#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q24139	uniprotkb:Q9VVI3	intact:EBI-118294|uniprotkb:Q9VUT9|ensemblmetazoa:FBpp0075332|ensemblmetazoa:FBpp0305237	intact:EBI-498113|uniprotkb:Q7KUR2|uniprotkb:Q8IQR6|uniprotkb:Q95R64|uniprotkb:Q95TQ0|uniprotkb:Q95ZF9|ensemblmetazoa:FBpp0289746	psi-mi:comm_drome(display_long)|uniprotkb:comm(gene name)|psi-mi:comm(display_short)|uniprotkb:Protein commissureless(gene name synonym)|uniprotkb:CG17943(orf name)	psi-mi:nedd4_drome(display_long)|uniprotkb:HECT-type E3 ubiquitin transferase NEDD4(gene name synonym)|uniprotkb:CG7555(orf name)|uniprotkb:Nedd4(gene name)|psi-mi:Nedd4(display_short)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Kanelis et al. (2006)	pubmed:16531238|doi:10.1016/j.str.2005.11.018|imex:IM-8342	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15573467|imex:IM-8342-2|dip:DIP-57041E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_524095.1|flybase:FBgn0010105|refseq:NP_001261891.1|ensemblmetazoa:FBgn0010105(gene)|ensemblmetazoa:FBtr0075579(transcript)|ensemblmetazoa:FBtr0333023(transcript)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0007399"(nervous system development)|go:"GO:0007411"(axon guidance)|go:"GO:0007416"(synapse assembly)|go:"GO:0031902"(late endosome membrane)|go:"GO:0008038"(neuron recognition)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016199"(axon midline choice point recognition)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031982"(vesicle)|go:"GO:0048495"(Roundabout binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050699"(WW domain binding)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0070983"(dendrite guidance)|go:"GO:0090160"(Golgi to lysosome transport)|interpro:IPR031878|rcsb pdb:2EZ5|dip:DIP-22799N	refseq:NP_648993.1|refseq:NP_730282.1|refseq:NP_730283.1|refseq:NP_996116.1|flybase:FBgn0259174|dip:DIP-29040N|ensemblmetazoa:FBgn0259174(gene)|ensemblmetazoa:FBtr0300519(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005112"(Notch binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008586"(imaginal disc-derived wing vein morphogenesis)|go:"GO:0016199"(axon midline choice point recognition)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017022"(myosin binding)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031623"(receptor internalization)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0071212"(subsynaptic reticulum)|go:"GO:1905062"(positive regulation of cardioblast proliferation)|go:"GO:1905306"(positive regulation of cardiac myofibril assembly)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|rcsb pdb:2EZ5|reactome:R-DME-1253288|reactome:R-DME-2173795|reactome:R-DME-8948747|reactome:R-DME-8948751|reactome:R-DME-983168	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/04	2017/08/10	rogid:XWYmHZwsV9lU9rT5zWoPgzkiOiQ7227	rogid:IIVKUUEjopMfaBBOZWdwdYAUWpQ7227	rigid:CWJnmhgQ/tOj6Flwg7TMOYqik9o	false	sufficient binding region:227-237	sufficient binding region:526-566|13c label:n-n|15n label:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q24139	uniprotkb:Q9VVI3	intact:EBI-118294|uniprotkb:Q9VUT9|ensemblmetazoa:FBpp0075332|ensemblmetazoa:FBpp0305237	intact:EBI-498113|uniprotkb:Q7KUR2|uniprotkb:Q8IQR6|uniprotkb:Q95R64|uniprotkb:Q95TQ0|uniprotkb:Q95ZF9|ensemblmetazoa:FBpp0289746	psi-mi:comm_drome(display_long)|uniprotkb:comm(gene name)|psi-mi:comm(display_short)|uniprotkb:Protein commissureless(gene name synonym)|uniprotkb:CG17943(orf name)	psi-mi:nedd4_drome(display_long)|uniprotkb:HECT-type E3 ubiquitin transferase NEDD4(gene name synonym)|uniprotkb:CG7555(orf name)|uniprotkb:Nedd4(gene name)|psi-mi:Nedd4(display_short)	psi-mi:"MI:0051"(fluorescence technology)	Kanelis et al. (2006)	pubmed:16531238|doi:10.1016/j.str.2005.11.018|imex:IM-8342	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15573492|imex:IM-8342-3|dip:DIP-57041E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_524095.1|flybase:FBgn0010105|refseq:NP_001261891.1|ensemblmetazoa:FBgn0010105(gene)|ensemblmetazoa:FBtr0075579(transcript)|ensemblmetazoa:FBtr0333023(transcript)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0007399"(nervous system development)|go:"GO:0007411"(axon guidance)|go:"GO:0007416"(synapse assembly)|go:"GO:0031902"(late endosome membrane)|go:"GO:0008038"(neuron recognition)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016199"(axon midline choice point recognition)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031982"(vesicle)|go:"GO:0048495"(Roundabout binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050699"(WW domain binding)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0070983"(dendrite guidance)|go:"GO:0090160"(Golgi to lysosome transport)|interpro:IPR031878|rcsb pdb:2EZ5|dip:DIP-22799N	refseq:NP_648993.1|refseq:NP_730282.1|refseq:NP_730283.1|refseq:NP_996116.1|flybase:FBgn0259174|dip:DIP-29040N|ensemblmetazoa:FBgn0259174(gene)|ensemblmetazoa:FBtr0300519(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005112"(Notch binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008586"(imaginal disc-derived wing vein morphogenesis)|go:"GO:0016199"(axon midline choice point recognition)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017022"(myosin binding)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031623"(receptor internalization)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0071212"(subsynaptic reticulum)|go:"GO:1905062"(positive regulation of cardioblast proliferation)|go:"GO:1905306"(positive regulation of cardiac myofibril assembly)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|rcsb pdb:2EZ5|reactome:R-DME-1253288|reactome:R-DME-2173795|reactome:R-DME-8948747|reactome:R-DME-8948751|reactome:R-DME-983168	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/04	2017/08/10	rogid:XWYmHZwsV9lU9rT5zWoPgzkiOiQ7227	rogid:IIVKUUEjopMfaBBOZWdwdYAUWpQ7227	rigid:CWJnmhgQ/tOj6Flwg7TMOYqik9o	false	sufficient binding region:227-237	sufficient binding region:527-571	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q24139	uniprotkb:Q9VVI3	intact:EBI-118294|uniprotkb:Q9VUT9|ensemblmetazoa:FBpp0075332|ensemblmetazoa:FBpp0305237	intact:EBI-498113|uniprotkb:Q7KUR2|uniprotkb:Q8IQR6|uniprotkb:Q95R64|uniprotkb:Q95TQ0|uniprotkb:Q95ZF9|ensemblmetazoa:FBpp0289746	psi-mi:comm_drome(display_long)|uniprotkb:comm(gene name)|psi-mi:comm(display_short)|uniprotkb:Protein commissureless(gene name synonym)|uniprotkb:CG17943(orf name)	psi-mi:nedd4_drome(display_long)|uniprotkb:HECT-type E3 ubiquitin transferase NEDD4(gene name synonym)|uniprotkb:CG7555(orf name)|uniprotkb:Nedd4(gene name)|psi-mi:Nedd4(display_short)	psi-mi:"MI:0051"(fluorescence technology)	Kanelis et al. (2006)	pubmed:16531238|doi:10.1016/j.str.2005.11.018|imex:IM-8342	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15573513|imex:IM-8342-1|dip:DIP-57041E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_524095.1|flybase:FBgn0010105|refseq:NP_001261891.1|ensemblmetazoa:FBgn0010105(gene)|ensemblmetazoa:FBtr0075579(transcript)|ensemblmetazoa:FBtr0333023(transcript)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0007399"(nervous system development)|go:"GO:0007411"(axon guidance)|go:"GO:0007416"(synapse assembly)|go:"GO:0031902"(late endosome membrane)|go:"GO:0008038"(neuron recognition)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016199"(axon midline choice point recognition)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031982"(vesicle)|go:"GO:0048495"(Roundabout binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050699"(WW domain binding)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0070983"(dendrite guidance)|go:"GO:0090160"(Golgi to lysosome transport)|interpro:IPR031878|rcsb pdb:2EZ5|dip:DIP-22799N	refseq:NP_648993.1|refseq:NP_730282.1|refseq:NP_730283.1|refseq:NP_996116.1|flybase:FBgn0259174|dip:DIP-29040N|ensemblmetazoa:FBgn0259174(gene)|ensemblmetazoa:FBtr0300519(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005112"(Notch binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008586"(imaginal disc-derived wing vein morphogenesis)|go:"GO:0016199"(axon midline choice point recognition)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017022"(myosin binding)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031623"(receptor internalization)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0071212"(subsynaptic reticulum)|go:"GO:1905062"(positive regulation of cardioblast proliferation)|go:"GO:1905306"(positive regulation of cardiac myofibril assembly)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|rcsb pdb:2EZ5|reactome:R-DME-1253288|reactome:R-DME-2173795|reactome:R-DME-8948747|reactome:R-DME-8948751|reactome:R-DME-983168	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/04	2017/08/10	rogid:XWYmHZwsV9lU9rT5zWoPgzkiOiQ7227	rogid:IIVKUUEjopMfaBBOZWdwdYAUWpQ7227	rigid:CWJnmhgQ/tOj6Flwg7TMOYqik9o	false	sufficient binding region:227-237	sufficient binding region:577-612	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)