#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P42226 uniprotkb:Q460N5 intact:EBI-1186478|uniprotkb:Q5FBW5|uniprotkb:Q71UP4|uniprotkb:A8K316|uniprotkb:B7ZA27|uniprotkb:F5GXI9|intact:EBI-28971408|ensembl:ENSP00000300134|ensembl:ENSP00000401486|ensembl:ENSP00000438451|ensembl:ENSP00000451742 intact:EBI-15575162|ensembl:ENSP00000418194|uniprotkb:B4E2H0|uniprotkb:Q460N4|uniprotkb:Q8J027|uniprotkb:Q9H9X9|uniprotkb:Q9NV60|uniprotkb:Q9ULF2 psi-mi:stat6_human(display_long)|uniprotkb:IL-4 Stat(gene name synonym)|uniprotkb:STAT6(gene name)|psi-mi:STAT6(display_short) psi-mi:par14_human(display_long)|uniprotkb:Poly [ADP-ribose] polymerase 14(gene name synonym)|uniprotkb:PARP14(gene name)|psi-mi:PARP14(display_short)|uniprotkb:BAL2(gene name synonym)|uniprotkb:KIAA1268(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 8(gene name synonym)|uniprotkb:B aggressive lymphoma protein 2(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Goenka et al. (2006) pubmed:16537510|doi:10.1073/pnas.0506981103|imex:IM-23456 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15575212|imex:IM-23456-1|dip:DIP-197535E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000300134|ensembl:ENSP00000401486|ensembl:ENST00000537215|ensembl:ENSP00000444530|ensembl:ENST00000538913|ensembl:ENSP00000445409|ensembl:ENSP00000438451|ensembl:ENSP00000451742|refseq:NP_001171549.1|refseq:NP_001171550.1|refseq:NP_003144.3|refseq:XP_006719638.1|refseq:NP_001171551.1|ensembl:ENSG00000166888(gene)|ensembl:ENST00000300134(transcript)|ensembl:ENST00000454075(transcript)|ensembl:ENST00000543873(transcript)|ensembl:ENST00000556155(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002296"(T-helper 1 cell lineage commitment)|go:"GO:0002829"(negative regulation of type 2 immune response)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006952"(defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0035771"(interleukin-4-mediated signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048295"(positive regulation of isotype switching to IgE isotypes)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0060443"(mammary gland morphogenesis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1902170"(cellular response to reactive nitrogen species)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR028187|interpro:IPR035857|interpro:IPR036535|interpro:IPR036860|mint:P42226|rcsb pdb:1OJ5|rcsb pdb:4Y5U|rcsb pdb:4Y5W|rcsb pdb:5D39|rcsb pdb:5NWM|rcsb pdb:5NWX|reactome:R-HSA-186763|reactome:R-HSA-3249367|reactome:R-HSA-6785807|dip:DIP-39855N ensembl:ENSG00000173193(gene)|ensembl:ENST00000474629(transcript)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0060336"(negative regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0070212"(protein poly-ADP-ribosylation)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0070403"(NAD+ binding)|go:"GO:0140289"(protein mono-ADP-ribosylation)|go:"GO:0016020"(membrane)|go:"GO:1902216"(positive regulation of interleukin-4-mediated signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:1990404"(protein ADP-ribosylase activity)|interpro:IPR002589(Appr-1-p processing)|go:"GO:0045087"(innate immune response)|interpro:IPR004170(WWE)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034517|interpro:IPR037197|interpro:IPR043472|mint:Q460N5|rcsb pdb:3GOY|rcsb pdb:3Q6Z|rcsb pdb:3Q71|rcsb pdb:3SE2|rcsb pdb:3SMI|rcsb pdb:3SMJ|rcsb pdb:3VFQ|rcsb pdb:4ABK|rcsb pdb:4ABL|rcsb pdb:4D86|rcsb pdb:4F1L|rcsb pdb:4F1Q|rcsb pdb:4PY4|rcsb pdb:5LXP|rcsb pdb:5LYH|rcsb pdb:5NQE|rcsb pdb:5O2D|rcsb pdb:5QHT|rcsb pdb:5QHU|rcsb pdb:5QHV|rcsb pdb:5QHW|rcsb pdb:5QHX|rcsb pdb:5QHY|rcsb pdb:5QHZ|rcsb pdb:5QI0|rcsb pdb:5QI1|rcsb pdb:5QI2|rcsb pdb:5QI3|rcsb pdb:5QI4|rcsb pdb:5QI5|rcsb pdb:5QI6|rcsb pdb:5QI7|rcsb pdb:5QI8|rcsb pdb:5QI9|rcsb pdb:5QIA|rcsb pdb:5V7T|rcsb pdb:5V7W|rcsb pdb:6FYM|rcsb pdb:6FZM|rcsb pdb:6G0W|rcsb pdb:6WE2|rcsb pdb:6WE3|rcsb pdb:6WE4|rcsb pdb:7D2C|rcsb pdb:7L9Y|rcsb pdb:7LUN|reactome:R-HSA-197264|reactome:R-HSA-9683610|reactome:R-HSA-9694631|refseq:NP_060024.2|dip:DIP-61130N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/04 2017/08/10 rogid:BuSBP6PMmA3hcOmnaH3/r4XoiVw9606 rogid:wNYDgvryexaU14HiLwBsNJYxMFU9606 rigid:DAgTJWnEoXl2wC81/5goWc31Ivk false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P52633 uniprotkb:Q2EMV9 intact:EBI-647085|uniprotkb:Q8R2F1|ensembl:ENSMUSP00000089708 intact:EBI-1534943|uniprotkb:Q571C6|uniprotkb:Q8BN35|uniprotkb:Q8VDT6|uniprotkb:E9QP48|ensembl:ENSMUSP00000037657 psi-mi:stat6_mouse(display_long)|uniprotkb:Stat6(gene name)|psi-mi:Stat6(display_short) psi-mi:par14_mouse(display_long)|uniprotkb:Parp14(gene name)|psi-mi:Parp14(display_short)|uniprotkb:Kiaa1268(gene name synonym)|uniprotkb:Collaborator of STAT6(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 8(gene name synonym)|uniprotkb:Poly [ADP-ribose] polymerase 14(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Goenka et al. (2006) pubmed:16537510|doi:10.1073/pnas.0506981103|imex:IM-23456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15575246|imex:IM-23456-3|dip:DIP-197536E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033310.2|dip:DIP-49680N|ensembl:ENSMUSG00000002147(gene)|ensembl:ENSMUST00000092074(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002296"(T-helper 1 cell lineage commitment)|go:"GO:0002829"(negative regulation of type 2 immune response)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006952"(defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034097"(response to cytokine)|go:"GO:0035771"(interleukin-4-mediated signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048295"(positive regulation of isotype switching to IgE isotypes)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0060443"(mammary gland morphogenesis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1902170"(cellular response to reactive nitrogen species)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR028187|interpro:IPR035857|interpro:IPR036535|interpro:IPR036860|reactome:R-MMU-186763|reactome:R-MMU-3249367|reactome:R-MMU-6785807 refseq:NP_001034619.2|dip:DIP-38053N|ensembl:ENSMUSG00000034422(gene)|ensembl:ENSMUST00000042665(transcript)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019899"(enzyme binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0045087"(innate immune response)|go:"GO:0060336"(negative regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0070212"(protein poly-ADP-ribosylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0140289"(protein mono-ADP-ribosylation)|go:"GO:1902216"(positive regulation of interleukin-4-mediated signaling pathway)|go:"GO:1990404"(protein ADP-ribosylase activity)|interpro:IPR002589(Appr-1-p processing)|interpro:IPR004170(WWE)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034517|interpro:IPR037197|interpro:IPR043472|rcsb pdb:1X4R|reactome:R-MMU-197264 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/04 2017/08/10 rogid:m07k8wM7HDHszNbxbEL8Yu2oDYE10090 rogid:B38McmWStIPDwecAtDvlqFQswGg10090 rigid:vQPYH9DgCWLpH03cvukCw+vFeMY false - flag tag:n-n - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P52633 uniprotkb:Q2EMV9 intact:EBI-647085|uniprotkb:Q8R2F1|ensembl:ENSMUSP00000089708 intact:EBI-1534943|uniprotkb:Q571C6|uniprotkb:Q8BN35|uniprotkb:Q8VDT6|uniprotkb:E9QP48|ensembl:ENSMUSP00000037657 psi-mi:stat6_mouse(display_long)|uniprotkb:Stat6(gene name)|psi-mi:Stat6(display_short) psi-mi:par14_mouse(display_long)|uniprotkb:Parp14(gene name)|psi-mi:Parp14(display_short)|uniprotkb:Kiaa1268(gene name synonym)|uniprotkb:Collaborator of STAT6(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 8(gene name synonym)|uniprotkb:Poly [ADP-ribose] polymerase 14(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Goenka et al. (2006) pubmed:16537510|doi:10.1073/pnas.0506981103|imex:IM-23456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15575229|imex:IM-23456-2|dip:DIP-197536E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033310.2|dip:DIP-49680N|ensembl:ENSMUSG00000002147(gene)|ensembl:ENSMUST00000092074(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002296"(T-helper 1 cell lineage commitment)|go:"GO:0002829"(negative regulation of type 2 immune response)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006952"(defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034097"(response to cytokine)|go:"GO:0035771"(interleukin-4-mediated signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048295"(positive regulation of isotype switching to IgE isotypes)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0060443"(mammary gland morphogenesis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1902170"(cellular response to reactive nitrogen species)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR028187|interpro:IPR035857|interpro:IPR036535|interpro:IPR036860|reactome:R-MMU-186763|reactome:R-MMU-3249367|reactome:R-MMU-6785807 refseq:NP_001034619.2|dip:DIP-38053N|ensembl:ENSMUSG00000034422(gene)|ensembl:ENSMUST00000042665(transcript)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019899"(enzyme binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0045087"(innate immune response)|go:"GO:0060336"(negative regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0070212"(protein poly-ADP-ribosylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0140289"(protein mono-ADP-ribosylation)|go:"GO:1902216"(positive regulation of interleukin-4-mediated signaling pathway)|go:"GO:1990404"(protein ADP-ribosylase activity)|interpro:IPR002589(Appr-1-p processing)|interpro:IPR004170(WWE)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034517|interpro:IPR037197|interpro:IPR043472|rcsb pdb:1X4R|reactome:R-MMU-197264 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse)|taxid:10090(Mus musculus) - 2017/08/04 2017/08/10 rogid:m07k8wM7HDHszNbxbEL8Yu2oDYE10090 rogid:B38McmWStIPDwecAtDvlqFQswGg10090 rigid:vQPYH9DgCWLpH03cvukCw+vFeMY false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P52633 uniprotkb:Q2EMV9 intact:EBI-647085|uniprotkb:Q8R2F1|ensembl:ENSMUSP00000089708 intact:EBI-1534943|uniprotkb:Q571C6|uniprotkb:Q8BN35|uniprotkb:Q8VDT6|uniprotkb:E9QP48|ensembl:ENSMUSP00000037657 psi-mi:stat6_mouse(display_long)|uniprotkb:Stat6(gene name)|psi-mi:Stat6(display_short) psi-mi:par14_mouse(display_long)|uniprotkb:Parp14(gene name)|psi-mi:Parp14(display_short)|uniprotkb:Kiaa1268(gene name synonym)|uniprotkb:Collaborator of STAT6(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 8(gene name synonym)|uniprotkb:Poly [ADP-ribose] polymerase 14(gene name synonym) psi-mi:"MI:0018"(two hybrid) Goenka et al. (2006) pubmed:16537510|doi:10.1073/pnas.0506981103|imex:IM-23456 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15575265|imex:IM-23456-4|dip:DIP-197536E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033310.2|dip:DIP-49680N|ensembl:ENSMUSG00000002147(gene)|ensembl:ENSMUST00000092074(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002296"(T-helper 1 cell lineage commitment)|go:"GO:0002829"(negative regulation of type 2 immune response)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006952"(defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034097"(response to cytokine)|go:"GO:0035771"(interleukin-4-mediated signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048295"(positive regulation of isotype switching to IgE isotypes)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0060443"(mammary gland morphogenesis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1902170"(cellular response to reactive nitrogen species)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR028187|interpro:IPR035857|interpro:IPR036535|interpro:IPR036860|reactome:R-MMU-186763|reactome:R-MMU-3249367|reactome:R-MMU-6785807 refseq:NP_001034619.2|dip:DIP-38053N|ensembl:ENSMUSG00000034422(gene)|ensembl:ENSMUST00000042665(transcript)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019899"(enzyme binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0045087"(innate immune response)|go:"GO:0060336"(negative regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0070212"(protein poly-ADP-ribosylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0140289"(protein mono-ADP-ribosylation)|go:"GO:1902216"(positive regulation of interleukin-4-mediated signaling pathway)|go:"GO:1990404"(protein ADP-ribosylase activity)|interpro:IPR002589(Appr-1-p processing)|interpro:IPR004170(WWE)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034517|interpro:IPR037197|interpro:IPR043472|rcsb pdb:1X4R|reactome:R-MMU-197264 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/04 2017/08/10 rogid:m07k8wM7HDHszNbxbEL8Yu2oDYE10090 rogid:B38McmWStIPDwecAtDvlqFQswGg10090 rigid:vQPYH9DgCWLpH03cvukCw+vFeMY false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)