#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q27934	uniprotkb:P61092	intact:EBI-77033|uniprotkb:Q9V721|uniprotkb:C0PV22|ensemblmetazoa:FBpp0086645	intact:EBI-446761|uniprotkb:Q06984|ensembl:ENSMUSP00000044123	psi-mi:phyl_drome(display_long)|uniprotkb:phyl(gene name)|psi-mi:phyl(display_short)|uniprotkb:CG10108(orf name)	psi-mi:sia1a_mouse(display_long)|uniprotkb:Seven in absentia homolog 1a(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase SIAH1A(gene name synonym)|uniprotkb:Siah1a(gene name)|psi-mi:Siah1a(display_short)	psi-mi:"MI:0114"(x-ray crystallography)	House et al. (2006)	pubmed:16615911|doi:10.1016/j.str.2005.12.013|imex:IM-8419	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15579139|imex:IM-8419-2|dip:DIP-57113E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_725394.1|flybase:FBgn0013725|dip:DIP-29101N|ensemblmetazoa:FBgn0013725(gene)|ensemblmetazoa:FBtr0087516(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007423"(sensory organ development)|go:"GO:0007462"(R1/R6 cell fate commitment)|go:"GO:0007465"(R7 cell fate commitment)|go:"GO:0007601"(visual perception)|go:"GO:0008052"(sensory organ boundary specification)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016360"(sensory organ precursor cell fate determination)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035883"(enteroendocrine cell differentiation)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045500"(sevenless signaling pathway)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|rcsb pdb:4I7B|rcsb pdb:4I7C|rcsb pdb:4I7D	refseq:NP_033198.1|refseq:XP_006530847.2|dip:DIP-29100N|ensembl:ENSMUSG00000036840(gene)|ensembl:ENSMUST00000045296(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007141"(male meiosis I)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|go:"GO:0005886"(plasma membrane)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR004162(Seven in absentia protein)|interpro:IPR008974(TRAF-like)|interpro:IPR013010(Zinc finger, SIAH-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018121|rcsb pdb:1K2F|rcsb pdb:2AN6|reactome:R-MMU-373752|reactome:R-MMU-983168	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/04	2017/08/10	rogid:QocGYm5CUc0c4Z8raybzOGhpt1M7227	rogid:C7i3ubOqLVDW4MzmA6OLDZq2TM810090	rigid:XvaUpHV90M0hfRCpCvcwcppu1gM	false	sufficient binding region:107-130	sufficient binding region:92-282	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q27934	uniprotkb:P61092	intact:EBI-77033|uniprotkb:Q9V721|uniprotkb:C0PV22|ensemblmetazoa:FBpp0086645	intact:EBI-446761|uniprotkb:Q06984|ensembl:ENSMUSP00000044123	psi-mi:phyl_drome(display_long)|uniprotkb:phyl(gene name)|psi-mi:phyl(display_short)|uniprotkb:CG10108(orf name)	psi-mi:sia1a_mouse(display_long)|uniprotkb:Seven in absentia homolog 1a(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase SIAH1A(gene name synonym)|uniprotkb:Siah1a(gene name)|psi-mi:Siah1a(display_short)	psi-mi:"MI:0096"(pull down)	House et al. (2006)	pubmed:16615911|doi:10.1016/j.str.2005.12.013|imex:IM-8419	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15579160|imex:IM-8419-1|dip:DIP-57113E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_725394.1|flybase:FBgn0013725|dip:DIP-29101N|ensemblmetazoa:FBgn0013725(gene)|ensemblmetazoa:FBtr0087516(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007423"(sensory organ development)|go:"GO:0007462"(R1/R6 cell fate commitment)|go:"GO:0007465"(R7 cell fate commitment)|go:"GO:0007601"(visual perception)|go:"GO:0008052"(sensory organ boundary specification)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016360"(sensory organ precursor cell fate determination)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035883"(enteroendocrine cell differentiation)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045500"(sevenless signaling pathway)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|rcsb pdb:4I7B|rcsb pdb:4I7C|rcsb pdb:4I7D	refseq:NP_033198.1|refseq:XP_006530847.2|dip:DIP-29100N|ensembl:ENSMUSG00000036840(gene)|ensembl:ENSMUST00000045296(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007141"(male meiosis I)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|go:"GO:0005886"(plasma membrane)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR004162(Seven in absentia protein)|interpro:IPR008974(TRAF-like)|interpro:IPR013010(Zinc finger, SIAH-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018121|rcsb pdb:1K2F|rcsb pdb:2AN6|reactome:R-MMU-373752|reactome:R-MMU-983168	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/04	2017/08/10	rogid:QocGYm5CUc0c4Z8raybzOGhpt1M7227	rogid:C7i3ubOqLVDW4MzmA6OLDZq2TM810090	rigid:XvaUpHV90M0hfRCpCvcwcppu1gM	false	sufficient binding region:107-130|tag:n-n	sufficient binding region:92-282|mutation disrupting interaction:180-180|mutation disrupting interaction strength:158-158	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)