#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P42573	uniprotkb:P30429	intact:EBI-494247|uniprotkb:P45435|uniprotkb:Q9GQQ4|uniprotkb:Q9NAQ8|ensemblmetazoa:C48D1.2a.1	intact:EBI-494118|uniprotkb:Q5BHI5|ensemblmetazoa:C35D10.9b.1|ensemblmetazoa:C35D10.9b.2	psi-mi:ced3_caeel(display_long)|uniprotkb:ced-3(gene name)|psi-mi:ced-3(display_short)|uniprotkb:Caspase ced-3(gene name synonym)|uniprotkb:C48D1.2(orf name)	psi-mi:ced4_caeel(display_long)|uniprotkb:ced-4(gene name)|psi-mi:ced-4(display_short)|uniprotkb:C35D10.9(orf name)	psi-mi:"MI:0047"(far western blotting)	Tzur et al. (2006)	pubmed:16938876|doi:10.1073/pnas.0604224103|imex:IM-23896	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15599029|imex:IM-23896-1|dip:DIP-67E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001255708.1|wormbase:C48D1.2a|reactome:R-CEL-111465|reactome:R-CEL-198323|reactome:R-CEL-264870|reactome:R-CEL-448706|dip:DIP-244N|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030163"(protein catabolic process)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031965"(nuclear membrane)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0040028"(regulation of vulval development)|go:"GO:0040034"(regulation of development, heterochronic)|go:"GO:0042659"(regulation of cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0098793"(presynapse)|go:"GO:1901046"(positive regulation of oviposition)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1904747"(positive regulation of apoptotic process involved in development)|go:"GO:1905803"(negative regulation of cellular response to manganese ion)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:1905845"(positive regulation of cellular response to gamma radiation)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|rcsb pdb:4M9R|rcsb pdb:4M9S|rcsb pdb:4M9X|rcsb pdb:4M9Y|rcsb pdb:4M9Z|ensemblmetazoa:C48D1.2a.1(transcript)|ensemblmetazoa:WBGene00000417(gene)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0008303"(caspase complex)|reactome:R-CEL-140342|reactome:R-CEL-351906|reactome:R-CEL-418889	refseq:NP_001021202.1|refseq:NP_001021203.1|wormbase:C35D10.9a|wormbase:C35D10.9b|dip:DIP-1016N|ensemblmetazoa:C35D10.9b.1(transcript)|ensemblmetazoa:C35D10.9b.2(transcript)|ensemblmetazoa:WBGene00000418(gene)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0008303"(caspase complex)|go:"GO:0008361"(regulation of cell size)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0016020"(membrane)|go:"GO:0016505"(peptidase activator activity involved in apoptotic process)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040034"(regulation of development, heterochronic)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043531"(ADP binding)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051432"(BH1 domain binding)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0089720"(caspase binding)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1904747"(positive regulation of apoptotic process involved in development)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002182(NB-ARC)|interpro:IPR011029(DEATH-like)|interpro:IPR016854(Apoptosis regulator, Ced-4)|interpro:IPR027417|interpro:IPR036388|interpro:IPR036390|rcsb pdb:2A5Y|rcsb pdb:3LQQ|rcsb pdb:3LQR|rcsb pdb:4M9S|rcsb pdb:4M9X|rcsb pdb:4M9Y|rcsb pdb:4M9Z|go:"GO:0030155"(regulation of cell adhesion)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:HFfz1WjirXjAkC5PNlCcB2NqcKE6239	rogid:nrCvl4N8Vx6zKbAnnOseTjz1RmA6239	rigid:MV1ialotG+xu+GKbv7P/X0J/oAo	false	-	35s radiolabel:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q21443	uniprotkb:Q20924	intact:EBI-314110|uniprotkb:O62127|ensemblmetazoa:DY3.2.1|ensemblmetazoa:DY3.2.2	intact:EBI-15599048|ensemblmetazoa:F57B1.2.1	psi-mi:lmn1_caeel(display_long)|uniprotkb:lmn-1(gene name)|psi-mi:lmn-1(display_short)|uniprotkb:lam-1(gene name synonym)|uniprotkb:DY3.2(orf name)|uniprotkb:CeLam-1(gene name synonym)|uniprotkb:Ce-lamin(gene name synonym)	psi-mi:sun1_caeel(display_long)|uniprotkb:sun-1(gene name)|psi-mi:sun-1(display_short)|uniprotkb:mtf-1(gene name synonym)|uniprotkb:F57B1.2(orf name)	psi-mi:"MI:0096"(pull down)	Tzur et al. (2006)	pubmed:16938876|doi:10.1073/pnas.0604224103|imex:IM-23896	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15599068|imex:IM-23896-2|dip:DIP-198048E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-CEL-9013405|reactome:R-CEL-9035034|refseq:NP_492371.1|wormbase:DY3.2|ensemblmetazoa:DY3.2.1(transcript)|ensemblmetazoa:DY3.2.2(transcript)|ensemblmetazoa:WBGene00003052(gene)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005638"(lamin filament)|go:"GO:0006997"(nucleus organization)|go:"GO:0007281"(germ cell development)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008104"(protein localization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0030473"(nuclear migration along microtubule)|go:"GO:0034399"(nuclear periphery)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0051664"(nuclear pore localization)|go:"GO:0051983"(regulation of chromosome segregation)|interpro:IPR001322(Intermediate filament, C-terminal)|interpro:IPR036415|interpro:IPR039008|reactome:R-CEL-4419969|dip:DIP-29640N	interpro:IPR012919(Sad1/UNC-like, C-terminal)|ensemblmetazoa:F57B1.2.1(transcript)|ensemblmetazoa:WBGene00006311(gene)|go:"GO:0005635"(nuclear envelope)|go:"GO:0006998"(nuclear envelope organization)|go:"GO:0008104"(protein localization)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034993"(meiotic nuclear membrane microtubule tethering complex)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0051642"(centrosome localization)|refseq:NP_506281.1|wormbase:F57B1.2|dip:DIP-52612N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:LV8WvN7Tglcs/Qqc5u6RZNba9d46239	rogid:4vkFArdqG9dMhnv/rFeFR7JlmHE6239	rigid:cWHix47AQbi0gRP1bPx8TYmdxao	false	his tag:n-n	35s radiolabel:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q20924	uniprotkb:P30429	intact:EBI-15599048|ensemblmetazoa:F57B1.2.1	intact:EBI-494118|uniprotkb:Q5BHI5|ensemblmetazoa:C35D10.9b.1|ensemblmetazoa:C35D10.9b.2	psi-mi:sun1_caeel(display_long)|uniprotkb:sun-1(gene name)|psi-mi:sun-1(display_short)|uniprotkb:mtf-1(gene name synonym)|uniprotkb:F57B1.2(orf name)	psi-mi:ced4_caeel(display_long)|uniprotkb:ced-4(gene name)|psi-mi:ced-4(display_short)|uniprotkb:C35D10.9(orf name)	psi-mi:"MI:0096"(pull down)	Tzur et al. (2006)	pubmed:16938876|doi:10.1073/pnas.0604224103|imex:IM-23896	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15599089|imex:IM-23896-3|dip:DIP-198047E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012919(Sad1/UNC-like, C-terminal)|ensemblmetazoa:F57B1.2.1(transcript)|ensemblmetazoa:WBGene00006311(gene)|go:"GO:0005635"(nuclear envelope)|go:"GO:0006998"(nuclear envelope organization)|go:"GO:0008104"(protein localization)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034993"(meiotic nuclear membrane microtubule tethering complex)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0051642"(centrosome localization)|refseq:NP_506281.1|wormbase:F57B1.2|dip:DIP-52612N	refseq:NP_001021202.1|refseq:NP_001021203.1|wormbase:C35D10.9a|wormbase:C35D10.9b|dip:DIP-1016N|ensemblmetazoa:C35D10.9b.1(transcript)|ensemblmetazoa:C35D10.9b.2(transcript)|ensemblmetazoa:WBGene00000418(gene)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0008303"(caspase complex)|go:"GO:0008361"(regulation of cell size)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0016020"(membrane)|go:"GO:0016505"(peptidase activator activity involved in apoptotic process)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040034"(regulation of development, heterochronic)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043531"(ADP binding)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051432"(BH1 domain binding)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0089720"(caspase binding)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1904747"(positive regulation of apoptotic process involved in development)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002182(NB-ARC)|interpro:IPR011029(DEATH-like)|interpro:IPR016854(Apoptosis regulator, Ced-4)|interpro:IPR027417|interpro:IPR036388|interpro:IPR036390|rcsb pdb:2A5Y|rcsb pdb:3LQQ|rcsb pdb:3LQR|rcsb pdb:4M9S|rcsb pdb:4M9X|rcsb pdb:4M9Y|rcsb pdb:4M9Z|go:"GO:0030155"(regulation of cell adhesion)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:4vkFArdqG9dMhnv/rFeFR7JlmHE6239	rogid:nrCvl4N8Vx6zKbAnnOseTjz1RmA6239	rigid:o5uJgWVS9yCuY5VNIeEEL29lA4o	false	his tag:n-n	35s radiolabel:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q20924	uniprotkb:P30429	intact:EBI-15599048|ensemblmetazoa:F57B1.2.1	intact:EBI-494118|uniprotkb:Q5BHI5|ensemblmetazoa:C35D10.9b.1|ensemblmetazoa:C35D10.9b.2	psi-mi:sun1_caeel(display_long)|uniprotkb:sun-1(gene name)|psi-mi:sun-1(display_short)|uniprotkb:mtf-1(gene name synonym)|uniprotkb:F57B1.2(orf name)	psi-mi:ced4_caeel(display_long)|uniprotkb:ced-4(gene name)|psi-mi:ced-4(display_short)|uniprotkb:C35D10.9(orf name)	psi-mi:"MI:0047"(far western blotting)	Tzur et al. (2006)	pubmed:16938876|doi:10.1073/pnas.0604224103|imex:IM-23896	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15599110|imex:IM-23896-4|dip:DIP-198047E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012919(Sad1/UNC-like, C-terminal)|ensemblmetazoa:F57B1.2.1(transcript)|ensemblmetazoa:WBGene00006311(gene)|go:"GO:0005635"(nuclear envelope)|go:"GO:0006998"(nuclear envelope organization)|go:"GO:0008104"(protein localization)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034993"(meiotic nuclear membrane microtubule tethering complex)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0051642"(centrosome localization)|refseq:NP_506281.1|wormbase:F57B1.2|dip:DIP-52612N	refseq:NP_001021202.1|refseq:NP_001021203.1|wormbase:C35D10.9a|wormbase:C35D10.9b|dip:DIP-1016N|ensemblmetazoa:C35D10.9b.1(transcript)|ensemblmetazoa:C35D10.9b.2(transcript)|ensemblmetazoa:WBGene00000418(gene)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0008303"(caspase complex)|go:"GO:0008361"(regulation of cell size)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0016020"(membrane)|go:"GO:0016505"(peptidase activator activity involved in apoptotic process)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040034"(regulation of development, heterochronic)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043531"(ADP binding)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051432"(BH1 domain binding)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0089720"(caspase binding)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1904747"(positive regulation of apoptotic process involved in development)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002182(NB-ARC)|interpro:IPR011029(DEATH-like)|interpro:IPR016854(Apoptosis regulator, Ced-4)|interpro:IPR027417|interpro:IPR036388|interpro:IPR036390|rcsb pdb:2A5Y|rcsb pdb:3LQQ|rcsb pdb:3LQR|rcsb pdb:4M9S|rcsb pdb:4M9X|rcsb pdb:4M9Y|rcsb pdb:4M9Z|go:"GO:0030155"(regulation of cell adhesion)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:4vkFArdqG9dMhnv/rFeFR7JlmHE6239	rogid:nrCvl4N8Vx6zKbAnnOseTjz1RmA6239	rigid:o5uJgWVS9yCuY5VNIeEEL29lA4o	false	-	35s radiolabel:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q20924	uniprotkb:P30429	intact:EBI-15599048|ensemblmetazoa:F57B1.2.1	intact:EBI-494118|uniprotkb:Q5BHI5|ensemblmetazoa:C35D10.9b.1|ensemblmetazoa:C35D10.9b.2	psi-mi:sun1_caeel(display_long)|uniprotkb:sun-1(gene name)|psi-mi:sun-1(display_short)|uniprotkb:mtf-1(gene name synonym)|uniprotkb:F57B1.2(orf name)	psi-mi:ced4_caeel(display_long)|uniprotkb:ced-4(gene name)|psi-mi:ced-4(display_short)|uniprotkb:C35D10.9(orf name)	psi-mi:"MI:0096"(pull down)	Tzur et al. (2006)	pubmed:16938876|doi:10.1073/pnas.0604224103|imex:IM-23896	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15599129|imex:IM-23896-5|dip:DIP-198047E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012919(Sad1/UNC-like, C-terminal)|ensemblmetazoa:F57B1.2.1(transcript)|ensemblmetazoa:WBGene00006311(gene)|go:"GO:0005635"(nuclear envelope)|go:"GO:0006998"(nuclear envelope organization)|go:"GO:0008104"(protein localization)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034993"(meiotic nuclear membrane microtubule tethering complex)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0051642"(centrosome localization)|refseq:NP_506281.1|wormbase:F57B1.2|dip:DIP-52612N	refseq:NP_001021202.1|refseq:NP_001021203.1|wormbase:C35D10.9a|wormbase:C35D10.9b|dip:DIP-1016N|ensemblmetazoa:C35D10.9b.1(transcript)|ensemblmetazoa:C35D10.9b.2(transcript)|ensemblmetazoa:WBGene00000418(gene)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0008303"(caspase complex)|go:"GO:0008361"(regulation of cell size)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0016020"(membrane)|go:"GO:0016505"(peptidase activator activity involved in apoptotic process)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040034"(regulation of development, heterochronic)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043531"(ADP binding)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051432"(BH1 domain binding)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0089720"(caspase binding)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1904747"(positive regulation of apoptotic process involved in development)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002182(NB-ARC)|interpro:IPR011029(DEATH-like)|interpro:IPR016854(Apoptosis regulator, Ced-4)|interpro:IPR027417|interpro:IPR036388|interpro:IPR036390|rcsb pdb:2A5Y|rcsb pdb:3LQQ|rcsb pdb:3LQR|rcsb pdb:4M9S|rcsb pdb:4M9X|rcsb pdb:4M9Y|rcsb pdb:4M9Z|go:"GO:0030155"(regulation of cell adhesion)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:4vkFArdqG9dMhnv/rFeFR7JlmHE6239	rogid:nrCvl4N8Vx6zKbAnnOseTjz1RmA6239	rigid:o5uJgWVS9yCuY5VNIeEEL29lA4o	false	35s radiolabel:?-?	his tag:n-n	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:P42573	uniprotkb:P30429	intact:EBI-494247|uniprotkb:P45435|uniprotkb:Q9GQQ4|uniprotkb:Q9NAQ8|ensemblmetazoa:C48D1.2a.1	intact:EBI-494118|uniprotkb:Q5BHI5|ensemblmetazoa:C35D10.9b.1|ensemblmetazoa:C35D10.9b.2	psi-mi:ced3_caeel(display_long)|uniprotkb:ced-3(gene name)|psi-mi:ced-3(display_short)|uniprotkb:Caspase ced-3(gene name synonym)|uniprotkb:C48D1.2(orf name)	psi-mi:ced4_caeel(display_long)|uniprotkb:ced-4(gene name)|psi-mi:ced-4(display_short)|uniprotkb:C35D10.9(orf name)	psi-mi:"MI:0096"(pull down)	Tzur et al. (2006)	pubmed:16938876|doi:10.1073/pnas.0604224103|imex:IM-23896	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15599150|imex:IM-23896-6|dip:DIP-67E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001255708.1|wormbase:C48D1.2a|reactome:R-CEL-111465|reactome:R-CEL-198323|reactome:R-CEL-264870|reactome:R-CEL-448706|dip:DIP-244N|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030163"(protein catabolic process)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031965"(nuclear membrane)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0040028"(regulation of vulval development)|go:"GO:0040034"(regulation of development, heterochronic)|go:"GO:0042659"(regulation of cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0098793"(presynapse)|go:"GO:1901046"(positive regulation of oviposition)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1904747"(positive regulation of apoptotic process involved in development)|go:"GO:1905803"(negative regulation of cellular response to manganese ion)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:1905845"(positive regulation of cellular response to gamma radiation)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|rcsb pdb:4M9R|rcsb pdb:4M9S|rcsb pdb:4M9X|rcsb pdb:4M9Y|rcsb pdb:4M9Z|ensemblmetazoa:C48D1.2a.1(transcript)|ensemblmetazoa:WBGene00000417(gene)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0008303"(caspase complex)|reactome:R-CEL-140342|reactome:R-CEL-351906|reactome:R-CEL-418889	refseq:NP_001021202.1|refseq:NP_001021203.1|wormbase:C35D10.9a|wormbase:C35D10.9b|dip:DIP-1016N|ensemblmetazoa:C35D10.9b.1(transcript)|ensemblmetazoa:C35D10.9b.2(transcript)|ensemblmetazoa:WBGene00000418(gene)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0008303"(caspase complex)|go:"GO:0008361"(regulation of cell size)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0016020"(membrane)|go:"GO:0016505"(peptidase activator activity involved in apoptotic process)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040034"(regulation of development, heterochronic)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043531"(ADP binding)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051432"(BH1 domain binding)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0089720"(caspase binding)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1904747"(positive regulation of apoptotic process involved in development)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002182(NB-ARC)|interpro:IPR011029(DEATH-like)|interpro:IPR016854(Apoptosis regulator, Ced-4)|interpro:IPR027417|interpro:IPR036388|interpro:IPR036390|rcsb pdb:2A5Y|rcsb pdb:3LQQ|rcsb pdb:3LQR|rcsb pdb:4M9S|rcsb pdb:4M9X|rcsb pdb:4M9Y|rcsb pdb:4M9Z|go:"GO:0030155"(regulation of cell adhesion)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:HFfz1WjirXjAkC5PNlCcB2NqcKE6239	rogid:nrCvl4N8Vx6zKbAnnOseTjz1RmA6239	rigid:MV1ialotG+xu+GKbv7P/X0J/oAo	false	his tag:n-n	35s radiolabel:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)