#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P27930	uniprotkb:P01583	intact:EBI-2831568|uniprotkb:Q9UE68|uniprotkb:D3DVJ5|ensembl:ENSP00000330959|ensembl:ENSP00000377066|uniprotkb:Q6LCE6	intact:EBI-1749782|uniprotkb:Q7RU02|ensembl:ENSP00000263339|uniprotkb:Q53QF9	psi-mi:il1r2_human(display_long)|uniprotkb:IL1R2(gene name)|psi-mi:IL1R2(display_short)|uniprotkb:IL1RB(gene name synonym)|uniprotkb:CD121 antigen-like family member B(gene name synonym)|uniprotkb:CDw121b(gene name synonym)|uniprotkb:Interleukin-1 receptor beta(gene name synonym)|uniprotkb:Interleukin-1 receptor type II(gene name synonym)|uniprotkb:IL-1 type II receptor(gene name synonym)	psi-mi:il1a_human(display_long)|uniprotkb:IL1A(gene name)|psi-mi:IL1A(display_short)|uniprotkb:IL1F1(gene name synonym)|uniprotkb:Hematopoietin-1(gene name synonym)	psi-mi:"MI:0655"(lambda repressor two hybrid)	Kawaguchi et al. (2006)	pubmed:16971486|doi:10.1073/pnas.0603545103|imex:IM-23910	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15600708|imex:IM-23910-1|dip:DIP-198070E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011510106.1|ensembl:ENST00000332549(transcript)|ensembl:ENST00000393414(transcript)|go:"GO:0004908"(interleukin-1 receptor activity)|go:"GO:0004910"(interleukin-1, type II, blocking receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019966"(interleukin-1 binding)|go:"GO:0032690"(negative regulation of interleukin-1 alpha production)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:2000660"(negative regulation of interleukin-1-mediated signaling pathway)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR004074(Interleukin-1 receptor, type I and type II)|interpro:IPR004077(Interleukin-1 receptor, type II)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013151(Immunoglobulin)|ensembl:ENSG00000115590(gene)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015621(Interleukin-1 receptor)|interpro:IPR036179|interpro:IPR041416|rcsb pdb:3O4O|reactome:R-HSA-6783783|reactome:R-HSA-9020702|refseq:NP_004624.1|refseq:NP_001248348.1|refseq:XP_006712797.1|dip:DIP-61267N	dip:DIP-40550N|ensembl:ENSG00000115008(gene)|ensembl:ENST00000263339(transcript)|go:"GO:0001660"(fever generation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002248"(connective tissue replacement involved in inflammatory response wound healing)|refseq:NP_000566.3|go:"GO:0005125"(cytokine activity)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033092"(positive regulation of immature T cell proliferation in thymus)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035234"(ectopic germ cell programmed cell death)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046688"(response to copper ion)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000975(Interleukin-1)|interpro:IPR003295(Interleukin-1, alpha IL1A)|interpro:IPR003502(Interleukin-1 propeptide)|interpro:IPR008996(Cytokine, IL-1-like)|interpro:IPR020877|rcsb pdb:1ITA|rcsb pdb:2ILA|rcsb pdb:2KKI|rcsb pdb:2L5X|rcsb pdb:5UC6|reactome:R-HSA-2559582|reactome:R-HSA-448706|reactome:R-HSA-5620971|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-9020702|reactome:R-HSA-9660826|go:"GO:0005507"(copper ion binding)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/05	2017/08/10	rogid:dbXLqsJM7HjQKDnuuUlyGcwp/Tc9606	rogid:y8/XvXINmqNymbshZLH1Y1CyUOM9606	rigid:eWfPBxPD23qUuKoInqjzEGo8AAQ	false	-	sufficient binding region:113-271	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O00165	uniprotkb:P01583	intact:EBI-357001|uniprotkb:A8W4W9|uniprotkb:A8W4X0|uniprotkb:B4DUJ7|uniprotkb:Q5VYD7|uniprotkb:Q5VYD5|uniprotkb:Q96AU4|uniprotkb:Q9BS80|ensembl:ENSP00000329002	intact:EBI-1749782|uniprotkb:Q7RU02|ensembl:ENSP00000263339|uniprotkb:Q53QF9	psi-mi:hax1_human(display_long)|uniprotkb:HAX1(gene name)|psi-mi:HAX1(display_short)|uniprotkb:HS1BP1(gene name synonym)|uniprotkb:HS1-associating protein X-1(gene name synonym)|uniprotkb:HS1-binding protein 1(gene name synonym)	psi-mi:il1a_human(display_long)|uniprotkb:IL1A(gene name)|psi-mi:IL1A(display_short)|uniprotkb:IL1F1(gene name synonym)|uniprotkb:Hematopoietin-1(gene name synonym)	psi-mi:"MI:0655"(lambda repressor two hybrid)	Kawaguchi et al. (2006)	pubmed:16971486|doi:10.1073/pnas.0603545103|imex:IM-23910	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15600748|imex:IM-23910-3|dip:DIP-198072E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001018238.1|refseq:NP_006109.2|dip:DIP-36771N|ensembl:ENSG00000143575(gene)|ensembl:ENST00000328703(transcript)|go:"GO:0000932"(P-body)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005938"(cell cortex)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019966"(interleukin-1 binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR017248(HS1-associating, X-1)|mint:O00165	dip:DIP-40550N|ensembl:ENSG00000115008(gene)|ensembl:ENST00000263339(transcript)|go:"GO:0001660"(fever generation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002248"(connective tissue replacement involved in inflammatory response wound healing)|refseq:NP_000566.3|go:"GO:0005125"(cytokine activity)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033092"(positive regulation of immature T cell proliferation in thymus)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035234"(ectopic germ cell programmed cell death)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046688"(response to copper ion)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000975(Interleukin-1)|interpro:IPR003295(Interleukin-1, alpha IL1A)|interpro:IPR003502(Interleukin-1 propeptide)|interpro:IPR008996(Cytokine, IL-1-like)|interpro:IPR020877|rcsb pdb:1ITA|rcsb pdb:2ILA|rcsb pdb:2KKI|rcsb pdb:2L5X|rcsb pdb:5UC6|reactome:R-HSA-2559582|reactome:R-HSA-448706|reactome:R-HSA-5620971|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-9020702|reactome:R-HSA-9660826|go:"GO:0005507"(copper ion binding)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/05	2017/08/10	rogid:XRyEPYge2cQFiWdmOaiNIAxd1yQ9606	rogid:y8/XvXINmqNymbshZLH1Y1CyUOM9606	rigid:pJkyUYlrGoIO0pVfprv0KOp2krs	false	-	sufficient binding region:113-271|sufficient binding region:1-112	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P27930	uniprotkb:P01583	intact:EBI-2831568|uniprotkb:Q9UE68|uniprotkb:D3DVJ5|ensembl:ENSP00000330959|ensembl:ENSP00000377066|uniprotkb:Q6LCE6	intact:EBI-1749782|uniprotkb:Q7RU02|ensembl:ENSP00000263339|uniprotkb:Q53QF9	psi-mi:il1r2_human(display_long)|uniprotkb:IL1R2(gene name)|psi-mi:IL1R2(display_short)|uniprotkb:IL1RB(gene name synonym)|uniprotkb:CD121 antigen-like family member B(gene name synonym)|uniprotkb:CDw121b(gene name synonym)|uniprotkb:Interleukin-1 receptor beta(gene name synonym)|uniprotkb:Interleukin-1 receptor type II(gene name synonym)|uniprotkb:IL-1 type II receptor(gene name synonym)	psi-mi:il1a_human(display_long)|uniprotkb:IL1A(gene name)|psi-mi:IL1A(display_short)|uniprotkb:IL1F1(gene name synonym)|uniprotkb:Hematopoietin-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kawaguchi et al. (2006)	pubmed:16971486|doi:10.1073/pnas.0603545103|imex:IM-23910	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15600727|imex:IM-23910-2|dip:DIP-198070E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011510106.1|ensembl:ENST00000332549(transcript)|ensembl:ENST00000393414(transcript)|go:"GO:0004908"(interleukin-1 receptor activity)|go:"GO:0004910"(interleukin-1, type II, blocking receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019966"(interleukin-1 binding)|go:"GO:0032690"(negative regulation of interleukin-1 alpha production)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:2000660"(negative regulation of interleukin-1-mediated signaling pathway)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR004074(Interleukin-1 receptor, type I and type II)|interpro:IPR004077(Interleukin-1 receptor, type II)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013151(Immunoglobulin)|ensembl:ENSG00000115590(gene)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015621(Interleukin-1 receptor)|interpro:IPR036179|interpro:IPR041416|rcsb pdb:3O4O|reactome:R-HSA-6783783|reactome:R-HSA-9020702|refseq:NP_004624.1|refseq:NP_001248348.1|refseq:XP_006712797.1|dip:DIP-61267N	dip:DIP-40550N|ensembl:ENSG00000115008(gene)|ensembl:ENST00000263339(transcript)|go:"GO:0001660"(fever generation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002248"(connective tissue replacement involved in inflammatory response wound healing)|refseq:NP_000566.3|go:"GO:0005125"(cytokine activity)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033092"(positive regulation of immature T cell proliferation in thymus)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035234"(ectopic germ cell programmed cell death)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046688"(response to copper ion)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000975(Interleukin-1)|interpro:IPR003295(Interleukin-1, alpha IL1A)|interpro:IPR003502(Interleukin-1 propeptide)|interpro:IPR008996(Cytokine, IL-1-like)|interpro:IPR020877|rcsb pdb:1ITA|rcsb pdb:2ILA|rcsb pdb:2KKI|rcsb pdb:2L5X|rcsb pdb:5UC6|reactome:R-HSA-2559582|reactome:R-HSA-448706|reactome:R-HSA-5620971|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-9020702|reactome:R-HSA-9660826|go:"GO:0005507"(copper ion binding)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/05	2017/08/10	rogid:dbXLqsJM7HjQKDnuuUlyGcwp/Tc9606	rogid:y8/XvXINmqNymbshZLH1Y1CyUOM9606	rigid:eWfPBxPD23qUuKoInqjzEGo8AAQ	false	-	sufficient binding region:113-271|v5 tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01583	uniprotkb:O00165	intact:EBI-1749782|uniprotkb:Q7RU02|ensembl:ENSP00000263339|uniprotkb:Q53QF9	intact:EBI-357001|uniprotkb:A8W4W9|uniprotkb:A8W4X0|uniprotkb:B4DUJ7|uniprotkb:Q5VYD7|uniprotkb:Q5VYD5|uniprotkb:Q96AU4|uniprotkb:Q9BS80|ensembl:ENSP00000329002	psi-mi:il1a_human(display_long)|uniprotkb:IL1A(gene name)|psi-mi:IL1A(display_short)|uniprotkb:IL1F1(gene name synonym)|uniprotkb:Hematopoietin-1(gene name synonym)	psi-mi:hax1_human(display_long)|uniprotkb:HAX1(gene name)|psi-mi:HAX1(display_short)|uniprotkb:HS1BP1(gene name synonym)|uniprotkb:HS1-associating protein X-1(gene name synonym)|uniprotkb:HS1-binding protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kawaguchi et al. (2006)	pubmed:16971486|doi:10.1073/pnas.0603545103|imex:IM-23910	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15600769|imex:IM-23910-4|dip:DIP-198071E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-40550N|ensembl:ENSG00000115008(gene)|ensembl:ENST00000263339(transcript)|go:"GO:0001660"(fever generation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002248"(connective tissue replacement involved in inflammatory response wound healing)|refseq:NP_000566.3|go:"GO:0005125"(cytokine activity)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033092"(positive regulation of immature T cell proliferation in thymus)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035234"(ectopic germ cell programmed cell death)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046688"(response to copper ion)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000975(Interleukin-1)|interpro:IPR003295(Interleukin-1, alpha IL1A)|interpro:IPR003502(Interleukin-1 propeptide)|interpro:IPR008996(Cytokine, IL-1-like)|interpro:IPR020877|rcsb pdb:1ITA|rcsb pdb:2ILA|rcsb pdb:2KKI|rcsb pdb:2L5X|rcsb pdb:5UC6|reactome:R-HSA-2559582|reactome:R-HSA-448706|reactome:R-HSA-5620971|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-9020702|reactome:R-HSA-9660826|go:"GO:0005507"(copper ion binding)	refseq:NP_001018238.1|refseq:NP_006109.2|dip:DIP-36771N|ensembl:ENSG00000143575(gene)|ensembl:ENST00000328703(transcript)|go:"GO:0000932"(P-body)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005938"(cell cortex)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019966"(interleukin-1 binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR017248(HS1-associating, X-1)|mint:O00165	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/05	2017/08/10	rogid:y8/XvXINmqNymbshZLH1Y1CyUOM9606	rogid:XRyEPYge2cQFiWdmOaiNIAxd1yQ9606	rigid:L67xZX+WQUNVxcjhnVc/1m63C+U	false	-	-	-	-	psi-mi:"MI:0039"(edman degradation)	psi-mi:"MI:0039"(edman degradation)
uniprotkb:P01583	uniprotkb:P27930	intact:EBI-1749782|uniprotkb:Q7RU02|ensembl:ENSP00000263339|uniprotkb:Q53QF9	intact:EBI-2831568|uniprotkb:Q9UE68|uniprotkb:D3DVJ5|ensembl:ENSP00000330959|ensembl:ENSP00000377066|uniprotkb:Q6LCE6	psi-mi:il1a_human(display_long)|uniprotkb:IL1A(gene name)|psi-mi:IL1A(display_short)|uniprotkb:IL1F1(gene name synonym)|uniprotkb:Hematopoietin-1(gene name synonym)	psi-mi:il1r2_human(display_long)|uniprotkb:IL1R2(gene name)|psi-mi:IL1R2(display_short)|uniprotkb:IL1RB(gene name synonym)|uniprotkb:CD121 antigen-like family member B(gene name synonym)|uniprotkb:CDw121b(gene name synonym)|uniprotkb:Interleukin-1 receptor beta(gene name synonym)|uniprotkb:Interleukin-1 receptor type II(gene name synonym)|uniprotkb:IL-1 type II receptor(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kawaguchi et al. (2006)	pubmed:16971486|doi:10.1073/pnas.0603545103|imex:IM-23910	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15600769|imex:IM-23910-4|dip:DIP-198071E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-40550N|ensembl:ENSG00000115008(gene)|ensembl:ENST00000263339(transcript)|go:"GO:0001660"(fever generation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002248"(connective tissue replacement involved in inflammatory response wound healing)|refseq:NP_000566.3|go:"GO:0005125"(cytokine activity)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033092"(positive regulation of immature T cell proliferation in thymus)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035234"(ectopic germ cell programmed cell death)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046688"(response to copper ion)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000975(Interleukin-1)|interpro:IPR003295(Interleukin-1, alpha IL1A)|interpro:IPR003502(Interleukin-1 propeptide)|interpro:IPR008996(Cytokine, IL-1-like)|interpro:IPR020877|rcsb pdb:1ITA|rcsb pdb:2ILA|rcsb pdb:2KKI|rcsb pdb:2L5X|rcsb pdb:5UC6|reactome:R-HSA-2559582|reactome:R-HSA-448706|reactome:R-HSA-5620971|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-9020702|reactome:R-HSA-9660826|go:"GO:0005507"(copper ion binding)	refseq:XP_011510106.1|ensembl:ENST00000332549(transcript)|ensembl:ENST00000393414(transcript)|go:"GO:0004908"(interleukin-1 receptor activity)|go:"GO:0004910"(interleukin-1, type II, blocking receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019966"(interleukin-1 binding)|go:"GO:0032690"(negative regulation of interleukin-1 alpha production)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:2000660"(negative regulation of interleukin-1-mediated signaling pathway)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR004074(Interleukin-1 receptor, type I and type II)|interpro:IPR004077(Interleukin-1 receptor, type II)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013151(Immunoglobulin)|ensembl:ENSG00000115590(gene)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015621(Interleukin-1 receptor)|interpro:IPR036179|interpro:IPR041416|rcsb pdb:3O4O|reactome:R-HSA-6783783|reactome:R-HSA-9020702|refseq:NP_004624.1|refseq:NP_001248348.1|refseq:XP_006712797.1|dip:DIP-61267N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/05	2017/08/10	rogid:y8/XvXINmqNymbshZLH1Y1CyUOM9606	rogid:dbXLqsJM7HjQKDnuuUlyGcwp/Tc9606	rigid:L67xZX+WQUNVxcjhnVc/1m63C+U	false	-	-	-	-	psi-mi:"MI:0039"(edman degradation)	psi-mi:"MI:0039"(edman degradation)