#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9H244 uniprotkb:Q9H244 intact:EBI-15591115|ensembl:ENSP00000307259|uniprotkb:D3DNJ5|uniprotkb:Q546J7 intact:EBI-15591115|ensembl:ENSP00000307259|uniprotkb:D3DNJ5|uniprotkb:Q546J7 psi-mi:p2y12_human(display_long)|uniprotkb:P2RY12(gene name)|psi-mi:P2RY12(display_short)|uniprotkb:HORK3(gene name synonym)|uniprotkb:ADP-glucose receptor(gene name synonym)|uniprotkb:"P2T(AC)"(gene name synonym)|uniprotkb:"P2Y(AC)"(gene name synonym)|uniprotkb:"P2Y(cyc)"(gene name synonym)|uniprotkb:P2Y12 platelet ADP receptor(gene name synonym)|uniprotkb:SP1999(gene name synonym) psi-mi:p2y12_human(display_long)|uniprotkb:P2RY12(gene name)|psi-mi:P2RY12(display_short)|uniprotkb:HORK3(gene name synonym)|uniprotkb:ADP-glucose receptor(gene name synonym)|uniprotkb:"P2T(AC)"(gene name synonym)|uniprotkb:"P2Y(AC)"(gene name synonym)|uniprotkb:"P2Y(cyc)"(gene name synonym)|uniprotkb:P2Y12 platelet ADP receptor(gene name synonym)|uniprotkb:SP1999(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Savi et al. (2006) pubmed:16835302|doi:10.1073/pnas.0510446103|imex:IM-23767 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15591174|imex:IM-23767-1|dip:DIP-197853E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000169313(gene)|ensembl:ENST00000302632(transcript)|go:"GO:0007599"(hemostasis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0001609"(G protein-coupled adenosine receptor activity)|go:"GO:0001621"(G protein-coupled ADP receptor activity)|go:"GO:0009986"(cell surface)|go:"GO:0010700"(negative regulation of norepinephrine secretion)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0005739"(mitochondrion)|go:"GO:0021808"(cytosolic calcium signaling involved in initiation of cell movement in glial-mediated radial cell migration)|go:"GO:0030030"(cell projection organization)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0005886"(plasma membrane)|go:"GO:0030168"(platelet activation)|go:"GO:0031224"(intrinsic component of membrane)|go:"GO:0031253"(cell projection membrane)|go:"GO:0033626"(positive regulation of integrin activation by cell surface receptor linked signal transduction)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0035585"(calcium-mediated signaling using extracellular calcium source)|go:"GO:0043270"(positive regulation of ion transport)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0005901"(caveola)|go:"GO:0044298"(cell body membrane)|go:"GO:0045028"(G protein-coupled purinergic nucleotide receptor activity)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0048678"(response to axon injury)|go:"GO:0050920"(regulation of chemotaxis)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0070527"(platelet aggregation)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071318"(cellular response to ATP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0150063"(visual system development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1904124"(microglial cell migration)|go:"GO:1904139"(regulation of microglial cell migration)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR005394(P2Y12 purinoceptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:1T78|rcsb pdb:1VZ1|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|rcsb pdb:1Y9C|rcsb pdb:4NTJ|rcsb pdb:4PXZ|rcsb pdb:4PY0|reactome:R-HSA-392170|reactome:R-HSA-417957|reactome:R-HSA-418594|go:"GO:0007202"(activation of phospholipase C activity)|refseq:NP_073625.1|refseq:NP_795345.1|refseq:XP_016862558.1|dip:DIP-61226N ensembl:ENSG00000169313(gene)|ensembl:ENST00000302632(transcript)|go:"GO:0007599"(hemostasis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0001609"(G protein-coupled adenosine receptor activity)|go:"GO:0001621"(G protein-coupled ADP receptor activity)|go:"GO:0009986"(cell surface)|go:"GO:0010700"(negative regulation of norepinephrine secretion)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0005739"(mitochondrion)|go:"GO:0021808"(cytosolic calcium signaling involved in initiation of cell movement in glial-mediated radial cell migration)|go:"GO:0030030"(cell projection organization)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0005886"(plasma membrane)|go:"GO:0030168"(platelet activation)|go:"GO:0031224"(intrinsic component of membrane)|go:"GO:0031253"(cell projection membrane)|go:"GO:0033626"(positive regulation of integrin activation by cell surface receptor linked signal transduction)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0035585"(calcium-mediated signaling using extracellular calcium source)|go:"GO:0043270"(positive regulation of ion transport)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0005901"(caveola)|go:"GO:0044298"(cell body membrane)|go:"GO:0045028"(G protein-coupled purinergic nucleotide receptor activity)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0048678"(response to axon injury)|go:"GO:0050920"(regulation of chemotaxis)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0070527"(platelet aggregation)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071318"(cellular response to ATP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0150063"(visual system development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1904124"(microglial cell migration)|go:"GO:1904139"(regulation of microglial cell migration)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR005394(P2Y12 purinoceptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:1T78|rcsb pdb:1VZ1|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|rcsb pdb:1Y9C|rcsb pdb:4NTJ|rcsb pdb:4PXZ|rcsb pdb:4PY0|reactome:R-HSA-392170|reactome:R-HSA-417957|reactome:R-HSA-418594|go:"GO:0007202"(activation of phospholipase C activity)|refseq:NP_073625.1|refseq:NP_795345.1|refseq:XP_016862558.1|dip:DIP-61226N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/05 2017/08/10 rogid:hVPOQvm7Y4b1lihQ7DLrcIUCfEk9606 rogid:hVPOQvm7Y4b1lihQ7DLrcIUCfEk9606 rigid:yOg+zvdOByRDCOUfatRi0+ha7Sk false ha tag:n-n myc tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot)