#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q8R4I1 uniprotkb:Q8VE65 intact:EBI-7990748|uniprotkb:E9QPX9|intact:UNK-5525593|uniprotkb:Q8BL17|ensembl:ENSMUSP00000022257|ensembl:ENSMUSP00000152934 intact:EBI-7990784|intact:MINT-4136826|uniprotkb:Q9D8Q0|uniprotkb:Q3V0S7|uniprotkb:Q9CZ11|ensembl:ENSMUSP00000030731 psi-mi:atx7_mouse(display_long)|uniprotkb:Atxn7(gene name)|psi-mi:Atxn7(display_short)|uniprotkb:Sca7(gene name synonym)|uniprotkb:Spinocerebellar ataxia type 7 protein homolog(gene name synonym) psi-mi:taf12_mouse(display_long)|uniprotkb:Taf12(gene name)|psi-mi:Taf12(display_short)|uniprotkb:Transcription initiation factor TFIID 20 kDa subunits(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Helmlinger et al. (2006) pubmed:16494529|doi:10.1371/journal.pbio.0040067|imex:IM-8500 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15571704|imex:IM-8500-4|dip:DIP-57185E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-29176N|refseq:NP_631973.3|ensembl:ENSMUSG00000021738(gene)|ensembl:ENSMUST00000022257(transcript)|ensembl:ENSMUST00000223880(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0043569"(negative regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR013243(SCA7)|interpro:IPR030706|reactome:R-MMU-5689880 refseq:XP_017175839.1|dip:DIP-29178N|refseq:NP_079855.2|refseq:XP_006539172.1|refseq:XP_006539173.1|refseq:XP_006539170.2|ensembl:ENSMUSG00000028899(gene)|ensembl:ENSMUST00000030731(transcript)|go:"GO:0000124"(SAGA complex)|go:"GO:0000125"|go:"GO:0003677"(DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005669"(transcription factor TFIID complex)|go:"GO:0006352"(DNA-templated transcription, initiation)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0030914"|go:"GO:0033276"(transcription factor TFTC complex)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0046695"("SLIK (SAGA-like) complex")|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051123"(RNA polymerase II preinitiation complex assembly)|interpro:IPR003228(Transcription initiation factor TFIID)|interpro:IPR009072(Histone-fold)|interpro:IPR037794|mint:Q8VE65|reactome:R-MMU-674695|reactome:R-MMU-6804756|reactome:R-MMU-73776|reactome:R-MMU-73779|reactome:R-MMU-75953|reactome:R-MMU-76042 psi-mi:"MI:0465"(dip) function:Involved in neurodegeneration. Acts as component of the STAGA transcription coactivator-HAT complex. Mediates the interaction of STAGA complex with the CRX and is involved in CRX-dependent gene activation|comment:mint comment:mint|function:"TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TAFs components-TIIFD are essential for mediating regulation of RNA polymerase transcription" full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse)|taxid:10090(Mus musculus) - 2017/08/04 2017/08/10 rogid:QxhOtTIxpgF6pvAfVwWQ//A6SY810090 rogid:5G+IyLHK+TK5l4RTTFIPh8B650g10090 rigid:+/1Y9fttCr8OOCOdWvq8AiTIsdk false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8R4I1 uniprotkb:Q9JHD2 intact:EBI-7990748|uniprotkb:E9QPX9|intact:UNK-5525593|uniprotkb:Q8BL17|ensembl:ENSMUSP00000022257|ensembl:ENSMUSP00000152934 intact:EBI-2943116|uniprotkb:Q3TZ59|ensembl:ENSMUSP00000099407 psi-mi:atx7_mouse(display_long)|uniprotkb:Atxn7(gene name)|psi-mi:Atxn7(display_short)|uniprotkb:Sca7(gene name synonym)|uniprotkb:Spinocerebellar ataxia type 7 protein homolog(gene name synonym) psi-mi:kat2a_mouse(display_long)|uniprotkb:Kat2a(gene name)|psi-mi:Kat2a(display_short)|uniprotkb:Gcn5l2(gene name synonym)|uniprotkb:General control of amino acid synthesis protein 5-like 2(gene name synonym)|uniprotkb:Histone acetyltransferase GCN5(gene name synonym)|uniprotkb:Lysine acetyltransferase 2A(gene name synonym)|uniprotkb:Histone succinyltransferase KAT2A(gene name synonym)|uniprotkb:Histone glutaryltransferase KAT2A(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Helmlinger et al. (2006) pubmed:16494529|doi:10.1371/journal.pbio.0040067|imex:IM-8500 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15571704|imex:IM-8500-4|dip:DIP-57185E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-29176N|refseq:NP_631973.3|ensembl:ENSMUSG00000021738(gene)|ensembl:ENSMUST00000022257(transcript)|ensembl:ENSMUST00000223880(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0043569"(negative regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR013243(SCA7)|interpro:IPR030706|reactome:R-MMU-5689880 ensembl:ENSMUSG00000020918(gene)|ensembl:ENSMUST00000103118(transcript)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0000785"(chromatin)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001756"(somitogenesis)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001843"(neural tube closure)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005671"(obsolete Ada2/Gcn5/Ada3 transcription activator complex)|go:"GO:0005813"(centrosome)|go:"GO:0007507"(heart development)|go:"GO:0007616"(long-term memory)|go:"GO:0008080"(N-acetyltransferase activity)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010484"(H3 histone acetyltransferase activity)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016407"(acetyltransferase activity)|go:"GO:0016573"(histone acetylation)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0018393"(internal peptidyl-lysine acetylation)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0007399"(nervous system development)|go:"GO:0021537"(telencephalon development)|go:"GO:0022037"(metencephalon development)|go:"GO:0030901"(midbrain development)|go:"GO:0030914"|go:"GO:0031346"(positive regulation of cell projection organization)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0033276"(transcription factor TFTC complex)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043983"(histone H4-K12 acetylation)|go:"GO:0043997"("histone acetyltransferase activity (H4-K12 specific)")|go:"GO:0044154"(histone H3-K14 acetylation)|go:"GO:0045252"(oxoglutarate dehydrogenase complex)|go:"GO:0045589"(regulation of regulatory T cell differentiation)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046600"(negative regulation of centriole replication)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0060173"(limb development)|go:"GO:0061035"(regulation of cartilage development)|go:"GO:0061733"(peptide-lysine-N-acetyltransferase activity)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071929"(alpha-tubulin acetylation)|go:"GO:0072686"(mitotic spindle)|go:"GO:0106077"(histone succinylation)|go:"GO:0106078"(histone succinyltransferase activity)|go:"GO:0106227"(peptidyl-lysine glutarylation)|go:"GO:0106229"(histone glutaryltransferase activity)|go:"GO:1903010"(regulation of bone development)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000036"(regulation of stem cell population maintenance)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|interpro:IPR000182(GCN5-related N-acetyltransferase)|interpro:IPR001487(Bromodomain)|interpro:IPR009464(PCAF, N-terminal)|interpro:IPR016181(Acyl-CoA N-acyltransferase)|interpro:IPR016376(Histone acetylase PCAF)|interpro:IPR018359|interpro:IPR036427|interpro:IPR037800|mint:Q9JHD2|rcsb pdb:7BY1|reactome:R-MMU-2122947|reactome:R-MMU-350054|reactome:R-MMU-5250924|reactome:R-MMU-8941856|reactome:R-MMU-5689880|refseq:NP_064388.2|dip:DIP-29180N psi-mi:"MI:0465"(dip) function:Involved in neurodegeneration. Acts as component of the STAGA transcription coactivator-HAT complex. Mediates the interaction of STAGA complex with the CRX and is involved in CRX-dependent gene activation|comment:mint - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse)|taxid:10090(Mus musculus) - 2017/08/04 2017/08/10 rogid:QxhOtTIxpgF6pvAfVwWQ//A6SY810090 rogid:hBMAmuZMuoxU1uoqaeHLoSbPies10090 rigid:+/1Y9fttCr8OOCOdWvq8AiTIsdk false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8R4I1 uniprotkb:Q80YV3 intact:EBI-7990748|uniprotkb:E9QPX9|intact:UNK-5525593|uniprotkb:Q8BL17|ensembl:ENSMUSP00000022257|ensembl:ENSMUSP00000152934 intact:EBI-2942477|uniprotkb:Q8C0Z5|uniprotkb:Q8K104 psi-mi:atx7_mouse(display_long)|uniprotkb:Atxn7(gene name)|psi-mi:Atxn7(display_short)|uniprotkb:Sca7(gene name synonym)|uniprotkb:Spinocerebellar ataxia type 7 protein homolog(gene name synonym) psi-mi:trrap_mouse(display_long)|uniprotkb:Trrap(gene name)|psi-mi:Trrap(display_short)|uniprotkb:Tra1 homolog(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Helmlinger et al. (2006) pubmed:16494529|doi:10.1371/journal.pbio.0040067|imex:IM-8500 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15571704|imex:IM-8500-4|dip:DIP-57185E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-29176N|refseq:NP_631973.3|ensembl:ENSMUSG00000021738(gene)|ensembl:ENSMUST00000022257(transcript)|ensembl:ENSMUST00000223880(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0043569"(negative regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR013243(SCA7)|interpro:IPR030706|reactome:R-MMU-5689880 go:"GO:0043967"(histone H4 acetylation)|go:"GO:0043968"(histone H2A acetylation)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR033317|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0030914"|go:"GO:0033276"(transcription factor TFTC complex)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0000124"(SAGA complex)|go:"GO:0000812"(Swr1 complex)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006281"(DNA repair)|dip:DIP-29177N|mint:Q80YV3 psi-mi:"MI:0465"(dip) function:Involved in neurodegeneration. Acts as component of the STAGA transcription coactivator-HAT complex. Mediates the interaction of STAGA complex with the CRX and is involved in CRX-dependent gene activation|comment:mint - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse)|taxid:10090(Mus musculus) - 2017/08/04 2017/08/10 rogid:QxhOtTIxpgF6pvAfVwWQ//A6SY810090 rogid:gB6vJ5mDsz4UFIbdOcUgzOlsqV810090 rigid:+/1Y9fttCr8OOCOdWvq8AiTIsdk false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9JHD2 uniprotkb:Q80YV3 intact:EBI-2943116|uniprotkb:Q3TZ59|ensembl:ENSMUSP00000099407 intact:EBI-2942477|uniprotkb:Q8C0Z5|uniprotkb:Q8K104 psi-mi:kat2a_mouse(display_long)|uniprotkb:Kat2a(gene name)|psi-mi:Kat2a(display_short)|uniprotkb:Gcn5l2(gene name synonym)|uniprotkb:General control of amino acid synthesis protein 5-like 2(gene name synonym)|uniprotkb:Histone acetyltransferase GCN5(gene name synonym)|uniprotkb:Lysine acetyltransferase 2A(gene name synonym)|uniprotkb:Histone succinyltransferase KAT2A(gene name synonym)|uniprotkb:Histone glutaryltransferase KAT2A(gene name synonym) psi-mi:trrap_mouse(display_long)|uniprotkb:Trrap(gene name)|psi-mi:Trrap(display_short)|uniprotkb:Tra1 homolog(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Helmlinger et al. (2006) pubmed:16494529|doi:10.1371/journal.pbio.0040067|imex:IM-8500 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15571740|imex:IM-8500-1|dip:DIP-57187E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000020918(gene)|ensembl:ENSMUST00000103118(transcript)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0000785"(chromatin)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001756"(somitogenesis)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001843"(neural tube closure)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005671"(obsolete Ada2/Gcn5/Ada3 transcription activator complex)|go:"GO:0005813"(centrosome)|go:"GO:0007507"(heart development)|go:"GO:0007616"(long-term memory)|go:"GO:0008080"(N-acetyltransferase activity)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010484"(H3 histone acetyltransferase activity)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016407"(acetyltransferase activity)|go:"GO:0016573"(histone acetylation)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0018393"(internal peptidyl-lysine acetylation)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0007399"(nervous system development)|go:"GO:0021537"(telencephalon development)|go:"GO:0022037"(metencephalon development)|go:"GO:0030901"(midbrain development)|go:"GO:0030914"|go:"GO:0031346"(positive regulation of cell projection organization)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0033276"(transcription factor TFTC complex)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043983"(histone H4-K12 acetylation)|go:"GO:0043997"("histone acetyltransferase activity (H4-K12 specific)")|go:"GO:0044154"(histone H3-K14 acetylation)|go:"GO:0045252"(oxoglutarate dehydrogenase complex)|go:"GO:0045589"(regulation of regulatory T cell differentiation)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046600"(negative regulation of centriole replication)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0060173"(limb development)|go:"GO:0061035"(regulation of cartilage development)|go:"GO:0061733"(peptide-lysine-N-acetyltransferase activity)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071929"(alpha-tubulin acetylation)|go:"GO:0072686"(mitotic spindle)|go:"GO:0106077"(histone succinylation)|go:"GO:0106078"(histone succinyltransferase activity)|go:"GO:0106227"(peptidyl-lysine glutarylation)|go:"GO:0106229"(histone glutaryltransferase activity)|go:"GO:1903010"(regulation of bone development)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000036"(regulation of stem cell population maintenance)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|interpro:IPR000182(GCN5-related N-acetyltransferase)|interpro:IPR001487(Bromodomain)|interpro:IPR009464(PCAF, N-terminal)|interpro:IPR016181(Acyl-CoA N-acyltransferase)|interpro:IPR016376(Histone acetylase PCAF)|interpro:IPR018359|interpro:IPR036427|interpro:IPR037800|mint:Q9JHD2|rcsb pdb:7BY1|reactome:R-MMU-2122947|reactome:R-MMU-350054|reactome:R-MMU-5250924|reactome:R-MMU-8941856|reactome:R-MMU-5689880|refseq:NP_064388.2|dip:DIP-29180N go:"GO:0043967"(histone H4 acetylation)|go:"GO:0043968"(histone H2A acetylation)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR033317|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0030914"|go:"GO:0033276"(transcription factor TFTC complex)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0000124"(SAGA complex)|go:"GO:0000812"(Swr1 complex)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006281"(DNA repair)|dip:DIP-29177N|mint:Q80YV3 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse)|taxid:10090(Mus musculus) - 2017/08/04 2017/08/10 rogid:hBMAmuZMuoxU1uoqaeHLoSbPies10090 rogid:gB6vJ5mDsz4UFIbdOcUgzOlsqV810090 rigid:SrkPuweG9mFHdJ2fIkVYbTQfwzk false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8R4I1 uniprotkb:Q80YV3 intact:EBI-7990748|uniprotkb:E9QPX9|intact:UNK-5525593|uniprotkb:Q8BL17|ensembl:ENSMUSP00000022257|ensembl:ENSMUSP00000152934 intact:EBI-2942477|uniprotkb:Q8C0Z5|uniprotkb:Q8K104 psi-mi:atx7_mouse(display_long)|uniprotkb:Atxn7(gene name)|psi-mi:Atxn7(display_short)|uniprotkb:Sca7(gene name synonym)|uniprotkb:Spinocerebellar ataxia type 7 protein homolog(gene name synonym) psi-mi:trrap_mouse(display_long)|uniprotkb:Trrap(gene name)|psi-mi:Trrap(display_short)|uniprotkb:Tra1 homolog(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Helmlinger et al. (2006) pubmed:16494529|doi:10.1371/journal.pbio.0040067|imex:IM-8500 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15571723|imex:IM-8500-2|dip:DIP-57186E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-29176N|refseq:NP_631973.3|ensembl:ENSMUSG00000021738(gene)|ensembl:ENSMUST00000022257(transcript)|ensembl:ENSMUST00000223880(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0043569"(negative regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR013243(SCA7)|interpro:IPR030706|reactome:R-MMU-5689880 go:"GO:0043967"(histone H4 acetylation)|go:"GO:0043968"(histone H2A acetylation)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR033317|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0030914"|go:"GO:0033276"(transcription factor TFTC complex)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0000124"(SAGA complex)|go:"GO:0000812"(Swr1 complex)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006281"(DNA repair)|dip:DIP-29177N|mint:Q80YV3 psi-mi:"MI:0465"(dip) function:Involved in neurodegeneration. Acts as component of the STAGA transcription coactivator-HAT complex. Mediates the interaction of STAGA complex with the CRX and is involved in CRX-dependent gene activation|comment:mint - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse)|taxid:10090(Mus musculus) - 2017/08/04 2017/08/10 rogid:QxhOtTIxpgF6pvAfVwWQ//A6SY810090 rogid:gB6vJ5mDsz4UFIbdOcUgzOlsqV810090 rigid:Zp3oU/iH5QthEMgXqmgzAUnksNg false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8R4I1 uniprotkb:Q8BU36 intact:EBI-7990748|uniprotkb:E9QPX9|intact:UNK-5525593|uniprotkb:Q8BL17|ensembl:ENSMUSP00000022257|ensembl:ENSMUSP00000152934 intact:EBI-2943300 psi-mi:atx7_mouse(display_long)|uniprotkb:Atxn7(gene name)|psi-mi:Atxn7(display_short)|uniprotkb:Sca7(gene name synonym)|uniprotkb:Spinocerebellar ataxia type 7 protein homolog(gene name synonym) psi-mi:q8bu36_mouse(display_long)|uniprotkb:Supt3(gene name)|psi-mi:Supt3(display_short)|uniprotkb:Supt3h(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Helmlinger et al. (2006) pubmed:16494529|doi:10.1371/journal.pbio.0040067|imex:IM-8500 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15571757|imex:IM-8500-3|dip:DIP-57188E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-29176N|refseq:NP_631973.3|ensembl:ENSMUSG00000021738(gene)|ensembl:ENSMUST00000022257(transcript)|ensembl:ENSMUST00000223880(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0043569"(negative regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR013243(SCA7)|interpro:IPR030706|reactome:R-MMU-5689880 go:"GO:0043966"(histone H3 acetylation)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR003195(Transcription initiation factor IID, 18 kDa subunit)|interpro:IPR009072(Histone-fold)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0030914"|go:"GO:0033276"(transcription factor TFTC complex)|dip:DIP-29179N psi-mi:"MI:0465"(dip) function:Involved in neurodegeneration. Acts as component of the STAGA transcription coactivator-HAT complex. Mediates the interaction of STAGA complex with the CRX and is involved in CRX-dependent gene activation|comment:mint - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse)|taxid:10090(Mus musculus) - 2017/08/04 2017/08/10 rogid:QxhOtTIxpgF6pvAfVwWQ//A6SY810090 rogid:GLZvR3ov5Le2zbgga3APo9TxEkc10090 rigid:pUIt6jeolxoqAncAjCrYnIUcm3Q false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)