#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P01375	uniprotkb:P0DSV7	intact:EBI-359977|uniprotkb:O43647|uniprotkb:Q9P1Q2|uniprotkb:Q9UIV3|ensembl:ENSP00000365290|ensembl:ENSP00000372988|ensembl:ENSP00000389490|ensembl:ENSP00000389492|ensembl:ENSP00000392858|ensembl:ENSP00000398698|ensembl:ENSP00000410668	intact:EBI-15577099|uniprotkb:Q85407|uniprotkb:Q89098|uniprotkb:Q89118|uniprotkb:P34015	psi-mi:tnfa_human(display_long)|uniprotkb:TNF(gene name)|psi-mi:TNF(display_short)|uniprotkb:TNFA(gene name synonym)|uniprotkb:TNFSF2(gene name synonym)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)	psi-mi:crmb_var67(display_long)|uniprotkb:CRMB(gene name)|psi-mi:CRMB(display_short)|uniprotkb:Viral tumor necrosis factor receptor II(gene name synonym)|uniprotkb:G2R(orf name)|uniprotkb:G4R(orf name)	psi-mi:"MI:0107"(surface plasmon resonance)	Alejo et al. (2006)	pubmed:16581912|doi:10.1073/pnas.0510462103|imex:IM-23475	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:587200(varv)|taxid:587200("Variola virus (isolate Human/India/Ind3/1967)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15577120|imex:IM-23475-1|dip:DIP-197575E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204490(gene)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050890"(cognition)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0002020"(protease binding)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007254"(JNK cascade)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009615"(response to virus)|go:"GO:0009651"(response to salt stress)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|ensembl:ENSG00000206439(gene)|ensembl:ENSG00000223952(gene)|ensembl:ENSG00000228321(gene)|ensembl:ENSG00000228849(gene)|ensembl:ENSG00000230108(gene)|ensembl:ENSG00000232810(gene)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|ensembl:ENST00000376122(transcript)|ensembl:ENST00000383496(transcript)|ensembl:ENST00000412275(transcript)|ensembl:ENST00000420425(transcript)|ensembl:ENST00000443707(transcript)|ensembl:ENST00000448781(transcript)|ensembl:ENST00000449264(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045598"(regulation of fat cell differentiation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|reactome:R-HSA-75893|reactome:R-HSA-6785807|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071677"(positive regulation of mononuclear cell migration)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|mint:P01375|rcsb pdb:1A8M|rcsb pdb:1TNF|rcsb pdb:2AZ5|rcsb pdb:2E7A|rcsb pdb:2TUN|rcsb pdb:2ZJC|rcsb pdb:2ZPX|rcsb pdb:3ALQ|rcsb pdb:3IT8|rcsb pdb:3L9J|rcsb pdb:3WD5|rcsb pdb:4G3Y|rcsb pdb:4TSV|rcsb pdb:4TWT|rcsb pdb:4Y6O|rcsb pdb:5M2I|rcsb pdb:5M2J|rcsb pdb:5M2M|rcsb pdb:5MU8|rcsb pdb:5TSW|rcsb pdb:5WUX|rcsb pdb:5YOY|rcsb pdb:6OOY|rcsb pdb:6OOZ|rcsb pdb:6OP0|rcsb pdb:6RMJ|rcsb pdb:6X81|rcsb pdb:6X82|rcsb pdb:6X83|rcsb pdb:6X85|rcsb pdb:6X86|rcsb pdb:7ASY|rcsb pdb:7AT7|rcsb pdb:7ATB|rcsb pdb:7JRA|rcsb pdb:7KP9|rcsb pdb:7KPA|rcsb pdb:7KPB|reactome:R-HSA-381340|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5626978|rcsb pdb:5UUI|reactome:R-HSA-5668541|reactome:R-HSA-6783783|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071230"(cellular response to amino acid stimulus)|refseq:NP_000585.2|dip:DIP-2895N	refseq:NP_042240.1|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039553"(suppression by virus of host chemokine activity)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR010806(Protein of unknown function DUF1406)|interpro:IPR011172(TNF-alpha receptor-II, vaccinia C22L type)|interpro:IPR034059|dip:DIP-61146N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/04	2017/08/10	rogid:27bbNim4bHFyBJscZC+/v9o96+g9606	rogid:BTcFeVFiucw38V1j0MR7Ui2hocA587200	rigid:1eiyoOV/PWixen88b7WYPYQYqds	false	-	sufficient binding region:1-192	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O57300	uniprotkb:P78556	intact:EBI-15577140	intact:EBI-3913209|uniprotkb:Q99664|uniprotkb:Q53S51|ensembl:ENSP00000351671	psi-mi:o57300_9poxv(display_long)|uniprotkb:crmD(gene name)|psi-mi:crmD(display_short)|uniprotkb:EVM003(gene name synonym)|uniprotkb:I1R(gene name synonym)|uniprotkb:EVH006(gene name synonym)|uniprotkb:EVH201(gene name synonym)	psi-mi:ccl20_human(display_long)|uniprotkb:CCL20(gene name)|psi-mi:CCL20(display_short)|uniprotkb:LARC(gene name synonym)|uniprotkb:MIP3A(gene name synonym)|uniprotkb:SCYA20(gene name synonym)|uniprotkb:Beta-chemokine exodus-1(gene name synonym)|uniprotkb:CC chemokine LARC(gene name synonym)|uniprotkb:Liver and activation-regulated chemokine(gene name synonym)|uniprotkb:Macrophage inflammatory protein 3 alpha(gene name synonym)|uniprotkb:Small-inducible cytokine A20(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Alejo et al. (2006)	pubmed:16581912|doi:10.1073/pnas.0510462103|imex:IM-23475	taxid:12643(ectromelia virus)|taxid:12643(Ectromelia virus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15577156|imex:IM-23475-2|dip:DIP-197597E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0030683"(mitigation of host immune response by virus)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR010806(Protein of unknown function DUF1406)|interpro:IPR011172(TNF-alpha receptor-II, vaccinia C22L type)|interpro:IPR034059|refseq:NP_671521.1|refseq:NP_671689.1|dip:DIP-61147N	refseq:NP_001123518.1|refseq:NP_004582.1|ensembl:ENSG00000115009(gene)|ensembl:ENST00000358813(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031731"(CCR6 chemokine receptor binding)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072678"(T cell migration)|go:"GO:0072679"(thymocyte migration)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR034133|interpro:IPR036048|interpro:IPR039809|mint:P78556|rcsb pdb:1M8A|rcsb pdb:2HCI|rcsb pdb:2JYO|rcsb pdb:5UR7|rcsb pdb:6WWZ|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|dip:DIP-5864N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/04	2017/08/10	rogid:nt7TSSOp8ijmgzBdUeSoiJmlDzw12643	rogid:ZOPQjamFqp/TxK/9rE4YVOUdKEE9606	rigid:yMfeMuTjROlL5fs4cdpxn45sbWo	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P16599	uniprotkb:P0DSV7	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	intact:EBI-15577099|uniprotkb:Q85407|uniprotkb:Q89098|uniprotkb:Q89118|uniprotkb:P34015	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:crmb_var67(display_long)|uniprotkb:CRMB(gene name)|psi-mi:CRMB(display_short)|uniprotkb:Viral tumor necrosis factor receptor II(gene name synonym)|uniprotkb:G2R(orf name)|uniprotkb:G4R(orf name)	psi-mi:"MI:0107"(surface plasmon resonance)	Alejo et al. (2006)	pubmed:16581912|doi:10.1073/pnas.0510462103|imex:IM-23475	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:587200(varv)|taxid:587200("Variola virus (isolate Human/India/Ind3/1967)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15577198|imex:IM-23475-4|dip:DIP-197576E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	refseq:NP_042240.1|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039553"(suppression by virus of host chemokine activity)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR010806(Protein of unknown function DUF1406)|interpro:IPR011172(TNF-alpha receptor-II, vaccinia C22L type)|interpro:IPR034059|dip:DIP-61146N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/04	2017/08/10	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	rogid:BTcFeVFiucw38V1j0MR7Ui2hocA587200	rigid:T9fQ01cDEb9J97UI5PXWX7NLOlo	false	-	sufficient binding region:1-192	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O35903	uniprotkb:Q8JLJ0	intact:EBI-7783383|ensembl:ENSMUSP00000024004|intact:MINT-106264|uniprotkb:Q9QYY6	intact:EBI-15577173	psi-mi:ccl25_mouse(display_long)|uniprotkb:Ccl25(gene name)|psi-mi:Ccl25(display_short)|uniprotkb:Scya25(gene name synonym)|uniprotkb:Teck(gene name synonym)|uniprotkb:Small-inducible cytokine A25(gene name synonym)|uniprotkb:Thymus-expressed chemokine(gene name synonym)|uniprotkb:Chemokine TECK(gene name synonym)	psi-mi:q8jlj0_9poxv(display_long)|uniprotkb:EVM008(gene name)|psi-mi:EVM008(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	Alejo et al. (2006)	pubmed:16581912|doi:10.1073/pnas.0510462103|imex:IM-23475	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:12643(ectromelia virus)|taxid:12643(Ectromelia virus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15577181|imex:IM-23475-3|dip:DIP-197585E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011240345.2|refseq:XP_011240346.2|ensembl:ENSMUSG00000023235(gene)|ensembl:ENSMUST00000024004(transcript)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031735"(CCR10 chemokine receptor binding)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050900"(leukocyte migration)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR034133|interpro:IPR036048|interpro:IPR039809|mint:O35903|reactome:R-MMU-380108|reactome:R-MMU-418594|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|refseq:NP_033164.1|dip:DIP-5885N	interpro:IPR010806(Protein of unknown function DUF1406)|refseq:NP_671526.1|dip:DIP-61151N	psi-mi:"MI:0465"(dip)	comment:mint|function:Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/04	2017/08/10	rogid:iFXjSeVsixwKlvqlDbax1vvLGCE10090	rogid:PsQn7hPKe8bG9SRs+7lWKVeHJoc12643	rigid:MRoyu4Pvud9EoT86iImeBuAbsJM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P40224	uniprotkb:Q8JLJ0	intact:EBI-15577217|ensembl:ENSMUSP00000108492|uniprotkb:Q4FJL5|uniprotkb:Q543V6	intact:EBI-15577173	psi-mi:sdf1_mouse(display_long)|uniprotkb:Cxcl12(gene name)|psi-mi:Cxcl12(display_short)|uniprotkb:Sdf1(gene name synonym)|uniprotkb:12-O-tetradecanoylphorbol 13-acetate repressed protein 1(gene name synonym)|uniprotkb:C-X-C motif chemokine 12(gene name synonym)|uniprotkb:Pre-B cell growth-stimulating factor(gene name synonym)|uniprotkb:Thymic lymphoma cell-stimulating factor(gene name synonym)	psi-mi:q8jlj0_9poxv(display_long)|uniprotkb:EVM008(gene name)|psi-mi:EVM008(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	Alejo et al. (2006)	pubmed:16581912|doi:10.1073/pnas.0510462103|imex:IM-23475	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:12643(ectromelia virus)|taxid:12643(Ectromelia virus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15577273|imex:IM-23475-5|dip:DIP-197587E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000061353(gene)|ensembl:ENSMUST00000112871(transcript)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001667"(ameboidal-type cell migration)|go:"GO:0001764"(neuron migration)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006952"(defense response)|go:"GO:0007281"(germ cell development)|go:"GO:0007411"(axon guidance)|go:"GO:0007420"(brain development)|go:"GO:0008009"(chemokine activity)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008354"(germ cell migration)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0033622"(integrin activation)|go:"GO:0038146"("chemokine (C-X-C motif) ligand 12 signaling pathway")|go:"GO:0042098"(T cell proliferation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR033899|interpro:IPR036048|interpro:IPR039813|reactome:R-MMU-376176|reactome:R-MMU-380108|reactome:R-MMU-418594|refseq:NP_038683.1|refseq:NP_068350.1|dip:DIP-61153N	interpro:IPR010806(Protein of unknown function DUF1406)|refseq:NP_671526.1|dip:DIP-61151N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/04	2017/08/10	rogid:tp7XTOFjPVKpUvXIIFJLWzusAxI10090	rogid:PsQn7hPKe8bG9SRs+7lWKVeHJoc12643	rigid:h80XcplMk398d4wK3inkaqhtGms	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O55038	uniprotkb:Q8JLJ0	intact:EBI-7783538|ensembl:ENSMUSP00000023840|intact:UNK-5364318	intact:EBI-15577173	psi-mi:cxl13_mouse(display_long)|uniprotkb:Cxcl13(gene name)|psi-mi:Cxcl13(display_short)|uniprotkb:Blc(gene name synonym)|uniprotkb:Scyb13(gene name synonym)|uniprotkb:Small-inducible cytokine B13(gene name synonym)|uniprotkb:B lymphocyte chemoattractant(gene name synonym)|uniprotkb:CXC chemokine BLC(gene name synonym)	psi-mi:q8jlj0_9poxv(display_long)|uniprotkb:EVM008(gene name)|psi-mi:EVM008(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	Alejo et al. (2006)	pubmed:16581912|doi:10.1073/pnas.0510462103|imex:IM-23475	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:12643(ectromelia virus)|taxid:12643(Ectromelia virus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15577290|imex:IM-23475-6|dip:DIP-197586E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000023078(gene)|ensembl:ENSMUST00000023840(transcript)|go:"GO:0002518"(lymphocyte chemotaxis across high endothelial venule)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031724"(CXCR5 chemokine receptor binding)|go:"GO:0031735"(CCR10 chemokine receptor binding)|go:"GO:0033625"(positive regulation of integrin activation)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0035754"(B cell chemotaxis)|go:"GO:0035768"(endothelial cell chemotaxis to fibroblast growth factor)|go:"GO:0035769"(B cell chemotaxis across high endothelial venule)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0048535"(lymph node development)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:2000545"(negative regulation of endothelial cell chemotaxis to fibroblast growth factor)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|mint:O55038|rcsb pdb:5IZB|rcsb pdb:5L7M|reactome:R-MMU-380108|reactome:R-MMU-418594|refseq:NP_061354.1|dip:DIP-57395N	interpro:IPR010806(Protein of unknown function DUF1406)|refseq:NP_671526.1|dip:DIP-61151N	psi-mi:"MI:0465"(dip)	comment:mint|function:Strongly chemotactic for B-lymphocytes, weakly for spleen monocytes and macrophages but no chemotactic activity for granulocytes. Binds to BLR1/CXCR5. May play a role in directing the migration of B-lymphocytes to follicles in secondary lymphoid organs	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/04	2017/08/10	rogid:t0RrvxBL8SPEUul/xdwDGEG/IDQ10090	rogid:PsQn7hPKe8bG9SRs+7lWKVeHJoc12643	rigid:93wc2K0wQnNbKcLp0GlW8CYl+pA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O95715	uniprotkb:P0DSV7	intact:EBI-2798068|uniprotkb:Q9BTR1|uniprotkb:Q86U69|uniprotkb:Q6UW97|uniprotkb:B3KQU8|uniprotkb:Q9NS21|ensembl:ENSP00000337065	intact:EBI-15577099|uniprotkb:Q85407|uniprotkb:Q89098|uniprotkb:Q89118|uniprotkb:P34015	psi-mi:cxl14_human(display_long)|uniprotkb:MIP2G(gene name synonym)|uniprotkb:NJAC(gene name synonym)|uniprotkb:SCYB14(gene name synonym)|uniprotkb:Chemokine BRAK(gene name synonym)|uniprotkb:MIP-2G(gene name synonym)|uniprotkb:Small-inducible cytokine B14(gene name synonym)|uniprotkb:UNQ240/PRO273(orf name)|uniprotkb:PSEC0212(orf name)|uniprotkb:CXCL14(gene name)|psi-mi:CXCL14(display_short)	psi-mi:crmb_var67(display_long)|uniprotkb:CRMB(gene name)|psi-mi:CRMB(display_short)|uniprotkb:Viral tumor necrosis factor receptor II(gene name synonym)|uniprotkb:G2R(orf name)|uniprotkb:G4R(orf name)	psi-mi:"MI:0107"(surface plasmon resonance)	Alejo et al. (2006)	pubmed:16581912|doi:10.1073/pnas.0510462103|imex:IM-23475	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:587200(varv)|taxid:587200("Variola virus (isolate Human/India/Ind3/1967)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15577307|imex:IM-23475-7|dip:DIP-197596E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-61148N|refseq:NP_004878.2|ensembl:ENSG00000145824(gene)|ensembl:ENST00000337225(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006935"(chemotaxis)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0031640"(killing of cells of another organism)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039088|mint:O95715|rcsb pdb:2HDL|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)	refseq:NP_042240.1|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039553"(suppression by virus of host chemokine activity)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR010806(Protein of unknown function DUF1406)|interpro:IPR011172(TNF-alpha receptor-II, vaccinia C22L type)|interpro:IPR034059|dip:DIP-61146N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/04	2017/08/10	rogid:VzzrayuCD0FYBEMcVpZY2RtWCc49606	rogid:BTcFeVFiucw38V1j0MR7Ui2hocA587200	rigid:YOG+PmkTT8O0TMai2gyiZUJgS+c	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06804	uniprotkb:P0DSV7	intact:EBI-1563469|uniprotkb:O35853|uniprotkb:Q62326|uniprotkb:Q91VF3|ensembl:ENSMUSP00000025263	intact:EBI-15577099|uniprotkb:Q85407|uniprotkb:Q89098|uniprotkb:Q89118|uniprotkb:P34015	psi-mi:tnfa_mouse(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:crmb_var67(display_long)|uniprotkb:CRMB(gene name)|psi-mi:CRMB(display_short)|uniprotkb:Viral tumor necrosis factor receptor II(gene name synonym)|uniprotkb:G2R(orf name)|uniprotkb:G4R(orf name)	psi-mi:"MI:0107"(surface plasmon resonance)	Alejo et al. (2006)	pubmed:16581912|doi:10.1073/pnas.0510462103|imex:IM-23475	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:587200(varv)|taxid:587200("Variola virus (isolate Human/India/Ind3/1967)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15577324|imex:IM-23475-8|dip:DIP-197577E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_038721.1|refseq:NP_001265530.1|dip:DIP-40029N|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|rcsb pdb:2TNF|rcsb pdb:7KP7|rcsb pdb:7KP8|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5626978|reactome:R-MMU-5668541|reactome:R-MMU-75893|ensembl:ENSMUSG00000024401(gene)|ensembl:ENSMUST00000025263(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002269"(leukocyte activation involved in inflammatory response)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009615"(response to virus)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030141"(secretory granule)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)	refseq:NP_042240.1|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039553"(suppression by virus of host chemokine activity)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR010806(Protein of unknown function DUF1406)|interpro:IPR011172(TNF-alpha receptor-II, vaccinia C22L type)|interpro:IPR034059|dip:DIP-61146N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/04	2017/08/10	rogid:U10yo9K5M4wAaunUKhCKkd3G3As10090	rogid:BTcFeVFiucw38V1j0MR7Ui2hocA587200	rigid:oRVZaPTBkK6MiMSDQVqV9mfF944	false	-	sufficient binding region:1-192	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NRJ3	uniprotkb:O57300	intact:EBI-7783254|ensembl:ENSP00000354416|ensembl:ENSP00000426424|intact:MINT-8163536|intact:MINT-6629016|uniprotkb:D7RIE7	intact:EBI-15577140	psi-mi:ccl28_human(display_long)|uniprotkb:Mucosae-associated epithelial chemokine(gene name synonym)|uniprotkb:CCL28(gene name)|psi-mi:CCL28(display_short)|uniprotkb:SCYA28(gene name synonym)|uniprotkb:Small-inducible cytokine A28(gene name synonym)|uniprotkb:Protein CCK1(gene name synonym)	psi-mi:o57300_9poxv(display_long)|uniprotkb:crmD(gene name)|psi-mi:crmD(display_short)|uniprotkb:EVM003(gene name synonym)|uniprotkb:I1R(gene name synonym)|uniprotkb:EVH006(gene name synonym)|uniprotkb:EVH201(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Alejo et al. (2006)	pubmed:16581912|doi:10.1073/pnas.0510462103|imex:IM-23475	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:12643(ectromelia virus)|taxid:12643(Ectromelia virus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15577405|imex:IM-23475-12|dip:DIP-197598E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001288802.1|refseq:NP_001288803.1|ensembl:ENSG00000151882(gene)|ensembl:ENST00000361115(transcript)|ensembl:ENST00000489442(transcript)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006955"(immune response)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008009"(chemokine activity)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0051715"(cytolysis in another organism)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|mint:Q9NRJ3|rcsb pdb:6CWS|reactome:R-HSA-380108|reactome:R-HSA-418594|refseq:NP_683513.1|dip:DIP-57392N	go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0030683"(mitigation of host immune response by virus)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR010806(Protein of unknown function DUF1406)|interpro:IPR011172(TNF-alpha receptor-II, vaccinia C22L type)|interpro:IPR034059|refseq:NP_671521.1|refseq:NP_671689.1|dip:DIP-61147N	psi-mi:"MI:0465"(dip)	function:Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner|comment:mint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/04	2017/08/10	rogid:s++M3xMbRLf+mNYq68dD7mfdRxE9606	rogid:nt7TSSOp8ijmgzBdUeSoiJmlDzw12643	rigid:kh+Oa1VKchw5bhNSxYFbNggi0ms	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01374	uniprotkb:P0DSV7	intact:EBI-524105|uniprotkb:Q8N4C3|uniprotkb:Q9UKS8|ensembl:ENSP00000395976|ensembl:ENSP00000402413|ensembl:ENSP00000403495|ensembl:ENSP00000412555|ensembl:ENSP00000413450|ensembl:ENSP00000416509	intact:EBI-15577099|uniprotkb:Q85407|uniprotkb:Q89098|uniprotkb:Q89118|uniprotkb:P34015	psi-mi:tnfb_human(display_long)|uniprotkb:TNF-beta(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 1(gene name synonym)|uniprotkb:LTA(gene name)|psi-mi:LTA(display_short)|uniprotkb:TNFB(gene name synonym)|uniprotkb:TNFSF1(gene name synonym)	psi-mi:crmb_var67(display_long)|uniprotkb:CRMB(gene name)|psi-mi:CRMB(display_short)|uniprotkb:Viral tumor necrosis factor receptor II(gene name synonym)|uniprotkb:G2R(orf name)|uniprotkb:G4R(orf name)	psi-mi:"MI:0107"(surface plasmon resonance)	Alejo et al. (2006)	pubmed:16581912|doi:10.1073/pnas.0510462103|imex:IM-23475	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:587200(varv)|taxid:587200("Variola virus (isolate Human/India/Ind3/1967)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15577386|imex:IM-23475-11|dip:DIP-197578E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000226979(gene)|ensembl:ENSG00000230279(gene)|ensembl:ENSG00000231408(gene)|ensembl:ENST00000412851(transcript)|ensembl:ENST00000418386(transcript)|ensembl:ENST00000426845(transcript)|ensembl:ENST00000436519(transcript)|ensembl:ENST00000454783(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|ensembl:ENST00000454550(transcript)|go:"GO:0007584"(response to nutrient)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0042493"|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048535"(lymph node development)|go:"GO:0050830"(defense response to Gram-positive bacterium)|interpro:IPR002960(Tumour necrosis factor beta/lymphotoxin alpha)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|rcsb pdb:1TNR|rcsb pdb:4MXV|go:"GO:0060252"(positive regulation of glial cell proliferation)|rcsb pdb:4MXW|reactome:R-HSA-5668541|reactome:R-HSA-5669034|reactome:R-HSA-5676594|refseq:XP_011512919.1|refseq:XP_011512920.1|refseq:XP_011512917.1|refseq:XP_011512918.1|refseq:NP_000586.2|refseq:NP_001153212.1|dip:DIP-2910N	refseq:NP_042240.1|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039553"(suppression by virus of host chemokine activity)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR010806(Protein of unknown function DUF1406)|interpro:IPR011172(TNF-alpha receptor-II, vaccinia C22L type)|interpro:IPR034059|dip:DIP-61146N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/04	2017/08/10	rogid:DRe0vNUyg7gLQTNqptel3XPDY3w9606	rogid:BTcFeVFiucw38V1j0MR7Ui2hocA587200	rigid:3EzaOU1520LcPuxfPtAKpuj/Y+A	false	-	sufficient binding region:1-192	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P48061	uniprotkb:O57300	intact:EBI-3913254|uniprotkb:H7BYN8|uniprotkb:B2R4G0|uniprotkb:Q9H554|uniprotkb:E7EVL0|uniprotkb:Q5IT36|uniprotkb:Q2L985|uniprotkb:Q2L986|uniprotkb:Q2L988|uniprotkb:Q6ICW0|ensembl:ENSP00000363551	intact:EBI-15577140	psi-mi:sdf1_human(display_long)|uniprotkb:CXCL12(gene name)|psi-mi:CXCL12(display_short)|uniprotkb:SDF1(gene name synonym)|uniprotkb:SDF1A(gene name synonym)|uniprotkb:SDF1B(gene name synonym)|uniprotkb:C-X-C motif chemokine 12(gene name synonym)|uniprotkb:Intercrine reduced in hepatomas(gene name synonym)|uniprotkb:Pre-B cell growth-stimulating factor(gene name synonym)	psi-mi:o57300_9poxv(display_long)|uniprotkb:crmD(gene name)|psi-mi:crmD(display_short)|uniprotkb:EVM003(gene name synonym)|uniprotkb:I1R(gene name synonym)|uniprotkb:EVH006(gene name synonym)|uniprotkb:EVH201(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Alejo et al. (2006)	pubmed:16581912|doi:10.1073/pnas.0510462103|imex:IM-23475	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:12643(ectromelia virus)|taxid:12643(Ectromelia virus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15577369|imex:IM-23475-10|dip:DIP-197600E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000600.1|refseq:NP_001029058.1|refseq:NP_954637.1|refseq:NP_001171605.1|refseq:NP_001264919.1|ensembl:ENSG00000107562(gene)|ensembl:ENST00000374429(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001764"(neuron migration)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008083"(growth factor activity)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009314"(response to radiation)|go:"GO:0009408"(response to heat)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0033622"(integrin activation)|go:"GO:0038146"("chemokine (C-X-C motif) ligand 12 signaling pathway")|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0005576"(extracellular region)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|go:"GO:1990478"(response to ultrasound)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR033899|interpro:IPR036048|interpro:IPR039813|rcsb pdb:1A15|rcsb pdb:1QG7|rcsb pdb:1SDF|rcsb pdb:1VMC|rcsb pdb:2K01|rcsb pdb:2K03|rcsb pdb:2K04|rcsb pdb:2K05|rcsb pdb:2KEC|rcsb pdb:2J7Z|rcsb pdb:2KED|rcsb pdb:2KEE|rcsb pdb:2KOL|rcsb pdb:2N55|rcsb pdb:2NWG|rcsb pdb:2SDF|rcsb pdb:3GV3|rcsb pdb:3HP3|rcsb pdb:4LMQ|rcsb pdb:4UAI|rcsb pdb:6SHR|reactome:R-HSA-1251985|reactome:R-HSA-376176|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-9018519|dip:DIP-391N	go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0030683"(mitigation of host immune response by virus)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR010806(Protein of unknown function DUF1406)|interpro:IPR011172(TNF-alpha receptor-II, vaccinia C22L type)|interpro:IPR034059|refseq:NP_671521.1|refseq:NP_671689.1|dip:DIP-61147N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/04	2017/08/10	rogid:DHGsB0zBMh/qkZCgG/n4mAVkfto9606	rogid:nt7TSSOp8ijmgzBdUeSoiJmlDzw12643	rigid:IYRSJ1giRHb3ibFnTD5lHmNyP28	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O35903	uniprotkb:Q9JFT2	intact:EBI-7783383|ensembl:ENSMUSP00000024004|intact:MINT-106264|uniprotkb:Q9QYY6	intact:EBI-15577343	psi-mi:ccl25_mouse(display_long)|uniprotkb:Ccl25(gene name)|psi-mi:Ccl25(display_short)|uniprotkb:Scya25(gene name synonym)|uniprotkb:Teck(gene name synonym)|uniprotkb:Small-inducible cytokine A25(gene name synonym)|uniprotkb:Thymus-expressed chemokine(gene name synonym)|uniprotkb:Chemokine TECK(gene name synonym)	psi-mi:q9jft2_9poxv(display_long)|uniprotkb:C3R(gene name)|psi-mi:C3R(display_short)|uniprotkb:EVH184(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Alejo et al. (2006)	pubmed:16581912|doi:10.1073/pnas.0510462103|imex:IM-23475	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:12643(ectromelia virus)|taxid:12643(Ectromelia virus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15577352|imex:IM-23475-9|dip:DIP-197588E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011240345.2|refseq:XP_011240346.2|ensembl:ENSMUSG00000023235(gene)|ensembl:ENSMUST00000024004(transcript)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031735"(CCR10 chemokine receptor binding)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050900"(leukocyte migration)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR034133|interpro:IPR036048|interpro:IPR039809|mint:O35903|reactome:R-MMU-380108|reactome:R-MMU-418594|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|refseq:NP_033164.1|dip:DIP-5885N	interpro:IPR009176(Uncharacterised conserved protein VAC-C8L)|interpro:IPR010806(Protein of unknown function DUF1406)|refseq:NP_671676.1|dip:DIP-61152N	psi-mi:"MI:0465"(dip)	comment:mint|function:Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/04	2017/08/10	rogid:iFXjSeVsixwKlvqlDbax1vvLGCE10090	rogid:yr2V8Mg7tMuglF0k4Ppw3bpkUxI12643	rigid:4ELnqGBcT/aeFtKdmv22cCL10Y4	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O15444	uniprotkb:P0DSV7	intact:EBI-7783341|ensembl:ENSP00000324756|ensembl:ENSP00000375086|ensembl:ENSP00000504875|ensembl:ENSP00000505422|uniprotkb:A1L4J4|uniprotkb:B5MCA5|uniprotkb:A8K9E7|intact:MINT-106224|uniprotkb:A6NI52|uniprotkb:Q96KJ7	intact:EBI-15577099|uniprotkb:Q85407|uniprotkb:Q89098|uniprotkb:Q89118|uniprotkb:P34015	psi-mi:ccl25_human(display_long)|uniprotkb:CCL25(gene name)|psi-mi:CCL25(display_short)|uniprotkb:SCYA25(gene name synonym)|uniprotkb:TECK(gene name synonym)|uniprotkb:Small-inducible cytokine A25(gene name synonym)|uniprotkb:Thymus-expressed chemokine(gene name synonym)|uniprotkb:Chemokine TECK(gene name synonym)	psi-mi:crmb_var67(display_long)|uniprotkb:CRMB(gene name)|psi-mi:CRMB(display_short)|uniprotkb:Viral tumor necrosis factor receptor II(gene name synonym)|uniprotkb:G2R(orf name)|uniprotkb:G4R(orf name)	psi-mi:"MI:0107"(surface plasmon resonance)	Alejo et al. (2006)	pubmed:16581912|doi:10.1073/pnas.0510462103|imex:IM-23475	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:587200(varv)|taxid:587200("Variola virus (isolate Human/India/Ind3/1967)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15577422|imex:IM-23475-13|dip:DIP-197579E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR034133|interpro:IPR036048|interpro:IPR039809|mint:O15444|reactome:R-HSA-380108|reactome:R-HSA-418594|refseq:XP_011526479.1|refseq:XP_016882609.1|refseq:XP_016882610.1|refseq:XP_016882611.1|ensembl:ENSG00000131142(gene)|ensembl:ENST00000315626(transcript)|ensembl:ENST00000390669(transcript)|ensembl:ENST00000680506(transcript)|ensembl:ENST00000680646(transcript)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031735"(CCR10 chemokine receptor binding)|refseq:NP_005615.2|refseq:NP_001188288.1|dip:DIP-5883N	refseq:NP_042240.1|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039553"(suppression by virus of host chemokine activity)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR010806(Protein of unknown function DUF1406)|interpro:IPR011172(TNF-alpha receptor-II, vaccinia C22L type)|interpro:IPR034059|dip:DIP-61146N	psi-mi:"MI:0465"(dip)	comment:mint|function:Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Isoform 2 is an antagonist of isoform 1	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/04	2017/08/10	rogid:NRbEGkpQKoD/tUBdbJ+JJ4rL0pA9606	rogid:BTcFeVFiucw38V1j0MR7Ui2hocA587200	rigid:NF+I/4ZLt3tEW78BZXx9EbdlW38	false	-	sufficient binding region:194-348	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O35903	uniprotkb:O57300	intact:EBI-7783383|ensembl:ENSMUSP00000024004|intact:MINT-106264|uniprotkb:Q9QYY6	intact:EBI-15577140	psi-mi:ccl25_mouse(display_long)|uniprotkb:Ccl25(gene name)|psi-mi:Ccl25(display_short)|uniprotkb:Scya25(gene name synonym)|uniprotkb:Teck(gene name synonym)|uniprotkb:Small-inducible cytokine A25(gene name synonym)|uniprotkb:Thymus-expressed chemokine(gene name synonym)|uniprotkb:Chemokine TECK(gene name synonym)	psi-mi:o57300_9poxv(display_long)|uniprotkb:crmD(gene name)|psi-mi:crmD(display_short)|uniprotkb:EVM003(gene name synonym)|uniprotkb:I1R(gene name synonym)|uniprotkb:EVH006(gene name synonym)|uniprotkb:EVH201(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Alejo et al. (2006)	pubmed:16581912|doi:10.1073/pnas.0510462103|imex:IM-23475	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:12643(ectromelia virus)|taxid:12643(Ectromelia virus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15577441|imex:IM-23475-14|dip:DIP-197599E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011240345.2|refseq:XP_011240346.2|ensembl:ENSMUSG00000023235(gene)|ensembl:ENSMUST00000024004(transcript)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031735"(CCR10 chemokine receptor binding)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050900"(leukocyte migration)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR034133|interpro:IPR036048|interpro:IPR039809|mint:O35903|reactome:R-MMU-380108|reactome:R-MMU-418594|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|refseq:NP_033164.1|dip:DIP-5885N	go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0030683"(mitigation of host immune response by virus)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR010806(Protein of unknown function DUF1406)|interpro:IPR011172(TNF-alpha receptor-II, vaccinia C22L type)|interpro:IPR034059|refseq:NP_671521.1|refseq:NP_671689.1|dip:DIP-61147N	psi-mi:"MI:0465"(dip)	comment:mint|function:Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/04	2017/08/10	rogid:iFXjSeVsixwKlvqlDbax1vvLGCE10090	rogid:nt7TSSOp8ijmgzBdUeSoiJmlDzw12643	rigid:CjsuisQuVdF29/pUQTnNfuvOaVI	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O55038	uniprotkb:Q9JFT2	intact:EBI-7783538|ensembl:ENSMUSP00000023840|intact:UNK-5364318	intact:EBI-15577343	psi-mi:cxl13_mouse(display_long)|uniprotkb:Cxcl13(gene name)|psi-mi:Cxcl13(display_short)|uniprotkb:Blc(gene name synonym)|uniprotkb:Scyb13(gene name synonym)|uniprotkb:Small-inducible cytokine B13(gene name synonym)|uniprotkb:B lymphocyte chemoattractant(gene name synonym)|uniprotkb:CXC chemokine BLC(gene name synonym)	psi-mi:q9jft2_9poxv(display_long)|uniprotkb:C3R(gene name)|psi-mi:C3R(display_short)|uniprotkb:EVH184(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Alejo et al. (2006)	pubmed:16581912|doi:10.1073/pnas.0510462103|imex:IM-23475	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:12643(ectromelia virus)|taxid:12643(Ectromelia virus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15577458|imex:IM-23475-15|dip:DIP-197589E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000023078(gene)|ensembl:ENSMUST00000023840(transcript)|go:"GO:0002518"(lymphocyte chemotaxis across high endothelial venule)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031724"(CXCR5 chemokine receptor binding)|go:"GO:0031735"(CCR10 chemokine receptor binding)|go:"GO:0033625"(positive regulation of integrin activation)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0035754"(B cell chemotaxis)|go:"GO:0035768"(endothelial cell chemotaxis to fibroblast growth factor)|go:"GO:0035769"(B cell chemotaxis across high endothelial venule)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0048535"(lymph node development)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:2000545"(negative regulation of endothelial cell chemotaxis to fibroblast growth factor)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|mint:O55038|rcsb pdb:5IZB|rcsb pdb:5L7M|reactome:R-MMU-380108|reactome:R-MMU-418594|refseq:NP_061354.1|dip:DIP-57395N	interpro:IPR009176(Uncharacterised conserved protein VAC-C8L)|interpro:IPR010806(Protein of unknown function DUF1406)|refseq:NP_671676.1|dip:DIP-61152N	psi-mi:"MI:0465"(dip)	comment:mint|function:Strongly chemotactic for B-lymphocytes, weakly for spleen monocytes and macrophages but no chemotactic activity for granulocytes. Binds to BLR1/CXCR5. May play a role in directing the migration of B-lymphocytes to follicles in secondary lymphoid organs	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/04	2017/08/10	rogid:t0RrvxBL8SPEUul/xdwDGEG/IDQ10090	rogid:yr2V8Mg7tMuglF0k4Ppw3bpkUxI12643	rigid:6a27usWpyf83bPGRPOyvRvCy9B4	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NRJ3	uniprotkb:P0DSV7	intact:EBI-7783254|ensembl:ENSP00000354416|ensembl:ENSP00000426424|intact:MINT-8163536|intact:MINT-6629016|uniprotkb:D7RIE7	intact:EBI-15577099|uniprotkb:Q85407|uniprotkb:Q89098|uniprotkb:Q89118|uniprotkb:P34015	psi-mi:ccl28_human(display_long)|uniprotkb:Mucosae-associated epithelial chemokine(gene name synonym)|uniprotkb:CCL28(gene name)|psi-mi:CCL28(display_short)|uniprotkb:SCYA28(gene name synonym)|uniprotkb:Small-inducible cytokine A28(gene name synonym)|uniprotkb:Protein CCK1(gene name synonym)	psi-mi:crmb_var67(display_long)|uniprotkb:CRMB(gene name)|psi-mi:CRMB(display_short)|uniprotkb:Viral tumor necrosis factor receptor II(gene name synonym)|uniprotkb:G2R(orf name)|uniprotkb:G4R(orf name)	psi-mi:"MI:0107"(surface plasmon resonance)	Alejo et al. (2006)	pubmed:16581912|doi:10.1073/pnas.0510462103|imex:IM-23475	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:587200(varv)|taxid:587200("Variola virus (isolate Human/India/Ind3/1967)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15577475|imex:IM-23475-16|dip:DIP-197591E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001288802.1|refseq:NP_001288803.1|ensembl:ENSG00000151882(gene)|ensembl:ENST00000361115(transcript)|ensembl:ENST00000489442(transcript)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006955"(immune response)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008009"(chemokine activity)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0051715"(cytolysis in another organism)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|mint:Q9NRJ3|rcsb pdb:6CWS|reactome:R-HSA-380108|reactome:R-HSA-418594|refseq:NP_683513.1|dip:DIP-57392N	refseq:NP_042240.1|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039553"(suppression by virus of host chemokine activity)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR010806(Protein of unknown function DUF1406)|interpro:IPR011172(TNF-alpha receptor-II, vaccinia C22L type)|interpro:IPR034059|dip:DIP-61146N	psi-mi:"MI:0465"(dip)	function:Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner|comment:mint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/04	2017/08/10	rogid:s++M3xMbRLf+mNYq68dD7mfdRxE9606	rogid:BTcFeVFiucw38V1j0MR7Ui2hocA587200	rigid:UATQBYggqKm0MObT1q2fKampCWo	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O95715	uniprotkb:O57300	intact:EBI-2798068|uniprotkb:Q9BTR1|uniprotkb:Q86U69|uniprotkb:Q6UW97|uniprotkb:B3KQU8|uniprotkb:Q9NS21|ensembl:ENSP00000337065	intact:EBI-15577140	psi-mi:cxl14_human(display_long)|uniprotkb:MIP2G(gene name synonym)|uniprotkb:NJAC(gene name synonym)|uniprotkb:SCYB14(gene name synonym)|uniprotkb:Chemokine BRAK(gene name synonym)|uniprotkb:MIP-2G(gene name synonym)|uniprotkb:Small-inducible cytokine B14(gene name synonym)|uniprotkb:UNQ240/PRO273(orf name)|uniprotkb:PSEC0212(orf name)|uniprotkb:CXCL14(gene name)|psi-mi:CXCL14(display_short)	psi-mi:o57300_9poxv(display_long)|uniprotkb:crmD(gene name)|psi-mi:crmD(display_short)|uniprotkb:EVM003(gene name synonym)|uniprotkb:I1R(gene name synonym)|uniprotkb:EVH006(gene name synonym)|uniprotkb:EVH201(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Alejo et al. (2006)	pubmed:16581912|doi:10.1073/pnas.0510462103|imex:IM-23475	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:12643(ectromelia virus)|taxid:12643(Ectromelia virus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15577492|imex:IM-23475-17|dip:DIP-197602E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-61148N|refseq:NP_004878.2|ensembl:ENSG00000145824(gene)|ensembl:ENST00000337225(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006935"(chemotaxis)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0031640"(killing of cells of another organism)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039088|mint:O95715|rcsb pdb:2HDL|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)	go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0030683"(mitigation of host immune response by virus)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR010806(Protein of unknown function DUF1406)|interpro:IPR011172(TNF-alpha receptor-II, vaccinia C22L type)|interpro:IPR034059|refseq:NP_671521.1|refseq:NP_671689.1|dip:DIP-61147N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/04	2017/08/10	rogid:VzzrayuCD0FYBEMcVpZY2RtWCc49606	rogid:nt7TSSOp8ijmgzBdUeSoiJmlDzw12643	rigid:UXGN2C4/G/FA/MyBSFPiCx1zP0o	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O15444	uniprotkb:Q9YP87	intact:EBI-7783341|ensembl:ENSP00000324756|ensembl:ENSP00000375086|ensembl:ENSP00000504875|ensembl:ENSP00000505422|uniprotkb:A1L4J4|uniprotkb:B5MCA5|uniprotkb:A8K9E7|intact:MINT-106224|uniprotkb:A6NI52|uniprotkb:Q96KJ7	intact:EBI-15577511	psi-mi:ccl25_human(display_long)|uniprotkb:CCL25(gene name)|psi-mi:CCL25(display_short)|uniprotkb:SCYA25(gene name synonym)|uniprotkb:TECK(gene name synonym)|uniprotkb:Small-inducible cytokine A25(gene name synonym)|uniprotkb:Thymus-expressed chemokine(gene name synonym)|uniprotkb:Chemokine TECK(gene name synonym)	psi-mi:q9yp87_cowpx(display_long)|uniprotkb:CPXV191(orf name)|uniprotkb:crmC(gene name)|psi-mi:crmC(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	Alejo et al. (2006)	pubmed:16581912|doi:10.1073/pnas.0510462103|imex:IM-23475	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10243(cowpx)|taxid:10243(Cowpox virus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15577520|imex:IM-23475-18|dip:DIP-197580E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR034133|interpro:IPR036048|interpro:IPR039809|mint:O15444|reactome:R-HSA-380108|reactome:R-HSA-418594|refseq:XP_011526479.1|refseq:XP_016882609.1|refseq:XP_016882610.1|refseq:XP_016882611.1|ensembl:ENSG00000131142(gene)|ensembl:ENST00000315626(transcript)|ensembl:ENST00000390669(transcript)|ensembl:ENST00000680506(transcript)|ensembl:ENST00000680646(transcript)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031735"(CCR10 chemokine receptor binding)|refseq:NP_005615.2|refseq:NP_001188288.1|dip:DIP-5883N	interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|refseq:NP_619973.1|dip:DIP-61149N	psi-mi:"MI:0465"(dip)	comment:mint|function:Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Isoform 2 is an antagonist of isoform 1	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/04	2017/08/10	rogid:NRbEGkpQKoD/tUBdbJ+JJ4rL0pA9606	rogid:QvBFqjDDTbSuMSOr2qx28gwXZRc10243	rigid:vfnwsLRSVdc9oJ53Dln7bPIJ8Pg	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P40224	uniprotkb:Q9JFT2	intact:EBI-15577217|ensembl:ENSMUSP00000108492|uniprotkb:Q4FJL5|uniprotkb:Q543V6	intact:EBI-15577343	psi-mi:sdf1_mouse(display_long)|uniprotkb:Cxcl12(gene name)|psi-mi:Cxcl12(display_short)|uniprotkb:Sdf1(gene name synonym)|uniprotkb:12-O-tetradecanoylphorbol 13-acetate repressed protein 1(gene name synonym)|uniprotkb:C-X-C motif chemokine 12(gene name synonym)|uniprotkb:Pre-B cell growth-stimulating factor(gene name synonym)|uniprotkb:Thymic lymphoma cell-stimulating factor(gene name synonym)	psi-mi:q9jft2_9poxv(display_long)|uniprotkb:C3R(gene name)|psi-mi:C3R(display_short)|uniprotkb:EVH184(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Alejo et al. (2006)	pubmed:16581912|doi:10.1073/pnas.0510462103|imex:IM-23475	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:12643(ectromelia virus)|taxid:12643(Ectromelia virus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15577537|imex:IM-23475-19|dip:DIP-197590E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000061353(gene)|ensembl:ENSMUST00000112871(transcript)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001667"(ameboidal-type cell migration)|go:"GO:0001764"(neuron migration)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006952"(defense response)|go:"GO:0007281"(germ cell development)|go:"GO:0007411"(axon guidance)|go:"GO:0007420"(brain development)|go:"GO:0008009"(chemokine activity)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008354"(germ cell migration)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0033622"(integrin activation)|go:"GO:0038146"("chemokine (C-X-C motif) ligand 12 signaling pathway")|go:"GO:0042098"(T cell proliferation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR033899|interpro:IPR036048|interpro:IPR039813|reactome:R-MMU-376176|reactome:R-MMU-380108|reactome:R-MMU-418594|refseq:NP_038683.1|refseq:NP_068350.1|dip:DIP-61153N	interpro:IPR009176(Uncharacterised conserved protein VAC-C8L)|interpro:IPR010806(Protein of unknown function DUF1406)|refseq:NP_671676.1|dip:DIP-61152N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/04	2017/08/10	rogid:tp7XTOFjPVKpUvXIIFJLWzusAxI10090	rogid:yr2V8Mg7tMuglF0k4Ppw3bpkUxI12643	rigid:SFv88KefyApXQl1IFah2+O5XGMs	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O43927	uniprotkb:O57300	intact:EBI-719170|ensembl:ENSP00000507688|ensembl:ENSP00000286758	intact:EBI-15577140	psi-mi:cxl13_human(display_long)|uniprotkb:Small-inducible cytokine B13(gene name synonym)|uniprotkb:B lymphocyte chemoattractant(gene name synonym)|uniprotkb:CXC chemokine BLC(gene name synonym)|uniprotkb:B cell-attracting chemokine 1(gene name synonym)|uniprotkb:CXCL13(gene name)|psi-mi:CXCL13(display_short)|uniprotkb:BCA1(gene name synonym)|uniprotkb:BLC(gene name synonym)|uniprotkb:SCYB13(gene name synonym)|uniprotkb:Angie(gene name synonym)	psi-mi:o57300_9poxv(display_long)|uniprotkb:crmD(gene name)|psi-mi:crmD(display_short)|uniprotkb:EVM003(gene name synonym)|uniprotkb:I1R(gene name synonym)|uniprotkb:EVH006(gene name synonym)|uniprotkb:EVH201(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Alejo et al. (2006)	pubmed:16581912|doi:10.1073/pnas.0510462103|imex:IM-23475	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:12643(ectromelia virus)|taxid:12643(Ectromelia virus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15577571|imex:IM-23475-21|dip:DIP-197601E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006410.1|go:"GO:0008201"(heparin binding)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031724"(CXCR5 chemokine receptor binding)|go:"GO:0031735"(CCR10 chemokine receptor binding)|go:"GO:0033625"(positive regulation of integrin activation)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0035754"(B cell chemotaxis)|go:"GO:0035768"(endothelial cell chemotaxis to fibroblast growth factor)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:2000545"(negative regulation of endothelial cell chemotaxis to fibroblast growth factor)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|rcsb pdb:5CBA|rcsb pdb:5CBE|rcsb pdb:6VGJ|rcsb pdb:7JNY|reactome:R-HSA-380108|reactome:R-HSA-418594|ensembl:ENST00000286758(transcript)|ensembl:ENST00000682537(transcript)|go:"GO:0002467"(germinal center formation)|go:"GO:0002518"(lymphocyte chemotaxis across high endothelial venule)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0002920"(regulation of humoral immune response)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|refseq:XP_006714126.1|ensembl:ENSG00000156234(gene)|dip:DIP-5914N	go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0030683"(mitigation of host immune response by virus)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR010806(Protein of unknown function DUF1406)|interpro:IPR011172(TNF-alpha receptor-II, vaccinia C22L type)|interpro:IPR034059|refseq:NP_671521.1|refseq:NP_671689.1|dip:DIP-61147N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/04	2017/08/10	rogid:5/65nY3r+t/6Br3fQLOX+1JENJQ9606	rogid:nt7TSSOp8ijmgzBdUeSoiJmlDzw12643	rigid:nuGnwfbT23M8jzxn54iu2QAps8c	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01375	uniprotkb:Q9YP87	intact:EBI-359977|uniprotkb:O43647|uniprotkb:Q9P1Q2|uniprotkb:Q9UIV3|ensembl:ENSP00000365290|ensembl:ENSP00000372988|ensembl:ENSP00000389490|ensembl:ENSP00000389492|ensembl:ENSP00000392858|ensembl:ENSP00000398698|ensembl:ENSP00000410668	intact:EBI-15577511	psi-mi:tnfa_human(display_long)|uniprotkb:TNF(gene name)|psi-mi:TNF(display_short)|uniprotkb:TNFA(gene name synonym)|uniprotkb:TNFSF2(gene name synonym)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)	psi-mi:q9yp87_cowpx(display_long)|uniprotkb:CPXV191(orf name)|uniprotkb:crmC(gene name)|psi-mi:crmC(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	Alejo et al. (2006)	pubmed:16581912|doi:10.1073/pnas.0510462103|imex:IM-23475	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10243(cowpx)|taxid:10243(Cowpox virus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15577554|imex:IM-23475-20|dip:DIP-197581E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204490(gene)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050890"(cognition)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0002020"(protease binding)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007254"(JNK cascade)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009615"(response to virus)|go:"GO:0009651"(response to salt stress)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|ensembl:ENSG00000206439(gene)|ensembl:ENSG00000223952(gene)|ensembl:ENSG00000228321(gene)|ensembl:ENSG00000228849(gene)|ensembl:ENSG00000230108(gene)|ensembl:ENSG00000232810(gene)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|ensembl:ENST00000376122(transcript)|ensembl:ENST00000383496(transcript)|ensembl:ENST00000412275(transcript)|ensembl:ENST00000420425(transcript)|ensembl:ENST00000443707(transcript)|ensembl:ENST00000448781(transcript)|ensembl:ENST00000449264(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045598"(regulation of fat cell differentiation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|reactome:R-HSA-75893|reactome:R-HSA-6785807|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071677"(positive regulation of mononuclear cell migration)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|mint:P01375|rcsb pdb:1A8M|rcsb pdb:1TNF|rcsb pdb:2AZ5|rcsb pdb:2E7A|rcsb pdb:2TUN|rcsb pdb:2ZJC|rcsb pdb:2ZPX|rcsb pdb:3ALQ|rcsb pdb:3IT8|rcsb pdb:3L9J|rcsb pdb:3WD5|rcsb pdb:4G3Y|rcsb pdb:4TSV|rcsb pdb:4TWT|rcsb pdb:4Y6O|rcsb pdb:5M2I|rcsb pdb:5M2J|rcsb pdb:5M2M|rcsb pdb:5MU8|rcsb pdb:5TSW|rcsb pdb:5WUX|rcsb pdb:5YOY|rcsb pdb:6OOY|rcsb pdb:6OOZ|rcsb pdb:6OP0|rcsb pdb:6RMJ|rcsb pdb:6X81|rcsb pdb:6X82|rcsb pdb:6X83|rcsb pdb:6X85|rcsb pdb:6X86|rcsb pdb:7ASY|rcsb pdb:7AT7|rcsb pdb:7ATB|rcsb pdb:7JRA|rcsb pdb:7KP9|rcsb pdb:7KPA|rcsb pdb:7KPB|reactome:R-HSA-381340|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5626978|rcsb pdb:5UUI|reactome:R-HSA-5668541|reactome:R-HSA-6783783|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071230"(cellular response to amino acid stimulus)|refseq:NP_000585.2|dip:DIP-2895N	interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|refseq:NP_619973.1|dip:DIP-61149N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/04	2017/08/10	rogid:27bbNim4bHFyBJscZC+/v9o96+g9606	rogid:QvBFqjDDTbSuMSOr2qx28gwXZRc10243	rigid:+zVWKVcKvlrlh7msUCyVDhU40qQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P78556	uniprotkb:P0DSV7	intact:EBI-3913209|uniprotkb:Q99664|uniprotkb:Q53S51|ensembl:ENSP00000351671	intact:EBI-15577099|uniprotkb:Q85407|uniprotkb:Q89098|uniprotkb:Q89118|uniprotkb:P34015	psi-mi:ccl20_human(display_long)|uniprotkb:CCL20(gene name)|psi-mi:CCL20(display_short)|uniprotkb:LARC(gene name synonym)|uniprotkb:MIP3A(gene name synonym)|uniprotkb:SCYA20(gene name synonym)|uniprotkb:Beta-chemokine exodus-1(gene name synonym)|uniprotkb:CC chemokine LARC(gene name synonym)|uniprotkb:Liver and activation-regulated chemokine(gene name synonym)|uniprotkb:Macrophage inflammatory protein 3 alpha(gene name synonym)|uniprotkb:Small-inducible cytokine A20(gene name synonym)	psi-mi:crmb_var67(display_long)|uniprotkb:CRMB(gene name)|psi-mi:CRMB(display_short)|uniprotkb:Viral tumor necrosis factor receptor II(gene name synonym)|uniprotkb:G2R(orf name)|uniprotkb:G4R(orf name)	psi-mi:"MI:0107"(surface plasmon resonance)	Alejo et al. (2006)	pubmed:16581912|doi:10.1073/pnas.0510462103|imex:IM-23475	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:587200(varv)|taxid:587200("Variola virus (isolate Human/India/Ind3/1967)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15577588|imex:IM-23475-22|dip:DIP-197592E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001123518.1|refseq:NP_004582.1|ensembl:ENSG00000115009(gene)|ensembl:ENST00000358813(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031731"(CCR6 chemokine receptor binding)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072678"(T cell migration)|go:"GO:0072679"(thymocyte migration)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR034133|interpro:IPR036048|interpro:IPR039809|mint:P78556|rcsb pdb:1M8A|rcsb pdb:2HCI|rcsb pdb:2JYO|rcsb pdb:5UR7|rcsb pdb:6WWZ|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|dip:DIP-5864N	refseq:NP_042240.1|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039553"(suppression by virus of host chemokine activity)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR010806(Protein of unknown function DUF1406)|interpro:IPR011172(TNF-alpha receptor-II, vaccinia C22L type)|interpro:IPR034059|dip:DIP-61146N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/04	2017/08/10	rogid:ZOPQjamFqp/TxK/9rE4YVOUdKEE9606	rogid:BTcFeVFiucw38V1j0MR7Ui2hocA587200	rigid:MemwVC77d0GvTZg0ghPK8AtaVJU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O55038	uniprotkb:Q8QMN0	intact:EBI-7783538|ensembl:ENSMUSP00000023840|intact:UNK-5364318	intact:EBI-15577605	psi-mi:cxl13_mouse(display_long)|uniprotkb:Cxcl13(gene name)|psi-mi:Cxcl13(display_short)|uniprotkb:Blc(gene name synonym)|uniprotkb:Scyb13(gene name synonym)|uniprotkb:Small-inducible cytokine B13(gene name synonym)|uniprotkb:B lymphocyte chemoattractant(gene name synonym)|uniprotkb:CXC chemokine BLC(gene name synonym)	psi-mi:q8qmn0_cwpxb(display_long)|uniprotkb:CPXV218 CDS(gene name)|psi-mi:CPXV218 CDS(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	Alejo et al. (2006)	pubmed:16581912|doi:10.1073/pnas.0510462103|imex:IM-23475	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:265872(cpv)|taxid:265872("Cowpox virus (strain Brighton Red)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15577630|imex:IM-23475-24|dip:DIP-197583E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000023078(gene)|ensembl:ENSMUST00000023840(transcript)|go:"GO:0002518"(lymphocyte chemotaxis across high endothelial venule)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031724"(CXCR5 chemokine receptor binding)|go:"GO:0031735"(CCR10 chemokine receptor binding)|go:"GO:0033625"(positive regulation of integrin activation)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0035754"(B cell chemotaxis)|go:"GO:0035768"(endothelial cell chemotaxis to fibroblast growth factor)|go:"GO:0035769"(B cell chemotaxis across high endothelial venule)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0048535"(lymph node development)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:2000545"(negative regulation of endothelial cell chemotaxis to fibroblast growth factor)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|mint:O55038|rcsb pdb:5IZB|rcsb pdb:5L7M|reactome:R-MMU-380108|reactome:R-MMU-418594|refseq:NP_061354.1|dip:DIP-57395N	interpro:IPR009172(Uncharacterised conserved protein UCP003692, orthopoxvirus C13)|refseq:NP_619998.1|dip:DIP-61150N	psi-mi:"MI:0465"(dip)	comment:mint|function:Strongly chemotactic for B-lymphocytes, weakly for spleen monocytes and macrophages but no chemotactic activity for granulocytes. Binds to BLR1/CXCR5. May play a role in directing the migration of B-lymphocytes to follicles in secondary lymphoid organs	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/04	2017/08/10	rogid:t0RrvxBL8SPEUul/xdwDGEG/IDQ10090	rogid:KaUTMpFLzzTOmjsAquvz764B2F4265872	rigid:xX/vwhhY656Y63Qbav6sxbhO+UQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O35903	uniprotkb:Q8QMN0	intact:EBI-7783383|ensembl:ENSMUSP00000024004|intact:MINT-106264|uniprotkb:Q9QYY6	intact:EBI-15577605	psi-mi:ccl25_mouse(display_long)|uniprotkb:Ccl25(gene name)|psi-mi:Ccl25(display_short)|uniprotkb:Scya25(gene name synonym)|uniprotkb:Teck(gene name synonym)|uniprotkb:Small-inducible cytokine A25(gene name synonym)|uniprotkb:Thymus-expressed chemokine(gene name synonym)|uniprotkb:Chemokine TECK(gene name synonym)	psi-mi:q8qmn0_cwpxb(display_long)|uniprotkb:CPXV218 CDS(gene name)|psi-mi:CPXV218 CDS(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	Alejo et al. (2006)	pubmed:16581912|doi:10.1073/pnas.0510462103|imex:IM-23475	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:265872(cpv)|taxid:265872("Cowpox virus (strain Brighton Red)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15577613|imex:IM-23475-23|dip:DIP-197582E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011240345.2|refseq:XP_011240346.2|ensembl:ENSMUSG00000023235(gene)|ensembl:ENSMUST00000024004(transcript)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031735"(CCR10 chemokine receptor binding)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050900"(leukocyte migration)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR034133|interpro:IPR036048|interpro:IPR039809|mint:O35903|reactome:R-MMU-380108|reactome:R-MMU-418594|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|refseq:NP_033164.1|dip:DIP-5885N	interpro:IPR009172(Uncharacterised conserved protein UCP003692, orthopoxvirus C13)|refseq:NP_619998.1|dip:DIP-61150N	psi-mi:"MI:0465"(dip)	comment:mint|function:Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/04	2017/08/10	rogid:iFXjSeVsixwKlvqlDbax1vvLGCE10090	rogid:KaUTMpFLzzTOmjsAquvz764B2F4265872	rigid:E+b7hZy3Sc1HnE0wahJtJzOgRCU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P47992	uniprotkb:P0DSV7	intact:EBI-10209901|uniprotkb:Q52MA8|ensembl:ENSP00000356792	intact:EBI-15577099|uniprotkb:Q85407|uniprotkb:Q89098|uniprotkb:Q89118|uniprotkb:P34015	psi-mi:xcl1_human(display_long)|uniprotkb:XCL1(gene name)|psi-mi:XCL1(display_short)|uniprotkb:ATAC(gene name synonym)|uniprotkb:C motif chemokine 1(gene name synonym)|uniprotkb:Cytokine SCM-1(gene name synonym)|uniprotkb:LTN(gene name synonym)|uniprotkb:Lymphotaxin(gene name synonym)|uniprotkb:SCM-1-alpha(gene name synonym)|uniprotkb:SCYC1(gene name synonym)|uniprotkb:Small-inducible cytokine C1(gene name synonym)|uniprotkb:XC chemokine ligand 1(gene name synonym)	psi-mi:crmb_var67(display_long)|uniprotkb:CRMB(gene name)|psi-mi:CRMB(display_short)|uniprotkb:Viral tumor necrosis factor receptor II(gene name synonym)|uniprotkb:G2R(orf name)|uniprotkb:G4R(orf name)	psi-mi:"MI:0107"(surface plasmon resonance)	Alejo et al. (2006)	pubmed:16581912|doi:10.1073/pnas.0510462103|imex:IM-23475	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:587200(varv)|taxid:587200("Variola virus (isolate Human/India/Ind3/1967)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15577647|imex:IM-23475-25|dip:DIP-197593E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002986.1|refseq:XP_011508167.1|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071636"(positive regulation of transforming growth factor beta production)|go:"GO:0071663"(positive regulation of granzyme B production)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:2000412"(positive regulation of thymocyte migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|go:"GO:2000513"(positive regulation of granzyme A production)|go:"GO:2000518"(negative regulation of T-helper 1 cell activation)|go:"GO:2000538"(positive regulation of B cell chemotaxis)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|go:"GO:2000556"(positive regulation of T-helper 1 cell cytokine production)|go:"GO:2000558"(positive regulation of immunoglobulin production in mucosal tissue)|go:"GO:2000562"(negative regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2000563"(positive regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2000566"(positive regulation of CD8-positive, alpha-beta T cell proliferation)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR008105(Lymphotactin precursor)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1J8I|rcsb pdb:1J9O|rcsb pdb:2HDM|rcsb pdb:2JP1|rcsb pdb:2N54|rcsb pdb:2NYZ|reactome:R-HSA-380108|reactome:R-HSA-416476|ensembl:ENSG00000143184(gene)|ensembl:ENST00000367818(transcript)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002690"(positive regulation of leukocyte chemotaxis)|go:"GO:0002725"(negative regulation of T cell cytokine production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002826"(negative regulation of T-helper 1 type immune response)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0035782"(mature natural killer cell chemotaxis)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048020"(CCR chemokine receptor binding)|dip:DIP-29876N	refseq:NP_042240.1|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039553"(suppression by virus of host chemokine activity)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR010806(Protein of unknown function DUF1406)|interpro:IPR011172(TNF-alpha receptor-II, vaccinia C22L type)|interpro:IPR034059|dip:DIP-61146N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/04	2017/08/10	rogid:DRRNNQxttFRNuXdLAqzUany8MTQ9606	rogid:BTcFeVFiucw38V1j0MR7Ui2hocA587200	rigid:i4Cv7sgeMmaFfafSo8Po0OmR2fc	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P48061	uniprotkb:P0DSV7	intact:EBI-3913254|uniprotkb:H7BYN8|uniprotkb:B2R4G0|uniprotkb:Q9H554|uniprotkb:E7EVL0|uniprotkb:Q5IT36|uniprotkb:Q2L985|uniprotkb:Q2L986|uniprotkb:Q2L988|uniprotkb:Q6ICW0|ensembl:ENSP00000363551	intact:EBI-15577099|uniprotkb:Q85407|uniprotkb:Q89098|uniprotkb:Q89118|uniprotkb:P34015	psi-mi:sdf1_human(display_long)|uniprotkb:CXCL12(gene name)|psi-mi:CXCL12(display_short)|uniprotkb:SDF1(gene name synonym)|uniprotkb:SDF1A(gene name synonym)|uniprotkb:SDF1B(gene name synonym)|uniprotkb:C-X-C motif chemokine 12(gene name synonym)|uniprotkb:Intercrine reduced in hepatomas(gene name synonym)|uniprotkb:Pre-B cell growth-stimulating factor(gene name synonym)	psi-mi:crmb_var67(display_long)|uniprotkb:CRMB(gene name)|psi-mi:CRMB(display_short)|uniprotkb:Viral tumor necrosis factor receptor II(gene name synonym)|uniprotkb:G2R(orf name)|uniprotkb:G4R(orf name)	psi-mi:"MI:0107"(surface plasmon resonance)	Alejo et al. (2006)	pubmed:16581912|doi:10.1073/pnas.0510462103|imex:IM-23475	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:587200(varv)|taxid:587200("Variola virus (isolate Human/India/Ind3/1967)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15577681|imex:IM-23475-27|dip:DIP-197594E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000600.1|refseq:NP_001029058.1|refseq:NP_954637.1|refseq:NP_001171605.1|refseq:NP_001264919.1|ensembl:ENSG00000107562(gene)|ensembl:ENST00000374429(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001764"(neuron migration)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008083"(growth factor activity)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009314"(response to radiation)|go:"GO:0009408"(response to heat)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0033622"(integrin activation)|go:"GO:0038146"("chemokine (C-X-C motif) ligand 12 signaling pathway")|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0005576"(extracellular region)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|go:"GO:1990478"(response to ultrasound)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR033899|interpro:IPR036048|interpro:IPR039813|rcsb pdb:1A15|rcsb pdb:1QG7|rcsb pdb:1SDF|rcsb pdb:1VMC|rcsb pdb:2K01|rcsb pdb:2K03|rcsb pdb:2K04|rcsb pdb:2K05|rcsb pdb:2KEC|rcsb pdb:2J7Z|rcsb pdb:2KED|rcsb pdb:2KEE|rcsb pdb:2KOL|rcsb pdb:2N55|rcsb pdb:2NWG|rcsb pdb:2SDF|rcsb pdb:3GV3|rcsb pdb:3HP3|rcsb pdb:4LMQ|rcsb pdb:4UAI|rcsb pdb:6SHR|reactome:R-HSA-1251985|reactome:R-HSA-376176|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-9018519|dip:DIP-391N	refseq:NP_042240.1|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039553"(suppression by virus of host chemokine activity)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR010806(Protein of unknown function DUF1406)|interpro:IPR011172(TNF-alpha receptor-II, vaccinia C22L type)|interpro:IPR034059|dip:DIP-61146N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/04	2017/08/10	rogid:DHGsB0zBMh/qkZCgG/n4mAVkfto9606	rogid:BTcFeVFiucw38V1j0MR7Ui2hocA587200	rigid:DPPjyhUs2Cho1RlmafTQsSOw4OM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O43927	uniprotkb:P0DSV7	intact:EBI-719170|ensembl:ENSP00000507688|ensembl:ENSP00000286758	intact:EBI-15577099|uniprotkb:Q85407|uniprotkb:Q89098|uniprotkb:Q89118|uniprotkb:P34015	psi-mi:cxl13_human(display_long)|uniprotkb:Small-inducible cytokine B13(gene name synonym)|uniprotkb:B lymphocyte chemoattractant(gene name synonym)|uniprotkb:CXC chemokine BLC(gene name synonym)|uniprotkb:B cell-attracting chemokine 1(gene name synonym)|uniprotkb:CXCL13(gene name)|psi-mi:CXCL13(display_short)|uniprotkb:BCA1(gene name synonym)|uniprotkb:BLC(gene name synonym)|uniprotkb:SCYB13(gene name synonym)|uniprotkb:Angie(gene name synonym)	psi-mi:crmb_var67(display_long)|uniprotkb:CRMB(gene name)|psi-mi:CRMB(display_short)|uniprotkb:Viral tumor necrosis factor receptor II(gene name synonym)|uniprotkb:G2R(orf name)|uniprotkb:G4R(orf name)	psi-mi:"MI:0107"(surface plasmon resonance)	Alejo et al. (2006)	pubmed:16581912|doi:10.1073/pnas.0510462103|imex:IM-23475	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:587200(varv)|taxid:587200("Variola virus (isolate Human/India/Ind3/1967)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15577664|imex:IM-23475-26|dip:DIP-197595E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006410.1|go:"GO:0008201"(heparin binding)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031724"(CXCR5 chemokine receptor binding)|go:"GO:0031735"(CCR10 chemokine receptor binding)|go:"GO:0033625"(positive regulation of integrin activation)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0035754"(B cell chemotaxis)|go:"GO:0035768"(endothelial cell chemotaxis to fibroblast growth factor)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:2000545"(negative regulation of endothelial cell chemotaxis to fibroblast growth factor)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|rcsb pdb:5CBA|rcsb pdb:5CBE|rcsb pdb:6VGJ|rcsb pdb:7JNY|reactome:R-HSA-380108|reactome:R-HSA-418594|ensembl:ENST00000286758(transcript)|ensembl:ENST00000682537(transcript)|go:"GO:0002467"(germinal center formation)|go:"GO:0002518"(lymphocyte chemotaxis across high endothelial venule)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0002920"(regulation of humoral immune response)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|refseq:XP_006714126.1|ensembl:ENSG00000156234(gene)|dip:DIP-5914N	refseq:NP_042240.1|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039553"(suppression by virus of host chemokine activity)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR010806(Protein of unknown function DUF1406)|interpro:IPR011172(TNF-alpha receptor-II, vaccinia C22L type)|interpro:IPR034059|dip:DIP-61146N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/04	2017/08/10	rogid:5/65nY3r+t/6Br3fQLOX+1JENJQ9606	rogid:BTcFeVFiucw38V1j0MR7Ui2hocA587200	rigid:zInGYzlHQl98zn+Qlw9zw+nZWpE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P40224	uniprotkb:Q8QMN0	intact:EBI-15577217|ensembl:ENSMUSP00000108492|uniprotkb:Q4FJL5|uniprotkb:Q543V6	intact:EBI-15577605	psi-mi:sdf1_mouse(display_long)|uniprotkb:Cxcl12(gene name)|psi-mi:Cxcl12(display_short)|uniprotkb:Sdf1(gene name synonym)|uniprotkb:12-O-tetradecanoylphorbol 13-acetate repressed protein 1(gene name synonym)|uniprotkb:C-X-C motif chemokine 12(gene name synonym)|uniprotkb:Pre-B cell growth-stimulating factor(gene name synonym)|uniprotkb:Thymic lymphoma cell-stimulating factor(gene name synonym)	psi-mi:q8qmn0_cwpxb(display_long)|uniprotkb:CPXV218 CDS(gene name)|psi-mi:CPXV218 CDS(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	Alejo et al. (2006)	pubmed:16581912|doi:10.1073/pnas.0510462103|imex:IM-23475	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:265872(cpv)|taxid:265872("Cowpox virus (strain Brighton Red)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15577698|imex:IM-23475-28|dip:DIP-197584E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000061353(gene)|ensembl:ENSMUST00000112871(transcript)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001667"(ameboidal-type cell migration)|go:"GO:0001764"(neuron migration)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006952"(defense response)|go:"GO:0007281"(germ cell development)|go:"GO:0007411"(axon guidance)|go:"GO:0007420"(brain development)|go:"GO:0008009"(chemokine activity)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008354"(germ cell migration)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0033622"(integrin activation)|go:"GO:0038146"("chemokine (C-X-C motif) ligand 12 signaling pathway")|go:"GO:0042098"(T cell proliferation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR033899|interpro:IPR036048|interpro:IPR039813|reactome:R-MMU-376176|reactome:R-MMU-380108|reactome:R-MMU-418594|refseq:NP_038683.1|refseq:NP_068350.1|dip:DIP-61153N	interpro:IPR009172(Uncharacterised conserved protein UCP003692, orthopoxvirus C13)|refseq:NP_619998.1|dip:DIP-61150N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/04	2017/08/10	rogid:tp7XTOFjPVKpUvXIIFJLWzusAxI10090	rogid:KaUTMpFLzzTOmjsAquvz764B2F4265872	rigid:5PWzCMcqLu5kDs4JYQ/oCy6G4eE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)