#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O08530	uniprotkb:P37217	intact:EBI-771204|uniprotkb:Q9DC35|uniprotkb:Q9R235|ensembl:ENSMUSP00000050897	intact:EBI-15573048|ensembl:ENSMUSP00000032259	psi-mi:s1pr1_mouse(display_long)|uniprotkb:Edg1(gene name synonym)|uniprotkb:Sphingosine 1-phosphate receptor Edg-1(gene name synonym)|uniprotkb:Endothelial differentiation G-protein coupled receptor 1(gene name synonym)|uniprotkb:Lysophospholipid receptor B1(gene name synonym)|uniprotkb:S1pr1(gene name)|psi-mi:S1pr1(display_short)|uniprotkb:Lpb1(gene name synonym)	psi-mi:cd69_mouse(display_long)|uniprotkb:Cd69(gene name)|psi-mi:Cd69(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shiow et al. (2006)	pubmed:16525420|doi:10.1038/nature04606|imex:IM-21463	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15573069|imex:IM-21463-1|dip:DIP-191623E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031927.2|dip:DIP-32248N|ensembl:ENSMUSG00000045092(gene)|ensembl:ENSMUST00000055676(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001955"(blood vessel maturation)|go:"GO:0003245"(cardiac muscle tissue growth involved in heart morphogenesis)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006935"(chemotaxis)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019226"(transmission of nerve impulse)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030500"(regulation of bone mineralization)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0038036"(sphingosine-1-phosphate receptor activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:0045446"(endothelial cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050927"(positive regulation of positive chemotaxis)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0061384"(heart trabecula morphogenesis)|go:"GO:0072678"(T cell migration)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000987(EDG-1 sphingosine 1-phosphate receptor)|interpro:IPR004061(Sphingosine 1-phosphate receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-MMU-419408	ensembl:ENSMUSG00000030156(gene)|ensembl:ENSMUST00000032259(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035690"|go:"GO:0042802"(identical protein binding)|interpro:IPR001304(C-type lectin)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR033992|refseq:NP_001028294.1|dip:DIP-60425N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/04	2017/08/10	rogid:EptiCvg7t3clTAKGgiGRmg6cZeY10090	rogid:NiwwqjO1qhpQNbvZB8M2cQ5JURY10090	rigid:OlJYV6BWS3VAg9IyLEUzb7NiNoQ	false	flag tag:n-n	ha tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P21453	uniprotkb:Q07108	intact:EBI-2681920|uniprotkb:Q9BYY4|uniprotkb:Q9NYN8|uniprotkb:D3DT66|ensembl:ENSP00000305416|ensembl:ENSP00000497175|ensembl:ENSP00000497478|ensembl:ENSP00000498038	intact:EBI-2836595|ensembl:ENSP00000228434	psi-mi:s1pr1_human(display_long)|uniprotkb:S1PR1(gene name)|psi-mi:S1PR1(display_short)|uniprotkb:CHEDG1(gene name synonym)|uniprotkb:EDG1(gene name synonym)|uniprotkb:Endothelial differentiation G-protein coupled receptor 1(gene name synonym)|uniprotkb:Sphingosine 1-phosphate receptor Edg-1(gene name synonym)	psi-mi:cd69_human(display_long)|uniprotkb:CD69(gene name)|psi-mi:CD69(display_short)|uniprotkb:CLEC2C(gene name synonym)|uniprotkb:Activation inducer molecule(gene name synonym)|uniprotkb:BL-AC/P26(gene name synonym)|uniprotkb:C-type lectin domain family 2 member C(gene name synonym)|uniprotkb:EA1(gene name synonym)|uniprotkb:Early T-cell activation antigen p60(gene name synonym)|uniprotkb:GP32/28(gene name synonym)|uniprotkb:Leukocyte surface antigen Leu-23(gene name synonym)|uniprotkb:MLR-3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Shiow et al. (2006)	pubmed:16525420|doi:10.1038/nature04606|imex:IM-21463	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15573090|imex:IM-21463-2|dip:DIP-191624E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001307659.1|refseq:NP_001391.2|go:"GO:0045124"(regulation of bone resorption)|go:"GO:0045446"(endothelial cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050927"(positive regulation of positive chemotaxis)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0061384"(heart trabecula morphogenesis)|go:"GO:0072678"(T cell migration)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000987(EDG-1 sphingosine 1-phosphate receptor)|interpro:IPR004061(Sphingosine 1-phosphate receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:3V2W|rcsb pdb:3V2Y|reactome:R-HSA-419408|reactome:R-HSA-6785807|ensembl:ENSG00000170989(gene)|ensembl:ENST00000305352(transcript)|ensembl:ENST00000475289(transcript)|ensembl:ENST00000648480(transcript)|ensembl:ENST00000649383(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001955"(blood vessel maturation)|go:"GO:0003245"(cardiac muscle tissue growth involved in heart morphogenesis)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0007155"(cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019226"(transmission of nerve impulse)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030500"(regulation of bone mineralization)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0038036"(sphingosine-1-phosphate receptor activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045121"(membrane raft)|reactome:R-HSA-9679191|dip:DIP-60427N	refseq:NP_001772.1|ensembl:ENSG00000110848(gene)|ensembl:ENST00000228434(transcript)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|interpro:IPR001304(C-type lectin)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR033992|rcsb pdb:1E87|rcsb pdb:1E8I|rcsb pdb:1FM5|rcsb pdb:3CCK|rcsb pdb:3HUP|dip:DIP-60426N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/04	2017/08/10	rogid:LVtMWT8CaCKezjGOwXuQugL/8NA9606	rogid:6vbLl7xRESvTIqEL55C0ojlQJ5A9606	rigid:AXnqknvdaJNeN2uUVZHApUUCoEM	false	myc tag:c-c	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P21453	uniprotkb:Q07108	intact:EBI-2681920|uniprotkb:Q9BYY4|uniprotkb:Q9NYN8|uniprotkb:D3DT66|ensembl:ENSP00000305416|ensembl:ENSP00000497175|ensembl:ENSP00000497478|ensembl:ENSP00000498038	intact:EBI-2836595|ensembl:ENSP00000228434	psi-mi:s1pr1_human(display_long)|uniprotkb:S1PR1(gene name)|psi-mi:S1PR1(display_short)|uniprotkb:CHEDG1(gene name synonym)|uniprotkb:EDG1(gene name synonym)|uniprotkb:Endothelial differentiation G-protein coupled receptor 1(gene name synonym)|uniprotkb:Sphingosine 1-phosphate receptor Edg-1(gene name synonym)	psi-mi:cd69_human(display_long)|uniprotkb:CD69(gene name)|psi-mi:CD69(display_short)|uniprotkb:CLEC2C(gene name synonym)|uniprotkb:Activation inducer molecule(gene name synonym)|uniprotkb:BL-AC/P26(gene name synonym)|uniprotkb:C-type lectin domain family 2 member C(gene name synonym)|uniprotkb:EA1(gene name synonym)|uniprotkb:Early T-cell activation antigen p60(gene name synonym)|uniprotkb:GP32/28(gene name synonym)|uniprotkb:Leukocyte surface antigen Leu-23(gene name synonym)|uniprotkb:MLR-3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shiow et al. (2006)	pubmed:16525420|doi:10.1038/nature04606|imex:IM-21463	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15573109|imex:IM-21463-3|dip:DIP-191624E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001307659.1|refseq:NP_001391.2|go:"GO:0045124"(regulation of bone resorption)|go:"GO:0045446"(endothelial cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050927"(positive regulation of positive chemotaxis)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0061384"(heart trabecula morphogenesis)|go:"GO:0072678"(T cell migration)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000987(EDG-1 sphingosine 1-phosphate receptor)|interpro:IPR004061(Sphingosine 1-phosphate receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:3V2W|rcsb pdb:3V2Y|reactome:R-HSA-419408|reactome:R-HSA-6785807|ensembl:ENSG00000170989(gene)|ensembl:ENST00000305352(transcript)|ensembl:ENST00000475289(transcript)|ensembl:ENST00000648480(transcript)|ensembl:ENST00000649383(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001955"(blood vessel maturation)|go:"GO:0003245"(cardiac muscle tissue growth involved in heart morphogenesis)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0007155"(cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019226"(transmission of nerve impulse)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030500"(regulation of bone mineralization)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0038036"(sphingosine-1-phosphate receptor activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045121"(membrane raft)|reactome:R-HSA-9679191|dip:DIP-60427N	refseq:NP_001772.1|ensembl:ENSG00000110848(gene)|ensembl:ENST00000228434(transcript)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|interpro:IPR001304(C-type lectin)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR033992|rcsb pdb:1E87|rcsb pdb:1E8I|rcsb pdb:1FM5|rcsb pdb:3CCK|rcsb pdb:3HUP|dip:DIP-60426N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/04	2017/08/10	rogid:LVtMWT8CaCKezjGOwXuQugL/8NA9606	rogid:6vbLl7xRESvTIqEL55C0ojlQJ5A9606	rigid:AXnqknvdaJNeN2uUVZHApUUCoEM	false	myc tag:c-c	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)