#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P17693	uniprotkb:P17693	intact:EBI-1043063|ensembl:ENSP00000353472|ensembl:ENSP00000388176|ensembl:ENSP00000389522|ensembl:ENSP00000398200|ensembl:ENSP00000373116|ensembl:ENSP00000405238|ensembl:ENSP00000408773|ensembl:ENSP00000412927|ensembl:ENSP00000447762|ensembl:ENSP00000447780|ensembl:ENSP00000448085|ensembl:ENSP00000448363|ensembl:ENSP00000449291|ensembl:ENSP00000449903	intact:EBI-1043063|ensembl:ENSP00000353472|ensembl:ENSP00000388176|ensembl:ENSP00000389522|ensembl:ENSP00000398200|ensembl:ENSP00000373116|ensembl:ENSP00000405238|ensembl:ENSP00000408773|ensembl:ENSP00000412927|ensembl:ENSP00000447762|ensembl:ENSP00000447780|ensembl:ENSP00000448085|ensembl:ENSP00000448363|ensembl:ENSP00000449291|ensembl:ENSP00000449903	psi-mi:hlag_human(display_long)|uniprotkb:HLAG(gene name synonym)|uniprotkb:HLA-G(gene name)|psi-mi:HLA-G(display_short)|uniprotkb:HLA-6.0(gene name synonym)|uniprotkb:HLA G antigen(gene name synonym)|uniprotkb:MHC class I antigen G(gene name synonym)	psi-mi:hlag_human(display_long)|uniprotkb:HLAG(gene name synonym)|uniprotkb:HLA-G(gene name)|psi-mi:HLA-G(display_short)|uniprotkb:HLA-6.0(gene name synonym)|uniprotkb:HLA G antigen(gene name synonym)|uniprotkb:MHC class I antigen G(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Shiroishi et al. (2006)	pubmed:16455647|imex:IM-26251	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-15485538|imex:IM-26251-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204632(gene)|ensembl:ENSG00000206506(gene)|ensembl:ENSG00000230413(gene)|ensembl:ENSG00000233095(gene)|ensembl:ENSG00000235346(gene)|ensembl:ENSG00000235680(gene)|ensembl:ENSG00000237216(gene)|ensembl:ENST00000360323(transcript)|ensembl:ENST00000383621(transcript)|ensembl:ENST00000423011(transcript)|ensembl:ENST00000423373(transcript)|ensembl:ENST00000428701(transcript)|ensembl:ENST00000428952(transcript)|ensembl:ENST00000444098(transcript)|ensembl:ENST00000449127(transcript)|ensembl:ENST00000546545(transcript)|ensembl:ENST00000546634(transcript)|ensembl:ENST00000547241(transcript)|ensembl:ENST00000547931(transcript)|ensembl:ENST00000550897(transcript)|ensembl:ENST00000553052(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002451"(peripheral B cell tolerance induction)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0002476"(antigen processing and presentation of endogenous peptide antigen via MHC class Ib)|go:"GO:0002645"(positive regulation of tolerance induction)|go:"GO:0002666"(positive regulation of T cell tolerance induction)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0002767"(immune response-inhibiting cell surface receptor signaling pathway)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006968"(cellular defense response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0033106"(cis-Golgi network membrane)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0031527"(filopodium membrane)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0070207"(protein homotrimerization)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000774"(positive regulation of cellular senescence)|go:"GO:2001199"(negative regulation of dendritic cell differentiation)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|mint:P17693|rcsb pdb:1YDP|rcsb pdb:2D31|rcsb pdb:2DYP|rcsb pdb:3BZE|rcsb pdb:3CDG|rcsb pdb:3CII|rcsb pdb:3KYN|rcsb pdb:3KYO|rcsb pdb:6AEE|rcsb pdb:6K60|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|refseq:NP_002118.1|dip:DIP-46121N	ensembl:ENSG00000204632(gene)|ensembl:ENSG00000206506(gene)|ensembl:ENSG00000230413(gene)|ensembl:ENSG00000233095(gene)|ensembl:ENSG00000235346(gene)|ensembl:ENSG00000235680(gene)|ensembl:ENSG00000237216(gene)|ensembl:ENST00000360323(transcript)|ensembl:ENST00000383621(transcript)|ensembl:ENST00000423011(transcript)|ensembl:ENST00000423373(transcript)|ensembl:ENST00000428701(transcript)|ensembl:ENST00000428952(transcript)|ensembl:ENST00000444098(transcript)|ensembl:ENST00000449127(transcript)|ensembl:ENST00000546545(transcript)|ensembl:ENST00000546634(transcript)|ensembl:ENST00000547241(transcript)|ensembl:ENST00000547931(transcript)|ensembl:ENST00000550897(transcript)|ensembl:ENST00000553052(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002451"(peripheral B cell tolerance induction)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0002476"(antigen processing and presentation of endogenous peptide antigen via MHC class Ib)|go:"GO:0002645"(positive regulation of tolerance induction)|go:"GO:0002666"(positive regulation of T cell tolerance induction)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0002767"(immune response-inhibiting cell surface receptor signaling pathway)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006968"(cellular defense response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0033106"(cis-Golgi network membrane)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0031527"(filopodium membrane)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0070207"(protein homotrimerization)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000774"(positive regulation of cellular senescence)|go:"GO:2001199"(negative regulation of dendritic cell differentiation)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|mint:P17693|rcsb pdb:1YDP|rcsb pdb:2D31|rcsb pdb:2DYP|rcsb pdb:3BZE|rcsb pdb:3CDG|rcsb pdb:3CII|rcsb pdb:3KYN|rcsb pdb:3KYO|rcsb pdb:6AEE|rcsb pdb:6K60|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|refseq:NP_002118.1|dip:DIP-46121N	-	-	-	figure legend:1A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/06/01	2017/07/24	rogid:E3xsP+XcQvU64mCe/05DTS9vHQw9606	rogid:E3xsP+XcQvU64mCe/05DTS9vHQw9606	rigid:C3nsKWrdGAKdXkjO+Xiw8kRVuJE	false	sufficient binding region:25-300|mutation disrupting interaction strength:66-66	sufficient binding region:25-300|mutation disrupting interaction strength:66-66	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8NHL6	uniprotkb:P17693	intact:EBI-2805262|uniprotkb:Q8NHK0|uniprotkb:Q8NHJ9|uniprotkb:O75025|uniprotkb:O75024|uniprotkb:A8MXT0|ensembl:ENSP00000480365|ensembl:ENSP00000481700|uniprotkb:A2IXV4	intact:EBI-1043063|ensembl:ENSP00000353472|ensembl:ENSP00000388176|ensembl:ENSP00000389522|ensembl:ENSP00000398200|ensembl:ENSP00000373116|ensembl:ENSP00000405238|ensembl:ENSP00000408773|ensembl:ENSP00000412927|ensembl:ENSP00000447762|ensembl:ENSP00000447780|ensembl:ENSP00000448085|ensembl:ENSP00000448363|ensembl:ENSP00000449291|ensembl:ENSP00000449903	psi-mi:lirb1_human(display_long)|uniprotkb:ILT2(gene name synonym)|uniprotkb:LIR1(gene name synonym)|uniprotkb:MIR7(gene name synonym)|uniprotkb:CD85 antigen-like family member J(gene name synonym)|uniprotkb:Immunoglobulin-like transcript 2(gene name synonym)|uniprotkb:Monocyte/macrophage immunoglobulin-like receptor 7(gene name synonym)|uniprotkb:LILRB1(gene name)|psi-mi:LILRB1(display_short)	psi-mi:hlag_human(display_long)|uniprotkb:HLAG(gene name synonym)|uniprotkb:HLA-G(gene name)|psi-mi:HLA-G(display_short)|uniprotkb:HLA-6.0(gene name synonym)|uniprotkb:HLA G antigen(gene name synonym)|uniprotkb:MHC class I antigen G(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Shiroishi et al. (2006)	pubmed:16455647|imex:IM-26251	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-15485575|imex:IM-26251-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000274669(gene)|ensembl:ENSG00000277807(gene)|ensembl:ENST00000616408(transcript)|ensembl:ENST00000618055(transcript)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002767"(immune response-inhibiting cell surface receptor signaling pathway)|go:"GO:0002774"(Fc receptor mediated inhibitory signaling pathway)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014063"(negative regulation of serotonin secretion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023025"(MHC class Ib protein complex binding)|go:"GO:0023029"(MHC class Ib protein binding)|go:"GO:0030107"(HLA-A specific inhibitory MHC class I receptor activity)|go:"GO:0030109"(HLA-B specific inhibitory MHC class I receptor activity)|go:"GO:0031623"(receptor internalization)|go:"GO:0032393"(MHC class I receptor activity)|go:"GO:0032394"(MHC class Ib receptor activity)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032945"(negative regulation of mononuclear cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046636"(negative regulation of alpha-beta T cell activation)|go:"GO:0051607"(defense response to virus)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071635"(negative regulation of transforming growth factor beta production)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|go:"GO:2001186"(negative regulation of CD8-positive, alpha-beta T cell activation)|go:"GO:2001189"(negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|go:"GO:2001193"(positive regulation of gamma-delta T cell activation involved in immune response)|go:"GO:2001199"(negative regulation of dendritic cell differentiation)|go:"GO:2001205"(negative regulation of osteoclast development)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:Q8NHL6|rcsb pdb:1G0X|rcsb pdb:1P7Q|rcsb pdb:1UFU|rcsb pdb:1UGN|rcsb pdb:1VDG|rcsb pdb:3D2U|rcsb pdb:4LL9|rcsb pdb:4NO0|rcsb pdb:5KNM|rcsb pdb:6AEE|rcsb pdb:6EWA|rcsb pdb:6EWC|rcsb pdb:6EWO|rcsb pdb:6K60|rcsb pdb:6ZDX|rcsb pdb:7KFK|reactome:R-HSA-198933|go:"GO:0097028"(dendritic cell differentiation)|refseq:NP_001265328.2|refseq:NP_001075106.2|refseq:NP_001075107.2|refseq:NP_001075108.2|refseq:NP_001265327.2|refseq:NP_006660.4	ensembl:ENSG00000204632(gene)|ensembl:ENSG00000206506(gene)|ensembl:ENSG00000230413(gene)|ensembl:ENSG00000233095(gene)|ensembl:ENSG00000235346(gene)|ensembl:ENSG00000235680(gene)|ensembl:ENSG00000237216(gene)|ensembl:ENST00000360323(transcript)|ensembl:ENST00000383621(transcript)|ensembl:ENST00000423011(transcript)|ensembl:ENST00000423373(transcript)|ensembl:ENST00000428701(transcript)|ensembl:ENST00000428952(transcript)|ensembl:ENST00000444098(transcript)|ensembl:ENST00000449127(transcript)|ensembl:ENST00000546545(transcript)|ensembl:ENST00000546634(transcript)|ensembl:ENST00000547241(transcript)|ensembl:ENST00000547931(transcript)|ensembl:ENST00000550897(transcript)|ensembl:ENST00000553052(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002451"(peripheral B cell tolerance induction)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0002476"(antigen processing and presentation of endogenous peptide antigen via MHC class Ib)|go:"GO:0002645"(positive regulation of tolerance induction)|go:"GO:0002666"(positive regulation of T cell tolerance induction)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0002767"(immune response-inhibiting cell surface receptor signaling pathway)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006968"(cellular defense response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0033106"(cis-Golgi network membrane)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0031527"(filopodium membrane)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0070207"(protein homotrimerization)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000774"(positive regulation of cellular senescence)|go:"GO:2001199"(negative regulation of dendritic cell differentiation)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|mint:P17693|rcsb pdb:1YDP|rcsb pdb:2D31|rcsb pdb:2DYP|rcsb pdb:3BZE|rcsb pdb:3CDG|rcsb pdb:3CII|rcsb pdb:3KYN|rcsb pdb:3KYO|rcsb pdb:6AEE|rcsb pdb:6K60|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|refseq:NP_002118.1|dip:DIP-46121N	-	-	-	figure legend:1E|comment:"The 1(dimer):2 (LILRB1) molar ratio sample showed only one complex peak  and thus represented the true equilibrium complex stoichiometry."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/06/01	2017/07/24	rogid:c3bdpF4SePNjbOkhewak+Vj98hU9606	rogid:E3xsP+XcQvU64mCe/05DTS9vHQw9606	rigid:We9WKJZnmo+lNIV8QgST/XOuHvg	false	sufficient binding region:24-220..220	sufficient binding region:25-300	2	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8N423	uniprotkb:P17693	intact:EBI-2816428|uniprotkb:Q8NHJ7|uniprotkb:Q8NHJ8|uniprotkb:O75017|uniprotkb:A8MU67|uniprotkb:C9JF29|ensembl:ENSP00000319960|ensembl:ENSP00000375626|ensembl:ENSP00000375628|ensembl:ENSP00000375629|ensembl:ENSP00000410117|ensembl:ENSP00000480302|ensembl:ENSP00000481208|ensembl:ENSP00000482933|ensembl:ENSP00000483553|ensembl:ENSP00000484373	intact:EBI-1043063|ensembl:ENSP00000353472|ensembl:ENSP00000388176|ensembl:ENSP00000389522|ensembl:ENSP00000398200|ensembl:ENSP00000373116|ensembl:ENSP00000405238|ensembl:ENSP00000408773|ensembl:ENSP00000412927|ensembl:ENSP00000447762|ensembl:ENSP00000447780|ensembl:ENSP00000448085|ensembl:ENSP00000448363|ensembl:ENSP00000449291|ensembl:ENSP00000449903	psi-mi:lirb2_human(display_long)|uniprotkb:LILRB2(gene name)|psi-mi:LILRB2(display_short)|uniprotkb:ILT4(gene name synonym)|uniprotkb:LIR2(gene name synonym)|uniprotkb:MIR10(gene name synonym)|uniprotkb:CD85 antigen-like family member D(gene name synonym)|uniprotkb:Immunoglobulin-like transcript 4(gene name synonym)|uniprotkb:Monocyte/macrophage immunoglobulin-like receptor 10(gene name synonym)	psi-mi:hlag_human(display_long)|uniprotkb:HLAG(gene name synonym)|uniprotkb:HLA-G(gene name)|psi-mi:HLA-G(display_short)|uniprotkb:HLA-6.0(gene name synonym)|uniprotkb:HLA G antigen(gene name synonym)|uniprotkb:MHC class I antigen G(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Shiroishi et al. (2006)	pubmed:16455647|imex:IM-26251	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-15485595|imex:IM-26251-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-59888N|ensembl:ENSG00000131042(gene)|ensembl:ENSG00000274513(gene)|ensembl:ENSG00000275463(gene)|ensembl:ENSG00000276146(gene)|ensembl:ENST00000314446(transcript)|ensembl:ENST00000391746(transcript)|ensembl:ENST00000391748(transcript)|ensembl:ENST00000391749(transcript)|ensembl:ENST00000434421(transcript)|ensembl:ENST00000610886(transcript)|ensembl:ENST00000617341(transcript)|ensembl:ENST00000617886(transcript)|ensembl:ENST00000618392(transcript)|ensembl:ENST00000618705(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002578"(negative regulation of antigen processing and presentation)|go:"GO:0002645"(positive regulation of tolerance induction)|go:"GO:0002666"(positive regulation of T cell tolerance induction)|go:"GO:0002767"(immune response-inhibiting cell surface receptor signaling pathway)|go:"GO:0002774"(Fc receptor mediated inhibitory signaling pathway)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007611"(learning or memory)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0023025"(MHC class Ib protein complex binding)|go:"GO:0023029"(MHC class Ib protein binding)|go:"GO:0032396"(inhibitory MHC class I receptor activity)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:0140105"(interleukin-10-mediated signaling pathway)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1905875"(negative regulation of postsynaptic density organization)|go:"GO:2000524"(negative regulation of T cell costimulation)|go:"GO:2001198"(regulation of dendritic cell differentiation)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2DYP|rcsb pdb:2GW5|rcsb pdb:4LLA|rcsb pdb:6AED|rcsb pdb:6BCS|reactome:R-HSA-198933|reactome:R-HSA-6798695	ensembl:ENSG00000204632(gene)|ensembl:ENSG00000206506(gene)|ensembl:ENSG00000230413(gene)|ensembl:ENSG00000233095(gene)|ensembl:ENSG00000235346(gene)|ensembl:ENSG00000235680(gene)|ensembl:ENSG00000237216(gene)|ensembl:ENST00000360323(transcript)|ensembl:ENST00000383621(transcript)|ensembl:ENST00000423011(transcript)|ensembl:ENST00000423373(transcript)|ensembl:ENST00000428701(transcript)|ensembl:ENST00000428952(transcript)|ensembl:ENST00000444098(transcript)|ensembl:ENST00000449127(transcript)|ensembl:ENST00000546545(transcript)|ensembl:ENST00000546634(transcript)|ensembl:ENST00000547241(transcript)|ensembl:ENST00000547931(transcript)|ensembl:ENST00000550897(transcript)|ensembl:ENST00000553052(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002451"(peripheral B cell tolerance induction)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0002476"(antigen processing and presentation of endogenous peptide antigen via MHC class Ib)|go:"GO:0002645"(positive regulation of tolerance induction)|go:"GO:0002666"(positive regulation of T cell tolerance induction)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0002767"(immune response-inhibiting cell surface receptor signaling pathway)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006968"(cellular defense response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0033106"(cis-Golgi network membrane)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0031527"(filopodium membrane)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0070207"(protein homotrimerization)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000774"(positive regulation of cellular senescence)|go:"GO:2001199"(negative regulation of dendritic cell differentiation)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|mint:P17693|rcsb pdb:1YDP|rcsb pdb:2D31|rcsb pdb:2DYP|rcsb pdb:3BZE|rcsb pdb:3CDG|rcsb pdb:3CII|rcsb pdb:3KYN|rcsb pdb:3KYO|rcsb pdb:6AEE|rcsb pdb:6K60|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|refseq:NP_002118.1|dip:DIP-46121N	-	-	-	figure legend:1G|comment:"The 1(dimer):2 (LILRB2) molar ratio sample showed only one complex peak and thus represented the true equilibrium complex stoichiometry."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/06/01	2017/07/24	rogid:nFaZ5NEqw5u/3Du7Mi6fJpEQEdo9606	rogid:E3xsP+XcQvU64mCe/05DTS9vHQw9606	rigid:yT+XLgcf3zp0zEFT9a+PU7aLgkI	false	sufficient binding region:24-221..221	sufficient binding region:25-300	2	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P17693	uniprotkb:P17693	intact:EBI-1043063|ensembl:ENSP00000353472|ensembl:ENSP00000388176|ensembl:ENSP00000389522|ensembl:ENSP00000398200|ensembl:ENSP00000373116|ensembl:ENSP00000405238|ensembl:ENSP00000408773|ensembl:ENSP00000412927|ensembl:ENSP00000447762|ensembl:ENSP00000447780|ensembl:ENSP00000448085|ensembl:ENSP00000448363|ensembl:ENSP00000449291|ensembl:ENSP00000449903	intact:EBI-1043063|ensembl:ENSP00000353472|ensembl:ENSP00000388176|ensembl:ENSP00000389522|ensembl:ENSP00000398200|ensembl:ENSP00000373116|ensembl:ENSP00000405238|ensembl:ENSP00000408773|ensembl:ENSP00000412927|ensembl:ENSP00000447762|ensembl:ENSP00000447780|ensembl:ENSP00000448085|ensembl:ENSP00000448363|ensembl:ENSP00000449291|ensembl:ENSP00000449903	psi-mi:hlag_human(display_long)|uniprotkb:HLAG(gene name synonym)|uniprotkb:HLA-G(gene name)|psi-mi:HLA-G(display_short)|uniprotkb:HLA-6.0(gene name synonym)|uniprotkb:HLA G antigen(gene name synonym)|uniprotkb:MHC class I antigen G(gene name synonym)	psi-mi:hlag_human(display_long)|uniprotkb:HLAG(gene name synonym)|uniprotkb:HLA-G(gene name)|psi-mi:HLA-G(display_short)|uniprotkb:HLA-6.0(gene name synonym)|uniprotkb:HLA G antigen(gene name synonym)|uniprotkb:MHC class I antigen G(gene name synonym)	psi-mi:"MI:0808"(comigration in sds page)	Shiroishi et al. (2006)	pubmed:16455647|imex:IM-26251	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-15485544|imex:IM-26251-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204632(gene)|ensembl:ENSG00000206506(gene)|ensembl:ENSG00000230413(gene)|ensembl:ENSG00000233095(gene)|ensembl:ENSG00000235346(gene)|ensembl:ENSG00000235680(gene)|ensembl:ENSG00000237216(gene)|ensembl:ENST00000360323(transcript)|ensembl:ENST00000383621(transcript)|ensembl:ENST00000423011(transcript)|ensembl:ENST00000423373(transcript)|ensembl:ENST00000428701(transcript)|ensembl:ENST00000428952(transcript)|ensembl:ENST00000444098(transcript)|ensembl:ENST00000449127(transcript)|ensembl:ENST00000546545(transcript)|ensembl:ENST00000546634(transcript)|ensembl:ENST00000547241(transcript)|ensembl:ENST00000547931(transcript)|ensembl:ENST00000550897(transcript)|ensembl:ENST00000553052(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002451"(peripheral B cell tolerance induction)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0002476"(antigen processing and presentation of endogenous peptide antigen via MHC class Ib)|go:"GO:0002645"(positive regulation of tolerance induction)|go:"GO:0002666"(positive regulation of T cell tolerance induction)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0002767"(immune response-inhibiting cell surface receptor signaling pathway)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006968"(cellular defense response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0033106"(cis-Golgi network membrane)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0031527"(filopodium membrane)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0070207"(protein homotrimerization)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000774"(positive regulation of cellular senescence)|go:"GO:2001199"(negative regulation of dendritic cell differentiation)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|mint:P17693|rcsb pdb:1YDP|rcsb pdb:2D31|rcsb pdb:2DYP|rcsb pdb:3BZE|rcsb pdb:3CDG|rcsb pdb:3CII|rcsb pdb:3KYN|rcsb pdb:3KYO|rcsb pdb:6AEE|rcsb pdb:6K60|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|refseq:NP_002118.1|dip:DIP-46121N	ensembl:ENSG00000204632(gene)|ensembl:ENSG00000206506(gene)|ensembl:ENSG00000230413(gene)|ensembl:ENSG00000233095(gene)|ensembl:ENSG00000235346(gene)|ensembl:ENSG00000235680(gene)|ensembl:ENSG00000237216(gene)|ensembl:ENST00000360323(transcript)|ensembl:ENST00000383621(transcript)|ensembl:ENST00000423011(transcript)|ensembl:ENST00000423373(transcript)|ensembl:ENST00000428701(transcript)|ensembl:ENST00000428952(transcript)|ensembl:ENST00000444098(transcript)|ensembl:ENST00000449127(transcript)|ensembl:ENST00000546545(transcript)|ensembl:ENST00000546634(transcript)|ensembl:ENST00000547241(transcript)|ensembl:ENST00000547931(transcript)|ensembl:ENST00000550897(transcript)|ensembl:ENST00000553052(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002451"(peripheral B cell tolerance induction)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0002476"(antigen processing and presentation of endogenous peptide antigen via MHC class Ib)|go:"GO:0002645"(positive regulation of tolerance induction)|go:"GO:0002666"(positive regulation of T cell tolerance induction)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0002767"(immune response-inhibiting cell surface receptor signaling pathway)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006968"(cellular defense response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0033106"(cis-Golgi network membrane)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0031527"(filopodium membrane)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0070207"(protein homotrimerization)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000774"(positive regulation of cellular senescence)|go:"GO:2001199"(negative regulation of dendritic cell differentiation)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|mint:P17693|rcsb pdb:1YDP|rcsb pdb:2D31|rcsb pdb:2DYP|rcsb pdb:3BZE|rcsb pdb:3CDG|rcsb pdb:3CII|rcsb pdb:3KYN|rcsb pdb:3KYO|rcsb pdb:6AEE|rcsb pdb:6K60|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|refseq:NP_002118.1|dip:DIP-46121N	-	-	-	figure legend:1B|comment:Beta-2-microglobulin was also present on the gel.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2017/06/01	2017/07/24	rogid:E3xsP+XcQvU64mCe/05DTS9vHQw9606	rogid:E3xsP+XcQvU64mCe/05DTS9vHQw9606	rigid:C3nsKWrdGAKdXkjO+Xiw8kRVuJE	false	sufficient binding region:25-300|mutation disrupting interaction strength:66-66	sufficient binding region:25-300|mutation disrupting interaction strength:66-66	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P17693	uniprotkb:P17693	intact:EBI-1043063|ensembl:ENSP00000353472|ensembl:ENSP00000388176|ensembl:ENSP00000389522|ensembl:ENSP00000398200|ensembl:ENSP00000373116|ensembl:ENSP00000405238|ensembl:ENSP00000408773|ensembl:ENSP00000412927|ensembl:ENSP00000447762|ensembl:ENSP00000447780|ensembl:ENSP00000448085|ensembl:ENSP00000448363|ensembl:ENSP00000449291|ensembl:ENSP00000449903	intact:EBI-1043063|ensembl:ENSP00000353472|ensembl:ENSP00000388176|ensembl:ENSP00000389522|ensembl:ENSP00000398200|ensembl:ENSP00000373116|ensembl:ENSP00000405238|ensembl:ENSP00000408773|ensembl:ENSP00000412927|ensembl:ENSP00000447762|ensembl:ENSP00000447780|ensembl:ENSP00000448085|ensembl:ENSP00000448363|ensembl:ENSP00000449291|ensembl:ENSP00000449903	psi-mi:hlag_human(display_long)|uniprotkb:HLAG(gene name synonym)|uniprotkb:HLA-G(gene name)|psi-mi:HLA-G(display_short)|uniprotkb:HLA-6.0(gene name synonym)|uniprotkb:HLA G antigen(gene name synonym)|uniprotkb:MHC class I antigen G(gene name synonym)	psi-mi:hlag_human(display_long)|uniprotkb:HLAG(gene name synonym)|uniprotkb:HLA-G(gene name)|psi-mi:HLA-G(display_short)|uniprotkb:HLA-6.0(gene name synonym)|uniprotkb:HLA G antigen(gene name synonym)|uniprotkb:MHC class I antigen G(gene name synonym)	psi-mi:"MI:0404"(comigration in non denaturing gel electrophoresis)	Shiroishi et al. (2006)	pubmed:16455647|imex:IM-26251	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-15485551|imex:IM-26251-23	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204632(gene)|ensembl:ENSG00000206506(gene)|ensembl:ENSG00000230413(gene)|ensembl:ENSG00000233095(gene)|ensembl:ENSG00000235346(gene)|ensembl:ENSG00000235680(gene)|ensembl:ENSG00000237216(gene)|ensembl:ENST00000360323(transcript)|ensembl:ENST00000383621(transcript)|ensembl:ENST00000423011(transcript)|ensembl:ENST00000423373(transcript)|ensembl:ENST00000428701(transcript)|ensembl:ENST00000428952(transcript)|ensembl:ENST00000444098(transcript)|ensembl:ENST00000449127(transcript)|ensembl:ENST00000546545(transcript)|ensembl:ENST00000546634(transcript)|ensembl:ENST00000547241(transcript)|ensembl:ENST00000547931(transcript)|ensembl:ENST00000550897(transcript)|ensembl:ENST00000553052(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002451"(peripheral B cell tolerance induction)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0002476"(antigen processing and presentation of endogenous peptide antigen via MHC class Ib)|go:"GO:0002645"(positive regulation of tolerance induction)|go:"GO:0002666"(positive regulation of T cell tolerance induction)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0002767"(immune response-inhibiting cell surface receptor signaling pathway)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006968"(cellular defense response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0033106"(cis-Golgi network membrane)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0031527"(filopodium membrane)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0070207"(protein homotrimerization)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000774"(positive regulation of cellular senescence)|go:"GO:2001199"(negative regulation of dendritic cell differentiation)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|mint:P17693|rcsb pdb:1YDP|rcsb pdb:2D31|rcsb pdb:2DYP|rcsb pdb:3BZE|rcsb pdb:3CDG|rcsb pdb:3CII|rcsb pdb:3KYN|rcsb pdb:3KYO|rcsb pdb:6AEE|rcsb pdb:6K60|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|refseq:NP_002118.1|dip:DIP-46121N	ensembl:ENSG00000204632(gene)|ensembl:ENSG00000206506(gene)|ensembl:ENSG00000230413(gene)|ensembl:ENSG00000233095(gene)|ensembl:ENSG00000235346(gene)|ensembl:ENSG00000235680(gene)|ensembl:ENSG00000237216(gene)|ensembl:ENST00000360323(transcript)|ensembl:ENST00000383621(transcript)|ensembl:ENST00000423011(transcript)|ensembl:ENST00000423373(transcript)|ensembl:ENST00000428701(transcript)|ensembl:ENST00000428952(transcript)|ensembl:ENST00000444098(transcript)|ensembl:ENST00000449127(transcript)|ensembl:ENST00000546545(transcript)|ensembl:ENST00000546634(transcript)|ensembl:ENST00000547241(transcript)|ensembl:ENST00000547931(transcript)|ensembl:ENST00000550897(transcript)|ensembl:ENST00000553052(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002451"(peripheral B cell tolerance induction)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0002476"(antigen processing and presentation of endogenous peptide antigen via MHC class Ib)|go:"GO:0002645"(positive regulation of tolerance induction)|go:"GO:0002666"(positive regulation of T cell tolerance induction)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0002767"(immune response-inhibiting cell surface receptor signaling pathway)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006968"(cellular defense response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0033106"(cis-Golgi network membrane)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0031527"(filopodium membrane)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0070207"(protein homotrimerization)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000774"(positive regulation of cellular senescence)|go:"GO:2001199"(negative regulation of dendritic cell differentiation)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|mint:P17693|rcsb pdb:1YDP|rcsb pdb:2D31|rcsb pdb:2DYP|rcsb pdb:3BZE|rcsb pdb:3CDG|rcsb pdb:3CII|rcsb pdb:3KYN|rcsb pdb:3KYO|rcsb pdb:6AEE|rcsb pdb:6K60|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|refseq:NP_002118.1|dip:DIP-46121N	-	-	-	figure legend:1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2017/06/01	2017/07/24	rogid:E3xsP+XcQvU64mCe/05DTS9vHQw9606	rogid:E3xsP+XcQvU64mCe/05DTS9vHQw9606	rigid:C3nsKWrdGAKdXkjO+Xiw8kRVuJE	false	sufficient binding region:25-300|mutation disrupting interaction strength:66-66	sufficient binding region:25-300|mutation disrupting interaction strength:66-66	2	0	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:Q8NHL6	uniprotkb:P17693	intact:EBI-2805262|uniprotkb:Q8NHK0|uniprotkb:Q8NHJ9|uniprotkb:O75025|uniprotkb:O75024|uniprotkb:A8MXT0|ensembl:ENSP00000480365|ensembl:ENSP00000481700|uniprotkb:A2IXV4	intact:EBI-1043063|ensembl:ENSP00000353472|ensembl:ENSP00000388176|ensembl:ENSP00000389522|ensembl:ENSP00000398200|ensembl:ENSP00000373116|ensembl:ENSP00000405238|ensembl:ENSP00000408773|ensembl:ENSP00000412927|ensembl:ENSP00000447762|ensembl:ENSP00000447780|ensembl:ENSP00000448085|ensembl:ENSP00000448363|ensembl:ENSP00000449291|ensembl:ENSP00000449903	psi-mi:lirb1_human(display_long)|uniprotkb:ILT2(gene name synonym)|uniprotkb:LIR1(gene name synonym)|uniprotkb:MIR7(gene name synonym)|uniprotkb:CD85 antigen-like family member J(gene name synonym)|uniprotkb:Immunoglobulin-like transcript 2(gene name synonym)|uniprotkb:Monocyte/macrophage immunoglobulin-like receptor 7(gene name synonym)|uniprotkb:LILRB1(gene name)|psi-mi:LILRB1(display_short)	psi-mi:hlag_human(display_long)|uniprotkb:HLAG(gene name synonym)|uniprotkb:HLA-G(gene name)|psi-mi:HLA-G(display_short)|uniprotkb:HLA-6.0(gene name synonym)|uniprotkb:HLA G antigen(gene name synonym)|uniprotkb:MHC class I antigen G(gene name synonym)	psi-mi:"MI:0404"(comigration in non denaturing gel electrophoresis)	Shiroishi et al. (2006)	pubmed:16455647|imex:IM-26251	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-15485559|imex:IM-26251-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000274669(gene)|ensembl:ENSG00000277807(gene)|ensembl:ENST00000616408(transcript)|ensembl:ENST00000618055(transcript)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002767"(immune response-inhibiting cell surface receptor signaling pathway)|go:"GO:0002774"(Fc receptor mediated inhibitory signaling pathway)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014063"(negative regulation of serotonin secretion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023025"(MHC class Ib protein complex binding)|go:"GO:0023029"(MHC class Ib protein binding)|go:"GO:0030107"(HLA-A specific inhibitory MHC class I receptor activity)|go:"GO:0030109"(HLA-B specific inhibitory MHC class I receptor activity)|go:"GO:0031623"(receptor internalization)|go:"GO:0032393"(MHC class I receptor activity)|go:"GO:0032394"(MHC class Ib receptor activity)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032945"(negative regulation of mononuclear cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046636"(negative regulation of alpha-beta T cell activation)|go:"GO:0051607"(defense response to virus)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071635"(negative regulation of transforming growth factor beta production)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|go:"GO:2001186"(negative regulation of CD8-positive, alpha-beta T cell activation)|go:"GO:2001189"(negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|go:"GO:2001193"(positive regulation of gamma-delta T cell activation involved in immune response)|go:"GO:2001199"(negative regulation of dendritic cell differentiation)|go:"GO:2001205"(negative regulation of osteoclast development)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:Q8NHL6|rcsb pdb:1G0X|rcsb pdb:1P7Q|rcsb pdb:1UFU|rcsb pdb:1UGN|rcsb pdb:1VDG|rcsb pdb:3D2U|rcsb pdb:4LL9|rcsb pdb:4NO0|rcsb pdb:5KNM|rcsb pdb:6AEE|rcsb pdb:6EWA|rcsb pdb:6EWC|rcsb pdb:6EWO|rcsb pdb:6K60|rcsb pdb:6ZDX|rcsb pdb:7KFK|reactome:R-HSA-198933|go:"GO:0097028"(dendritic cell differentiation)|refseq:NP_001265328.2|refseq:NP_001075106.2|refseq:NP_001075107.2|refseq:NP_001075108.2|refseq:NP_001265327.2|refseq:NP_006660.4	ensembl:ENSG00000204632(gene)|ensembl:ENSG00000206506(gene)|ensembl:ENSG00000230413(gene)|ensembl:ENSG00000233095(gene)|ensembl:ENSG00000235346(gene)|ensembl:ENSG00000235680(gene)|ensembl:ENSG00000237216(gene)|ensembl:ENST00000360323(transcript)|ensembl:ENST00000383621(transcript)|ensembl:ENST00000423011(transcript)|ensembl:ENST00000423373(transcript)|ensembl:ENST00000428701(transcript)|ensembl:ENST00000428952(transcript)|ensembl:ENST00000444098(transcript)|ensembl:ENST00000449127(transcript)|ensembl:ENST00000546545(transcript)|ensembl:ENST00000546634(transcript)|ensembl:ENST00000547241(transcript)|ensembl:ENST00000547931(transcript)|ensembl:ENST00000550897(transcript)|ensembl:ENST00000553052(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002451"(peripheral B cell tolerance induction)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0002476"(antigen processing and presentation of endogenous peptide antigen via MHC class Ib)|go:"GO:0002645"(positive regulation of tolerance induction)|go:"GO:0002666"(positive regulation of T cell tolerance induction)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0002767"(immune response-inhibiting cell surface receptor signaling pathway)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006968"(cellular defense response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0033106"(cis-Golgi network membrane)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0031527"(filopodium membrane)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0070207"(protein homotrimerization)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000774"(positive regulation of cellular senescence)|go:"GO:2001199"(negative regulation of dendritic cell differentiation)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|mint:P17693|rcsb pdb:1YDP|rcsb pdb:2D31|rcsb pdb:2DYP|rcsb pdb:3BZE|rcsb pdb:3CDG|rcsb pdb:3CII|rcsb pdb:3KYN|rcsb pdb:3KYO|rcsb pdb:6AEE|rcsb pdb:6K60|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|refseq:NP_002118.1|dip:DIP-46121N	-	-	-	figure legend:1D|comment:"the full complex was composed of one HLA-G dimer and two LILRB1s (1:2 complex)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/06/01	2017/07/24	rogid:c3bdpF4SePNjbOkhewak+Vj98hU9606	rogid:E3xsP+XcQvU64mCe/05DTS9vHQw9606	rigid:We9WKJZnmo+lNIV8QgST/XOuHvg	false	sufficient binding region:24-220..220	sufficient binding region:25-300	2	2	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:Q8N423	uniprotkb:P17693	intact:EBI-2816428|uniprotkb:Q8NHJ7|uniprotkb:Q8NHJ8|uniprotkb:O75017|uniprotkb:A8MU67|uniprotkb:C9JF29|ensembl:ENSP00000319960|ensembl:ENSP00000375626|ensembl:ENSP00000375628|ensembl:ENSP00000375629|ensembl:ENSP00000410117|ensembl:ENSP00000480302|ensembl:ENSP00000481208|ensembl:ENSP00000482933|ensembl:ENSP00000483553|ensembl:ENSP00000484373	intact:EBI-1043063|ensembl:ENSP00000353472|ensembl:ENSP00000388176|ensembl:ENSP00000389522|ensembl:ENSP00000398200|ensembl:ENSP00000373116|ensembl:ENSP00000405238|ensembl:ENSP00000408773|ensembl:ENSP00000412927|ensembl:ENSP00000447762|ensembl:ENSP00000447780|ensembl:ENSP00000448085|ensembl:ENSP00000448363|ensembl:ENSP00000449291|ensembl:ENSP00000449903	psi-mi:lirb2_human(display_long)|uniprotkb:LILRB2(gene name)|psi-mi:LILRB2(display_short)|uniprotkb:ILT4(gene name synonym)|uniprotkb:LIR2(gene name synonym)|uniprotkb:MIR10(gene name synonym)|uniprotkb:CD85 antigen-like family member D(gene name synonym)|uniprotkb:Immunoglobulin-like transcript 4(gene name synonym)|uniprotkb:Monocyte/macrophage immunoglobulin-like receptor 10(gene name synonym)	psi-mi:hlag_human(display_long)|uniprotkb:HLAG(gene name synonym)|uniprotkb:HLA-G(gene name)|psi-mi:HLA-G(display_short)|uniprotkb:HLA-6.0(gene name synonym)|uniprotkb:HLA G antigen(gene name synonym)|uniprotkb:MHC class I antigen G(gene name synonym)	psi-mi:"MI:0404"(comigration in non denaturing gel electrophoresis)	Shiroishi et al. (2006)	pubmed:16455647|imex:IM-26251	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-15485586|imex:IM-26251-25	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-59888N|ensembl:ENSG00000131042(gene)|ensembl:ENSG00000274513(gene)|ensembl:ENSG00000275463(gene)|ensembl:ENSG00000276146(gene)|ensembl:ENST00000314446(transcript)|ensembl:ENST00000391746(transcript)|ensembl:ENST00000391748(transcript)|ensembl:ENST00000391749(transcript)|ensembl:ENST00000434421(transcript)|ensembl:ENST00000610886(transcript)|ensembl:ENST00000617341(transcript)|ensembl:ENST00000617886(transcript)|ensembl:ENST00000618392(transcript)|ensembl:ENST00000618705(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002578"(negative regulation of antigen processing and presentation)|go:"GO:0002645"(positive regulation of tolerance induction)|go:"GO:0002666"(positive regulation of T cell tolerance induction)|go:"GO:0002767"(immune response-inhibiting cell surface receptor signaling pathway)|go:"GO:0002774"(Fc receptor mediated inhibitory signaling pathway)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007611"(learning or memory)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0023025"(MHC class Ib protein complex binding)|go:"GO:0023029"(MHC class Ib protein binding)|go:"GO:0032396"(inhibitory MHC class I receptor activity)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:0140105"(interleukin-10-mediated signaling pathway)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1905875"(negative regulation of postsynaptic density organization)|go:"GO:2000524"(negative regulation of T cell costimulation)|go:"GO:2001198"(regulation of dendritic cell differentiation)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2DYP|rcsb pdb:2GW5|rcsb pdb:4LLA|rcsb pdb:6AED|rcsb pdb:6BCS|reactome:R-HSA-198933|reactome:R-HSA-6798695	ensembl:ENSG00000204632(gene)|ensembl:ENSG00000206506(gene)|ensembl:ENSG00000230413(gene)|ensembl:ENSG00000233095(gene)|ensembl:ENSG00000235346(gene)|ensembl:ENSG00000235680(gene)|ensembl:ENSG00000237216(gene)|ensembl:ENST00000360323(transcript)|ensembl:ENST00000383621(transcript)|ensembl:ENST00000423011(transcript)|ensembl:ENST00000423373(transcript)|ensembl:ENST00000428701(transcript)|ensembl:ENST00000428952(transcript)|ensembl:ENST00000444098(transcript)|ensembl:ENST00000449127(transcript)|ensembl:ENST00000546545(transcript)|ensembl:ENST00000546634(transcript)|ensembl:ENST00000547241(transcript)|ensembl:ENST00000547931(transcript)|ensembl:ENST00000550897(transcript)|ensembl:ENST00000553052(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002451"(peripheral B cell tolerance induction)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0002476"(antigen processing and presentation of endogenous peptide antigen via MHC class Ib)|go:"GO:0002645"(positive regulation of tolerance induction)|go:"GO:0002666"(positive regulation of T cell tolerance induction)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0002767"(immune response-inhibiting cell surface receptor signaling pathway)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006968"(cellular defense response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0033106"(cis-Golgi network membrane)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0031527"(filopodium membrane)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0070207"(protein homotrimerization)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000774"(positive regulation of cellular senescence)|go:"GO:2001199"(negative regulation of dendritic cell differentiation)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|mint:P17693|rcsb pdb:1YDP|rcsb pdb:2D31|rcsb pdb:2DYP|rcsb pdb:3BZE|rcsb pdb:3CDG|rcsb pdb:3CII|rcsb pdb:3KYN|rcsb pdb:3KYO|rcsb pdb:6AEE|rcsb pdb:6K60|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|refseq:NP_002118.1|dip:DIP-46121N	-	-	-	figure legend:1F|comment:"the full complex was composed of one HLA-G dimer and two LILRB2s (1:2 complex)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/06/01	2017/07/24	rogid:nFaZ5NEqw5u/3Du7Mi6fJpEQEdo9606	rogid:E3xsP+XcQvU64mCe/05DTS9vHQw9606	rigid:yT+XLgcf3zp0zEFT9a+PU7aLgkI	false	sufficient binding region:24-221..221	sufficient binding region:25-300	2	2	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:P16104	uniprotkb:P17693	intact:EBI-494830|uniprotkb:Q4ZGJ7|uniprotkb:Q6IAS5|ensembl:ENSP00000364310|ensembl:ENSP00000434024	intact:EBI-1043063|ensembl:ENSP00000353472|ensembl:ENSP00000388176|ensembl:ENSP00000389522|ensembl:ENSP00000398200|ensembl:ENSP00000373116|ensembl:ENSP00000405238|ensembl:ENSP00000408773|ensembl:ENSP00000412927|ensembl:ENSP00000447762|ensembl:ENSP00000447780|ensembl:ENSP00000448085|ensembl:ENSP00000448363|ensembl:ENSP00000449291|ensembl:ENSP00000449903	psi-mi:h2ax_human(display_long)|uniprotkb:H2AX(gene name)|psi-mi:H2AX(display_short)|uniprotkb:H2AFX(gene name synonym)|uniprotkb:Histone H2A.X(gene name synonym)	psi-mi:hlag_human(display_long)|uniprotkb:HLAG(gene name synonym)|uniprotkb:HLA-G(gene name)|psi-mi:HLA-G(display_short)|uniprotkb:HLA-6.0(gene name synonym)|uniprotkb:HLA G antigen(gene name synonym)|uniprotkb:MHC class I antigen G(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Shiroishi et al. (2006)	pubmed:16455647|imex:IM-26251	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-15485613|imex:IM-26251-9|wwpdb:2d31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000188486(gene)|ensembl:ENST00000375167(transcript)|ensembl:ENST00000530167(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000786"(nucleosome)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0001741"(XY body)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|refseq:NP_002096.1|dip:DIP-33604N|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-3214858|reactome:R-HSA-427359|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5334118|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5625886|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-606279|reactome:R-HSA-69473|reactome:R-HSA-73728|reactome:R-HSA-73772|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9670095|reactome:R-HSA-9710421|reactome:R-HSA-977225|go:"GO:0005813"(centrosome)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006342"|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042393"(histone binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0090398"(cellular senescence)|go:"GO:0090734"(site of DNA damage)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P16104|rcsb pdb:1YDP|rcsb pdb:2AZM|rcsb pdb:2D31|rcsb pdb:2DYP|rcsb pdb:3SHV|rcsb pdb:3SQD|rcsb pdb:3SZM|rcsb pdb:3U3Z|rcsb pdb:6K1I|rcsb pdb:6K1J|rcsb pdb:6K1K	ensembl:ENSG00000204632(gene)|ensembl:ENSG00000206506(gene)|ensembl:ENSG00000230413(gene)|ensembl:ENSG00000233095(gene)|ensembl:ENSG00000235346(gene)|ensembl:ENSG00000235680(gene)|ensembl:ENSG00000237216(gene)|ensembl:ENST00000360323(transcript)|ensembl:ENST00000383621(transcript)|ensembl:ENST00000423011(transcript)|ensembl:ENST00000423373(transcript)|ensembl:ENST00000428701(transcript)|ensembl:ENST00000428952(transcript)|ensembl:ENST00000444098(transcript)|ensembl:ENST00000449127(transcript)|ensembl:ENST00000546545(transcript)|ensembl:ENST00000546634(transcript)|ensembl:ENST00000547241(transcript)|ensembl:ENST00000547931(transcript)|ensembl:ENST00000550897(transcript)|ensembl:ENST00000553052(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002451"(peripheral B cell tolerance induction)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0002476"(antigen processing and presentation of endogenous peptide antigen via MHC class Ib)|go:"GO:0002645"(positive regulation of tolerance induction)|go:"GO:0002666"(positive regulation of T cell tolerance induction)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0002767"(immune response-inhibiting cell surface receptor signaling pathway)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006968"(cellular defense response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0033106"(cis-Golgi network membrane)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0031527"(filopodium membrane)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0070207"(protein homotrimerization)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000774"(positive regulation of cellular senescence)|go:"GO:2001199"(negative regulation of dendritic cell differentiation)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|mint:P17693|rcsb pdb:1YDP|rcsb pdb:2D31|rcsb pdb:2DYP|rcsb pdb:3BZE|rcsb pdb:3CDG|rcsb pdb:3CII|rcsb pdb:3KYN|rcsb pdb:3KYO|rcsb pdb:6AEE|rcsb pdb:6K60|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|refseq:NP_002118.1|dip:DIP-46121N	-	-	-	figure legend:Table 1|3d-resolution:3.2 A|3d-r-factors:RFree = 0.298  RWork = 0.235|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/06/01	2017/07/24	rogid:VQoEp3F8lEBTOj+PDDUzrJCQNZA9606	rogid:E3xsP+XcQvU64mCe/05DTS9vHQw9606	rigid:hXEw5iprKjbH0eD4Tn4hqIBJZfk	false	sufficient binding region:78-86	sufficient binding region:25-300	4	4	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P16104	uniprotkb:P61769-PRO_0000018779	intact:EBI-494830|uniprotkb:Q4ZGJ7|uniprotkb:Q6IAS5|ensembl:ENSP00000364310|ensembl:ENSP00000434024	intact:EBI-13942645	psi-mi:h2ax_human(display_long)|uniprotkb:H2AX(gene name)|psi-mi:H2AX(display_short)|uniprotkb:H2AFX(gene name synonym)|uniprotkb:Histone H2A.X(gene name synonym)	psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name)	psi-mi:"MI:0114"(x-ray crystallography)	Shiroishi et al. (2006)	pubmed:16455647|imex:IM-26251	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-15485613|imex:IM-26251-9|wwpdb:2d31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000188486(gene)|ensembl:ENST00000375167(transcript)|ensembl:ENST00000530167(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000786"(nucleosome)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0001741"(XY body)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|refseq:NP_002096.1|dip:DIP-33604N|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-3214858|reactome:R-HSA-427359|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5334118|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5625886|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-606279|reactome:R-HSA-69473|reactome:R-HSA-73728|reactome:R-HSA-73772|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9670095|reactome:R-HSA-9710421|reactome:R-HSA-977225|go:"GO:0005813"(centrosome)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006342"|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042393"(histone binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0090398"(cellular senescence)|go:"GO:0090734"(site of DNA damage)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P16104|rcsb pdb:1YDP|rcsb pdb:2AZM|rcsb pdb:2D31|rcsb pdb:2DYP|rcsb pdb:3SHV|rcsb pdb:3SQD|rcsb pdb:3SZM|rcsb pdb:3U3Z|rcsb pdb:6K1I|rcsb pdb:6K1J|rcsb pdb:6K1K	intact:EBI-714718(chain-parent)	-	-	chain-seq-start:21|chain-seq-end:119	figure legend:Table 1|3d-resolution:3.2 A|3d-r-factors:RFree = 0.298  RWork = 0.235|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/06/01	2017/07/24	rogid:VQoEp3F8lEBTOj+PDDUzrJCQNZA9606	rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606	rigid:hXEw5iprKjbH0eD4Tn4hqIBJZfk	false	sufficient binding region:78-86	-	4	4	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8NHL6	uniprotkb:P16104	intact:EBI-2805262|uniprotkb:Q8NHK0|uniprotkb:Q8NHJ9|uniprotkb:O75025|uniprotkb:O75024|uniprotkb:A8MXT0|ensembl:ENSP00000480365|ensembl:ENSP00000481700|uniprotkb:A2IXV4	intact:EBI-494830|uniprotkb:Q4ZGJ7|uniprotkb:Q6IAS5|ensembl:ENSP00000364310|ensembl:ENSP00000434024	psi-mi:lirb1_human(display_long)|uniprotkb:ILT2(gene name synonym)|uniprotkb:LIR1(gene name synonym)|uniprotkb:MIR7(gene name synonym)|uniprotkb:CD85 antigen-like family member J(gene name synonym)|uniprotkb:Immunoglobulin-like transcript 2(gene name synonym)|uniprotkb:Monocyte/macrophage immunoglobulin-like receptor 7(gene name synonym)|uniprotkb:LILRB1(gene name)|psi-mi:LILRB1(display_short)	psi-mi:h2ax_human(display_long)|uniprotkb:H2AX(gene name)|psi-mi:H2AX(display_short)|uniprotkb:H2AFX(gene name synonym)|uniprotkb:Histone H2A.X(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Shiroishi et al. (2006)	pubmed:16455647|imex:IM-26251	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-15485698|imex:IM-26251-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000274669(gene)|ensembl:ENSG00000277807(gene)|ensembl:ENST00000616408(transcript)|ensembl:ENST00000618055(transcript)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002767"(immune response-inhibiting cell surface receptor signaling pathway)|go:"GO:0002774"(Fc receptor mediated inhibitory signaling pathway)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014063"(negative regulation of serotonin secretion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023025"(MHC class Ib protein complex binding)|go:"GO:0023029"(MHC class Ib protein binding)|go:"GO:0030107"(HLA-A specific inhibitory MHC class I receptor activity)|go:"GO:0030109"(HLA-B specific inhibitory MHC class I receptor activity)|go:"GO:0031623"(receptor internalization)|go:"GO:0032393"(MHC class I receptor activity)|go:"GO:0032394"(MHC class Ib receptor activity)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032945"(negative regulation of mononuclear cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046636"(negative regulation of alpha-beta T cell activation)|go:"GO:0051607"(defense response to virus)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071635"(negative regulation of transforming growth factor beta production)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|go:"GO:2001186"(negative regulation of CD8-positive, alpha-beta T cell activation)|go:"GO:2001189"(negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|go:"GO:2001193"(positive regulation of gamma-delta T cell activation involved in immune response)|go:"GO:2001199"(negative regulation of dendritic cell differentiation)|go:"GO:2001205"(negative regulation of osteoclast development)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:Q8NHL6|rcsb pdb:1G0X|rcsb pdb:1P7Q|rcsb pdb:1UFU|rcsb pdb:1UGN|rcsb pdb:1VDG|rcsb pdb:3D2U|rcsb pdb:4LL9|rcsb pdb:4NO0|rcsb pdb:5KNM|rcsb pdb:6AEE|rcsb pdb:6EWA|rcsb pdb:6EWC|rcsb pdb:6EWO|rcsb pdb:6K60|rcsb pdb:6ZDX|rcsb pdb:7KFK|reactome:R-HSA-198933|go:"GO:0097028"(dendritic cell differentiation)|refseq:NP_001265328.2|refseq:NP_001075106.2|refseq:NP_001075107.2|refseq:NP_001075108.2|refseq:NP_001265327.2|refseq:NP_006660.4	ensembl:ENSG00000188486(gene)|ensembl:ENST00000375167(transcript)|ensembl:ENST00000530167(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000786"(nucleosome)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0001741"(XY body)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|refseq:NP_002096.1|dip:DIP-33604N|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-3214858|reactome:R-HSA-427359|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5334118|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5625886|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-606279|reactome:R-HSA-69473|reactome:R-HSA-73728|reactome:R-HSA-73772|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9670095|reactome:R-HSA-9710421|reactome:R-HSA-977225|go:"GO:0005813"(centrosome)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006342"|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042393"(histone binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0090398"(cellular senescence)|go:"GO:0090734"(site of DNA damage)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P16104|rcsb pdb:1YDP|rcsb pdb:2AZM|rcsb pdb:2D31|rcsb pdb:2DYP|rcsb pdb:3SHV|rcsb pdb:3SQD|rcsb pdb:3SZM|rcsb pdb:3U3Z|rcsb pdb:6K1I|rcsb pdb:6K1J|rcsb pdb:6K1K	-	-	-	figure legend:"2 (A)B/E"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:3.5x10^-6(molar)	2017/06/01	2017/07/24	rogid:c3bdpF4SePNjbOkhewak+Vj98hU9606	rogid:VQoEp3F8lEBTOj+PDDUzrJCQNZA9606	rigid:TSvimsejCtUmAt5KFPAFwVqDWwU	false	biotin tag:c-c|sufficient binding region:24-220..220	sufficient binding region:78-86	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8NHL6	uniprotkb:P17693	intact:EBI-2805262|uniprotkb:Q8NHK0|uniprotkb:Q8NHJ9|uniprotkb:O75025|uniprotkb:O75024|uniprotkb:A8MXT0|ensembl:ENSP00000480365|ensembl:ENSP00000481700|uniprotkb:A2IXV4	intact:EBI-1043063|ensembl:ENSP00000353472|ensembl:ENSP00000388176|ensembl:ENSP00000389522|ensembl:ENSP00000398200|ensembl:ENSP00000373116|ensembl:ENSP00000405238|ensembl:ENSP00000408773|ensembl:ENSP00000412927|ensembl:ENSP00000447762|ensembl:ENSP00000447780|ensembl:ENSP00000448085|ensembl:ENSP00000448363|ensembl:ENSP00000449291|ensembl:ENSP00000449903	psi-mi:lirb1_human(display_long)|uniprotkb:ILT2(gene name synonym)|uniprotkb:LIR1(gene name synonym)|uniprotkb:MIR7(gene name synonym)|uniprotkb:CD85 antigen-like family member J(gene name synonym)|uniprotkb:Immunoglobulin-like transcript 2(gene name synonym)|uniprotkb:Monocyte/macrophage immunoglobulin-like receptor 7(gene name synonym)|uniprotkb:LILRB1(gene name)|psi-mi:LILRB1(display_short)	psi-mi:hlag_human(display_long)|uniprotkb:HLAG(gene name synonym)|uniprotkb:HLA-G(gene name)|psi-mi:HLA-G(display_short)|uniprotkb:HLA-6.0(gene name synonym)|uniprotkb:HLA G antigen(gene name synonym)|uniprotkb:MHC class I antigen G(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Shiroishi et al. (2006)	pubmed:16455647|imex:IM-26251	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-15485698|imex:IM-26251-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000274669(gene)|ensembl:ENSG00000277807(gene)|ensembl:ENST00000616408(transcript)|ensembl:ENST00000618055(transcript)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002767"(immune response-inhibiting cell surface receptor signaling pathway)|go:"GO:0002774"(Fc receptor mediated inhibitory signaling pathway)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014063"(negative regulation of serotonin secretion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023025"(MHC class Ib protein complex binding)|go:"GO:0023029"(MHC class Ib protein binding)|go:"GO:0030107"(HLA-A specific inhibitory MHC class I receptor activity)|go:"GO:0030109"(HLA-B specific inhibitory MHC class I receptor activity)|go:"GO:0031623"(receptor internalization)|go:"GO:0032393"(MHC class I receptor activity)|go:"GO:0032394"(MHC class Ib receptor activity)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032945"(negative regulation of mononuclear cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046636"(negative regulation of alpha-beta T cell activation)|go:"GO:0051607"(defense response to virus)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071635"(negative regulation of transforming growth factor beta production)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|go:"GO:2001186"(negative regulation of CD8-positive, alpha-beta T cell activation)|go:"GO:2001189"(negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|go:"GO:2001193"(positive regulation of gamma-delta T cell activation involved in immune response)|go:"GO:2001199"(negative regulation of dendritic cell differentiation)|go:"GO:2001205"(negative regulation of osteoclast development)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:Q8NHL6|rcsb pdb:1G0X|rcsb pdb:1P7Q|rcsb pdb:1UFU|rcsb pdb:1UGN|rcsb pdb:1VDG|rcsb pdb:3D2U|rcsb pdb:4LL9|rcsb pdb:4NO0|rcsb pdb:5KNM|rcsb pdb:6AEE|rcsb pdb:6EWA|rcsb pdb:6EWC|rcsb pdb:6EWO|rcsb pdb:6K60|rcsb pdb:6ZDX|rcsb pdb:7KFK|reactome:R-HSA-198933|go:"GO:0097028"(dendritic cell differentiation)|refseq:NP_001265328.2|refseq:NP_001075106.2|refseq:NP_001075107.2|refseq:NP_001075108.2|refseq:NP_001265327.2|refseq:NP_006660.4	ensembl:ENSG00000204632(gene)|ensembl:ENSG00000206506(gene)|ensembl:ENSG00000230413(gene)|ensembl:ENSG00000233095(gene)|ensembl:ENSG00000235346(gene)|ensembl:ENSG00000235680(gene)|ensembl:ENSG00000237216(gene)|ensembl:ENST00000360323(transcript)|ensembl:ENST00000383621(transcript)|ensembl:ENST00000423011(transcript)|ensembl:ENST00000423373(transcript)|ensembl:ENST00000428701(transcript)|ensembl:ENST00000428952(transcript)|ensembl:ENST00000444098(transcript)|ensembl:ENST00000449127(transcript)|ensembl:ENST00000546545(transcript)|ensembl:ENST00000546634(transcript)|ensembl:ENST00000547241(transcript)|ensembl:ENST00000547931(transcript)|ensembl:ENST00000550897(transcript)|ensembl:ENST00000553052(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002451"(peripheral B cell tolerance induction)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0002476"(antigen processing and presentation of endogenous peptide antigen via MHC class Ib)|go:"GO:0002645"(positive regulation of tolerance induction)|go:"GO:0002666"(positive regulation of T cell tolerance induction)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0002767"(immune response-inhibiting cell surface receptor signaling pathway)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006968"(cellular defense response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0033106"(cis-Golgi network membrane)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0031527"(filopodium membrane)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0070207"(protein homotrimerization)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000774"(positive regulation of cellular senescence)|go:"GO:2001199"(negative regulation of dendritic cell differentiation)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|mint:P17693|rcsb pdb:1YDP|rcsb pdb:2D31|rcsb pdb:2DYP|rcsb pdb:3BZE|rcsb pdb:3CDG|rcsb pdb:3CII|rcsb pdb:3KYN|rcsb pdb:3KYO|rcsb pdb:6AEE|rcsb pdb:6K60|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|refseq:NP_002118.1|dip:DIP-46121N	-	-	-	figure legend:"2 (A)B/E"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:3.5x10^-6(molar)	2017/06/01	2017/07/24	rogid:c3bdpF4SePNjbOkhewak+Vj98hU9606	rogid:E3xsP+XcQvU64mCe/05DTS9vHQw9606	rigid:TSvimsejCtUmAt5KFPAFwVqDWwU	false	biotin tag:c-c|sufficient binding region:24-220..220	sufficient binding region:25-300	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8NHL6	uniprotkb:P61769-PRO_0000018779	intact:EBI-2805262|uniprotkb:Q8NHK0|uniprotkb:Q8NHJ9|uniprotkb:O75025|uniprotkb:O75024|uniprotkb:A8MXT0|ensembl:ENSP00000480365|ensembl:ENSP00000481700|uniprotkb:A2IXV4	intact:EBI-13942645	psi-mi:lirb1_human(display_long)|uniprotkb:ILT2(gene name synonym)|uniprotkb:LIR1(gene name synonym)|uniprotkb:MIR7(gene name synonym)|uniprotkb:CD85 antigen-like family member J(gene name synonym)|uniprotkb:Immunoglobulin-like transcript 2(gene name synonym)|uniprotkb:Monocyte/macrophage immunoglobulin-like receptor 7(gene name synonym)|uniprotkb:LILRB1(gene name)|psi-mi:LILRB1(display_short)	psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name)	psi-mi:"MI:0107"(surface plasmon resonance)	Shiroishi et al. (2006)	pubmed:16455647|imex:IM-26251	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-15485698|imex:IM-26251-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000274669(gene)|ensembl:ENSG00000277807(gene)|ensembl:ENST00000616408(transcript)|ensembl:ENST00000618055(transcript)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002767"(immune response-inhibiting cell surface receptor signaling pathway)|go:"GO:0002774"(Fc receptor mediated inhibitory signaling pathway)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014063"(negative regulation of serotonin secretion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023025"(MHC class Ib protein complex binding)|go:"GO:0023029"(MHC class Ib protein binding)|go:"GO:0030107"(HLA-A specific inhibitory MHC class I receptor activity)|go:"GO:0030109"(HLA-B specific inhibitory MHC class I receptor activity)|go:"GO:0031623"(receptor internalization)|go:"GO:0032393"(MHC class I receptor activity)|go:"GO:0032394"(MHC class Ib receptor activity)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032945"(negative regulation of mononuclear cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046636"(negative regulation of alpha-beta T cell activation)|go:"GO:0051607"(defense response to virus)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071635"(negative regulation of transforming growth factor beta production)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|go:"GO:2001186"(negative regulation of CD8-positive, alpha-beta T cell activation)|go:"GO:2001189"(negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|go:"GO:2001193"(positive regulation of gamma-delta T cell activation involved in immune response)|go:"GO:2001199"(negative regulation of dendritic cell differentiation)|go:"GO:2001205"(negative regulation of osteoclast development)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:Q8NHL6|rcsb pdb:1G0X|rcsb pdb:1P7Q|rcsb pdb:1UFU|rcsb pdb:1UGN|rcsb pdb:1VDG|rcsb pdb:3D2U|rcsb pdb:4LL9|rcsb pdb:4NO0|rcsb pdb:5KNM|rcsb pdb:6AEE|rcsb pdb:6EWA|rcsb pdb:6EWC|rcsb pdb:6EWO|rcsb pdb:6K60|rcsb pdb:6ZDX|rcsb pdb:7KFK|reactome:R-HSA-198933|go:"GO:0097028"(dendritic cell differentiation)|refseq:NP_001265328.2|refseq:NP_001075106.2|refseq:NP_001075107.2|refseq:NP_001075108.2|refseq:NP_001265327.2|refseq:NP_006660.4	intact:EBI-714718(chain-parent)	-	-	chain-seq-start:21|chain-seq-end:119	figure legend:"2 (A)B/E"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:3.5x10^-6(molar)	2017/06/01	2017/07/24	rogid:c3bdpF4SePNjbOkhewak+Vj98hU9606	rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606	rigid:TSvimsejCtUmAt5KFPAFwVqDWwU	false	biotin tag:c-c|sufficient binding region:24-220..220	sufficient binding region:1-99	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8NHL6	uniprotkb:P16104	intact:EBI-2805262|uniprotkb:Q8NHK0|uniprotkb:Q8NHJ9|uniprotkb:O75025|uniprotkb:O75024|uniprotkb:A8MXT0|ensembl:ENSP00000480365|ensembl:ENSP00000481700|uniprotkb:A2IXV4	intact:EBI-494830|uniprotkb:Q4ZGJ7|uniprotkb:Q6IAS5|ensembl:ENSP00000364310|ensembl:ENSP00000434024	psi-mi:lirb1_human(display_long)|uniprotkb:ILT2(gene name synonym)|uniprotkb:LIR1(gene name synonym)|uniprotkb:MIR7(gene name synonym)|uniprotkb:CD85 antigen-like family member J(gene name synonym)|uniprotkb:Immunoglobulin-like transcript 2(gene name synonym)|uniprotkb:Monocyte/macrophage immunoglobulin-like receptor 7(gene name synonym)|uniprotkb:LILRB1(gene name)|psi-mi:LILRB1(display_short)	psi-mi:h2ax_human(display_long)|uniprotkb:H2AX(gene name)|psi-mi:H2AX(display_short)|uniprotkb:H2AFX(gene name synonym)|uniprotkb:Histone H2A.X(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Shiroishi et al. (2006)	pubmed:16455647|imex:IM-26251	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-15485723|imex:IM-26251-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000274669(gene)|ensembl:ENSG00000277807(gene)|ensembl:ENST00000616408(transcript)|ensembl:ENST00000618055(transcript)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002767"(immune response-inhibiting cell surface receptor signaling pathway)|go:"GO:0002774"(Fc receptor mediated inhibitory signaling pathway)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014063"(negative regulation of serotonin secretion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023025"(MHC class Ib protein complex binding)|go:"GO:0023029"(MHC class Ib protein binding)|go:"GO:0030107"(HLA-A specific inhibitory MHC class I receptor activity)|go:"GO:0030109"(HLA-B specific inhibitory MHC class I receptor activity)|go:"GO:0031623"(receptor internalization)|go:"GO:0032393"(MHC class I receptor activity)|go:"GO:0032394"(MHC class Ib receptor activity)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032945"(negative regulation of mononuclear cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046636"(negative regulation of alpha-beta T cell activation)|go:"GO:0051607"(defense response to virus)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071635"(negative regulation of transforming growth factor beta production)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|go:"GO:2001186"(negative regulation of CD8-positive, alpha-beta T cell activation)|go:"GO:2001189"(negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|go:"GO:2001193"(positive regulation of gamma-delta T cell activation involved in immune response)|go:"GO:2001199"(negative regulation of dendritic cell differentiation)|go:"GO:2001205"(negative regulation of osteoclast development)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:Q8NHL6|rcsb pdb:1G0X|rcsb pdb:1P7Q|rcsb pdb:1UFU|rcsb pdb:1UGN|rcsb pdb:1VDG|rcsb pdb:3D2U|rcsb pdb:4LL9|rcsb pdb:4NO0|rcsb pdb:5KNM|rcsb pdb:6AEE|rcsb pdb:6EWA|rcsb pdb:6EWC|rcsb pdb:6EWO|rcsb pdb:6K60|rcsb pdb:6ZDX|rcsb pdb:7KFK|reactome:R-HSA-198933|go:"GO:0097028"(dendritic cell differentiation)|refseq:NP_001265328.2|refseq:NP_001075106.2|refseq:NP_001075107.2|refseq:NP_001075108.2|refseq:NP_001265327.2|refseq:NP_006660.4	ensembl:ENSG00000188486(gene)|ensembl:ENST00000375167(transcript)|ensembl:ENST00000530167(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000786"(nucleosome)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0001741"(XY body)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|refseq:NP_002096.1|dip:DIP-33604N|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-3214858|reactome:R-HSA-427359|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5334118|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5625886|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-606279|reactome:R-HSA-69473|reactome:R-HSA-73728|reactome:R-HSA-73772|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9670095|reactome:R-HSA-9710421|reactome:R-HSA-977225|go:"GO:0005813"(centrosome)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006342"|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042393"(histone binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0090398"(cellular senescence)|go:"GO:0090734"(site of DNA damage)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P16104|rcsb pdb:1YDP|rcsb pdb:2AZM|rcsb pdb:2D31|rcsb pdb:2DYP|rcsb pdb:3SHV|rcsb pdb:3SQD|rcsb pdb:3SZM|rcsb pdb:3U3Z|rcsb pdb:6K1I|rcsb pdb:6K1J|rcsb pdb:6K1K	-	-	-	figure legend:2 A|comment:"The simple 1:1 (Langmuir) binding model was not successful at high concentrations of the dimer, but was well fitted with a bivalent analyte model. (1:2 (dimer:LILRB) complex )"|kinetics:affinity constant -Kd ∼6.7 nm for LILRB1, at low concentrations of dimer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/06/01	2017/07/24	rogid:c3bdpF4SePNjbOkhewak+Vj98hU9606	rogid:VQoEp3F8lEBTOj+PDDUzrJCQNZA9606	rigid:TSvimsejCtUmAt5KFPAFwVqDWwU	false	biotin tag:c-c|sufficient binding region:24-220..220	sufficient binding region:78-86	2	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8NHL6	uniprotkb:P17693	intact:EBI-2805262|uniprotkb:Q8NHK0|uniprotkb:Q8NHJ9|uniprotkb:O75025|uniprotkb:O75024|uniprotkb:A8MXT0|ensembl:ENSP00000480365|ensembl:ENSP00000481700|uniprotkb:A2IXV4	intact:EBI-1043063|ensembl:ENSP00000353472|ensembl:ENSP00000388176|ensembl:ENSP00000389522|ensembl:ENSP00000398200|ensembl:ENSP00000373116|ensembl:ENSP00000405238|ensembl:ENSP00000408773|ensembl:ENSP00000412927|ensembl:ENSP00000447762|ensembl:ENSP00000447780|ensembl:ENSP00000448085|ensembl:ENSP00000448363|ensembl:ENSP00000449291|ensembl:ENSP00000449903	psi-mi:lirb1_human(display_long)|uniprotkb:ILT2(gene name synonym)|uniprotkb:LIR1(gene name synonym)|uniprotkb:MIR7(gene name synonym)|uniprotkb:CD85 antigen-like family member J(gene name synonym)|uniprotkb:Immunoglobulin-like transcript 2(gene name synonym)|uniprotkb:Monocyte/macrophage immunoglobulin-like receptor 7(gene name synonym)|uniprotkb:LILRB1(gene name)|psi-mi:LILRB1(display_short)	psi-mi:hlag_human(display_long)|uniprotkb:HLAG(gene name synonym)|uniprotkb:HLA-G(gene name)|psi-mi:HLA-G(display_short)|uniprotkb:HLA-6.0(gene name synonym)|uniprotkb:HLA G antigen(gene name synonym)|uniprotkb:MHC class I antigen G(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Shiroishi et al. (2006)	pubmed:16455647|imex:IM-26251	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-15485723|imex:IM-26251-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000274669(gene)|ensembl:ENSG00000277807(gene)|ensembl:ENST00000616408(transcript)|ensembl:ENST00000618055(transcript)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002767"(immune response-inhibiting cell surface receptor signaling pathway)|go:"GO:0002774"(Fc receptor mediated inhibitory signaling pathway)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014063"(negative regulation of serotonin secretion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023025"(MHC class Ib protein complex binding)|go:"GO:0023029"(MHC class Ib protein binding)|go:"GO:0030107"(HLA-A specific inhibitory MHC class I receptor activity)|go:"GO:0030109"(HLA-B specific inhibitory MHC class I receptor activity)|go:"GO:0031623"(receptor internalization)|go:"GO:0032393"(MHC class I receptor activity)|go:"GO:0032394"(MHC class Ib receptor activity)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032945"(negative regulation of mononuclear cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046636"(negative regulation of alpha-beta T cell activation)|go:"GO:0051607"(defense response to virus)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071635"(negative regulation of transforming growth factor beta production)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|go:"GO:2001186"(negative regulation of CD8-positive, alpha-beta T cell activation)|go:"GO:2001189"(negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|go:"GO:2001193"(positive regulation of gamma-delta T cell activation involved in immune response)|go:"GO:2001199"(negative regulation of dendritic cell differentiation)|go:"GO:2001205"(negative regulation of osteoclast development)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:Q8NHL6|rcsb pdb:1G0X|rcsb pdb:1P7Q|rcsb pdb:1UFU|rcsb pdb:1UGN|rcsb pdb:1VDG|rcsb pdb:3D2U|rcsb pdb:4LL9|rcsb pdb:4NO0|rcsb pdb:5KNM|rcsb pdb:6AEE|rcsb pdb:6EWA|rcsb pdb:6EWC|rcsb pdb:6EWO|rcsb pdb:6K60|rcsb pdb:6ZDX|rcsb pdb:7KFK|reactome:R-HSA-198933|go:"GO:0097028"(dendritic cell differentiation)|refseq:NP_001265328.2|refseq:NP_001075106.2|refseq:NP_001075107.2|refseq:NP_001075108.2|refseq:NP_001265327.2|refseq:NP_006660.4	ensembl:ENSG00000204632(gene)|ensembl:ENSG00000206506(gene)|ensembl:ENSG00000230413(gene)|ensembl:ENSG00000233095(gene)|ensembl:ENSG00000235346(gene)|ensembl:ENSG00000235680(gene)|ensembl:ENSG00000237216(gene)|ensembl:ENST00000360323(transcript)|ensembl:ENST00000383621(transcript)|ensembl:ENST00000423011(transcript)|ensembl:ENST00000423373(transcript)|ensembl:ENST00000428701(transcript)|ensembl:ENST00000428952(transcript)|ensembl:ENST00000444098(transcript)|ensembl:ENST00000449127(transcript)|ensembl:ENST00000546545(transcript)|ensembl:ENST00000546634(transcript)|ensembl:ENST00000547241(transcript)|ensembl:ENST00000547931(transcript)|ensembl:ENST00000550897(transcript)|ensembl:ENST00000553052(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002451"(peripheral B cell tolerance induction)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0002476"(antigen processing and presentation of endogenous peptide antigen via MHC class Ib)|go:"GO:0002645"(positive regulation of tolerance induction)|go:"GO:0002666"(positive regulation of T cell tolerance induction)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0002767"(immune response-inhibiting cell surface receptor signaling pathway)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006968"(cellular defense response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0033106"(cis-Golgi network membrane)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0031527"(filopodium membrane)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0070207"(protein homotrimerization)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000774"(positive regulation of cellular senescence)|go:"GO:2001199"(negative regulation of dendritic cell differentiation)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|mint:P17693|rcsb pdb:1YDP|rcsb pdb:2D31|rcsb pdb:2DYP|rcsb pdb:3BZE|rcsb pdb:3CDG|rcsb pdb:3CII|rcsb pdb:3KYN|rcsb pdb:3KYO|rcsb pdb:6AEE|rcsb pdb:6K60|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|refseq:NP_002118.1|dip:DIP-46121N	-	-	-	figure legend:2 A|comment:"The simple 1:1 (Langmuir) binding model was not successful at high concentrations of the dimer, but was well fitted with a bivalent analyte model. (1:2 (dimer:LILRB) complex )"|kinetics:affinity constant -Kd ∼6.7 nm for LILRB1, at low concentrations of dimer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/06/01	2017/07/24	rogid:c3bdpF4SePNjbOkhewak+Vj98hU9606	rogid:E3xsP+XcQvU64mCe/05DTS9vHQw9606	rigid:TSvimsejCtUmAt5KFPAFwVqDWwU	false	biotin tag:c-c|sufficient binding region:24-220..220	sufficient binding region:25-300	2	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8NHL6	uniprotkb:P61769-PRO_0000018779	intact:EBI-2805262|uniprotkb:Q8NHK0|uniprotkb:Q8NHJ9|uniprotkb:O75025|uniprotkb:O75024|uniprotkb:A8MXT0|ensembl:ENSP00000480365|ensembl:ENSP00000481700|uniprotkb:A2IXV4	intact:EBI-13942645	psi-mi:lirb1_human(display_long)|uniprotkb:ILT2(gene name synonym)|uniprotkb:LIR1(gene name synonym)|uniprotkb:MIR7(gene name synonym)|uniprotkb:CD85 antigen-like family member J(gene name synonym)|uniprotkb:Immunoglobulin-like transcript 2(gene name synonym)|uniprotkb:Monocyte/macrophage immunoglobulin-like receptor 7(gene name synonym)|uniprotkb:LILRB1(gene name)|psi-mi:LILRB1(display_short)	psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name)	psi-mi:"MI:0107"(surface plasmon resonance)	Shiroishi et al. (2006)	pubmed:16455647|imex:IM-26251	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-15485723|imex:IM-26251-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000274669(gene)|ensembl:ENSG00000277807(gene)|ensembl:ENST00000616408(transcript)|ensembl:ENST00000618055(transcript)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002767"(immune response-inhibiting cell surface receptor signaling pathway)|go:"GO:0002774"(Fc receptor mediated inhibitory signaling pathway)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014063"(negative regulation of serotonin secretion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023025"(MHC class Ib protein complex binding)|go:"GO:0023029"(MHC class Ib protein binding)|go:"GO:0030107"(HLA-A specific inhibitory MHC class I receptor activity)|go:"GO:0030109"(HLA-B specific inhibitory MHC class I receptor activity)|go:"GO:0031623"(receptor internalization)|go:"GO:0032393"(MHC class I receptor activity)|go:"GO:0032394"(MHC class Ib receptor activity)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032945"(negative regulation of mononuclear cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046636"(negative regulation of alpha-beta T cell activation)|go:"GO:0051607"(defense response to virus)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071635"(negative regulation of transforming growth factor beta production)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|go:"GO:2001186"(negative regulation of CD8-positive, alpha-beta T cell activation)|go:"GO:2001189"(negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|go:"GO:2001193"(positive regulation of gamma-delta T cell activation involved in immune response)|go:"GO:2001199"(negative regulation of dendritic cell differentiation)|go:"GO:2001205"(negative regulation of osteoclast development)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:Q8NHL6|rcsb pdb:1G0X|rcsb pdb:1P7Q|rcsb pdb:1UFU|rcsb pdb:1UGN|rcsb pdb:1VDG|rcsb pdb:3D2U|rcsb pdb:4LL9|rcsb pdb:4NO0|rcsb pdb:5KNM|rcsb pdb:6AEE|rcsb pdb:6EWA|rcsb pdb:6EWC|rcsb pdb:6EWO|rcsb pdb:6K60|rcsb pdb:6ZDX|rcsb pdb:7KFK|reactome:R-HSA-198933|go:"GO:0097028"(dendritic cell differentiation)|refseq:NP_001265328.2|refseq:NP_001075106.2|refseq:NP_001075107.2|refseq:NP_001075108.2|refseq:NP_001265327.2|refseq:NP_006660.4	intact:EBI-714718(chain-parent)	-	-	chain-seq-start:21|chain-seq-end:119	figure legend:2 A|comment:"The simple 1:1 (Langmuir) binding model was not successful at high concentrations of the dimer, but was well fitted with a bivalent analyte model. (1:2 (dimer:LILRB) complex )"|kinetics:affinity constant -Kd ∼6.7 nm for LILRB1, at low concentrations of dimer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/06/01	2017/07/24	rogid:c3bdpF4SePNjbOkhewak+Vj98hU9606	rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606	rigid:TSvimsejCtUmAt5KFPAFwVqDWwU	false	biotin tag:c-c|sufficient binding region:24-220..220	sufficient binding region:1-99	2	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8N423	uniprotkb:P16104	intact:EBI-2816428|uniprotkb:Q8NHJ7|uniprotkb:Q8NHJ8|uniprotkb:O75017|uniprotkb:A8MU67|uniprotkb:C9JF29|ensembl:ENSP00000319960|ensembl:ENSP00000375626|ensembl:ENSP00000375628|ensembl:ENSP00000375629|ensembl:ENSP00000410117|ensembl:ENSP00000480302|ensembl:ENSP00000481208|ensembl:ENSP00000482933|ensembl:ENSP00000483553|ensembl:ENSP00000484373	intact:EBI-494830|uniprotkb:Q4ZGJ7|uniprotkb:Q6IAS5|ensembl:ENSP00000364310|ensembl:ENSP00000434024	psi-mi:lirb2_human(display_long)|uniprotkb:LILRB2(gene name)|psi-mi:LILRB2(display_short)|uniprotkb:ILT4(gene name synonym)|uniprotkb:LIR2(gene name synonym)|uniprotkb:MIR10(gene name synonym)|uniprotkb:CD85 antigen-like family member D(gene name synonym)|uniprotkb:Immunoglobulin-like transcript 4(gene name synonym)|uniprotkb:Monocyte/macrophage immunoglobulin-like receptor 10(gene name synonym)	psi-mi:h2ax_human(display_long)|uniprotkb:H2AX(gene name)|psi-mi:H2AX(display_short)|uniprotkb:H2AFX(gene name synonym)|uniprotkb:Histone H2A.X(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Shiroishi et al. (2006)	pubmed:16455647|imex:IM-26251	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-15485747|imex:IM-26251-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-59888N|ensembl:ENSG00000131042(gene)|ensembl:ENSG00000274513(gene)|ensembl:ENSG00000275463(gene)|ensembl:ENSG00000276146(gene)|ensembl:ENST00000314446(transcript)|ensembl:ENST00000391746(transcript)|ensembl:ENST00000391748(transcript)|ensembl:ENST00000391749(transcript)|ensembl:ENST00000434421(transcript)|ensembl:ENST00000610886(transcript)|ensembl:ENST00000617341(transcript)|ensembl:ENST00000617886(transcript)|ensembl:ENST00000618392(transcript)|ensembl:ENST00000618705(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002578"(negative regulation of antigen processing and presentation)|go:"GO:0002645"(positive regulation of tolerance induction)|go:"GO:0002666"(positive regulation of T cell tolerance induction)|go:"GO:0002767"(immune response-inhibiting cell surface receptor signaling pathway)|go:"GO:0002774"(Fc receptor mediated inhibitory signaling pathway)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007611"(learning or memory)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0023025"(MHC class Ib protein complex binding)|go:"GO:0023029"(MHC class Ib protein binding)|go:"GO:0032396"(inhibitory MHC class I receptor activity)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:0140105"(interleukin-10-mediated signaling pathway)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1905875"(negative regulation of postsynaptic density organization)|go:"GO:2000524"(negative regulation of T cell costimulation)|go:"GO:2001198"(regulation of dendritic cell differentiation)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2DYP|rcsb pdb:2GW5|rcsb pdb:4LLA|rcsb pdb:6AED|rcsb pdb:6BCS|reactome:R-HSA-198933|reactome:R-HSA-6798695	ensembl:ENSG00000188486(gene)|ensembl:ENST00000375167(transcript)|ensembl:ENST00000530167(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000786"(nucleosome)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0001741"(XY body)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|refseq:NP_002096.1|dip:DIP-33604N|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-3214858|reactome:R-HSA-427359|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5334118|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5625886|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-606279|reactome:R-HSA-69473|reactome:R-HSA-73728|reactome:R-HSA-73772|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9670095|reactome:R-HSA-9710421|reactome:R-HSA-977225|go:"GO:0005813"(centrosome)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006342"|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042393"(histone binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0090398"(cellular senescence)|go:"GO:0090734"(site of DNA damage)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P16104|rcsb pdb:1YDP|rcsb pdb:2AZM|rcsb pdb:2D31|rcsb pdb:2DYP|rcsb pdb:3SHV|rcsb pdb:3SQD|rcsb pdb:3SZM|rcsb pdb:3U3Z|rcsb pdb:6K1I|rcsb pdb:6K1J|rcsb pdb:6K1K	-	-	-	figure legend:2 C|comment:"The simple 1:1 (Langmuir) binding model was not successful at high concentrations of the dimer, but was well fitted with a bivalent analyte model. (1:2 (dimer:LILRB) complex )"|kinetics:affinity constant -Kd ∼750 nm for LILRB2, at low concentrations of dimer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/06/01	2017/07/24	rogid:nFaZ5NEqw5u/3Du7Mi6fJpEQEdo9606	rogid:VQoEp3F8lEBTOj+PDDUzrJCQNZA9606	rigid:2gds+HZnweS0A+xafr7u8+xG2NY	false	biotin tag:c-c|sufficient binding region:24-221..221	sufficient binding region:78-86	2	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8N423	uniprotkb:P17693	intact:EBI-2816428|uniprotkb:Q8NHJ7|uniprotkb:Q8NHJ8|uniprotkb:O75017|uniprotkb:A8MU67|uniprotkb:C9JF29|ensembl:ENSP00000319960|ensembl:ENSP00000375626|ensembl:ENSP00000375628|ensembl:ENSP00000375629|ensembl:ENSP00000410117|ensembl:ENSP00000480302|ensembl:ENSP00000481208|ensembl:ENSP00000482933|ensembl:ENSP00000483553|ensembl:ENSP00000484373	intact:EBI-1043063|ensembl:ENSP00000353472|ensembl:ENSP00000388176|ensembl:ENSP00000389522|ensembl:ENSP00000398200|ensembl:ENSP00000373116|ensembl:ENSP00000405238|ensembl:ENSP00000408773|ensembl:ENSP00000412927|ensembl:ENSP00000447762|ensembl:ENSP00000447780|ensembl:ENSP00000448085|ensembl:ENSP00000448363|ensembl:ENSP00000449291|ensembl:ENSP00000449903	psi-mi:lirb2_human(display_long)|uniprotkb:LILRB2(gene name)|psi-mi:LILRB2(display_short)|uniprotkb:ILT4(gene name synonym)|uniprotkb:LIR2(gene name synonym)|uniprotkb:MIR10(gene name synonym)|uniprotkb:CD85 antigen-like family member D(gene name synonym)|uniprotkb:Immunoglobulin-like transcript 4(gene name synonym)|uniprotkb:Monocyte/macrophage immunoglobulin-like receptor 10(gene name synonym)	psi-mi:hlag_human(display_long)|uniprotkb:HLAG(gene name synonym)|uniprotkb:HLA-G(gene name)|psi-mi:HLA-G(display_short)|uniprotkb:HLA-6.0(gene name synonym)|uniprotkb:HLA G antigen(gene name synonym)|uniprotkb:MHC class I antigen G(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Shiroishi et al. (2006)	pubmed:16455647|imex:IM-26251	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-15485747|imex:IM-26251-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-59888N|ensembl:ENSG00000131042(gene)|ensembl:ENSG00000274513(gene)|ensembl:ENSG00000275463(gene)|ensembl:ENSG00000276146(gene)|ensembl:ENST00000314446(transcript)|ensembl:ENST00000391746(transcript)|ensembl:ENST00000391748(transcript)|ensembl:ENST00000391749(transcript)|ensembl:ENST00000434421(transcript)|ensembl:ENST00000610886(transcript)|ensembl:ENST00000617341(transcript)|ensembl:ENST00000617886(transcript)|ensembl:ENST00000618392(transcript)|ensembl:ENST00000618705(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002578"(negative regulation of antigen processing and presentation)|go:"GO:0002645"(positive regulation of tolerance induction)|go:"GO:0002666"(positive regulation of T cell tolerance induction)|go:"GO:0002767"(immune response-inhibiting cell surface receptor signaling pathway)|go:"GO:0002774"(Fc receptor mediated inhibitory signaling pathway)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007611"(learning or memory)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0023025"(MHC class Ib protein complex binding)|go:"GO:0023029"(MHC class Ib protein binding)|go:"GO:0032396"(inhibitory MHC class I receptor activity)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:0140105"(interleukin-10-mediated signaling pathway)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1905875"(negative regulation of postsynaptic density organization)|go:"GO:2000524"(negative regulation of T cell costimulation)|go:"GO:2001198"(regulation of dendritic cell differentiation)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2DYP|rcsb pdb:2GW5|rcsb pdb:4LLA|rcsb pdb:6AED|rcsb pdb:6BCS|reactome:R-HSA-198933|reactome:R-HSA-6798695	ensembl:ENSG00000204632(gene)|ensembl:ENSG00000206506(gene)|ensembl:ENSG00000230413(gene)|ensembl:ENSG00000233095(gene)|ensembl:ENSG00000235346(gene)|ensembl:ENSG00000235680(gene)|ensembl:ENSG00000237216(gene)|ensembl:ENST00000360323(transcript)|ensembl:ENST00000383621(transcript)|ensembl:ENST00000423011(transcript)|ensembl:ENST00000423373(transcript)|ensembl:ENST00000428701(transcript)|ensembl:ENST00000428952(transcript)|ensembl:ENST00000444098(transcript)|ensembl:ENST00000449127(transcript)|ensembl:ENST00000546545(transcript)|ensembl:ENST00000546634(transcript)|ensembl:ENST00000547241(transcript)|ensembl:ENST00000547931(transcript)|ensembl:ENST00000550897(transcript)|ensembl:ENST00000553052(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002451"(peripheral B cell tolerance induction)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0002476"(antigen processing and presentation of endogenous peptide antigen via MHC class Ib)|go:"GO:0002645"(positive regulation of tolerance induction)|go:"GO:0002666"(positive regulation of T cell tolerance induction)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0002767"(immune response-inhibiting cell surface receptor signaling pathway)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006968"(cellular defense response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0033106"(cis-Golgi network membrane)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0031527"(filopodium membrane)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0070207"(protein homotrimerization)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000774"(positive regulation of cellular senescence)|go:"GO:2001199"(negative regulation of dendritic cell differentiation)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|mint:P17693|rcsb pdb:1YDP|rcsb pdb:2D31|rcsb pdb:2DYP|rcsb pdb:3BZE|rcsb pdb:3CDG|rcsb pdb:3CII|rcsb pdb:3KYN|rcsb pdb:3KYO|rcsb pdb:6AEE|rcsb pdb:6K60|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|refseq:NP_002118.1|dip:DIP-46121N	-	-	-	figure legend:2 C|comment:"The simple 1:1 (Langmuir) binding model was not successful at high concentrations of the dimer, but was well fitted with a bivalent analyte model. (1:2 (dimer:LILRB) complex )"|kinetics:affinity constant -Kd ∼750 nm for LILRB2, at low concentrations of dimer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/06/01	2017/07/24	rogid:nFaZ5NEqw5u/3Du7Mi6fJpEQEdo9606	rogid:E3xsP+XcQvU64mCe/05DTS9vHQw9606	rigid:2gds+HZnweS0A+xafr7u8+xG2NY	false	biotin tag:c-c|sufficient binding region:24-221..221	sufficient binding region:25-300	2	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8N423	uniprotkb:P61769-PRO_0000018779	intact:EBI-2816428|uniprotkb:Q8NHJ7|uniprotkb:Q8NHJ8|uniprotkb:O75017|uniprotkb:A8MU67|uniprotkb:C9JF29|ensembl:ENSP00000319960|ensembl:ENSP00000375626|ensembl:ENSP00000375628|ensembl:ENSP00000375629|ensembl:ENSP00000410117|ensembl:ENSP00000480302|ensembl:ENSP00000481208|ensembl:ENSP00000482933|ensembl:ENSP00000483553|ensembl:ENSP00000484373	intact:EBI-13942645	psi-mi:lirb2_human(display_long)|uniprotkb:LILRB2(gene name)|psi-mi:LILRB2(display_short)|uniprotkb:ILT4(gene name synonym)|uniprotkb:LIR2(gene name synonym)|uniprotkb:MIR10(gene name synonym)|uniprotkb:CD85 antigen-like family member D(gene name synonym)|uniprotkb:Immunoglobulin-like transcript 4(gene name synonym)|uniprotkb:Monocyte/macrophage immunoglobulin-like receptor 10(gene name synonym)	psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name)	psi-mi:"MI:0107"(surface plasmon resonance)	Shiroishi et al. (2006)	pubmed:16455647|imex:IM-26251	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-15485747|imex:IM-26251-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-59888N|ensembl:ENSG00000131042(gene)|ensembl:ENSG00000274513(gene)|ensembl:ENSG00000275463(gene)|ensembl:ENSG00000276146(gene)|ensembl:ENST00000314446(transcript)|ensembl:ENST00000391746(transcript)|ensembl:ENST00000391748(transcript)|ensembl:ENST00000391749(transcript)|ensembl:ENST00000434421(transcript)|ensembl:ENST00000610886(transcript)|ensembl:ENST00000617341(transcript)|ensembl:ENST00000617886(transcript)|ensembl:ENST00000618392(transcript)|ensembl:ENST00000618705(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002578"(negative regulation of antigen processing and presentation)|go:"GO:0002645"(positive regulation of tolerance induction)|go:"GO:0002666"(positive regulation of T cell tolerance induction)|go:"GO:0002767"(immune response-inhibiting cell surface receptor signaling pathway)|go:"GO:0002774"(Fc receptor mediated inhibitory signaling pathway)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007611"(learning or memory)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0023025"(MHC class Ib protein complex binding)|go:"GO:0023029"(MHC class Ib protein binding)|go:"GO:0032396"(inhibitory MHC class I receptor activity)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:0140105"(interleukin-10-mediated signaling pathway)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1905875"(negative regulation of postsynaptic density organization)|go:"GO:2000524"(negative regulation of T cell costimulation)|go:"GO:2001198"(regulation of dendritic cell differentiation)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2DYP|rcsb pdb:2GW5|rcsb pdb:4LLA|rcsb pdb:6AED|rcsb pdb:6BCS|reactome:R-HSA-198933|reactome:R-HSA-6798695	intact:EBI-714718(chain-parent)	-	-	chain-seq-start:21|chain-seq-end:119	figure legend:2 C|comment:"The simple 1:1 (Langmuir) binding model was not successful at high concentrations of the dimer, but was well fitted with a bivalent analyte model. (1:2 (dimer:LILRB) complex )"|kinetics:affinity constant -Kd ∼750 nm for LILRB2, at low concentrations of dimer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/06/01	2017/07/24	rogid:nFaZ5NEqw5u/3Du7Mi6fJpEQEdo9606	rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606	rigid:2gds+HZnweS0A+xafr7u8+xG2NY	false	biotin tag:c-c|sufficient binding region:24-221..221	sufficient binding region:1-99	2	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8N423	uniprotkb:P16104	intact:EBI-2816428|uniprotkb:Q8NHJ7|uniprotkb:Q8NHJ8|uniprotkb:O75017|uniprotkb:A8MU67|uniprotkb:C9JF29|ensembl:ENSP00000319960|ensembl:ENSP00000375626|ensembl:ENSP00000375628|ensembl:ENSP00000375629|ensembl:ENSP00000410117|ensembl:ENSP00000480302|ensembl:ENSP00000481208|ensembl:ENSP00000482933|ensembl:ENSP00000483553|ensembl:ENSP00000484373	intact:EBI-494830|uniprotkb:Q4ZGJ7|uniprotkb:Q6IAS5|ensembl:ENSP00000364310|ensembl:ENSP00000434024	psi-mi:lirb2_human(display_long)|uniprotkb:LILRB2(gene name)|psi-mi:LILRB2(display_short)|uniprotkb:ILT4(gene name synonym)|uniprotkb:LIR2(gene name synonym)|uniprotkb:MIR10(gene name synonym)|uniprotkb:CD85 antigen-like family member D(gene name synonym)|uniprotkb:Immunoglobulin-like transcript 4(gene name synonym)|uniprotkb:Monocyte/macrophage immunoglobulin-like receptor 10(gene name synonym)	psi-mi:h2ax_human(display_long)|uniprotkb:H2AX(gene name)|psi-mi:H2AX(display_short)|uniprotkb:H2AFX(gene name synonym)|uniprotkb:Histone H2A.X(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Shiroishi et al. (2006)	pubmed:16455647|imex:IM-26251	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-15485765|imex:IM-26251-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-59888N|ensembl:ENSG00000131042(gene)|ensembl:ENSG00000274513(gene)|ensembl:ENSG00000275463(gene)|ensembl:ENSG00000276146(gene)|ensembl:ENST00000314446(transcript)|ensembl:ENST00000391746(transcript)|ensembl:ENST00000391748(transcript)|ensembl:ENST00000391749(transcript)|ensembl:ENST00000434421(transcript)|ensembl:ENST00000610886(transcript)|ensembl:ENST00000617341(transcript)|ensembl:ENST00000617886(transcript)|ensembl:ENST00000618392(transcript)|ensembl:ENST00000618705(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002578"(negative regulation of antigen processing and presentation)|go:"GO:0002645"(positive regulation of tolerance induction)|go:"GO:0002666"(positive regulation of T cell tolerance induction)|go:"GO:0002767"(immune response-inhibiting cell surface receptor signaling pathway)|go:"GO:0002774"(Fc receptor mediated inhibitory signaling pathway)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007611"(learning or memory)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0023025"(MHC class Ib protein complex binding)|go:"GO:0023029"(MHC class Ib protein binding)|go:"GO:0032396"(inhibitory MHC class I receptor activity)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:0140105"(interleukin-10-mediated signaling pathway)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1905875"(negative regulation of postsynaptic density organization)|go:"GO:2000524"(negative regulation of T cell costimulation)|go:"GO:2001198"(regulation of dendritic cell differentiation)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2DYP|rcsb pdb:2GW5|rcsb pdb:4LLA|rcsb pdb:6AED|rcsb pdb:6BCS|reactome:R-HSA-198933|reactome:R-HSA-6798695	ensembl:ENSG00000188486(gene)|ensembl:ENST00000375167(transcript)|ensembl:ENST00000530167(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000786"(nucleosome)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0001741"(XY body)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|refseq:NP_002096.1|dip:DIP-33604N|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-3214858|reactome:R-HSA-427359|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5334118|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5625886|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-606279|reactome:R-HSA-69473|reactome:R-HSA-73728|reactome:R-HSA-73772|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9670095|reactome:R-HSA-9710421|reactome:R-HSA-977225|go:"GO:0005813"(centrosome)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006342"|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042393"(histone binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0090398"(cellular senescence)|go:"GO:0090734"(site of DNA damage)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P16104|rcsb pdb:1YDP|rcsb pdb:2AZM|rcsb pdb:2D31|rcsb pdb:2DYP|rcsb pdb:3SHV|rcsb pdb:3SQD|rcsb pdb:3SZM|rcsb pdb:3U3Z|rcsb pdb:6K1I|rcsb pdb:6K1J|rcsb pdb:6K1K	-	-	-	figure legend:"2 (C)/D/E"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:15.0x10^-6(molar)	2017/06/01	2017/07/24	rogid:nFaZ5NEqw5u/3Du7Mi6fJpEQEdo9606	rogid:VQoEp3F8lEBTOj+PDDUzrJCQNZA9606	rigid:2gds+HZnweS0A+xafr7u8+xG2NY	false	biotin tag:c-c|sufficient binding region:24-221..221	sufficient binding region:78-86	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8N423	uniprotkb:P17693	intact:EBI-2816428|uniprotkb:Q8NHJ7|uniprotkb:Q8NHJ8|uniprotkb:O75017|uniprotkb:A8MU67|uniprotkb:C9JF29|ensembl:ENSP00000319960|ensembl:ENSP00000375626|ensembl:ENSP00000375628|ensembl:ENSP00000375629|ensembl:ENSP00000410117|ensembl:ENSP00000480302|ensembl:ENSP00000481208|ensembl:ENSP00000482933|ensembl:ENSP00000483553|ensembl:ENSP00000484373	intact:EBI-1043063|ensembl:ENSP00000353472|ensembl:ENSP00000388176|ensembl:ENSP00000389522|ensembl:ENSP00000398200|ensembl:ENSP00000373116|ensembl:ENSP00000405238|ensembl:ENSP00000408773|ensembl:ENSP00000412927|ensembl:ENSP00000447762|ensembl:ENSP00000447780|ensembl:ENSP00000448085|ensembl:ENSP00000448363|ensembl:ENSP00000449291|ensembl:ENSP00000449903	psi-mi:lirb2_human(display_long)|uniprotkb:LILRB2(gene name)|psi-mi:LILRB2(display_short)|uniprotkb:ILT4(gene name synonym)|uniprotkb:LIR2(gene name synonym)|uniprotkb:MIR10(gene name synonym)|uniprotkb:CD85 antigen-like family member D(gene name synonym)|uniprotkb:Immunoglobulin-like transcript 4(gene name synonym)|uniprotkb:Monocyte/macrophage immunoglobulin-like receptor 10(gene name synonym)	psi-mi:hlag_human(display_long)|uniprotkb:HLAG(gene name synonym)|uniprotkb:HLA-G(gene name)|psi-mi:HLA-G(display_short)|uniprotkb:HLA-6.0(gene name synonym)|uniprotkb:HLA G antigen(gene name synonym)|uniprotkb:MHC class I antigen G(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Shiroishi et al. (2006)	pubmed:16455647|imex:IM-26251	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-15485765|imex:IM-26251-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-59888N|ensembl:ENSG00000131042(gene)|ensembl:ENSG00000274513(gene)|ensembl:ENSG00000275463(gene)|ensembl:ENSG00000276146(gene)|ensembl:ENST00000314446(transcript)|ensembl:ENST00000391746(transcript)|ensembl:ENST00000391748(transcript)|ensembl:ENST00000391749(transcript)|ensembl:ENST00000434421(transcript)|ensembl:ENST00000610886(transcript)|ensembl:ENST00000617341(transcript)|ensembl:ENST00000617886(transcript)|ensembl:ENST00000618392(transcript)|ensembl:ENST00000618705(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002578"(negative regulation of antigen processing and presentation)|go:"GO:0002645"(positive regulation of tolerance induction)|go:"GO:0002666"(positive regulation of T cell tolerance induction)|go:"GO:0002767"(immune response-inhibiting cell surface receptor signaling pathway)|go:"GO:0002774"(Fc receptor mediated inhibitory signaling pathway)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007611"(learning or memory)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0023025"(MHC class Ib protein complex binding)|go:"GO:0023029"(MHC class Ib protein binding)|go:"GO:0032396"(inhibitory MHC class I receptor activity)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:0140105"(interleukin-10-mediated signaling pathway)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1905875"(negative regulation of postsynaptic density organization)|go:"GO:2000524"(negative regulation of T cell costimulation)|go:"GO:2001198"(regulation of dendritic cell differentiation)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2DYP|rcsb pdb:2GW5|rcsb pdb:4LLA|rcsb pdb:6AED|rcsb pdb:6BCS|reactome:R-HSA-198933|reactome:R-HSA-6798695	ensembl:ENSG00000204632(gene)|ensembl:ENSG00000206506(gene)|ensembl:ENSG00000230413(gene)|ensembl:ENSG00000233095(gene)|ensembl:ENSG00000235346(gene)|ensembl:ENSG00000235680(gene)|ensembl:ENSG00000237216(gene)|ensembl:ENST00000360323(transcript)|ensembl:ENST00000383621(transcript)|ensembl:ENST00000423011(transcript)|ensembl:ENST00000423373(transcript)|ensembl:ENST00000428701(transcript)|ensembl:ENST00000428952(transcript)|ensembl:ENST00000444098(transcript)|ensembl:ENST00000449127(transcript)|ensembl:ENST00000546545(transcript)|ensembl:ENST00000546634(transcript)|ensembl:ENST00000547241(transcript)|ensembl:ENST00000547931(transcript)|ensembl:ENST00000550897(transcript)|ensembl:ENST00000553052(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002451"(peripheral B cell tolerance induction)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0002476"(antigen processing and presentation of endogenous peptide antigen via MHC class Ib)|go:"GO:0002645"(positive regulation of tolerance induction)|go:"GO:0002666"(positive regulation of T cell tolerance induction)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0002767"(immune response-inhibiting cell surface receptor signaling pathway)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006968"(cellular defense response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0033106"(cis-Golgi network membrane)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0031527"(filopodium membrane)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0070207"(protein homotrimerization)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000774"(positive regulation of cellular senescence)|go:"GO:2001199"(negative regulation of dendritic cell differentiation)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|mint:P17693|rcsb pdb:1YDP|rcsb pdb:2D31|rcsb pdb:2DYP|rcsb pdb:3BZE|rcsb pdb:3CDG|rcsb pdb:3CII|rcsb pdb:3KYN|rcsb pdb:3KYO|rcsb pdb:6AEE|rcsb pdb:6K60|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|refseq:NP_002118.1|dip:DIP-46121N	-	-	-	figure legend:"2 (C)/D/E"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:15.0x10^-6(molar)	2017/06/01	2017/07/24	rogid:nFaZ5NEqw5u/3Du7Mi6fJpEQEdo9606	rogid:E3xsP+XcQvU64mCe/05DTS9vHQw9606	rigid:2gds+HZnweS0A+xafr7u8+xG2NY	false	biotin tag:c-c|sufficient binding region:24-221..221	sufficient binding region:25-300	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8N423	uniprotkb:P61769-PRO_0000018779	intact:EBI-2816428|uniprotkb:Q8NHJ7|uniprotkb:Q8NHJ8|uniprotkb:O75017|uniprotkb:A8MU67|uniprotkb:C9JF29|ensembl:ENSP00000319960|ensembl:ENSP00000375626|ensembl:ENSP00000375628|ensembl:ENSP00000375629|ensembl:ENSP00000410117|ensembl:ENSP00000480302|ensembl:ENSP00000481208|ensembl:ENSP00000482933|ensembl:ENSP00000483553|ensembl:ENSP00000484373	intact:EBI-13942645	psi-mi:lirb2_human(display_long)|uniprotkb:LILRB2(gene name)|psi-mi:LILRB2(display_short)|uniprotkb:ILT4(gene name synonym)|uniprotkb:LIR2(gene name synonym)|uniprotkb:MIR10(gene name synonym)|uniprotkb:CD85 antigen-like family member D(gene name synonym)|uniprotkb:Immunoglobulin-like transcript 4(gene name synonym)|uniprotkb:Monocyte/macrophage immunoglobulin-like receptor 10(gene name synonym)	psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name)	psi-mi:"MI:0107"(surface plasmon resonance)	Shiroishi et al. (2006)	pubmed:16455647|imex:IM-26251	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-15485765|imex:IM-26251-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-59888N|ensembl:ENSG00000131042(gene)|ensembl:ENSG00000274513(gene)|ensembl:ENSG00000275463(gene)|ensembl:ENSG00000276146(gene)|ensembl:ENST00000314446(transcript)|ensembl:ENST00000391746(transcript)|ensembl:ENST00000391748(transcript)|ensembl:ENST00000391749(transcript)|ensembl:ENST00000434421(transcript)|ensembl:ENST00000610886(transcript)|ensembl:ENST00000617341(transcript)|ensembl:ENST00000617886(transcript)|ensembl:ENST00000618392(transcript)|ensembl:ENST00000618705(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002578"(negative regulation of antigen processing and presentation)|go:"GO:0002645"(positive regulation of tolerance induction)|go:"GO:0002666"(positive regulation of T cell tolerance induction)|go:"GO:0002767"(immune response-inhibiting cell surface receptor signaling pathway)|go:"GO:0002774"(Fc receptor mediated inhibitory signaling pathway)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007611"(learning or memory)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0023025"(MHC class Ib protein complex binding)|go:"GO:0023029"(MHC class Ib protein binding)|go:"GO:0032396"(inhibitory MHC class I receptor activity)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:0140105"(interleukin-10-mediated signaling pathway)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1905875"(negative regulation of postsynaptic density organization)|go:"GO:2000524"(negative regulation of T cell costimulation)|go:"GO:2001198"(regulation of dendritic cell differentiation)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2DYP|rcsb pdb:2GW5|rcsb pdb:4LLA|rcsb pdb:6AED|rcsb pdb:6BCS|reactome:R-HSA-198933|reactome:R-HSA-6798695	intact:EBI-714718(chain-parent)	-	-	chain-seq-start:21|chain-seq-end:119	figure legend:"2 (C)/D/E"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:15.0x10^-6(molar)	2017/06/01	2017/07/24	rogid:nFaZ5NEqw5u/3Du7Mi6fJpEQEdo9606	rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606	rigid:2gds+HZnweS0A+xafr7u8+xG2NY	false	biotin tag:c-c|sufficient binding region:24-221..221	sufficient binding region:1-99	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P16104	uniprotkb:Q8NHL6	intact:EBI-494830|uniprotkb:Q4ZGJ7|uniprotkb:Q6IAS5|ensembl:ENSP00000364310|ensembl:ENSP00000434024	intact:EBI-2805262|uniprotkb:Q8NHK0|uniprotkb:Q8NHJ9|uniprotkb:O75025|uniprotkb:O75024|uniprotkb:A8MXT0|ensembl:ENSP00000480365|ensembl:ENSP00000481700|uniprotkb:A2IXV4	psi-mi:h2ax_human(display_long)|uniprotkb:H2AX(gene name)|psi-mi:H2AX(display_short)|uniprotkb:H2AFX(gene name synonym)|uniprotkb:Histone H2A.X(gene name synonym)	psi-mi:lirb1_human(display_long)|uniprotkb:ILT2(gene name synonym)|uniprotkb:LIR1(gene name synonym)|uniprotkb:MIR7(gene name synonym)|uniprotkb:CD85 antigen-like family member J(gene name synonym)|uniprotkb:Immunoglobulin-like transcript 2(gene name synonym)|uniprotkb:Monocyte/macrophage immunoglobulin-like receptor 7(gene name synonym)|uniprotkb:LILRB1(gene name)|psi-mi:LILRB1(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	Shiroishi et al. (2006)	pubmed:16455647|imex:IM-26251	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-15485792|imex:IM-26251-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000188486(gene)|ensembl:ENST00000375167(transcript)|ensembl:ENST00000530167(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000786"(nucleosome)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0001741"(XY body)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|refseq:NP_002096.1|dip:DIP-33604N|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-3214858|reactome:R-HSA-427359|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5334118|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5625886|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-606279|reactome:R-HSA-69473|reactome:R-HSA-73728|reactome:R-HSA-73772|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9670095|reactome:R-HSA-9710421|reactome:R-HSA-977225|go:"GO:0005813"(centrosome)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006342"|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042393"(histone binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0090398"(cellular senescence)|go:"GO:0090734"(site of DNA damage)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P16104|rcsb pdb:1YDP|rcsb pdb:2AZM|rcsb pdb:2D31|rcsb pdb:2DYP|rcsb pdb:3SHV|rcsb pdb:3SQD|rcsb pdb:3SZM|rcsb pdb:3U3Z|rcsb pdb:6K1I|rcsb pdb:6K1J|rcsb pdb:6K1K	ensembl:ENSG00000274669(gene)|ensembl:ENSG00000277807(gene)|ensembl:ENST00000616408(transcript)|ensembl:ENST00000618055(transcript)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002767"(immune response-inhibiting cell surface receptor signaling pathway)|go:"GO:0002774"(Fc receptor mediated inhibitory signaling pathway)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014063"(negative regulation of serotonin secretion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023025"(MHC class Ib protein complex binding)|go:"GO:0023029"(MHC class Ib protein binding)|go:"GO:0030107"(HLA-A specific inhibitory MHC class I receptor activity)|go:"GO:0030109"(HLA-B specific inhibitory MHC class I receptor activity)|go:"GO:0031623"(receptor internalization)|go:"GO:0032393"(MHC class I receptor activity)|go:"GO:0032394"(MHC class Ib receptor activity)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032945"(negative regulation of mononuclear cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046636"(negative regulation of alpha-beta T cell activation)|go:"GO:0051607"(defense response to virus)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071635"(negative regulation of transforming growth factor beta production)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|go:"GO:2001186"(negative regulation of CD8-positive, alpha-beta T cell activation)|go:"GO:2001189"(negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|go:"GO:2001193"(positive regulation of gamma-delta T cell activation involved in immune response)|go:"GO:2001199"(negative regulation of dendritic cell differentiation)|go:"GO:2001205"(negative regulation of osteoclast development)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:Q8NHL6|rcsb pdb:1G0X|rcsb pdb:1P7Q|rcsb pdb:1UFU|rcsb pdb:1UGN|rcsb pdb:1VDG|rcsb pdb:3D2U|rcsb pdb:4LL9|rcsb pdb:4NO0|rcsb pdb:5KNM|rcsb pdb:6AEE|rcsb pdb:6EWA|rcsb pdb:6EWC|rcsb pdb:6EWO|rcsb pdb:6K60|rcsb pdb:6ZDX|rcsb pdb:7KFK|reactome:R-HSA-198933|go:"GO:0097028"(dendritic cell differentiation)|refseq:NP_001265328.2|refseq:NP_001075106.2|refseq:NP_001075107.2|refseq:NP_001075108.2|refseq:NP_001265327.2|refseq:NP_006660.4	-	-	-	figure legend:Supp fig 1, Supp. table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:2.1x10^-6(molar)	2017/06/01	2017/07/24	rogid:VQoEp3F8lEBTOj+PDDUzrJCQNZA9606	rogid:c3bdpF4SePNjbOkhewak+Vj98hU9606	rigid:TSvimsejCtUmAt5KFPAFwVqDWwU	false	sufficient binding region:78-86	sufficient binding region:24-220..220	2	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P16104	uniprotkb:P17693	intact:EBI-494830|uniprotkb:Q4ZGJ7|uniprotkb:Q6IAS5|ensembl:ENSP00000364310|ensembl:ENSP00000434024	intact:EBI-1043063|ensembl:ENSP00000353472|ensembl:ENSP00000388176|ensembl:ENSP00000389522|ensembl:ENSP00000398200|ensembl:ENSP00000373116|ensembl:ENSP00000405238|ensembl:ENSP00000408773|ensembl:ENSP00000412927|ensembl:ENSP00000447762|ensembl:ENSP00000447780|ensembl:ENSP00000448085|ensembl:ENSP00000448363|ensembl:ENSP00000449291|ensembl:ENSP00000449903	psi-mi:h2ax_human(display_long)|uniprotkb:H2AX(gene name)|psi-mi:H2AX(display_short)|uniprotkb:H2AFX(gene name synonym)|uniprotkb:Histone H2A.X(gene name synonym)	psi-mi:hlag_human(display_long)|uniprotkb:HLAG(gene name synonym)|uniprotkb:HLA-G(gene name)|psi-mi:HLA-G(display_short)|uniprotkb:HLA-6.0(gene name synonym)|uniprotkb:HLA G antigen(gene name synonym)|uniprotkb:MHC class I antigen G(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Shiroishi et al. (2006)	pubmed:16455647|imex:IM-26251	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-15485792|imex:IM-26251-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000188486(gene)|ensembl:ENST00000375167(transcript)|ensembl:ENST00000530167(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000786"(nucleosome)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0001741"(XY body)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|refseq:NP_002096.1|dip:DIP-33604N|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-3214858|reactome:R-HSA-427359|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5334118|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5625886|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-606279|reactome:R-HSA-69473|reactome:R-HSA-73728|reactome:R-HSA-73772|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9670095|reactome:R-HSA-9710421|reactome:R-HSA-977225|go:"GO:0005813"(centrosome)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006342"|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042393"(histone binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0090398"(cellular senescence)|go:"GO:0090734"(site of DNA damage)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P16104|rcsb pdb:1YDP|rcsb pdb:2AZM|rcsb pdb:2D31|rcsb pdb:2DYP|rcsb pdb:3SHV|rcsb pdb:3SQD|rcsb pdb:3SZM|rcsb pdb:3U3Z|rcsb pdb:6K1I|rcsb pdb:6K1J|rcsb pdb:6K1K	ensembl:ENSG00000204632(gene)|ensembl:ENSG00000206506(gene)|ensembl:ENSG00000230413(gene)|ensembl:ENSG00000233095(gene)|ensembl:ENSG00000235346(gene)|ensembl:ENSG00000235680(gene)|ensembl:ENSG00000237216(gene)|ensembl:ENST00000360323(transcript)|ensembl:ENST00000383621(transcript)|ensembl:ENST00000423011(transcript)|ensembl:ENST00000423373(transcript)|ensembl:ENST00000428701(transcript)|ensembl:ENST00000428952(transcript)|ensembl:ENST00000444098(transcript)|ensembl:ENST00000449127(transcript)|ensembl:ENST00000546545(transcript)|ensembl:ENST00000546634(transcript)|ensembl:ENST00000547241(transcript)|ensembl:ENST00000547931(transcript)|ensembl:ENST00000550897(transcript)|ensembl:ENST00000553052(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002451"(peripheral B cell tolerance induction)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0002476"(antigen processing and presentation of endogenous peptide antigen via MHC class Ib)|go:"GO:0002645"(positive regulation of tolerance induction)|go:"GO:0002666"(positive regulation of T cell tolerance induction)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0002767"(immune response-inhibiting cell surface receptor signaling pathway)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006968"(cellular defense response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0033106"(cis-Golgi network membrane)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0031527"(filopodium membrane)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0070207"(protein homotrimerization)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000774"(positive regulation of cellular senescence)|go:"GO:2001199"(negative regulation of dendritic cell differentiation)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|mint:P17693|rcsb pdb:1YDP|rcsb pdb:2D31|rcsb pdb:2DYP|rcsb pdb:3BZE|rcsb pdb:3CDG|rcsb pdb:3CII|rcsb pdb:3KYN|rcsb pdb:3KYO|rcsb pdb:6AEE|rcsb pdb:6K60|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|refseq:NP_002118.1|dip:DIP-46121N	-	-	-	figure legend:Supp fig 1, Supp. table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:2.1x10^-6(molar)	2017/06/01	2017/07/24	rogid:VQoEp3F8lEBTOj+PDDUzrJCQNZA9606	rogid:E3xsP+XcQvU64mCe/05DTS9vHQw9606	rigid:TSvimsejCtUmAt5KFPAFwVqDWwU	false	sufficient binding region:78-86	biotin tag:c-c|sufficient binding region:25-300	2	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P16104	uniprotkb:P61769-PRO_0000018779	intact:EBI-494830|uniprotkb:Q4ZGJ7|uniprotkb:Q6IAS5|ensembl:ENSP00000364310|ensembl:ENSP00000434024	intact:EBI-13942645	psi-mi:h2ax_human(display_long)|uniprotkb:H2AX(gene name)|psi-mi:H2AX(display_short)|uniprotkb:H2AFX(gene name synonym)|uniprotkb:Histone H2A.X(gene name synonym)	psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name)	psi-mi:"MI:0107"(surface plasmon resonance)	Shiroishi et al. (2006)	pubmed:16455647|imex:IM-26251	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-15485792|imex:IM-26251-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000188486(gene)|ensembl:ENST00000375167(transcript)|ensembl:ENST00000530167(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000786"(nucleosome)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0001741"(XY body)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|refseq:NP_002096.1|dip:DIP-33604N|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-3214858|reactome:R-HSA-427359|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5334118|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5625886|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-606279|reactome:R-HSA-69473|reactome:R-HSA-73728|reactome:R-HSA-73772|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9670095|reactome:R-HSA-9710421|reactome:R-HSA-977225|go:"GO:0005813"(centrosome)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006342"|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042393"(histone binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0090398"(cellular senescence)|go:"GO:0090734"(site of DNA damage)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P16104|rcsb pdb:1YDP|rcsb pdb:2AZM|rcsb pdb:2D31|rcsb pdb:2DYP|rcsb pdb:3SHV|rcsb pdb:3SQD|rcsb pdb:3SZM|rcsb pdb:3U3Z|rcsb pdb:6K1I|rcsb pdb:6K1J|rcsb pdb:6K1K	intact:EBI-714718(chain-parent)	-	-	chain-seq-start:21|chain-seq-end:119	figure legend:Supp fig 1, Supp. table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:2.1x10^-6(molar)	2017/06/01	2017/07/24	rogid:VQoEp3F8lEBTOj+PDDUzrJCQNZA9606	rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606	rigid:TSvimsejCtUmAt5KFPAFwVqDWwU	false	sufficient binding region:78-86	sufficient binding region:1-99	2	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P16104	uniprotkb:Q8NHL6	intact:EBI-494830|uniprotkb:Q4ZGJ7|uniprotkb:Q6IAS5|ensembl:ENSP00000364310|ensembl:ENSP00000434024	intact:EBI-2805262|uniprotkb:Q8NHK0|uniprotkb:Q8NHJ9|uniprotkb:O75025|uniprotkb:O75024|uniprotkb:A8MXT0|ensembl:ENSP00000480365|ensembl:ENSP00000481700|uniprotkb:A2IXV4	psi-mi:h2ax_human(display_long)|uniprotkb:H2AX(gene name)|psi-mi:H2AX(display_short)|uniprotkb:H2AFX(gene name synonym)|uniprotkb:Histone H2A.X(gene name synonym)	psi-mi:lirb1_human(display_long)|uniprotkb:ILT2(gene name synonym)|uniprotkb:LIR1(gene name synonym)|uniprotkb:MIR7(gene name synonym)|uniprotkb:CD85 antigen-like family member J(gene name synonym)|uniprotkb:Immunoglobulin-like transcript 2(gene name synonym)|uniprotkb:Monocyte/macrophage immunoglobulin-like receptor 7(gene name synonym)|uniprotkb:LILRB1(gene name)|psi-mi:LILRB1(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	Shiroishi et al. (2006)	pubmed:16455647|imex:IM-26251	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-15485811|imex:IM-26251-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000188486(gene)|ensembl:ENST00000375167(transcript)|ensembl:ENST00000530167(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000786"(nucleosome)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0001741"(XY body)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|refseq:NP_002096.1|dip:DIP-33604N|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-3214858|reactome:R-HSA-427359|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5334118|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5625886|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-606279|reactome:R-HSA-69473|reactome:R-HSA-73728|reactome:R-HSA-73772|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9670095|reactome:R-HSA-9710421|reactome:R-HSA-977225|go:"GO:0005813"(centrosome)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006342"|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042393"(histone binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0090398"(cellular senescence)|go:"GO:0090734"(site of DNA damage)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P16104|rcsb pdb:1YDP|rcsb pdb:2AZM|rcsb pdb:2D31|rcsb pdb:2DYP|rcsb pdb:3SHV|rcsb pdb:3SQD|rcsb pdb:3SZM|rcsb pdb:3U3Z|rcsb pdb:6K1I|rcsb pdb:6K1J|rcsb pdb:6K1K	ensembl:ENSG00000274669(gene)|ensembl:ENSG00000277807(gene)|ensembl:ENST00000616408(transcript)|ensembl:ENST00000618055(transcript)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002767"(immune response-inhibiting cell surface receptor signaling pathway)|go:"GO:0002774"(Fc receptor mediated inhibitory signaling pathway)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014063"(negative regulation of serotonin secretion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023025"(MHC class Ib protein complex binding)|go:"GO:0023029"(MHC class Ib protein binding)|go:"GO:0030107"(HLA-A specific inhibitory MHC class I receptor activity)|go:"GO:0030109"(HLA-B specific inhibitory MHC class I receptor activity)|go:"GO:0031623"(receptor internalization)|go:"GO:0032393"(MHC class I receptor activity)|go:"GO:0032394"(MHC class Ib receptor activity)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032945"(negative regulation of mononuclear cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046636"(negative regulation of alpha-beta T cell activation)|go:"GO:0051607"(defense response to virus)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071635"(negative regulation of transforming growth factor beta production)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|go:"GO:2001186"(negative regulation of CD8-positive, alpha-beta T cell activation)|go:"GO:2001189"(negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|go:"GO:2001193"(positive regulation of gamma-delta T cell activation involved in immune response)|go:"GO:2001199"(negative regulation of dendritic cell differentiation)|go:"GO:2001205"(negative regulation of osteoclast development)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:Q8NHL6|rcsb pdb:1G0X|rcsb pdb:1P7Q|rcsb pdb:1UFU|rcsb pdb:1UGN|rcsb pdb:1VDG|rcsb pdb:3D2U|rcsb pdb:4LL9|rcsb pdb:4NO0|rcsb pdb:5KNM|rcsb pdb:6AEE|rcsb pdb:6EWA|rcsb pdb:6EWC|rcsb pdb:6EWO|rcsb pdb:6K60|rcsb pdb:6ZDX|rcsb pdb:7KFK|reactome:R-HSA-198933|go:"GO:0097028"(dendritic cell differentiation)|refseq:NP_001265328.2|refseq:NP_001075106.2|refseq:NP_001075107.2|refseq:NP_001075108.2|refseq:NP_001265327.2|refseq:NP_006660.4	-	-	-	figure legend:Supp fig 1, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:2.5x10^-6(molar)	2017/06/01	2017/07/24	rogid:VQoEp3F8lEBTOj+PDDUzrJCQNZA9606	rogid:c3bdpF4SePNjbOkhewak+Vj98hU9606	rigid:TSvimsejCtUmAt5KFPAFwVqDWwU	false	sufficient binding region:78-86	sufficient binding region:24-220..220	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P16104	uniprotkb:P17693	intact:EBI-494830|uniprotkb:Q4ZGJ7|uniprotkb:Q6IAS5|ensembl:ENSP00000364310|ensembl:ENSP00000434024	intact:EBI-1043063|ensembl:ENSP00000353472|ensembl:ENSP00000388176|ensembl:ENSP00000389522|ensembl:ENSP00000398200|ensembl:ENSP00000373116|ensembl:ENSP00000405238|ensembl:ENSP00000408773|ensembl:ENSP00000412927|ensembl:ENSP00000447762|ensembl:ENSP00000447780|ensembl:ENSP00000448085|ensembl:ENSP00000448363|ensembl:ENSP00000449291|ensembl:ENSP00000449903	psi-mi:h2ax_human(display_long)|uniprotkb:H2AX(gene name)|psi-mi:H2AX(display_short)|uniprotkb:H2AFX(gene name synonym)|uniprotkb:Histone H2A.X(gene name synonym)	psi-mi:hlag_human(display_long)|uniprotkb:HLAG(gene name synonym)|uniprotkb:HLA-G(gene name)|psi-mi:HLA-G(display_short)|uniprotkb:HLA-6.0(gene name synonym)|uniprotkb:HLA G antigen(gene name synonym)|uniprotkb:MHC class I antigen G(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Shiroishi et al. (2006)	pubmed:16455647|imex:IM-26251	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-15485811|imex:IM-26251-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000188486(gene)|ensembl:ENST00000375167(transcript)|ensembl:ENST00000530167(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000786"(nucleosome)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0001741"(XY body)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|refseq:NP_002096.1|dip:DIP-33604N|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-3214858|reactome:R-HSA-427359|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5334118|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5625886|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-606279|reactome:R-HSA-69473|reactome:R-HSA-73728|reactome:R-HSA-73772|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9670095|reactome:R-HSA-9710421|reactome:R-HSA-977225|go:"GO:0005813"(centrosome)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006342"|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042393"(histone binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0090398"(cellular senescence)|go:"GO:0090734"(site of DNA damage)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P16104|rcsb pdb:1YDP|rcsb pdb:2AZM|rcsb pdb:2D31|rcsb pdb:2DYP|rcsb pdb:3SHV|rcsb pdb:3SQD|rcsb pdb:3SZM|rcsb pdb:3U3Z|rcsb pdb:6K1I|rcsb pdb:6K1J|rcsb pdb:6K1K	ensembl:ENSG00000204632(gene)|ensembl:ENSG00000206506(gene)|ensembl:ENSG00000230413(gene)|ensembl:ENSG00000233095(gene)|ensembl:ENSG00000235346(gene)|ensembl:ENSG00000235680(gene)|ensembl:ENSG00000237216(gene)|ensembl:ENST00000360323(transcript)|ensembl:ENST00000383621(transcript)|ensembl:ENST00000423011(transcript)|ensembl:ENST00000423373(transcript)|ensembl:ENST00000428701(transcript)|ensembl:ENST00000428952(transcript)|ensembl:ENST00000444098(transcript)|ensembl:ENST00000449127(transcript)|ensembl:ENST00000546545(transcript)|ensembl:ENST00000546634(transcript)|ensembl:ENST00000547241(transcript)|ensembl:ENST00000547931(transcript)|ensembl:ENST00000550897(transcript)|ensembl:ENST00000553052(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002451"(peripheral B cell tolerance induction)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0002476"(antigen processing and presentation of endogenous peptide antigen via MHC class Ib)|go:"GO:0002645"(positive regulation of tolerance induction)|go:"GO:0002666"(positive regulation of T cell tolerance induction)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0002767"(immune response-inhibiting cell surface receptor signaling pathway)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006968"(cellular defense response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0033106"(cis-Golgi network membrane)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0031527"(filopodium membrane)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0070207"(protein homotrimerization)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000774"(positive regulation of cellular senescence)|go:"GO:2001199"(negative regulation of dendritic cell differentiation)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|mint:P17693|rcsb pdb:1YDP|rcsb pdb:2D31|rcsb pdb:2DYP|rcsb pdb:3BZE|rcsb pdb:3CDG|rcsb pdb:3CII|rcsb pdb:3KYN|rcsb pdb:3KYO|rcsb pdb:6AEE|rcsb pdb:6K60|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|refseq:NP_002118.1|dip:DIP-46121N	-	-	-	figure legend:Supp fig 1, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:2.5x10^-6(molar)	2017/06/01	2017/07/24	rogid:VQoEp3F8lEBTOj+PDDUzrJCQNZA9606	rogid:E3xsP+XcQvU64mCe/05DTS9vHQw9606	rigid:TSvimsejCtUmAt5KFPAFwVqDWwU	false	sufficient binding region:78-86	sufficient binding region:25-300|biotin tag:c-c	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P16104	uniprotkb:P61769-PRO_0000018779	intact:EBI-494830|uniprotkb:Q4ZGJ7|uniprotkb:Q6IAS5|ensembl:ENSP00000364310|ensembl:ENSP00000434024	intact:EBI-13942645	psi-mi:h2ax_human(display_long)|uniprotkb:H2AX(gene name)|psi-mi:H2AX(display_short)|uniprotkb:H2AFX(gene name synonym)|uniprotkb:Histone H2A.X(gene name synonym)	psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name)	psi-mi:"MI:0107"(surface plasmon resonance)	Shiroishi et al. (2006)	pubmed:16455647|imex:IM-26251	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-15485811|imex:IM-26251-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000188486(gene)|ensembl:ENST00000375167(transcript)|ensembl:ENST00000530167(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000786"(nucleosome)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0001741"(XY body)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|refseq:NP_002096.1|dip:DIP-33604N|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-3214858|reactome:R-HSA-427359|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5334118|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5625886|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-606279|reactome:R-HSA-69473|reactome:R-HSA-73728|reactome:R-HSA-73772|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9670095|reactome:R-HSA-9710421|reactome:R-HSA-977225|go:"GO:0005813"(centrosome)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006342"|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042393"(histone binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0090398"(cellular senescence)|go:"GO:0090734"(site of DNA damage)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P16104|rcsb pdb:1YDP|rcsb pdb:2AZM|rcsb pdb:2D31|rcsb pdb:2DYP|rcsb pdb:3SHV|rcsb pdb:3SQD|rcsb pdb:3SZM|rcsb pdb:3U3Z|rcsb pdb:6K1I|rcsb pdb:6K1J|rcsb pdb:6K1K	intact:EBI-714718(chain-parent)	-	-	chain-seq-start:21|chain-seq-end:119	figure legend:Supp fig 1, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:2.5x10^-6(molar)	2017/06/01	2017/07/24	rogid:VQoEp3F8lEBTOj+PDDUzrJCQNZA9606	rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606	rigid:TSvimsejCtUmAt5KFPAFwVqDWwU	false	sufficient binding region:78-86	sufficient binding region:1-99	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P16104	uniprotkb:Q8N423	intact:EBI-494830|uniprotkb:Q4ZGJ7|uniprotkb:Q6IAS5|ensembl:ENSP00000364310|ensembl:ENSP00000434024	intact:EBI-2816428|uniprotkb:Q8NHJ7|uniprotkb:Q8NHJ8|uniprotkb:O75017|uniprotkb:A8MU67|uniprotkb:C9JF29|ensembl:ENSP00000319960|ensembl:ENSP00000375626|ensembl:ENSP00000375628|ensembl:ENSP00000375629|ensembl:ENSP00000410117|ensembl:ENSP00000480302|ensembl:ENSP00000481208|ensembl:ENSP00000482933|ensembl:ENSP00000483553|ensembl:ENSP00000484373	psi-mi:h2ax_human(display_long)|uniprotkb:H2AX(gene name)|psi-mi:H2AX(display_short)|uniprotkb:H2AFX(gene name synonym)|uniprotkb:Histone H2A.X(gene name synonym)	psi-mi:lirb2_human(display_long)|uniprotkb:LILRB2(gene name)|psi-mi:LILRB2(display_short)|uniprotkb:ILT4(gene name synonym)|uniprotkb:LIR2(gene name synonym)|uniprotkb:MIR10(gene name synonym)|uniprotkb:CD85 antigen-like family member D(gene name synonym)|uniprotkb:Immunoglobulin-like transcript 4(gene name synonym)|uniprotkb:Monocyte/macrophage immunoglobulin-like receptor 10(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Shiroishi et al. (2006)	pubmed:16455647|imex:IM-26251	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-15485835|imex:IM-26251-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000188486(gene)|ensembl:ENST00000375167(transcript)|ensembl:ENST00000530167(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000786"(nucleosome)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0001741"(XY body)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|refseq:NP_002096.1|dip:DIP-33604N|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-3214858|reactome:R-HSA-427359|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5334118|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5625886|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-606279|reactome:R-HSA-69473|reactome:R-HSA-73728|reactome:R-HSA-73772|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9670095|reactome:R-HSA-9710421|reactome:R-HSA-977225|go:"GO:0005813"(centrosome)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006342"|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042393"(histone binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0090398"(cellular senescence)|go:"GO:0090734"(site of DNA damage)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P16104|rcsb pdb:1YDP|rcsb pdb:2AZM|rcsb pdb:2D31|rcsb pdb:2DYP|rcsb pdb:3SHV|rcsb pdb:3SQD|rcsb pdb:3SZM|rcsb pdb:3U3Z|rcsb pdb:6K1I|rcsb pdb:6K1J|rcsb pdb:6K1K	dip:DIP-59888N|ensembl:ENSG00000131042(gene)|ensembl:ENSG00000274513(gene)|ensembl:ENSG00000275463(gene)|ensembl:ENSG00000276146(gene)|ensembl:ENST00000314446(transcript)|ensembl:ENST00000391746(transcript)|ensembl:ENST00000391748(transcript)|ensembl:ENST00000391749(transcript)|ensembl:ENST00000434421(transcript)|ensembl:ENST00000610886(transcript)|ensembl:ENST00000617341(transcript)|ensembl:ENST00000617886(transcript)|ensembl:ENST00000618392(transcript)|ensembl:ENST00000618705(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002578"(negative regulation of antigen processing and presentation)|go:"GO:0002645"(positive regulation of tolerance induction)|go:"GO:0002666"(positive regulation of T cell tolerance induction)|go:"GO:0002767"(immune response-inhibiting cell surface receptor signaling pathway)|go:"GO:0002774"(Fc receptor mediated inhibitory signaling pathway)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007611"(learning or memory)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0023025"(MHC class Ib protein complex binding)|go:"GO:0023029"(MHC class Ib protein binding)|go:"GO:0032396"(inhibitory MHC class I receptor activity)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:0140105"(interleukin-10-mediated signaling pathway)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1905875"(negative regulation of postsynaptic density organization)|go:"GO:2000524"(negative regulation of T cell costimulation)|go:"GO:2001198"(regulation of dendritic cell differentiation)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2DYP|rcsb pdb:2GW5|rcsb pdb:4LLA|rcsb pdb:6AED|rcsb pdb:6BCS|reactome:R-HSA-198933|reactome:R-HSA-6798695	-	-	-	figure legend:Supp fig 1, Supp. table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:4.0x10^-6(molar)	2017/06/01	2017/07/24	rogid:VQoEp3F8lEBTOj+PDDUzrJCQNZA9606	rogid:nFaZ5NEqw5u/3Du7Mi6fJpEQEdo9606	rigid:2gds+HZnweS0A+xafr7u8+xG2NY	false	sufficient binding region:78-86	sufficient binding region:24-221..221	2	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P16104	uniprotkb:P17693	intact:EBI-494830|uniprotkb:Q4ZGJ7|uniprotkb:Q6IAS5|ensembl:ENSP00000364310|ensembl:ENSP00000434024	intact:EBI-1043063|ensembl:ENSP00000353472|ensembl:ENSP00000388176|ensembl:ENSP00000389522|ensembl:ENSP00000398200|ensembl:ENSP00000373116|ensembl:ENSP00000405238|ensembl:ENSP00000408773|ensembl:ENSP00000412927|ensembl:ENSP00000447762|ensembl:ENSP00000447780|ensembl:ENSP00000448085|ensembl:ENSP00000448363|ensembl:ENSP00000449291|ensembl:ENSP00000449903	psi-mi:h2ax_human(display_long)|uniprotkb:H2AX(gene name)|psi-mi:H2AX(display_short)|uniprotkb:H2AFX(gene name synonym)|uniprotkb:Histone H2A.X(gene name synonym)	psi-mi:hlag_human(display_long)|uniprotkb:HLAG(gene name synonym)|uniprotkb:HLA-G(gene name)|psi-mi:HLA-G(display_short)|uniprotkb:HLA-6.0(gene name synonym)|uniprotkb:HLA G antigen(gene name synonym)|uniprotkb:MHC class I antigen G(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Shiroishi et al. (2006)	pubmed:16455647|imex:IM-26251	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-15485835|imex:IM-26251-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000188486(gene)|ensembl:ENST00000375167(transcript)|ensembl:ENST00000530167(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000786"(nucleosome)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0001741"(XY body)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|refseq:NP_002096.1|dip:DIP-33604N|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-3214858|reactome:R-HSA-427359|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5334118|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5625886|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-606279|reactome:R-HSA-69473|reactome:R-HSA-73728|reactome:R-HSA-73772|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9670095|reactome:R-HSA-9710421|reactome:R-HSA-977225|go:"GO:0005813"(centrosome)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006342"|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042393"(histone binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0090398"(cellular senescence)|go:"GO:0090734"(site of DNA damage)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P16104|rcsb pdb:1YDP|rcsb pdb:2AZM|rcsb pdb:2D31|rcsb pdb:2DYP|rcsb pdb:3SHV|rcsb pdb:3SQD|rcsb pdb:3SZM|rcsb pdb:3U3Z|rcsb pdb:6K1I|rcsb pdb:6K1J|rcsb pdb:6K1K	ensembl:ENSG00000204632(gene)|ensembl:ENSG00000206506(gene)|ensembl:ENSG00000230413(gene)|ensembl:ENSG00000233095(gene)|ensembl:ENSG00000235346(gene)|ensembl:ENSG00000235680(gene)|ensembl:ENSG00000237216(gene)|ensembl:ENST00000360323(transcript)|ensembl:ENST00000383621(transcript)|ensembl:ENST00000423011(transcript)|ensembl:ENST00000423373(transcript)|ensembl:ENST00000428701(transcript)|ensembl:ENST00000428952(transcript)|ensembl:ENST00000444098(transcript)|ensembl:ENST00000449127(transcript)|ensembl:ENST00000546545(transcript)|ensembl:ENST00000546634(transcript)|ensembl:ENST00000547241(transcript)|ensembl:ENST00000547931(transcript)|ensembl:ENST00000550897(transcript)|ensembl:ENST00000553052(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002451"(peripheral B cell tolerance induction)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0002476"(antigen processing and presentation of endogenous peptide antigen via MHC class Ib)|go:"GO:0002645"(positive regulation of tolerance induction)|go:"GO:0002666"(positive regulation of T cell tolerance induction)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0002767"(immune response-inhibiting cell surface receptor signaling pathway)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006968"(cellular defense response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0033106"(cis-Golgi network membrane)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0031527"(filopodium membrane)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0070207"(protein homotrimerization)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000774"(positive regulation of cellular senescence)|go:"GO:2001199"(negative regulation of dendritic cell differentiation)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|mint:P17693|rcsb pdb:1YDP|rcsb pdb:2D31|rcsb pdb:2DYP|rcsb pdb:3BZE|rcsb pdb:3CDG|rcsb pdb:3CII|rcsb pdb:3KYN|rcsb pdb:3KYO|rcsb pdb:6AEE|rcsb pdb:6K60|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|refseq:NP_002118.1|dip:DIP-46121N	-	-	-	figure legend:Supp fig 1, Supp. table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:4.0x10^-6(molar)	2017/06/01	2017/07/24	rogid:VQoEp3F8lEBTOj+PDDUzrJCQNZA9606	rogid:E3xsP+XcQvU64mCe/05DTS9vHQw9606	rigid:2gds+HZnweS0A+xafr7u8+xG2NY	false	sufficient binding region:78-86	biotin tag:c-c|sufficient binding region:25-300	2	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P16104	uniprotkb:P61769-PRO_0000018779	intact:EBI-494830|uniprotkb:Q4ZGJ7|uniprotkb:Q6IAS5|ensembl:ENSP00000364310|ensembl:ENSP00000434024	intact:EBI-13942645	psi-mi:h2ax_human(display_long)|uniprotkb:H2AX(gene name)|psi-mi:H2AX(display_short)|uniprotkb:H2AFX(gene name synonym)|uniprotkb:Histone H2A.X(gene name synonym)	psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name)	psi-mi:"MI:0107"(surface plasmon resonance)	Shiroishi et al. (2006)	pubmed:16455647|imex:IM-26251	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-15485835|imex:IM-26251-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000188486(gene)|ensembl:ENST00000375167(transcript)|ensembl:ENST00000530167(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000786"(nucleosome)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0001741"(XY body)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|refseq:NP_002096.1|dip:DIP-33604N|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-3214858|reactome:R-HSA-427359|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5334118|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5625886|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-606279|reactome:R-HSA-69473|reactome:R-HSA-73728|reactome:R-HSA-73772|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9670095|reactome:R-HSA-9710421|reactome:R-HSA-977225|go:"GO:0005813"(centrosome)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006342"|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042393"(histone binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0090398"(cellular senescence)|go:"GO:0090734"(site of DNA damage)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P16104|rcsb pdb:1YDP|rcsb pdb:2AZM|rcsb pdb:2D31|rcsb pdb:2DYP|rcsb pdb:3SHV|rcsb pdb:3SQD|rcsb pdb:3SZM|rcsb pdb:3U3Z|rcsb pdb:6K1I|rcsb pdb:6K1J|rcsb pdb:6K1K	intact:EBI-714718(chain-parent)	-	-	chain-seq-start:21|chain-seq-end:119	figure legend:Supp fig 1, Supp. table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:4.0x10^-6(molar)	2017/06/01	2017/07/24	rogid:VQoEp3F8lEBTOj+PDDUzrJCQNZA9606	rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606	rigid:2gds+HZnweS0A+xafr7u8+xG2NY	false	sufficient binding region:78-86	sufficient binding region:1-99	2	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P16104	uniprotkb:Q8N423	intact:EBI-494830|uniprotkb:Q4ZGJ7|uniprotkb:Q6IAS5|ensembl:ENSP00000364310|ensembl:ENSP00000434024	intact:EBI-2816428|uniprotkb:Q8NHJ7|uniprotkb:Q8NHJ8|uniprotkb:O75017|uniprotkb:A8MU67|uniprotkb:C9JF29|ensembl:ENSP00000319960|ensembl:ENSP00000375626|ensembl:ENSP00000375628|ensembl:ENSP00000375629|ensembl:ENSP00000410117|ensembl:ENSP00000480302|ensembl:ENSP00000481208|ensembl:ENSP00000482933|ensembl:ENSP00000483553|ensembl:ENSP00000484373	psi-mi:h2ax_human(display_long)|uniprotkb:H2AX(gene name)|psi-mi:H2AX(display_short)|uniprotkb:H2AFX(gene name synonym)|uniprotkb:Histone H2A.X(gene name synonym)	psi-mi:lirb2_human(display_long)|uniprotkb:LILRB2(gene name)|psi-mi:LILRB2(display_short)|uniprotkb:ILT4(gene name synonym)|uniprotkb:LIR2(gene name synonym)|uniprotkb:MIR10(gene name synonym)|uniprotkb:CD85 antigen-like family member D(gene name synonym)|uniprotkb:Immunoglobulin-like transcript 4(gene name synonym)|uniprotkb:Monocyte/macrophage immunoglobulin-like receptor 10(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Shiroishi et al. (2006)	pubmed:16455647|imex:IM-26251	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-15485855|imex:IM-26251-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000188486(gene)|ensembl:ENST00000375167(transcript)|ensembl:ENST00000530167(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000786"(nucleosome)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0001741"(XY body)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|refseq:NP_002096.1|dip:DIP-33604N|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-3214858|reactome:R-HSA-427359|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5334118|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5625886|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-606279|reactome:R-HSA-69473|reactome:R-HSA-73728|reactome:R-HSA-73772|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9670095|reactome:R-HSA-9710421|reactome:R-HSA-977225|go:"GO:0005813"(centrosome)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006342"|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042393"(histone binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0090398"(cellular senescence)|go:"GO:0090734"(site of DNA damage)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P16104|rcsb pdb:1YDP|rcsb pdb:2AZM|rcsb pdb:2D31|rcsb pdb:2DYP|rcsb pdb:3SHV|rcsb pdb:3SQD|rcsb pdb:3SZM|rcsb pdb:3U3Z|rcsb pdb:6K1I|rcsb pdb:6K1J|rcsb pdb:6K1K	dip:DIP-59888N|ensembl:ENSG00000131042(gene)|ensembl:ENSG00000274513(gene)|ensembl:ENSG00000275463(gene)|ensembl:ENSG00000276146(gene)|ensembl:ENST00000314446(transcript)|ensembl:ENST00000391746(transcript)|ensembl:ENST00000391748(transcript)|ensembl:ENST00000391749(transcript)|ensembl:ENST00000434421(transcript)|ensembl:ENST00000610886(transcript)|ensembl:ENST00000617341(transcript)|ensembl:ENST00000617886(transcript)|ensembl:ENST00000618392(transcript)|ensembl:ENST00000618705(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002578"(negative regulation of antigen processing and presentation)|go:"GO:0002645"(positive regulation of tolerance induction)|go:"GO:0002666"(positive regulation of T cell tolerance induction)|go:"GO:0002767"(immune response-inhibiting cell surface receptor signaling pathway)|go:"GO:0002774"(Fc receptor mediated inhibitory signaling pathway)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007611"(learning or memory)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0023025"(MHC class Ib protein complex binding)|go:"GO:0023029"(MHC class Ib protein binding)|go:"GO:0032396"(inhibitory MHC class I receptor activity)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:0140105"(interleukin-10-mediated signaling pathway)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1905875"(negative regulation of postsynaptic density organization)|go:"GO:2000524"(negative regulation of T cell costimulation)|go:"GO:2001198"(regulation of dendritic cell differentiation)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2DYP|rcsb pdb:2GW5|rcsb pdb:4LLA|rcsb pdb:6AED|rcsb pdb:6BCS|reactome:R-HSA-198933|reactome:R-HSA-6798695	-	-	-	figure legend:Supp fig 1, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:4.3x10^-6(molar)	2017/06/01	2017/07/24	rogid:VQoEp3F8lEBTOj+PDDUzrJCQNZA9606	rogid:nFaZ5NEqw5u/3Du7Mi6fJpEQEdo9606	rigid:2gds+HZnweS0A+xafr7u8+xG2NY	false	sufficient binding region:78-86	sufficient binding region:24-221..221	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P16104	uniprotkb:P17693	intact:EBI-494830|uniprotkb:Q4ZGJ7|uniprotkb:Q6IAS5|ensembl:ENSP00000364310|ensembl:ENSP00000434024	intact:EBI-1043063|ensembl:ENSP00000353472|ensembl:ENSP00000388176|ensembl:ENSP00000389522|ensembl:ENSP00000398200|ensembl:ENSP00000373116|ensembl:ENSP00000405238|ensembl:ENSP00000408773|ensembl:ENSP00000412927|ensembl:ENSP00000447762|ensembl:ENSP00000447780|ensembl:ENSP00000448085|ensembl:ENSP00000448363|ensembl:ENSP00000449291|ensembl:ENSP00000449903	psi-mi:h2ax_human(display_long)|uniprotkb:H2AX(gene name)|psi-mi:H2AX(display_short)|uniprotkb:H2AFX(gene name synonym)|uniprotkb:Histone H2A.X(gene name synonym)	psi-mi:hlag_human(display_long)|uniprotkb:HLAG(gene name synonym)|uniprotkb:HLA-G(gene name)|psi-mi:HLA-G(display_short)|uniprotkb:HLA-6.0(gene name synonym)|uniprotkb:HLA G antigen(gene name synonym)|uniprotkb:MHC class I antigen G(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Shiroishi et al. (2006)	pubmed:16455647|imex:IM-26251	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-15485855|imex:IM-26251-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000188486(gene)|ensembl:ENST00000375167(transcript)|ensembl:ENST00000530167(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000786"(nucleosome)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0001741"(XY body)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|refseq:NP_002096.1|dip:DIP-33604N|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-3214858|reactome:R-HSA-427359|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5334118|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5625886|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-606279|reactome:R-HSA-69473|reactome:R-HSA-73728|reactome:R-HSA-73772|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9670095|reactome:R-HSA-9710421|reactome:R-HSA-977225|go:"GO:0005813"(centrosome)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006342"|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042393"(histone binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0090398"(cellular senescence)|go:"GO:0090734"(site of DNA damage)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P16104|rcsb pdb:1YDP|rcsb pdb:2AZM|rcsb pdb:2D31|rcsb pdb:2DYP|rcsb pdb:3SHV|rcsb pdb:3SQD|rcsb pdb:3SZM|rcsb pdb:3U3Z|rcsb pdb:6K1I|rcsb pdb:6K1J|rcsb pdb:6K1K	ensembl:ENSG00000204632(gene)|ensembl:ENSG00000206506(gene)|ensembl:ENSG00000230413(gene)|ensembl:ENSG00000233095(gene)|ensembl:ENSG00000235346(gene)|ensembl:ENSG00000235680(gene)|ensembl:ENSG00000237216(gene)|ensembl:ENST00000360323(transcript)|ensembl:ENST00000383621(transcript)|ensembl:ENST00000423011(transcript)|ensembl:ENST00000423373(transcript)|ensembl:ENST00000428701(transcript)|ensembl:ENST00000428952(transcript)|ensembl:ENST00000444098(transcript)|ensembl:ENST00000449127(transcript)|ensembl:ENST00000546545(transcript)|ensembl:ENST00000546634(transcript)|ensembl:ENST00000547241(transcript)|ensembl:ENST00000547931(transcript)|ensembl:ENST00000550897(transcript)|ensembl:ENST00000553052(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002451"(peripheral B cell tolerance induction)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0002476"(antigen processing and presentation of endogenous peptide antigen via MHC class Ib)|go:"GO:0002645"(positive regulation of tolerance induction)|go:"GO:0002666"(positive regulation of T cell tolerance induction)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0002767"(immune response-inhibiting cell surface receptor signaling pathway)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006968"(cellular defense response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0033106"(cis-Golgi network membrane)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0031527"(filopodium membrane)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0070207"(protein homotrimerization)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000774"(positive regulation of cellular senescence)|go:"GO:2001199"(negative regulation of dendritic cell differentiation)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|mint:P17693|rcsb pdb:1YDP|rcsb pdb:2D31|rcsb pdb:2DYP|rcsb pdb:3BZE|rcsb pdb:3CDG|rcsb pdb:3CII|rcsb pdb:3KYN|rcsb pdb:3KYO|rcsb pdb:6AEE|rcsb pdb:6K60|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|refseq:NP_002118.1|dip:DIP-46121N	-	-	-	figure legend:Supp fig 1, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:4.3x10^-6(molar)	2017/06/01	2017/07/24	rogid:VQoEp3F8lEBTOj+PDDUzrJCQNZA9606	rogid:E3xsP+XcQvU64mCe/05DTS9vHQw9606	rigid:2gds+HZnweS0A+xafr7u8+xG2NY	false	sufficient binding region:78-86	sufficient binding region:25-300|biotin tag:c-c|mutation with no effect:66-66	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P16104	uniprotkb:P61769-PRO_0000018779	intact:EBI-494830|uniprotkb:Q4ZGJ7|uniprotkb:Q6IAS5|ensembl:ENSP00000364310|ensembl:ENSP00000434024	intact:EBI-13942645	psi-mi:h2ax_human(display_long)|uniprotkb:H2AX(gene name)|psi-mi:H2AX(display_short)|uniprotkb:H2AFX(gene name synonym)|uniprotkb:Histone H2A.X(gene name synonym)	psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name)	psi-mi:"MI:0107"(surface plasmon resonance)	Shiroishi et al. (2006)	pubmed:16455647|imex:IM-26251	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-15485855|imex:IM-26251-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000188486(gene)|ensembl:ENST00000375167(transcript)|ensembl:ENST00000530167(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000786"(nucleosome)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0001741"(XY body)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|refseq:NP_002096.1|dip:DIP-33604N|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-3214858|reactome:R-HSA-427359|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5334118|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5625886|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-606279|reactome:R-HSA-69473|reactome:R-HSA-73728|reactome:R-HSA-73772|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9670095|reactome:R-HSA-9710421|reactome:R-HSA-977225|go:"GO:0005813"(centrosome)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006342"|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042393"(histone binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0090398"(cellular senescence)|go:"GO:0090734"(site of DNA damage)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P16104|rcsb pdb:1YDP|rcsb pdb:2AZM|rcsb pdb:2D31|rcsb pdb:2DYP|rcsb pdb:3SHV|rcsb pdb:3SQD|rcsb pdb:3SZM|rcsb pdb:3U3Z|rcsb pdb:6K1I|rcsb pdb:6K1J|rcsb pdb:6K1K	intact:EBI-714718(chain-parent)	-	-	chain-seq-start:21|chain-seq-end:119	figure legend:Supp fig 1, Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:4.3x10^-6(molar)	2017/06/01	2017/07/24	rogid:VQoEp3F8lEBTOj+PDDUzrJCQNZA9606	rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606	rigid:2gds+HZnweS0A+xafr7u8+xG2NY	false	sufficient binding region:78-86	sufficient binding region:1-99	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)