#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q00560	uniprotkb:O35718	intact:EBI-3862992|intact:EBI-15596000|uniprotkb:G5E8D2|ensembl:ENSMUSP00000064205|ensembl:ENSMUSP00000138836|ensembl:ENSMUSP00000139227	intact:EBI-2659360|uniprotkb:Q3U7X5|uniprotkb:P97803|ensembl:ENSMUSP00000059129	psi-mi:il6rb_mouse(display_long)|uniprotkb:Il6st(gene name)|psi-mi:Il6st(display_short)|uniprotkb:Interleukin-6 signal transducer(gene name synonym)|uniprotkb:Membrane glycoprotein 130(gene name synonym)|uniprotkb:Oncostatin-M receptor subunit alpha(gene name synonym)	psi-mi:socs3_mouse(display_long)|uniprotkb:Cytokine-inducible SH2 protein 3(gene name synonym)|uniprotkb:Protein EF-10(gene name synonym)|uniprotkb:Cis3(gene name synonym)|uniprotkb:Cish3(gene name synonym)|uniprotkb:Socs3(gene name)|psi-mi:Socs3(display_short)	psi-mi:"MI:0114"(x-ray crystallography)	Bergamin et al. (2006)	pubmed:16905102|doi:10.1016/j.str.2006.06.011|imex:IM-8457	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15596067|imex:IM-8457-1|dip:DIP-57147E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034690.3|dip:DIP-5782N|ensembl:ENSMUSG00000021756(gene)|ensembl:ENSMUST00000070731(transcript)|ensembl:ENSMUST00000183663(transcript)|ensembl:ENSMUST00000184311(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004897"(ciliary neurotrophic factor receptor activity)|go:"GO:0004915"(interleukin-6 receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0004924"(oncostatin-M receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005138"(interleukin-6 receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005896"(interleukin-6 receptor complex)|go:"GO:0005900"(oncostatin-M receptor complex)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0006642"(triglyceride mobilization)|go:"GO:0007165"(signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008593"(regulation of Notch signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0019981"(interleukin-6 binding)|go:"GO:0030425"(dendrite)|go:"GO:0032809"(neuronal cell body membrane)|go:"GO:0034097"(response to cytokine)|go:"GO:0038154"(interleukin-11-mediated signaling pathway)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0044297"(cell body)|go:"GO:0045121"(membrane raft)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0048861"(leukemia inhibitory factor signaling pathway)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0060576"(intestinal epithelial cell development)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070104"(negative regulation of interleukin-6-mediated signaling pathway)|go:"GO:0070106"(interleukin-27-mediated signaling pathway)|go:"GO:0070110"(ciliary neurotrophic factor receptor complex)|go:"GO:0070120"(ciliary neurotrophic factor-mediated signaling pathway)|go:"GO:0097110"(scaffold protein binding)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR010457(Immunoglobulin C2-set-like, ligand-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015321(Interleukin-6 receptor alpha chain, binding)|interpro:IPR036116|mint:Q00560|rcsb pdb:2BBU|rcsb pdb:2HMH|rcsb pdb:4GL9|rcsb pdb:6C5X|reactome:R-MMU-1059683|reactome:R-MMU-110056|reactome:R-MMU-112411|reactome:R-MMU-6788467|reactome:R-MMU-8984722|reactome:R-MMU-9020956|go:"GO:0042102"(positive regulation of T cell proliferation)	refseq:XP_011247009.1|refseq:NP_031733.1|ensembl:ENSMUSG00000053113(gene)|ensembl:ENSMUST00000054002(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0007165"(signal transduction)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0060707"(trophoblast giant cell differentiation)|go:"GO:0060708"(spongiotrophoblast differentiation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR028414|interpro:IPR035863|interpro:IPR036036|interpro:IPR036860|mint:O35718|rcsb pdb:2BBU|rcsb pdb:2HMH|rcsb pdb:2JZ3|rcsb pdb:4GL9|reactome:R-MMU-1059683|reactome:R-MMU-877300|reactome:R-MMU-877312|reactome:R-MMU-8849474|reactome:R-MMU-8951664|reactome:R-MMU-909733|reactome:R-MMU-9705462|reactome:R-MMU-983168|dip:DIP-29137N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/11	rogid:DE0EsnNO+FvIfikpCy6T+Ma372Y10090	rogid:SFk8FM1xo7SkodsiFXZYzTbLrYg10090	rigid:pqmSwwgWt+GARL/2+XlLc/jWszs	false	sufficient binding region:753-763	sufficient binding region:154-185,15-130	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q00560	uniprotkb:O35718	intact:EBI-3862992|intact:EBI-15596000|uniprotkb:G5E8D2|ensembl:ENSMUSP00000064205|ensembl:ENSMUSP00000138836|ensembl:ENSMUSP00000139227	intact:EBI-2659360|uniprotkb:Q3U7X5|uniprotkb:P97803|ensembl:ENSMUSP00000059129	psi-mi:il6rb_mouse(display_long)|uniprotkb:Il6st(gene name)|psi-mi:Il6st(display_short)|uniprotkb:Interleukin-6 signal transducer(gene name synonym)|uniprotkb:Membrane glycoprotein 130(gene name synonym)|uniprotkb:Oncostatin-M receptor subunit alpha(gene name synonym)	psi-mi:socs3_mouse(display_long)|uniprotkb:Cytokine-inducible SH2 protein 3(gene name synonym)|uniprotkb:Protein EF-10(gene name synonym)|uniprotkb:Cis3(gene name synonym)|uniprotkb:Cish3(gene name synonym)|uniprotkb:Socs3(gene name)|psi-mi:Socs3(display_short)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Bergamin et al. (2006)	pubmed:16905102|doi:10.1016/j.str.2006.06.011|imex:IM-8457	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15596089|imex:IM-8457-2|dip:DIP-57147E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034690.3|dip:DIP-5782N|ensembl:ENSMUSG00000021756(gene)|ensembl:ENSMUST00000070731(transcript)|ensembl:ENSMUST00000183663(transcript)|ensembl:ENSMUST00000184311(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004897"(ciliary neurotrophic factor receptor activity)|go:"GO:0004915"(interleukin-6 receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0004924"(oncostatin-M receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005138"(interleukin-6 receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005896"(interleukin-6 receptor complex)|go:"GO:0005900"(oncostatin-M receptor complex)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0006642"(triglyceride mobilization)|go:"GO:0007165"(signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008593"(regulation of Notch signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0019981"(interleukin-6 binding)|go:"GO:0030425"(dendrite)|go:"GO:0032809"(neuronal cell body membrane)|go:"GO:0034097"(response to cytokine)|go:"GO:0038154"(interleukin-11-mediated signaling pathway)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0044297"(cell body)|go:"GO:0045121"(membrane raft)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0048861"(leukemia inhibitory factor signaling pathway)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0060576"(intestinal epithelial cell development)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070104"(negative regulation of interleukin-6-mediated signaling pathway)|go:"GO:0070106"(interleukin-27-mediated signaling pathway)|go:"GO:0070110"(ciliary neurotrophic factor receptor complex)|go:"GO:0070120"(ciliary neurotrophic factor-mediated signaling pathway)|go:"GO:0097110"(scaffold protein binding)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR010457(Immunoglobulin C2-set-like, ligand-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015321(Interleukin-6 receptor alpha chain, binding)|interpro:IPR036116|mint:Q00560|rcsb pdb:2BBU|rcsb pdb:2HMH|rcsb pdb:4GL9|rcsb pdb:6C5X|reactome:R-MMU-1059683|reactome:R-MMU-110056|reactome:R-MMU-112411|reactome:R-MMU-6788467|reactome:R-MMU-8984722|reactome:R-MMU-9020956|go:"GO:0042102"(positive regulation of T cell proliferation)	refseq:XP_011247009.1|refseq:NP_031733.1|ensembl:ENSMUSG00000053113(gene)|ensembl:ENSMUST00000054002(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0007165"(signal transduction)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0060707"(trophoblast giant cell differentiation)|go:"GO:0060708"(spongiotrophoblast differentiation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR028414|interpro:IPR035863|interpro:IPR036036|interpro:IPR036860|mint:O35718|rcsb pdb:2BBU|rcsb pdb:2HMH|rcsb pdb:2JZ3|rcsb pdb:4GL9|reactome:R-MMU-1059683|reactome:R-MMU-877300|reactome:R-MMU-877312|reactome:R-MMU-8849474|reactome:R-MMU-8951664|reactome:R-MMU-909733|reactome:R-MMU-9705462|reactome:R-MMU-983168|dip:DIP-29137N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:6.8x10^-8(molar)	2017/08/05	2017/08/11	rogid:DE0EsnNO+FvIfikpCy6T+Ma372Y10090	rogid:SFk8FM1xo7SkodsiFXZYzTbLrYg10090	rigid:pqmSwwgWt+GARL/2+XlLc/jWszs	false	sufficient binding region:753-763	sufficient binding region:154-185,15-130	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)