#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q8ZMX2	uniprotkb:Q9QXG4	intact:EBI-15588595|ensemblbacteria:AAL21545	intact:EBI-15588558|ensembl:ENSMUSP00000029135|uniprotkb:Q8BK97	psi-mi:lysac_salty(display_long)|uniprotkb:pat(gene name)|psi-mi:pat(display_short)|uniprotkb:yfiQ(gene name synonym)|uniprotkb:STM2651(locus name)|uniprotkb:Protein lysine acetyltransferase(gene name synonym)	psi-mi:acsa_mouse(display_long)|uniprotkb:Acetyl-CoA synthetase 1(gene name synonym)|uniprotkb:Propionate--CoA ligase(gene name synonym)|uniprotkb:Acss2(gene name)|psi-mi:Acss2(display_short)|uniprotkb:Acas2(gene name synonym)|uniprotkb:Acecs1(gene name synonym)|uniprotkb:Acetate--CoA ligase(gene name synonym)|uniprotkb:Acetyl-CoA synthetase(gene name synonym)|uniprotkb:Acyl-CoA synthetase short-chain family member 2(gene name synonym)|uniprotkb:Acyl-activating enzyme(gene name synonym)	psi-mi:"MI:0889"(acetylase assay)	Hallows et al. (2006)	pubmed:16790548|doi:10.1073/pnas.0604392103|imex:IM-23740	taxid:99287(salty)|taxid:99287(Salmonella typhimurium)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0192"(acetylation reaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15588617|imex:IM-23740-1|dip:DIP-197801E	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblbacteria:AAL21545(transcript)|ensemblbacteria:STM2651(gene)|go:"GO:0005524"(ATP binding)|go:"GO:0008080"(N-acetyltransferase activity)|go:"GO:0046872"(metal ion binding)|interpro:IPR000182(GCN5-related N-acetyltransferase)|interpro:IPR003781(CoA-binding)|interpro:IPR011761(ATP-grasp fold)|interpro:IPR013815(ATP-grasp fold, subdomain 1)|interpro:IPR016102(Succinyl-CoA synthetase-like)|interpro:IPR032875|interpro:IPR036291|interpro:IPR016181(Acyl-CoA N-acyltransferase)|refseq:NP_461586.1|refseq:WP_000082639.1|dip:DIP-61211N	ensembl:ENSMUSG00000027605(gene)|ensembl:ENSMUST00000029135(transcript)|go:"GO:0003987"(acetate-CoA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006085"(acetyl-CoA biosynthetic process)|go:"GO:0008610"(lipid biosynthetic process)|go:"GO:0019413"(acetate biosynthetic process)|go:"GO:0019542"(propionate biosynthetic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050218"(propionate-CoA ligase activity)|interpro:IPR000873(AMP-dependent synthetase and ligase)|interpro:IPR020845|interpro:IPR025110|interpro:IPR032387|interpro:IPR042099|reactome:R-MMU-2151201|reactome:R-MMU-71384|refseq:NP_062785.2|dip:DIP-61210N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:qKr3MqsgAeRFZkokIseSNSUmfPQ99287	rogid:JbQ/2+euD3HtY1p3xVTXImm4RIU10090	rigid:tbhLGT5zD6v2EA6YLnU6TCAPpxY	false	-	N-acetylated L-lysine:661-661	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9QXG4	uniprotkb:Q9NTG7	intact:EBI-15588558|ensembl:ENSMUSP00000029135|uniprotkb:Q8BK97	intact:EBI-724621|uniprotkb:Q9Y6E8|ensembl:ENSP00000372191|uniprotkb:B7Z5U6	psi-mi:acsa_mouse(display_long)|uniprotkb:Acetyl-CoA synthetase 1(gene name synonym)|uniprotkb:Propionate--CoA ligase(gene name synonym)|uniprotkb:Acss2(gene name)|psi-mi:Acss2(display_short)|uniprotkb:Acas2(gene name synonym)|uniprotkb:Acecs1(gene name synonym)|uniprotkb:Acetate--CoA ligase(gene name synonym)|uniprotkb:Acetyl-CoA synthetase(gene name synonym)|uniprotkb:Acyl-CoA synthetase short-chain family member 2(gene name synonym)|uniprotkb:Acyl-activating enzyme(gene name synonym)	psi-mi:sir3_human(display_long)|uniprotkb:SIRT3(gene name)|psi-mi:SIRT3(display_short)|uniprotkb:SIR2L3(gene name synonym)|uniprotkb:SIR2-like protein 3(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 3(gene name synonym)	psi-mi:"MI:0406"(deacetylase assay)	Hallows et al. (2006)	pubmed:16790548|doi:10.1073/pnas.0604392103|imex:IM-23740	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0197"(deacetylation reaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15588637|imex:IM-23740-2|dip:DIP-197804E	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000027605(gene)|ensembl:ENSMUST00000029135(transcript)|go:"GO:0003987"(acetate-CoA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006085"(acetyl-CoA biosynthetic process)|go:"GO:0008610"(lipid biosynthetic process)|go:"GO:0019413"(acetate biosynthetic process)|go:"GO:0019542"(propionate biosynthetic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050218"(propionate-CoA ligase activity)|interpro:IPR000873(AMP-dependent synthetase and ligase)|interpro:IPR020845|interpro:IPR025110|interpro:IPR032387|interpro:IPR042099|reactome:R-MMU-2151201|reactome:R-MMU-71384|refseq:NP_062785.2|dip:DIP-61210N	refseq:NP_001017524.1|refseq:NP_036371.1|ensembl:ENSG00000142082(gene)|ensembl:ENST00000382743(transcript)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006476"(protein deacetylation)|go:"GO:0007568"(aging)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009060"(aerobic respiration)|go:"GO:0017136"(NAD-dependent histone deacetylase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034979"(NAD-dependent protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070403"(NAD+ binding)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902553"(positive regulation of catalase activity)|go:"GO:2000304"(positive regulation of ceramide biosynthetic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|go:"GO:0043565"(sequence-specific DNA binding)|rcsb pdb:3GLR|rcsb pdb:3GLS|rcsb pdb:3GLT|rcsb pdb:3GLU|rcsb pdb:4BN4|rcsb pdb:4BN5|rcsb pdb:4BV3|rcsb pdb:4BVB|rcsb pdb:4BVF|rcsb pdb:4BVG|rcsb pdb:4BVH|rcsb pdb:4C78|rcsb pdb:4C7B|rcsb pdb:4FVT|rcsb pdb:4FZ3|rcsb pdb:4HD8|rcsb pdb:4JSR|rcsb pdb:4JT8|rcsb pdb:4JT9|rcsb pdb:4O8Z|rcsb pdb:5BWN|rcsb pdb:5BWO|rcsb pdb:5D7N|rcsb pdb:5H4D|rcsb pdb:5Y4H|rcsb pdb:5YTK|rcsb pdb:5Z93|rcsb pdb:5Z94|rcsb pdb:5ZGC|rcsb pdb:6ISO|reactome:R-HSA-2151201|reactome:R-HSA-9615017|reactome:R-HSA-9617629|rcsb pdb:4BVE|refseq:XP_016872919.1|dip:DIP-46861N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:JbQ/2+euD3HtY1p3xVTXImm4RIU10090	rogid:KGNwfCABi61filBQeIU5v5n51kE9606	rigid:OROhSW1mlixdWDzXiMNS4rgnvRU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q99NB1	uniprotkb:Q8ZMX2	intact:EBI-8346875|intact:MINT-4086737|uniprotkb:Q8K0M6|ensembl:ENSMUSP00000028944	intact:EBI-15588595|ensemblbacteria:AAL21545	psi-mi:acs2l_mouse(display_long)|uniprotkb:Acss1(gene name)|psi-mi:Acss1(display_short)|uniprotkb:Acas2(gene name synonym)|uniprotkb:Acas2l(gene name synonym)|uniprotkb:Acetate--CoA ligase 2(gene name synonym)|uniprotkb:Acetyl-CoA synthetase 2(gene name synonym)|uniprotkb:Acyl-CoA synthetase short-chain family member 1(gene name synonym)|uniprotkb:Propionate--CoA ligase(gene name synonym)	psi-mi:lysac_salty(display_long)|uniprotkb:pat(gene name)|psi-mi:pat(display_short)|uniprotkb:yfiQ(gene name synonym)|uniprotkb:STM2651(locus name)|uniprotkb:Protein lysine acetyltransferase(gene name synonym)	psi-mi:"MI:0889"(acetylase assay)	Hallows et al. (2006)	pubmed:16790548|doi:10.1073/pnas.0604392103|imex:IM-23740	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:99287(salty)|taxid:99287(Salmonella typhimurium)	psi-mi:"MI:0192"(acetylation reaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15588654|imex:IM-23740-3|dip:DIP-197802E	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_542142.1|dip:DIP-61209N|ensembl:ENSMUSG00000027452(gene)|ensembl:ENSMUST00000028944(transcript)|go:"GO:0003987"(acetate-CoA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006085"(acetyl-CoA biosynthetic process)|go:"GO:0016208"(AMP binding)|go:"GO:0019413"(acetate biosynthetic process)|go:"GO:0019427"(acetyl-CoA biosynthetic process from acetate)|go:"GO:0019542"(propionate biosynthetic process)|go:"GO:0050218"(propionate-CoA ligase activity)|interpro:IPR000873(AMP-dependent synthetase and ligase)|interpro:IPR011904(Acetate--CoA ligase)|interpro:IPR020845|interpro:IPR025110|interpro:IPR032387|interpro:IPR042099|mint:Q99NB1|reactome:R-MMU-71384	ensemblbacteria:AAL21545(transcript)|ensemblbacteria:STM2651(gene)|go:"GO:0005524"(ATP binding)|go:"GO:0008080"(N-acetyltransferase activity)|go:"GO:0046872"(metal ion binding)|interpro:IPR000182(GCN5-related N-acetyltransferase)|interpro:IPR003781(CoA-binding)|interpro:IPR011761(ATP-grasp fold)|interpro:IPR013815(ATP-grasp fold, subdomain 1)|interpro:IPR016102(Succinyl-CoA synthetase-like)|interpro:IPR032875|interpro:IPR036291|interpro:IPR016181(Acyl-CoA N-acyltransferase)|refseq:NP_461586.1|refseq:WP_000082639.1|dip:DIP-61211N	psi-mi:"MI:0465"(dip)	function:"Converts acetate to acetyl-CoA so that it can be used for oxidation through the tricarboxylic cycle to produce ATP and CO(2)"|comment:mint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:h3dcddwI6x6n1h9/eQAdHaNuIMA10090	rogid:qKr3MqsgAeRFZkokIseSNSUmfPQ99287	rigid:2P6H2vp9ruEPpkRZdq1TDrPY5uQ	false	N-acetylated L-lysine:635-635	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q9QXG4	uniprotkb:Q96EB6	intact:EBI-15588558|ensembl:ENSMUSP00000029135|uniprotkb:Q8BK97	intact:EBI-1802965|uniprotkb:Q2XNF6|uniprotkb:Q5JVQ0|uniprotkb:Q9GZR9|uniprotkb:Q9Y6F0|ensembl:ENSP00000212015	psi-mi:acsa_mouse(display_long)|uniprotkb:Acetyl-CoA synthetase 1(gene name synonym)|uniprotkb:Propionate--CoA ligase(gene name synonym)|uniprotkb:Acss2(gene name)|psi-mi:Acss2(display_short)|uniprotkb:Acas2(gene name synonym)|uniprotkb:Acecs1(gene name synonym)|uniprotkb:Acetate--CoA ligase(gene name synonym)|uniprotkb:Acetyl-CoA synthetase(gene name synonym)|uniprotkb:Acyl-CoA synthetase short-chain family member 2(gene name synonym)|uniprotkb:Acyl-activating enzyme(gene name synonym)	psi-mi:sir1_human(display_long)|uniprotkb:NAD-dependent protein deacylase sirtuin-1(gene name synonym)|uniprotkb:SIRT1(gene name)|psi-mi:SIRT1(display_short)|uniprotkb:SIR2L1(gene name synonym)|uniprotkb:SIR2-like protein 1(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 1(gene name synonym)	psi-mi:"MI:0406"(deacetylase assay)	Hallows et al. (2006)	pubmed:16790548|doi:10.1073/pnas.0604392103|imex:IM-23740	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0197"(deacetylation reaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15588674|imex:IM-23740-4|dip:DIP-197805E	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000027605(gene)|ensembl:ENSMUST00000029135(transcript)|go:"GO:0003987"(acetate-CoA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006085"(acetyl-CoA biosynthetic process)|go:"GO:0008610"(lipid biosynthetic process)|go:"GO:0019413"(acetate biosynthetic process)|go:"GO:0019542"(propionate biosynthetic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050218"(propionate-CoA ligase activity)|interpro:IPR000873(AMP-dependent synthetase and ligase)|interpro:IPR020845|interpro:IPR025110|interpro:IPR032387|interpro:IPR042099|reactome:R-MMU-2151201|reactome:R-MMU-71384|refseq:NP_062785.2|dip:DIP-61210N	refseq:NP_001135970.1|refseq:NP_036370.2|refseq:NP_001300978.1|dip:DIP-29757N|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:2000774"(positive regulation of cellular senescence)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|mint:Q96EB6|rcsb pdb:4I5I|rcsb pdb:4IF6|rcsb pdb:4IG9|rcsb pdb:4KXQ|rcsb pdb:4ZZH|rcsb pdb:4ZZI|rcsb pdb:4ZZJ|rcsb pdb:5BTR|reactome:R-HSA-3371453|reactome:R-HSA-400253|reactome:R-HSA-427359|reactome:R-HSA-9617629|reactome:R-HSA-9707616|go:"GO:2000757"(negative regulation of peptidyl-lysine acetylation)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006346"(DNA methylation-dependent heterochromatin assembly)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006642"(triglyceride mobilization)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007517"(muscle organ development)|go:"GO:0007569"(cell aging)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010883"(regulation of lipid storage)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0005739"(mitochondrion)|ensembl:ENSG00000096717(gene)|ensembl:ENST00000212015(transcript)|go:"GO:0000012"(single strand break repair)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000183"(rDNA heterochromatin assembly)|go:"GO:0000731"(DNA synthesis involved in DNA repair)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001525"(angiogenesis)|go:"GO:0001542"(ovulation from ovarian follicle)|go:"GO:0001650"(fibrillar center)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002039"(p53 binding)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0000720"(pyrimidine dimer repair by nucleotide-excision repair)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016605"(PML body)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0017136"(NAD-dependent histone deacetylase activity)|go:"GO:0018394"(peptidyl-lysine acetylation)|go:"GO:0019213"(deacetylase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031393"(negative regulation of prostaglandin biosynthetic process)|go:"GO:0031507"(heterochromatin assembly)|go:"GO:0031648"(protein destabilization)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032071"(regulation of endodeoxyribonuclease activity)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032868"(response to insulin)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0033553"(rDNA heterochromatin)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034391"(regulation of smooth muscle cell apoptotic process)|go:"GO:0034979"(NAD-dependent protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0035356"(cellular triglyceride homeostasis)|go:"GO:0035358"(regulation of peroxisome proliferator activated receptor signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0042393"(histone binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042595"(behavioral response to starvation)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043398"(HLH domain binding)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0046969"("NAD-dependent histone deacetylase activity (H3-K9 specific)")|go:"GO:0050872"(white fat cell differentiation)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051097"(negative regulation of helicase activity)|go:"GO:0051152"(positive regulation of smooth muscle cell differentiation)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070403"(NAD+ binding)|go:"GO:0070829"(obsolete heterochromatin maintenance)|go:"GO:0070857"(regulation of bile acid biosynthetic process)|go:"GO:0070914"(UV-damage excision repair)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0044321"(response to leptin)|go:"GO:0071441"(negative regulation of histone H3-K14 acetylation)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071900"(regulation of protein serine/threonine kinase activity)|go:"GO:0090335"(regulation of brown fat cell differentiation)|go:"GO:0090400"(stress-induced premature senescence)|go:"GO:0106230"(protein depropionylation)|go:"GO:0106231"(protein-propionyllysine depropionylase activity)|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1900113"(negative regulation of histone H3-K9 trimethylation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901984"(negative regulation of protein acetylation)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1904179"(positive regulation of adipose tissue development)|go:"GO:1990254"(keratin filament binding)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000111"(positive regulation of macrophage apoptotic process)|go:"GO:2000480"(negative regulation of cAMP-dependent protein kinase activity)|go:"GO:2000481"(positive regulation of cAMP-dependent protein kinase activity)|go:"GO:2000619"(negative regulation of histone H4-K16 acetylation)|go:"GO:2000655"(negative regulation of cellular response to testosterone stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:JbQ/2+euD3HtY1p3xVTXImm4RIU10090	rogid:h3zVepuhRhzlINCluVuAn71Btjc9606	rigid:4GVHNqO2shNaVVzhp7XzzL6ZfLY	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q99NB1	uniprotkb:Q9NTG7	intact:EBI-8346875|intact:MINT-4086737|uniprotkb:Q8K0M6|ensembl:ENSMUSP00000028944	intact:EBI-724621|uniprotkb:Q9Y6E8|ensembl:ENSP00000372191|uniprotkb:B7Z5U6	psi-mi:acs2l_mouse(display_long)|uniprotkb:Acss1(gene name)|psi-mi:Acss1(display_short)|uniprotkb:Acas2(gene name synonym)|uniprotkb:Acas2l(gene name synonym)|uniprotkb:Acetate--CoA ligase 2(gene name synonym)|uniprotkb:Acetyl-CoA synthetase 2(gene name synonym)|uniprotkb:Acyl-CoA synthetase short-chain family member 1(gene name synonym)|uniprotkb:Propionate--CoA ligase(gene name synonym)	psi-mi:sir3_human(display_long)|uniprotkb:SIRT3(gene name)|psi-mi:SIRT3(display_short)|uniprotkb:SIR2L3(gene name synonym)|uniprotkb:SIR2-like protein 3(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 3(gene name synonym)	psi-mi:"MI:0406"(deacetylase assay)	Hallows et al. (2006)	pubmed:16790548|doi:10.1073/pnas.0604392103|imex:IM-23740	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0197"(deacetylation reaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15588691|imex:IM-23740-5|dip:DIP-197803E	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_542142.1|dip:DIP-61209N|ensembl:ENSMUSG00000027452(gene)|ensembl:ENSMUST00000028944(transcript)|go:"GO:0003987"(acetate-CoA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006085"(acetyl-CoA biosynthetic process)|go:"GO:0016208"(AMP binding)|go:"GO:0019413"(acetate biosynthetic process)|go:"GO:0019427"(acetyl-CoA biosynthetic process from acetate)|go:"GO:0019542"(propionate biosynthetic process)|go:"GO:0050218"(propionate-CoA ligase activity)|interpro:IPR000873(AMP-dependent synthetase and ligase)|interpro:IPR011904(Acetate--CoA ligase)|interpro:IPR020845|interpro:IPR025110|interpro:IPR032387|interpro:IPR042099|mint:Q99NB1|reactome:R-MMU-71384	refseq:NP_001017524.1|refseq:NP_036371.1|ensembl:ENSG00000142082(gene)|ensembl:ENST00000382743(transcript)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006476"(protein deacetylation)|go:"GO:0007568"(aging)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009060"(aerobic respiration)|go:"GO:0017136"(NAD-dependent histone deacetylase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034979"(NAD-dependent protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070403"(NAD+ binding)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902553"(positive regulation of catalase activity)|go:"GO:2000304"(positive regulation of ceramide biosynthetic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|go:"GO:0043565"(sequence-specific DNA binding)|rcsb pdb:3GLR|rcsb pdb:3GLS|rcsb pdb:3GLT|rcsb pdb:3GLU|rcsb pdb:4BN4|rcsb pdb:4BN5|rcsb pdb:4BV3|rcsb pdb:4BVB|rcsb pdb:4BVF|rcsb pdb:4BVG|rcsb pdb:4BVH|rcsb pdb:4C78|rcsb pdb:4C7B|rcsb pdb:4FVT|rcsb pdb:4FZ3|rcsb pdb:4HD8|rcsb pdb:4JSR|rcsb pdb:4JT8|rcsb pdb:4JT9|rcsb pdb:4O8Z|rcsb pdb:5BWN|rcsb pdb:5BWO|rcsb pdb:5D7N|rcsb pdb:5H4D|rcsb pdb:5Y4H|rcsb pdb:5YTK|rcsb pdb:5Z93|rcsb pdb:5Z94|rcsb pdb:5ZGC|rcsb pdb:6ISO|reactome:R-HSA-2151201|reactome:R-HSA-9615017|reactome:R-HSA-9617629|rcsb pdb:4BVE|refseq:XP_016872919.1|dip:DIP-46861N	psi-mi:"MI:0465"(dip)	function:"Converts acetate to acetyl-CoA so that it can be used for oxidation through the tricarboxylic cycle to produce ATP and CO(2)"|comment:mint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:h3dcddwI6x6n1h9/eQAdHaNuIMA10090	rogid:KGNwfCABi61filBQeIU5v5n51kE9606	rigid:HKe3Yp6xsiF0cex0zwSi//OBshE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)