#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P51812	uniprotkb:P28223-1	intact:EBI-1046616|ensembl:ENSP00000368884|uniprotkb:Q4VAP3|uniprotkb:Q59H26|uniprotkb:Q5JPK8|uniprotkb:Q7Z3Z7|uniprotkb:B2R9V4	intact:EBI-15573967|ensembl:ENSP00000437737	psi-mi:ks6a3_human(display_long)|uniprotkb:Insulin-stimulated protein kinase 1(gene name synonym)|uniprotkb:MAP kinase-activated protein kinase 1b(gene name synonym)|uniprotkb:90 kDa ribosomal protein S6 kinase 3(gene name synonym)|uniprotkb:MAPKAPK1B(gene name synonym)|uniprotkb:Ribosomal S6 kinase 2(gene name synonym)|uniprotkb:pp90RSK2(gene name synonym)|uniprotkb:RPS6KA3(gene name)|psi-mi:RPS6KA3(display_short)|uniprotkb:ISPK1(gene name synonym)|uniprotkb:RSK2(gene name synonym)	psi-mi:p28223-1(display_long)|uniprotkb:HTR2A(gene name)|psi-mi:HTR2A(display_short)|uniprotkb:HTR2(gene name synonym)|uniprotkb:Serotonin receptor 2A(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Sheffler et al. (2006)	pubmed:16537434|doi:10.1073/pnas.0600585103|imex:IM-23461	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15573976|imex:IM-23461-1|dip:DIP-197540E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007417"(central nervous system development)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043555"(regulation of translation in response to stress)|go:"GO:0043620"(regulation of DNA-templated transcription in response to stress)|go:"GO:0045202"(synapse)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016239(Ribosomal protein S6 kinase II)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|ensembl:ENSG00000177189(gene)|ensembl:ENST00000379565(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004711"(ribosomal protein S6 kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|refseq:NP_004577.1|interpro:IPR041905|interpro:IPR041906|mint:P51812|rcsb pdb:4D9T|rcsb pdb:4D9U|rcsb pdb:4JG6|rcsb pdb:4JG7|rcsb pdb:4JG8|rcsb pdb:4NUS|rcsb pdb:4NW5|rcsb pdb:4NW6|rcsb pdb:5D9K|rcsb pdb:5D9L|reactome:R-HSA-198753|reactome:R-HSA-199920|reactome:R-HSA-2559582|reactome:R-HSA-437239|reactome:R-HSA-442742|reactome:R-HSA-444257|reactome:R-HSA-881907|dip:DIP-38247N	ensembl:ENSG00000102468(gene)|ensembl:ENST00000542664(transcript)|intact:EBI-6656333(isoform-parent)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/08/04	2017/08/10	rogid:zkX8NPvSEjVEap7TxboH2SKy9zg9606	rogid:wwxBh+3zPyTL6rfTCnViWTHndzo9606	rigid:aIKGpCpjWXFzhfDAHi01rAQvbyg	false	-	sufficient binding region:255-324	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P53041	uniprotkb:P28223-1	intact:EBI-716663|uniprotkb:Q53XV2|uniprotkb:Q16722|ensembl:ENSP00000012443	intact:EBI-15573967|ensembl:ENSP00000437737	psi-mi:ppp5_human(display_long)|uniprotkb:Protein phosphatase T(gene name synonym)|uniprotkb:PPP5C(gene name)|psi-mi:PPP5C(display_short)|uniprotkb:PPP5(gene name synonym)	psi-mi:p28223-1(display_long)|uniprotkb:HTR2A(gene name)|psi-mi:HTR2A(display_short)|uniprotkb:HTR2(gene name synonym)|uniprotkb:Serotonin receptor 2A(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Sheffler et al. (2006)	pubmed:16537434|doi:10.1073/pnas.0600585103|imex:IM-23461	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15574014|imex:IM-23461-3|dip:DIP-197549E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006238.1|ensembl:ENSG00000011485(gene)|ensembl:ENST00000012443(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008017"(microtubule binding)|go:"GO:0008289"(lipid binding)|go:"GO:0010288"(response to lead ion)|go:"GO:0016576"(histone dephosphorylation)|go:"GO:0016791"(phosphatase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043278"(response to morphine)|go:"GO:0043531"(ADP binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0101031"(chaperone complex)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1904550"(response to arachidonic acid)|go:"GO:1990635"(proximal dendrite)|go:"GO:2000324"(positive regulation of glucocorticoid receptor signaling pathway)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR011236(Protein phosphatase 5)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013235(Serine/threonine phosphatase, PPP5)|interpro:IPR019734|interpro:IPR029052|interpro:IPR041753|mint:P53041|rcsb pdb:1A17|rcsb pdb:1S95|rcsb pdb:1WAO|rcsb pdb:2BUG|rcsb pdb:3H60|rcsb pdb:3H61|rcsb pdb:3H62|rcsb pdb:3H63|rcsb pdb:3H64|rcsb pdb:3H66|rcsb pdb:3H67|rcsb pdb:3H68|rcsb pdb:3H69|rcsb pdb:4ZVZ|rcsb pdb:4ZX2|rcsb pdb:5HPE|rcsb pdb:5UI1|rcsb pdb:5WG8|reactome:R-HSA-5675221|reactome:R-HSA-5693565|reactome:R-HSA-8939211|dip:DIP-29043N	ensembl:ENSG00000102468(gene)|ensembl:ENST00000542664(transcript)|intact:EBI-6656333(isoform-parent)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/08/04	2017/08/10	rogid:5QoNB467ftOvWaUNfSm6RalR8+Y9606	rogid:wwxBh+3zPyTL6rfTCnViWTHndzo9606	rigid:jj1rGAFb/3ViduAj7het/IxLevY	false	-	sufficient binding region:255-324	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q15165	uniprotkb:P28223-1	intact:EBI-3909798|ensembl:ENSP00000222572|ensembl:ENSP00000488838|uniprotkb:O15114|uniprotkb:B4DJD5|uniprotkb:Q5FBX7|uniprotkb:O15115|uniprotkb:B2RCP9|uniprotkb:Q86YL0|uniprotkb:O75856|uniprotkb:A4D1H7|intact:EBI-10966394	intact:EBI-15573967|ensembl:ENSP00000437737	psi-mi:pon2_human(display_long)|uniprotkb:PON2(gene name)|psi-mi:PON2(display_short)|uniprotkb:Aromatic esterase 2(gene name synonym)|uniprotkb:Serum aryldialkylphosphatase 2(gene name synonym)	psi-mi:p28223-1(display_long)|uniprotkb:HTR2A(gene name)|psi-mi:HTR2A(display_short)|uniprotkb:HTR2(gene name synonym)|uniprotkb:Serotonin receptor 2A(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Sheffler et al. (2006)	pubmed:16537434|doi:10.1073/pnas.0600585103|imex:IM-23461	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15574033|imex:IM-23461-4|dip:DIP-197545E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000105854(gene)|ensembl:ENST00000222572(transcript)|ensembl:ENST00000633531(transcript)|go:"GO:0004064"(arylesterase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0009636"(response to toxic substance)|go:"GO:0019439"(aromatic compound catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0102007"(acyl-L-homoserine-lactone lactonohydrolase activity)|interpro:IPR002640(Arylesterase)|interpro:IPR008364(Paraoxonase2)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|mint:Q15165|reactome:R-HSA-2142688|refseq:NP_000296.2|dip:DIP-61136N|refseq:NP_001018171.1	ensembl:ENSG00000102468(gene)|ensembl:ENST00000542664(transcript)|intact:EBI-6656333(isoform-parent)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/08/04	2018/04/06	rogid:9zE87aut0R8eYxaXM+HgYsJxLYI9606	rogid:wwxBh+3zPyTL6rfTCnViWTHndzo9606	rigid:tlraDN9va/TZsR2WDiHtvp1IQVE	false	-	sufficient binding region:255-324	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q7Z6G8	uniprotkb:P28223-1	intact:EBI-7876312|uniprotkb:Q5XLJ0|intact:MINT-4903813|intact:MINT-4918769|uniprotkb:B4DH98|uniprotkb:A5PKY5|uniprotkb:F8VZR9|uniprotkb:F8VPM3|uniprotkb:A8MSN4|uniprotkb:A8K153|uniprotkb:Q6NUS4|intact:MINT-1492880|uniprotkb:Q7Z6G7|uniprotkb:Q6IVB5|uniprotkb:A7E259|uniprotkb:Q7Z6G6|uniprotkb:Q8TAP3|intact:MINT-258807|uniprotkb:F8WC27|uniprotkb:Q9NRX7|uniprotkb:Q9Y5K9|uniprotkb:B4DFP6|ensembl:ENSP00000449629	intact:EBI-15573967|ensembl:ENSP00000437737	psi-mi:ans1b_human(display_long)|uniprotkb:ANKS1B(gene name)|psi-mi:ANKS1B(display_short)|uniprotkb:Amyloid-beta protein intracellular domain-associated protein 1(gene name synonym)|uniprotkb:E2A-PBX1-associated protein(gene name synonym)	psi-mi:p28223-1(display_long)|uniprotkb:HTR2A(gene name)|psi-mi:HTR2A(display_short)|uniprotkb:HTR2(gene name synonym)|uniprotkb:Serotonin receptor 2A(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Sheffler et al. (2006)	pubmed:16537434|doi:10.1073/pnas.0600585103|imex:IM-23461	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15574052|imex:IM-23461-5|dip:DIP-197541E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001190994.1|refseq:NP_064525.1|refseq:NP_001191008.1|refseq:NP_001191009.1|refseq:NP_001191010.1|refseq:NP_001190999.1|refseq:NP_001190995.1|refseq:NP_001190996.1|refseq:NP_001190998.1|refseq:NP_001190997.1|refseq:NP_690001.3|refseq:NP_858056.2|ensembl:ENSG00000185046(gene)|ensembl:ENST00000547776(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:1900383"(regulation of synaptic plasticity by receptor localization to synapse)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR033636|interpro:IPR036770|interpro:IPR041880|interpro:IPR041882|rcsb pdb:2EAM|rcsb pdb:2KE7|rcsb pdb:2KIV|rcsb pdb:2M38|dip:DIP-41406N	ensembl:ENSG00000102468(gene)|ensembl:ENST00000542664(transcript)|intact:EBI-6656333(isoform-parent)	psi-mi:"MI:0465"(dip)	function:Isoform 2 may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells|function:Isoform 3 can regulate global protein synthesis by altering nucleolar numbers|function:Isoform 4 may play a role as a modulator of APP processing. Overexpression of isoform 4 can down-regulate APP processing|comment:mint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/08/04	2017/08/10	rogid:S/D2te61NTyW2f9ivzPFqIB1/NM9606	rogid:wwxBh+3zPyTL6rfTCnViWTHndzo9606	rigid:JZ/EhKPw83FhRLa8b13IVrSFDm4	false	-	sufficient binding region:255-324	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P15104	uniprotkb:P28223-1	intact:EBI-746653|uniprotkb:Q499Y9|uniprotkb:Q5T9Z1|uniprotkb:Q7Z3W4|uniprotkb:Q8IZ17|ensembl:ENSP00000307900|ensembl:ENSP00000344958|ensembl:ENSP00000356537|ensembl:ENSP00000398320	intact:EBI-15573967|ensembl:ENSP00000437737	psi-mi:glna_human(display_long)|uniprotkb:Glutamate--ammonia ligase(gene name synonym)|uniprotkb:GLUL(gene name)|psi-mi:GLUL(display_short)|uniprotkb:GLNS(gene name synonym)|uniprotkb:Palmitoyltransferase GLUL(gene name synonym)	psi-mi:p28223-1(display_long)|uniprotkb:HTR2A(gene name)|psi-mi:HTR2A(display_short)|uniprotkb:HTR2(gene name synonym)|uniprotkb:Serotonin receptor 2A(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Sheffler et al. (2006)	pubmed:16537434|doi:10.1073/pnas.0600585103|imex:IM-23461	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15573995|imex:IM-23461-2|dip:DIP-197550E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001028216.1|refseq:NP_001028228.1|refseq:NP_002056.2|rcsb pdb:2QC8|reactome:R-HSA-210455|reactome:R-HSA-8964539|rcsb pdb:2OJW|ensembl:ENSG00000135821(gene)|ensembl:ENST00000311223(transcript)|ensembl:ENST00000331872(transcript)|ensembl:ENST00000339526(transcript)|ensembl:ENST00000417584(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001525"(angiogenesis)|go:"GO:0004356"(glutamate-ammonia ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006542"(glutamine biosynthetic process)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009749"(response to glucose)|go:"GO:0010594"(regulation of endothelial cell migration)|go:"GO:0016595"(glutamate binding)|go:"GO:0018345"(protein palmitoylation)|go:"GO:0019676"(ammonia assimilation cycle)|go:"GO:0019706"(protein-cysteine S-palmitoyltransferase activity)|go:"GO:0030145"(manganese ion binding)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043209"(myelin sheath)|go:"GO:0043679"(axon terminus)|go:"GO:0045503"(dynein light chain binding)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097386"(glial cell projection)|go:"GO:1903670"(regulation of sprouting angiogenesis)|go:"GO:1904749"(regulation of protein localization to nucleolus)|interpro:IPR008146(Glutamine synthetase, catalytic region)|interpro:IPR008147(Glutamine synthetase, beta-Grasp)|interpro:IPR014746(Glutamine synthetase/guanido kinase, catalytic region)|interpro:IPR027302|interpro:IPR027303|interpro:IPR036651|mint:P15104|go:"GO:0006538"(glutamate catabolic process)|refseq:XP_006711341.1|dip:DIP-308N	ensembl:ENSG00000102468(gene)|ensembl:ENST00000542664(transcript)|intact:EBI-6656333(isoform-parent)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/08/04	2017/08/10	rogid:UOOgfw1g+kmpsEx64pUbW9GfmYw9606	rogid:wwxBh+3zPyTL6rfTCnViWTHndzo9606	rigid:YlAJ7tSA4+p8N0SkV0FQfe2kGY0	false	-	sufficient binding region:255-324	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P78559	uniprotkb:P28223-1	intact:EBI-929047|uniprotkb:O95643|uniprotkb:Q12973|uniprotkb:Q15882|uniprotkb:Q9UJT4|ensembl:ENSP00000300231	intact:EBI-15573967|ensembl:ENSP00000437737	psi-mi:map1a_human(display_long)|uniprotkb:MAP1A(gene name)|psi-mi:MAP1A(display_short)|uniprotkb:Proliferation-related protein p80(gene name synonym)|uniprotkb:MAP1L(gene name synonym)	psi-mi:p28223-1(display_long)|uniprotkb:HTR2A(gene name)|psi-mi:HTR2A(display_short)|uniprotkb:HTR2(gene name synonym)|uniprotkb:Serotonin receptor 2A(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Sheffler et al. (2006)	pubmed:16537434|doi:10.1073/pnas.0600585103|imex:IM-23461	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15574071|imex:IM-23461-6|dip:DIP-197546E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000300231|refseq:NP_002364.5|dip:DIP-36377N|ensembl:ENSG00000166963(gene)|ensembl:ENST00000300231(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0003779"(actin binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0007409"(axonogenesis)|go:"GO:0007613"(memory)|go:"GO:0008017"(microtubule binding)|go:"GO:0008093"(cytoskeletal anchor activity)|go:"GO:0008306"(associative learning)|go:"GO:0015631"(tubulin binding)|go:"GO:0016358"(dendrite development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031114"(regulation of microtubule depolymerization)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043194"(axon initial segment)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044307"(dendritic branch)|go:"GO:0045202"(synapse)|go:"GO:0048156"(tau protein binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:0099642"(retrograde axonal protein transport)|go:"GO:0150001"(primary dendrite)|go:"GO:1901588"(dendritic microtubule)|go:"GO:1902817"(negative regulation of protein localization to microtubule)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1990535"(neuron projection maintenance)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR015656(MAP1A)|interpro:IPR026074|interpro:IPR036866|mint:P78559	ensembl:ENSG00000102468(gene)|ensembl:ENST00000542664(transcript)|intact:EBI-6656333(isoform-parent)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/08/04	2017/08/10	rogid:lj3f+wL17n1HzPdo9c+15/9Uv0o9606	rogid:wwxBh+3zPyTL6rfTCnViWTHndzo9606	rigid:FKR8oz4Wylv+5Ig6NvZOK5zYI5g	false	-	sufficient binding region:255-324	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P18654	uniprotkb:P28223-1	intact:EBI-397744|ensembl:ENSMUSP00000033671|uniprotkb:Q03140|uniprotkb:Q8K3J8|uniprotkb:B1AXN4	intact:EBI-15573967|ensembl:ENSP00000437737	psi-mi:ks6a3_mouse(display_long)|uniprotkb:Rps6ka3(gene name)|psi-mi:Rps6ka3(display_short)|uniprotkb:Rps6ka-rs1(gene name synonym)|uniprotkb:Rsk2(gene name synonym)|uniprotkb:90 kDa ribosomal protein S6 kinase 3(gene name synonym)|uniprotkb:Mapkapk1b(gene name synonym)|uniprotkb:Ribosomal S6 kinase 2(gene name synonym)|uniprotkb:pp90RSK2(gene name synonym)|uniprotkb:MAP kinase-activated protein kinase 1b(gene name synonym)	psi-mi:p28223-1(display_long)|uniprotkb:HTR2A(gene name)|psi-mi:HTR2A(display_short)|uniprotkb:HTR2(gene name synonym)|uniprotkb:Serotonin receptor 2A(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Sheffler et al. (2006)	pubmed:16537434|doi:10.1073/pnas.0600585103|imex:IM-23461	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15574090|imex:IM-23461-7|dip:DIP-197551E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000031309(gene)|ensembl:ENSMUST00000033671(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004711"(ribosomal protein S6 kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016239(Ribosomal protein S6 kinase II)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR041905|interpro:IPR041906|mint:P18654|rcsb pdb:2QR7|rcsb pdb:2QR8|rcsb pdb:3G51|rcsb pdb:3UBD|rcsb pdb:4EL9|rcsb pdb:4GUE|rcsb pdb:4M8T|rcsb pdb:4MAO|rcsb pdb:5O1S|reactome:R-MMU-198753|reactome:R-MMU-199920|reactome:R-MMU-2559582|reactome:R-MMU-442742|reactome:R-MMU-444257|reactome:R-MMU-881907|refseq:NP_683747.1|dip:DIP-31554N	ensembl:ENSG00000102468(gene)|ensembl:ENST00000542664(transcript)|intact:EBI-6656333(isoform-parent)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/08/04	2017/08/10	rogid:5h7ZnIO/ZD+MvfouRrhQzWM3Q0010090	rogid:wwxBh+3zPyTL6rfTCnViWTHndzo9606	rigid:rjCxjxJFFB9KyimX1p5LFdsnwXw	false	-	necessary binding region:270-280|sufficient binding region:255-324	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O00303	uniprotkb:P28223-1	intact:EBI-711990|ensembl:ENSP00000431800|ensembl:ENSP00000499218|uniprotkb:Q6IB45|uniprotkb:Q8N978|uniprotkb:A8K0S2	intact:EBI-15573967|ensembl:ENSP00000437737	psi-mi:eif3f_human(display_long)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 5(gene name synonym)|uniprotkb:eIF-3-epsilon(gene name synonym)|uniprotkb:eIF3 p47(gene name synonym)|uniprotkb:EIF3F(gene name)|psi-mi:EIF3F(display_short)|uniprotkb:EIF3S5(gene name synonym)|uniprotkb:Deubiquitinating enzyme eIF3f(gene name synonym)	psi-mi:p28223-1(display_long)|uniprotkb:HTR2A(gene name)|psi-mi:HTR2A(display_short)|uniprotkb:HTR2(gene name synonym)|uniprotkb:Serotonin receptor 2A(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Sheffler et al. (2006)	pubmed:16537434|doi:10.1073/pnas.0600585103|imex:IM-23461	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15574111|imex:IM-23461-8|dip:DIP-197542E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000175390(gene)|ensembl:ENST00000533626(transcript)|ensembl:ENST00000651655(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0075522"(IRES-dependent viral translational initiation)|go:"GO:0101005"(deubiquitinase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR024969|interpro:IPR027531|interpro:IPR037518|mint:O00303|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|refseq:NP_003745.1|dip:DIP-35580N	ensembl:ENSG00000102468(gene)|ensembl:ENST00000542664(transcript)|intact:EBI-6656333(isoform-parent)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/08/04	2017/08/10	rogid:dpH1pTcPshcrSjNCdPPnkYiW0YU9606	rogid:wwxBh+3zPyTL6rfTCnViWTHndzo9606	rigid:lfkRX4NPVzfDIq9ZUIqUsbVY6q8	false	-	sufficient binding region:255-324	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q13232	uniprotkb:P28223-1	intact:EBI-713684|uniprotkb:Q9BWH4|ensembl:ENSP00000219302	intact:EBI-15573967|ensembl:ENSP00000437737	psi-mi:ndk3_human(display_long)|uniprotkb:Nucleoside diphosphate kinase C(gene name synonym)|uniprotkb:nm23-H3(gene name synonym)|uniprotkb:DR-nm23(gene name synonym)|uniprotkb:NME3(gene name)|psi-mi:NME3(display_short)	psi-mi:p28223-1(display_long)|uniprotkb:HTR2A(gene name)|psi-mi:HTR2A(display_short)|uniprotkb:HTR2(gene name synonym)|uniprotkb:Serotonin receptor 2A(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Sheffler et al. (2006)	pubmed:16537434|doi:10.1073/pnas.0600585103|imex:IM-23461	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15574130|imex:IM-23461-9|dip:DIP-197547E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000103024(gene)|ensembl:ENST00000219302(transcript)|go:"GO:0004550"(nucleoside diphosphate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006183"(GTP biosynthetic process)|go:"GO:0006228"(UTP biosynthetic process)|go:"GO:0006241"(CTP biosynthetic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0046872"(metal ion binding)|interpro:IPR001564(Nucleoside diphosphate kinase, core)|interpro:IPR023005|interpro:IPR034907|interpro:IPR036850|mint:Q13232|rcsb pdb:1ZS6|reactome:R-HSA-499943|refseq:NP_002504.2|dip:DIP-49960N	ensembl:ENSG00000102468(gene)|ensembl:ENST00000542664(transcript)|intact:EBI-6656333(isoform-parent)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/08/04	2017/08/10	rogid:/egrHNJSuCILf6NdwwchG9rUGqI9606	rogid:wwxBh+3zPyTL6rfTCnViWTHndzo9606	rigid:Rin52wc43QtZhyE4aisMwJgtcUo	false	-	sufficient binding region:255-324	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P14842	uniprotkb:D3Z8E0	intact:EBI-7090176|ensembl:ENSRNOP00000013408|intact:UNK-5372053	intact:EBI-7624808|intact:MINT-7138988|ensembl:ENSRNOP00000008938	psi-mi:5ht2a_rat(display_long)|uniprotkb:Htr2a(gene name)|psi-mi:Htr2a(display_short)|uniprotkb:Htr2(gene name synonym)|uniprotkb:Serotonin receptor 2A(gene name synonym)	psi-mi:d3z8e0_rat(display_long)|uniprotkb:Rps6ka3(gene name)|psi-mi:Rps6ka3(display_short)|uniprotkb:RGD1563860_predicted(gene name synonym)|uniprotkb:rCG_36295(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sheffler et al. (2006)	pubmed:16537434|doi:10.1073/pnas.0600585103|imex:IM-23461	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15574149|imex:IM-23461-10|dip:DIP-197552E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000010063(gene)|ensembl:ENSRNOT00000013408(transcript)|go:"GO:0001587"(Gq/11-coupled serotonin receptor activity)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007208"(phospholipase C-activating serotonin receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007568"(aging)|go:"GO:0007613"(memory)|go:"GO:0008219"(cell death)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010513"(positive regulation of phosphatidylinositol biosynthetic process)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0014832"(urinary bladder smooth muscle contraction)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030431"(sleep)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043267"(negative regulation of potassium ion transport)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044380"(protein localization to cytoskeleton)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051378"(serotonin binding)|go:"GO:0051967"(negative regulation of synaptic transmission, glutamatergic)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071886"("1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding")|go:"GO:0098664"(G protein-coupled serotonin receptor signaling pathway)|go:"GO:0098666"(G protein-coupled serotonin receptor complex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000455(5-Hydroxytryptamine 2A receptor)|interpro:IPR002231(5-Hydroxytryptamine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P14842|rcsb pdb:4OAJ|reactome:R-RNO-390666|reactome:R-RNO-416476|go:"GO:0070852"(cell body fiber)|refseq:NP_058950.1|rgd:61800|dip:DIP-57661N	rgd:1563860|refseq:NP_001178933.1|ensembl:ENSRNOG00000006632(gene)|ensembl:ENSRNOT00000008938(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0004711"(ribosomal protein S6 kinase activity)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR041905|interpro:IPR041906|mint:D3Z8E0|reactome:R-RNO-198753|reactome:R-RNO-199920|reactome:R-RNO-2559582|reactome:R-RNO-442742|reactome:R-RNO-444257|reactome:R-RNO-881907|interpro:IPR016239(Ribosomal protein S6 kinase II)|dip:DIP-61137N	psi-mi:"MI:0465"(dip)	function:"This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. This receptor is involved in tracheal smooth muscle contraction, bronchoconstriction, and control of aldosterone production"|comment:mint	comment:mint	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	-	2017/08/04	2017/08/10	rogid:CUADU4iCEiVm4kTZ+EZ/w9Omy8M10116	rogid:t0YZN4pU2pS9i5JpbomhTiINDHU10116	rigid:MNGhsOAny6ZiNohyopFY+og/GMM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q16288	uniprotkb:P28223-1	intact:EBI-3936704|uniprotkb:Q16289|uniprotkb:Q12827|uniprotkb:O75682|intact:EBI-28971821|ensembl:ENSP00000354207|ensembl:ENSP00000485864|uniprotkb:B7Z4C5|uniprotkb:E9PG56|uniprotkb:H0YND1	intact:EBI-15573967|ensembl:ENSP00000437737	psi-mi:ntrk3_human(display_long)|uniprotkb:NTRK3(gene name)|psi-mi:NTRK3(display_short)|uniprotkb:TRKC(gene name synonym)|uniprotkb:GP145-TrkC(gene name synonym)|uniprotkb:Neurotrophic tyrosine kinase receptor type 3(gene name synonym)|uniprotkb:TrkC tyrosine kinase(gene name synonym)	psi-mi:p28223-1(display_long)|uniprotkb:HTR2A(gene name)|psi-mi:HTR2A(display_short)|uniprotkb:HTR2(gene name synonym)|uniprotkb:Serotonin receptor 2A(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Sheffler et al. (2006)	pubmed:16537434|doi:10.1073/pnas.0600585103|imex:IM-23461	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15574166|imex:IM-23461-11|dip:DIP-197543E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000317501|ensembl:ENSP00000318328|ensembl:ENST00000355254|ensembl:ENSP00000347397|ensembl:ENST00000357724|ensembl:ENSP00000350356|ensembl:ENSP00000354207|ensembl:ENST00000394480|ensembl:ENSP00000377990|ensembl:ENST00000540489|ensembl:ENSP00000444673|ensembl:ENST00000557856|ensembl:ENSP00000453959|ensembl:ENSP00000485864|refseq:NP_001307063.1|refseq:NP_001307064.1|ensembl:ENSG00000140538(gene)|ensembl:ENST00000360948(transcript)|ensembl:ENST00000629765(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002039"(p53 binding)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005004"(GPI-linked ephrin receptor activity)|go:"GO:0005030"(neurotrophin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0019056"(modulation by virus of host transcription)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0043121"(neurotrophin binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045471"(response to ethanol)|go:"GO:0048665"(neuron fate specification)|go:"GO:0048678"(response to axon injury)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0050927"(positive regulation of positive chemotaxis)|go:"GO:0051412"(response to corticosterone)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0090102"(cochlea development)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099151"(regulation of postsynaptic density assembly)|go:"GO:1905606"(regulation of presynapse assembly)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002011(Receptor tyrosine kinase, class II, conserved site)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020446|interpro:IPR020635|interpro:IPR020777|interpro:IPR031635|interpro:IPR032675|interpro:IPR036179|mint:Q16288|rcsb pdb:1WWC|rcsb pdb:3V5Q|rcsb pdb:4YMJ|rcsb pdb:6KZC|rcsb pdb:6KZD|reactome:R-HSA-388844|reactome:R-HSA-9034013|reactome:R-HSA-9034015|reactome:R-HSA-9034793|reactome:R-HSA-9034864|reactome:R-HSA-9603381|reactome:R-HSA-9603505|refseq:NP_001012338.1|refseq:NP_002521.2|refseq:XP_016877742.1|dip:DIP-5723N	ensembl:ENSG00000102468(gene)|ensembl:ENST00000542664(transcript)|intact:EBI-6656333(isoform-parent)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/08/04	2017/08/10	rogid:PiKp8Av9Q20Xxv00akwE0dazVY09606	rogid:wwxBh+3zPyTL6rfTCnViWTHndzo9606	rigid:+maJLgnJgmzAr698gFAu7AOyDTs	false	-	sufficient binding region:255-324	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O96000	uniprotkb:P28223-1	intact:EBI-1246371|uniprotkb:Q96II6|ensembl:ENSP00000268668	intact:EBI-15573967|ensembl:ENSP00000437737	psi-mi:nduba_human(display_long)|uniprotkb:NDUFB10(gene name)|psi-mi:NDUFB10(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase PDSW subunit(gene name synonym)|uniprotkb:Complex I-PDSW(gene name synonym)	psi-mi:p28223-1(display_long)|uniprotkb:HTR2A(gene name)|psi-mi:HTR2A(display_short)|uniprotkb:HTR2(gene name synonym)|uniprotkb:Serotonin receptor 2A(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Sheffler et al. (2006)	pubmed:16537434|doi:10.1073/pnas.0600585103|imex:IM-23461	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15574204|imex:IM-23461-13|dip:DIP-197548E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004539.1|ensembl:ENSG00000140990(gene)|ensembl:ENST00000268668(transcript)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|interpro:IPR019377|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR039993|rcsb pdb:5XTC|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198|dip:DIP-38298N	ensembl:ENSG00000102468(gene)|ensembl:ENST00000542664(transcript)|intact:EBI-6656333(isoform-parent)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/08/04	2017/08/10	rogid:CRQJLj/I1jZSnIU7GeuRDGN4hRA9606	rogid:wwxBh+3zPyTL6rfTCnViWTHndzo9606	rigid:G7QpkAMOMbrY9M0LVt9xXxytj8o	false	-	sufficient binding region:255-324	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P18654	uniprotkb:P28223-1	intact:EBI-397744|ensembl:ENSMUSP00000033671|uniprotkb:Q03140|uniprotkb:Q8K3J8|uniprotkb:B1AXN4	intact:EBI-15573967|ensembl:ENSP00000437737	psi-mi:ks6a3_mouse(display_long)|uniprotkb:Rps6ka3(gene name)|psi-mi:Rps6ka3(display_short)|uniprotkb:Rps6ka-rs1(gene name synonym)|uniprotkb:Rsk2(gene name synonym)|uniprotkb:90 kDa ribosomal protein S6 kinase 3(gene name synonym)|uniprotkb:Mapkapk1b(gene name synonym)|uniprotkb:Ribosomal S6 kinase 2(gene name synonym)|uniprotkb:pp90RSK2(gene name synonym)|uniprotkb:MAP kinase-activated protein kinase 1b(gene name synonym)	psi-mi:p28223-1(display_long)|uniprotkb:HTR2A(gene name)|psi-mi:HTR2A(display_short)|uniprotkb:HTR2(gene name synonym)|uniprotkb:Serotonin receptor 2A(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sheffler et al. (2006)	pubmed:16537434|doi:10.1073/pnas.0600585103|imex:IM-23461	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15574185|imex:IM-23461-12|dip:DIP-197551E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000031309(gene)|ensembl:ENSMUST00000033671(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004711"(ribosomal protein S6 kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016239(Ribosomal protein S6 kinase II)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR041905|interpro:IPR041906|mint:P18654|rcsb pdb:2QR7|rcsb pdb:2QR8|rcsb pdb:3G51|rcsb pdb:3UBD|rcsb pdb:4EL9|rcsb pdb:4GUE|rcsb pdb:4M8T|rcsb pdb:4MAO|rcsb pdb:5O1S|reactome:R-MMU-198753|reactome:R-MMU-199920|reactome:R-MMU-2559582|reactome:R-MMU-442742|reactome:R-MMU-444257|reactome:R-MMU-881907|refseq:NP_683747.1|dip:DIP-31554N	ensembl:ENSG00000102468(gene)|ensembl:ENST00000542664(transcript)|intact:EBI-6656333(isoform-parent)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/04	2017/08/10	rogid:5h7ZnIO/ZD+MvfouRrhQzWM3Q0010090	rogid:wwxBh+3zPyTL6rfTCnViWTHndzo9606	rigid:rjCxjxJFFB9KyimX1p5LFdsnwXw	false	-	flag tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q13084	uniprotkb:P28223-1	intact:EBI-723426|uniprotkb:Q4TT39|uniprotkb:Q96S26|uniprotkb:Q9BQD8|uniprotkb:Q9BR04|ensembl:ENSP00000199706|ensembl:ENSP00000374326|ensembl:ENSP00000497004|uniprotkb:B2RCM4|uniprotkb:D3DU46	intact:EBI-15573967|ensembl:ENSP00000437737	psi-mi:rm28_human(display_long)|uniprotkb:Melanoma antigen p15(gene name synonym)|uniprotkb:MRPL28(gene name)|psi-mi:MRPL28(display_short)|uniprotkb:MAAT1(gene name synonym)|uniprotkb:Melanoma-associated antigen recognized by T-lymphocytes(gene name synonym)|uniprotkb:Mitochondrial large ribosomal subunit protein bL28m(gene name synonym)	psi-mi:p28223-1(display_long)|uniprotkb:HTR2A(gene name)|psi-mi:HTR2A(display_short)|uniprotkb:HTR2(gene name synonym)|uniprotkb:Serotonin receptor 2A(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Sheffler et al. (2006)	pubmed:16537434|doi:10.1073/pnas.0600585103|imex:IM-23461	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15574223|imex:IM-23461-14|dip:DIP-197544E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006419.2|rcsb pdb:3J7Y|ensembl:ENSG00000086504(gene)|ensembl:ENST00000199706(transcript)|ensembl:ENST00000389675(transcript)|ensembl:ENST00000648346(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005761"(mitochondrial ribosome)|go:"GO:0005762"(mitochondrial large ribosomal subunit)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|interpro:IPR026569|interpro:IPR034704|interpro:IPR037147|mint:Q13084|rcsb pdb:5OOL|rcsb pdb:5OOM|rcsb pdb:6I9R|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5H|rcsb pdb:7A5I|rcsb pdb:7A5J|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7L20|rcsb pdb:7O9K|rcsb pdb:7O9M|rcsb pdb:7ODR|rcsb pdb:7ODS|rcsb pdb:7ODT|rcsb pdb:7OF0|rcsb pdb:7OF2|rcsb pdb:7OF3|rcsb pdb:7OF4|rcsb pdb:7OF5|rcsb pdb:7OF6|rcsb pdb:7OF7|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|refseq:XP_011520653.1|refseq:XP_005255098.1|dip:DIP-61135N	ensembl:ENSG00000102468(gene)|ensembl:ENST00000542664(transcript)|intact:EBI-6656333(isoform-parent)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/08/04	2017/08/10	rogid:rgjK24sQlABM210ZM7T9mT2wxKs9606	rogid:wwxBh+3zPyTL6rfTCnViWTHndzo9606	rigid:kb5gfnalw07Vuw34VBskURv2r9c	false	-	sufficient binding region:255-324	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)