#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9NTG7	uniprotkb:Q9NUB1-1	intact:EBI-724621|uniprotkb:Q9Y6E8|ensembl:ENSP00000372191|uniprotkb:B7Z5U6	intact:EBI-15588433|ensembl:ENSP00000316924	psi-mi:sir3_human(display_long)|uniprotkb:SIRT3(gene name)|psi-mi:SIRT3(display_short)|uniprotkb:SIR2L3(gene name synonym)|uniprotkb:SIR2-like protein 3(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 3(gene name synonym)	psi-mi:q9nub1-1(display_long)|uniprotkb:ACSS1(gene name)|psi-mi:ACSS1(display_short)|uniprotkb:ACAS2L(gene name synonym)|uniprotkb:KIAA1846(gene name synonym)|uniprotkb:Acetate--CoA ligase 2(gene name synonym)|uniprotkb:Acetyl-CoA synthetase 2(gene name synonym)|uniprotkb:Acyl-CoA synthetase short-chain family member 1(gene name synonym)|uniprotkb:Propionate--CoA ligase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Schwer et al. (2006)	pubmed:16788062|doi:10.1073/pnas.0603968103|imex:IM-23739	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15588443|imex:IM-23739-1|dip:DIP-197800E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001017524.1|refseq:NP_036371.1|ensembl:ENSG00000142082(gene)|ensembl:ENST00000382743(transcript)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006476"(protein deacetylation)|go:"GO:0007568"(aging)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009060"(aerobic respiration)|go:"GO:0017136"(NAD-dependent histone deacetylase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034979"(NAD-dependent protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070403"(NAD+ binding)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902553"(positive regulation of catalase activity)|go:"GO:2000304"(positive regulation of ceramide biosynthetic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|go:"GO:0043565"(sequence-specific DNA binding)|rcsb pdb:3GLR|rcsb pdb:3GLS|rcsb pdb:3GLT|rcsb pdb:3GLU|rcsb pdb:4BN4|rcsb pdb:4BN5|rcsb pdb:4BV3|rcsb pdb:4BVB|rcsb pdb:4BVF|rcsb pdb:4BVG|rcsb pdb:4BVH|rcsb pdb:4C78|rcsb pdb:4C7B|rcsb pdb:4FVT|rcsb pdb:4FZ3|rcsb pdb:4HD8|rcsb pdb:4JSR|rcsb pdb:4JT8|rcsb pdb:4JT9|rcsb pdb:4O8Z|rcsb pdb:5BWN|rcsb pdb:5BWO|rcsb pdb:5D7N|rcsb pdb:5H4D|rcsb pdb:5Y4H|rcsb pdb:5YTK|rcsb pdb:5Z93|rcsb pdb:5Z94|rcsb pdb:5ZGC|rcsb pdb:6ISO|reactome:R-HSA-2151201|reactome:R-HSA-9615017|reactome:R-HSA-9617629|rcsb pdb:4BVE|refseq:XP_016872919.1|dip:DIP-46861N	ensembl:ENSG00000154930(gene)|ensembl:ENST00000323482(transcript)|intact:EBI-10313831(isoform-parent)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/05	2017/08/10	rogid:KGNwfCABi61filBQeIU5v5n51kE9606	rogid:Z+A3/EcJ41rhi4xeOFci7YBP9u89606	rigid:hUtamD+rU9G5nNolAvZZNyfntqw	false	-	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9NTG7-1	uniprotkb:Q9NUB1-1	intact:EBI-15588464|ensembl:ENSP00000372191	intact:EBI-15588433|ensembl:ENSP00000316924	psi-mi:q9ntg7-1(display_long)|uniprotkb:SIRT3(gene name)|psi-mi:SIRT3(display_short)|uniprotkb:SIR2L3(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 3(gene name synonym)|uniprotkb:SIR2-like protein 3(gene name synonym)	psi-mi:q9nub1-1(display_long)|uniprotkb:ACSS1(gene name)|psi-mi:ACSS1(display_short)|uniprotkb:ACAS2L(gene name synonym)|uniprotkb:KIAA1846(gene name synonym)|uniprotkb:Acetate--CoA ligase 2(gene name synonym)|uniprotkb:Acetyl-CoA synthetase 2(gene name synonym)|uniprotkb:Acyl-CoA synthetase short-chain family member 1(gene name synonym)|uniprotkb:Propionate--CoA ligase(gene name synonym)	psi-mi:"MI:0406"(deacetylase assay)	Schwer et al. (2006)	pubmed:16788062|doi:10.1073/pnas.0603968103|imex:IM-23739	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0197"(deacetylation reaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15588472|imex:IM-23739-2|dip:DIP-197800E	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000142082(gene)|ensembl:ENST00000382743(transcript)|intact:EBI-724621(isoform-parent)	ensembl:ENSG00000154930(gene)|ensembl:ENST00000323482(transcript)|intact:EBI-10313831(isoform-parent)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:KGNwfCABi61filBQeIU5v5n51kE9606	rogid:Z+A3/EcJ41rhi4xeOFci7YBP9u89606	rigid:hUtamD+rU9G5nNolAvZZNyfntqw	false	mutation disrupting interaction rate:248-248|sufficient binding region:102-399	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)