#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q02890 uniprotkb:P32628 intact:EBI-38139|uniprotkb:D6W3S1|ensemblfungi:YPL096W intact:EBI-14668|uniprotkb:D3DLL2|ensemblfungi:YEL037C psi-mi:png1_yeast(display_long)|uniprotkb:PNG1(gene name)|psi-mi:PNG1(display_short)|uniprotkb:YPL096W(locus name)|uniprotkb:"Peptide:N-glycanase 1"(gene name synonym) psi-mi:rad23_yeast(display_long)|uniprotkb:SYGP-ORF29(orf name)|uniprotkb:YEL037C(locus name)|uniprotkb:RAD23(gene name)|psi-mi:RAD23(display_short) psi-mi:"MI:0096"(pull down) Kim et al. (2006) pubmed:16401726|imex:IM-26194 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-16421925|imex:IM-26194-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_015229.1|sgd:S000006017|mint:Q02890|dip:DIP-4008N|ensemblfungi:YPL096W(gene)|ensemblfungi:YPL096W_mRNA(transcript)|go:"GO:0000224"("peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity")|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006516"(glycoprotein catabolic process)|go:"GO:0006517"(protein deglycosylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0097466"(ubiquitin-dependent glycoprotein ERAD pathway)|interpro:IPR002931(Transglutaminase-like)|interpro:IPR018325|interpro:IPR038765|rcsb pdb:1X3W|rcsb pdb:1X3Z|rcsb pdb:3ESW|reactome:R-SCE-532668 sgd:S000000763|ensemblfungi:YEL037C(gene)|ensemblfungi:YEL037C_mRNA(transcript)|go:"GO:0000111"(nucleotide-excision repair factor 2 complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006517"(protein deglycosylation)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070628"(proteasome binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR004806(UV excision repair protein Rad23)|reactome:R-SCE-5696395|reactome:R-SCE-532668|interpro:IPR009060(UBA-like)|interpro:IPR015360(XPC-binding domain)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR029071|interpro:IPR036353|rcsb pdb:1X3W|rcsb pdb:1X3Z|rcsb pdb:2NBU|rcsb pdb:2NBW|rcsb pdb:2QSF|rcsb pdb:2QSG|rcsb pdb:2QSH|rcsb pdb:3ESW|rcsb pdb:3M62|rcsb pdb:4YIR|rcsb pdb:6CFI|rcsb pdb:6UBF|interpro:IPR006636(Heat shock chaperonin-binding)|rcsb pdb:6UG1|rcsb pdb:6UIN|refseq:NP_010877.3|dip:DIP-1548N|mint:P32628 - - crc64:B3F0436DAB60B833 figure legend:Fig. 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/10/02 2017/10/02 rogid:pKkv7sWLSySdPtCV+BaTvg/mL+g559292 rogid:6Pl+Ctv8QBaoAY9m5xHv/qa/z7w559292 rigid:bBOFyL1GCvcqf9nTqeFkXGsZhAM false his tag:?-? glutathione s tranferase tag:n-n|sufficient binding region:77..77-398 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q02890 uniprotkb:P32628 intact:EBI-38139|uniprotkb:D6W3S1|ensemblfungi:YPL096W intact:EBI-14668|uniprotkb:D3DLL2|ensemblfungi:YEL037C psi-mi:png1_yeast(display_long)|uniprotkb:PNG1(gene name)|psi-mi:PNG1(display_short)|uniprotkb:YPL096W(locus name)|uniprotkb:"Peptide:N-glycanase 1"(gene name synonym) psi-mi:rad23_yeast(display_long)|uniprotkb:SYGP-ORF29(orf name)|uniprotkb:YEL037C(locus name)|uniprotkb:RAD23(gene name)|psi-mi:RAD23(display_short) psi-mi:"MI:0018"(two hybrid) Kim et al. (2006) pubmed:16401726|imex:IM-26194 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-16421956|imex:IM-26194-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_015229.1|sgd:S000006017|mint:Q02890|dip:DIP-4008N|ensemblfungi:YPL096W(gene)|ensemblfungi:YPL096W_mRNA(transcript)|go:"GO:0000224"("peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity")|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006516"(glycoprotein catabolic process)|go:"GO:0006517"(protein deglycosylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0097466"(ubiquitin-dependent glycoprotein ERAD pathway)|interpro:IPR002931(Transglutaminase-like)|interpro:IPR018325|interpro:IPR038765|rcsb pdb:1X3W|rcsb pdb:1X3Z|rcsb pdb:3ESW|reactome:R-SCE-532668 sgd:S000000763|ensemblfungi:YEL037C(gene)|ensemblfungi:YEL037C_mRNA(transcript)|go:"GO:0000111"(nucleotide-excision repair factor 2 complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006517"(protein deglycosylation)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070628"(proteasome binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR004806(UV excision repair protein Rad23)|reactome:R-SCE-5696395|reactome:R-SCE-532668|interpro:IPR009060(UBA-like)|interpro:IPR015360(XPC-binding domain)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR029071|interpro:IPR036353|rcsb pdb:1X3W|rcsb pdb:1X3Z|rcsb pdb:2NBU|rcsb pdb:2NBW|rcsb pdb:2QSF|rcsb pdb:2QSG|rcsb pdb:2QSH|rcsb pdb:3ESW|rcsb pdb:3M62|rcsb pdb:4YIR|rcsb pdb:6CFI|rcsb pdb:6UBF|interpro:IPR006636(Heat shock chaperonin-binding)|rcsb pdb:6UG1|rcsb pdb:6UIN|refseq:NP_010877.3|dip:DIP-1548N|mint:P32628 - - crc64:B3F0436DAB60B833 figure legend:Fig. 1D, 3A,3C, 4B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2017/10/02 2017/10/02 rogid:pKkv7sWLSySdPtCV+BaTvg/mL+g559292 rogid:6Pl+Ctv8QBaoAY9m5xHv/qa/z7w559292 rigid:bBOFyL1GCvcqf9nTqeFkXGsZhAM false mutation with no effect:218-218 mutation disrupting interaction strength:276-276|sufficient binding region:250..250-307(IPR015360)|mutation with no effect:183-183,392-392 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P38764 uniprotkb:P32628 intact:EBI-15913|uniprotkb:D3DKX4|ensemblfungi:YHR027C intact:EBI-14668|uniprotkb:D3DLL2|ensemblfungi:YEL037C psi-mi:rpn1_yeast(display_long)|uniprotkb:RPN1(gene name)|psi-mi:RPN1(display_short)|uniprotkb:HRD2(gene name synonym)|uniprotkb:NAS1(gene name synonym)|uniprotkb:RPD1(gene name synonym)|uniprotkb:Proteasome non-ATPase subunit 1(gene name synonym)|uniprotkb:HMG-CoA reductase degradation protein 2(gene name synonym)|uniprotkb:YHR027C(locus name) psi-mi:rad23_yeast(display_long)|uniprotkb:SYGP-ORF29(orf name)|uniprotkb:YEL037C(locus name)|uniprotkb:RAD23(gene name)|psi-mi:RAD23(display_short) psi-mi:"MI:0018"(two hybrid) Kim et al. (2006) pubmed:16401726|imex:IM-26194 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-16421974|imex:IM-26194-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_011892.1|sgd:S000001069|ensemblfungi:YHR027C(gene)|ensemblfungi:YHR027C_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|interpro:IPR040892|interpro:IPR041433|rcsb pdb:2N3T|rcsb pdb:2N3U|rcsb pdb:2N3V|rcsb pdb:2N3W|rcsb pdb:2NBW|rcsb pdb:3JCO|rcsb pdb:3JCP|rcsb pdb:4CR2|rcsb pdb:4CR3|rcsb pdb:4CR4|rcsb pdb:5A5B|rcsb pdb:5MPB|rcsb pdb:5MPC|rcsb pdb:5MPD|rcsb pdb:5MPE|rcsb pdb:5WVI|rcsb pdb:5WVK|rcsb pdb:6FVT|rcsb pdb:6FVX|rcsb pdb:6FVY|rcsb pdb:6J2C|rcsb pdb:6J2N|rcsb pdb:6J2Q|rcsb pdb:6J2X|rcsb pdb:6J30|reactome:R-SCE-1236978|reactome:R-SCE-174113|reactome:R-SCE-5668541|reactome:R-SCE-5687128|reactome:R-SCE-5689880|reactome:R-SCE-6798695|reactome:R-SCE-68949|reactome:R-SCE-69017|reactome:R-SCE-69601|reactome:R-SCE-75815|reactome:R-SCE-8854050|reactome:R-SCE-8948751|rcsb pdb:6FVU|reactome:R-SCE-983168|rcsb pdb:6FVV|rcsb pdb:6FVW|dip:DIP-2876N|mint:P38764 sgd:S000000763|ensemblfungi:YEL037C(gene)|ensemblfungi:YEL037C_mRNA(transcript)|go:"GO:0000111"(nucleotide-excision repair factor 2 complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006517"(protein deglycosylation)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070628"(proteasome binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR004806(UV excision repair protein Rad23)|reactome:R-SCE-5696395|reactome:R-SCE-532668|interpro:IPR009060(UBA-like)|interpro:IPR015360(XPC-binding domain)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR029071|interpro:IPR036353|rcsb pdb:1X3W|rcsb pdb:1X3Z|rcsb pdb:2NBU|rcsb pdb:2NBW|rcsb pdb:2QSF|rcsb pdb:2QSG|rcsb pdb:2QSH|rcsb pdb:3ESW|rcsb pdb:3M62|rcsb pdb:4YIR|rcsb pdb:6CFI|rcsb pdb:6UBF|interpro:IPR006636(Heat shock chaperonin-binding)|rcsb pdb:6UG1|rcsb pdb:6UIN|refseq:NP_010877.3|dip:DIP-1548N|mint:P32628 - crc64:B77954F4A998BA7C crc64:B3F0436DAB60B833 figure legend:Fig.4B, 3C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2017/10/02 2017/10/02 rogid:KZvwC6NNLC/jEW8wXPq2z+EFukY559292 rogid:6Pl+Ctv8QBaoAY9m5xHv/qa/z7w559292 rigid:UjsLKm358FsHhObFvd3NN0DGKUg false - mutation with no effect:276-276|mutation with no effect:183-183,392-392 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P14736 uniprotkb:P32628 intact:EBI-14766|ensemblfungi:YER162C|uniprotkb:D3DM70 intact:EBI-14668|uniprotkb:D3DLL2|ensemblfungi:YEL037C psi-mi:rad4_yeast(display_long)|uniprotkb:YER162C(locus name)|uniprotkb:RAD4(gene name)|psi-mi:RAD4(display_short) psi-mi:rad23_yeast(display_long)|uniprotkb:SYGP-ORF29(orf name)|uniprotkb:YEL037C(locus name)|uniprotkb:RAD23(gene name)|psi-mi:RAD23(display_short) psi-mi:"MI:0018"(two hybrid) Kim et al. (2006) pubmed:16401726|imex:IM-26194 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-16422319|imex:IM-26194-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) sgd:S000000964|ensemblfungi:YER162C(gene)|ensemblfungi:YER162C_mRNA(transcript)|go:"GO:0000111"(nucleotide-excision repair factor 2 complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006265"(DNA topological change)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006298"(mismatch repair)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0071942"(XPC complex)|go:"GO:1990165"(single-strand break-containing DNA binding)|interpro:IPR004583(DNA repair protein Rad4)|interpro:IPR018325|interpro:IPR018326|interpro:IPR018327|interpro:IPR018328|interpro:IPR036985|interpro:IPR038765|interpro:IPR042488|rcsb pdb:2M14|rcsb pdb:2QSF|rcsb pdb:2QSG|rcsb pdb:4YIR|rcsb pdb:6CFI|rcsb pdb:6UBF|rcsb pdb:6UG1|rcsb pdb:6UIN|rcsb pdb:2QSH|refseq:NP_011089.4|dip:DIP-1547N|mint:P14736 sgd:S000000763|ensemblfungi:YEL037C(gene)|ensemblfungi:YEL037C_mRNA(transcript)|go:"GO:0000111"(nucleotide-excision repair factor 2 complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006517"(protein deglycosylation)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070628"(proteasome binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR004806(UV excision repair protein Rad23)|reactome:R-SCE-5696395|reactome:R-SCE-532668|interpro:IPR009060(UBA-like)|interpro:IPR015360(XPC-binding domain)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR029071|interpro:IPR036353|rcsb pdb:1X3W|rcsb pdb:1X3Z|rcsb pdb:2NBU|rcsb pdb:2NBW|rcsb pdb:2QSF|rcsb pdb:2QSG|rcsb pdb:2QSH|rcsb pdb:3ESW|rcsb pdb:3M62|rcsb pdb:4YIR|rcsb pdb:6CFI|rcsb pdb:6UBF|interpro:IPR006636(Heat shock chaperonin-binding)|rcsb pdb:6UG1|rcsb pdb:6UIN|refseq:NP_010877.3|dip:DIP-1548N|mint:P32628 - crc64:788D3B6F580D2BF8 crc64:B3F0436DAB60B833 figure legend:Fig. 4B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2017/10/02 2017/10/03 rogid:oWnmog8oMzIGsGz5jdPXApX/o0I559292 rogid:6Pl+Ctv8QBaoAY9m5xHv/qa/z7w559292 rigid:KMu4F1Y5ZUzbjljqoqOIfkwKflg false - mutation with no effect:276-276 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P54860 uniprotkb:P32628 intact:EBI-20003|uniprotkb:D6VRG3|ensemblfungi:YDL190C intact:EBI-14668|uniprotkb:D3DLL2|ensemblfungi:YEL037C psi-mi:ufd2_yeast(display_long)|uniprotkb:UFD2(gene name)|psi-mi:UFD2(display_short)|uniprotkb:YDL190C(locus name)|uniprotkb:D1255(orf name)|uniprotkb:Ubiquitin fusion degradation protein 2(gene name synonym)|uniprotkb:Ubiquitin conjugation factor E4(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase UFD2(gene name synonym) psi-mi:rad23_yeast(display_long)|uniprotkb:SYGP-ORF29(orf name)|uniprotkb:YEL037C(locus name)|uniprotkb:RAD23(gene name)|psi-mi:RAD23(display_short) psi-mi:"MI:0018"(two hybrid) Kim et al. (2006) pubmed:16401726|imex:IM-26194 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-16422341|imex:IM-26194-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_010091.2|sgd:S000002349|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR003613(U box)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|go:"GO:0016567"(protein ubiquitination)|interpro:IPR019474|rcsb pdb:2QIZ|rcsb pdb:2QJ0|rcsb pdb:3M62|rcsb pdb:3M63|reactome:R-SCE-983168|ensemblfungi:YDL190C(gene)|ensemblfungi:YDL190C_mRNA(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|dip:DIP-5925N|mint:P54860 sgd:S000000763|ensemblfungi:YEL037C(gene)|ensemblfungi:YEL037C_mRNA(transcript)|go:"GO:0000111"(nucleotide-excision repair factor 2 complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006517"(protein deglycosylation)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070628"(proteasome binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR004806(UV excision repair protein Rad23)|reactome:R-SCE-5696395|reactome:R-SCE-532668|interpro:IPR009060(UBA-like)|interpro:IPR015360(XPC-binding domain)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR029071|interpro:IPR036353|rcsb pdb:1X3W|rcsb pdb:1X3Z|rcsb pdb:2NBU|rcsb pdb:2NBW|rcsb pdb:2QSF|rcsb pdb:2QSG|rcsb pdb:2QSH|rcsb pdb:3ESW|rcsb pdb:3M62|rcsb pdb:4YIR|rcsb pdb:6CFI|rcsb pdb:6UBF|interpro:IPR006636(Heat shock chaperonin-binding)|rcsb pdb:6UG1|rcsb pdb:6UIN|refseq:NP_010877.3|dip:DIP-1548N|mint:P32628 - crc64:877ACB59AC29634A crc64:B3F0436DAB60B833 figure legend:Fig. 4B, 5A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2017/10/02 2017/10/03 rogid:E8YkPPAM7RTsLwjUHSHNCjQWq9M559292 rogid:6Pl+Ctv8QBaoAY9m5xHv/qa/z7w559292 rigid:Q6LvJOSm9hsZcypwKZuQm7tF5aM false - mutation with no effect:276-276 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P32628 uniprotkb:P32628 intact:EBI-14668|uniprotkb:D3DLL2|ensemblfungi:YEL037C intact:EBI-14668|uniprotkb:D3DLL2|ensemblfungi:YEL037C psi-mi:rad23_yeast(display_long)|uniprotkb:SYGP-ORF29(orf name)|uniprotkb:YEL037C(locus name)|uniprotkb:RAD23(gene name)|psi-mi:RAD23(display_short) psi-mi:rad23_yeast(display_long)|uniprotkb:SYGP-ORF29(orf name)|uniprotkb:YEL037C(locus name)|uniprotkb:RAD23(gene name)|psi-mi:RAD23(display_short) psi-mi:"MI:0018"(two hybrid) Kim et al. (2006) pubmed:16401726|imex:IM-26194 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-16422348|imex:IM-26194-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) sgd:S000000763|ensemblfungi:YEL037C(gene)|ensemblfungi:YEL037C_mRNA(transcript)|go:"GO:0000111"(nucleotide-excision repair factor 2 complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006517"(protein deglycosylation)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070628"(proteasome binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR004806(UV excision repair protein Rad23)|reactome:R-SCE-5696395|reactome:R-SCE-532668|interpro:IPR009060(UBA-like)|interpro:IPR015360(XPC-binding domain)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR029071|interpro:IPR036353|rcsb pdb:1X3W|rcsb pdb:1X3Z|rcsb pdb:2NBU|rcsb pdb:2NBW|rcsb pdb:2QSF|rcsb pdb:2QSG|rcsb pdb:2QSH|rcsb pdb:3ESW|rcsb pdb:3M62|rcsb pdb:4YIR|rcsb pdb:6CFI|rcsb pdb:6UBF|interpro:IPR006636(Heat shock chaperonin-binding)|rcsb pdb:6UG1|rcsb pdb:6UIN|refseq:NP_010877.3|dip:DIP-1548N|mint:P32628 sgd:S000000763|ensemblfungi:YEL037C(gene)|ensemblfungi:YEL037C_mRNA(transcript)|go:"GO:0000111"(nucleotide-excision repair factor 2 complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006517"(protein deglycosylation)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070628"(proteasome binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR004806(UV excision repair protein Rad23)|reactome:R-SCE-5696395|reactome:R-SCE-532668|interpro:IPR009060(UBA-like)|interpro:IPR015360(XPC-binding domain)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR029071|interpro:IPR036353|rcsb pdb:1X3W|rcsb pdb:1X3Z|rcsb pdb:2NBU|rcsb pdb:2NBW|rcsb pdb:2QSF|rcsb pdb:2QSG|rcsb pdb:2QSH|rcsb pdb:3ESW|rcsb pdb:3M62|rcsb pdb:4YIR|rcsb pdb:6CFI|rcsb pdb:6UBF|interpro:IPR006636(Heat shock chaperonin-binding)|rcsb pdb:6UG1|rcsb pdb:6UIN|refseq:NP_010877.3|dip:DIP-1548N|mint:P32628 - crc64:B3F0436DAB60B833 crc64:B3F0436DAB60B833 figure legend:Fig. 4B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2017/10/02 2017/10/03 rogid:6Pl+Ctv8QBaoAY9m5xHv/qa/z7w559292 rogid:6Pl+Ctv8QBaoAY9m5xHv/qa/z7w559292 rigid:DPovvtkdbwZ4K3UAC39QSueDWpE false - mutation with no effect:276-276 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q02890 uniprotkb:P32628 intact:EBI-38139|uniprotkb:D6W3S1|ensemblfungi:YPL096W intact:EBI-14668|uniprotkb:D3DLL2|ensemblfungi:YEL037C psi-mi:png1_yeast(display_long)|uniprotkb:PNG1(gene name)|psi-mi:PNG1(display_short)|uniprotkb:YPL096W(locus name)|uniprotkb:"Peptide:N-glycanase 1"(gene name synonym) psi-mi:rad23_yeast(display_long)|uniprotkb:SYGP-ORF29(orf name)|uniprotkb:YEL037C(locus name)|uniprotkb:RAD23(gene name)|psi-mi:RAD23(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Kim et al. (2006) pubmed:16401726|imex:IM-26194 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-16422360|imex:IM-26194-13 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_015229.1|sgd:S000006017|mint:Q02890|dip:DIP-4008N|ensemblfungi:YPL096W(gene)|ensemblfungi:YPL096W_mRNA(transcript)|go:"GO:0000224"("peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity")|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006516"(glycoprotein catabolic process)|go:"GO:0006517"(protein deglycosylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0097466"(ubiquitin-dependent glycoprotein ERAD pathway)|interpro:IPR002931(Transglutaminase-like)|interpro:IPR018325|interpro:IPR038765|rcsb pdb:1X3W|rcsb pdb:1X3Z|rcsb pdb:3ESW|reactome:R-SCE-532668 sgd:S000000763|ensemblfungi:YEL037C(gene)|ensemblfungi:YEL037C_mRNA(transcript)|go:"GO:0000111"(nucleotide-excision repair factor 2 complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006517"(protein deglycosylation)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070628"(proteasome binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR004806(UV excision repair protein Rad23)|reactome:R-SCE-5696395|reactome:R-SCE-532668|interpro:IPR009060(UBA-like)|interpro:IPR015360(XPC-binding domain)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR029071|interpro:IPR036353|rcsb pdb:1X3W|rcsb pdb:1X3Z|rcsb pdb:2NBU|rcsb pdb:2NBW|rcsb pdb:2QSF|rcsb pdb:2QSG|rcsb pdb:2QSH|rcsb pdb:3ESW|rcsb pdb:3M62|rcsb pdb:4YIR|rcsb pdb:6CFI|rcsb pdb:6UBF|interpro:IPR006636(Heat shock chaperonin-binding)|rcsb pdb:6UG1|rcsb pdb:6UIN|refseq:NP_010877.3|dip:DIP-1548N|mint:P32628 - - crc64:B3F0436DAB60B833 figure legend:Fig. 4C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/10/02 2017/10/24 rogid:pKkv7sWLSySdPtCV+BaTvg/mL+g559292 rogid:6Pl+Ctv8QBaoAY9m5xHv/qa/z7w559292 rigid:bBOFyL1GCvcqf9nTqeFkXGsZhAM false his tag:?-? mutation disrupting interaction strength:276-276|flag tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P54860 uniprotkb:P32628 intact:EBI-20003|uniprotkb:D6VRG3|ensemblfungi:YDL190C intact:EBI-14668|uniprotkb:D3DLL2|ensemblfungi:YEL037C psi-mi:ufd2_yeast(display_long)|uniprotkb:UFD2(gene name)|psi-mi:UFD2(display_short)|uniprotkb:YDL190C(locus name)|uniprotkb:D1255(orf name)|uniprotkb:Ubiquitin fusion degradation protein 2(gene name synonym)|uniprotkb:Ubiquitin conjugation factor E4(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase UFD2(gene name synonym) psi-mi:rad23_yeast(display_long)|uniprotkb:SYGP-ORF29(orf name)|uniprotkb:YEL037C(locus name)|uniprotkb:RAD23(gene name)|psi-mi:RAD23(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Kim et al. (2006) pubmed:16401726|imex:IM-26194 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-16422377|imex:IM-26194-15 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_010091.2|sgd:S000002349|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR003613(U box)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|go:"GO:0016567"(protein ubiquitination)|interpro:IPR019474|rcsb pdb:2QIZ|rcsb pdb:2QJ0|rcsb pdb:3M62|rcsb pdb:3M63|reactome:R-SCE-983168|ensemblfungi:YDL190C(gene)|ensemblfungi:YDL190C_mRNA(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|dip:DIP-5925N|mint:P54860 sgd:S000000763|ensemblfungi:YEL037C(gene)|ensemblfungi:YEL037C_mRNA(transcript)|go:"GO:0000111"(nucleotide-excision repair factor 2 complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006517"(protein deglycosylation)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070628"(proteasome binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR004806(UV excision repair protein Rad23)|reactome:R-SCE-5696395|reactome:R-SCE-532668|interpro:IPR009060(UBA-like)|interpro:IPR015360(XPC-binding domain)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR029071|interpro:IPR036353|rcsb pdb:1X3W|rcsb pdb:1X3Z|rcsb pdb:2NBU|rcsb pdb:2NBW|rcsb pdb:2QSF|rcsb pdb:2QSG|rcsb pdb:2QSH|rcsb pdb:3ESW|rcsb pdb:3M62|rcsb pdb:4YIR|rcsb pdb:6CFI|rcsb pdb:6UBF|interpro:IPR006636(Heat shock chaperonin-binding)|rcsb pdb:6UG1|rcsb pdb:6UIN|refseq:NP_010877.3|dip:DIP-1548N|mint:P32628 - crc64:877ACB59AC29634A crc64:B3F0436DAB60B833 figure legend:Fig. 5B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/10/02 2017/11/02 rogid:E8YkPPAM7RTsLwjUHSHNCjQWq9M559292 rogid:6Pl+Ctv8QBaoAY9m5xHv/qa/z7w559292 rigid:Q6LvJOSm9hsZcypwKZuQm7tF5aM false myc tag:?-? flag tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot)