#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P05019	uniprotkb:P22692	intact:EBI-7902275|uniprotkb:Q14620|intact:MINT-6376445|uniprotkb:B2RWM7|uniprotkb:P01343|uniprotkb:E9PD02|intact:MINT-204184|ensembl:ENSP00000302665	intact:EBI-2831948|uniprotkb:B4E351|uniprotkb:Q9UCL6|uniprotkb:Q5U012|uniprotkb:A0N9W2|ensembl:ENSP00000269593	psi-mi:igf1_human(display_long)|uniprotkb:IGF1(gene name)|psi-mi:IGF1(display_short)|uniprotkb:IBP1(gene name synonym)|uniprotkb:Somatomedin-C(gene name synonym)|uniprotkb:Mechano growth factor(gene name synonym)	psi-mi:ibp4_human(display_long)|uniprotkb:IGFBP4(gene name)|psi-mi:IGFBP4(display_short)|uniprotkb:IBP4(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Sitar et al. (2006)	pubmed:16924115|doi:10.1073/pnas.0605652103|imex:IM-23890	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15598467|imex:IM-23890-1|dip:DIP-102899E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001104755.1|refseq:NP_000609.1|refseq:NP_001104754.1|go:"GO:0001775"(cell activation)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007165"(signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007517"(muscle organ development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009408"(response to heat)|go:"GO:0009441"(glycolate metabolic process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010560"(positive regulation of glycoprotein biosynthetic process)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014834"(skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration)|go:"GO:0014896"(muscle hypertrophy)|go:"GO:0014904"(myotube cell development)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016942"(insulin-like growth factor binding protein complex)|go:"GO:0030166"(proteoglycan biosynthetic process)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0034392"(negative regulation of smooth muscle cell apoptotic process)|go:"GO:0035630"(bone mineralization involved in bone maturation)|go:"GO:0035867"(alphav-beta3 integrin-IGF-1-IGF1R complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042060"(wound healing)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042567"(insulin-like growth factor ternary complex)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043568"(positive regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051450"(myoblast proliferation)|go:"GO:0060283"(negative regulation of oocyte development)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0150079"(negative regulation of neuroinflammatory response)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1904075"(positive regulation of trophectodermal cell proliferation)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905460"(negative regulation of vascular associated smooth muscle cell apoptotic process)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR016179(Insulin-like)|interpro:IPR022341|interpro:IPR022350|interpro:IPR022352|interpro:IPR022353|interpro:IPR036438|rcsb pdb:1B9G|rcsb pdb:1BQT|rcsb pdb:1GF1|rcsb pdb:1GZR|ensembl:ENSG00000017427(gene)|ensembl:ENST00000307046(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001501"(skeletal system development)|rcsb pdb:1GZY|rcsb pdb:1GZZ|rcsb pdb:1H02|rcsb pdb:1H59|rcsb pdb:1IMX|rcsb pdb:1PMX|rcsb pdb:1TGR|rcsb pdb:1WQJ|rcsb pdb:2DSP|rcsb pdb:2DSQ|rcsb pdb:2DSR|rcsb pdb:2GF1|rcsb pdb:3GF1|rcsb pdb:3LRI|rcsb pdb:4XSS|rcsb pdb:5U8Q|rcsb pdb:6FF3|rcsb pdb:6PYH|rcsb pdb:6RVA|reactome:R-HSA-114608|reactome:R-HSA-2404192|reactome:R-HSA-2428928|reactome:R-HSA-2428933|reactome:R-HSA-381426|reactome:R-HSA-422085|dip:DIP-41933N|dip:DIP-6021N	ensembl:ENSG00000141753(gene)|ensembl:ENST00000269593(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0031994"(insulin-like growth factor I binding)|go:"GO:0031995"(insulin-like growth factor II binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043567"(regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0043568"(positive regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0044342"(type B pancreatic cell proliferation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR000716(Thyroglobulin type-1)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR017891|interpro:IPR022321|interpro:IPR022327|interpro:IPR036857|mint:P22692|rcsb pdb:1WQJ|rcsb pdb:2DSP|rcsb pdb:2DSQ|rcsb pdb:2DSR|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_001543.2|dip:DIP-48432N	psi-mi:"MI:0465"(dip)	function:The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity|function:"Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) [MIM:608747]. IGF1 deficiency is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation"|comment:mint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:aZEsGQKF+moxGu7jxbhfvGucyTA9606	rogid:Zwh1MoGM8TnKpAFBRG7tZoOBvr89606	rigid:mRkyHKX9mK5tfOxV+N6m9Zqi2pg	false	sufficient binding region:49-118	sufficient binding region:22-113	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P08833	uniprotkb:P22692	intact:EBI-13646303|ensembl:ENSP00000275525|uniprotkb:A4D2F4|uniprotkb:D3DVL9|uniprotkb:Q8IYP5	intact:EBI-2831948|uniprotkb:B4E351|uniprotkb:Q9UCL6|uniprotkb:Q5U012|uniprotkb:A0N9W2|ensembl:ENSP00000269593	psi-mi:ibp1_human(display_long)|uniprotkb:IGFBP1(gene name)|psi-mi:IGFBP1(display_short)|uniprotkb:IBP1(gene name synonym)|uniprotkb:Placental protein 12(gene name synonym)	psi-mi:ibp4_human(display_long)|uniprotkb:IGFBP4(gene name)|psi-mi:IGFBP4(display_short)|uniprotkb:IBP4(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Sitar et al. (2006)	pubmed:16924115|doi:10.1073/pnas.0605652103|imex:IM-23890	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15598510|imex:IM-23890-3|dip:DIP-198032E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000146678(gene)|ensembl:ENST00000275525(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0007165"(signal transduction)|go:"GO:0007568"(aging)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031994"(insulin-like growth factor I binding)|go:"GO:0031995"(insulin-like growth factor II binding)|go:"GO:0042246"(tissue regeneration)|go:"GO:0043567"(regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR000716(Thyroglobulin type-1)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR017891|interpro:IPR022321|interpro:IPR022322|reactome:R-HSA-8957275|reactome:R-HSA-9615017|interpro:IPR036857|rcsb pdb:1ZT3|rcsb pdb:1ZT5|rcsb pdb:2DSQ|reactome:R-HSA-380994|reactome:R-HSA-381426|refseq:NP_000587.1|dip:DIP-59846N	ensembl:ENSG00000141753(gene)|ensembl:ENST00000269593(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0031994"(insulin-like growth factor I binding)|go:"GO:0031995"(insulin-like growth factor II binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043567"(regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0043568"(positive regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0044342"(type B pancreatic cell proliferation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR000716(Thyroglobulin type-1)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR017891|interpro:IPR022321|interpro:IPR022327|interpro:IPR036857|mint:P22692|rcsb pdb:1WQJ|rcsb pdb:2DSP|rcsb pdb:2DSQ|rcsb pdb:2DSR|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_001543.2|dip:DIP-48432N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:508HADo+AQGlRdHL3Yqk7Hyhjv09606	rogid:Zwh1MoGM8TnKpAFBRG7tZoOBvr89606	rigid:ELCGaQDTV2jO1Z9bHOpwJiZsBF8	false	sufficient binding region:166-259	sufficient binding region:22-113	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P08833	uniprotkb:P05019	intact:EBI-13646303|ensembl:ENSP00000275525|uniprotkb:A4D2F4|uniprotkb:D3DVL9|uniprotkb:Q8IYP5	intact:EBI-7902275|uniprotkb:Q14620|intact:MINT-6376445|uniprotkb:B2RWM7|uniprotkb:P01343|uniprotkb:E9PD02|intact:MINT-204184|ensembl:ENSP00000302665	psi-mi:ibp1_human(display_long)|uniprotkb:IGFBP1(gene name)|psi-mi:IGFBP1(display_short)|uniprotkb:IBP1(gene name synonym)|uniprotkb:Placental protein 12(gene name synonym)	psi-mi:igf1_human(display_long)|uniprotkb:IGF1(gene name)|psi-mi:IGF1(display_short)|uniprotkb:IBP1(gene name synonym)|uniprotkb:Somatomedin-C(gene name synonym)|uniprotkb:Mechano growth factor(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Sitar et al. (2006)	pubmed:16924115|doi:10.1073/pnas.0605652103|imex:IM-23890	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15598510|imex:IM-23890-3|dip:DIP-198032E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000146678(gene)|ensembl:ENST00000275525(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0007165"(signal transduction)|go:"GO:0007568"(aging)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031994"(insulin-like growth factor I binding)|go:"GO:0031995"(insulin-like growth factor II binding)|go:"GO:0042246"(tissue regeneration)|go:"GO:0043567"(regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR000716(Thyroglobulin type-1)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR017891|interpro:IPR022321|interpro:IPR022322|reactome:R-HSA-8957275|reactome:R-HSA-9615017|interpro:IPR036857|rcsb pdb:1ZT3|rcsb pdb:1ZT5|rcsb pdb:2DSQ|reactome:R-HSA-380994|reactome:R-HSA-381426|refseq:NP_000587.1|dip:DIP-59846N	refseq:NP_001104755.1|refseq:NP_000609.1|refseq:NP_001104754.1|go:"GO:0001775"(cell activation)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007165"(signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007517"(muscle organ development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009408"(response to heat)|go:"GO:0009441"(glycolate metabolic process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010560"(positive regulation of glycoprotein biosynthetic process)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014834"(skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration)|go:"GO:0014896"(muscle hypertrophy)|go:"GO:0014904"(myotube cell development)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016942"(insulin-like growth factor binding protein complex)|go:"GO:0030166"(proteoglycan biosynthetic process)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0034392"(negative regulation of smooth muscle cell apoptotic process)|go:"GO:0035630"(bone mineralization involved in bone maturation)|go:"GO:0035867"(alphav-beta3 integrin-IGF-1-IGF1R complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042060"(wound healing)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042567"(insulin-like growth factor ternary complex)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043568"(positive regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051450"(myoblast proliferation)|go:"GO:0060283"(negative regulation of oocyte development)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0150079"(negative regulation of neuroinflammatory response)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1904075"(positive regulation of trophectodermal cell proliferation)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905460"(negative regulation of vascular associated smooth muscle cell apoptotic process)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR016179(Insulin-like)|interpro:IPR022341|interpro:IPR022350|interpro:IPR022352|interpro:IPR022353|interpro:IPR036438|rcsb pdb:1B9G|rcsb pdb:1BQT|rcsb pdb:1GF1|rcsb pdb:1GZR|ensembl:ENSG00000017427(gene)|ensembl:ENST00000307046(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001501"(skeletal system development)|rcsb pdb:1GZY|rcsb pdb:1GZZ|rcsb pdb:1H02|rcsb pdb:1H59|rcsb pdb:1IMX|rcsb pdb:1PMX|rcsb pdb:1TGR|rcsb pdb:1WQJ|rcsb pdb:2DSP|rcsb pdb:2DSQ|rcsb pdb:2DSR|rcsb pdb:2GF1|rcsb pdb:3GF1|rcsb pdb:3LRI|rcsb pdb:4XSS|rcsb pdb:5U8Q|rcsb pdb:6FF3|rcsb pdb:6PYH|rcsb pdb:6RVA|reactome:R-HSA-114608|reactome:R-HSA-2404192|reactome:R-HSA-2428928|reactome:R-HSA-2428933|reactome:R-HSA-381426|reactome:R-HSA-422085|dip:DIP-41933N|dip:DIP-6021N	psi-mi:"MI:0465"(dip)	-	function:The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity|function:"Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) [MIM:608747]. IGF1 deficiency is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation"|comment:mint	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:508HADo+AQGlRdHL3Yqk7Hyhjv09606	rogid:aZEsGQKF+moxGu7jxbhfvGucyTA9606	rigid:ELCGaQDTV2jO1Z9bHOpwJiZsBF8	false	sufficient binding region:166-259	sufficient binding region:49-118	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P05019	uniprotkb:P22692	intact:EBI-7902275|uniprotkb:Q14620|intact:MINT-6376445|uniprotkb:B2RWM7|uniprotkb:P01343|uniprotkb:E9PD02|intact:MINT-204184|ensembl:ENSP00000302665	intact:EBI-2831948|uniprotkb:B4E351|uniprotkb:Q9UCL6|uniprotkb:Q5U012|uniprotkb:A0N9W2|ensembl:ENSP00000269593	psi-mi:igf1_human(display_long)|uniprotkb:IGF1(gene name)|psi-mi:IGF1(display_short)|uniprotkb:IBP1(gene name synonym)|uniprotkb:Somatomedin-C(gene name synonym)|uniprotkb:Mechano growth factor(gene name synonym)	psi-mi:ibp4_human(display_long)|uniprotkb:IGFBP4(gene name)|psi-mi:IGFBP4(display_short)|uniprotkb:IBP4(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Sitar et al. (2006)	pubmed:16924115|doi:10.1073/pnas.0605652103|imex:IM-23890	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15598488|imex:IM-23890-2|dip:DIP-102899E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001104755.1|refseq:NP_000609.1|refseq:NP_001104754.1|go:"GO:0001775"(cell activation)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007165"(signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007517"(muscle organ development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009408"(response to heat)|go:"GO:0009441"(glycolate metabolic process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010560"(positive regulation of glycoprotein biosynthetic process)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014834"(skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration)|go:"GO:0014896"(muscle hypertrophy)|go:"GO:0014904"(myotube cell development)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016942"(insulin-like growth factor binding protein complex)|go:"GO:0030166"(proteoglycan biosynthetic process)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0034392"(negative regulation of smooth muscle cell apoptotic process)|go:"GO:0035630"(bone mineralization involved in bone maturation)|go:"GO:0035867"(alphav-beta3 integrin-IGF-1-IGF1R complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042060"(wound healing)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042567"(insulin-like growth factor ternary complex)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043568"(positive regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051450"(myoblast proliferation)|go:"GO:0060283"(negative regulation of oocyte development)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0150079"(negative regulation of neuroinflammatory response)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1904075"(positive regulation of trophectodermal cell proliferation)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905460"(negative regulation of vascular associated smooth muscle cell apoptotic process)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR016179(Insulin-like)|interpro:IPR022341|interpro:IPR022350|interpro:IPR022352|interpro:IPR022353|interpro:IPR036438|rcsb pdb:1B9G|rcsb pdb:1BQT|rcsb pdb:1GF1|rcsb pdb:1GZR|ensembl:ENSG00000017427(gene)|ensembl:ENST00000307046(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001501"(skeletal system development)|rcsb pdb:1GZY|rcsb pdb:1GZZ|rcsb pdb:1H02|rcsb pdb:1H59|rcsb pdb:1IMX|rcsb pdb:1PMX|rcsb pdb:1TGR|rcsb pdb:1WQJ|rcsb pdb:2DSP|rcsb pdb:2DSQ|rcsb pdb:2DSR|rcsb pdb:2GF1|rcsb pdb:3GF1|rcsb pdb:3LRI|rcsb pdb:4XSS|rcsb pdb:5U8Q|rcsb pdb:6FF3|rcsb pdb:6PYH|rcsb pdb:6RVA|reactome:R-HSA-114608|reactome:R-HSA-2404192|reactome:R-HSA-2428928|reactome:R-HSA-2428933|reactome:R-HSA-381426|reactome:R-HSA-422085|dip:DIP-41933N|dip:DIP-6021N	ensembl:ENSG00000141753(gene)|ensembl:ENST00000269593(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0031994"(insulin-like growth factor I binding)|go:"GO:0031995"(insulin-like growth factor II binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043567"(regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0043568"(positive regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0044342"(type B pancreatic cell proliferation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR000716(Thyroglobulin type-1)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR017891|interpro:IPR022321|interpro:IPR022327|interpro:IPR036857|mint:P22692|rcsb pdb:1WQJ|rcsb pdb:2DSP|rcsb pdb:2DSQ|rcsb pdb:2DSR|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_001543.2|dip:DIP-48432N	psi-mi:"MI:0465"(dip)	function:The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity|function:"Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) [MIM:608747]. IGF1 deficiency is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation"|comment:mint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:aZEsGQKF+moxGu7jxbhfvGucyTA9606	rogid:Zwh1MoGM8TnKpAFBRG7tZoOBvr89606	rigid:mRkyHKX9mK5tfOxV+N6m9Zqi2pg	false	sufficient binding region:49-118	sufficient binding region:22-113	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P05019	uniprotkb:P22692	intact:EBI-7902275|uniprotkb:Q14620|intact:MINT-6376445|uniprotkb:B2RWM7|uniprotkb:P01343|uniprotkb:E9PD02|intact:MINT-204184|ensembl:ENSP00000302665	intact:EBI-2831948|uniprotkb:B4E351|uniprotkb:Q9UCL6|uniprotkb:Q5U012|uniprotkb:A0N9W2|ensembl:ENSP00000269593	psi-mi:igf1_human(display_long)|uniprotkb:IGF1(gene name)|psi-mi:IGF1(display_short)|uniprotkb:IBP1(gene name synonym)|uniprotkb:Somatomedin-C(gene name synonym)|uniprotkb:Mechano growth factor(gene name synonym)	psi-mi:ibp4_human(display_long)|uniprotkb:IGFBP4(gene name)|psi-mi:IGFBP4(display_short)|uniprotkb:IBP4(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Sitar et al. (2006)	pubmed:16924115|doi:10.1073/pnas.0605652103|imex:IM-23890	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15598534|imex:IM-23890-4|dip:DIP-102899E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001104755.1|refseq:NP_000609.1|refseq:NP_001104754.1|go:"GO:0001775"(cell activation)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007165"(signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007517"(muscle organ development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009408"(response to heat)|go:"GO:0009441"(glycolate metabolic process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010560"(positive regulation of glycoprotein biosynthetic process)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014834"(skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration)|go:"GO:0014896"(muscle hypertrophy)|go:"GO:0014904"(myotube cell development)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016942"(insulin-like growth factor binding protein complex)|go:"GO:0030166"(proteoglycan biosynthetic process)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0034392"(negative regulation of smooth muscle cell apoptotic process)|go:"GO:0035630"(bone mineralization involved in bone maturation)|go:"GO:0035867"(alphav-beta3 integrin-IGF-1-IGF1R complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042060"(wound healing)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042567"(insulin-like growth factor ternary complex)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043568"(positive regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051450"(myoblast proliferation)|go:"GO:0060283"(negative regulation of oocyte development)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0150079"(negative regulation of neuroinflammatory response)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1904075"(positive regulation of trophectodermal cell proliferation)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905460"(negative regulation of vascular associated smooth muscle cell apoptotic process)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR016179(Insulin-like)|interpro:IPR022341|interpro:IPR022350|interpro:IPR022352|interpro:IPR022353|interpro:IPR036438|rcsb pdb:1B9G|rcsb pdb:1BQT|rcsb pdb:1GF1|rcsb pdb:1GZR|ensembl:ENSG00000017427(gene)|ensembl:ENST00000307046(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001501"(skeletal system development)|rcsb pdb:1GZY|rcsb pdb:1GZZ|rcsb pdb:1H02|rcsb pdb:1H59|rcsb pdb:1IMX|rcsb pdb:1PMX|rcsb pdb:1TGR|rcsb pdb:1WQJ|rcsb pdb:2DSP|rcsb pdb:2DSQ|rcsb pdb:2DSR|rcsb pdb:2GF1|rcsb pdb:3GF1|rcsb pdb:3LRI|rcsb pdb:4XSS|rcsb pdb:5U8Q|rcsb pdb:6FF3|rcsb pdb:6PYH|rcsb pdb:6RVA|reactome:R-HSA-114608|reactome:R-HSA-2404192|reactome:R-HSA-2428928|reactome:R-HSA-2428933|reactome:R-HSA-381426|reactome:R-HSA-422085|dip:DIP-41933N|dip:DIP-6021N	ensembl:ENSG00000141753(gene)|ensembl:ENST00000269593(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0031994"(insulin-like growth factor I binding)|go:"GO:0031995"(insulin-like growth factor II binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043567"(regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0043568"(positive regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0044342"(type B pancreatic cell proliferation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR000716(Thyroglobulin type-1)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR017891|interpro:IPR022321|interpro:IPR022327|interpro:IPR036857|mint:P22692|rcsb pdb:1WQJ|rcsb pdb:2DSP|rcsb pdb:2DSQ|rcsb pdb:2DSR|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_001543.2|dip:DIP-48432N	psi-mi:"MI:0465"(dip)	function:The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity|function:"Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) [MIM:608747]. IGF1 deficiency is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation"|comment:mint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:aZEsGQKF+moxGu7jxbhfvGucyTA9606	rogid:Zwh1MoGM8TnKpAFBRG7tZoOBvr89606	rigid:mRkyHKX9mK5tfOxV+N6m9Zqi2pg	false	sufficient binding region:49-118	sufficient binding region:22-113	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)