#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O54967	uniprotkb:Q99M51	intact:EBI-7780354|uniprotkb:Q8C2U0|uniprotkb:Q8K0K4|uniprotkb:Q0Z844|intact:UNK-5364208	intact:EBI-642202|uniprotkb:O55032|uniprotkb:Q9Z279|intact:EBI-2642686|intact:EBI-643937|ensembl:ENSMUSP00000112221	psi-mi:ack1_mouse(display_long)|uniprotkb:Tnk2(gene name)|psi-mi:Tnk2(display_short)|uniprotkb:Ack1(gene name synonym)|uniprotkb:Non-receptor protein tyrosine kinase Ack(gene name synonym)|uniprotkb:Tyrosine kinase non-receptor protein 2(gene name synonym)	psi-mi:nck1_mouse(display_long)|uniprotkb:Nck1(gene name)|psi-mi:Nck1(display_short)|uniprotkb:NCK adaptor protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Galisteo et al. (2006)	pubmed:16777958|doi:10.1073/pnas.0603714103|imex:IM-23637	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15587450|imex:IM-23637-1|dip:DIP-197734E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005912"(adherens junction)|go:"GO:0006897"(endocytosis)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007286"(spermatid development)|go:"GO:0016310"(phosphorylation)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0005634"(nucleus)|refseq:NP_001334114.1|mint:O54967|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050699"(WW domain binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0097268"(cytoophidium)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000369"(regulation of clathrin-dependent endocytosis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005524"(ATP binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015116(GTPase binding)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR021619|interpro:IPR030220|interpro:IPR036028|interpro:IPR037085|interpro:IPR009060(UBA-like)|refseq:NP_001103617.1|refseq:NP_058068.2|refseq:NP_001276372.1|dip:DIP-57223N	refseq:NP_035008.2|refseq:XP_006510903.1|ensembl:ENSMUSG00000032475(gene)|ensembl:ENSMUST00000116522(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007015"(actin filament organization)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016477"(cell migration)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0036493"(positive regulation of translation in response to endoplasmic reticulum stress)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0051707"(response to other organism)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0071074"(eukaryotic initiation factor eIF2 binding)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903676"(positive regulation of cap-dependent translational initiation)|go:"GO:1903679"(positive regulation of cap-independent translational initiation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903912"(negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|go:"GO:1990441"(negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR017304(Cytoplasmic, NCK)|interpro:IPR028526|interpro:IPR035562|interpro:IPR035564|interpro:IPR035565|interpro:IPR035882|interpro:IPR036028|interpro:IPR036860|reactome:R-MMU-186763|reactome:R-MMU-202433|reactome:R-MMU-2029482|reactome:R-MMU-373753|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013420|reactome:R-MMU-9013424|reactome:R-MMU-983695|dip:DIP-37524N	psi-mi:"MI:0465"(dip)	comment:mint|function:Downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR. Participates in clathrin-mediated endocytosis. May be involved both in adult synaptic function and plasticity and in brain development	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/05	2017/08/10	rogid:Fjs1n4lyGfkUAZyP2yzBTYm+VzY10090	rogid:uq7YGxP9zh6bhhrOJdJa9D+3O2g10090	rigid:3EH2T8+G0oopoTnk+mZVR4Srq6Q	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O54967	uniprotkb:Q99M51	intact:EBI-7780354|uniprotkb:Q8C2U0|uniprotkb:Q8K0K4|uniprotkb:Q0Z844|intact:UNK-5364208	intact:EBI-642202|uniprotkb:O55032|uniprotkb:Q9Z279|intact:EBI-2642686|intact:EBI-643937|ensembl:ENSMUSP00000112221	psi-mi:ack1_mouse(display_long)|uniprotkb:Tnk2(gene name)|psi-mi:Tnk2(display_short)|uniprotkb:Ack1(gene name synonym)|uniprotkb:Non-receptor protein tyrosine kinase Ack(gene name synonym)|uniprotkb:Tyrosine kinase non-receptor protein 2(gene name synonym)	psi-mi:nck1_mouse(display_long)|uniprotkb:Nck1(gene name)|psi-mi:Nck1(display_short)|uniprotkb:NCK adaptor protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Galisteo et al. (2006)	pubmed:16777958|doi:10.1073/pnas.0603714103|imex:IM-23637	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15587488|imex:IM-23637-3|dip:DIP-197734E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005912"(adherens junction)|go:"GO:0006897"(endocytosis)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007286"(spermatid development)|go:"GO:0016310"(phosphorylation)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0005634"(nucleus)|refseq:NP_001334114.1|mint:O54967|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050699"(WW domain binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0097268"(cytoophidium)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000369"(regulation of clathrin-dependent endocytosis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005524"(ATP binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015116(GTPase binding)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR021619|interpro:IPR030220|interpro:IPR036028|interpro:IPR037085|interpro:IPR009060(UBA-like)|refseq:NP_001103617.1|refseq:NP_058068.2|refseq:NP_001276372.1|dip:DIP-57223N	refseq:NP_035008.2|refseq:XP_006510903.1|ensembl:ENSMUSG00000032475(gene)|ensembl:ENSMUST00000116522(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007015"(actin filament organization)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016477"(cell migration)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0036493"(positive regulation of translation in response to endoplasmic reticulum stress)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0051707"(response to other organism)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0071074"(eukaryotic initiation factor eIF2 binding)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903676"(positive regulation of cap-dependent translational initiation)|go:"GO:1903679"(positive regulation of cap-independent translational initiation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903912"(negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|go:"GO:1990441"(negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR017304(Cytoplasmic, NCK)|interpro:IPR028526|interpro:IPR035562|interpro:IPR035564|interpro:IPR035565|interpro:IPR035882|interpro:IPR036028|interpro:IPR036860|reactome:R-MMU-186763|reactome:R-MMU-202433|reactome:R-MMU-2029482|reactome:R-MMU-373753|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013420|reactome:R-MMU-9013424|reactome:R-MMU-983695|dip:DIP-37524N	psi-mi:"MI:0465"(dip)	comment:mint|function:Downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR. Participates in clathrin-mediated endocytosis. May be involved both in adult synaptic function and plasticity and in brain development	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/05	2017/08/10	rogid:Fjs1n4lyGfkUAZyP2yzBTYm+VzY10090	rogid:uq7YGxP9zh6bhhrOJdJa9D+3O2g10090	rigid:3EH2T8+G0oopoTnk+mZVR4Srq6Q	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O54967	uniprotkb:P16333-1	intact:EBI-7780354|uniprotkb:Q8C2U0|uniprotkb:Q8K0K4|uniprotkb:Q0Z844|intact:UNK-5364208	intact:EBI-15578122|ensembl:ENSP00000417273|ensembl:ENSP00000288986	psi-mi:ack1_mouse(display_long)|uniprotkb:Tnk2(gene name)|psi-mi:Tnk2(display_short)|uniprotkb:Ack1(gene name synonym)|uniprotkb:Non-receptor protein tyrosine kinase Ack(gene name synonym)|uniprotkb:Tyrosine kinase non-receptor protein 2(gene name synonym)	psi-mi:p16333-1(display_long)|uniprotkb:NCK1(gene name)|psi-mi:NCK1(display_short)|uniprotkb:NCK(gene name synonym)|uniprotkb:NCK adaptor protein 1(gene name synonym)|uniprotkb:SH2/SH3 adaptor protein NCK-alpha(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Galisteo et al. (2006)	pubmed:16777958|doi:10.1073/pnas.0603714103|imex:IM-23637	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15587505|imex:IM-23637-4|dip:DIP-197735E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005912"(adherens junction)|go:"GO:0006897"(endocytosis)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007286"(spermatid development)|go:"GO:0016310"(phosphorylation)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0005634"(nucleus)|refseq:NP_001334114.1|mint:O54967|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050699"(WW domain binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0097268"(cytoophidium)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000369"(regulation of clathrin-dependent endocytosis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005524"(ATP binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015116(GTPase binding)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR021619|interpro:IPR030220|interpro:IPR036028|interpro:IPR037085|interpro:IPR009060(UBA-like)|refseq:NP_001103617.1|refseq:NP_058068.2|refseq:NP_001276372.1|dip:DIP-57223N	ensembl:ENST00000288986(transcript)|ensembl:ENST00000481752(transcript)|ensembl:ENSG00000158092(gene)|intact:EBI-389883(isoform-parent)	psi-mi:"MI:0465"(dip)	comment:mint|function:Downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR. Participates in clathrin-mediated endocytosis. May be involved both in adult synaptic function and plasticity and in brain development	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/05	2017/08/10	rogid:Fjs1n4lyGfkUAZyP2yzBTYm+VzY10090	rogid:UzgLYRQQ9VjN7eKkgn76At/7cSA9606	rigid:N3WrS/XMR+Rdb4RE/JErbxpeuiU	false	-	mutation disrupting interaction strength:308-308	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O54967	uniprotkb:O54967	intact:EBI-7780354|uniprotkb:Q8C2U0|uniprotkb:Q8K0K4|uniprotkb:Q0Z844|intact:UNK-5364208	intact:EBI-7780354|uniprotkb:Q8C2U0|uniprotkb:Q8K0K4|uniprotkb:Q0Z844|intact:UNK-5364208	psi-mi:ack1_mouse(display_long)|uniprotkb:Tnk2(gene name)|psi-mi:Tnk2(display_short)|uniprotkb:Ack1(gene name synonym)|uniprotkb:Non-receptor protein tyrosine kinase Ack(gene name synonym)|uniprotkb:Tyrosine kinase non-receptor protein 2(gene name synonym)	psi-mi:ack1_mouse(display_long)|uniprotkb:Tnk2(gene name)|psi-mi:Tnk2(display_short)|uniprotkb:Ack1(gene name synonym)|uniprotkb:Non-receptor protein tyrosine kinase Ack(gene name synonym)|uniprotkb:Tyrosine kinase non-receptor protein 2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Galisteo et al. (2006)	pubmed:16777958|doi:10.1073/pnas.0603714103|imex:IM-23637	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15587467|imex:IM-23637-2|dip:DIP-197736E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005912"(adherens junction)|go:"GO:0006897"(endocytosis)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007286"(spermatid development)|go:"GO:0016310"(phosphorylation)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0005634"(nucleus)|refseq:NP_001334114.1|mint:O54967|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050699"(WW domain binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0097268"(cytoophidium)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000369"(regulation of clathrin-dependent endocytosis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005524"(ATP binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015116(GTPase binding)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR021619|interpro:IPR030220|interpro:IPR036028|interpro:IPR037085|interpro:IPR009060(UBA-like)|refseq:NP_001103617.1|refseq:NP_058068.2|refseq:NP_001276372.1|dip:DIP-57223N	go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005912"(adherens junction)|go:"GO:0006897"(endocytosis)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007286"(spermatid development)|go:"GO:0016310"(phosphorylation)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0005634"(nucleus)|refseq:NP_001334114.1|mint:O54967|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050699"(WW domain binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0097268"(cytoophidium)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000369"(regulation of clathrin-dependent endocytosis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005524"(ATP binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015116(GTPase binding)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR021619|interpro:IPR030220|interpro:IPR036028|interpro:IPR037085|interpro:IPR009060(UBA-like)|refseq:NP_001103617.1|refseq:NP_058068.2|refseq:NP_001276372.1|dip:DIP-57223N	psi-mi:"MI:0465"(dip)	comment:mint|function:Downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR. Participates in clathrin-mediated endocytosis. May be involved both in adult synaptic function and plasticity and in brain development	comment:mint|function:Downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR. Participates in clathrin-mediated endocytosis. May be involved both in adult synaptic function and plasticity and in brain development	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:Fjs1n4lyGfkUAZyP2yzBTYm+VzY10090	rogid:Fjs1n4lyGfkUAZyP2yzBTYm+VzY10090	rigid:q5yVeFiE/s0DUkUaB2tKoUaktHo	false	-	sufficient binding region:395-445|glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O54967	uniprotkb:P16333-1	intact:EBI-7780354|uniprotkb:Q8C2U0|uniprotkb:Q8K0K4|uniprotkb:Q0Z844|intact:UNK-5364208	intact:EBI-15578122|ensembl:ENSP00000417273|ensembl:ENSP00000288986	psi-mi:ack1_mouse(display_long)|uniprotkb:Tnk2(gene name)|psi-mi:Tnk2(display_short)|uniprotkb:Ack1(gene name synonym)|uniprotkb:Non-receptor protein tyrosine kinase Ack(gene name synonym)|uniprotkb:Tyrosine kinase non-receptor protein 2(gene name synonym)	psi-mi:p16333-1(display_long)|uniprotkb:NCK1(gene name)|psi-mi:NCK1(display_short)|uniprotkb:NCK(gene name synonym)|uniprotkb:NCK adaptor protein 1(gene name synonym)|uniprotkb:SH2/SH3 adaptor protein NCK-alpha(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Galisteo et al. (2006)	pubmed:16777958|doi:10.1073/pnas.0603714103|imex:IM-23637	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15587525|imex:IM-23637-5|dip:DIP-197735E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005912"(adherens junction)|go:"GO:0006897"(endocytosis)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007286"(spermatid development)|go:"GO:0016310"(phosphorylation)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0005634"(nucleus)|refseq:NP_001334114.1|mint:O54967|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050699"(WW domain binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0097268"(cytoophidium)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000369"(regulation of clathrin-dependent endocytosis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005524"(ATP binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015116(GTPase binding)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR021619|interpro:IPR030220|interpro:IPR036028|interpro:IPR037085|interpro:IPR009060(UBA-like)|refseq:NP_001103617.1|refseq:NP_058068.2|refseq:NP_001276372.1|dip:DIP-57223N	ensembl:ENST00000288986(transcript)|ensembl:ENST00000481752(transcript)|ensembl:ENSG00000158092(gene)|intact:EBI-389883(isoform-parent)	psi-mi:"MI:0465"(dip)	comment:mint|function:Downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR. Participates in clathrin-mediated endocytosis. May be involved both in adult synaptic function and plasticity and in brain development	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/05	2017/08/10	rogid:Fjs1n4lyGfkUAZyP2yzBTYm+VzY10090	rogid:UzgLYRQQ9VjN7eKkgn76At/7cSA9606	rigid:N3WrS/XMR+Rdb4RE/JErbxpeuiU	false	mutation disrupting interaction strength:158-158	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)