#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q99KQ4 uniprotkb:Q99KQ4 intact:EBI-8316571|ensembl:ENSMUSP00000020886|uniprotkb:Q8C3B5|uniprotkb:Q9JKM0|intact:MINT-4123932 intact:EBI-8316571|ensembl:ENSMUSP00000020886|uniprotkb:Q8C3B5|uniprotkb:Q9JKM0|intact:MINT-4123932 psi-mi:nampt_mouse(display_long)|uniprotkb:Nampt(gene name)|psi-mi:Nampt(display_short)|uniprotkb:Pbef1(gene name synonym)|uniprotkb:Pre-B-cell colony-enhancing factor 1 homolog(gene name synonym)|uniprotkb:Visfatin(gene name synonym) psi-mi:nampt_mouse(display_long)|uniprotkb:Nampt(gene name)|psi-mi:Nampt(display_short)|uniprotkb:Pbef1(gene name synonym)|uniprotkb:Pre-B-cell colony-enhancing factor 1 homolog(gene name synonym)|uniprotkb:Visfatin(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) Wang et al. (2006) pubmed:16783373|imex:IM-8553|doi:10.1038/nsmb1114 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15587962|imex:IM-8553-1|dip:DIP-57236E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000020572(gene)|ensembl:ENSMUST00000020886(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0004514"("nicotinate-nucleotide diphosphorylase (carboxylating) activity")|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007565"(female pregnancy)|go:"GO:0007568"(aging)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009435"(NAD biosynthetic process)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014916"(regulation of lung blood pressure)|go:"GO:0016607"(nuclear speck)|go:"GO:0030054"(cell junction)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047280"(nicotinamide phosphoribosyltransferase activity)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0070997"(neuron death)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905377"(response to D-galactose)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR016471(Nicotinamide phosphoribosyl transferase)|interpro:IPR036068|interpro:IPR041525|interpro:IPR041529|mint:Q99KQ4|rcsb pdb:2GVL|rcsb pdb:2H3B|rcsb pdb:2H3D|reactome:R-MMU-197264|refseq:NP_067499.2|dip:DIP-29217N ensembl:ENSMUSG00000020572(gene)|ensembl:ENSMUST00000020886(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0004514"("nicotinate-nucleotide diphosphorylase (carboxylating) activity")|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007565"(female pregnancy)|go:"GO:0007568"(aging)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009435"(NAD biosynthetic process)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014916"(regulation of lung blood pressure)|go:"GO:0016607"(nuclear speck)|go:"GO:0030054"(cell junction)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047280"(nicotinamide phosphoribosyltransferase activity)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0070997"(neuron death)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905377"(response to D-galactose)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR016471(Nicotinamide phosphoribosyl transferase)|interpro:IPR036068|interpro:IPR041525|interpro:IPR041529|mint:Q99KQ4|rcsb pdb:2GVL|rcsb pdb:2H3B|rcsb pdb:2H3D|reactome:R-MMU-197264|refseq:NP_067499.2|dip:DIP-29217N psi-mi:"MI:0465"(dip) comment:mint|function:Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway comment:mint|function:Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway full coverage:Only protein-protein interactions|curation depth:imex curation taxid:562(ecolx)|taxid:562(Escherichia coli) - 2017/08/05 2017/08/10 rogid:skRuq0lO53/e2q8+4nPgLyO5YkQ10090 rogid:skRuq0lO53/e2q8+4nPgLyO5YkQ10090 rigid:pZPMCrHcTwsza2+Zhv16+7a24Pc false - - - 0 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)