#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O43353	uniprotkb:Q9BX69	intact:EBI-358522|uniprotkb:Q6UWF0|uniprotkb:B7Z748|ensembl:ENSP00000220751	intact:EBI-14405242|ensembl:ENSP00000254691|uniprotkb:Q52LR2	psi-mi:ripk2_human(display_long)|uniprotkb:RIPK2(gene name)|psi-mi:RIPK2(display_short)|uniprotkb:CARDIAK(gene name synonym)|uniprotkb:RICK(gene name synonym)|uniprotkb:RIP2(gene name synonym)|uniprotkb:UNQ277/PRO314/PRO34092(orf name)|uniprotkb:RIP-like-interacting CLARP kinase(gene name synonym)|uniprotkb:Receptor-interacting protein 2(gene name synonym)|uniprotkb:CARD-containing interleukin-1 beta-converting enzyme-associated kinase(gene name synonym)|uniprotkb:Tyrosine-protein kinase RIPK2(gene name synonym)	psi-mi:card6_human(display_long)|uniprotkb:CARD6(gene name)|psi-mi:CARD6(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Dufner et al. (2006)	pubmed:16418290|doi:10.1073/pnas.0510380103|imex:IM-23395	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15565042|imex:IM-23395-1|dip:DIP-197431E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003812.1|go:"GO:0007165"(signal transduction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0006954"(inflammatory response)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033091"(positive regulation of immature T cell proliferation)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0045087"(innate immune response)|go:"GO:0045627"(positive regulation of T-helper 1 cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070427"(nucleotide-binding oligomerization domain containing 1 signaling pathway)|go:"GO:0070431"(nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070671"(response to interleukin-12)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0030274"(LIM domain binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031982"(vesicle)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|ensembl:ENSG00000104312(gene)|ensembl:ENST00000220751(transcript)|go:"GO:0001961"(positive regulation of cytokine-mediated signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002827"(positive regulation of T-helper 1 type immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006915"(apoptotic process)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071224"(cellular response to peptidoglycan)|go:"GO:0071225"(cellular response to muramyl dipeptide)|go:"GO:0089720"(caspase binding)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904417"(positive regulation of xenophagy)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR017322(Receptor-interacting serine/threonine-protein kinase 2)|interpro:IPR042149|mint:O43353|rcsb pdb:2N7Z|rcsb pdb:2N83|rcsb pdb:4C8B|rcsb pdb:5AR2|rcsb pdb:5AR3|rcsb pdb:5AR4|rcsb pdb:5AR5|rcsb pdb:5AR7|go:"GO:0070673"(response to interleukin-18)|rcsb pdb:5AR8|rcsb pdb:5J79|rcsb pdb:5J7B|rcsb pdb:5NG0|rcsb pdb:5NG2|rcsb pdb:5NG3|rcsb pdb:5W5J|rcsb pdb:5W5O|rcsb pdb:5YRN|rcsb pdb:6ES0|rcsb pdb:6FU5|rcsb pdb:6GFJ|rcsb pdb:6GGS|rcsb pdb:6HMX|rcsb pdb:6RN8|rcsb pdb:6RNA|rcsb pdb:6S1F|rcsb pdb:6SZE|rcsb pdb:6SZJ|rcsb pdb:6UL8|reactome:R-HSA-168638|reactome:R-HSA-202424|reactome:R-HSA-209543|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5689896|reactome:R-HSA-9020702|refseq:XP_005251149.1|dip:DIP-27518N	ensembl:ENSG00000132357(gene)|ensembl:ENST00000254691(transcript)|go:"GO:0006915"(apoptotic process)|go:"GO:0042981"(regulation of apoptotic process)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR011029(DEATH-like)|refseq:NP_115976.2|dip:DIP-61097N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/04	2017/08/10	rogid:vmVxb58HgNLVE3AgNkPsG0i7OXo9606	rogid:yV0IAFGVkhqPs4V4wah7p3gJd589606	rigid:aQq8COrs9evksdkO2y4hi4iOGRM	false	ha tag:c-c	mutation increasing interaction strength:33-33,31-31,30-30|flag tag:c-c|sufficient binding region:282-949	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9BX69	uniprotkb:O43353	intact:EBI-14405242|ensembl:ENSP00000254691|uniprotkb:Q52LR2	intact:EBI-358522|uniprotkb:Q6UWF0|uniprotkb:B7Z748|ensembl:ENSP00000220751	psi-mi:card6_human(display_long)|uniprotkb:CARD6(gene name)|psi-mi:CARD6(display_short)	psi-mi:ripk2_human(display_long)|uniprotkb:RIPK2(gene name)|psi-mi:RIPK2(display_short)|uniprotkb:CARDIAK(gene name synonym)|uniprotkb:RICK(gene name synonym)|uniprotkb:RIP2(gene name synonym)|uniprotkb:UNQ277/PRO314/PRO34092(orf name)|uniprotkb:RIP-like-interacting CLARP kinase(gene name synonym)|uniprotkb:Receptor-interacting protein 2(gene name synonym)|uniprotkb:CARD-containing interleukin-1 beta-converting enzyme-associated kinase(gene name synonym)|uniprotkb:Tyrosine-protein kinase RIPK2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Dufner et al. (2006)	pubmed:16418290|doi:10.1073/pnas.0510380103|imex:IM-23395	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15565070|imex:IM-23395-2|dip:DIP-197431E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000132357(gene)|ensembl:ENST00000254691(transcript)|go:"GO:0006915"(apoptotic process)|go:"GO:0042981"(regulation of apoptotic process)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR011029(DEATH-like)|refseq:NP_115976.2|dip:DIP-61097N	refseq:NP_003812.1|go:"GO:0007165"(signal transduction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0006954"(inflammatory response)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033091"(positive regulation of immature T cell proliferation)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0045087"(innate immune response)|go:"GO:0045627"(positive regulation of T-helper 1 cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070427"(nucleotide-binding oligomerization domain containing 1 signaling pathway)|go:"GO:0070431"(nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070671"(response to interleukin-12)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0030274"(LIM domain binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031982"(vesicle)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|ensembl:ENSG00000104312(gene)|ensembl:ENST00000220751(transcript)|go:"GO:0001961"(positive regulation of cytokine-mediated signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002827"(positive regulation of T-helper 1 type immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006915"(apoptotic process)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071224"(cellular response to peptidoglycan)|go:"GO:0071225"(cellular response to muramyl dipeptide)|go:"GO:0089720"(caspase binding)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904417"(positive regulation of xenophagy)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR017322(Receptor-interacting serine/threonine-protein kinase 2)|interpro:IPR042149|mint:O43353|rcsb pdb:2N7Z|rcsb pdb:2N83|rcsb pdb:4C8B|rcsb pdb:5AR2|rcsb pdb:5AR3|rcsb pdb:5AR4|rcsb pdb:5AR5|rcsb pdb:5AR7|go:"GO:0070673"(response to interleukin-18)|rcsb pdb:5AR8|rcsb pdb:5J79|rcsb pdb:5J7B|rcsb pdb:5NG0|rcsb pdb:5NG2|rcsb pdb:5NG3|rcsb pdb:5W5J|rcsb pdb:5W5O|rcsb pdb:5YRN|rcsb pdb:6ES0|rcsb pdb:6FU5|rcsb pdb:6GFJ|rcsb pdb:6GGS|rcsb pdb:6HMX|rcsb pdb:6RN8|rcsb pdb:6RNA|rcsb pdb:6S1F|rcsb pdb:6SZE|rcsb pdb:6SZJ|rcsb pdb:6UL8|reactome:R-HSA-168638|reactome:R-HSA-202424|reactome:R-HSA-209543|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5689896|reactome:R-HSA-9020702|refseq:XP_005251149.1|dip:DIP-27518N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/04	2017/08/10	rogid:yV0IAFGVkhqPs4V4wah7p3gJd589606	rogid:vmVxb58HgNLVE3AgNkPsG0i7OXo9606	rigid:aQq8COrs9evksdkO2y4hi4iOGRM	false	sufficient binding region:95-1037|flag tag:c-c	ha tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O43353	uniprotkb:E9PWH2	intact:EBI-358522|uniprotkb:Q6UWF0|uniprotkb:B7Z748|ensembl:ENSP00000220751	intact:EBI-15565093|ensembl:ENSMUSP00000112833	psi-mi:ripk2_human(display_long)|uniprotkb:RIPK2(gene name)|psi-mi:RIPK2(display_short)|uniprotkb:CARDIAK(gene name synonym)|uniprotkb:RICK(gene name synonym)|uniprotkb:RIP2(gene name synonym)|uniprotkb:UNQ277/PRO314/PRO34092(orf name)|uniprotkb:RIP-like-interacting CLARP kinase(gene name synonym)|uniprotkb:Receptor-interacting protein 2(gene name synonym)|uniprotkb:CARD-containing interleukin-1 beta-converting enzyme-associated kinase(gene name synonym)|uniprotkb:Tyrosine-protein kinase RIPK2(gene name synonym)	psi-mi:e9pwh2_mouse(display_long)|uniprotkb:Card6(gene name)|psi-mi:Card6(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Dufner et al. (2006)	pubmed:16418290|doi:10.1073/pnas.0510380103|imex:IM-23395	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15565112|imex:IM-23395-3|dip:DIP-197433E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003812.1|go:"GO:0007165"(signal transduction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0006954"(inflammatory response)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033091"(positive regulation of immature T cell proliferation)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0045087"(innate immune response)|go:"GO:0045627"(positive regulation of T-helper 1 cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070427"(nucleotide-binding oligomerization domain containing 1 signaling pathway)|go:"GO:0070431"(nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070671"(response to interleukin-12)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0030274"(LIM domain binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031982"(vesicle)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|ensembl:ENSG00000104312(gene)|ensembl:ENST00000220751(transcript)|go:"GO:0001961"(positive regulation of cytokine-mediated signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002827"(positive regulation of T-helper 1 type immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006915"(apoptotic process)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071224"(cellular response to peptidoglycan)|go:"GO:0071225"(cellular response to muramyl dipeptide)|go:"GO:0089720"(caspase binding)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904417"(positive regulation of xenophagy)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR017322(Receptor-interacting serine/threonine-protein kinase 2)|interpro:IPR042149|mint:O43353|rcsb pdb:2N7Z|rcsb pdb:2N83|rcsb pdb:4C8B|rcsb pdb:5AR2|rcsb pdb:5AR3|rcsb pdb:5AR4|rcsb pdb:5AR5|rcsb pdb:5AR7|go:"GO:0070673"(response to interleukin-18)|rcsb pdb:5AR8|rcsb pdb:5J79|rcsb pdb:5J7B|rcsb pdb:5NG0|rcsb pdb:5NG2|rcsb pdb:5NG3|rcsb pdb:5W5J|rcsb pdb:5W5O|rcsb pdb:5YRN|rcsb pdb:6ES0|rcsb pdb:6FU5|rcsb pdb:6GFJ|rcsb pdb:6GGS|rcsb pdb:6HMX|rcsb pdb:6RN8|rcsb pdb:6RNA|rcsb pdb:6S1F|rcsb pdb:6SZE|rcsb pdb:6SZJ|rcsb pdb:6UL8|reactome:R-HSA-168638|reactome:R-HSA-202424|reactome:R-HSA-209543|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5689896|reactome:R-HSA-9020702|refseq:XP_005251149.1|dip:DIP-27518N	ensembl:ENSMUSG00000041849(gene)|ensembl:ENSMUST00000118365(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR011029(DEATH-like)|refseq:NP_001156610.1|refseq:XP_006520050.1|refseq:XP_006520052.1|refseq:XP_011243633.1|dip:DIP-61098N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/04	2017/08/10	rogid:vmVxb58HgNLVE3AgNkPsG0i7OXo9606	rogid:jaeeiO/Q/ktDII9YVZNnrsEDpLM10090	rigid:L9aumJiCD9bHT1DDcq+H7vicJEA	false	ha tag:c-c	sufficient binding region:95-1175|flag tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q13546	uniprotkb:Q9BX69	intact:EBI-358507|uniprotkb:A0AV89|uniprotkb:B2RAG1|uniprotkb:B4E3F9|uniprotkb:Q59H33|uniprotkb:Q13180|ensembl:ENSP00000259808	intact:EBI-14405242|ensembl:ENSP00000254691|uniprotkb:Q52LR2	psi-mi:ripk1_human(display_long)|uniprotkb:RIPK1(gene name)|psi-mi:RIPK1(display_short)|uniprotkb:RIP(gene name synonym)|uniprotkb:Cell death protein RIP(gene name synonym)|uniprotkb:RIP1(gene name synonym)|uniprotkb:Receptor-interacting protein 1(gene name synonym)	psi-mi:card6_human(display_long)|uniprotkb:CARD6(gene name)|psi-mi:CARD6(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Dufner et al. (2006)	pubmed:16418290|doi:10.1073/pnas.0510380103|imex:IM-23395	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15565135|imex:IM-23395-4|dip:DIP-197432E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003795.2|refseq:XP_005249514.2|dip:DIP-433N|ensembl:ENSG00000137275(gene)|ensembl:ENST00000259808(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0005123"(death receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008219"(cell death)|go:"GO:0010008"(endosome membrane)|go:"GO:0010940"(positive regulation of necrotic cell death)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060545"(positive regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0070105"(positive regulation of interleukin-6-mediated signaling pathway)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070513"(death domain binding)|go:"GO:0070926"("regulation of ATP:ADP antiporter activity")|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097342"(ripoptosome)|go:"GO:0097343"(ripoptosome assembly)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905206"(positive regulation of hydrogen peroxide-induced cell death)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000488(Death)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR025735|interpro:IPR037934|mint:Q13546|rcsb pdb:4ITH|rcsb pdb:4ITI|rcsb pdb:4ITJ|rcsb pdb:4NEU|rcsb pdb:5HX6|rcsb pdb:5TX5|rcsb pdb:5V7Z|rcsb pdb:6AC5|rcsb pdb:6C3E|rcsb pdb:6C4D|rcsb pdb:6HHO|rcsb pdb:6NW2|rcsb pdb:6NYH|rcsb pdb:6OCQ|rcsb pdb:6R5F|rcsb pdb:6RLN|reactome:R-HSA-140534|reactome:R-HSA-168927|reactome:R-HSA-1810476|reactome:R-HSA-2562578|reactome:R-HSA-3295583|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5675482|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-69416|reactome:R-HSA-75893|reactome:R-HSA-9013957|reactome:R-HSA-933543|reactome:R-HSA-937041|reactome:R-HSA-9679191|reactome:R-HSA-9686347|reactome:R-HSA-9693928|go:"GO:0070266"(necroptotic process)	ensembl:ENSG00000132357(gene)|ensembl:ENST00000254691(transcript)|go:"GO:0006915"(apoptotic process)|go:"GO:0042981"(regulation of apoptotic process)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR011029(DEATH-like)|refseq:NP_115976.2|dip:DIP-61097N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/04	2017/08/10	rogid:P1pQanTLVGi2Oic1QNeELpcdL2M9606	rogid:yV0IAFGVkhqPs4V4wah7p3gJd589606	rigid:mR9OgjxnV5RH0s3TW3eFWUdo02w	false	ha tag:c-c	sufficient binding region:282-949|flag tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P58801	uniprotkb:E9PWH2	intact:EBI-15565158|ensembl:ENSMUSP00000038833	intact:EBI-15565093|ensembl:ENSMUSP00000112833	psi-mi:ripk2_mouse(display_long)|uniprotkb:Ripk2(gene name)|psi-mi:Ripk2(display_short)|uniprotkb:Tyrosine-protein kinase RIPK2(gene name synonym)	psi-mi:e9pwh2_mouse(display_long)|uniprotkb:Card6(gene name)|psi-mi:Card6(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Dufner et al. (2006)	pubmed:16418290|doi:10.1073/pnas.0510380103|imex:IM-23395	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15565240|imex:IM-23395-5|dip:DIP-197434E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0070555"(response to interleukin-1)|go:"GO:0070671"(response to interleukin-12)|go:"GO:0070673"(response to interleukin-18)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071224"(cellular response to peptidoglycan)|go:"GO:0071225"(cellular response to muramyl dipeptide)|go:"GO:0089720"(caspase binding)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904417"(positive regulation of xenophagy)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|go:"GO:0070431"(nucleotide-binding oligomerization domain containing 2 signaling pathway)|interpro:IPR017322(Receptor-interacting serine/threonine-protein kinase 2)|interpro:IPR042149|reactome:R-MMU-168638|reactome:R-MMU-202424|reactome:R-MMU-209543|reactome:R-MMU-445989|reactome:R-MMU-450302|reactome:R-MMU-450321|reactome:R-MMU-5689896|reactome:R-MMU-9020702|ensembl:ENSMUSG00000041135(gene)|ensembl:ENSMUST00000037035(transcript)|go:"GO:0001961"(positive regulation of cytokine-mediated signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002827"(positive regulation of T-helper 1 type immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006915"(apoptotic process)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0030274"(LIM domain binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031982"(vesicle)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0045087"(innate immune response)|go:"GO:0045627"(positive regulation of T-helper 1 cell differentiation)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070427"(nucleotide-binding oligomerization domain containing 1 signaling pathway)|go:"GO:0033091"(positive regulation of immature T cell proliferation)|refseq:NP_620402.1	ensembl:ENSMUSG00000041849(gene)|ensembl:ENSMUST00000118365(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR011029(DEATH-like)|refseq:NP_001156610.1|refseq:XP_006520050.1|refseq:XP_006520052.1|refseq:XP_011243633.1|dip:DIP-61098N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/04	2017/08/10	rogid:QmvlF8wotovBBFsfzPVjJ/2HIpE10090	rogid:jaeeiO/Q/ktDII9YVZNnrsEDpLM10090	rigid:DABHgcomCaSEsz9dv1k3JuQPjSU	false	ha tag:c-c	sufficient binding region:95-1175|flag tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9BX69	uniprotkb:Q9BX69	intact:EBI-14405242|ensembl:ENSP00000254691|uniprotkb:Q52LR2	intact:EBI-14405242|ensembl:ENSP00000254691|uniprotkb:Q52LR2	psi-mi:card6_human(display_long)|uniprotkb:CARD6(gene name)|psi-mi:CARD6(display_short)	psi-mi:card6_human(display_long)|uniprotkb:CARD6(gene name)|psi-mi:CARD6(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Dufner et al. (2006)	pubmed:16418290|doi:10.1073/pnas.0510380103|imex:IM-23395	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15565263|imex:IM-23395-6|dip:DIP-197435E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000132357(gene)|ensembl:ENST00000254691(transcript)|go:"GO:0006915"(apoptotic process)|go:"GO:0042981"(regulation of apoptotic process)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR011029(DEATH-like)|refseq:NP_115976.2|dip:DIP-61097N	ensembl:ENSG00000132357(gene)|ensembl:ENST00000254691(transcript)|go:"GO:0006915"(apoptotic process)|go:"GO:0042981"(regulation of apoptotic process)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR011029(DEATH-like)|refseq:NP_115976.2|dip:DIP-61097N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/04	2017/08/10	rogid:yV0IAFGVkhqPs4V4wah7p3gJd589606	rogid:yV0IAFGVkhqPs4V4wah7p3gJd589606	rigid:iic16WTVQTbYkrMy1dbsXMKov+4	false	sufficient binding region:1-94|ha tag:c-c	flag tag:c-c|mutation disrupting interaction strength:33-33,31-31,30-30	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)