#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q7Z589 uniprotkb:P83916 intact:EBI-6598631|ensembl:ENSP00000334130|ensembl:ENSP00000432327|uniprotkb:Q4G109|uniprotkb:Q8NBU6|uniprotkb:Q8TE50|uniprotkb:Q9H8I9|uniprotkb:Q9NRH0|uniprotkb:B7ZKU0|uniprotkb:B7ZKT8|uniprotkb:B7ZKU2|uniprotkb:Q17RM7 intact:EBI-78129|uniprotkb:P23197|ensembl:ENSP00000225603|ensembl:ENSP00000377060 psi-mi:emsy_human(display_long)|uniprotkb:EMSY(gene name)|psi-mi:EMSY(display_short)|uniprotkb:C11orf30(gene name synonym)|uniprotkb:GL002(orf name) psi-mi:cbx1_human(display_long)|uniprotkb:CBX1(gene name)|psi-mi:CBX1(display_short)|uniprotkb:CBX(gene name synonym)|uniprotkb:Heterochromatin protein 1 homolog beta(gene name synonym)|uniprotkb:Modifier 1 protein(gene name synonym)|uniprotkb:M31(gene name synonym)|uniprotkb:Heterochromatin protein p25(gene name synonym)|uniprotkb:p25beta(gene name synonym)|uniprotkb:HP1Hsbeta(gene name synonym) psi-mi:"MI:0096"(pull down) Huang et al. (2006) pubmed:16615912|doi:10.1016/j.str.2006.01.007|imex:IM-8418 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15579204|imex:IM-8418-2|dip:DIP-57112E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001287871.1|refseq:NP_001287872.1|refseq:NP_001287873.1|ensembl:ENST00000334736(transcript)|ensembl:ENST00000529032(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0042802"(identical protein binding)|interpro:IPR005491(ENT)|interpro:IPR033482|interpro:IPR036142|mint:Q7Z589|rcsb pdb:1UTU|ensembl:ENSG00000158636(gene)|rcsb pdb:1UZ3|rcsb pdb:2FMM|refseq:NP_064578.2|ensembl:ENSP00000433634|ensembl:ENST00000533988|ensembl:ENSP00000434665|ensembl:ENSP00000334130|ensembl:ENST00000524767|ensembl:ENSP00000433205|ensembl:ENST00000525038|ensembl:ENSP00000436968|ensembl:ENST00000525919|ensembl:ENSP00000432010|ensembl:ENSP00000432327|ensembl:ENST00000533248|dip:DIP-29099N ensembl:ENSG00000108468(gene)|ensembl:ENST00000225603(transcript)|ensembl:ENST00000393408(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001939"(female pronucleus)|go:"GO:0001940"(male pronucleus)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005819"(spindle)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010369"(chromocenter)|go:"GO:0019899"(enzyme binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0090734"(site of DNA damage)|go:"GO:1990226"(histone methyltransferase binding)|interpro:IPR000953(Chromo domain)|interpro:IPR008251(Chromo shadow)|interpro:IPR016197(Chromo domain-like)|interpro:IPR017984|interpro:IPR023779|interpro:IPR023780|mint:P83916|rcsb pdb:2FMM|rcsb pdb:3F2U|rcsb pdb:3Q6S|rcsb pdb:5T1G|rcsb pdb:6D07|rcsb pdb:6D08|reactome:R-HSA-9609690|refseq:NP_001120700.1|refseq:NP_006798.1|dip:DIP-28135N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/04 2017/08/10 rogid:AlagiKsle+RG5HUine4x/QddsJc9606 rogid:W2npW/vFRcuTkStKpknsAP69q6I9606 rigid:yl/NiIgHMp+nIwCaG+8kBtzobEc false sufficient binding region:9-139 sufficient binding region:104-175|tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q7Z589 uniprotkb:P83916 intact:EBI-6598631|ensembl:ENSP00000334130|ensembl:ENSP00000432327|uniprotkb:Q4G109|uniprotkb:Q8NBU6|uniprotkb:Q8TE50|uniprotkb:Q9H8I9|uniprotkb:Q9NRH0|uniprotkb:B7ZKU0|uniprotkb:B7ZKT8|uniprotkb:B7ZKU2|uniprotkb:Q17RM7 intact:EBI-78129|uniprotkb:P23197|ensembl:ENSP00000225603|ensembl:ENSP00000377060 psi-mi:emsy_human(display_long)|uniprotkb:EMSY(gene name)|psi-mi:EMSY(display_short)|uniprotkb:C11orf30(gene name synonym)|uniprotkb:GL002(orf name) psi-mi:cbx1_human(display_long)|uniprotkb:CBX1(gene name)|psi-mi:CBX1(display_short)|uniprotkb:CBX(gene name synonym)|uniprotkb:Heterochromatin protein 1 homolog beta(gene name synonym)|uniprotkb:Modifier 1 protein(gene name synonym)|uniprotkb:M31(gene name synonym)|uniprotkb:Heterochromatin protein p25(gene name synonym)|uniprotkb:p25beta(gene name synonym)|uniprotkb:HP1Hsbeta(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) Huang et al. (2006) pubmed:16615912|doi:10.1016/j.str.2006.01.007|imex:IM-8418 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15579227|imex:IM-8418-1|dip:DIP-57112E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001287871.1|refseq:NP_001287872.1|refseq:NP_001287873.1|ensembl:ENST00000334736(transcript)|ensembl:ENST00000529032(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0042802"(identical protein binding)|interpro:IPR005491(ENT)|interpro:IPR033482|interpro:IPR036142|mint:Q7Z589|rcsb pdb:1UTU|ensembl:ENSG00000158636(gene)|rcsb pdb:1UZ3|rcsb pdb:2FMM|refseq:NP_064578.2|ensembl:ENSP00000433634|ensembl:ENST00000533988|ensembl:ENSP00000434665|ensembl:ENSP00000334130|ensembl:ENST00000524767|ensembl:ENSP00000433205|ensembl:ENST00000525038|ensembl:ENSP00000436968|ensembl:ENST00000525919|ensembl:ENSP00000432010|ensembl:ENSP00000432327|ensembl:ENST00000533248|dip:DIP-29099N ensembl:ENSG00000108468(gene)|ensembl:ENST00000225603(transcript)|ensembl:ENST00000393408(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001939"(female pronucleus)|go:"GO:0001940"(male pronucleus)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005819"(spindle)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010369"(chromocenter)|go:"GO:0019899"(enzyme binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0090734"(site of DNA damage)|go:"GO:1990226"(histone methyltransferase binding)|interpro:IPR000953(Chromo domain)|interpro:IPR008251(Chromo shadow)|interpro:IPR016197(Chromo domain-like)|interpro:IPR017984|interpro:IPR023779|interpro:IPR023780|mint:P83916|rcsb pdb:2FMM|rcsb pdb:3F2U|rcsb pdb:3Q6S|rcsb pdb:5T1G|rcsb pdb:6D07|rcsb pdb:6D08|reactome:R-HSA-9609690|refseq:NP_001120700.1|refseq:NP_006798.1|dip:DIP-28135N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/04 2017/08/10 rogid:AlagiKsle+RG5HUine4x/QddsJc9606 rogid:W2npW/vFRcuTkStKpknsAP69q6I9606 rigid:yl/NiIgHMp+nIwCaG+8kBtzobEc false sufficient binding region:9-139 sufficient binding region:104-175 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q7Z589 uniprotkb:P83916 intact:EBI-6598631|ensembl:ENSP00000334130|ensembl:ENSP00000432327|uniprotkb:Q4G109|uniprotkb:Q8NBU6|uniprotkb:Q8TE50|uniprotkb:Q9H8I9|uniprotkb:Q9NRH0|uniprotkb:B7ZKU0|uniprotkb:B7ZKT8|uniprotkb:B7ZKU2|uniprotkb:Q17RM7 intact:EBI-78129|uniprotkb:P23197|ensembl:ENSP00000225603|ensembl:ENSP00000377060 psi-mi:emsy_human(display_long)|uniprotkb:EMSY(gene name)|psi-mi:EMSY(display_short)|uniprotkb:C11orf30(gene name synonym)|uniprotkb:GL002(orf name) psi-mi:cbx1_human(display_long)|uniprotkb:CBX1(gene name)|psi-mi:CBX1(display_short)|uniprotkb:CBX(gene name synonym)|uniprotkb:Heterochromatin protein 1 homolog beta(gene name synonym)|uniprotkb:Modifier 1 protein(gene name synonym)|uniprotkb:M31(gene name synonym)|uniprotkb:Heterochromatin protein p25(gene name synonym)|uniprotkb:p25beta(gene name synonym)|uniprotkb:HP1Hsbeta(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Huang et al. (2006) pubmed:16615912|doi:10.1016/j.str.2006.01.007|imex:IM-8418 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15579248|imex:IM-8418-3|dip:DIP-57112E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001287871.1|refseq:NP_001287872.1|refseq:NP_001287873.1|ensembl:ENST00000334736(transcript)|ensembl:ENST00000529032(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0042802"(identical protein binding)|interpro:IPR005491(ENT)|interpro:IPR033482|interpro:IPR036142|mint:Q7Z589|rcsb pdb:1UTU|ensembl:ENSG00000158636(gene)|rcsb pdb:1UZ3|rcsb pdb:2FMM|refseq:NP_064578.2|ensembl:ENSP00000433634|ensembl:ENST00000533988|ensembl:ENSP00000434665|ensembl:ENSP00000334130|ensembl:ENST00000524767|ensembl:ENSP00000433205|ensembl:ENST00000525038|ensembl:ENSP00000436968|ensembl:ENST00000525919|ensembl:ENSP00000432010|ensembl:ENSP00000432327|ensembl:ENST00000533248|dip:DIP-29099N ensembl:ENSG00000108468(gene)|ensembl:ENST00000225603(transcript)|ensembl:ENST00000393408(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001939"(female pronucleus)|go:"GO:0001940"(male pronucleus)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005819"(spindle)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010369"(chromocenter)|go:"GO:0019899"(enzyme binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0090734"(site of DNA damage)|go:"GO:1990226"(histone methyltransferase binding)|interpro:IPR000953(Chromo domain)|interpro:IPR008251(Chromo shadow)|interpro:IPR016197(Chromo domain-like)|interpro:IPR017984|interpro:IPR023779|interpro:IPR023780|mint:P83916|rcsb pdb:2FMM|rcsb pdb:3F2U|rcsb pdb:3Q6S|rcsb pdb:5T1G|rcsb pdb:6D07|rcsb pdb:6D08|reactome:R-HSA-9609690|refseq:NP_001120700.1|refseq:NP_006798.1|dip:DIP-28135N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/04 2017/08/10 rogid:AlagiKsle+RG5HUine4x/QddsJc9606 rogid:W2npW/vFRcuTkStKpknsAP69q6I9606 rigid:yl/NiIgHMp+nIwCaG+8kBtzobEc false sufficient binding region:9-139 sufficient binding region:104-175 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)