#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9UBK8	uniprotkb:Q99707	intact:EBI-10319161|uniprotkb:O60471|uniprotkb:Q7Z4M8|uniprotkb:Q32MA9|ensembl:ENSP00000402510	intact:EBI-1045782|uniprotkb:Q99713|uniprotkb:Q99723|uniprotkb:A9Z1W4|uniprotkb:B9EGF7|uniprotkb:A1L4N8|uniprotkb:B7ZLW7|ensembl:ENSP00000355536	psi-mi:mtrr_human(display_long)|uniprotkb:MTRR(gene name)|psi-mi:MTRR(display_short)|uniprotkb:Aquacobalamin reductase(gene name synonym)	psi-mi:meth_human(display_long)|uniprotkb:5-methyltetrahydrofolate--homocysteine methyltransferase(gene name synonym)|uniprotkb:Vitamin-B12 dependent methionine synthase(gene name synonym)|uniprotkb:MTR(gene name)|psi-mi:MTR(display_short)|uniprotkb:Cobalamin-dependent methionine synthase(gene name synonym)	psi-mi:"MI:0979"(oxidoreductase assay)	Yamada et al. (2006)	pubmed:16769880|doi:10.1073/pnas.0603694103|imex:IM-23629	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15586485|imex:IM-23629-1|dip:DIP-197724E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002445.2|refseq:NP_076915.2|interpro:IPR003097(FAD-binding, type 1)|interpro:IPR008254(Flavodoxin/nitric oxide synthase)|interpro:IPR017927|interpro:IPR017938|interpro:IPR023173|interpro:IPR029039|interpro:IPR039261|rcsb pdb:2QTL|rcsb pdb:2QTZ|reactome:R-HSA-156581|reactome:R-HSA-1614635|reactome:R-HSA-196741|reactome:R-HSA-3359467|reactome:R-HSA-3359469|ensembl:ENSG00000124275(gene)|ensembl:ENST00000440940(transcript)|go:"GO:0003958"(NADPH-hemoprotein reductase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006306"(DNA methylation)|go:"GO:0009086"(methionine biosynthetic process)|go:"GO:0010181"(FMN binding)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0016709"("oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen")|go:"GO:0016723"(oxidoreductase activity, acting on metal ions, NAD or NADP as acceptor)|go:"GO:0030586"([methionine synthase] reductase activity)|go:"GO:0033353"(S-adenosylmethionine cycle)|go:"GO:0043418"(homocysteine catabolic process)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0046655"(folic acid metabolic process)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0050667"(homocysteine metabolic process)|go:"GO:0070402"(NADPH binding)|go:"GO:0071949"(FAD binding)|go:"GO:1904042"(negative regulation of cystathionine beta-synthase activity)|interpro:IPR001094(Flavodoxin-like)|interpro:IPR001433("Oxidoreductase FAD/NAD(P)-binding")|interpro:IPR001709(Flavoprotein pyridine nucleotide cytochrome reductase)|dip:DIP-61183N	refseq:NP_001278869.1|refseq:NP_000245.2|ensembl:ENSG00000116984(gene)|ensembl:ENST00000366577(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0007399"(nervous system development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008705"(methionine synthase activity)|go:"GO:0009086"(methionine biosynthetic process)|go:"GO:0009235"(cobalamin metabolic process)|go:"GO:0031103"(axon regeneration)|go:"GO:0031419"(cobalamin binding)|go:"GO:0032259"(methylation)|go:"GO:0042558"(pteridine-containing compound metabolic process)|go:"GO:0048678"(response to axon injury)|go:"GO:0071732"(cellular response to nitric oxide)|interpro:IPR000489(Dihydropteroate synthase, DHPS)|interpro:IPR003726(Homocysteine S-methyltransferase)|interpro:IPR003759("Methionine synthase, cobalamin (vitamin B12)-binding module, cap")|interpro:IPR004223(Vitamin B12 dependent methionine synthase, activation region)|interpro:IPR006158("Cobalamin (vitamin B12)-binding")|interpro:IPR011005(Dihydropteroate synthase-like)|interpro:IPR011822(5-methyltetrahydrofolate--homocysteine methyltransferase)|interpro:IPR033706|interpro:IPR036589|interpro:IPR036594|interpro:IPR036724|interpro:IPR037010|rcsb pdb:2O2K|rcsb pdb:4CCZ|reactome:R-HSA-156581|reactome:R-HSA-1614635|reactome:R-HSA-196741|reactome:R-HSA-3359467|reactome:R-HSA-3359469|reactome:R-HSA-9013407|refseq:NP_001278868.1|dip:DIP-40306N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2019/01/24	rogid:BzPSaY4SfI43/tZh7mWlKKtP0Uk9606	rogid:wfY9f5C2d1neO4MQeVdVrVGzrrs9606	rigid:0c3kgQA7T6W/djr/UE/pSBZwfmc	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)