#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P03116	uniprotkb:P03116	intact:EBI-7015985|intact:MINT-91530|uniprotkb:Q9WMH1	intact:EBI-7015985|intact:MINT-91530|uniprotkb:Q9WMH1	psi-mi:ve1_bpv1(display_long)|uniprotkb:E1(gene name)|psi-mi:E1(display_short)|uniprotkb:ATP-dependent helicase E1(gene name synonym)	psi-mi:ve1_bpv1(display_long)|uniprotkb:E1(gene name)|psi-mi:E1(display_short)|uniprotkb:ATP-dependent helicase E1(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Enemark et al. (2006)	pubmed:16855583|doi:10.1038/nature04943|imex:IM-21457	taxid:337052(bpv1)|taxid:337052(Bovine papillomavirus type 1)	taxid:337052(bpv1)|taxid:337052(Bovine papillomavirus type 1)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15592356|imex:IM-21457-1|dip:DIP-191615E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:P03116|refseq:NP_056739.1|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006260"(DNA replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001177(DNA helicase E1 protein, C-terminal, Papillomavirus)|interpro:IPR014000(DNA helicase E1 protein, N-terminal, Papillomavirus)|interpro:IPR014015(Helicase, superfamily 3, DNA virus)|interpro:IPR016393(Replication protein E1, papillomavirus)|interpro:IPR027417|rcsb pdb:1F08|rcsb pdb:1KSX|rcsb pdb:1KSY|rcsb pdb:2GXA|rcsb pdb:2V9P|rcsb pdb:5A9K|dip:DIP-40903N	mint:P03116|refseq:NP_056739.1|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006260"(DNA replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001177(DNA helicase E1 protein, C-terminal, Papillomavirus)|interpro:IPR014000(DNA helicase E1 protein, N-terminal, Papillomavirus)|interpro:IPR014015(Helicase, superfamily 3, DNA virus)|interpro:IPR016393(Replication protein E1, papillomavirus)|interpro:IPR027417|rcsb pdb:1F08|rcsb pdb:1KSX|rcsb pdb:1KSY|rcsb pdb:2GXA|rcsb pdb:2V9P|rcsb pdb:5A9K|dip:DIP-40903N	psi-mi:"MI:0465"(dip)	comment:mint|function:ATP-dependent DNA helicase required for initiation of viral DNA replication. It forms a complex with the viral E2 protein. The E1-E2 complex binds to the replication origin which contains binding sites for both proteins	comment:mint|function:ATP-dependent DNA helicase required for initiation of viral DNA replication. It forms a complex with the viral E2 protein. The E1-E2 complex binds to the replication origin which contains binding sites for both proteins	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/05	2017/08/10	rogid:7Fn7e9YGTrgaAWIHaZqHEKhZtfE337052	rogid:7Fn7e9YGTrgaAWIHaZqHEKhZtfE337052	rigid:89JhWZu8+7w4f67iaDDQcJSD3uY	false	sufficient binding region:306-577	sufficient binding region:306-577	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)