#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P63165 uniprotkb:P63279 intact:EBI-80140|uniprotkb:P55856|uniprotkb:Q6FGG0|uniprotkb:Q6NZ62|uniprotkb:Q93068|intact:EBI-28970052|ensembl:ENSP00000376076|ensembl:ENSP00000376077|uniprotkb:B2R4I5|uniprotkb:A8MUS8 intact:EBI-80168|uniprotkb:P50550|uniprotkb:Q15698|uniprotkb:Q59GX1|uniprotkb:Q86VB3|ensembl:ENSP00000324897|ensembl:ENSP00000348056|ensembl:ENSP00000380649|ensembl:ENSP00000380650|ensembl:ENSP00000384568|ensembl:ENSP00000455893|ensembl:ENSP00000456188|ensembl:ENSP00000457064|ensembl:ENSP00000490882|ensembl:ENSP00000385009|uniprotkb:D3DU69 psi-mi:sumo1_human(display_long)|uniprotkb:SUMO1(gene name)|psi-mi:SUMO1(display_short)|uniprotkb:Sentrin(gene name synonym)|uniprotkb:Ubiquitin-like protein SMT3C(gene name synonym)|uniprotkb:Ubiquitin-homology domain protein PIC1(gene name synonym)|uniprotkb:Ubiquitin-like protein UBL1(gene name synonym)|uniprotkb:GAP-modifying protein 1(gene name synonym)|uniprotkb:SMT3 homolog 3(gene name synonym)|uniprotkb:SMT3C(gene name synonym)|uniprotkb:SMT3H3(gene name synonym)|uniprotkb:UBL1(gene name synonym)|uniprotkb:OK/SW-cl.43(orf name) psi-mi:ubc9_human(display_long)|uniprotkb:UBE2I(gene name)|psi-mi:UBE2I(display_short)|uniprotkb:p18(gene name synonym)|uniprotkb:SUMO-protein ligase(gene name synonym)|uniprotkb:UBC9(gene name synonym)|uniprotkb:UBCE9(gene name synonym)|uniprotkb:Ubiquitin carrier protein 9(gene name synonym)|uniprotkb:Ubiquitin carrier protein I(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2 I(gene name synonym)|uniprotkb:Ubiquitin-protein ligase I(gene name synonym)|uniprotkb:RING-type E3 SUMO transferase UBC9(gene name synonym) psi-mi:"MI:0808"(comigration in sds page) Yunus et al. (2006) pubmed:16732283|doi:10.1038/nsmb1104|imex:IM-8382 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0195"(covalent binding) psi-mi:"MI:0465"(DIP) intact:EBI-15584278|imex:IM-8382-5|dip:DIP-57078E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001005781.1|refseq:NP_003343.1|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031386"(protein tag)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042308"(negative regulation of protein import into nucleus)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0044388"(small protein activating enzyme binding)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0050821"(protein stabilization)|go:"GO:0060021"(roof of mouth development)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0097165"(nuclear stress granule)|go:"GO:1902260"(negative regulation of delayed rectifier potassium channel activity)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR022617|interpro:IPR029071|mint:P63165|rcsb pdb:1A5R|rcsb pdb:1TGZ|rcsb pdb:1WYW|rcsb pdb:1Y8R|rcsb pdb:1Z5S|rcsb pdb:2ASQ|rcsb pdb:2BF8|rcsb pdb:2G4D|rcsb pdb:2IO2|rcsb pdb:2IY0|rcsb pdb:2IY1|rcsb pdb:2KQS|rcsb pdb:2LAS|rcsb pdb:2MW5|rcsb pdb:2N1A|rcsb pdb:2N1V|rcsb pdb:2PE6|rcsb pdb:2UYZ|rcsb pdb:2VRR|rcsb pdb:3KYC|rcsb pdb:3KYD|rcsb pdb:3RZW|rcsb pdb:3UIP|rcsb pdb:4WJN|rcsb pdb:4WJO|rcsb pdb:4WJP|rcsb pdb:4WJQ|rcsb pdb:5AEK|rcsb pdb:5B7A|rcsb pdb:5ELJ|rcsb pdb:5GHD|rcsb pdb:6EOP|rcsb pdb:6EOT|rcsb pdb:6J4I|rcsb pdb:6JXU|rcsb pdb:6JXV|rcsb pdb:6K5T|rcsb pdb:6TRW|rcsb pdb:6UYO|rcsb pdb:6UYP|rcsb pdb:6UYQ|rcsb pdb:6UYR|rcsb pdb:6UYS|ensembl:ENSG00000116030(gene)|ensembl:ENST00000392245(transcript)|ensembl:ENST00000392246(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010621"(negative regulation of transcription by transcription factor localization)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019899"(enzyme binding)|rcsb pdb:6UYU|rcsb pdb:6UYV|rcsb pdb:6UYX|rcsb pdb:6UYY|rcsb pdb:6UYZ|rcsb pdb:6V7P|rcsb pdb:6V7Q|rcsb pdb:6V7R|rcsb pdb:6UYT|rcsb pdb:6V7S|rcsb pdb:6WW3|rcsb pdb:6XOG|rcsb pdb:6XOH|rcsb pdb:6XOI|reactome:R-HSA-3065676|reactome:R-HSA-3065678|reactome:R-HSA-3065679|reactome:R-HSA-3108214|reactome:R-HSA-3108232|reactome:R-HSA-3232118|reactome:R-HSA-3232142|reactome:R-HSA-3899300|reactome:R-HSA-4085377|reactome:R-HSA-4090294|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-4655427|reactome:R-HSA-4755510|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-4551638|reactome:R-HSA-877312|reactome:R-HSA-8866904|reactome:R-HSA-9615933|reactome:R-HSA-9683610|reactome:R-HSA-9694631|ensembl:ENST00000392244|ensembl:ENSP00000376075|ensembl:ENSP00000376076|ensembl:ENSP00000376077|refseq:NP_001005782.1|dip:DIP-29080N refseq:NP_003336.1|refseq:NP_919235.1|refseq:NP_919236.1|refseq:NP_919237.1|ensembl:ENSG00000103275(gene)|rcsb pdb:5D2M|rcsb pdb:5F6D|rcsb pdb:5F6E|rcsb pdb:5F6U|rcsb pdb:5F6V|rcsb pdb:5F6W|rcsb pdb:5F6X|rcsb pdb:5F6Y|rcsb pdb:5FQ2|rcsb pdb:6SYF|reactome:R-HSA-1221632|reactome:R-HSA-196791|reactome:R-HSA-3065678|reactome:R-HSA-3108214|reactome:R-HSA-3108232|reactome:R-HSA-3232118|reactome:R-HSA-3232142|reactome:R-HSA-3899300|reactome:R-HSA-4085377|reactome:R-HSA-4090294|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-4655427|reactome:R-HSA-4755510|reactome:R-HSA-5693565|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-8866904|reactome:R-HSA-9615933|reactome:R-HSA-9683610|reactome:R-HSA-9694631|ensembl:ENST00000325437(transcript)|ensembl:ENST00000355803(transcript)|ensembl:ENST00000397514(transcript)|ensembl:ENST00000397515(transcript)|ensembl:ENST00000403747(transcript)|ensembl:ENST00000406620(transcript)|ensembl:ENST00000562470(transcript)|ensembl:ENST00000566587(transcript)|ensembl:ENST00000567074(transcript)|ensembl:ENST00000567383(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007084"(mitotic nuclear membrane reassembly)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016605"(PML body)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043398"(HLH domain binding)|go:"GO:0044388"(small protein activating enzyme binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0051301"(cell division)|go:"GO:0061656"(SUMO conjugating enzyme activity)|go:"GO:0071535"(RING-like zinc finger domain binding)|go:"GO:1903755"(positive regulation of SUMO transferase activity)|go:"GO:1990356"(sumoylated E2 ligase complex)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|mint:P63279|rcsb pdb:1A3S|rcsb pdb:1KPS|rcsb pdb:1Z5Q|rcsb pdb:1Z5S|rcsb pdb:2GRN|rcsb pdb:2GRO|rcsb pdb:2GRP|rcsb pdb:2GRQ|rcsb pdb:2GRR|rcsb pdb:2O25|rcsb pdb:2PE6|rcsb pdb:2PX9|rcsb pdb:2XWU|rcsb pdb:3A4S|rcsb pdb:3UIN|go:"GO:1990234"(transferase complex)|rcsb pdb:3UIO|rcsb pdb:3UIP|rcsb pdb:4W5V|rcsb pdb:4Y1L|refseq:XP_016879129.1|dip:DIP-29078N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/04 2017/08/10 rogid:mflrn+v4fHL8UdmLodfZBZA6eAQ9606 rogid:VV8ByrWqarJUmpoBqQ9EPZiGpFo9606 rigid:bUJJJhd2pa1absFwgtm/RMXSHfo false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P04637 uniprotkb:P63165 intact:EBI-366083|uniprotkb:Q15086|uniprotkb:Q15087|uniprotkb:Q15088|uniprotkb:Q16535|uniprotkb:Q16807|uniprotkb:Q16808|uniprotkb:Q16809|uniprotkb:Q16810|uniprotkb:Q16811|uniprotkb:Q16848|uniprotkb:Q86UG1|uniprotkb:Q8J016|uniprotkb:Q99659|uniprotkb:Q9BTM4|uniprotkb:Q9HAQ8|uniprotkb:Q9NP68|uniprotkb:Q9NPJ2|uniprotkb:Q9NZD0|uniprotkb:Q9UBI2|uniprotkb:Q9UQ61|ensembl:ENSP00000269305|ensembl:ENSP00000391478|intact:EBI-28980681|uniprotkb:Q2XN98|uniprotkb:Q3LRW1|uniprotkb:Q3LRW2|uniprotkb:Q3LRW3|uniprotkb:Q3LRW4|uniprotkb:Q3LRW5 intact:EBI-80140|uniprotkb:P55856|uniprotkb:Q6FGG0|uniprotkb:Q6NZ62|uniprotkb:Q93068|intact:EBI-28970052|ensembl:ENSP00000376076|ensembl:ENSP00000376077|uniprotkb:B2R4I5|uniprotkb:A8MUS8 psi-mi:p53_human(display_long)|uniprotkb:TP53(gene name)|psi-mi:TP53(display_short)|uniprotkb:P53(gene name synonym)|uniprotkb:Tumor suppressor p53(gene name synonym)|uniprotkb:Phosphoprotein p53(gene name synonym)|uniprotkb:Antigen NY-CO-13(gene name synonym) psi-mi:sumo1_human(display_long)|uniprotkb:SUMO1(gene name)|psi-mi:SUMO1(display_short)|uniprotkb:Sentrin(gene name synonym)|uniprotkb:Ubiquitin-like protein SMT3C(gene name synonym)|uniprotkb:Ubiquitin-homology domain protein PIC1(gene name synonym)|uniprotkb:Ubiquitin-like protein UBL1(gene name synonym)|uniprotkb:GAP-modifying protein 1(gene name synonym)|uniprotkb:SMT3 homolog 3(gene name synonym)|uniprotkb:SMT3C(gene name synonym)|uniprotkb:SMT3H3(gene name synonym)|uniprotkb:UBL1(gene name synonym)|uniprotkb:OK/SW-cl.43(orf name) psi-mi:"MI:0808"(comigration in sds page) Yunus et al. (2006) pubmed:16732283|doi:10.1038/nsmb1104|imex:IM-8382 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0195"(covalent binding) psi-mi:"MI:0465"(DIP) intact:EBI-15584314|imex:IM-8382-1|dip:DIP-57081E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001263624.1|refseq:NP_001263625.1|ensembl:ENSG00000141510(gene)|ensembl:ENST00000269305(transcript)|ensembl:ENST00000445888(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001756"(somitogenesis)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0031497"(chromatin assembly)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034103"(regulation of tissue remodeling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035033"(histone deacetylase regulator activity)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035690"|go:"GO:0035794"(positive regulation of mitochondrial membrane permeability)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0036310"(ATP-dependent DNA/DNA annealing activity)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0002931"(response to ischemia)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0006983"(ER overload response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007369"(gastrulation)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043504"(mitochondrial DNA repair)|go:"GO:0043516"(regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0043621"(protein self-association)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048512"(circadian behavior)|go:"GO:0048539"(bone marrow development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051097"(negative regulation of helicase activity)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062100"(positive regulation of programmed necrotic cell death)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071494"(cellular response to UV-C)|go:"GO:0072331"(signal transduction by p53 class mediator)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0072717"(cellular response to actinomycin D)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090343"(positive regulation of cell aging)|go:"GO:0090399"(replicative senescence)|go:"GO:0090403"(oxidative stress-induced premature senescence)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0097252"(oligodendrocyte apoptotic process)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0140296"(general transcription initiation factor binding)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|go:"GO:1901525"(negative regulation of mitophagy)|go:"GO:1902108"(regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1902253"(regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904024"(negative regulation of glucose catabolic process to lactate via pyruvate)|go:"GO:1905856"(negative regulation of pentose-phosphate shunt)|go:"GO:1990144"(intrinsic apoptotic signaling pathway in response to hypoxia)|go:"GO:1990248"(regulation of transcription from RNA polymerase II promoter in response to DNA damage)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000269"(regulation of fibroblast apoptotic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000772"(regulation of cellular senescence)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|go:"GO:0007569"(cell aging)|go:"GO:0008104"(protein localization)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009299"(mRNA transcription)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009651"(response to salt stress)|go:"GO:0010165"(response to X-ray)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0016032"(viral process)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031065"(positive regulation of histone deacetylation)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013872("p53 transactivation domain (TAD)")|interpro:IPR036674|interpro:IPR040926|rcsb pdb:2ATA|rcsb pdb:2B3G|rcsb pdb:2BIM|rcsb pdb:2BIN|rcsb pdb:2BIO|rcsb pdb:2BIP|rcsb pdb:2AHI|rcsb pdb:2BIQ|rcsb pdb:2F1X|rcsb pdb:2FEJ|rcsb pdb:2FOJ|rcsb pdb:2FOO|rcsb pdb:2GS0|rcsb pdb:2H1L|rcsb pdb:2H2D|rcsb pdb:2H2F|rcsb pdb:2H4F|rcsb pdb:2H4H|rcsb pdb:2H4J|rcsb pdb:2H59|rcsb pdb:2J0Z|rcsb pdb:2J10|rcsb pdb:2J11|rcsb pdb:2J1W|rcsb pdb:2J1X|rcsb pdb:2J1Y|rcsb pdb:2J1Z|rcsb pdb:2J20|rcsb pdb:2J21|rcsb pdb:2K8F|rcsb pdb:2L14|rcsb pdb:2LY4|rcsb pdb:2MEJ|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:2MWY|rcsb pdb:2MZD|rcsb pdb:2OCJ|rcsb pdb:2PCX|rcsb pdb:1A1U|rcsb pdb:1AIE|rcsb pdb:1C26|rcsb pdb:1DT7|rcsb pdb:1GZH|rcsb pdb:1H26|rcsb pdb:1HS5|rcsb pdb:1JSP|rcsb pdb:1KZY|rcsb pdb:1MA3|rcsb pdb:1OLG|rcsb pdb:1OLH|rcsb pdb:1PES|rcsb pdb:1PET|mint:P04637|rcsb pdb:1SAE|rcsb pdb:1SAF|rcsb pdb:1SAK|rcsb pdb:1SAL|rcsb pdb:1TSR|rcsb pdb:1TUP|rcsb pdb:1UOL|rcsb pdb:1XQH|rcsb pdb:1YC5|rcsb pdb:1YCQ|rcsb pdb:1YCR|rcsb pdb:1YCS|rcsb pdb:2AC0|rcsb pdb:2ADY|refseq:NP_000537.3|refseq:NP_001119584.1|refseq:NP_001119585.1|refseq:NP_001119586.1|refseq:NP_001119587.1|refseq:NP_001119588.1|refseq:NP_001119589.1|rcsb pdb:2RUK|rcsb pdb:2VUK|rcsb pdb:3Q06|rcsb pdb:2WGX|rcsb pdb:2X0U|rcsb pdb:2X0V|rcsb pdb:2X0W|rcsb pdb:2XWR|rcsb pdb:2YBG|rcsb pdb:2YDR|rcsb pdb:2Z5S|rcsb pdb:2Z5T|rcsb pdb:3SAK|rcsb pdb:3D05|rcsb pdb:3D06|rcsb pdb:3D07|rcsb pdb:3D08|rcsb pdb:3D09|rcsb pdb:3D0A|rcsb pdb:3DAB|rcsb pdb:3DAC|rcsb pdb:3IGK|rcsb pdb:3IGL|rcsb pdb:3KMD|rcsb pdb:3TG5|rcsb pdb:3KZ8|rcsb pdb:3LW1|rcsb pdb:3OQ5|rcsb pdb:3PDH|rcsb pdb:3Q01|rcsb pdb:3Q05|rcsb pdb:3TS8|rcsb pdb:3ZME|rcsb pdb:4AGM|rcsb pdb:4AGN|rcsb pdb:4AGO|rcsb pdb:4AGP|rcsb pdb:4AGQ|rcsb pdb:4BUZ|rcsb pdb:4BV2|rcsb pdb:4HFZ|rcsb pdb:4HJE|rcsb pdb:4IBQ|rcsb pdb:4IBS|rcsb pdb:4IBT|rcsb pdb:4IBU|rcsb pdb:4IBV|rcsb pdb:4IBW|rcsb pdb:4IBY|rcsb pdb:4IBZ|rcsb pdb:4IJT|rcsb pdb:4KVP|rcsb pdb:4LO9|rcsb pdb:4LOE|rcsb pdb:4LOF|rcsb pdb:4MZI|rcsb pdb:4MZR|rcsb pdb:4QO1|rcsb pdb:4RP6|rcsb pdb:4RP7|rcsb pdb:4X34|rcsb pdb:4XR8|rcsb pdb:4ZZJ|rcsb pdb:5A7B|rcsb pdb:5AB9|rcsb pdb:5ABA|rcsb pdb:4AGL|rcsb pdb:5AOI|rcsb pdb:5AOJ|rcsb pdb:5AOK|rcsb pdb:5AOL|rcsb pdb:5AOM|rcsb pdb:6XRE|rcsb pdb:7BWN|rcsb pdb:7DHY|rcsb pdb:7DHZ|rcsb pdb:7EL4|reactome:R-HSA-111448|reactome:R-HSA-139915|reactome:R-HSA-1912408|reactome:R-HSA-2559580|reactome:R-HSA-2559584|reactome:R-HSA-2559585|reactome:R-HSA-2559586|reactome:R-HSA-3232118|reactome:R-HSA-349425|reactome:R-HSA-390471|reactome:R-HSA-5620971|reactome:R-HSA-5628897|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-5693565|reactome:R-HSA-6785807|reactome:R-HSA-6796648|reactome:R-HSA-6803204|reactome:R-HSA-6803205|reactome:R-HSA-6803207|reactome:R-HSA-6803211|reactome:R-HSA-6804114|reactome:R-HSA-6804115|reactome:R-HSA-6804116|reactome:R-HSA-6804754|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804758|reactome:R-HSA-6804759|reactome:R-HSA-6804760|reactome:R-HSA-6811555|reactome:R-HSA-69473|reactome:R-HSA-69481|reactome:R-HSA-69541|reactome:R-HSA-69895|reactome:R-HSA-8852276|reactome:R-HSA-8853884|reactome:R-HSA-8941855|reactome:R-HSA-8943724|reactome:R-HSA-983231|rcsb pdb:5ECG|rcsb pdb:5G4M|rcsb pdb:5G4N|rcsb pdb:5BUA|rcsb pdb:5G4O|rcsb pdb:5HOU|rcsb pdb:5HP0|rcsb pdb:5HPD|rcsb pdb:5LAP|rcsb pdb:5LGY|rcsb pdb:5MCT|rcsb pdb:5MCU|rcsb pdb:5MCV|rcsb pdb:5MCW|rcsb pdb:5MF7|rcsb pdb:5MG7|rcsb pdb:5MHC|rcsb pdb:5MOC|rcsb pdb:5O1A|rcsb pdb:5O1B|rcsb pdb:5O1C|rcsb pdb:5O1D|rcsb pdb:5O1E|rcsb pdb:5O1F|rcsb pdb:5O1G|rcsb pdb:5O1H|rcsb pdb:5O1I|rcsb pdb:5OL0|rcsb pdb:5UN8|rcsb pdb:5XZC|rcsb pdb:6FF9|rcsb pdb:6FJ5|rcsb pdb:6GGA|rcsb pdb:6GGB|rcsb pdb:6GGC|rcsb pdb:6GGD|rcsb pdb:6GGE|rcsb pdb:6GGF|rcsb pdb:6LHD|rcsb pdb:6R5L|rcsb pdb:6RJZ|rcsb pdb:6RK8|rcsb pdb:6RKI|rcsb pdb:6RKK|rcsb pdb:6RKM|rcsb pdb:6RL3|rcsb pdb:6RL4|rcsb pdb:6RL6|rcsb pdb:6RM5|rcsb pdb:6RM7|rcsb pdb:6RWH|rcsb pdb:6RWI|rcsb pdb:6RWS|rcsb pdb:6RWU|rcsb pdb:6RX2|rcsb pdb:6RZ3|rcsb pdb:6S39|rcsb pdb:6S40|rcsb pdb:6S9Q|rcsb pdb:6SHZ|rcsb pdb:6SI0|rcsb pdb:6SI1|rcsb pdb:6SI2|rcsb pdb:6SI3|rcsb pdb:6SI4|rcsb pdb:6SIN|rcsb pdb:6SIO|rcsb pdb:6SIP|rcsb pdb:6SIQ|rcsb pdb:6SL6|rcsb pdb:6SLV|rcsb pdb:6T58|rcsb pdb:6V4F|rcsb pdb:6V4H|rcsb pdb:6VQO|rcsb pdb:6VR1|rcsb pdb:6VR5|rcsb pdb:6VRM|rcsb pdb:6VRN|rcsb pdb:6W51|rcsb pdb:6S3C|ensembl:ENSP00000269305|ensembl:ENST00000420246|ensembl:ENSP00000391127|ensembl:ENSP00000391478|ensembl:ENST00000455263|ensembl:ENSP00000398846|ensembl:ENST00000504290|ensembl:ENSP00000484409|ensembl:ENST00000504937|ensembl:ENSP00000481179|ensembl:ENST00000510385|ensembl:ENSP00000478499|ensembl:ENST00000610292|ensembl:ENSP00000478219|ensembl:ENST00000610538|ensembl:ENSP00000480868|ensembl:ENST00000619485|ensembl:ENSP00000482537|ensembl:ENST00000620739|ensembl:ENSP00000481638|ensembl:ENST00000622645|ensembl:ENSP00000482222|refseq:NP_001119590.1|refseq:NP_001263626.1|refseq:NP_001263627.1|refseq:NP_001263628.1|refseq:NP_001263689.1|refseq:NP_001263690.1|dip:DIP-368N refseq:NP_001005781.1|refseq:NP_003343.1|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031386"(protein tag)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042308"(negative regulation of protein import into nucleus)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0044388"(small protein activating enzyme binding)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0050821"(protein stabilization)|go:"GO:0060021"(roof of mouth development)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0097165"(nuclear stress granule)|go:"GO:1902260"(negative regulation of delayed rectifier potassium channel activity)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR022617|interpro:IPR029071|mint:P63165|rcsb pdb:1A5R|rcsb pdb:1TGZ|rcsb pdb:1WYW|rcsb pdb:1Y8R|rcsb pdb:1Z5S|rcsb pdb:2ASQ|rcsb pdb:2BF8|rcsb pdb:2G4D|rcsb pdb:2IO2|rcsb pdb:2IY0|rcsb pdb:2IY1|rcsb pdb:2KQS|rcsb pdb:2LAS|rcsb pdb:2MW5|rcsb pdb:2N1A|rcsb pdb:2N1V|rcsb pdb:2PE6|rcsb pdb:2UYZ|rcsb pdb:2VRR|rcsb pdb:3KYC|rcsb pdb:3KYD|rcsb pdb:3RZW|rcsb pdb:3UIP|rcsb pdb:4WJN|rcsb pdb:4WJO|rcsb pdb:4WJP|rcsb pdb:4WJQ|rcsb pdb:5AEK|rcsb pdb:5B7A|rcsb pdb:5ELJ|rcsb pdb:5GHD|rcsb pdb:6EOP|rcsb pdb:6EOT|rcsb pdb:6J4I|rcsb pdb:6JXU|rcsb pdb:6JXV|rcsb pdb:6K5T|rcsb pdb:6TRW|rcsb pdb:6UYO|rcsb pdb:6UYP|rcsb pdb:6UYQ|rcsb pdb:6UYR|rcsb pdb:6UYS|ensembl:ENSG00000116030(gene)|ensembl:ENST00000392245(transcript)|ensembl:ENST00000392246(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010621"(negative regulation of transcription by transcription factor localization)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019899"(enzyme binding)|rcsb pdb:6UYU|rcsb pdb:6UYV|rcsb pdb:6UYX|rcsb pdb:6UYY|rcsb pdb:6UYZ|rcsb pdb:6V7P|rcsb pdb:6V7Q|rcsb pdb:6V7R|rcsb pdb:6UYT|rcsb pdb:6V7S|rcsb pdb:6WW3|rcsb pdb:6XOG|rcsb pdb:6XOH|rcsb pdb:6XOI|reactome:R-HSA-3065676|reactome:R-HSA-3065678|reactome:R-HSA-3065679|reactome:R-HSA-3108214|reactome:R-HSA-3108232|reactome:R-HSA-3232118|reactome:R-HSA-3232142|reactome:R-HSA-3899300|reactome:R-HSA-4085377|reactome:R-HSA-4090294|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-4655427|reactome:R-HSA-4755510|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-4551638|reactome:R-HSA-877312|reactome:R-HSA-8866904|reactome:R-HSA-9615933|reactome:R-HSA-9683610|reactome:R-HSA-9694631|ensembl:ENST00000392244|ensembl:ENSP00000376075|ensembl:ENSP00000376076|ensembl:ENSP00000376077|refseq:NP_001005782.1|dip:DIP-29080N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/04 2017/08/10 rogid:fGN3kSCGIpi/D6d/X5kaB0Xu8/k9606 rogid:mflrn+v4fHL8UdmLodfZBZA6eAQ9606 rigid:qNv2VfkxXgSkvI8x1fYzGK12UaM false sufficient binding region:320-393 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P46060 uniprotkb:P63279 intact:EBI-396091|uniprotkb:Q96JJ2|ensembl:ENSP00000401470|ensembl:ENSP00000348577|ensembl:ENSP00000385866 intact:EBI-80168|uniprotkb:P50550|uniprotkb:Q15698|uniprotkb:Q59GX1|uniprotkb:Q86VB3|ensembl:ENSP00000324897|ensembl:ENSP00000348056|ensembl:ENSP00000380649|ensembl:ENSP00000380650|ensembl:ENSP00000384568|ensembl:ENSP00000455893|ensembl:ENSP00000456188|ensembl:ENSP00000457064|ensembl:ENSP00000490882|ensembl:ENSP00000385009|uniprotkb:D3DU69 psi-mi:ragp1_human(display_long)|uniprotkb:RANGAP1(gene name)|psi-mi:RANGAP1(display_short)|uniprotkb:KIAA1835(gene name synonym)|uniprotkb:SD(gene name synonym) psi-mi:ubc9_human(display_long)|uniprotkb:UBE2I(gene name)|psi-mi:UBE2I(display_short)|uniprotkb:p18(gene name synonym)|uniprotkb:SUMO-protein ligase(gene name synonym)|uniprotkb:UBC9(gene name synonym)|uniprotkb:UBCE9(gene name synonym)|uniprotkb:Ubiquitin carrier protein 9(gene name synonym)|uniprotkb:Ubiquitin carrier protein I(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2 I(gene name synonym)|uniprotkb:Ubiquitin-protein ligase I(gene name synonym)|uniprotkb:RING-type E3 SUMO transferase UBC9(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) Yunus et al. (2006) pubmed:16732283|doi:10.1038/nsmb1104|imex:IM-8382 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15584333|imex:IM-8382-4|dip:DIP-57079E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002874.1|ensembl:ENST00000356244(transcript)|ensembl:ENST00000405486(transcript)|ensembl:ENST00000455915(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0003723"(RNA binding)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0016235"(aggresome)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|refseq:XP_011528596.1|refseq:XP_011528597.1|refseq:NP_001304859.1|go:"GO:0031965"(nuclear membrane)|interpro:IPR009109(Ran-GTPase activating protein 1, C-terminal)|interpro:IPR032675|interpro:IPR036720|mint:P46060|rcsb pdb:1Z5S|rcsb pdb:2GRN|rcsb pdb:2GRO|rcsb pdb:2GRP|rcsb pdb:2GRQ|rcsb pdb:2GRR|rcsb pdb:2IO2|rcsb pdb:2IO3|rcsb pdb:2IY0|rcsb pdb:3UIN|rcsb pdb:3UIO|rcsb pdb:3UIP|rcsb pdb:5D2M|reactome:R-HSA-141444|reactome:R-HSA-165054|reactome:R-HSA-2467813|interpro:IPR001611(Leucine-rich repeat)|reactome:R-HSA-2500257|reactome:R-HSA-3108232|go:"GO:0044614"(nuclear pore cytoplasmic filaments)|go:"GO:0045296"(cadherin binding)|go:"GO:0046826"(negative regulation of protein export from nucleus)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1904117"(cellular response to vasopressin)|go:"GO:1990723"(cytoplasmic periphery of the nuclear pore complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensembl:ENSG00000100401(gene)|refseq:XP_006724352.1|reactome:R-HSA-4615885|refseq:NP_001265580.1|reactome:R-HSA-68877|reactome:R-HSA-9615933|reactome:R-HSA-9648025|reactome:R-HSA-5663220|refseq:XP_016884382.1|refseq:XP_016884383.1|refseq:XP_016884384.1|refseq:XP_016884385.1|refseq:XP_016884386.1|dip:DIP-29079N refseq:NP_003336.1|refseq:NP_919235.1|refseq:NP_919236.1|refseq:NP_919237.1|ensembl:ENSG00000103275(gene)|rcsb pdb:5D2M|rcsb pdb:5F6D|rcsb pdb:5F6E|rcsb pdb:5F6U|rcsb pdb:5F6V|rcsb pdb:5F6W|rcsb pdb:5F6X|rcsb pdb:5F6Y|rcsb pdb:5FQ2|rcsb pdb:6SYF|reactome:R-HSA-1221632|reactome:R-HSA-196791|reactome:R-HSA-3065678|reactome:R-HSA-3108214|reactome:R-HSA-3108232|reactome:R-HSA-3232118|reactome:R-HSA-3232142|reactome:R-HSA-3899300|reactome:R-HSA-4085377|reactome:R-HSA-4090294|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-4655427|reactome:R-HSA-4755510|reactome:R-HSA-5693565|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-8866904|reactome:R-HSA-9615933|reactome:R-HSA-9683610|reactome:R-HSA-9694631|ensembl:ENST00000325437(transcript)|ensembl:ENST00000355803(transcript)|ensembl:ENST00000397514(transcript)|ensembl:ENST00000397515(transcript)|ensembl:ENST00000403747(transcript)|ensembl:ENST00000406620(transcript)|ensembl:ENST00000562470(transcript)|ensembl:ENST00000566587(transcript)|ensembl:ENST00000567074(transcript)|ensembl:ENST00000567383(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007084"(mitotic nuclear membrane reassembly)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016605"(PML body)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043398"(HLH domain binding)|go:"GO:0044388"(small protein activating enzyme binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0051301"(cell division)|go:"GO:0061656"(SUMO conjugating enzyme activity)|go:"GO:0071535"(RING-like zinc finger domain binding)|go:"GO:1903755"(positive regulation of SUMO transferase activity)|go:"GO:1990356"(sumoylated E2 ligase complex)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|mint:P63279|rcsb pdb:1A3S|rcsb pdb:1KPS|rcsb pdb:1Z5Q|rcsb pdb:1Z5S|rcsb pdb:2GRN|rcsb pdb:2GRO|rcsb pdb:2GRP|rcsb pdb:2GRQ|rcsb pdb:2GRR|rcsb pdb:2O25|rcsb pdb:2PE6|rcsb pdb:2PX9|rcsb pdb:2XWU|rcsb pdb:3A4S|rcsb pdb:3UIN|go:"GO:1990234"(transferase complex)|rcsb pdb:3UIO|rcsb pdb:3UIP|rcsb pdb:4W5V|rcsb pdb:4Y1L|refseq:XP_016879129.1|dip:DIP-29078N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/04 2017/08/10 rogid:pUpd+7p5CeAKaRGLo/bXTeiwjiM9606 rogid:VV8ByrWqarJUmpoBqQ9EPZiGpFo9606 rigid:kiYS1fInbf6ZgoEFZHNClxX2jLc false sufficient binding region:419-587 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P63165 uniprotkb:P46060 intact:EBI-80140|uniprotkb:P55856|uniprotkb:Q6FGG0|uniprotkb:Q6NZ62|uniprotkb:Q93068|intact:EBI-28970052|ensembl:ENSP00000376076|ensembl:ENSP00000376077|uniprotkb:B2R4I5|uniprotkb:A8MUS8 intact:EBI-396091|uniprotkb:Q96JJ2|ensembl:ENSP00000401470|ensembl:ENSP00000348577|ensembl:ENSP00000385866 psi-mi:sumo1_human(display_long)|uniprotkb:SUMO1(gene name)|psi-mi:SUMO1(display_short)|uniprotkb:Sentrin(gene name synonym)|uniprotkb:Ubiquitin-like protein SMT3C(gene name synonym)|uniprotkb:Ubiquitin-homology domain protein PIC1(gene name synonym)|uniprotkb:Ubiquitin-like protein UBL1(gene name synonym)|uniprotkb:GAP-modifying protein 1(gene name synonym)|uniprotkb:SMT3 homolog 3(gene name synonym)|uniprotkb:SMT3C(gene name synonym)|uniprotkb:SMT3H3(gene name synonym)|uniprotkb:UBL1(gene name synonym)|uniprotkb:OK/SW-cl.43(orf name) psi-mi:ragp1_human(display_long)|uniprotkb:RANGAP1(gene name)|psi-mi:RANGAP1(display_short)|uniprotkb:KIAA1835(gene name synonym)|uniprotkb:SD(gene name synonym) psi-mi:"MI:0808"(comigration in sds page) Yunus et al. (2006) pubmed:16732283|doi:10.1038/nsmb1104|imex:IM-8382 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0195"(covalent binding) psi-mi:"MI:0465"(DIP) intact:EBI-15584295|imex:IM-8382-2|dip:DIP-57080E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001005781.1|refseq:NP_003343.1|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031386"(protein tag)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042308"(negative regulation of protein import into nucleus)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0044388"(small protein activating enzyme binding)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0050821"(protein stabilization)|go:"GO:0060021"(roof of mouth development)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0097165"(nuclear stress granule)|go:"GO:1902260"(negative regulation of delayed rectifier potassium channel activity)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR022617|interpro:IPR029071|mint:P63165|rcsb pdb:1A5R|rcsb pdb:1TGZ|rcsb pdb:1WYW|rcsb pdb:1Y8R|rcsb pdb:1Z5S|rcsb pdb:2ASQ|rcsb pdb:2BF8|rcsb pdb:2G4D|rcsb pdb:2IO2|rcsb pdb:2IY0|rcsb pdb:2IY1|rcsb pdb:2KQS|rcsb pdb:2LAS|rcsb pdb:2MW5|rcsb pdb:2N1A|rcsb pdb:2N1V|rcsb pdb:2PE6|rcsb pdb:2UYZ|rcsb pdb:2VRR|rcsb pdb:3KYC|rcsb pdb:3KYD|rcsb pdb:3RZW|rcsb pdb:3UIP|rcsb pdb:4WJN|rcsb pdb:4WJO|rcsb pdb:4WJP|rcsb pdb:4WJQ|rcsb pdb:5AEK|rcsb pdb:5B7A|rcsb pdb:5ELJ|rcsb pdb:5GHD|rcsb pdb:6EOP|rcsb pdb:6EOT|rcsb pdb:6J4I|rcsb pdb:6JXU|rcsb pdb:6JXV|rcsb pdb:6K5T|rcsb pdb:6TRW|rcsb pdb:6UYO|rcsb pdb:6UYP|rcsb pdb:6UYQ|rcsb pdb:6UYR|rcsb pdb:6UYS|ensembl:ENSG00000116030(gene)|ensembl:ENST00000392245(transcript)|ensembl:ENST00000392246(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010621"(negative regulation of transcription by transcription factor localization)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019899"(enzyme binding)|rcsb pdb:6UYU|rcsb pdb:6UYV|rcsb pdb:6UYX|rcsb pdb:6UYY|rcsb pdb:6UYZ|rcsb pdb:6V7P|rcsb pdb:6V7Q|rcsb pdb:6V7R|rcsb pdb:6UYT|rcsb pdb:6V7S|rcsb pdb:6WW3|rcsb pdb:6XOG|rcsb pdb:6XOH|rcsb pdb:6XOI|reactome:R-HSA-3065676|reactome:R-HSA-3065678|reactome:R-HSA-3065679|reactome:R-HSA-3108214|reactome:R-HSA-3108232|reactome:R-HSA-3232118|reactome:R-HSA-3232142|reactome:R-HSA-3899300|reactome:R-HSA-4085377|reactome:R-HSA-4090294|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-4655427|reactome:R-HSA-4755510|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-4551638|reactome:R-HSA-877312|reactome:R-HSA-8866904|reactome:R-HSA-9615933|reactome:R-HSA-9683610|reactome:R-HSA-9694631|ensembl:ENST00000392244|ensembl:ENSP00000376075|ensembl:ENSP00000376076|ensembl:ENSP00000376077|refseq:NP_001005782.1|dip:DIP-29080N refseq:NP_002874.1|ensembl:ENST00000356244(transcript)|ensembl:ENST00000405486(transcript)|ensembl:ENST00000455915(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0003723"(RNA binding)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0016235"(aggresome)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|refseq:XP_011528596.1|refseq:XP_011528597.1|refseq:NP_001304859.1|go:"GO:0031965"(nuclear membrane)|interpro:IPR009109(Ran-GTPase activating protein 1, C-terminal)|interpro:IPR032675|interpro:IPR036720|mint:P46060|rcsb pdb:1Z5S|rcsb pdb:2GRN|rcsb pdb:2GRO|rcsb pdb:2GRP|rcsb pdb:2GRQ|rcsb pdb:2GRR|rcsb pdb:2IO2|rcsb pdb:2IO3|rcsb pdb:2IY0|rcsb pdb:3UIN|rcsb pdb:3UIO|rcsb pdb:3UIP|rcsb pdb:5D2M|reactome:R-HSA-141444|reactome:R-HSA-165054|reactome:R-HSA-2467813|interpro:IPR001611(Leucine-rich repeat)|reactome:R-HSA-2500257|reactome:R-HSA-3108232|go:"GO:0044614"(nuclear pore cytoplasmic filaments)|go:"GO:0045296"(cadherin binding)|go:"GO:0046826"(negative regulation of protein export from nucleus)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1904117"(cellular response to vasopressin)|go:"GO:1990723"(cytoplasmic periphery of the nuclear pore complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensembl:ENSG00000100401(gene)|refseq:XP_006724352.1|reactome:R-HSA-4615885|refseq:NP_001265580.1|reactome:R-HSA-68877|reactome:R-HSA-9615933|reactome:R-HSA-9648025|reactome:R-HSA-5663220|refseq:XP_016884382.1|refseq:XP_016884383.1|refseq:XP_016884384.1|refseq:XP_016884385.1|refseq:XP_016884386.1|dip:DIP-29079N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/04 2017/08/10 rogid:mflrn+v4fHL8UdmLodfZBZA6eAQ9606 rogid:pUpd+7p5CeAKaRGLo/bXTeiwjiM9606 rigid:SI2BYjyGy6Q1990r/sfx1/ZKcRA false - sufficient binding region:419-587 - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P46060 uniprotkb:P63279 intact:EBI-396091|uniprotkb:Q96JJ2|ensembl:ENSP00000401470|ensembl:ENSP00000348577|ensembl:ENSP00000385866 intact:EBI-80168|uniprotkb:P50550|uniprotkb:Q15698|uniprotkb:Q59GX1|uniprotkb:Q86VB3|ensembl:ENSP00000324897|ensembl:ENSP00000348056|ensembl:ENSP00000380649|ensembl:ENSP00000380650|ensembl:ENSP00000384568|ensembl:ENSP00000455893|ensembl:ENSP00000456188|ensembl:ENSP00000457064|ensembl:ENSP00000490882|ensembl:ENSP00000385009|uniprotkb:D3DU69 psi-mi:ragp1_human(display_long)|uniprotkb:RANGAP1(gene name)|psi-mi:RANGAP1(display_short)|uniprotkb:KIAA1835(gene name synonym)|uniprotkb:SD(gene name synonym) psi-mi:ubc9_human(display_long)|uniprotkb:UBE2I(gene name)|psi-mi:UBE2I(display_short)|uniprotkb:p18(gene name synonym)|uniprotkb:SUMO-protein ligase(gene name synonym)|uniprotkb:UBC9(gene name synonym)|uniprotkb:UBCE9(gene name synonym)|uniprotkb:Ubiquitin carrier protein 9(gene name synonym)|uniprotkb:Ubiquitin carrier protein I(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2 I(gene name synonym)|uniprotkb:Ubiquitin-protein ligase I(gene name synonym)|uniprotkb:RING-type E3 SUMO transferase UBC9(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Yunus et al. (2006) pubmed:16732283|doi:10.1038/nsmb1104|imex:IM-8382 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15584352|imex:IM-8382-3|dip:DIP-57079E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002874.1|ensembl:ENST00000356244(transcript)|ensembl:ENST00000405486(transcript)|ensembl:ENST00000455915(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0003723"(RNA binding)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0016235"(aggresome)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|refseq:XP_011528596.1|refseq:XP_011528597.1|refseq:NP_001304859.1|go:"GO:0031965"(nuclear membrane)|interpro:IPR009109(Ran-GTPase activating protein 1, C-terminal)|interpro:IPR032675|interpro:IPR036720|mint:P46060|rcsb pdb:1Z5S|rcsb pdb:2GRN|rcsb pdb:2GRO|rcsb pdb:2GRP|rcsb pdb:2GRQ|rcsb pdb:2GRR|rcsb pdb:2IO2|rcsb pdb:2IO3|rcsb pdb:2IY0|rcsb pdb:3UIN|rcsb pdb:3UIO|rcsb pdb:3UIP|rcsb pdb:5D2M|reactome:R-HSA-141444|reactome:R-HSA-165054|reactome:R-HSA-2467813|interpro:IPR001611(Leucine-rich repeat)|reactome:R-HSA-2500257|reactome:R-HSA-3108232|go:"GO:0044614"(nuclear pore cytoplasmic filaments)|go:"GO:0045296"(cadherin binding)|go:"GO:0046826"(negative regulation of protein export from nucleus)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1904117"(cellular response to vasopressin)|go:"GO:1990723"(cytoplasmic periphery of the nuclear pore complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensembl:ENSG00000100401(gene)|refseq:XP_006724352.1|reactome:R-HSA-4615885|refseq:NP_001265580.1|reactome:R-HSA-68877|reactome:R-HSA-9615933|reactome:R-HSA-9648025|reactome:R-HSA-5663220|refseq:XP_016884382.1|refseq:XP_016884383.1|refseq:XP_016884384.1|refseq:XP_016884385.1|refseq:XP_016884386.1|dip:DIP-29079N refseq:NP_003336.1|refseq:NP_919235.1|refseq:NP_919236.1|refseq:NP_919237.1|ensembl:ENSG00000103275(gene)|rcsb pdb:5D2M|rcsb pdb:5F6D|rcsb pdb:5F6E|rcsb pdb:5F6U|rcsb pdb:5F6V|rcsb pdb:5F6W|rcsb pdb:5F6X|rcsb pdb:5F6Y|rcsb pdb:5FQ2|rcsb pdb:6SYF|reactome:R-HSA-1221632|reactome:R-HSA-196791|reactome:R-HSA-3065678|reactome:R-HSA-3108214|reactome:R-HSA-3108232|reactome:R-HSA-3232118|reactome:R-HSA-3232142|reactome:R-HSA-3899300|reactome:R-HSA-4085377|reactome:R-HSA-4090294|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-4655427|reactome:R-HSA-4755510|reactome:R-HSA-5693565|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-8866904|reactome:R-HSA-9615933|reactome:R-HSA-9683610|reactome:R-HSA-9694631|ensembl:ENST00000325437(transcript)|ensembl:ENST00000355803(transcript)|ensembl:ENST00000397514(transcript)|ensembl:ENST00000397515(transcript)|ensembl:ENST00000403747(transcript)|ensembl:ENST00000406620(transcript)|ensembl:ENST00000562470(transcript)|ensembl:ENST00000566587(transcript)|ensembl:ENST00000567074(transcript)|ensembl:ENST00000567383(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007084"(mitotic nuclear membrane reassembly)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016605"(PML body)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043398"(HLH domain binding)|go:"GO:0044388"(small protein activating enzyme binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0051301"(cell division)|go:"GO:0061656"(SUMO conjugating enzyme activity)|go:"GO:0071535"(RING-like zinc finger domain binding)|go:"GO:1903755"(positive regulation of SUMO transferase activity)|go:"GO:1990356"(sumoylated E2 ligase complex)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|mint:P63279|rcsb pdb:1A3S|rcsb pdb:1KPS|rcsb pdb:1Z5Q|rcsb pdb:1Z5S|rcsb pdb:2GRN|rcsb pdb:2GRO|rcsb pdb:2GRP|rcsb pdb:2GRQ|rcsb pdb:2GRR|rcsb pdb:2O25|rcsb pdb:2PE6|rcsb pdb:2PX9|rcsb pdb:2XWU|rcsb pdb:3A4S|rcsb pdb:3UIN|go:"GO:1990234"(transferase complex)|rcsb pdb:3UIO|rcsb pdb:3UIP|rcsb pdb:4W5V|rcsb pdb:4Y1L|refseq:XP_016879129.1|dip:DIP-29078N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/04 2017/08/10 rogid:pUpd+7p5CeAKaRGLo/bXTeiwjiM9606 rogid:VV8ByrWqarJUmpoBqQ9EPZiGpFo9606 rigid:kiYS1fInbf6ZgoEFZHNClxX2jLc false sufficient binding region:419-587 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)