#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P31785-1	uniprotkb:P31785-1	intact:EBI-15569118|ensembl:ENSP00000363318	intact:EBI-15569118|ensembl:ENSP00000363318	psi-mi:p31785-1(display_long)|uniprotkb:IL2RG(gene name)|psi-mi:IL2RG(display_short)|uniprotkb:Interleukin-2 receptor subunit gamma(gene name synonym)|uniprotkb:gammaC(gene name synonym)|uniprotkb:p64(gene name synonym)	psi-mi:p31785-1(display_long)|uniprotkb:IL2RG(gene name)|psi-mi:IL2RG(display_short)|uniprotkb:Interleukin-2 receptor subunit gamma(gene name synonym)|uniprotkb:gammaC(gene name synonym)|uniprotkb:p64(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Stauber et al. (2006)	pubmed:16477002|doi:10.1073/pnas.0511161103|imex:IM-23425	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15569127|imex:IM-23425-1|dip:DIP-197480E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000147168(gene)|ensembl:ENST00000374202(transcript)|intact:EBI-80475(isoform-parent)	ensembl:ENSG00000147168(gene)|ensembl:ENST00000374202(transcript)|intact:EBI-80475(isoform-parent)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7111(trini)|taxid:7111("Trichoplusia ni (Cabbage looper)")	-	2017/08/04	2017/08/10	rogid:Fz1gJI4Qk1jAguOQqWXbAWUb/8o9606	rogid:Fz1gJI4Qk1jAguOQqWXbAWUb/8o9606	rigid:laCJICxyZD70pHnxO4b+JoDy0fI	false	sufficient binding region:23-255	sufficient binding region:23-255	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P60568	uniprotkb:P01589	intact:EBI-12508717|ensembl:ENSP00000226730|uniprotkb:P01585	intact:EBI-8614302|ensembl:ENSP00000369293|uniprotkb:Q5W007|intact:MINT-8146732	psi-mi:il2_human(display_long)|uniprotkb:T-cell growth factor(gene name synonym)|uniprotkb:IL2(gene name)|psi-mi:IL2(display_short)	psi-mi:il2ra_human(display_long)|uniprotkb:IL2RA(gene name)|psi-mi:IL2RA(display_short)|uniprotkb:TAC antigen(gene name synonym)|uniprotkb:p55(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Stauber et al. (2006)	pubmed:16477002|doi:10.1073/pnas.0511161103|imex:IM-23425	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15569145|imex:IM-23425-2|dip:DIP-197481E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000109471(gene)|ensembl:ENST00000226730(transcript)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002366"(leukocyte activation involved in immune response)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0002903"(negative regulation of B cell apoptotic process)|go:"GO:0005125"(cytokine activity)|go:"GO:0005134"(interleukin-2 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010467"(gene expression)|go:"GO:0019209"(kinase activator activity)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031851"(kappa-type opioid receptor binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0034105"(positive regulation of tissue remodeling)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043208"(glycosphingolipid binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0046013"(regulation of T cell homeostatic proliferation)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0050672"(negative regulation of lymphocyte proliferation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1900100"(positive regulation of plasma cell differentiation)|go:"GO:2000320"(negative regulation of T-helper 17 cell differentiation)|interpro:IPR000779(Interleukin-2)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR030477|rcsb pdb:1ILM|rcsb pdb:1ILN|rcsb pdb:1IRL|rcsb pdb:1M47|rcsb pdb:1M48|rcsb pdb:1M49|rcsb pdb:1M4A|rcsb pdb:1M4B|rcsb pdb:1M4C|rcsb pdb:1NBP|rcsb pdb:1PW6|rcsb pdb:1PY2|rcsb pdb:1QVN|rcsb pdb:1Z92|rcsb pdb:2B5I|rcsb pdb:2ERJ|rcsb pdb:3INK|rcsb pdb:3QAZ|rcsb pdb:3QB1|rcsb pdb:4NEJ|rcsb pdb:4NEM|rcsb pdb:5LQB|rcsb pdb:5M5E|rcsb pdb:5UTZ|rcsb pdb:6LX3|rcsb pdb:6LXW|rcsb pdb:6VWU|rcsb pdb:6YE3|rcsb pdb:7DR4|reactome:R-HSA-5673001|reactome:R-HSA-8877330|reactome:R-HSA-9020558|reactome:R-HSA-912526|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|refseq:NP_000577.2|dip:DIP-475N	go:"GO:0002664"(regulation of T cell tolerance induction)|go:"GO:0004911"(interleukin-2 receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005893"(interleukin-2 receptor complex)|go:"GO:0006915"(apoptotic process)|go:"GO:0006924"(activation-induced cell death of T cells)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019976"(interleukin-2 binding)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046013"(regulation of T cell homeostatic proliferation)|go:"GO:0050728"(negative regulation of inflammatory response)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR015486(Interleukin-2 receptor alpha chain)|interpro:IPR035976|rcsb pdb:1ILM|rcsb pdb:1ILN|rcsb pdb:1Z92|rcsb pdb:2B5I|rcsb pdb:2ERJ|rcsb pdb:3IU3|rcsb pdb:3NFP|rcsb pdb:6VWU|rcsb pdb:6YIO|reactome:R-HSA-5673001|reactome:R-HSA-8877330|reactome:R-HSA-9020558|reactome:R-HSA-912526|ensembl:ENSG00000134460(gene)|ensembl:ENST00000379959(transcript)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|refseq:NP_001295171.1|refseq:NP_001295172.1|refseq:NP_000408.1|dip:DIP-1080N	psi-mi:"MI:0465"(dip)	-	comment:mint	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/04	2017/08/10	rogid:a/czfkgidOh/h8ZRYuwUfnv9IU49606	rogid:1R1zaG4yVwFewr+JTsw5St6EQnA9606	rigid:mih8irFWr682/ZluxHiVFW7buL0	false	sufficient binding region:21-153	sufficient binding region:22-233	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P60568	uniprotkb:P14784	intact:EBI-12508717|ensembl:ENSP00000226730|uniprotkb:P01585	intact:EBI-2866779|uniprotkb:B2R765|ensembl:ENSP00000216223	psi-mi:il2_human(display_long)|uniprotkb:T-cell growth factor(gene name synonym)|uniprotkb:IL2(gene name)|psi-mi:IL2(display_short)	psi-mi:il2rb_human(display_long)|uniprotkb:IL2RB(gene name)|psi-mi:IL2RB(display_short)|uniprotkb:High affinity IL-2 receptor subunit beta(gene name synonym)|uniprotkb:p70-75(gene name synonym)|uniprotkb:Interleukin-15 receptor subunit beta(gene name synonym)|uniprotkb:IL15RB(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Stauber et al. (2006)	pubmed:16477002|doi:10.1073/pnas.0511161103|imex:IM-23425	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15569145|imex:IM-23425-2|dip:DIP-197481E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000109471(gene)|ensembl:ENST00000226730(transcript)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002366"(leukocyte activation involved in immune response)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0002903"(negative regulation of B cell apoptotic process)|go:"GO:0005125"(cytokine activity)|go:"GO:0005134"(interleukin-2 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010467"(gene expression)|go:"GO:0019209"(kinase activator activity)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031851"(kappa-type opioid receptor binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0034105"(positive regulation of tissue remodeling)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043208"(glycosphingolipid binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0046013"(regulation of T cell homeostatic proliferation)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0050672"(negative regulation of lymphocyte proliferation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1900100"(positive regulation of plasma cell differentiation)|go:"GO:2000320"(negative regulation of T-helper 17 cell differentiation)|interpro:IPR000779(Interleukin-2)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR030477|rcsb pdb:1ILM|rcsb pdb:1ILN|rcsb pdb:1IRL|rcsb pdb:1M47|rcsb pdb:1M48|rcsb pdb:1M49|rcsb pdb:1M4A|rcsb pdb:1M4B|rcsb pdb:1M4C|rcsb pdb:1NBP|rcsb pdb:1PW6|rcsb pdb:1PY2|rcsb pdb:1QVN|rcsb pdb:1Z92|rcsb pdb:2B5I|rcsb pdb:2ERJ|rcsb pdb:3INK|rcsb pdb:3QAZ|rcsb pdb:3QB1|rcsb pdb:4NEJ|rcsb pdb:4NEM|rcsb pdb:5LQB|rcsb pdb:5M5E|rcsb pdb:5UTZ|rcsb pdb:6LX3|rcsb pdb:6LXW|rcsb pdb:6VWU|rcsb pdb:6YE3|rcsb pdb:7DR4|reactome:R-HSA-5673001|reactome:R-HSA-8877330|reactome:R-HSA-9020558|reactome:R-HSA-912526|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|refseq:NP_000577.2|dip:DIP-475N	refseq:NP_000869.1|refseq:NP_001333151.1|refseq:NP_001333152.1|dip:DIP-43N|ensembl:ENSG00000100385(gene)|ensembl:ENST00000216223(transcript)|go:"GO:0004911"(interleukin-2 receptor activity)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005893"(interleukin-2 receptor complex)|go:"GO:0007165"(signal transduction)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019976"(interleukin-2 binding)|go:"GO:0035723"(interleukin-15-mediated signaling pathway)|go:"GO:0038110"(interleukin-2-mediated signaling pathway)|go:"GO:0042010"(interleukin-15 receptor activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR003531(Short hematopoietin receptor, family 1, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR040951|rcsb pdb:1ILM|rcsb pdb:1ILN|rcsb pdb:2B5I|rcsb pdb:2ERJ|rcsb pdb:3QAZ|rcsb pdb:4GS7|rcsb pdb:5M5E|rcsb pdb:6E8K|reactome:R-HSA-5673001|reactome:R-HSA-8983432|reactome:R-HSA-9020558|reactome:R-HSA-912526	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/04	2017/08/10	rogid:a/czfkgidOh/h8ZRYuwUfnv9IU49606	rogid:fIx5nlom1q65wGMoXZ2SZl3Y4nc9606	rigid:mih8irFWr682/ZluxHiVFW7buL0	false	sufficient binding region:21-153	sufficient binding region:27-232	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P60568	uniprotkb:P31785-1	intact:EBI-12508717|ensembl:ENSP00000226730|uniprotkb:P01585	intact:EBI-15569118|ensembl:ENSP00000363318	psi-mi:il2_human(display_long)|uniprotkb:T-cell growth factor(gene name synonym)|uniprotkb:IL2(gene name)|psi-mi:IL2(display_short)	psi-mi:p31785-1(display_long)|uniprotkb:IL2RG(gene name)|psi-mi:IL2RG(display_short)|uniprotkb:Interleukin-2 receptor subunit gamma(gene name synonym)|uniprotkb:gammaC(gene name synonym)|uniprotkb:p64(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Stauber et al. (2006)	pubmed:16477002|doi:10.1073/pnas.0511161103|imex:IM-23425	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15569145|imex:IM-23425-2|dip:DIP-197481E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000109471(gene)|ensembl:ENST00000226730(transcript)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002366"(leukocyte activation involved in immune response)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0002903"(negative regulation of B cell apoptotic process)|go:"GO:0005125"(cytokine activity)|go:"GO:0005134"(interleukin-2 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010467"(gene expression)|go:"GO:0019209"(kinase activator activity)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031851"(kappa-type opioid receptor binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0034105"(positive regulation of tissue remodeling)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043208"(glycosphingolipid binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0046013"(regulation of T cell homeostatic proliferation)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0050672"(negative regulation of lymphocyte proliferation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1900100"(positive regulation of plasma cell differentiation)|go:"GO:2000320"(negative regulation of T-helper 17 cell differentiation)|interpro:IPR000779(Interleukin-2)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR030477|rcsb pdb:1ILM|rcsb pdb:1ILN|rcsb pdb:1IRL|rcsb pdb:1M47|rcsb pdb:1M48|rcsb pdb:1M49|rcsb pdb:1M4A|rcsb pdb:1M4B|rcsb pdb:1M4C|rcsb pdb:1NBP|rcsb pdb:1PW6|rcsb pdb:1PY2|rcsb pdb:1QVN|rcsb pdb:1Z92|rcsb pdb:2B5I|rcsb pdb:2ERJ|rcsb pdb:3INK|rcsb pdb:3QAZ|rcsb pdb:3QB1|rcsb pdb:4NEJ|rcsb pdb:4NEM|rcsb pdb:5LQB|rcsb pdb:5M5E|rcsb pdb:5UTZ|rcsb pdb:6LX3|rcsb pdb:6LXW|rcsb pdb:6VWU|rcsb pdb:6YE3|rcsb pdb:7DR4|reactome:R-HSA-5673001|reactome:R-HSA-8877330|reactome:R-HSA-9020558|reactome:R-HSA-912526|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|refseq:NP_000577.2|dip:DIP-475N	ensembl:ENSG00000147168(gene)|ensembl:ENST00000374202(transcript)|intact:EBI-80475(isoform-parent)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/04	2017/08/10	rogid:a/czfkgidOh/h8ZRYuwUfnv9IU49606	rogid:Fz1gJI4Qk1jAguOQqWXbAWUb/8o9606	rigid:mih8irFWr682/ZluxHiVFW7buL0	false	sufficient binding region:21-153	sufficient binding region:23-255	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P60568	uniprotkb:P01589	intact:EBI-12508717|ensembl:ENSP00000226730|uniprotkb:P01585	intact:EBI-8614302|ensembl:ENSP00000369293|uniprotkb:Q5W007|intact:MINT-8146732	psi-mi:il2_human(display_long)|uniprotkb:T-cell growth factor(gene name synonym)|uniprotkb:IL2(gene name)|psi-mi:IL2(display_short)	psi-mi:il2ra_human(display_long)|uniprotkb:IL2RA(gene name)|psi-mi:IL2RA(display_short)|uniprotkb:TAC antigen(gene name synonym)|uniprotkb:p55(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Stauber et al. (2006)	pubmed:16477002|doi:10.1073/pnas.0511161103|imex:IM-23425	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15569173|imex:IM-23425-3|dip:DIP-197481E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000109471(gene)|ensembl:ENST00000226730(transcript)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002366"(leukocyte activation involved in immune response)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0002903"(negative regulation of B cell apoptotic process)|go:"GO:0005125"(cytokine activity)|go:"GO:0005134"(interleukin-2 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010467"(gene expression)|go:"GO:0019209"(kinase activator activity)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031851"(kappa-type opioid receptor binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0034105"(positive regulation of tissue remodeling)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043208"(glycosphingolipid binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0046013"(regulation of T cell homeostatic proliferation)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0050672"(negative regulation of lymphocyte proliferation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1900100"(positive regulation of plasma cell differentiation)|go:"GO:2000320"(negative regulation of T-helper 17 cell differentiation)|interpro:IPR000779(Interleukin-2)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR030477|rcsb pdb:1ILM|rcsb pdb:1ILN|rcsb pdb:1IRL|rcsb pdb:1M47|rcsb pdb:1M48|rcsb pdb:1M49|rcsb pdb:1M4A|rcsb pdb:1M4B|rcsb pdb:1M4C|rcsb pdb:1NBP|rcsb pdb:1PW6|rcsb pdb:1PY2|rcsb pdb:1QVN|rcsb pdb:1Z92|rcsb pdb:2B5I|rcsb pdb:2ERJ|rcsb pdb:3INK|rcsb pdb:3QAZ|rcsb pdb:3QB1|rcsb pdb:4NEJ|rcsb pdb:4NEM|rcsb pdb:5LQB|rcsb pdb:5M5E|rcsb pdb:5UTZ|rcsb pdb:6LX3|rcsb pdb:6LXW|rcsb pdb:6VWU|rcsb pdb:6YE3|rcsb pdb:7DR4|reactome:R-HSA-5673001|reactome:R-HSA-8877330|reactome:R-HSA-9020558|reactome:R-HSA-912526|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|refseq:NP_000577.2|dip:DIP-475N	go:"GO:0002664"(regulation of T cell tolerance induction)|go:"GO:0004911"(interleukin-2 receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005893"(interleukin-2 receptor complex)|go:"GO:0006915"(apoptotic process)|go:"GO:0006924"(activation-induced cell death of T cells)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019976"(interleukin-2 binding)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046013"(regulation of T cell homeostatic proliferation)|go:"GO:0050728"(negative regulation of inflammatory response)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR015486(Interleukin-2 receptor alpha chain)|interpro:IPR035976|rcsb pdb:1ILM|rcsb pdb:1ILN|rcsb pdb:1Z92|rcsb pdb:2B5I|rcsb pdb:2ERJ|rcsb pdb:3IU3|rcsb pdb:3NFP|rcsb pdb:6VWU|rcsb pdb:6YIO|reactome:R-HSA-5673001|reactome:R-HSA-8877330|reactome:R-HSA-9020558|reactome:R-HSA-912526|ensembl:ENSG00000134460(gene)|ensembl:ENST00000379959(transcript)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|refseq:NP_001295171.1|refseq:NP_001295172.1|refseq:NP_000408.1|dip:DIP-1080N	psi-mi:"MI:0465"(dip)	-	comment:mint	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/04	2017/08/10	rogid:a/czfkgidOh/h8ZRYuwUfnv9IU49606	rogid:1R1zaG4yVwFewr+JTsw5St6EQnA9606	rigid:mih8irFWr682/ZluxHiVFW7buL0	false	sufficient binding region:21-153	sufficient binding region:22-233	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P60568	uniprotkb:P14784	intact:EBI-12508717|ensembl:ENSP00000226730|uniprotkb:P01585	intact:EBI-2866779|uniprotkb:B2R765|ensembl:ENSP00000216223	psi-mi:il2_human(display_long)|uniprotkb:T-cell growth factor(gene name synonym)|uniprotkb:IL2(gene name)|psi-mi:IL2(display_short)	psi-mi:il2rb_human(display_long)|uniprotkb:IL2RB(gene name)|psi-mi:IL2RB(display_short)|uniprotkb:High affinity IL-2 receptor subunit beta(gene name synonym)|uniprotkb:p70-75(gene name synonym)|uniprotkb:Interleukin-15 receptor subunit beta(gene name synonym)|uniprotkb:IL15RB(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Stauber et al. (2006)	pubmed:16477002|doi:10.1073/pnas.0511161103|imex:IM-23425	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15569173|imex:IM-23425-3|dip:DIP-197481E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000109471(gene)|ensembl:ENST00000226730(transcript)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002366"(leukocyte activation involved in immune response)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0002903"(negative regulation of B cell apoptotic process)|go:"GO:0005125"(cytokine activity)|go:"GO:0005134"(interleukin-2 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010467"(gene expression)|go:"GO:0019209"(kinase activator activity)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031851"(kappa-type opioid receptor binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0034105"(positive regulation of tissue remodeling)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043208"(glycosphingolipid binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0046013"(regulation of T cell homeostatic proliferation)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0050672"(negative regulation of lymphocyte proliferation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1900100"(positive regulation of plasma cell differentiation)|go:"GO:2000320"(negative regulation of T-helper 17 cell differentiation)|interpro:IPR000779(Interleukin-2)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR030477|rcsb pdb:1ILM|rcsb pdb:1ILN|rcsb pdb:1IRL|rcsb pdb:1M47|rcsb pdb:1M48|rcsb pdb:1M49|rcsb pdb:1M4A|rcsb pdb:1M4B|rcsb pdb:1M4C|rcsb pdb:1NBP|rcsb pdb:1PW6|rcsb pdb:1PY2|rcsb pdb:1QVN|rcsb pdb:1Z92|rcsb pdb:2B5I|rcsb pdb:2ERJ|rcsb pdb:3INK|rcsb pdb:3QAZ|rcsb pdb:3QB1|rcsb pdb:4NEJ|rcsb pdb:4NEM|rcsb pdb:5LQB|rcsb pdb:5M5E|rcsb pdb:5UTZ|rcsb pdb:6LX3|rcsb pdb:6LXW|rcsb pdb:6VWU|rcsb pdb:6YE3|rcsb pdb:7DR4|reactome:R-HSA-5673001|reactome:R-HSA-8877330|reactome:R-HSA-9020558|reactome:R-HSA-912526|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|refseq:NP_000577.2|dip:DIP-475N	refseq:NP_000869.1|refseq:NP_001333151.1|refseq:NP_001333152.1|dip:DIP-43N|ensembl:ENSG00000100385(gene)|ensembl:ENST00000216223(transcript)|go:"GO:0004911"(interleukin-2 receptor activity)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005893"(interleukin-2 receptor complex)|go:"GO:0007165"(signal transduction)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019976"(interleukin-2 binding)|go:"GO:0035723"(interleukin-15-mediated signaling pathway)|go:"GO:0038110"(interleukin-2-mediated signaling pathway)|go:"GO:0042010"(interleukin-15 receptor activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR003531(Short hematopoietin receptor, family 1, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR040951|rcsb pdb:1ILM|rcsb pdb:1ILN|rcsb pdb:2B5I|rcsb pdb:2ERJ|rcsb pdb:3QAZ|rcsb pdb:4GS7|rcsb pdb:5M5E|rcsb pdb:6E8K|reactome:R-HSA-5673001|reactome:R-HSA-8983432|reactome:R-HSA-9020558|reactome:R-HSA-912526	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/04	2017/08/10	rogid:a/czfkgidOh/h8ZRYuwUfnv9IU49606	rogid:fIx5nlom1q65wGMoXZ2SZl3Y4nc9606	rigid:mih8irFWr682/ZluxHiVFW7buL0	false	sufficient binding region:21-153	sufficient binding region:27-232	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P60568	uniprotkb:P31785-1	intact:EBI-12508717|ensembl:ENSP00000226730|uniprotkb:P01585	intact:EBI-15569118|ensembl:ENSP00000363318	psi-mi:il2_human(display_long)|uniprotkb:T-cell growth factor(gene name synonym)|uniprotkb:IL2(gene name)|psi-mi:IL2(display_short)	psi-mi:p31785-1(display_long)|uniprotkb:IL2RG(gene name)|psi-mi:IL2RG(display_short)|uniprotkb:Interleukin-2 receptor subunit gamma(gene name synonym)|uniprotkb:gammaC(gene name synonym)|uniprotkb:p64(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Stauber et al. (2006)	pubmed:16477002|doi:10.1073/pnas.0511161103|imex:IM-23425	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15569173|imex:IM-23425-3|dip:DIP-197481E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000109471(gene)|ensembl:ENST00000226730(transcript)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002366"(leukocyte activation involved in immune response)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0002903"(negative regulation of B cell apoptotic process)|go:"GO:0005125"(cytokine activity)|go:"GO:0005134"(interleukin-2 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010467"(gene expression)|go:"GO:0019209"(kinase activator activity)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031851"(kappa-type opioid receptor binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0034105"(positive regulation of tissue remodeling)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043208"(glycosphingolipid binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0046013"(regulation of T cell homeostatic proliferation)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0050672"(negative regulation of lymphocyte proliferation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1900100"(positive regulation of plasma cell differentiation)|go:"GO:2000320"(negative regulation of T-helper 17 cell differentiation)|interpro:IPR000779(Interleukin-2)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR030477|rcsb pdb:1ILM|rcsb pdb:1ILN|rcsb pdb:1IRL|rcsb pdb:1M47|rcsb pdb:1M48|rcsb pdb:1M49|rcsb pdb:1M4A|rcsb pdb:1M4B|rcsb pdb:1M4C|rcsb pdb:1NBP|rcsb pdb:1PW6|rcsb pdb:1PY2|rcsb pdb:1QVN|rcsb pdb:1Z92|rcsb pdb:2B5I|rcsb pdb:2ERJ|rcsb pdb:3INK|rcsb pdb:3QAZ|rcsb pdb:3QB1|rcsb pdb:4NEJ|rcsb pdb:4NEM|rcsb pdb:5LQB|rcsb pdb:5M5E|rcsb pdb:5UTZ|rcsb pdb:6LX3|rcsb pdb:6LXW|rcsb pdb:6VWU|rcsb pdb:6YE3|rcsb pdb:7DR4|reactome:R-HSA-5673001|reactome:R-HSA-8877330|reactome:R-HSA-9020558|reactome:R-HSA-912526|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|refseq:NP_000577.2|dip:DIP-475N	ensembl:ENSG00000147168(gene)|ensembl:ENST00000374202(transcript)|intact:EBI-80475(isoform-parent)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/04	2017/08/10	rogid:a/czfkgidOh/h8ZRYuwUfnv9IU49606	rogid:Fz1gJI4Qk1jAguOQqWXbAWUb/8o9606	rigid:mih8irFWr682/ZluxHiVFW7buL0	false	sufficient binding region:21-153	sufficient binding region:23-255	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)