#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q6EZC2 uniprotkb:Q0VCX2 intact:EBI-15604275 intact:EBI-5282091|uniprotkb:A7E3V5|ensembl:ENSBTAP00000052422 psi-mi:suba_ecolx(display_long)|uniprotkb:subA(gene name)|psi-mi:subA(display_short) psi-mi:bip_bovin(display_long)|uniprotkb:HSPA5(gene name)|psi-mi:HSPA5(display_short)|uniprotkb:GRP78(gene name synonym)|uniprotkb:78 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Binding-immunoglobulin protein(gene name synonym)|uniprotkb:Heat shock protein 70 family protein 5(gene name synonym)|uniprotkb:Heat shock protein family A member 5(gene name synonym)|uniprotkb:Immunoglobulin heavy chain-binding protein(gene name synonym) psi-mi:"MI:0435"(protease assay) Paton et al. (2006) pubmed:17024087|doi:10.1038/nature05124|imex:IM-21447 taxid:562(ecolx)|taxid:562(Escherichia coli) taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") psi-mi:"MI:0570"(protein cleavage) psi-mi:"MI:0465"(DIP) intact:EBI-15604285|imex:IM-21447-1|dip:DIP-191605E - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0044164"(host cell cytosol)|go:"GO:0044166"(host cell endoplasmic reticulum lumen)|go:"GO:0090729"(toxin activity)|interpro:IPR000209(Peptidase S8 and S53, subtilisin, kexin, sedolisin)|interpro:IPR036852|rcsb pdb:2IY9|rcsb pdb:4BWG|dip:DIP-60412N refseq:NP_001068616.1|dip:DIP-60411N|ensembl:ENSBTAG00000007662(gene)|ensembl:ENSBTAT00000057533(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006983"(ER overload response)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021589"(cerebellum structural organization)|go:"GO:0021680"(cerebellar Purkinje cell layer development)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0035437"(maintenance of protein localization in endoplasmic reticulum)|go:"GO:0042026"(protein refolding)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043022"(ribosome binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1901998"(toxin transport)|go:"GO:1903895"(negative regulation of IRE1-mediated unfolded protein response)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR042050|interpro:IPR043129 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:9wEBmd6NQNnb8Wve6ZWBaNW8DPc562 rogid:LKgBPad+Kw9U8slUc2ZwEw1aTL49913 rigid:daw0K7vz8v3A0vhaJALS54txOm4 false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)