#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:O95292 uniprotkb:O15503-1 intact:EBI-1188298|uniprotkb:O95293|uniprotkb:Q9P0H0|uniprotkb:A2A2F2|ensembl:ENSP00000417175 intact:EBI-15578782|ensembl:ENSP00000344741 psi-mi:vapb_human(display_long)|uniprotkb:VAPB(gene name)|psi-mi:VAPB(display_short)|uniprotkb:UNQ484/PRO983(orf name) psi-mi:o15503-1(display_long)|uniprotkb:INSIG1(gene name)|psi-mi:INSIG1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gong et al. (2006) pubmed:16606821|doi:10.1073/pnas.0601923103|imex:IM-23486 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15578787|imex:IM-23486-1|dip:DIP-197617E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001182606.1|refseq:NP_004729.1|ensembl:ENSG00000124164(gene)|ensembl:ENST00000475243(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0008017"(microtubule binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0019899"(enzyme binding)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0033149"(FFAT motif binding)|go:"GO:0036498"(IRE1-mediated unfolded protein response)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044790"(suppression of viral release by host)|go:"GO:0044791"(obsolete positive regulation by host of viral release from host cell)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045296"(cadherin binding)|go:"GO:0046725"(negative regulation by virus of viral protein levels in host cell)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0061817"(endoplasmic reticulum-plasma membrane tethering)|go:"GO:0090114"(COPII-coated vesicle budding)|go:"GO:0090158"(endoplasmic reticulum membrane organization)|interpro:IPR000535(Major sperm protein)|interpro:IPR008962(PapD-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016763(Vesicle-associated membrane protein)|mint:O95292|rcsb pdb:2MDK|rcsb pdb:3IKK|reactome:R-HSA-1660661|reactome:R-HSA-8980692|reactome:R-HSA-9013106|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|dip:DIP-39816N ensembl:ENSG00000186480(gene)|ensembl:ENST00000340368(transcript)|intact:EBI-6252425(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10029(crigr)|taxid:10029("Cricetulus griseus (Chinese hamster)") - 2017/08/04 2017/08/10 rogid:+TuApjAmnGF1UZonXIsrPaIN4Ak9606 rogid:CePNtn7b6ienEbjTcmzRblg0FnE9606 rigid:HZ9Peg/RuUPKg6L617syN/0vutM false ha tag:c-c myc tag:?-? - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P97260 uniprotkb:O15503-1 intact:EBI-11508251|uniprotkb:Q2WEK9 intact:EBI-15578782|ensembl:ENSP00000344741 psi-mi:scap_crigr(display_long)|uniprotkb:SCAP(gene name)|psi-mi:SCAP(display_short) psi-mi:o15503-1(display_long)|uniprotkb:INSIG1(gene name)|psi-mi:INSIG1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gong et al. (2006) pubmed:16606821|doi:10.1073/pnas.0601923103|imex:IM-23486 taxid:10029(crigr)|taxid:10029("Cricetulus griseus (Chinese hamster)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15578810|imex:IM-23486-2|dip:DIP-197615E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001230965.1|go:"GO:0000139"(Golgi membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0030120"(vesicle coat)|go:"GO:0032933"(SREBP signaling pathway)|go:"GO:0032934"(sterol binding)|go:"GO:0032936"(SREBP-SCAP complex)|go:"GO:0032937"(SREBP-SCAP-Insig complex)|go:"GO:0036315"(cellular response to sterol)|go:"GO:0090110"(COPII-coated vesicle cargo loading)|interpro:IPR000731(Sterol-sensing 5TM box)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR030225|interpro:IPR036322|go:"GO:0008203"(cholesterol metabolic process)|dip:DIP-60914N ensembl:ENSG00000186480(gene)|ensembl:ENST00000340368(transcript)|intact:EBI-6252425(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10029(crigr)|taxid:10029("Cricetulus griseus (Chinese hamster)") - 2017/08/04 2017/08/10 rogid:QoHuAk4vAFqw3/i2H8XKda01FYs10029 rogid:CePNtn7b6ienEbjTcmzRblg0FnE9606 rigid:dPoEWx1QFjh1MuXKDRcbArabZew false - mutation disrupting interaction strength:205-205|myc tag:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9P0L0 uniprotkb:O15503-1 intact:EBI-1059156|uniprotkb:Q9UBZ2|uniprotkb:O75453|uniprotkb:Q5U0E7|intact:EBI-2556404|uniprotkb:A6NDZ0|intact:EBI-2512000|uniprotkb:D3DUI3|ensembl:ENSP00000382880 intact:EBI-15578782|ensembl:ENSP00000344741 psi-mi:vapa_human(display_long)|uniprotkb:VAPA(gene name)|psi-mi:VAPA(display_short)|uniprotkb:VAP33(gene name synonym)|uniprotkb:33 kDa VAMP-associated protein(gene name synonym) psi-mi:o15503-1(display_long)|uniprotkb:INSIG1(gene name)|psi-mi:INSIG1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gong et al. (2006) pubmed:16606821|doi:10.1073/pnas.0601923103|imex:IM-23486 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15578834|imex:IM-23486-3|dip:DIP-197616E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003565.4|refseq:NP_919415.2|dip:DIP-41135N|go:"GO:0031982"(vesicle)|go:"GO:0033149"(FFAT motif binding)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044791"(obsolete positive regulation by host of viral release from host cell)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045296"(cadherin binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0061025"(membrane fusion)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0090114"(COPII-coated vesicle budding)|interpro:IPR000535(Major sperm protein)|interpro:IPR008962(PapD-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016763(Vesicle-associated membrane protein)|mint:Q9P0L0|rcsb pdb:2RR3|rcsb pdb:6TQR|reactome:R-HSA-1660661|reactome:R-HSA-6798695|reactome:R-HSA-9609523|ensembl:ENSG00000101558(gene)|ensembl:ENST00000400000(transcript)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0031965"(nuclear membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0008017"(microtubule binding)|go:"GO:0008219"(cell death)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016021"(integral component of membrane) ensembl:ENSG00000186480(gene)|ensembl:ENST00000340368(transcript)|intact:EBI-6252425(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10029(crigr)|taxid:10029("Cricetulus griseus (Chinese hamster)") - 2017/08/04 2017/08/10 rogid:h8NG5Ak0n6b/iq2yKYMsLsJKpos9606 rogid:CePNtn7b6ienEbjTcmzRblg0FnE9606 rigid:BJ7b4rIreVU/TivKr+w8XY6dV8I false ha tag:c-c myc tag:?-? - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)