#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P40016 uniprotkb:O94742 intact:EBI-15927|uniprotkb:D3DLS0|ensemblfungi:YER021W intact:EBI-31337|uniprotkb:D6VSZ2|ensemblfungi:YDR363W-A psi-mi:rpn3_yeast(display_long)|uniprotkb:RPN3(gene name)|psi-mi:RPN3(display_short)|uniprotkb:SUN2(gene name synonym)|uniprotkb:YER021W(locus name) psi-mi:sem1_yeast(display_long)|uniprotkb:SEM1(gene name)|psi-mi:SEM1(display_short)|uniprotkb:DSH1(gene name synonym)|uniprotkb:YDR363W-A(locus name) psi-mi:"MI:0069"(mass spectrometry studies of complexes) Sharon et al. (2006) doi:10.1371/journal.pbio.0040267|pubmed:16869714|imex:IM-8531 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15593671|imex:IM-8531-6|dip:DIP-57216E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_010938.1|sgd:S000000823|ensemblfungi:YER021W(gene)|ensemblfungi:YER021W_mRNA(transcript)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0042176"(regulation of protein catabolic process)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR013586(26S proteasome regulatory subunit, C-terminal)|interpro:IPR035267|interpro:IPR036390|rcsb pdb:3J47|rcsb pdb:3JCK|rcsb pdb:3JCO|rcsb pdb:3JCP|rcsb pdb:4CR2|rcsb pdb:4CR3|rcsb pdb:4CR4|rcsb pdb:5A5B|rcsb pdb:5MPB|rcsb pdb:5MPC|rcsb pdb:5MPD|rcsb pdb:5MPE|rcsb pdb:5WVI|rcsb pdb:5WVK|rcsb pdb:6FVT|rcsb pdb:6FVU|rcsb pdb:6FVV|rcsb pdb:6FVW|rcsb pdb:6FVX|rcsb pdb:6FVY|rcsb pdb:6J2C|rcsb pdb:6J2N|rcsb pdb:6J2Q|rcsb pdb:6J2X|rcsb pdb:6J30|reactome:R-SCE-1236978|reactome:R-SCE-174113|reactome:R-SCE-5668541|reactome:R-SCE-5687128|reactome:R-SCE-5689880|reactome:R-SCE-6798695|reactome:R-SCE-68949|reactome:R-SCE-69017|reactome:R-SCE-69601|reactome:R-SCE-75815|reactome:R-SCE-8854050|reactome:R-SCE-8948751|reactome:R-SCE-983168|dip:DIP-1322N|mint:P40016 refseq:NP_010651.3|sgd:S000007235|dip:DIP-8754N|mint:O94742|ensemblfungi:YDR363W-A(gene)|ensemblfungi:YDR363W-A_mRNA(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0005829"(cytosol)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0030447"(filamentous growth)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0035753"(maintenance of DNA trinucleotide repeats)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043248"(proteasome assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070390"(transcription export complex 2)|go:"GO:0072742"(SAGA complex localization to transcription regulatory region)|interpro:IPR007834(DSS1/SEM1)|rcsb pdb:3JCK|rcsb pdb:3JCO|rcsb pdb:3JCP|rcsb pdb:3T5V|rcsb pdb:4CR2|rcsb pdb:4CR3|rcsb pdb:4CR4|rcsb pdb:4TRQ|rcsb pdb:5A5B|rcsb pdb:5G5P|rcsb pdb:5L3T|rcsb pdb:5MPB|rcsb pdb:5MPC|rcsb pdb:5MPD|rcsb pdb:5MPE|rcsb pdb:5UBP|rcsb pdb:5WVI|rcsb pdb:5WVK|rcsb pdb:6FVT|rcsb pdb:6FVU|rcsb pdb:6FVV|rcsb pdb:6FVW|rcsb pdb:6FVX|rcsb pdb:6FVY|rcsb pdb:6J2C|rcsb pdb:6J2N|rcsb pdb:6J2Q|rcsb pdb:6J2X|rcsb pdb:6J30 psi-mi:"MI:0465"(dip) crc64:B08B58663DDA85DC crc64:B66B578ABB01E672 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/05 2017/08/10 rogid:pXkyoZKr0rI5usi19R+TvS4hSso559292 rogid:jW26dMSkSwiSL4WsgtoWcg98j9A559292 rigid:/yYHozqtKTK3zX2uJs3FOwHMqHc false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O94742 uniprotkb:Q06103 intact:EBI-31337|uniprotkb:D6VSZ2|ensemblfungi:YDR363W-A intact:EBI-15940|uniprotkb:D6W4A6|uniprotkb:E9P8W9|ensemblfungi:YPR108W psi-mi:sem1_yeast(display_long)|uniprotkb:SEM1(gene name)|psi-mi:SEM1(display_short)|uniprotkb:DSH1(gene name synonym)|uniprotkb:YDR363W-A(locus name) psi-mi:rpn7_yeast(display_long)|uniprotkb:RPN7(gene name)|psi-mi:RPN7(display_short)|uniprotkb:P8283.8(orf name)|uniprotkb:YPR108W(locus name) psi-mi:"MI:0069"(mass spectrometry studies of complexes) Sharon et al. (2006) doi:10.1371/journal.pbio.0040267|pubmed:16869714|imex:IM-8531 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15593654|imex:IM-8531-5|dip:DIP-57215E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_010651.3|sgd:S000007235|dip:DIP-8754N|mint:O94742|ensemblfungi:YDR363W-A(gene)|ensemblfungi:YDR363W-A_mRNA(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0005829"(cytosol)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0030447"(filamentous growth)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0035753"(maintenance of DNA trinucleotide repeats)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043248"(proteasome assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070390"(transcription export complex 2)|go:"GO:0072742"(SAGA complex localization to transcription regulatory region)|interpro:IPR007834(DSS1/SEM1)|rcsb pdb:3JCK|rcsb pdb:3JCO|rcsb pdb:3JCP|rcsb pdb:3T5V|rcsb pdb:4CR2|rcsb pdb:4CR3|rcsb pdb:4CR4|rcsb pdb:4TRQ|rcsb pdb:5A5B|rcsb pdb:5G5P|rcsb pdb:5L3T|rcsb pdb:5MPB|rcsb pdb:5MPC|rcsb pdb:5MPD|rcsb pdb:5MPE|rcsb pdb:5UBP|rcsb pdb:5WVI|rcsb pdb:5WVK|rcsb pdb:6FVT|rcsb pdb:6FVU|rcsb pdb:6FVV|rcsb pdb:6FVW|rcsb pdb:6FVX|rcsb pdb:6FVY|rcsb pdb:6J2C|rcsb pdb:6J2N|rcsb pdb:6J2Q|rcsb pdb:6J2X|rcsb pdb:6J30 refseq:NP_015433.1|sgd:S000006312|ensemblfungi:YPR108W(gene)|ensemblfungi:YPR108W_mRNA(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005634"(nucleus)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019585|interpro:IPR019734|interpro:IPR035268|interpro:IPR036390|rcsb pdb:5MPB|rcsb pdb:5MPC|rcsb pdb:5MPD|rcsb pdb:5MPE|rcsb pdb:5WVI|rcsb pdb:5WVK|rcsb pdb:6FVT|rcsb pdb:6FVU|rcsb pdb:6FVV|rcsb pdb:6FVW|rcsb pdb:6FVX|rcsb pdb:6FVY|rcsb pdb:6J2C|rcsb pdb:6J2N|rcsb pdb:6J2Q|rcsb pdb:6J2X|rcsb pdb:6J30|reactome:R-SCE-1236978|reactome:R-SCE-174113|rcsb pdb:3J47|reactome:R-SCE-5668541|reactome:R-SCE-5687128|reactome:R-SCE-5689880|reactome:R-SCE-6798695|reactome:R-SCE-68949|reactome:R-SCE-69017|reactome:R-SCE-69601|reactome:R-SCE-75815|rcsb pdb:3JCK|reactome:R-SCE-8854050|reactome:R-SCE-8948751|reactome:R-SCE-983168|rcsb pdb:3JCO|rcsb pdb:3JCP|rcsb pdb:4CR2|rcsb pdb:4CR3|rcsb pdb:4CR4|rcsb pdb:5A5B|dip:DIP-2880N|mint:Q06103 psi-mi:"MI:0465"(dip) crc64:B66B578ABB01E672 crc64:B21B66CD818E636D full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/05 2017/08/10 rogid:jW26dMSkSwiSL4WsgtoWcg98j9A559292 rogid:RVj0KoFtiJVk9oF3cYIftSVLejc559292 rigid:gzfLO8AG6d5Am1vX3mgDpngALMc false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q12250 uniprotkb:P40016 intact:EBI-15935|uniprotkb:D6VRK1|ensemblfungi:YDL147W intact:EBI-15927|uniprotkb:D3DLS0|ensemblfungi:YER021W psi-mi:rpn5_yeast(display_long)|uniprotkb:RPN5(gene name)|psi-mi:RPN5(display_short)|uniprotkb:NAS5(gene name synonym)|uniprotkb:YDL147W(locus name)|uniprotkb:D1572(orf name)|uniprotkb:Proteasome non-ATPase subunit 5(gene name synonym) psi-mi:rpn3_yeast(display_long)|uniprotkb:RPN3(gene name)|psi-mi:RPN3(display_short)|uniprotkb:SUN2(gene name synonym)|uniprotkb:YER021W(locus name) psi-mi:"MI:0069"(mass spectrometry studies of complexes) Sharon et al. (2006) doi:10.1371/journal.pbio.0040267|pubmed:16869714|imex:IM-8531 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15593688|imex:IM-8531-3|dip:DIP-16479E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_010134.1|sgd:S000002306|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR035297|interpro:IPR036388|interpro:IPR036390|interpro:IPR040134|interpro:IPR040896|rcsb pdb:3J47|rcsb pdb:3JCK|rcsb pdb:3JCO|rcsb pdb:3JCP|rcsb pdb:4CR2|rcsb pdb:4CR3|rcsb pdb:4CR4|rcsb pdb:5A5B|rcsb pdb:5MPB|rcsb pdb:5MPC|rcsb pdb:5MPD|rcsb pdb:5MPE|rcsb pdb:5WVI|rcsb pdb:5WVK|rcsb pdb:5ZMR|rcsb pdb:6FVT|rcsb pdb:6FVU|rcsb pdb:6FVV|rcsb pdb:6FVW|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|rcsb pdb:6FVX|ensemblfungi:YDL147W(gene)|ensemblfungi:YDL147W_mRNA(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0000502"(proteasome complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0031595"(nuclear proteasome complex)|go:"GO:0034515"(proteasome storage granule)|rcsb pdb:6J2C|rcsb pdb:6FVY|rcsb pdb:6J2N|rcsb pdb:6J2Q|rcsb pdb:6J2X|rcsb pdb:6J30|reactome:R-SCE-1236978|reactome:R-SCE-174113|reactome:R-SCE-5668541|reactome:R-SCE-5687128|reactome:R-SCE-5689880|reactome:R-SCE-6798695|reactome:R-SCE-68949|reactome:R-SCE-69017|reactome:R-SCE-69601|reactome:R-SCE-75815|reactome:R-SCE-8854050|reactome:R-SCE-8948751|reactome:R-SCE-983168|dip:DIP-1578N|mint:Q12250 refseq:NP_010938.1|sgd:S000000823|ensemblfungi:YER021W(gene)|ensemblfungi:YER021W_mRNA(transcript)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0042176"(regulation of protein catabolic process)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR013586(26S proteasome regulatory subunit, C-terminal)|interpro:IPR035267|interpro:IPR036390|rcsb pdb:3J47|rcsb pdb:3JCK|rcsb pdb:3JCO|rcsb pdb:3JCP|rcsb pdb:4CR2|rcsb pdb:4CR3|rcsb pdb:4CR4|rcsb pdb:5A5B|rcsb pdb:5MPB|rcsb pdb:5MPC|rcsb pdb:5MPD|rcsb pdb:5MPE|rcsb pdb:5WVI|rcsb pdb:5WVK|rcsb pdb:6FVT|rcsb pdb:6FVU|rcsb pdb:6FVV|rcsb pdb:6FVW|rcsb pdb:6FVX|rcsb pdb:6FVY|rcsb pdb:6J2C|rcsb pdb:6J2N|rcsb pdb:6J2Q|rcsb pdb:6J2X|rcsb pdb:6J30|reactome:R-SCE-1236978|reactome:R-SCE-174113|reactome:R-SCE-5668541|reactome:R-SCE-5687128|reactome:R-SCE-5689880|reactome:R-SCE-6798695|reactome:R-SCE-68949|reactome:R-SCE-69017|reactome:R-SCE-69601|reactome:R-SCE-75815|reactome:R-SCE-8854050|reactome:R-SCE-8948751|reactome:R-SCE-983168|dip:DIP-1322N|mint:P40016 psi-mi:"MI:0465"(dip) crc64:E5DC7F8E6AE27736 crc64:B08B58663DDA85DC full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/05 2017/08/10 rogid:DaeRxapE6TgoZG4emWRb3y12Vfc559292 rogid:pXkyoZKr0rI5usi19R+TvS4hSso559292 rigid:GfLVvr70AStwCWNkiEdjrEiHe+o false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P40016 uniprotkb:Q12250 intact:EBI-15927|uniprotkb:D3DLS0|ensemblfungi:YER021W intact:EBI-15935|uniprotkb:D6VRK1|ensemblfungi:YDL147W psi-mi:rpn3_yeast(display_long)|uniprotkb:RPN3(gene name)|psi-mi:RPN3(display_short)|uniprotkb:SUN2(gene name synonym)|uniprotkb:YER021W(locus name) psi-mi:rpn5_yeast(display_long)|uniprotkb:RPN5(gene name)|psi-mi:RPN5(display_short)|uniprotkb:NAS5(gene name synonym)|uniprotkb:YDL147W(locus name)|uniprotkb:D1572(orf name)|uniprotkb:Proteasome non-ATPase subunit 5(gene name synonym) psi-mi:"MI:0069"(mass spectrometry studies of complexes) Sharon et al. (2006) doi:10.1371/journal.pbio.0040267|pubmed:16869714|imex:IM-8531 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15593705|imex:IM-8531-2|dip:DIP-57217E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_010938.1|sgd:S000000823|ensemblfungi:YER021W(gene)|ensemblfungi:YER021W_mRNA(transcript)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0042176"(regulation of protein catabolic process)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR013586(26S proteasome regulatory subunit, C-terminal)|interpro:IPR035267|interpro:IPR036390|rcsb pdb:3J47|rcsb pdb:3JCK|rcsb pdb:3JCO|rcsb pdb:3JCP|rcsb pdb:4CR2|rcsb pdb:4CR3|rcsb pdb:4CR4|rcsb pdb:5A5B|rcsb pdb:5MPB|rcsb pdb:5MPC|rcsb pdb:5MPD|rcsb pdb:5MPE|rcsb pdb:5WVI|rcsb pdb:5WVK|rcsb pdb:6FVT|rcsb pdb:6FVU|rcsb pdb:6FVV|rcsb pdb:6FVW|rcsb pdb:6FVX|rcsb pdb:6FVY|rcsb pdb:6J2C|rcsb pdb:6J2N|rcsb pdb:6J2Q|rcsb pdb:6J2X|rcsb pdb:6J30|reactome:R-SCE-1236978|reactome:R-SCE-174113|reactome:R-SCE-5668541|reactome:R-SCE-5687128|reactome:R-SCE-5689880|reactome:R-SCE-6798695|reactome:R-SCE-68949|reactome:R-SCE-69017|reactome:R-SCE-69601|reactome:R-SCE-75815|reactome:R-SCE-8854050|reactome:R-SCE-8948751|reactome:R-SCE-983168|dip:DIP-1322N|mint:P40016 refseq:NP_010134.1|sgd:S000002306|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR035297|interpro:IPR036388|interpro:IPR036390|interpro:IPR040134|interpro:IPR040896|rcsb pdb:3J47|rcsb pdb:3JCK|rcsb pdb:3JCO|rcsb pdb:3JCP|rcsb pdb:4CR2|rcsb pdb:4CR3|rcsb pdb:4CR4|rcsb pdb:5A5B|rcsb pdb:5MPB|rcsb pdb:5MPC|rcsb pdb:5MPD|rcsb pdb:5MPE|rcsb pdb:5WVI|rcsb pdb:5WVK|rcsb pdb:5ZMR|rcsb pdb:6FVT|rcsb pdb:6FVU|rcsb pdb:6FVV|rcsb pdb:6FVW|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|rcsb pdb:6FVX|ensemblfungi:YDL147W(gene)|ensemblfungi:YDL147W_mRNA(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0000502"(proteasome complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0031595"(nuclear proteasome complex)|go:"GO:0034515"(proteasome storage granule)|rcsb pdb:6J2C|rcsb pdb:6FVY|rcsb pdb:6J2N|rcsb pdb:6J2Q|rcsb pdb:6J2X|rcsb pdb:6J30|reactome:R-SCE-1236978|reactome:R-SCE-174113|reactome:R-SCE-5668541|reactome:R-SCE-5687128|reactome:R-SCE-5689880|reactome:R-SCE-6798695|reactome:R-SCE-68949|reactome:R-SCE-69017|reactome:R-SCE-69601|reactome:R-SCE-75815|reactome:R-SCE-8854050|reactome:R-SCE-8948751|reactome:R-SCE-983168|dip:DIP-1578N|mint:Q12250 psi-mi:"MI:0465"(dip) crc64:B08B58663DDA85DC crc64:E5DC7F8E6AE27736 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/05 2017/08/10 rogid:pXkyoZKr0rI5usi19R+TvS4hSso559292 rogid:DaeRxapE6TgoZG4emWRb3y12Vfc559292 rigid:zd0p3ZobgFIyxI91iYdoaTJaLp4 false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P40016 uniprotkb:Q08723 intact:EBI-15927|uniprotkb:D3DLS0|ensemblfungi:YER021W intact:EBI-36176|uniprotkb:Q6Q5I7|uniprotkb:D6W2W2|ensemblfungi:YOR261C psi-mi:rpn3_yeast(display_long)|uniprotkb:RPN3(gene name)|psi-mi:RPN3(display_short)|uniprotkb:SUN2(gene name synonym)|uniprotkb:YER021W(locus name) psi-mi:rpn8_yeast(display_long)|uniprotkb:RPN8(gene name)|psi-mi:RPN8(display_short)|uniprotkb:O5360(orf name)|uniprotkb:YOR261C(locus name) psi-mi:"MI:0069"(mass spectrometry studies of complexes) Sharon et al. (2006) doi:10.1371/journal.pbio.0040267|pubmed:16869714|imex:IM-8531 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15593705|imex:IM-8531-2|dip:DIP-57217E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_010938.1|sgd:S000000823|ensemblfungi:YER021W(gene)|ensemblfungi:YER021W_mRNA(transcript)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0042176"(regulation of protein catabolic process)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR013586(26S proteasome regulatory subunit, C-terminal)|interpro:IPR035267|interpro:IPR036390|rcsb pdb:3J47|rcsb pdb:3JCK|rcsb pdb:3JCO|rcsb pdb:3JCP|rcsb pdb:4CR2|rcsb pdb:4CR3|rcsb pdb:4CR4|rcsb pdb:5A5B|rcsb pdb:5MPB|rcsb pdb:5MPC|rcsb pdb:5MPD|rcsb pdb:5MPE|rcsb pdb:5WVI|rcsb pdb:5WVK|rcsb pdb:6FVT|rcsb pdb:6FVU|rcsb pdb:6FVV|rcsb pdb:6FVW|rcsb pdb:6FVX|rcsb pdb:6FVY|rcsb pdb:6J2C|rcsb pdb:6J2N|rcsb pdb:6J2Q|rcsb pdb:6J2X|rcsb pdb:6J30|reactome:R-SCE-1236978|reactome:R-SCE-174113|reactome:R-SCE-5668541|reactome:R-SCE-5687128|reactome:R-SCE-5689880|reactome:R-SCE-6798695|reactome:R-SCE-68949|reactome:R-SCE-69017|reactome:R-SCE-69601|reactome:R-SCE-75815|reactome:R-SCE-8854050|reactome:R-SCE-8948751|reactome:R-SCE-983168|dip:DIP-1322N|mint:P40016 sgd:S000005787|refseq:NP_014904.3|mint:Q08723|dip:DIP-1574N|ensemblfungi:YOR261C(gene)|ensemblfungi:YOR261C_mRNA(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070122"(isopeptidase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR024969|interpro:IPR033858|interpro:IPR037518|rcsb pdb:3J47|rcsb pdb:3JCK|rcsb pdb:3JCO|rcsb pdb:3JCP|rcsb pdb:4CR2|rcsb pdb:4CR3|rcsb pdb:4CR4|rcsb pdb:4O8X|rcsb pdb:4O8Y|rcsb pdb:4OCL|rcsb pdb:4OCM|rcsb pdb:4OCN|rcsb pdb:4OWP|rcsb pdb:5A5B|rcsb pdb:5MPB|rcsb pdb:5MPC|rcsb pdb:5MPD|rcsb pdb:5MPE|rcsb pdb:5U4P|rcsb pdb:5W83|rcsb pdb:5WVI|rcsb pdb:5WVK|rcsb pdb:6FVT|rcsb pdb:6FVU|rcsb pdb:6FVV|rcsb pdb:6FVW|rcsb pdb:6FVX|rcsb pdb:6FVY|rcsb pdb:6J2C|rcsb pdb:6J2N|rcsb pdb:6J2Q|rcsb pdb:6J2X|rcsb pdb:6J30|reactome:R-SCE-1236978|reactome:R-SCE-174113|reactome:R-SCE-5668541|reactome:R-SCE-5687128|reactome:R-SCE-5689880|reactome:R-SCE-6798695|reactome:R-SCE-68949|reactome:R-SCE-69017|reactome:R-SCE-69601|reactome:R-SCE-75815|reactome:R-SCE-8854050|reactome:R-SCE-8948751|reactome:R-SCE-983168 psi-mi:"MI:0465"(dip) crc64:B08B58663DDA85DC crc64:6EE6009545A3D0EF full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/05 2017/08/10 rogid:pXkyoZKr0rI5usi19R+TvS4hSso559292 rogid:kvJ/LyyQGKi5JTh4Fek1kh70jOU559292 rigid:zd0p3ZobgFIyxI91iYdoaTJaLp4 false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q12250 uniprotkb:Q12377 intact:EBI-15935|uniprotkb:D6VRK1|ensemblfungi:YDL147W intact:EBI-308|uniprotkb:D6VRQ3|ensemblfungi:YDL097C psi-mi:rpn5_yeast(display_long)|uniprotkb:RPN5(gene name)|psi-mi:RPN5(display_short)|uniprotkb:NAS5(gene name synonym)|uniprotkb:YDL147W(locus name)|uniprotkb:D1572(orf name)|uniprotkb:Proteasome non-ATPase subunit 5(gene name synonym) psi-mi:rpn6_yeast(display_long)|uniprotkb:RPN6(gene name)|psi-mi:RPN6(display_short)|uniprotkb:NAS4(gene name synonym)|uniprotkb:YDL097C(locus name)|uniprotkb:D2381(orf name)|uniprotkb:Proteasome non-ATPase subunit 4(gene name synonym) psi-mi:"MI:0069"(mass spectrometry studies of complexes) Sharon et al. (2006) doi:10.1371/journal.pbio.0040267|pubmed:16869714|imex:IM-8531 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15593742|imex:IM-8531-7|dip:DIP-57219E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_010134.1|sgd:S000002306|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR035297|interpro:IPR036388|interpro:IPR036390|interpro:IPR040134|interpro:IPR040896|rcsb pdb:3J47|rcsb pdb:3JCK|rcsb pdb:3JCO|rcsb pdb:3JCP|rcsb pdb:4CR2|rcsb pdb:4CR3|rcsb pdb:4CR4|rcsb pdb:5A5B|rcsb pdb:5MPB|rcsb pdb:5MPC|rcsb pdb:5MPD|rcsb pdb:5MPE|rcsb pdb:5WVI|rcsb pdb:5WVK|rcsb pdb:5ZMR|rcsb pdb:6FVT|rcsb pdb:6FVU|rcsb pdb:6FVV|rcsb pdb:6FVW|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|rcsb pdb:6FVX|ensemblfungi:YDL147W(gene)|ensemblfungi:YDL147W_mRNA(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0000502"(proteasome complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0031595"(nuclear proteasome complex)|go:"GO:0034515"(proteasome storage granule)|rcsb pdb:6J2C|rcsb pdb:6FVY|rcsb pdb:6J2N|rcsb pdb:6J2Q|rcsb pdb:6J2X|rcsb pdb:6J30|reactome:R-SCE-1236978|reactome:R-SCE-174113|reactome:R-SCE-5668541|reactome:R-SCE-5687128|reactome:R-SCE-5689880|reactome:R-SCE-6798695|reactome:R-SCE-68949|reactome:R-SCE-69017|reactome:R-SCE-69601|reactome:R-SCE-75815|reactome:R-SCE-8854050|reactome:R-SCE-8948751|reactome:R-SCE-983168|dip:DIP-1578N|mint:Q12250 refseq:NP_010186.1|sgd:S000002255|dip:DIP-1581N|mint:Q12377|ensemblfungi:YDL097C(gene)|ensemblfungi:YDL097C_mRNA(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0043248"(proteasome assembly)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR036390|interpro:IPR040773|interpro:IPR040780|rcsb pdb:3J47|rcsb pdb:3JCK|rcsb pdb:3JCO|rcsb pdb:3JCP|rcsb pdb:4CR2|rcsb pdb:4CR3|rcsb pdb:4CR4|rcsb pdb:5A5B|rcsb pdb:5MPB|rcsb pdb:5MPC|rcsb pdb:5MPD|rcsb pdb:5MPE|rcsb pdb:5WVI|rcsb pdb:5WVK|rcsb pdb:6FVT|rcsb pdb:6FVU|rcsb pdb:6FVV|rcsb pdb:6FVW|rcsb pdb:6FVX|rcsb pdb:6FVY|rcsb pdb:6J2C|rcsb pdb:6J2N|rcsb pdb:6J2Q|rcsb pdb:6J2X|rcsb pdb:6J30|reactome:R-SCE-1236978|reactome:R-SCE-174113|reactome:R-SCE-5668541|reactome:R-SCE-5687128|reactome:R-SCE-5689880|reactome:R-SCE-6798695|reactome:R-SCE-68949|reactome:R-SCE-69017|reactome:R-SCE-69601|reactome:R-SCE-75815|reactome:R-SCE-8854050|reactome:R-SCE-8948751|reactome:R-SCE-983168 psi-mi:"MI:0465"(dip) crc64:E5DC7F8E6AE27736 crc64:A8B1F7E6F73A4024 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/05 2017/08/10 rogid:DaeRxapE6TgoZG4emWRb3y12Vfc559292 rogid:Q7d0N0C4nR9dUZHh+zofzWAF/t8559292 rigid:BBJqYup6ke0mD/Xk1S1oKA1rObU false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q12250 uniprotkb:Q08723 intact:EBI-15935|uniprotkb:D6VRK1|ensemblfungi:YDL147W intact:EBI-36176|uniprotkb:Q6Q5I7|uniprotkb:D6W2W2|ensemblfungi:YOR261C psi-mi:rpn5_yeast(display_long)|uniprotkb:RPN5(gene name)|psi-mi:RPN5(display_short)|uniprotkb:NAS5(gene name synonym)|uniprotkb:YDL147W(locus name)|uniprotkb:D1572(orf name)|uniprotkb:Proteasome non-ATPase subunit 5(gene name synonym) psi-mi:rpn8_yeast(display_long)|uniprotkb:RPN8(gene name)|psi-mi:RPN8(display_short)|uniprotkb:O5360(orf name)|uniprotkb:YOR261C(locus name) psi-mi:"MI:0069"(mass spectrometry studies of complexes) Sharon et al. (2006) doi:10.1371/journal.pbio.0040267|pubmed:16869714|imex:IM-8531 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15593742|imex:IM-8531-7|dip:DIP-57219E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_010134.1|sgd:S000002306|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR035297|interpro:IPR036388|interpro:IPR036390|interpro:IPR040134|interpro:IPR040896|rcsb pdb:3J47|rcsb pdb:3JCK|rcsb pdb:3JCO|rcsb pdb:3JCP|rcsb pdb:4CR2|rcsb pdb:4CR3|rcsb pdb:4CR4|rcsb pdb:5A5B|rcsb pdb:5MPB|rcsb pdb:5MPC|rcsb pdb:5MPD|rcsb pdb:5MPE|rcsb pdb:5WVI|rcsb pdb:5WVK|rcsb pdb:5ZMR|rcsb pdb:6FVT|rcsb pdb:6FVU|rcsb pdb:6FVV|rcsb pdb:6FVW|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|rcsb pdb:6FVX|ensemblfungi:YDL147W(gene)|ensemblfungi:YDL147W_mRNA(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0000502"(proteasome complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0031595"(nuclear proteasome complex)|go:"GO:0034515"(proteasome storage granule)|rcsb pdb:6J2C|rcsb pdb:6FVY|rcsb pdb:6J2N|rcsb pdb:6J2Q|rcsb pdb:6J2X|rcsb pdb:6J30|reactome:R-SCE-1236978|reactome:R-SCE-174113|reactome:R-SCE-5668541|reactome:R-SCE-5687128|reactome:R-SCE-5689880|reactome:R-SCE-6798695|reactome:R-SCE-68949|reactome:R-SCE-69017|reactome:R-SCE-69601|reactome:R-SCE-75815|reactome:R-SCE-8854050|reactome:R-SCE-8948751|reactome:R-SCE-983168|dip:DIP-1578N|mint:Q12250 sgd:S000005787|refseq:NP_014904.3|mint:Q08723|dip:DIP-1574N|ensemblfungi:YOR261C(gene)|ensemblfungi:YOR261C_mRNA(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070122"(isopeptidase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR024969|interpro:IPR033858|interpro:IPR037518|rcsb pdb:3J47|rcsb pdb:3JCK|rcsb pdb:3JCO|rcsb pdb:3JCP|rcsb pdb:4CR2|rcsb pdb:4CR3|rcsb pdb:4CR4|rcsb pdb:4O8X|rcsb pdb:4O8Y|rcsb pdb:4OCL|rcsb pdb:4OCM|rcsb pdb:4OCN|rcsb pdb:4OWP|rcsb pdb:5A5B|rcsb pdb:5MPB|rcsb pdb:5MPC|rcsb pdb:5MPD|rcsb pdb:5MPE|rcsb pdb:5U4P|rcsb pdb:5W83|rcsb pdb:5WVI|rcsb pdb:5WVK|rcsb pdb:6FVT|rcsb pdb:6FVU|rcsb pdb:6FVV|rcsb pdb:6FVW|rcsb pdb:6FVX|rcsb pdb:6FVY|rcsb pdb:6J2C|rcsb pdb:6J2N|rcsb pdb:6J2Q|rcsb pdb:6J2X|rcsb pdb:6J30|reactome:R-SCE-1236978|reactome:R-SCE-174113|reactome:R-SCE-5668541|reactome:R-SCE-5687128|reactome:R-SCE-5689880|reactome:R-SCE-6798695|reactome:R-SCE-68949|reactome:R-SCE-69017|reactome:R-SCE-69601|reactome:R-SCE-75815|reactome:R-SCE-8854050|reactome:R-SCE-8948751|reactome:R-SCE-983168 psi-mi:"MI:0465"(dip) crc64:E5DC7F8E6AE27736 crc64:6EE6009545A3D0EF full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/05 2017/08/10 rogid:DaeRxapE6TgoZG4emWRb3y12Vfc559292 rogid:kvJ/LyyQGKi5JTh4Fek1kh70jOU559292 rigid:BBJqYup6ke0mD/Xk1S1oKA1rObU false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q12250 uniprotkb:Q04062 intact:EBI-15935|uniprotkb:D6VRK1|ensemblfungi:YDL147W intact:EBI-15944|uniprotkb:D6VT56|ensemblfungi:YDR427W psi-mi:rpn5_yeast(display_long)|uniprotkb:RPN5(gene name)|psi-mi:RPN5(display_short)|uniprotkb:NAS5(gene name synonym)|uniprotkb:YDL147W(locus name)|uniprotkb:D1572(orf name)|uniprotkb:Proteasome non-ATPase subunit 5(gene name synonym) psi-mi:rpn9_yeast(display_long)|uniprotkb:RPN9(gene name)|psi-mi:RPN9(display_short)|uniprotkb:NAS7(gene name synonym)|uniprotkb:YDR427W(locus name)|uniprotkb:D9461.14(orf name)|uniprotkb:Proteasome non-ATPase subunit 7(gene name synonym) psi-mi:"MI:0069"(mass spectrometry studies of complexes) Sharon et al. (2006) doi:10.1371/journal.pbio.0040267|pubmed:16869714|imex:IM-8531 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15593742|imex:IM-8531-7|dip:DIP-57219E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_010134.1|sgd:S000002306|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR035297|interpro:IPR036388|interpro:IPR036390|interpro:IPR040134|interpro:IPR040896|rcsb pdb:3J47|rcsb pdb:3JCK|rcsb pdb:3JCO|rcsb pdb:3JCP|rcsb pdb:4CR2|rcsb pdb:4CR3|rcsb pdb:4CR4|rcsb pdb:5A5B|rcsb pdb:5MPB|rcsb pdb:5MPC|rcsb pdb:5MPD|rcsb pdb:5MPE|rcsb pdb:5WVI|rcsb pdb:5WVK|rcsb pdb:5ZMR|rcsb pdb:6FVT|rcsb pdb:6FVU|rcsb pdb:6FVV|rcsb pdb:6FVW|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|rcsb pdb:6FVX|ensemblfungi:YDL147W(gene)|ensemblfungi:YDL147W_mRNA(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0000502"(proteasome complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0031595"(nuclear proteasome complex)|go:"GO:0034515"(proteasome storage granule)|rcsb pdb:6J2C|rcsb pdb:6FVY|rcsb pdb:6J2N|rcsb pdb:6J2Q|rcsb pdb:6J2X|rcsb pdb:6J30|reactome:R-SCE-1236978|reactome:R-SCE-174113|reactome:R-SCE-5668541|reactome:R-SCE-5687128|reactome:R-SCE-5689880|reactome:R-SCE-6798695|reactome:R-SCE-68949|reactome:R-SCE-69017|reactome:R-SCE-69601|reactome:R-SCE-75815|reactome:R-SCE-8854050|reactome:R-SCE-8948751|reactome:R-SCE-983168|dip:DIP-1578N|mint:Q12250 sgd:S000002835|ensemblfungi:YDR427W(gene)|ensemblfungi:YDR427W_mRNA(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0043248"(proteasome assembly)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR035298|interpro:IPR036390|interpro:IPR040798|rcsb pdb:2MQW|rcsb pdb:2MR3|rcsb pdb:2MRI|rcsb pdb:3J47|rcsb pdb:3JCK|rcsb pdb:3JCO|rcsb pdb:3JCP|rcsb pdb:4CR2|rcsb pdb:4CR3|rcsb pdb:4CR4|rcsb pdb:5A5B|rcsb pdb:5MPB|rcsb pdb:5MPC|rcsb pdb:5MPD|rcsb pdb:5MPE|rcsb pdb:5WVI|rcsb pdb:5WVK|rcsb pdb:6FVT|rcsb pdb:6FVU|rcsb pdb:6FVV|rcsb pdb:6FVW|rcsb pdb:6FVX|rcsb pdb:6FVY|rcsb pdb:6J2C|rcsb pdb:6J2N|rcsb pdb:6J2Q|rcsb pdb:6J2X|rcsb pdb:6J30|reactome:R-SCE-1236978|reactome:R-SCE-174113|reactome:R-SCE-5668541|reactome:R-SCE-5687128|reactome:R-SCE-5689880|reactome:R-SCE-6798695|reactome:R-SCE-68949|reactome:R-SCE-69017|reactome:R-SCE-69601|reactome:R-SCE-75815|reactome:R-SCE-8854050|reactome:R-SCE-8948751|reactome:R-SCE-983168|refseq:NP_010715.3|dip:DIP-5261N|mint:Q04062 psi-mi:"MI:0465"(dip) crc64:E5DC7F8E6AE27736 crc64:540F7DF8C23469A1 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/05 2017/08/10 rogid:DaeRxapE6TgoZG4emWRb3y12Vfc559292 rogid:hOAU0IY1VeRlmtX4Dw3MNJybZaE559292 rigid:BBJqYup6ke0mD/Xk1S1oKA1rObU false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P40016 uniprotkb:Q12250 intact:EBI-15927|uniprotkb:D3DLS0|ensemblfungi:YER021W intact:EBI-15935|uniprotkb:D6VRK1|ensemblfungi:YDL147W psi-mi:rpn3_yeast(display_long)|uniprotkb:RPN3(gene name)|psi-mi:RPN3(display_short)|uniprotkb:SUN2(gene name synonym)|uniprotkb:YER021W(locus name) psi-mi:rpn5_yeast(display_long)|uniprotkb:RPN5(gene name)|psi-mi:RPN5(display_short)|uniprotkb:NAS5(gene name synonym)|uniprotkb:YDL147W(locus name)|uniprotkb:D1572(orf name)|uniprotkb:Proteasome non-ATPase subunit 5(gene name synonym) psi-mi:"MI:0069"(mass spectrometry studies of complexes) Sharon et al. (2006) doi:10.1371/journal.pbio.0040267|pubmed:16869714|imex:IM-8531 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15593723|imex:IM-8531-1|dip:DIP-57218E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_010938.1|sgd:S000000823|ensemblfungi:YER021W(gene)|ensemblfungi:YER021W_mRNA(transcript)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0042176"(regulation of protein catabolic process)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR013586(26S proteasome regulatory subunit, C-terminal)|interpro:IPR035267|interpro:IPR036390|rcsb pdb:3J47|rcsb pdb:3JCK|rcsb pdb:3JCO|rcsb pdb:3JCP|rcsb pdb:4CR2|rcsb pdb:4CR3|rcsb pdb:4CR4|rcsb pdb:5A5B|rcsb pdb:5MPB|rcsb pdb:5MPC|rcsb pdb:5MPD|rcsb pdb:5MPE|rcsb pdb:5WVI|rcsb pdb:5WVK|rcsb pdb:6FVT|rcsb pdb:6FVU|rcsb pdb:6FVV|rcsb pdb:6FVW|rcsb pdb:6FVX|rcsb pdb:6FVY|rcsb pdb:6J2C|rcsb pdb:6J2N|rcsb pdb:6J2Q|rcsb pdb:6J2X|rcsb pdb:6J30|reactome:R-SCE-1236978|reactome:R-SCE-174113|reactome:R-SCE-5668541|reactome:R-SCE-5687128|reactome:R-SCE-5689880|reactome:R-SCE-6798695|reactome:R-SCE-68949|reactome:R-SCE-69017|reactome:R-SCE-69601|reactome:R-SCE-75815|reactome:R-SCE-8854050|reactome:R-SCE-8948751|reactome:R-SCE-983168|dip:DIP-1322N|mint:P40016 refseq:NP_010134.1|sgd:S000002306|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR035297|interpro:IPR036388|interpro:IPR036390|interpro:IPR040134|interpro:IPR040896|rcsb pdb:3J47|rcsb pdb:3JCK|rcsb pdb:3JCO|rcsb pdb:3JCP|rcsb pdb:4CR2|rcsb pdb:4CR3|rcsb pdb:4CR4|rcsb pdb:5A5B|rcsb pdb:5MPB|rcsb pdb:5MPC|rcsb pdb:5MPD|rcsb pdb:5MPE|rcsb pdb:5WVI|rcsb pdb:5WVK|rcsb pdb:5ZMR|rcsb pdb:6FVT|rcsb pdb:6FVU|rcsb pdb:6FVV|rcsb pdb:6FVW|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|rcsb pdb:6FVX|ensemblfungi:YDL147W(gene)|ensemblfungi:YDL147W_mRNA(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0000502"(proteasome complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0031595"(nuclear proteasome complex)|go:"GO:0034515"(proteasome storage granule)|rcsb pdb:6J2C|rcsb pdb:6FVY|rcsb pdb:6J2N|rcsb pdb:6J2Q|rcsb pdb:6J2X|rcsb pdb:6J30|reactome:R-SCE-1236978|reactome:R-SCE-174113|reactome:R-SCE-5668541|reactome:R-SCE-5687128|reactome:R-SCE-5689880|reactome:R-SCE-6798695|reactome:R-SCE-68949|reactome:R-SCE-69017|reactome:R-SCE-69601|reactome:R-SCE-75815|reactome:R-SCE-8854050|reactome:R-SCE-8948751|reactome:R-SCE-983168|dip:DIP-1578N|mint:Q12250 psi-mi:"MI:0465"(dip) crc64:B08B58663DDA85DC crc64:E5DC7F8E6AE27736 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/05 2017/08/10 rogid:pXkyoZKr0rI5usi19R+TvS4hSso559292 rogid:DaeRxapE6TgoZG4emWRb3y12Vfc559292 rigid:B8K1clSXje0pIvbF0UwPRj1zZaU false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P40016 uniprotkb:Q08723 intact:EBI-15927|uniprotkb:D3DLS0|ensemblfungi:YER021W intact:EBI-36176|uniprotkb:Q6Q5I7|uniprotkb:D6W2W2|ensemblfungi:YOR261C psi-mi:rpn3_yeast(display_long)|uniprotkb:RPN3(gene name)|psi-mi:RPN3(display_short)|uniprotkb:SUN2(gene name synonym)|uniprotkb:YER021W(locus name) psi-mi:rpn8_yeast(display_long)|uniprotkb:RPN8(gene name)|psi-mi:RPN8(display_short)|uniprotkb:O5360(orf name)|uniprotkb:YOR261C(locus name) psi-mi:"MI:0069"(mass spectrometry studies of complexes) Sharon et al. (2006) doi:10.1371/journal.pbio.0040267|pubmed:16869714|imex:IM-8531 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15593723|imex:IM-8531-1|dip:DIP-57218E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_010938.1|sgd:S000000823|ensemblfungi:YER021W(gene)|ensemblfungi:YER021W_mRNA(transcript)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0042176"(regulation of protein catabolic process)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR013586(26S proteasome regulatory subunit, C-terminal)|interpro:IPR035267|interpro:IPR036390|rcsb pdb:3J47|rcsb pdb:3JCK|rcsb pdb:3JCO|rcsb pdb:3JCP|rcsb pdb:4CR2|rcsb pdb:4CR3|rcsb pdb:4CR4|rcsb pdb:5A5B|rcsb pdb:5MPB|rcsb pdb:5MPC|rcsb pdb:5MPD|rcsb pdb:5MPE|rcsb pdb:5WVI|rcsb pdb:5WVK|rcsb pdb:6FVT|rcsb pdb:6FVU|rcsb pdb:6FVV|rcsb pdb:6FVW|rcsb pdb:6FVX|rcsb pdb:6FVY|rcsb pdb:6J2C|rcsb pdb:6J2N|rcsb pdb:6J2Q|rcsb pdb:6J2X|rcsb pdb:6J30|reactome:R-SCE-1236978|reactome:R-SCE-174113|reactome:R-SCE-5668541|reactome:R-SCE-5687128|reactome:R-SCE-5689880|reactome:R-SCE-6798695|reactome:R-SCE-68949|reactome:R-SCE-69017|reactome:R-SCE-69601|reactome:R-SCE-75815|reactome:R-SCE-8854050|reactome:R-SCE-8948751|reactome:R-SCE-983168|dip:DIP-1322N|mint:P40016 sgd:S000005787|refseq:NP_014904.3|mint:Q08723|dip:DIP-1574N|ensemblfungi:YOR261C(gene)|ensemblfungi:YOR261C_mRNA(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070122"(isopeptidase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR024969|interpro:IPR033858|interpro:IPR037518|rcsb pdb:3J47|rcsb pdb:3JCK|rcsb pdb:3JCO|rcsb pdb:3JCP|rcsb pdb:4CR2|rcsb pdb:4CR3|rcsb pdb:4CR4|rcsb pdb:4O8X|rcsb pdb:4O8Y|rcsb pdb:4OCL|rcsb pdb:4OCM|rcsb pdb:4OCN|rcsb pdb:4OWP|rcsb pdb:5A5B|rcsb pdb:5MPB|rcsb pdb:5MPC|rcsb pdb:5MPD|rcsb pdb:5MPE|rcsb pdb:5U4P|rcsb pdb:5W83|rcsb pdb:5WVI|rcsb pdb:5WVK|rcsb pdb:6FVT|rcsb pdb:6FVU|rcsb pdb:6FVV|rcsb pdb:6FVW|rcsb pdb:6FVX|rcsb pdb:6FVY|rcsb pdb:6J2C|rcsb pdb:6J2N|rcsb pdb:6J2Q|rcsb pdb:6J2X|rcsb pdb:6J30|reactome:R-SCE-1236978|reactome:R-SCE-174113|reactome:R-SCE-5668541|reactome:R-SCE-5687128|reactome:R-SCE-5689880|reactome:R-SCE-6798695|reactome:R-SCE-68949|reactome:R-SCE-69017|reactome:R-SCE-69601|reactome:R-SCE-75815|reactome:R-SCE-8854050|reactome:R-SCE-8948751|reactome:R-SCE-983168 psi-mi:"MI:0465"(dip) crc64:B08B58663DDA85DC crc64:6EE6009545A3D0EF full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/05 2017/08/10 rogid:pXkyoZKr0rI5usi19R+TvS4hSso559292 rogid:kvJ/LyyQGKi5JTh4Fek1kh70jOU559292 rigid:B8K1clSXje0pIvbF0UwPRj1zZaU false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P40016 uniprotkb:Q04062 intact:EBI-15927|uniprotkb:D3DLS0|ensemblfungi:YER021W intact:EBI-15944|uniprotkb:D6VT56|ensemblfungi:YDR427W psi-mi:rpn3_yeast(display_long)|uniprotkb:RPN3(gene name)|psi-mi:RPN3(display_short)|uniprotkb:SUN2(gene name synonym)|uniprotkb:YER021W(locus name) psi-mi:rpn9_yeast(display_long)|uniprotkb:RPN9(gene name)|psi-mi:RPN9(display_short)|uniprotkb:NAS7(gene name synonym)|uniprotkb:YDR427W(locus name)|uniprotkb:D9461.14(orf name)|uniprotkb:Proteasome non-ATPase subunit 7(gene name synonym) psi-mi:"MI:0069"(mass spectrometry studies of complexes) Sharon et al. (2006) doi:10.1371/journal.pbio.0040267|pubmed:16869714|imex:IM-8531 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15593723|imex:IM-8531-1|dip:DIP-57218E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_010938.1|sgd:S000000823|ensemblfungi:YER021W(gene)|ensemblfungi:YER021W_mRNA(transcript)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0042176"(regulation of protein catabolic process)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR013586(26S proteasome regulatory subunit, C-terminal)|interpro:IPR035267|interpro:IPR036390|rcsb pdb:3J47|rcsb pdb:3JCK|rcsb pdb:3JCO|rcsb pdb:3JCP|rcsb pdb:4CR2|rcsb pdb:4CR3|rcsb pdb:4CR4|rcsb pdb:5A5B|rcsb pdb:5MPB|rcsb pdb:5MPC|rcsb pdb:5MPD|rcsb pdb:5MPE|rcsb pdb:5WVI|rcsb pdb:5WVK|rcsb pdb:6FVT|rcsb pdb:6FVU|rcsb pdb:6FVV|rcsb pdb:6FVW|rcsb pdb:6FVX|rcsb pdb:6FVY|rcsb pdb:6J2C|rcsb pdb:6J2N|rcsb pdb:6J2Q|rcsb pdb:6J2X|rcsb pdb:6J30|reactome:R-SCE-1236978|reactome:R-SCE-174113|reactome:R-SCE-5668541|reactome:R-SCE-5687128|reactome:R-SCE-5689880|reactome:R-SCE-6798695|reactome:R-SCE-68949|reactome:R-SCE-69017|reactome:R-SCE-69601|reactome:R-SCE-75815|reactome:R-SCE-8854050|reactome:R-SCE-8948751|reactome:R-SCE-983168|dip:DIP-1322N|mint:P40016 sgd:S000002835|ensemblfungi:YDR427W(gene)|ensemblfungi:YDR427W_mRNA(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0043248"(proteasome assembly)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR035298|interpro:IPR036390|interpro:IPR040798|rcsb pdb:2MQW|rcsb pdb:2MR3|rcsb pdb:2MRI|rcsb pdb:3J47|rcsb pdb:3JCK|rcsb pdb:3JCO|rcsb pdb:3JCP|rcsb pdb:4CR2|rcsb pdb:4CR3|rcsb pdb:4CR4|rcsb pdb:5A5B|rcsb pdb:5MPB|rcsb pdb:5MPC|rcsb pdb:5MPD|rcsb pdb:5MPE|rcsb pdb:5WVI|rcsb pdb:5WVK|rcsb pdb:6FVT|rcsb pdb:6FVU|rcsb pdb:6FVV|rcsb pdb:6FVW|rcsb pdb:6FVX|rcsb pdb:6FVY|rcsb pdb:6J2C|rcsb pdb:6J2N|rcsb pdb:6J2Q|rcsb pdb:6J2X|rcsb pdb:6J30|reactome:R-SCE-1236978|reactome:R-SCE-174113|reactome:R-SCE-5668541|reactome:R-SCE-5687128|reactome:R-SCE-5689880|reactome:R-SCE-6798695|reactome:R-SCE-68949|reactome:R-SCE-69017|reactome:R-SCE-69601|reactome:R-SCE-75815|reactome:R-SCE-8854050|reactome:R-SCE-8948751|reactome:R-SCE-983168|refseq:NP_010715.3|dip:DIP-5261N|mint:Q04062 psi-mi:"MI:0465"(dip) crc64:B08B58663DDA85DC crc64:540F7DF8C23469A1 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/05 2017/08/10 rogid:pXkyoZKr0rI5usi19R+TvS4hSso559292 rogid:hOAU0IY1VeRlmtX4Dw3MNJybZaE559292 rigid:B8K1clSXje0pIvbF0UwPRj1zZaU false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P43588 uniprotkb:P40016 intact:EBI-11219|uniprotkb:Q8J0T5|uniprotkb:D6VTN4|ensemblfungi:YFR004W intact:EBI-15927|uniprotkb:D3DLS0|ensemblfungi:YER021W psi-mi:rpn11_yeast(display_long)|uniprotkb:YFR004W(locus name)|uniprotkb:RPN11(gene name)|psi-mi:RPN11(display_short)|uniprotkb:MPR1(gene name synonym)|uniprotkb:Protein MPR1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN11(gene name synonym) psi-mi:rpn3_yeast(display_long)|uniprotkb:RPN3(gene name)|psi-mi:RPN3(display_short)|uniprotkb:SUN2(gene name synonym)|uniprotkb:YER021W(locus name) psi-mi:"MI:0069"(mass spectrometry studies of complexes) Sharon et al. (2006) doi:10.1371/journal.pbio.0040267|pubmed:16869714|imex:IM-8531 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15593761|imex:IM-8531-4|dip:DIP-57220E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblfungi:YFR004W(gene)|ensemblfungi:YFR004W_mRNA(transcript)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0016559"(peroxisome fission)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043248"(proteasome assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070628"(proteasome binding)|go:"GO:1902906"(proteasome storage granule assembly)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR024969|interpro:IPR035299|interpro:IPR037518|rcsb pdb:3J47|rcsb pdb:3JCK|rcsb pdb:3JCO|rcsb pdb:3JCP|rcsb pdb:4CR2|rcsb pdb:4CR3|rcsb pdb:4CR4|rcsb pdb:4O8X|rcsb pdb:4O8Y|rcsb pdb:4OCL|rcsb pdb:4OCM|go:"GO:0070122"(isopeptidase activity)|rcsb pdb:4OCN|rcsb pdb:4OWP|rcsb pdb:5A5B|rcsb pdb:5MPB|rcsb pdb:5MPC|rcsb pdb:5MPD|rcsb pdb:5MPE|rcsb pdb:5U4P|rcsb pdb:5W83|rcsb pdb:5WVI|rcsb pdb:5WVK|rcsb pdb:6EF3|rcsb pdb:6FVT|rcsb pdb:6FVU|rcsb pdb:6FVV|rcsb pdb:6FVW|rcsb pdb:6FVX|rcsb pdb:6FVY|rcsb pdb:6J2C|rcsb pdb:6J2N|rcsb pdb:6J2Q|rcsb pdb:6J2X|rcsb pdb:6J30|reactome:R-SCE-1236978|reactome:R-SCE-174113|reactome:R-SCE-5668541|reactome:R-SCE-5687128|reactome:R-SCE-5689880|reactome:R-SCE-5689901|reactome:R-SCE-6798695|reactome:R-SCE-68949|reactome:R-SCE-69017|reactome:R-SCE-69601|reactome:R-SCE-75815|reactome:R-SCE-8854050|reactome:R-SCE-8948751|reactome:R-SCE-983168|refseq:NP_116659.1|sgd:S000001900|mint:P43588|dip:DIP-1573N refseq:NP_010938.1|sgd:S000000823|ensemblfungi:YER021W(gene)|ensemblfungi:YER021W_mRNA(transcript)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0042176"(regulation of protein catabolic process)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR013586(26S proteasome regulatory subunit, C-terminal)|interpro:IPR035267|interpro:IPR036390|rcsb pdb:3J47|rcsb pdb:3JCK|rcsb pdb:3JCO|rcsb pdb:3JCP|rcsb pdb:4CR2|rcsb pdb:4CR3|rcsb pdb:4CR4|rcsb pdb:5A5B|rcsb pdb:5MPB|rcsb pdb:5MPC|rcsb pdb:5MPD|rcsb pdb:5MPE|rcsb pdb:5WVI|rcsb pdb:5WVK|rcsb pdb:6FVT|rcsb pdb:6FVU|rcsb pdb:6FVV|rcsb pdb:6FVW|rcsb pdb:6FVX|rcsb pdb:6FVY|rcsb pdb:6J2C|rcsb pdb:6J2N|rcsb pdb:6J2Q|rcsb pdb:6J2X|rcsb pdb:6J30|reactome:R-SCE-1236978|reactome:R-SCE-174113|reactome:R-SCE-5668541|reactome:R-SCE-5687128|reactome:R-SCE-5689880|reactome:R-SCE-6798695|reactome:R-SCE-68949|reactome:R-SCE-69017|reactome:R-SCE-69601|reactome:R-SCE-75815|reactome:R-SCE-8854050|reactome:R-SCE-8948751|reactome:R-SCE-983168|dip:DIP-1322N|mint:P40016 psi-mi:"MI:0465"(dip) crc64:9DDE8BD74890894D crc64:B08B58663DDA85DC full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/05 2017/08/10 rogid:f3lAMY9siMcO2dAOfKvVrvKzfNM559292 rogid:pXkyoZKr0rI5usi19R+TvS4hSso559292 rigid:6dgti9hkc3LuhhU1wdB2oFD491Y false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P43588 uniprotkb:Q12250 intact:EBI-11219|uniprotkb:Q8J0T5|uniprotkb:D6VTN4|ensemblfungi:YFR004W intact:EBI-15935|uniprotkb:D6VRK1|ensemblfungi:YDL147W psi-mi:rpn11_yeast(display_long)|uniprotkb:YFR004W(locus name)|uniprotkb:RPN11(gene name)|psi-mi:RPN11(display_short)|uniprotkb:MPR1(gene name synonym)|uniprotkb:Protein MPR1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN11(gene name synonym) psi-mi:rpn5_yeast(display_long)|uniprotkb:RPN5(gene name)|psi-mi:RPN5(display_short)|uniprotkb:NAS5(gene name synonym)|uniprotkb:YDL147W(locus name)|uniprotkb:D1572(orf name)|uniprotkb:Proteasome non-ATPase subunit 5(gene name synonym) psi-mi:"MI:0069"(mass spectrometry studies of complexes) Sharon et al. (2006) doi:10.1371/journal.pbio.0040267|pubmed:16869714|imex:IM-8531 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15593761|imex:IM-8531-4|dip:DIP-57220E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblfungi:YFR004W(gene)|ensemblfungi:YFR004W_mRNA(transcript)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0016559"(peroxisome fission)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043248"(proteasome assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070628"(proteasome binding)|go:"GO:1902906"(proteasome storage granule assembly)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR024969|interpro:IPR035299|interpro:IPR037518|rcsb pdb:3J47|rcsb pdb:3JCK|rcsb pdb:3JCO|rcsb pdb:3JCP|rcsb pdb:4CR2|rcsb pdb:4CR3|rcsb pdb:4CR4|rcsb pdb:4O8X|rcsb pdb:4O8Y|rcsb pdb:4OCL|rcsb pdb:4OCM|go:"GO:0070122"(isopeptidase activity)|rcsb pdb:4OCN|rcsb pdb:4OWP|rcsb pdb:5A5B|rcsb pdb:5MPB|rcsb pdb:5MPC|rcsb pdb:5MPD|rcsb pdb:5MPE|rcsb pdb:5U4P|rcsb pdb:5W83|rcsb pdb:5WVI|rcsb pdb:5WVK|rcsb pdb:6EF3|rcsb pdb:6FVT|rcsb pdb:6FVU|rcsb pdb:6FVV|rcsb pdb:6FVW|rcsb pdb:6FVX|rcsb pdb:6FVY|rcsb pdb:6J2C|rcsb pdb:6J2N|rcsb pdb:6J2Q|rcsb pdb:6J2X|rcsb pdb:6J30|reactome:R-SCE-1236978|reactome:R-SCE-174113|reactome:R-SCE-5668541|reactome:R-SCE-5687128|reactome:R-SCE-5689880|reactome:R-SCE-5689901|reactome:R-SCE-6798695|reactome:R-SCE-68949|reactome:R-SCE-69017|reactome:R-SCE-69601|reactome:R-SCE-75815|reactome:R-SCE-8854050|reactome:R-SCE-8948751|reactome:R-SCE-983168|refseq:NP_116659.1|sgd:S000001900|mint:P43588|dip:DIP-1573N refseq:NP_010134.1|sgd:S000002306|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR035297|interpro:IPR036388|interpro:IPR036390|interpro:IPR040134|interpro:IPR040896|rcsb pdb:3J47|rcsb pdb:3JCK|rcsb pdb:3JCO|rcsb pdb:3JCP|rcsb pdb:4CR2|rcsb pdb:4CR3|rcsb pdb:4CR4|rcsb pdb:5A5B|rcsb pdb:5MPB|rcsb pdb:5MPC|rcsb pdb:5MPD|rcsb pdb:5MPE|rcsb pdb:5WVI|rcsb pdb:5WVK|rcsb pdb:5ZMR|rcsb pdb:6FVT|rcsb pdb:6FVU|rcsb pdb:6FVV|rcsb pdb:6FVW|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|rcsb pdb:6FVX|ensemblfungi:YDL147W(gene)|ensemblfungi:YDL147W_mRNA(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0000502"(proteasome complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0031595"(nuclear proteasome complex)|go:"GO:0034515"(proteasome storage granule)|rcsb pdb:6J2C|rcsb pdb:6FVY|rcsb pdb:6J2N|rcsb pdb:6J2Q|rcsb pdb:6J2X|rcsb pdb:6J30|reactome:R-SCE-1236978|reactome:R-SCE-174113|reactome:R-SCE-5668541|reactome:R-SCE-5687128|reactome:R-SCE-5689880|reactome:R-SCE-6798695|reactome:R-SCE-68949|reactome:R-SCE-69017|reactome:R-SCE-69601|reactome:R-SCE-75815|reactome:R-SCE-8854050|reactome:R-SCE-8948751|reactome:R-SCE-983168|dip:DIP-1578N|mint:Q12250 psi-mi:"MI:0465"(dip) crc64:9DDE8BD74890894D crc64:E5DC7F8E6AE27736 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/05 2017/08/10 rogid:f3lAMY9siMcO2dAOfKvVrvKzfNM559292 rogid:DaeRxapE6TgoZG4emWRb3y12Vfc559292 rigid:6dgti9hkc3LuhhU1wdB2oFD491Y false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P43588 uniprotkb:Q06103 intact:EBI-11219|uniprotkb:Q8J0T5|uniprotkb:D6VTN4|ensemblfungi:YFR004W intact:EBI-15940|uniprotkb:D6W4A6|uniprotkb:E9P8W9|ensemblfungi:YPR108W psi-mi:rpn11_yeast(display_long)|uniprotkb:YFR004W(locus name)|uniprotkb:RPN11(gene name)|psi-mi:RPN11(display_short)|uniprotkb:MPR1(gene name synonym)|uniprotkb:Protein MPR1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN11(gene name synonym) psi-mi:rpn7_yeast(display_long)|uniprotkb:RPN7(gene name)|psi-mi:RPN7(display_short)|uniprotkb:P8283.8(orf name)|uniprotkb:YPR108W(locus name) psi-mi:"MI:0069"(mass spectrometry studies of complexes) Sharon et al. (2006) doi:10.1371/journal.pbio.0040267|pubmed:16869714|imex:IM-8531 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15593761|imex:IM-8531-4|dip:DIP-57220E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblfungi:YFR004W(gene)|ensemblfungi:YFR004W_mRNA(transcript)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0016559"(peroxisome fission)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043248"(proteasome assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070628"(proteasome binding)|go:"GO:1902906"(proteasome storage granule assembly)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR024969|interpro:IPR035299|interpro:IPR037518|rcsb pdb:3J47|rcsb pdb:3JCK|rcsb pdb:3JCO|rcsb pdb:3JCP|rcsb pdb:4CR2|rcsb pdb:4CR3|rcsb pdb:4CR4|rcsb pdb:4O8X|rcsb pdb:4O8Y|rcsb pdb:4OCL|rcsb pdb:4OCM|go:"GO:0070122"(isopeptidase activity)|rcsb pdb:4OCN|rcsb pdb:4OWP|rcsb pdb:5A5B|rcsb pdb:5MPB|rcsb pdb:5MPC|rcsb pdb:5MPD|rcsb pdb:5MPE|rcsb pdb:5U4P|rcsb pdb:5W83|rcsb pdb:5WVI|rcsb pdb:5WVK|rcsb pdb:6EF3|rcsb pdb:6FVT|rcsb pdb:6FVU|rcsb pdb:6FVV|rcsb pdb:6FVW|rcsb pdb:6FVX|rcsb pdb:6FVY|rcsb pdb:6J2C|rcsb pdb:6J2N|rcsb pdb:6J2Q|rcsb pdb:6J2X|rcsb pdb:6J30|reactome:R-SCE-1236978|reactome:R-SCE-174113|reactome:R-SCE-5668541|reactome:R-SCE-5687128|reactome:R-SCE-5689880|reactome:R-SCE-5689901|reactome:R-SCE-6798695|reactome:R-SCE-68949|reactome:R-SCE-69017|reactome:R-SCE-69601|reactome:R-SCE-75815|reactome:R-SCE-8854050|reactome:R-SCE-8948751|reactome:R-SCE-983168|refseq:NP_116659.1|sgd:S000001900|mint:P43588|dip:DIP-1573N refseq:NP_015433.1|sgd:S000006312|ensemblfungi:YPR108W(gene)|ensemblfungi:YPR108W_mRNA(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005634"(nucleus)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019585|interpro:IPR019734|interpro:IPR035268|interpro:IPR036390|rcsb pdb:5MPB|rcsb pdb:5MPC|rcsb pdb:5MPD|rcsb pdb:5MPE|rcsb pdb:5WVI|rcsb pdb:5WVK|rcsb pdb:6FVT|rcsb pdb:6FVU|rcsb pdb:6FVV|rcsb pdb:6FVW|rcsb pdb:6FVX|rcsb pdb:6FVY|rcsb pdb:6J2C|rcsb pdb:6J2N|rcsb pdb:6J2Q|rcsb pdb:6J2X|rcsb pdb:6J30|reactome:R-SCE-1236978|reactome:R-SCE-174113|rcsb pdb:3J47|reactome:R-SCE-5668541|reactome:R-SCE-5687128|reactome:R-SCE-5689880|reactome:R-SCE-6798695|reactome:R-SCE-68949|reactome:R-SCE-69017|reactome:R-SCE-69601|reactome:R-SCE-75815|rcsb pdb:3JCK|reactome:R-SCE-8854050|reactome:R-SCE-8948751|reactome:R-SCE-983168|rcsb pdb:3JCO|rcsb pdb:3JCP|rcsb pdb:4CR2|rcsb pdb:4CR3|rcsb pdb:4CR4|rcsb pdb:5A5B|dip:DIP-2880N|mint:Q06103 psi-mi:"MI:0465"(dip) crc64:9DDE8BD74890894D crc64:B21B66CD818E636D full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/05 2017/08/10 rogid:f3lAMY9siMcO2dAOfKvVrvKzfNM559292 rogid:RVj0KoFtiJVk9oF3cYIftSVLejc559292 rigid:6dgti9hkc3LuhhU1wdB2oFD491Y false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P43588 uniprotkb:Q04062 intact:EBI-11219|uniprotkb:Q8J0T5|uniprotkb:D6VTN4|ensemblfungi:YFR004W intact:EBI-15944|uniprotkb:D6VT56|ensemblfungi:YDR427W psi-mi:rpn11_yeast(display_long)|uniprotkb:YFR004W(locus name)|uniprotkb:RPN11(gene name)|psi-mi:RPN11(display_short)|uniprotkb:MPR1(gene name synonym)|uniprotkb:Protein MPR1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN11(gene name synonym) psi-mi:rpn9_yeast(display_long)|uniprotkb:RPN9(gene name)|psi-mi:RPN9(display_short)|uniprotkb:NAS7(gene name synonym)|uniprotkb:YDR427W(locus name)|uniprotkb:D9461.14(orf name)|uniprotkb:Proteasome non-ATPase subunit 7(gene name synonym) psi-mi:"MI:0069"(mass spectrometry studies of complexes) Sharon et al. (2006) doi:10.1371/journal.pbio.0040267|pubmed:16869714|imex:IM-8531 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15593761|imex:IM-8531-4|dip:DIP-57220E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblfungi:YFR004W(gene)|ensemblfungi:YFR004W_mRNA(transcript)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0016559"(peroxisome fission)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043248"(proteasome assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070628"(proteasome binding)|go:"GO:1902906"(proteasome storage granule assembly)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR024969|interpro:IPR035299|interpro:IPR037518|rcsb pdb:3J47|rcsb pdb:3JCK|rcsb pdb:3JCO|rcsb pdb:3JCP|rcsb pdb:4CR2|rcsb pdb:4CR3|rcsb pdb:4CR4|rcsb pdb:4O8X|rcsb pdb:4O8Y|rcsb pdb:4OCL|rcsb pdb:4OCM|go:"GO:0070122"(isopeptidase activity)|rcsb pdb:4OCN|rcsb pdb:4OWP|rcsb pdb:5A5B|rcsb pdb:5MPB|rcsb pdb:5MPC|rcsb pdb:5MPD|rcsb pdb:5MPE|rcsb pdb:5U4P|rcsb pdb:5W83|rcsb pdb:5WVI|rcsb pdb:5WVK|rcsb pdb:6EF3|rcsb pdb:6FVT|rcsb pdb:6FVU|rcsb pdb:6FVV|rcsb pdb:6FVW|rcsb pdb:6FVX|rcsb pdb:6FVY|rcsb pdb:6J2C|rcsb pdb:6J2N|rcsb pdb:6J2Q|rcsb pdb:6J2X|rcsb pdb:6J30|reactome:R-SCE-1236978|reactome:R-SCE-174113|reactome:R-SCE-5668541|reactome:R-SCE-5687128|reactome:R-SCE-5689880|reactome:R-SCE-5689901|reactome:R-SCE-6798695|reactome:R-SCE-68949|reactome:R-SCE-69017|reactome:R-SCE-69601|reactome:R-SCE-75815|reactome:R-SCE-8854050|reactome:R-SCE-8948751|reactome:R-SCE-983168|refseq:NP_116659.1|sgd:S000001900|mint:P43588|dip:DIP-1573N sgd:S000002835|ensemblfungi:YDR427W(gene)|ensemblfungi:YDR427W_mRNA(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0043248"(proteasome assembly)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR035298|interpro:IPR036390|interpro:IPR040798|rcsb pdb:2MQW|rcsb pdb:2MR3|rcsb pdb:2MRI|rcsb pdb:3J47|rcsb pdb:3JCK|rcsb pdb:3JCO|rcsb pdb:3JCP|rcsb pdb:4CR2|rcsb pdb:4CR3|rcsb pdb:4CR4|rcsb pdb:5A5B|rcsb pdb:5MPB|rcsb pdb:5MPC|rcsb pdb:5MPD|rcsb pdb:5MPE|rcsb pdb:5WVI|rcsb pdb:5WVK|rcsb pdb:6FVT|rcsb pdb:6FVU|rcsb pdb:6FVV|rcsb pdb:6FVW|rcsb pdb:6FVX|rcsb pdb:6FVY|rcsb pdb:6J2C|rcsb pdb:6J2N|rcsb pdb:6J2Q|rcsb pdb:6J2X|rcsb pdb:6J30|reactome:R-SCE-1236978|reactome:R-SCE-174113|reactome:R-SCE-5668541|reactome:R-SCE-5687128|reactome:R-SCE-5689880|reactome:R-SCE-6798695|reactome:R-SCE-68949|reactome:R-SCE-69017|reactome:R-SCE-69601|reactome:R-SCE-75815|reactome:R-SCE-8854050|reactome:R-SCE-8948751|reactome:R-SCE-983168|refseq:NP_010715.3|dip:DIP-5261N|mint:Q04062 psi-mi:"MI:0465"(dip) crc64:9DDE8BD74890894D crc64:540F7DF8C23469A1 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/05 2017/08/10 rogid:f3lAMY9siMcO2dAOfKvVrvKzfNM559292 rogid:hOAU0IY1VeRlmtX4Dw3MNJybZaE559292 rigid:6dgti9hkc3LuhhU1wdB2oFD491Y false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry)