-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016477"(cell migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019838"(growth factor binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0036323"(vascular endothelial growth factor receptor-1 signaling pathway)|go:"GO:0036332"(placental growth factor-activated receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048597"(post-embryonic camera-type eye morphogenesis)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:1901534"(positive regulation of hematopoietic progenitor cell differentiation)|go:"GO:1905563"(negative regulation of vascular endothelial cell proliferation)|go:"GO:1990384"(hyaloid vascular plexus regression)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001824(Receptor tyrosine kinase, class III, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009135(Vascular endothelial growth factor receptor 1, VEGFR1, N-terminal)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036179|interpro:IPR041348|reactome:R-MMU-194306|reactome:R-MMU-195399	refseq:NP_001020421.2|refseq:NP_001020428.2|refseq:NP_001103736.1|refseq:NP_001103737.1|refseq:NP_001103738.1|refseq:NP_033531.3|refseq:NP_001303970.1|refseq:NP_001273985.1|refseq:NP_001273986.1|refseq:NP_001273987.1|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001568"(blood vessel development)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001822"(kidney development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001944"(vasculature development)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0001968"(fibronectin binding)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002575"(basophil chemotaxis)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003169"(coronary vein morphogenesis)|go:"GO:0005125"(cytokine activity)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005172"(vascular endothelial growth factor receptor binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0007498"(mesoderm development)|go:"GO:0007595"(lactation)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0010749"(regulation of nitric oxide mediated signal transduction)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016477"(cell migration)|go:"GO:0019838"(growth factor binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030141"(secretory granule)|go:"GO:0030224"(monocyte differentiation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031077"(post-embryonic camera-type eye development)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0031982"(vesicle)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032793"(positive regulation of CREB transcription factor activity)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035148"(tube formation)|go:"GO:0035767"(endothelial cell chemotaxis)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0036303"(lymph vessel morphogenesis)|go:"GO:0036324"(vascular endothelial growth factor receptor-2 signaling pathway)|go:"GO:0038033"(positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway)|go:"GO:0038084"(vascular endothelial growth factor signaling pathway)|go:"GO:0038089"(positive regulation of cell migration by vascular endothelial growth factor signaling pathway)|go:"GO:0038091"(positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway)|go:"GO:0038190"(VEGF-activated neuropilin signaling pathway)|go:"GO:0038191"(neuropilin binding)|go:"GO:0040008"(regulation of growth)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042462"(eye photoreceptor cell development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043117"(positive regulation of vascular permeability)|go:"GO:0043129"(surfactant homeostasis)|go:"GO:0043184"(vascular endothelial growth factor receptor 2 binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045601"(regulation of endothelial cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048469"(cell maturation)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048593"(camera-type eye morphogenesis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048666"(neuron development)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0043183"(vascular endothelial growth factor receptor 1 binding)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0050927"(positive regulation of positive chemotaxis)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0060319"(primitive erythrocyte differentiation)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0060346"(bone trabecula formation)|go:"GO:0060426"(lung vasculature development)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0060754"(positive regulation of mast cell chemotaxis)|go:"GO:0060948"(cardiac vascular smooth muscle cell development)|go:"GO:0060978"(angiogenesis involved in coronary vascular morphogenesis)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0061042"(vascular wound healing)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061430"(bone trabecula morphogenesis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:0090259"(regulation of retinal ganglion cell axon guidance)|go:"GO:0097475"(motor neuron migration)|go:"GO:0097533"(cellular stress response to acid chemical)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1900086"(positive regulation of peptidyl-tyrosine autophosphorylation)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901492"(positive regulation of lymphangiogenesis)|go:"GO:1901532"(regulation of hematopoietic progenitor cell differentiation)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902336"(positive regulation of retinal ganglion cell axon guidance)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1903141"(negative regulation of establishment of endothelial barrier)|go:"GO:1903392"(negative regulation of adherens junction organization)|go:"GO:1903572"(positive regulation of protein kinase D signaling)|go:"GO:1903589"(positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1905278"(positive regulation of epithelial tube formation)|go:"GO:1905604"(negative regulation of blood-brain barrier permeability)|go:"GO:2000048"(negative regulation of cell-cell adhesion mediated by cadherin)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000072("Platelet-derived growth factor (PDGF)")|interpro:IPR023581|interpro:IPR027928|interpro:IPR029034|interpro:IPR036841|go:"GO:0090037"(positive regulation of protein kinase C signaling)|reactome:R-MMU-114608|reactome:R-MMU-194313|reactome:R-MMU-195399|reactome:R-MMU-4420097|reactome:R-MMU-5218921|dip:DIP-31909N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/05	2017/08/10	rogid:h8ZisQ4hFcNEoJwYpnhQ9OCMvcY10090	rogid:zU6IdMrWdycj52MXNBPdDYMtNx410090	rigid:RzNIhuLKcfQyZHjcFsh8fGv24Xg	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)