#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q6KC79 uniprotkb:Q9Y6X3 intact:EBI-722767|uniprotkb:Q6KCD6|uniprotkb:Q6N080|uniprotkb:Q6ZT92|uniprotkb:Q7Z2E6|uniprotkb:Q8N4M5|uniprotkb:Q9Y6Y3|uniprotkb:Q9Y6Y4|ensembl:ENSP00000282516 intact:EBI-4395624|uniprotkb:Q66PT1|uniprotkb:Q6P3S7|uniprotkb:Q6ZTT2|uniprotkb:Q9UFX8|intact:EBI-28974208|ensembl:ENSP00000262815 psi-mi:nipbl_human(display_long)|uniprotkb:Delangin(gene name synonym)|uniprotkb:SCC2 homolog(gene name synonym)|uniprotkb:NIPBL(gene name)|psi-mi:NIPBL(display_short)|uniprotkb:IDN3(gene name synonym)|uniprotkb:SCC2(gene name synonym) psi-mi:scc4_human(display_long)|uniprotkb:MAU2(gene name)|psi-mi:MAU2(display_short)|uniprotkb:KIAA0892(gene name synonym)|uniprotkb:SCC4(gene name synonym)|uniprotkb:Cohesin loading complex subunit SCC4 homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Seitan et al. (2006) pubmed:16802858|doi:10.1371/journal.pbio.0040242|imex:IM-8528 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15589885|imex:IM-8528-3|dip:DIP-57213E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056199.2|refseq:NP_597677.2|refseq:XP_016864819.1|dip:DIP-29199N|ensembl:ENSG00000164190(gene)|ensembl:ENST00000282516(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0001656"(metanephros development)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0007420"(brain development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0032039"(integrator complex)|go:"GO:0032116"(SMC loading complex)|go:"GO:0034087"(establishment of mitotic sister chromatid cohesion)|go:"GO:0034088"(maintenance of mitotic sister chromatid cohesion)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035136"(forelimb morphogenesis)|go:"GO:0035261"(external genitalia morphogenesis)|go:"GO:0036033"(mediator complex binding)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042471"(ear morphogenesis)|go:"GO:0042634"(regulation of hair cycle)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048557"(embryonic digestive tract morphogenesis)|go:"GO:0048565"(digestive tract development)|go:"GO:0048589"(developmental growth)|go:"GO:0048592"(eye morphogenesis)|go:"GO:0048638"(regulation of developmental growth)|go:"GO:0048703"(embryonic viscerocranium morphogenesis)|go:"GO:0050890"(cognition)|go:"GO:0060325"(face morphogenesis)|go:"GO:0061010"(gall bladder development)|go:"GO:0061038"(uterus morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070087"(chromo shadow domain binding)|go:"GO:0071169"(establishment of protein localization to chromatin)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0071921"(cohesin loading)|go:"GO:0090694"(Scc2-Scc4 cohesin loading complex)|go:"GO:1905406"(positive regulation of mitotic cohesin loading)|go:"GO:1990414"(replication-born double-strand break repair via sister chromatid exchange)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2001224"(positive regulation of neuron migration)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026003|interpro:IPR033031|rcsb pdb:6WG3|rcsb pdb:6WGE|reactome:R-HSA-2470946|interpro:IPR024986 refseq:NP_056144.3|ensembl:ENSP00000262815|dip:DIP-29196N|ensembl:ENSG00000129933(gene)|ensembl:ENST00000262815(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0016604"(nuclear body)|go:"GO:0032116"(SMC loading complex)|go:"GO:0034088"(maintenance of mitotic sister chromatid cohesion)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051301"(cell division)|go:"GO:0071921"(cohesin loading)|go:"GO:0090694"(Scc2-Scc4 cohesin loading complex)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019440|interpro:IPR019734|reactome:R-HSA-2470946 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/05 2017/08/10 rogid:RaZLQ4CmlJD/3QUl7n1JKBT23GM9606 rogid:38P0UWq8zlICr3G4DeJShwt8C/c9606 rigid:P+InWRt6NKfW3+1pV8f1TLeBb7k false - green fluorescent protein tag:n-n - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9VFC0 uniprotkb:Q7PLI2 intact:EBI-96488|ensemblmetazoa:FBpp0082507 intact:EBI-285830|uniprotkb:A4UZ37|uniprotkb:Q058T3|uniprotkb:Q058T4|uniprotkb:Q7PLI3|uniprotkb:Q9XYM2|ensemblmetazoa:FBpp0110410|ensemblmetazoa:FBpp0110411 psi-mi:scc4_drome(display_long)|uniprotkb:Mau2(gene name)|psi-mi:Mau2(display_short)|uniprotkb:Cohesin loading complex subunit SCC4 homolog(gene name synonym)|uniprotkb:Mau2 sister chromatid cohesion factor(gene name synonym)|uniprotkb:CG4203(orf name) psi-mi:nipb_drome(display_long)|uniprotkb:SCC2 homolog(gene name synonym)|uniprotkb:Nipped-B(gene name)|psi-mi:Nipped-B(display_short)|uniprotkb:CG17704(orf name) psi-mi:"MI:0004"(affinity chromatography technology) Seitan et al. (2006) pubmed:16802858|doi:10.1371/journal.pbio.0040242|imex:IM-8528 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15589866|imex:IM-8528-5|dip:DIP-57212E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_650428.1|flybase:FBgn0038300|ensemblmetazoa:FBgn0038300(gene)|ensemblmetazoa:FBtr0083048(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007411"(axon guidance)|go:"GO:0032116"(SMC loading complex)|go:"GO:0034088"(maintenance of mitotic sister chromatid cohesion)|go:"GO:0051301"(cell division)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019440|reactome:R-DME-2470946|dip:DIP-29197N refseq:NP_001036451.1|refseq:NP_001036452.1|flybase:FBgn0026401|dip:DIP-29198N|ensemblmetazoa:FBgn0026401(gene)|ensemblmetazoa:FBtr0111118(transcript)|ensemblmetazoa:FBtr0111119(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005700"(polytene chromosome)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0007612"(learning)|go:"GO:0007614"(short-term memory)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032116"(SMC loading complex)|go:"GO:0034087"(establishment of mitotic sister chromatid cohesion)|go:"GO:0034088"(maintenance of mitotic sister chromatid cohesion)|go:"GO:0035327"|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045927"(positive regulation of growth)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050802"(circadian sleep/wake cycle, sleep)|go:"GO:0061780"(mitotic cohesin loading)|go:"GO:0070193"(synaptonemal complex organization)|go:"GO:0071169"(establishment of protein localization to chromatin)|go:"GO:0090694"(Scc2-Scc4 cohesin loading complex)|go:"GO:0140588"(chromatin looping)|go:"GO:1905406"(positive regulation of mitotic cohesin loading)|go:"GO:1990414"(replication-born double-strand break repair via sister chromatid exchange)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024986|interpro:IPR026003|interpro:IPR033031|reactome:R-DME-2470946 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") - 2017/08/05 2017/08/10 rogid:BUox4vHF6ulhKKyhiEjBhzsXQ347227 rogid:X9kdFjrSMIasNBqvfGjB1EEgOp47227 rigid:iLLTN2C1/VJBYfJCYIp3eIxoCVs false - flag tag:n-n - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q6KC79 uniprotkb:Q9Y6X3 intact:EBI-722767|uniprotkb:Q6KCD6|uniprotkb:Q6N080|uniprotkb:Q6ZT92|uniprotkb:Q7Z2E6|uniprotkb:Q8N4M5|uniprotkb:Q9Y6Y3|uniprotkb:Q9Y6Y4|ensembl:ENSP00000282516 intact:EBI-4395624|uniprotkb:Q66PT1|uniprotkb:Q6P3S7|uniprotkb:Q6ZTT2|uniprotkb:Q9UFX8|intact:EBI-28974208|ensembl:ENSP00000262815 psi-mi:nipbl_human(display_long)|uniprotkb:Delangin(gene name synonym)|uniprotkb:SCC2 homolog(gene name synonym)|uniprotkb:NIPBL(gene name)|psi-mi:NIPBL(display_short)|uniprotkb:IDN3(gene name synonym)|uniprotkb:SCC2(gene name synonym) psi-mi:scc4_human(display_long)|uniprotkb:MAU2(gene name)|psi-mi:MAU2(display_short)|uniprotkb:KIAA0892(gene name synonym)|uniprotkb:SCC4(gene name synonym)|uniprotkb:Cohesin loading complex subunit SCC4 homolog(gene name synonym) psi-mi:"MI:0018"(two hybrid) Seitan et al. (2006) pubmed:16802858|doi:10.1371/journal.pbio.0040242|imex:IM-8528 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15589921|imex:IM-8528-4|dip:DIP-57213E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056199.2|refseq:NP_597677.2|refseq:XP_016864819.1|dip:DIP-29199N|ensembl:ENSG00000164190(gene)|ensembl:ENST00000282516(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0001656"(metanephros development)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0007420"(brain development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0032039"(integrator complex)|go:"GO:0032116"(SMC loading complex)|go:"GO:0034087"(establishment of mitotic sister chromatid cohesion)|go:"GO:0034088"(maintenance of mitotic sister chromatid cohesion)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035136"(forelimb morphogenesis)|go:"GO:0035261"(external genitalia morphogenesis)|go:"GO:0036033"(mediator complex binding)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042471"(ear morphogenesis)|go:"GO:0042634"(regulation of hair cycle)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048557"(embryonic digestive tract morphogenesis)|go:"GO:0048565"(digestive tract development)|go:"GO:0048589"(developmental growth)|go:"GO:0048592"(eye morphogenesis)|go:"GO:0048638"(regulation of developmental growth)|go:"GO:0048703"(embryonic viscerocranium morphogenesis)|go:"GO:0050890"(cognition)|go:"GO:0060325"(face morphogenesis)|go:"GO:0061010"(gall bladder development)|go:"GO:0061038"(uterus morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070087"(chromo shadow domain binding)|go:"GO:0071169"(establishment of protein localization to chromatin)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0071921"(cohesin loading)|go:"GO:0090694"(Scc2-Scc4 cohesin loading complex)|go:"GO:1905406"(positive regulation of mitotic cohesin loading)|go:"GO:1990414"(replication-born double-strand break repair via sister chromatid exchange)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2001224"(positive regulation of neuron migration)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026003|interpro:IPR033031|rcsb pdb:6WG3|rcsb pdb:6WGE|reactome:R-HSA-2470946|interpro:IPR024986 refseq:NP_056144.3|ensembl:ENSP00000262815|dip:DIP-29196N|ensembl:ENSG00000129933(gene)|ensembl:ENST00000262815(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0016604"(nuclear body)|go:"GO:0032116"(SMC loading complex)|go:"GO:0034088"(maintenance of mitotic sister chromatid cohesion)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051301"(cell division)|go:"GO:0071921"(cohesin loading)|go:"GO:0090694"(Scc2-Scc4 cohesin loading complex)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019440|interpro:IPR019734|reactome:R-HSA-2470946 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/05 2017/08/10 rogid:RaZLQ4CmlJD/3QUl7n1JKBT23GM9606 rogid:38P0UWq8zlICr3G4DeJShwt8C/c9606 rigid:P+InWRt6NKfW3+1pV8f1TLeBb7k false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:O60216 uniprotkb:Q9UQE7 intact:EBI-80739|ensembl:ENSP00000297338|uniprotkb:Q15001|uniprotkb:Q99568|uniprotkb:A8K0E0 intact:EBI-80718|ensembl:ENSP00000354720|uniprotkb:O60464|uniprotkb:Q5T482|uniprotkb:A8K156 psi-mi:rad21_human(display_long)|uniprotkb:RAD21(gene name)|psi-mi:RAD21(display_short)|uniprotkb:HR21(gene name synonym)|uniprotkb:KIAA0078(gene name synonym)|uniprotkb:Nuclear matrix protein 1(gene name synonym)|uniprotkb:SCC1 homolog(gene name synonym)|uniprotkb:NXP1(gene name synonym)|uniprotkb:SCC1(gene name synonym) psi-mi:smc3_human(display_long)|uniprotkb:SMC3(gene name)|psi-mi:SMC3(display_short)|uniprotkb:BAM(gene name synonym)|uniprotkb:SMC3L1(gene name synonym)|uniprotkb:Chondroitin sulfate proteoglycan 6(gene name synonym)|uniprotkb:Chromosome-associated polypeptide(gene name synonym)|uniprotkb:Basement membrane-associated chondroitin proteoglycan(gene name synonym)|uniprotkb:BMH(gene name synonym)|uniprotkb:CSPG6(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Seitan et al. (2006) pubmed:16802858|doi:10.1371/journal.pbio.0040242|imex:IM-8528 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15589904|imex:IM-8528-1|dip:DIP-57214E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000164754(gene)|ensembl:ENST00000297338(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0000922"(spindle pole)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0008278"(cohesin complex)|go:"GO:0010972"(negative regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0034990"(nuclear mitotic cohesin complex)|go:"GO:0034991"(nuclear meiotic cohesin complex)|go:"GO:0045841"(negative regulation of mitotic metaphase/anaphase transition)|go:"GO:0045876"(positive regulation of sister chromatid cohesion)|go:"GO:0051301"(cell division)|go:"GO:0071168"(protein localization to chromatin)|go:"GO:1990414"(replication-born double-strand break repair via sister chromatid exchange)|interpro:IPR006909(Rad21/Rec8 like protein, C-terminal)|interpro:IPR006910(Rad21/Rec8 like protein, N-terminal)|interpro:IPR023093|interpro:IPR036390|interpro:IPR039781|mint:O60216|rcsb pdb:4PJU|rcsb pdb:6WGE|reactome:R-HSA-1221632|reactome:R-HSA-2467813|rcsb pdb:4PJW|rcsb pdb:4PK7|rcsb pdb:6QNX|rcsb pdb:6RRC|reactome:R-HSA-2468052|rcsb pdb:6RRK|reactome:R-HSA-2470946|rcsb pdb:6WG3|reactome:R-HSA-2500257|reactome:R-HSA-3108214|reactome:R-HSA-9018519|refseq:NP_006256.1|dip:DIP-29201N go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0097431"(mitotic spindle pole)|interpro:IPR003395(RecF/RecN/SMC protein, N-terminal)|interpro:IPR010935(SMCs flexible hinge)|interpro:IPR024704|interpro:IPR027417|interpro:IPR036277|interpro:IPR041741|mint:Q9UQE7|rcsb pdb:6WG3|rcsb pdb:6WG4|rcsb pdb:6WG6|rcsb pdb:6WGE|reactome:R-HSA-1221632|reactome:R-HSA-2467813|reactome:R-HSA-2468052|reactome:R-HSA-2470946|reactome:R-HSA-2500257|reactome:R-HSA-3108214|reactome:R-HSA-9018519|go:"GO:0070840"(dynein complex binding)|ensembl:ENSG00000108055(gene)|ensembl:ENST00000361804(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000800"(lateral element)|go:"GO:0003682"(chromatin binding)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0008278"(cohesin complex)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030893"(meiotic cohesin complex)|go:"GO:0034991"(nuclear meiotic cohesin complex)|go:"GO:0036033"(mediator complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|refseq:NP_005436.1|dip:DIP-29200N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/05 2017/08/10 rogid:9H+Fipb91zQo7ie3YHCL7Ardveo9606 rogid:pUxr+sTtttRzGlqCRz/25woNtrg9606 rigid:DM9D7D2r8f74Eel9chT5ps2ylG8 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q6KC79 uniprotkb:Q9Y6X3 intact:EBI-722767|uniprotkb:Q6KCD6|uniprotkb:Q6N080|uniprotkb:Q6ZT92|uniprotkb:Q7Z2E6|uniprotkb:Q8N4M5|uniprotkb:Q9Y6Y3|uniprotkb:Q9Y6Y4|ensembl:ENSP00000282516 intact:EBI-4395624|uniprotkb:Q66PT1|uniprotkb:Q6P3S7|uniprotkb:Q6ZTT2|uniprotkb:Q9UFX8|intact:EBI-28974208|ensembl:ENSP00000262815 psi-mi:nipbl_human(display_long)|uniprotkb:Delangin(gene name synonym)|uniprotkb:SCC2 homolog(gene name synonym)|uniprotkb:NIPBL(gene name)|psi-mi:NIPBL(display_short)|uniprotkb:IDN3(gene name synonym)|uniprotkb:SCC2(gene name synonym) psi-mi:scc4_human(display_long)|uniprotkb:MAU2(gene name)|psi-mi:MAU2(display_short)|uniprotkb:KIAA0892(gene name synonym)|uniprotkb:SCC4(gene name synonym)|uniprotkb:Cohesin loading complex subunit SCC4 homolog(gene name synonym) psi-mi:"MI:0018"(two hybrid) Seitan et al. (2006) pubmed:16802858|doi:10.1371/journal.pbio.0040242|imex:IM-8528 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15589938|imex:IM-8528-2|dip:DIP-57213E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056199.2|refseq:NP_597677.2|refseq:XP_016864819.1|dip:DIP-29199N|ensembl:ENSG00000164190(gene)|ensembl:ENST00000282516(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0001656"(metanephros development)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0007420"(brain development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0032039"(integrator complex)|go:"GO:0032116"(SMC loading complex)|go:"GO:0034087"(establishment of mitotic sister chromatid cohesion)|go:"GO:0034088"(maintenance of mitotic sister chromatid cohesion)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035136"(forelimb morphogenesis)|go:"GO:0035261"(external genitalia morphogenesis)|go:"GO:0036033"(mediator complex binding)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042471"(ear morphogenesis)|go:"GO:0042634"(regulation of hair cycle)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048557"(embryonic digestive tract morphogenesis)|go:"GO:0048565"(digestive tract development)|go:"GO:0048589"(developmental growth)|go:"GO:0048592"(eye morphogenesis)|go:"GO:0048638"(regulation of developmental growth)|go:"GO:0048703"(embryonic viscerocranium morphogenesis)|go:"GO:0050890"(cognition)|go:"GO:0060325"(face morphogenesis)|go:"GO:0061010"(gall bladder development)|go:"GO:0061038"(uterus morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070087"(chromo shadow domain binding)|go:"GO:0071169"(establishment of protein localization to chromatin)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0071921"(cohesin loading)|go:"GO:0090694"(Scc2-Scc4 cohesin loading complex)|go:"GO:1905406"(positive regulation of mitotic cohesin loading)|go:"GO:1990414"(replication-born double-strand break repair via sister chromatid exchange)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2001224"(positive regulation of neuron migration)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026003|interpro:IPR033031|rcsb pdb:6WG3|rcsb pdb:6WGE|reactome:R-HSA-2470946|interpro:IPR024986 refseq:NP_056144.3|ensembl:ENSP00000262815|dip:DIP-29196N|ensembl:ENSG00000129933(gene)|ensembl:ENST00000262815(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0016604"(nuclear body)|go:"GO:0032116"(SMC loading complex)|go:"GO:0034088"(maintenance of mitotic sister chromatid cohesion)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051301"(cell division)|go:"GO:0071921"(cohesin loading)|go:"GO:0090694"(Scc2-Scc4 cohesin loading complex)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019440|interpro:IPR019734|reactome:R-HSA-2470946 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/05 2017/08/10 rogid:RaZLQ4CmlJD/3QUl7n1JKBT23GM9606 rogid:38P0UWq8zlICr3G4DeJShwt8C/c9606 rigid:P+InWRt6NKfW3+1pV8f1TLeBb7k false sufficient binding region:1-139 sufficient binding region:1-115 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)