#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q96DU3	uniprotkb:O60880	intact:EBI-14058448|uniprotkb:A6NMW2|uniprotkb:B2R8X8|uniprotkb:Q14CF0|uniprotkb:Q5TAS4|uniprotkb:Q5TAS6|uniprotkb:Q5TAT3|uniprotkb:Q96DV0|ensembl:ENSP00000357036	intact:EBI-6983382|ensembl:ENSP00000360181|uniprotkb:O95386|uniprotkb:Q6FGS6|uniprotkb:O95385|intact:MINT-113697|uniprotkb:A8MSW0|uniprotkb:O95384|uniprotkb:O95383|uniprotkb:Q9UNR0	psi-mi:slaf6_human(display_long)|uniprotkb:KALI(gene name synonym)|uniprotkb:SLAMF6(gene name)|psi-mi:SLAMF6(display_short)|uniprotkb:Activating NK receptor(gene name synonym)|uniprotkb:NK-T-B-antigen(gene name synonym)|uniprotkb:UNQ6123/PRO20080(orf name)	psi-mi:sh21a_human(display_long)|uniprotkb:SH2D1A(gene name)|psi-mi:SH2D1A(display_short)|uniprotkb:DSHP(gene name synonym)|uniprotkb:SAP(gene name synonym)|uniprotkb:Signaling lymphocytic activation molecule-associated protein(gene name synonym)|uniprotkb:T-cell signal transduction molecule SAP(gene name synonym)|uniprotkb:Duncan disease SH2-protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Eissmann et al. (2006)	imex:IM-25791|pubmed:16920955	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-15101193|imex:IM-25791-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171643.1|refseq:NP_001171644.1|refseq:NP_001171645.1|refseq:NP_443163.1|ensembl:ENSG00000162739(gene)|ensembl:ENST00000368057(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0045087"(innate immune response)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2IF7|reactome:R-HSA-198933	rcsb pdb:1D4W|rcsb pdb:1KA6|rcsb pdb:1KA7|rcsb pdb:1M27|reactome:R-HSA-198933|ensembl:ENSG00000183918(gene)|ensembl:ENST00000371139(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006959"(humoral immune response)|go:"GO:0006968"(cellular defense response)|rcsb pdb:1D4T|go:"GO:0007267"(cell-cell signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR017289(SH2 protein 1A)|interpro:IPR035876|interpro:IPR036860|rcsb pdb:1D1Z|refseq:NP_001108409.1|refseq:NP_002342.1|dip:DIP-40768N	-	-	comment:mint|function:Inhibitor of the SLAM self-association. Acts by blocking recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to a docking site in the slam cytoplasmic region|function:"Defects in SH2D1A are a cause of lymphoproliferative syndrome X-linked type 1 (XLP1) [MIM:308240]; also known as X-linked lymphoproliferative disease (XLPD) or Duncan disease. XLP is a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus (EBV). Symptoms include severe or fatal mononucleosis, acquired hypogammaglobulinemia, pancytopenia and malignant lymphoma"	figure legend:3A, 4A/B|antagonist:"CHEBI:78332  -Src kinase inhibitor,  PP1"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-nk_cells)|taxid:9606(human-Natural Killer cells)	-	2017/05/09	2017/06/13	rogid:rUujUH968ooEkRgUiIeCBZbsjCs9606	rogid:tJL+FA6RUPeEknwUp85WT2p0+/c9606	rigid:LARmFGm9FHhm6FEQgzDIMA9CErM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q96DU3	uniprotkb:O14796	intact:EBI-14058448|uniprotkb:A6NMW2|uniprotkb:B2R8X8|uniprotkb:Q14CF0|uniprotkb:Q5TAS4|uniprotkb:Q5TAS6|uniprotkb:Q5TAT3|uniprotkb:Q96DV0|ensembl:ENSP00000357036	intact:EBI-3923013|uniprotkb:Q8NI18|uniprotkb:B2RBN6|uniprotkb:Q969K9|uniprotkb:Q5T0L1|ensembl:ENSP00000356906	psi-mi:slaf6_human(display_long)|uniprotkb:KALI(gene name synonym)|uniprotkb:SLAMF6(gene name)|psi-mi:SLAMF6(display_short)|uniprotkb:Activating NK receptor(gene name synonym)|uniprotkb:NK-T-B-antigen(gene name synonym)|uniprotkb:UNQ6123/PRO20080(orf name)	psi-mi:sh21b_human(display_long)|uniprotkb:SH2D1B(gene name)|psi-mi:SH2D1B(display_short)|uniprotkb:EAT2(gene name synonym)|uniprotkb:EWS/FLI1-activated transcript 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Eissmann et al. (2006)	imex:IM-25791|pubmed:16920955	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-15101193|imex:IM-25791-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171643.1|refseq:NP_001171644.1|refseq:NP_001171645.1|refseq:NP_443163.1|ensembl:ENSG00000162739(gene)|ensembl:ENST00000368057(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0045087"(innate immune response)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2IF7|reactome:R-HSA-198933	refseq:NP_444512.2|ensembl:ENSG00000198574(gene)|ensembl:ENST00000367929(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002366"(leukocyte activation involved in immune response)|go:"GO:0002717"(positive regulation of natural killer cell mediated immunity)|go:"GO:0005829"(cytosol)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|interpro:IPR000980(SH2 motif)|interpro:IPR035049|interpro:IPR036860|rcsb pdb:5KAZ|reactome:R-HSA-198933	-	-	-	figure legend:3A, 4A/B|antagonist:"CHEBI:78332  -Src kinase inhibitor,  PP1"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-nk_cells)|taxid:9606(human-Natural Killer cells)	-	2017/05/09	2017/06/13	rogid:rUujUH968ooEkRgUiIeCBZbsjCs9606	rogid:sbsE/jcSEsUrt8tK/EDz33pQqNQ9606	rigid:LARmFGm9FHhm6FEQgzDIMA9CErM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O60880	uniprotkb:Q9BZW8	intact:EBI-6983382|ensembl:ENSP00000360181|uniprotkb:O95386|uniprotkb:Q6FGS6|uniprotkb:O95385|intact:MINT-113697|uniprotkb:A8MSW0|uniprotkb:O95384|uniprotkb:O95383|uniprotkb:Q9UNR0	intact:EBI-1580565|uniprotkb:Q96T47|uniprotkb:Q9NQD2|uniprotkb:Q9NQD3|uniprotkb:Q9Y288|uniprotkb:Q5VYI2|uniprotkb:Q5VYI6|uniprotkb:Q5VYI7|ensembl:ENSP00000357012	psi-mi:sh21a_human(display_long)|uniprotkb:SH2D1A(gene name)|psi-mi:SH2D1A(display_short)|uniprotkb:DSHP(gene name synonym)|uniprotkb:SAP(gene name synonym)|uniprotkb:Signaling lymphocytic activation molecule-associated protein(gene name synonym)|uniprotkb:T-cell signal transduction molecule SAP(gene name synonym)|uniprotkb:Duncan disease SH2-protein(gene name synonym)	psi-mi:cd244_human(display_long)|uniprotkb:NK cell type I receptor protein 2B4(gene name synonym)|uniprotkb:NK cell activation-inducing ligand(gene name synonym)|uniprotkb:CD244(gene name)|psi-mi:CD244(display_short)|uniprotkb:2B4(gene name synonym)|uniprotkb:SLAM family member 4(gene name synonym)|uniprotkb:Signaling lymphocytic activation molecule 4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Eissmann et al. (2006)	imex:IM-25791|pubmed:16920955	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-15101208|imex:IM-25791-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:1D4W|rcsb pdb:1KA6|rcsb pdb:1KA7|rcsb pdb:1M27|reactome:R-HSA-198933|ensembl:ENSG00000183918(gene)|ensembl:ENST00000371139(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006959"(humoral immune response)|go:"GO:0006968"(cellular defense response)|rcsb pdb:1D4T|go:"GO:0007267"(cell-cell signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR017289(SH2 protein 1A)|interpro:IPR035876|interpro:IPR036860|rcsb pdb:1D1Z|refseq:NP_001108409.1|refseq:NP_002342.1|dip:DIP-40768N	refseq:XP_011507924.1|refseq:NP_001160135.1|refseq:NP_001160136.1|refseq:NP_057466.1|dip:DIP-40331N|ensembl:ENSG00000122223(gene)|ensembl:ENST00000368033(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002323"(natural killer cell activation involved in immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0060732"(positive regulation of inositol phosphate biosynthetic process)|go:"GO:0071663"(positive regulation of granzyme B production)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR024303|interpro:IPR024304|interpro:IPR036179|reactome:R-HSA-202733	-	comment:mint|function:Inhibitor of the SLAM self-association. Acts by blocking recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to a docking site in the slam cytoplasmic region|function:"Defects in SH2D1A are a cause of lymphoproliferative syndrome X-linked type 1 (XLP1) [MIM:308240]; also known as X-linked lymphoproliferative disease (XLPD) or Duncan disease. XLP is a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus (EBV). Symptoms include severe or fatal mononucleosis, acquired hypogammaglobulinemia, pancytopenia and malignant lymphoma"	-	figure legend:5A|comment:IL-2-activated primary human NK cells.|comment:A very weak association with CD244 was detected.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-nk_cells)|taxid:9606(human-Natural Killer cells)	-	2017/05/09	2017/06/13	rogid:tJL+FA6RUPeEknwUp85WT2p0+/c9606	rogid:QORMx+ZJyNjvraEeZH1rBgcD2bU9606	rigid:cA9BnJLE1kWcjrI805Mn3V+X2eg	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O60880	uniprotkb:Q96DU3	intact:EBI-6983382|ensembl:ENSP00000360181|uniprotkb:O95386|uniprotkb:Q6FGS6|uniprotkb:O95385|intact:MINT-113697|uniprotkb:A8MSW0|uniprotkb:O95384|uniprotkb:O95383|uniprotkb:Q9UNR0	intact:EBI-14058448|uniprotkb:A6NMW2|uniprotkb:B2R8X8|uniprotkb:Q14CF0|uniprotkb:Q5TAS4|uniprotkb:Q5TAS6|uniprotkb:Q5TAT3|uniprotkb:Q96DV0|ensembl:ENSP00000357036	psi-mi:sh21a_human(display_long)|uniprotkb:SH2D1A(gene name)|psi-mi:SH2D1A(display_short)|uniprotkb:DSHP(gene name synonym)|uniprotkb:SAP(gene name synonym)|uniprotkb:Signaling lymphocytic activation molecule-associated protein(gene name synonym)|uniprotkb:T-cell signal transduction molecule SAP(gene name synonym)|uniprotkb:Duncan disease SH2-protein(gene name synonym)	psi-mi:slaf6_human(display_long)|uniprotkb:KALI(gene name synonym)|uniprotkb:SLAMF6(gene name)|psi-mi:SLAMF6(display_short)|uniprotkb:Activating NK receptor(gene name synonym)|uniprotkb:NK-T-B-antigen(gene name synonym)|uniprotkb:UNQ6123/PRO20080(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Eissmann et al. (2006)	imex:IM-25791|pubmed:16920955	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-15101208|imex:IM-25791-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:1D4W|rcsb pdb:1KA6|rcsb pdb:1KA7|rcsb pdb:1M27|reactome:R-HSA-198933|ensembl:ENSG00000183918(gene)|ensembl:ENST00000371139(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006959"(humoral immune response)|go:"GO:0006968"(cellular defense response)|rcsb pdb:1D4T|go:"GO:0007267"(cell-cell signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR017289(SH2 protein 1A)|interpro:IPR035876|interpro:IPR036860|rcsb pdb:1D1Z|refseq:NP_001108409.1|refseq:NP_002342.1|dip:DIP-40768N	refseq:NP_001171643.1|refseq:NP_001171644.1|refseq:NP_001171645.1|refseq:NP_443163.1|ensembl:ENSG00000162739(gene)|ensembl:ENST00000368057(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0045087"(innate immune response)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2IF7|reactome:R-HSA-198933	-	comment:mint|function:Inhibitor of the SLAM self-association. Acts by blocking recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to a docking site in the slam cytoplasmic region|function:"Defects in SH2D1A are a cause of lymphoproliferative syndrome X-linked type 1 (XLP1) [MIM:308240]; also known as X-linked lymphoproliferative disease (XLPD) or Duncan disease. XLP is a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus (EBV). Symptoms include severe or fatal mononucleosis, acquired hypogammaglobulinemia, pancytopenia and malignant lymphoma"	-	figure legend:5A|comment:IL-2-activated primary human NK cells.|comment:A very weak association with CD244 was detected.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-nk_cells)|taxid:9606(human-Natural Killer cells)	-	2017/05/09	2017/06/13	rogid:tJL+FA6RUPeEknwUp85WT2p0+/c9606	rogid:rUujUH968ooEkRgUiIeCBZbsjCs9606	rigid:cA9BnJLE1kWcjrI805Mn3V+X2eg	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O60880	uniprotkb:O14796	intact:EBI-6983382|ensembl:ENSP00000360181|uniprotkb:O95386|uniprotkb:Q6FGS6|uniprotkb:O95385|intact:MINT-113697|uniprotkb:A8MSW0|uniprotkb:O95384|uniprotkb:O95383|uniprotkb:Q9UNR0	intact:EBI-3923013|uniprotkb:Q8NI18|uniprotkb:B2RBN6|uniprotkb:Q969K9|uniprotkb:Q5T0L1|ensembl:ENSP00000356906	psi-mi:sh21a_human(display_long)|uniprotkb:SH2D1A(gene name)|psi-mi:SH2D1A(display_short)|uniprotkb:DSHP(gene name synonym)|uniprotkb:SAP(gene name synonym)|uniprotkb:Signaling lymphocytic activation molecule-associated protein(gene name synonym)|uniprotkb:T-cell signal transduction molecule SAP(gene name synonym)|uniprotkb:Duncan disease SH2-protein(gene name synonym)	psi-mi:sh21b_human(display_long)|uniprotkb:SH2D1B(gene name)|psi-mi:SH2D1B(display_short)|uniprotkb:EAT2(gene name synonym)|uniprotkb:EWS/FLI1-activated transcript 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Eissmann et al. (2006)	imex:IM-25791|pubmed:16920955	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-15101208|imex:IM-25791-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:1D4W|rcsb pdb:1KA6|rcsb pdb:1KA7|rcsb pdb:1M27|reactome:R-HSA-198933|ensembl:ENSG00000183918(gene)|ensembl:ENST00000371139(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006959"(humoral immune response)|go:"GO:0006968"(cellular defense response)|rcsb pdb:1D4T|go:"GO:0007267"(cell-cell signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR017289(SH2 protein 1A)|interpro:IPR035876|interpro:IPR036860|rcsb pdb:1D1Z|refseq:NP_001108409.1|refseq:NP_002342.1|dip:DIP-40768N	refseq:NP_444512.2|ensembl:ENSG00000198574(gene)|ensembl:ENST00000367929(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002366"(leukocyte activation involved in immune response)|go:"GO:0002717"(positive regulation of natural killer cell mediated immunity)|go:"GO:0005829"(cytosol)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|interpro:IPR000980(SH2 motif)|interpro:IPR035049|interpro:IPR036860|rcsb pdb:5KAZ|reactome:R-HSA-198933	-	comment:mint|function:Inhibitor of the SLAM self-association. Acts by blocking recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to a docking site in the slam cytoplasmic region|function:"Defects in SH2D1A are a cause of lymphoproliferative syndrome X-linked type 1 (XLP1) [MIM:308240]; also known as X-linked lymphoproliferative disease (XLPD) or Duncan disease. XLP is a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus (EBV). Symptoms include severe or fatal mononucleosis, acquired hypogammaglobulinemia, pancytopenia and malignant lymphoma"	-	figure legend:5A|comment:IL-2-activated primary human NK cells.|comment:A very weak association with CD244 was detected.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-nk_cells)|taxid:9606(human-Natural Killer cells)	-	2017/05/09	2017/06/13	rogid:tJL+FA6RUPeEknwUp85WT2p0+/c9606	rogid:sbsE/jcSEsUrt8tK/EDz33pQqNQ9606	rigid:cA9BnJLE1kWcjrI805Mn3V+X2eg	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O60880	uniprotkb:Q96DU3	intact:EBI-6983382|ensembl:ENSP00000360181|uniprotkb:O95386|uniprotkb:Q6FGS6|uniprotkb:O95385|intact:MINT-113697|uniprotkb:A8MSW0|uniprotkb:O95384|uniprotkb:O95383|uniprotkb:Q9UNR0	intact:EBI-14058448|uniprotkb:A6NMW2|uniprotkb:B2R8X8|uniprotkb:Q14CF0|uniprotkb:Q5TAS4|uniprotkb:Q5TAS6|uniprotkb:Q5TAT3|uniprotkb:Q96DV0|ensembl:ENSP00000357036	psi-mi:sh21a_human(display_long)|uniprotkb:SH2D1A(gene name)|psi-mi:SH2D1A(display_short)|uniprotkb:DSHP(gene name synonym)|uniprotkb:SAP(gene name synonym)|uniprotkb:Signaling lymphocytic activation molecule-associated protein(gene name synonym)|uniprotkb:T-cell signal transduction molecule SAP(gene name synonym)|uniprotkb:Duncan disease SH2-protein(gene name synonym)	psi-mi:slaf6_human(display_long)|uniprotkb:KALI(gene name synonym)|uniprotkb:SLAMF6(gene name)|psi-mi:SLAMF6(display_short)|uniprotkb:Activating NK receptor(gene name synonym)|uniprotkb:NK-T-B-antigen(gene name synonym)|uniprotkb:UNQ6123/PRO20080(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Eissmann et al. (2006)	imex:IM-25791|pubmed:16920955	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-15101217|imex:IM-25791-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:1D4W|rcsb pdb:1KA6|rcsb pdb:1KA7|rcsb pdb:1M27|reactome:R-HSA-198933|ensembl:ENSG00000183918(gene)|ensembl:ENST00000371139(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006959"(humoral immune response)|go:"GO:0006968"(cellular defense response)|rcsb pdb:1D4T|go:"GO:0007267"(cell-cell signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR017289(SH2 protein 1A)|interpro:IPR035876|interpro:IPR036860|rcsb pdb:1D1Z|refseq:NP_001108409.1|refseq:NP_002342.1|dip:DIP-40768N	refseq:NP_001171643.1|refseq:NP_001171644.1|refseq:NP_001171645.1|refseq:NP_443163.1|ensembl:ENSG00000162739(gene)|ensembl:ENST00000368057(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0045087"(innate immune response)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2IF7|reactome:R-HSA-198933	-	comment:mint|function:Inhibitor of the SLAM self-association. Acts by blocking recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to a docking site in the slam cytoplasmic region|function:"Defects in SH2D1A are a cause of lymphoproliferative syndrome X-linked type 1 (XLP1) [MIM:308240]; also known as X-linked lymphoproliferative disease (XLPD) or Duncan disease. XLP is a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus (EBV). Symptoms include severe or fatal mononucleosis, acquired hypogammaglobulinemia, pancytopenia and malignant lymphoma"	-	figure legend:5C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-nkl)|taxid:9606(Homo sapiens)	-	2017/05/09	2017/06/13	rogid:tJL+FA6RUPeEknwUp85WT2p0+/c9606	rogid:rUujUH968ooEkRgUiIeCBZbsjCs9606	rigid:LARmFGm9FHhm6FEQgzDIMA9CErM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O60880	uniprotkb:O14796	intact:EBI-6983382|ensembl:ENSP00000360181|uniprotkb:O95386|uniprotkb:Q6FGS6|uniprotkb:O95385|intact:MINT-113697|uniprotkb:A8MSW0|uniprotkb:O95384|uniprotkb:O95383|uniprotkb:Q9UNR0	intact:EBI-3923013|uniprotkb:Q8NI18|uniprotkb:B2RBN6|uniprotkb:Q969K9|uniprotkb:Q5T0L1|ensembl:ENSP00000356906	psi-mi:sh21a_human(display_long)|uniprotkb:SH2D1A(gene name)|psi-mi:SH2D1A(display_short)|uniprotkb:DSHP(gene name synonym)|uniprotkb:SAP(gene name synonym)|uniprotkb:Signaling lymphocytic activation molecule-associated protein(gene name synonym)|uniprotkb:T-cell signal transduction molecule SAP(gene name synonym)|uniprotkb:Duncan disease SH2-protein(gene name synonym)	psi-mi:sh21b_human(display_long)|uniprotkb:SH2D1B(gene name)|psi-mi:SH2D1B(display_short)|uniprotkb:EAT2(gene name synonym)|uniprotkb:EWS/FLI1-activated transcript 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Eissmann et al. (2006)	imex:IM-25791|pubmed:16920955	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-15101217|imex:IM-25791-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:1D4W|rcsb pdb:1KA6|rcsb pdb:1KA7|rcsb pdb:1M27|reactome:R-HSA-198933|ensembl:ENSG00000183918(gene)|ensembl:ENST00000371139(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006959"(humoral immune response)|go:"GO:0006968"(cellular defense response)|rcsb pdb:1D4T|go:"GO:0007267"(cell-cell signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR017289(SH2 protein 1A)|interpro:IPR035876|interpro:IPR036860|rcsb pdb:1D1Z|refseq:NP_001108409.1|refseq:NP_002342.1|dip:DIP-40768N	refseq:NP_444512.2|ensembl:ENSG00000198574(gene)|ensembl:ENST00000367929(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002366"(leukocyte activation involved in immune response)|go:"GO:0002717"(positive regulation of natural killer cell mediated immunity)|go:"GO:0005829"(cytosol)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|interpro:IPR000980(SH2 motif)|interpro:IPR035049|interpro:IPR036860|rcsb pdb:5KAZ|reactome:R-HSA-198933	-	comment:mint|function:Inhibitor of the SLAM self-association. Acts by blocking recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to a docking site in the slam cytoplasmic region|function:"Defects in SH2D1A are a cause of lymphoproliferative syndrome X-linked type 1 (XLP1) [MIM:308240]; also known as X-linked lymphoproliferative disease (XLPD) or Duncan disease. XLP is a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus (EBV). Symptoms include severe or fatal mononucleosis, acquired hypogammaglobulinemia, pancytopenia and malignant lymphoma"	-	figure legend:5C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-nkl)|taxid:9606(Homo sapiens)	-	2017/05/09	2017/06/13	rogid:tJL+FA6RUPeEknwUp85WT2p0+/c9606	rogid:sbsE/jcSEsUrt8tK/EDz33pQqNQ9606	rigid:LARmFGm9FHhm6FEQgzDIMA9CErM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q96DU3	uniprotkb:O14796	intact:EBI-14058448|uniprotkb:A6NMW2|uniprotkb:B2R8X8|uniprotkb:Q14CF0|uniprotkb:Q5TAS4|uniprotkb:Q5TAS6|uniprotkb:Q5TAT3|uniprotkb:Q96DV0|ensembl:ENSP00000357036	intact:EBI-3923013|uniprotkb:Q8NI18|uniprotkb:B2RBN6|uniprotkb:Q969K9|uniprotkb:Q5T0L1|ensembl:ENSP00000356906	psi-mi:slaf6_human(display_long)|uniprotkb:KALI(gene name synonym)|uniprotkb:SLAMF6(gene name)|psi-mi:SLAMF6(display_short)|uniprotkb:Activating NK receptor(gene name synonym)|uniprotkb:NK-T-B-antigen(gene name synonym)|uniprotkb:UNQ6123/PRO20080(orf name)	psi-mi:sh21b_human(display_long)|uniprotkb:SH2D1B(gene name)|psi-mi:SH2D1B(display_short)|uniprotkb:EAT2(gene name synonym)|uniprotkb:EWS/FLI1-activated transcript 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Eissmann et al. (2006)	imex:IM-25791|pubmed:16920955	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-15101254|imex:IM-25791-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171643.1|refseq:NP_001171644.1|refseq:NP_001171645.1|refseq:NP_443163.1|ensembl:ENSG00000162739(gene)|ensembl:ENST00000368057(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0045087"(innate immune response)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2IF7|reactome:R-HSA-198933	refseq:NP_444512.2|ensembl:ENSG00000198574(gene)|ensembl:ENST00000367929(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002366"(leukocyte activation involved in immune response)|go:"GO:0002717"(positive regulation of natural killer cell mediated immunity)|go:"GO:0005829"(cytosol)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|interpro:IPR000980(SH2 motif)|interpro:IPR035049|interpro:IPR036860|rcsb pdb:5KAZ|reactome:R-HSA-198933	-	-	-	figure legend:7Ai|comment:The Y13F mutant, only containing functional Y2, coimmunoprecipitated EAT-2, but not SAP.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-nkl)|taxid:9606(Homo sapiens)	-	2017/05/09	2017/06/13	rogid:rUujUH968ooEkRgUiIeCBZbsjCs9606	rogid:sbsE/jcSEsUrt8tK/EDz33pQqNQ9606	rigid:/NFxC8p0ikdhNPlFIU3x0OCFf64	false	mutation:274-274,309-309	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O60880	uniprotkb:Q96DU3	intact:EBI-6983382|ensembl:ENSP00000360181|uniprotkb:O95386|uniprotkb:Q6FGS6|uniprotkb:O95385|intact:MINT-113697|uniprotkb:A8MSW0|uniprotkb:O95384|uniprotkb:O95383|uniprotkb:Q9UNR0	intact:EBI-14058448|uniprotkb:A6NMW2|uniprotkb:B2R8X8|uniprotkb:Q14CF0|uniprotkb:Q5TAS4|uniprotkb:Q5TAS6|uniprotkb:Q5TAT3|uniprotkb:Q96DV0|ensembl:ENSP00000357036	psi-mi:sh21a_human(display_long)|uniprotkb:SH2D1A(gene name)|psi-mi:SH2D1A(display_short)|uniprotkb:DSHP(gene name synonym)|uniprotkb:SAP(gene name synonym)|uniprotkb:Signaling lymphocytic activation molecule-associated protein(gene name synonym)|uniprotkb:T-cell signal transduction molecule SAP(gene name synonym)|uniprotkb:Duncan disease SH2-protein(gene name synonym)	psi-mi:slaf6_human(display_long)|uniprotkb:KALI(gene name synonym)|uniprotkb:SLAMF6(gene name)|psi-mi:SLAMF6(display_short)|uniprotkb:Activating NK receptor(gene name synonym)|uniprotkb:NK-T-B-antigen(gene name synonym)|uniprotkb:UNQ6123/PRO20080(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Eissmann et al. (2006)	imex:IM-25791|pubmed:16920955	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-15101269|imex:IM-25791-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:1D4W|rcsb pdb:1KA6|rcsb pdb:1KA7|rcsb pdb:1M27|reactome:R-HSA-198933|ensembl:ENSG00000183918(gene)|ensembl:ENST00000371139(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006959"(humoral immune response)|go:"GO:0006968"(cellular defense response)|rcsb pdb:1D4T|go:"GO:0007267"(cell-cell signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR017289(SH2 protein 1A)|interpro:IPR035876|interpro:IPR036860|rcsb pdb:1D1Z|refseq:NP_001108409.1|refseq:NP_002342.1|dip:DIP-40768N	refseq:NP_001171643.1|refseq:NP_001171644.1|refseq:NP_001171645.1|refseq:NP_443163.1|ensembl:ENSG00000162739(gene)|ensembl:ENST00000368057(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0045087"(innate immune response)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2IF7|reactome:R-HSA-198933	-	comment:mint|function:Inhibitor of the SLAM self-association. Acts by blocking recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to a docking site in the slam cytoplasmic region|function:"Defects in SH2D1A are a cause of lymphoproliferative syndrome X-linked type 1 (XLP1) [MIM:308240]; also known as X-linked lymphoproliferative disease (XLPD) or Duncan disease. XLP is a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus (EBV). Symptoms include severe or fatal mononucleosis, acquired hypogammaglobulinemia, pancytopenia and malignant lymphoma"	-	figure legend:7Aii|comment:"When the second tyrosine was mutated (Y2F), the association of EAT-2 with NTB-A was lost, while SAP still associated."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-nkl)|taxid:9606(Homo sapiens)	-	2017/05/09	2017/06/13	rogid:tJL+FA6RUPeEknwUp85WT2p0+/c9606	rogid:rUujUH968ooEkRgUiIeCBZbsjCs9606	rigid:M9myN80LRe6lQBLe1EABCeU9gI8	false	-	mutation:285-285	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q96DU3	uniprotkb:O60880	intact:EBI-14058448|uniprotkb:A6NMW2|uniprotkb:B2R8X8|uniprotkb:Q14CF0|uniprotkb:Q5TAS4|uniprotkb:Q5TAS6|uniprotkb:Q5TAT3|uniprotkb:Q96DV0|ensembl:ENSP00000357036	intact:EBI-6983382|ensembl:ENSP00000360181|uniprotkb:O95386|uniprotkb:Q6FGS6|uniprotkb:O95385|intact:MINT-113697|uniprotkb:A8MSW0|uniprotkb:O95384|uniprotkb:O95383|uniprotkb:Q9UNR0	psi-mi:slaf6_human(display_long)|uniprotkb:KALI(gene name synonym)|uniprotkb:SLAMF6(gene name)|psi-mi:SLAMF6(display_short)|uniprotkb:Activating NK receptor(gene name synonym)|uniprotkb:NK-T-B-antigen(gene name synonym)|uniprotkb:UNQ6123/PRO20080(orf name)	psi-mi:sh21a_human(display_long)|uniprotkb:SH2D1A(gene name)|psi-mi:SH2D1A(display_short)|uniprotkb:DSHP(gene name synonym)|uniprotkb:SAP(gene name synonym)|uniprotkb:Signaling lymphocytic activation molecule-associated protein(gene name synonym)|uniprotkb:T-cell signal transduction molecule SAP(gene name synonym)|uniprotkb:Duncan disease SH2-protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Eissmann et al. (2006)	imex:IM-25791|pubmed:16920955	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-15183250|imex:IM-25791-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171643.1|refseq:NP_001171644.1|refseq:NP_001171645.1|refseq:NP_443163.1|ensembl:ENSG00000162739(gene)|ensembl:ENST00000368057(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0045087"(innate immune response)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2IF7|reactome:R-HSA-198933	rcsb pdb:1D4W|rcsb pdb:1KA6|rcsb pdb:1KA7|rcsb pdb:1M27|reactome:R-HSA-198933|ensembl:ENSG00000183918(gene)|ensembl:ENST00000371139(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006959"(humoral immune response)|go:"GO:0006968"(cellular defense response)|rcsb pdb:1D4T|go:"GO:0007267"(cell-cell signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR017289(SH2 protein 1A)|interpro:IPR035876|interpro:IPR036860|rcsb pdb:1D1Z|refseq:NP_001108409.1|refseq:NP_002342.1|dip:DIP-40768N	-	-	comment:mint|function:Inhibitor of the SLAM self-association. Acts by blocking recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to a docking site in the slam cytoplasmic region|function:"Defects in SH2D1A are a cause of lymphoproliferative syndrome X-linked type 1 (XLP1) [MIM:308240]; also known as X-linked lymphoproliferative disease (XLPD) or Duncan disease. XLP is a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus (EBV). Symptoms include severe or fatal mononucleosis, acquired hypogammaglobulinemia, pancytopenia and malignant lymphoma"	figure legend:7A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-nkl)|taxid:9606(Homo sapiens)	-	2017/05/09	2017/06/20	rogid:rUujUH968ooEkRgUiIeCBZbsjCs9606	rogid:tJL+FA6RUPeEknwUp85WT2p0+/c9606	rigid:LARmFGm9FHhm6FEQgzDIMA9CErM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q96DU3	uniprotkb:O14796	intact:EBI-14058448|uniprotkb:A6NMW2|uniprotkb:B2R8X8|uniprotkb:Q14CF0|uniprotkb:Q5TAS4|uniprotkb:Q5TAS6|uniprotkb:Q5TAT3|uniprotkb:Q96DV0|ensembl:ENSP00000357036	intact:EBI-3923013|uniprotkb:Q8NI18|uniprotkb:B2RBN6|uniprotkb:Q969K9|uniprotkb:Q5T0L1|ensembl:ENSP00000356906	psi-mi:slaf6_human(display_long)|uniprotkb:KALI(gene name synonym)|uniprotkb:SLAMF6(gene name)|psi-mi:SLAMF6(display_short)|uniprotkb:Activating NK receptor(gene name synonym)|uniprotkb:NK-T-B-antigen(gene name synonym)|uniprotkb:UNQ6123/PRO20080(orf name)	psi-mi:sh21b_human(display_long)|uniprotkb:SH2D1B(gene name)|psi-mi:SH2D1B(display_short)|uniprotkb:EAT2(gene name synonym)|uniprotkb:EWS/FLI1-activated transcript 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Eissmann et al. (2006)	imex:IM-25791|pubmed:16920955	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-15183250|imex:IM-25791-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171643.1|refseq:NP_001171644.1|refseq:NP_001171645.1|refseq:NP_443163.1|ensembl:ENSG00000162739(gene)|ensembl:ENST00000368057(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0045087"(innate immune response)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2IF7|reactome:R-HSA-198933	refseq:NP_444512.2|ensembl:ENSG00000198574(gene)|ensembl:ENST00000367929(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002366"(leukocyte activation involved in immune response)|go:"GO:0002717"(positive regulation of natural killer cell mediated immunity)|go:"GO:0005829"(cytosol)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|interpro:IPR000980(SH2 motif)|interpro:IPR035049|interpro:IPR036860|rcsb pdb:5KAZ|reactome:R-HSA-198933	-	-	-	figure legend:7A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-nkl)|taxid:9606(Homo sapiens)	-	2017/05/09	2017/06/20	rogid:rUujUH968ooEkRgUiIeCBZbsjCs9606	rogid:sbsE/jcSEsUrt8tK/EDz33pQqNQ9606	rigid:LARmFGm9FHhm6FEQgzDIMA9CErM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)