#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q8TF40-1 uniprotkb:Q8NFG4-1 intact:EBI-15604805|ensembl:ENSP00000421985 intact:EBI-15604776|ensembl:ENSP00000285071 psi-mi:q8tf40-1(display_long)|uniprotkb:FNIP1(gene name)|psi-mi:FNIP1(display_short)|uniprotkb:KIAA1961(gene name synonym) psi-mi:q8nfg4-1(display_long)|uniprotkb:FLCN(gene name)|psi-mi:FLCN(display_short)|uniprotkb:BHD(gene name synonym)|uniprotkb:BHD skin lesion fibrofolliculoma protein(gene name synonym)|uniprotkb:Birt-Hogg-Dube syndrome protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Baba et al. (2006) pubmed:17028174|doi:10.1073/pnas.0603781103|imex:IM-23935 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15604812|imex:IM-23935-2|dip:DIP-198135E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000217128(gene)|ensembl:ENST00000510461(transcript)|intact:EBI-2946919(isoform-parent) ensembl:ENSG00000154803(gene)|ensembl:ENST00000285071(transcript)|intact:EBI-2970160(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/05 2017/08/10 rogid:HVA3rKbb8nS/97UCKVDCje0xTjw9606 rogid:gd59RCSQ6ssRdb2wz+HZl1V5wLY9606 rigid:KDK0P8FvrPnUmLfhRaZlkiRpqCk false flag tag:?-? ha tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q8TF40 uniprotkb:Q8NFG4-1 intact:EBI-2946919|ensembl:ENSP00000421985|uniprotkb:Q9BUT0|uniprotkb:Q86T47|uniprotkb:D6RJH5 intact:EBI-15604776|ensembl:ENSP00000285071 psi-mi:fnip1_human(display_long)|uniprotkb:FNIP1(gene name)|psi-mi:FNIP1(display_short)|uniprotkb:KIAA1961(gene name synonym) psi-mi:q8nfg4-1(display_long)|uniprotkb:FLCN(gene name)|psi-mi:FLCN(display_short)|uniprotkb:BHD(gene name synonym)|uniprotkb:BHD skin lesion fibrofolliculoma protein(gene name synonym)|uniprotkb:Birt-Hogg-Dube syndrome protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Baba et al. (2006) pubmed:17028174|doi:10.1073/pnas.0603781103|imex:IM-23935 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15604784|imex:IM-23935-1|dip:DIP-198135E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000217128(gene)|ensembl:ENST00000510461(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002327"(immature B cell differentiation)|go:"GO:0002904"(positive regulation of B cell apoptotic process)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0019899"(enzyme binding)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031929"(TOR signaling)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0051087"(chaperone binding)|go:"GO:2000973"(regulation of pro-B cell differentiation)|interpro:IPR026156|interpro:IPR028084|interpro:IPR028085|interpro:IPR028086|interpro:IPR037545|mint:Q8TF40|reactome:R-HSA-9639288|go:"GO:0032008"(positive regulation of TOR signaling)|refseq:NP_001008738.2|refseq:NP_588613.2|refseq:NP_001333042.1|dip:DIP-57169N ensembl:ENSG00000154803(gene)|ensembl:ENST00000285071(transcript)|intact:EBI-2970160(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/05 2017/08/10 rogid:HVA3rKbb8nS/97UCKVDCje0xTjw9606 rogid:gd59RCSQ6ssRdb2wz+HZl1V5wLY9606 rigid:KDK0P8FvrPnUmLfhRaZlkiRpqCk false - ha tag:?-? - - psi-mi:"MI:0082"(peptide massfingerprinting) psi-mi:"MI:0082"(peptide massfingerprinting) uniprotkb:Q8TF40-1 uniprotkb:P54619 intact:EBI-15604805|ensembl:ENSP00000421985 intact:EBI-1181439|ensembl:ENSP00000447433|uniprotkb:B4DDT7|uniprotkb:Q8N7V9 psi-mi:q8tf40-1(display_long)|uniprotkb:FNIP1(gene name)|psi-mi:FNIP1(display_short)|uniprotkb:KIAA1961(gene name synonym) psi-mi:aakg1_human(display_long)|uniprotkb:PRKAG1(gene name)|psi-mi:PRKAG1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Baba et al. (2006) pubmed:17028174|doi:10.1073/pnas.0603781103|imex:IM-23935 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15604837|imex:IM-23935-3|dip:DIP-198136E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000217128(gene)|ensembl:ENST00000510461(transcript)|intact:EBI-2946919(isoform-parent) refseq:NP_001193638.1|refseq:NP_001193639.1|refseq:NP_002724.1|refseq:XP_011536864.1|reactome:R-HSA-9619483|reactome:R-HSA-9613354|ensembl:ENSG00000181929(gene)|ensembl:ENST00000548065(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004691"(cAMP-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006110"(regulation of glycolytic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008603"(cAMP-dependent protein kinase regulator activity)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016208"(AMP binding)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043531"(ADP binding)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051170"(import into nucleus)|go:"GO:0071900"(regulation of protein serine/threonine kinase activity)|interpro:IPR000644(Cystathionine beta-synthase, core)|interpro:IPR039166|mint:P54619|rcsb pdb:2UV4|rcsb pdb:2UV5|rcsb pdb:2UV6|rcsb pdb:2UV7|rcsb pdb:4CFE|rcsb pdb:4CFF|rcsb pdb:4RER|rcsb pdb:4REW|rcsb pdb:4ZHX|rcsb pdb:5EZV|rcsb pdb:5ISO|rcsb pdb:6B1U|rcsb pdb:6B2E|rcsb pdb:6C9F|rcsb pdb:6C9G|rcsb pdb:6C9H|rcsb pdb:6C9J|reactome:R-HSA-1445148|reactome:R-HSA-1632852|reactome:R-HSA-2151209|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6804756|refseq:XP_006719562.1|dip:DIP-39974N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/05 2017/08/10 rogid:HVA3rKbb8nS/97UCKVDCje0xTjw9606 rogid:JNBzPdCbcgr37RKb2sk6yVL+7649606 rigid:EOPYtLZl0o42VwQOZ/+0atzSWAQ false ha tag:?-? - - - psi-mi:"MI:0082"(peptide massfingerprinting) psi-mi:"MI:0082"(peptide massfingerprinting) uniprotkb:Q8TF40-1 uniprotkb:Q8NFG4-1 intact:EBI-15604805|ensembl:ENSP00000421985 intact:EBI-15604776|ensembl:ENSP00000285071 psi-mi:q8tf40-1(display_long)|uniprotkb:FNIP1(gene name)|psi-mi:FNIP1(display_short)|uniprotkb:KIAA1961(gene name synonym) psi-mi:q8nfg4-1(display_long)|uniprotkb:FLCN(gene name)|psi-mi:FLCN(display_short)|uniprotkb:BHD(gene name synonym)|uniprotkb:BHD skin lesion fibrofolliculoma protein(gene name synonym)|uniprotkb:Birt-Hogg-Dube syndrome protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Baba et al. (2006) pubmed:17028174|doi:10.1073/pnas.0603781103|imex:IM-23935 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15604837|imex:IM-23935-3|dip:DIP-198136E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000217128(gene)|ensembl:ENST00000510461(transcript)|intact:EBI-2946919(isoform-parent) ensembl:ENSG00000154803(gene)|ensembl:ENST00000285071(transcript)|intact:EBI-2970160(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/05 2017/08/10 rogid:HVA3rKbb8nS/97UCKVDCje0xTjw9606 rogid:gd59RCSQ6ssRdb2wz+HZl1V5wLY9606 rigid:EOPYtLZl0o42VwQOZ/+0atzSWAQ false ha tag:?-? - - - psi-mi:"MI:0082"(peptide massfingerprinting) psi-mi:"MI:0082"(peptide massfingerprinting) uniprotkb:Q8TF40 uniprotkb:Q8NFG4 intact:EBI-2946919|ensembl:ENSP00000421985|uniprotkb:Q9BUT0|uniprotkb:Q86T47|uniprotkb:D6RJH5 intact:EBI-2970160|ensembl:ENSP00000285071|uniprotkb:Q96BD2|uniprotkb:Q96BE4|uniprotkb:A6NJJ8|uniprotkb:Q6ZRX1 psi-mi:fnip1_human(display_long)|uniprotkb:FNIP1(gene name)|psi-mi:FNIP1(display_short)|uniprotkb:KIAA1961(gene name synonym) psi-mi:flcn_human(display_long)|uniprotkb:FLCN(gene name)|psi-mi:FLCN(display_short)|uniprotkb:BHD(gene name synonym)|uniprotkb:BHD skin lesion fibrofolliculoma protein(gene name synonym)|uniprotkb:Birt-Hogg-Dube syndrome protein(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Baba et al. (2006) pubmed:17028174|doi:10.1073/pnas.0603781103|imex:IM-23935 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15604936|imex:IM-23935-7|dip:DIP-198135E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000217128(gene)|ensembl:ENST00000510461(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002327"(immature B cell differentiation)|go:"GO:0002904"(positive regulation of B cell apoptotic process)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0019899"(enzyme binding)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031929"(TOR signaling)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0051087"(chaperone binding)|go:"GO:2000973"(regulation of pro-B cell differentiation)|interpro:IPR026156|interpro:IPR028084|interpro:IPR028085|interpro:IPR028086|interpro:IPR037545|mint:Q8TF40|reactome:R-HSA-9639288|go:"GO:0032008"(positive regulation of TOR signaling)|refseq:NP_001008738.2|refseq:NP_588613.2|refseq:NP_001333042.1|dip:DIP-57169N go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010823"(negative regulation of mitochondrion organization)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031929"(TOR signaling)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035065"(regulation of histone acetylation)|go:"GO:0005737"(cytoplasm)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046578"(regulation of Ras protein signal transduction)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0072686"(mitotic spindle)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:1901723"(negative regulation of cell proliferation involved in kidney development)|go:"GO:1903444"(negative regulation of brown fat cell differentiation)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:2000973"(regulation of pro-B cell differentiation)|go:"GO:2001170"(negative regulation of ATP biosynthetic process)|interpro:IPR021713|interpro:IPR032035|interpro:IPR037520|interpro:IPR037521|interpro:IPR044886|rcsb pdb:3V42|rcsb pdb:6NZD|rcsb pdb:6ULG|reactome:R-HSA-9639288|ensembl:ENSG00000154803(gene)|ensembl:ENST00000285071(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|refseq:NP_653207.1|refseq:NP_659434.2|refseq:XP_016879795.1|refseq:XP_016879796.1|refseq:XP_016879797.1|dip:DIP-61287N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/05 2017/08/10 rogid:HVA3rKbb8nS/97UCKVDCje0xTjw9606 rogid:gd59RCSQ6ssRdb2wz+HZl1V5wLY9606 rigid:KDK0P8FvrPnUmLfhRaZlkiRpqCk false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8TF40-1 uniprotkb:Q8NFG4 intact:EBI-15604805|ensembl:ENSP00000421985 intact:EBI-2970160|ensembl:ENSP00000285071|uniprotkb:Q96BD2|uniprotkb:Q96BE4|uniprotkb:A6NJJ8|uniprotkb:Q6ZRX1 psi-mi:q8tf40-1(display_long)|uniprotkb:FNIP1(gene name)|psi-mi:FNIP1(display_short)|uniprotkb:KIAA1961(gene name synonym) psi-mi:flcn_human(display_long)|uniprotkb:FLCN(gene name)|psi-mi:FLCN(display_short)|uniprotkb:BHD(gene name synonym)|uniprotkb:BHD skin lesion fibrofolliculoma protein(gene name synonym)|uniprotkb:Birt-Hogg-Dube syndrome protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Baba et al. (2006) pubmed:17028174|doi:10.1073/pnas.0603781103|imex:IM-23935 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15604953|imex:IM-23935-8|dip:DIP-198136E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000217128(gene)|ensembl:ENST00000510461(transcript)|intact:EBI-2946919(isoform-parent) go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010823"(negative regulation of mitochondrion organization)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031929"(TOR signaling)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035065"(regulation of histone acetylation)|go:"GO:0005737"(cytoplasm)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046578"(regulation of Ras protein signal transduction)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0072686"(mitotic spindle)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:1901723"(negative regulation of cell proliferation involved in kidney development)|go:"GO:1903444"(negative regulation of brown fat cell differentiation)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:2000973"(regulation of pro-B cell differentiation)|go:"GO:2001170"(negative regulation of ATP biosynthetic process)|interpro:IPR021713|interpro:IPR032035|interpro:IPR037520|interpro:IPR037521|interpro:IPR044886|rcsb pdb:3V42|rcsb pdb:6NZD|rcsb pdb:6ULG|reactome:R-HSA-9639288|ensembl:ENSG00000154803(gene)|ensembl:ENST00000285071(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|refseq:NP_653207.1|refseq:NP_659434.2|refseq:XP_016879795.1|refseq:XP_016879796.1|refseq:XP_016879797.1|dip:DIP-61287N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/05 2017/08/10 rogid:HVA3rKbb8nS/97UCKVDCje0xTjw9606 rogid:gd59RCSQ6ssRdb2wz+HZl1V5wLY9606 rigid:EOPYtLZl0o42VwQOZ/+0atzSWAQ false ha tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8TF40-1 uniprotkb:P54619 intact:EBI-15604805|ensembl:ENSP00000421985 intact:EBI-1181439|ensembl:ENSP00000447433|uniprotkb:B4DDT7|uniprotkb:Q8N7V9 psi-mi:q8tf40-1(display_long)|uniprotkb:FNIP1(gene name)|psi-mi:FNIP1(display_short)|uniprotkb:KIAA1961(gene name synonym) psi-mi:aakg1_human(display_long)|uniprotkb:PRKAG1(gene name)|psi-mi:PRKAG1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Baba et al. (2006) pubmed:17028174|doi:10.1073/pnas.0603781103|imex:IM-23935 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15604953|imex:IM-23935-8|dip:DIP-198136E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000217128(gene)|ensembl:ENST00000510461(transcript)|intact:EBI-2946919(isoform-parent) refseq:NP_001193638.1|refseq:NP_001193639.1|refseq:NP_002724.1|refseq:XP_011536864.1|reactome:R-HSA-9619483|reactome:R-HSA-9613354|ensembl:ENSG00000181929(gene)|ensembl:ENST00000548065(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004691"(cAMP-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006110"(regulation of glycolytic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008603"(cAMP-dependent protein kinase regulator activity)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016208"(AMP binding)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043531"(ADP binding)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051170"(import into nucleus)|go:"GO:0071900"(regulation of protein serine/threonine kinase activity)|interpro:IPR000644(Cystathionine beta-synthase, core)|interpro:IPR039166|mint:P54619|rcsb pdb:2UV4|rcsb pdb:2UV5|rcsb pdb:2UV6|rcsb pdb:2UV7|rcsb pdb:4CFE|rcsb pdb:4CFF|rcsb pdb:4RER|rcsb pdb:4REW|rcsb pdb:4ZHX|rcsb pdb:5EZV|rcsb pdb:5ISO|rcsb pdb:6B1U|rcsb pdb:6B2E|rcsb pdb:6C9F|rcsb pdb:6C9G|rcsb pdb:6C9H|rcsb pdb:6C9J|reactome:R-HSA-1445148|reactome:R-HSA-1632852|reactome:R-HSA-2151209|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6804756|refseq:XP_006719562.1|dip:DIP-39974N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/05 2017/08/10 rogid:HVA3rKbb8nS/97UCKVDCje0xTjw9606 rogid:JNBzPdCbcgr37RKb2sk6yVL+7649606 rigid:EOPYtLZl0o42VwQOZ/+0atzSWAQ false ha tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8TF40-1 uniprotkb:Q8NFG4-1 intact:EBI-15604805|ensembl:ENSP00000421985 intact:EBI-15604776|ensembl:ENSP00000285071 psi-mi:q8tf40-1(display_long)|uniprotkb:FNIP1(gene name)|psi-mi:FNIP1(display_short)|uniprotkb:KIAA1961(gene name synonym) psi-mi:q8nfg4-1(display_long)|uniprotkb:FLCN(gene name)|psi-mi:FLCN(display_short)|uniprotkb:BHD(gene name synonym)|uniprotkb:BHD skin lesion fibrofolliculoma protein(gene name synonym)|uniprotkb:Birt-Hogg-Dube syndrome protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Baba et al. (2006) pubmed:17028174|doi:10.1073/pnas.0603781103|imex:IM-23935 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15604911|imex:IM-23935-6|dip:DIP-198135E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000217128(gene)|ensembl:ENST00000510461(transcript)|intact:EBI-2946919(isoform-parent) ensembl:ENSG00000154803(gene)|ensembl:ENST00000285071(transcript)|intact:EBI-2970160(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/05 2017/08/10 rogid:HVA3rKbb8nS/97UCKVDCje0xTjw9606 rogid:gd59RCSQ6ssRdb2wz+HZl1V5wLY9606 rigid:KDK0P8FvrPnUmLfhRaZlkiRpqCk false flag tag:?-? ha tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q8NFG4-1 uniprotkb:P54619 intact:EBI-15604776|ensembl:ENSP00000285071 intact:EBI-1181439|ensembl:ENSP00000447433|uniprotkb:B4DDT7|uniprotkb:Q8N7V9 psi-mi:q8nfg4-1(display_long)|uniprotkb:FLCN(gene name)|psi-mi:FLCN(display_short)|uniprotkb:BHD(gene name synonym)|uniprotkb:BHD skin lesion fibrofolliculoma protein(gene name synonym)|uniprotkb:Birt-Hogg-Dube syndrome protein(gene name synonym) psi-mi:aakg1_human(display_long)|uniprotkb:PRKAG1(gene name)|psi-mi:PRKAG1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Baba et al. (2006) pubmed:17028174|doi:10.1073/pnas.0603781103|imex:IM-23935 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15604975|imex:IM-23935-9|dip:DIP-198136E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000154803(gene)|ensembl:ENST00000285071(transcript)|intact:EBI-2970160(isoform-parent) refseq:NP_001193638.1|refseq:NP_001193639.1|refseq:NP_002724.1|refseq:XP_011536864.1|reactome:R-HSA-9619483|reactome:R-HSA-9613354|ensembl:ENSG00000181929(gene)|ensembl:ENST00000548065(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004691"(cAMP-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006110"(regulation of glycolytic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008603"(cAMP-dependent protein kinase regulator activity)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016208"(AMP binding)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043531"(ADP binding)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051170"(import into nucleus)|go:"GO:0071900"(regulation of protein serine/threonine kinase activity)|interpro:IPR000644(Cystathionine beta-synthase, core)|interpro:IPR039166|mint:P54619|rcsb pdb:2UV4|rcsb pdb:2UV5|rcsb pdb:2UV6|rcsb pdb:2UV7|rcsb pdb:4CFE|rcsb pdb:4CFF|rcsb pdb:4RER|rcsb pdb:4REW|rcsb pdb:4ZHX|rcsb pdb:5EZV|rcsb pdb:5ISO|rcsb pdb:6B1U|rcsb pdb:6B2E|rcsb pdb:6C9F|rcsb pdb:6C9G|rcsb pdb:6C9H|rcsb pdb:6C9J|reactome:R-HSA-1445148|reactome:R-HSA-1632852|reactome:R-HSA-2151209|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6804756|refseq:XP_006719562.1|dip:DIP-39974N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/05 2017/08/10 rogid:gd59RCSQ6ssRdb2wz+HZl1V5wLY9606 rogid:JNBzPdCbcgr37RKb2sk6yVL+7649606 rigid:EOPYtLZl0o42VwQOZ/+0atzSWAQ false ha tag:?-? - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q8NFG4-1 uniprotkb:Q8TF40-1 intact:EBI-15604776|ensembl:ENSP00000285071 intact:EBI-15604805|ensembl:ENSP00000421985 psi-mi:q8nfg4-1(display_long)|uniprotkb:FLCN(gene name)|psi-mi:FLCN(display_short)|uniprotkb:BHD(gene name synonym)|uniprotkb:BHD skin lesion fibrofolliculoma protein(gene name synonym)|uniprotkb:Birt-Hogg-Dube syndrome protein(gene name synonym) psi-mi:q8tf40-1(display_long)|uniprotkb:FNIP1(gene name)|psi-mi:FNIP1(display_short)|uniprotkb:KIAA1961(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Baba et al. (2006) pubmed:17028174|doi:10.1073/pnas.0603781103|imex:IM-23935 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15604975|imex:IM-23935-9|dip:DIP-198136E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000154803(gene)|ensembl:ENST00000285071(transcript)|intact:EBI-2970160(isoform-parent) ensembl:ENSG00000217128(gene)|ensembl:ENST00000510461(transcript)|intact:EBI-2946919(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/05 2017/08/10 rogid:gd59RCSQ6ssRdb2wz+HZl1V5wLY9606 rogid:HVA3rKbb8nS/97UCKVDCje0xTjw9606 rigid:EOPYtLZl0o42VwQOZ/+0atzSWAQ false ha tag:?-? flag tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q8NFG4-1 uniprotkb:Q8TF40-1 intact:EBI-15604776|ensembl:ENSP00000285071 intact:EBI-15604805|ensembl:ENSP00000421985 psi-mi:q8nfg4-1(display_long)|uniprotkb:FLCN(gene name)|psi-mi:FLCN(display_short)|uniprotkb:BHD(gene name synonym)|uniprotkb:BHD skin lesion fibrofolliculoma protein(gene name synonym)|uniprotkb:Birt-Hogg-Dube syndrome protein(gene name synonym) psi-mi:q8tf40-1(display_long)|uniprotkb:FNIP1(gene name)|psi-mi:FNIP1(display_short)|uniprotkb:KIAA1961(gene name synonym) psi-mi:"MI:0096"(pull down) Baba et al. (2006) pubmed:17028174|doi:10.1073/pnas.0603781103|imex:IM-23935 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15604859|imex:IM-23935-4|dip:DIP-198135E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000154803(gene)|ensembl:ENST00000285071(transcript)|intact:EBI-2970160(isoform-parent) ensembl:ENSG00000217128(gene)|ensembl:ENST00000510461(transcript)|intact:EBI-2946919(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:gd59RCSQ6ssRdb2wz+HZl1V5wLY9606 rogid:HVA3rKbb8nS/97UCKVDCje0xTjw9606 rigid:KDK0P8FvrPnUmLfhRaZlkiRpqCk false sufficient binding region:345-579|glutathione s tranferase tag:?-? 35s radiolabel:?-? - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8NFG4-1 uniprotkb:Q8TF40-1 intact:EBI-15604776|ensembl:ENSP00000285071 intact:EBI-15604805|ensembl:ENSP00000421985 psi-mi:q8nfg4-1(display_long)|uniprotkb:FLCN(gene name)|psi-mi:FLCN(display_short)|uniprotkb:BHD(gene name synonym)|uniprotkb:BHD skin lesion fibrofolliculoma protein(gene name synonym)|uniprotkb:Birt-Hogg-Dube syndrome protein(gene name synonym) psi-mi:q8tf40-1(display_long)|uniprotkb:FNIP1(gene name)|psi-mi:FNIP1(display_short)|uniprotkb:KIAA1961(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Baba et al. (2006) pubmed:17028174|doi:10.1073/pnas.0603781103|imex:IM-23935 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15604884|imex:IM-23935-5|dip:DIP-198135E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000154803(gene)|ensembl:ENST00000285071(transcript)|intact:EBI-2970160(isoform-parent) ensembl:ENSG00000217128(gene)|ensembl:ENST00000510461(transcript)|intact:EBI-2946919(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/05 2017/08/10 rogid:gd59RCSQ6ssRdb2wz+HZl1V5wLY9606 rogid:HVA3rKbb8nS/97UCKVDCje0xTjw9606 rigid:KDK0P8FvrPnUmLfhRaZlkiRpqCk false sufficient binding region:345-579|flag tag:?-? ha tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q8TF40 uniprotkb:Q8NFG4 intact:EBI-2946919|ensembl:ENSP00000421985|uniprotkb:Q9BUT0|uniprotkb:Q86T47|uniprotkb:D6RJH5 intact:EBI-2970160|ensembl:ENSP00000285071|uniprotkb:Q96BD2|uniprotkb:Q96BE4|uniprotkb:A6NJJ8|uniprotkb:Q6ZRX1 psi-mi:fnip1_human(display_long)|uniprotkb:FNIP1(gene name)|psi-mi:FNIP1(display_short)|uniprotkb:KIAA1961(gene name synonym) psi-mi:flcn_human(display_long)|uniprotkb:FLCN(gene name)|psi-mi:FLCN(display_short)|uniprotkb:BHD(gene name synonym)|uniprotkb:BHD skin lesion fibrofolliculoma protein(gene name synonym)|uniprotkb:Birt-Hogg-Dube syndrome protein(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Baba et al. (2006) pubmed:17028174|doi:10.1073/pnas.0603781103|imex:IM-23935 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15605001|imex:IM-23935-10|dip:DIP-198135E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000217128(gene)|ensembl:ENST00000510461(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002327"(immature B cell differentiation)|go:"GO:0002904"(positive regulation of B cell apoptotic process)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0019899"(enzyme binding)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031929"(TOR signaling)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0051087"(chaperone binding)|go:"GO:2000973"(regulation of pro-B cell differentiation)|interpro:IPR026156|interpro:IPR028084|interpro:IPR028085|interpro:IPR028086|interpro:IPR037545|mint:Q8TF40|reactome:R-HSA-9639288|go:"GO:0032008"(positive regulation of TOR signaling)|refseq:NP_001008738.2|refseq:NP_588613.2|refseq:NP_001333042.1|dip:DIP-57169N go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010823"(negative regulation of mitochondrion organization)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031929"(TOR signaling)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035065"(regulation of histone acetylation)|go:"GO:0005737"(cytoplasm)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046578"(regulation of Ras protein signal transduction)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0072686"(mitotic spindle)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:1901723"(negative regulation of cell proliferation involved in kidney development)|go:"GO:1903444"(negative regulation of brown fat cell differentiation)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:2000973"(regulation of pro-B cell differentiation)|go:"GO:2001170"(negative regulation of ATP biosynthetic process)|interpro:IPR021713|interpro:IPR032035|interpro:IPR037520|interpro:IPR037521|interpro:IPR044886|rcsb pdb:3V42|rcsb pdb:6NZD|rcsb pdb:6ULG|reactome:R-HSA-9639288|ensembl:ENSG00000154803(gene)|ensembl:ENST00000285071(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|refseq:NP_653207.1|refseq:NP_659434.2|refseq:XP_016879795.1|refseq:XP_016879796.1|refseq:XP_016879797.1|dip:DIP-61287N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/05 2017/08/10 rogid:HVA3rKbb8nS/97UCKVDCje0xTjw9606 rogid:gd59RCSQ6ssRdb2wz+HZl1V5wLY9606 rigid:KDK0P8FvrPnUmLfhRaZlkiRpqCk false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8NFG4-1 uniprotkb:Q8TF40-1 intact:EBI-15604776|ensembl:ENSP00000285071 intact:EBI-15604805|ensembl:ENSP00000421985 psi-mi:q8nfg4-1(display_long)|uniprotkb:FLCN(gene name)|psi-mi:FLCN(display_short)|uniprotkb:BHD(gene name synonym)|uniprotkb:BHD skin lesion fibrofolliculoma protein(gene name synonym)|uniprotkb:Birt-Hogg-Dube syndrome protein(gene name synonym) psi-mi:q8tf40-1(display_long)|uniprotkb:FNIP1(gene name)|psi-mi:FNIP1(display_short)|uniprotkb:KIAA1961(gene name synonym) psi-mi:"MI:0096"(pull down) Baba et al. (2006) pubmed:17028174|doi:10.1073/pnas.0603781103|imex:IM-23935 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15605018|imex:IM-23935-11|dip:DIP-198135E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000154803(gene)|ensembl:ENST00000285071(transcript)|intact:EBI-2970160(isoform-parent) ensembl:ENSG00000217128(gene)|ensembl:ENST00000510461(transcript)|intact:EBI-2946919(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:gd59RCSQ6ssRdb2wz+HZl1V5wLY9606 rogid:HVA3rKbb8nS/97UCKVDCje0xTjw9606 rigid:KDK0P8FvrPnUmLfhRaZlkiRpqCk false 35s radiolabel:?-? sufficient binding region:300-1166|glutathione s tranferase tag:?-? - - psi-mi:"MI:0833"(autoradiography) psi-mi:"MI:0833"(autoradiography)