#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P0C6X7	uniprotkb:P0C6X7	intact:EBI-7843867|uniprotkb:Q6WGN0|uniprotkb:Q808C0|uniprotkb:P59641|uniprotkb:Q80BV8|uniprotkb:Q80BV7|intact:MINT-1487760|uniprotkb:Q80E51|uniprotkb:Q7T697	intact:EBI-7843867|uniprotkb:Q6WGN0|uniprotkb:Q808C0|uniprotkb:P59641|uniprotkb:Q80BV8|uniprotkb:Q80BV7|intact:MINT-1487760|uniprotkb:Q80E51|uniprotkb:Q7T697	psi-mi:r1ab_sars(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:1a-1b(orf name)|uniprotkb:ORF1ab polyprotein(gene name synonym)	psi-mi:r1ab_sars(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:1a-1b(orf name)|uniprotkb:ORF1ab polyprotein(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Saikatendu et al. (2005)	pubmed:16271890|doi:10.1016/j.str.2005.07.022|imex:IM-14229	taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus)	taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15559173|imex:IM-14229-1|dip:DIP-102957E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:5N19|rcsb pdb:5N5O|interpro:IPR002589(Appr-1-p processing)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR008740(Peptidase C30, Coronavirus endopeptidase)|interpro:IPR009461(Coronavirus NSP13)|interpro:IPR009466(NSP11)|interpro:IPR009469(RNA polymerase, N-terminal, coronaviral)|interpro:IPR013016(Peptidase C30/C16)|rcsb pdb:7LCP|rcsb pdb:7LCQ|rcsb pdb:5F22|rcsb pdb:5C8S|rcsb pdb:5C8T|rcsb pdb:5C8U|rcsb pdb:5E6J|go:"GO:0000175"(3'-5'-exoribonuclease activity)|go:"GO:0001172"(transcription, RNA-templated)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004386"(helicase activity)|go:"GO:0004482"("mRNA (guanine-N7-)-methyltransferase activity")|go:"GO:0004483"("mRNA (nucleoside-2'-O-)-methyltransferase activity")|go:"GO:0004519"(endonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019082"(viral protein processing)|go:"GO:0019083"(viral transcription)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0019785"(ISG15-specific protease activity)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0032574"(5'-3' RNA helicase activity)|go:"GO:0039501"(suppression by virus of host type I interferon production)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039547"(suppression by virus of host TRAF activity)|go:"GO:0039548"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity)|go:"GO:0039579"(suppression by virus of host ISG15-protein conjugation)|go:"GO:0039595"(induction by virus of catabolism of host mRNA)|go:"GO:0039604"(suppression by virus of host translation)|go:"GO:0039644"(suppression by virus of host NF-kappaB cascade)|go:"GO:0039648"(modulation by virus of host protein ubiquitination)|go:"GO:0039690"(positive stranded viral RNA replication)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039714"(cytoplasmic viral factory)|go:"GO:0039722"(suppression by virus of host toll-like receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0044172"(host cell endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0062243"(double membrane vesicle viral factory outer membrane)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0080009"(mRNA methylation)|go:"GO:0090503"(RNA phosphodiester bond hydrolysis, exonucleolytic)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|go:"GO:2000158"(positive regulation of ubiquitin-specific protease activity)|interpro:IPR032505|interpro:IPR032592|rcsb pdb:4TWW|rcsb pdb:4TWY|rcsb pdb:4WY3|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR043606|interpro:IPR043608|interpro:IPR043609|interpro:IPR043610|interpro:IPR043611|interpro:IPR043612|interpro:IPR043613|interpro:IPR043615|rcsb pdb:6LNQ|interpro:IPR043502|rcsb pdb:5NFY|rcsb pdb:4ZUH|rcsb pdb:5B6O|rcsb pdb:5C5N|rcsb pdb:5C5O|interpro:IPR043472|interpro:IPR043477|interpro:IPR043478|interpro:IPR044315|interpro:IPR044322|interpro:IPR044330|interpro:IPR044343|interpro:IPR044351|interpro:IPR044353|interpro:IPR044357|rcsb pdb:2GA6|rcsb pdb:1WOF|rcsb pdb:2QC2|rcsb pdb:1Z1J|rcsb pdb:2OZK|rcsb pdb:2Z3C|rcsb pdb:2RHB|rcsb pdb:2FAV|interpro:IPR018995|rcsb pdb:2GTB|interpro:IPR014828(Nsp7 replicase)|rcsb pdb:2GDT|interpro:IPR027352|rcsb pdb:2ALV|rcsb pdb:2JZF|rcsb pdb:2QIQ|rcsb pdb:2K87|rcsb pdb:2A5I|rcsb pdb:1UK4|interpro:IPR024375|rcsb pdb:1P9T|rcsb pdb:2D2D|rcsb pdb:3R24|rcsb pdb:2GT7|rcsb pdb:2AJ5|interpro:IPR027351|rcsb pdb:2G1F|rcsb pdb:2FE8|rcsb pdb:2GT8|rcsb pdb:1UK3|rcsb pdb:2H85|rcsb pdb:2BX3|rcsb pdb:1Q1X|rcsb pdb:2BX4|interpro:IPR021590|rcsb pdb:2Z9G|rcsb pdb:2ACF|rcsb pdb:1UK2|rcsb pdb:2GRI|rcsb pdb:2A5K|rcsb pdb:1SXF|rcsb pdb:2PWX|interpro:IPR014829(Nsp8 replicase)|interpro:IPR027417|interpro:IPR024358|rcsb pdb:3D62|rcsb pdb:2Z9J|rcsb pdb:2Z3E|rcsb pdb:2GZ8|rcsb pdb:1O5S|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|rcsb pdb:2AMD|rcsb pdb:2Z9K|rcsb pdb:1Q2W|rcsb pdb:2VJ1|rcsb pdb:2H2Z|rcsb pdb:2GX4|rcsb pdb:2AHM|rcsb pdb:1UJ1|rcsb pdb:2V6N|rcsb pdb:2HOB|rcsb pdb:1QZ8|rcsb pdb:2Z3D|rcsb pdb:1PA5|rcsb pdb:3EBN|rcsb pdb:2OP9|rcsb pdb:2DUC|rcsb pdb:2QCY|rcsb pdb:2JZD|rcsb pdb:2Q6G|rcsb pdb:1PUK|rcsb pdb:1UW7|rcsb pdb:2GZ9|rcsb pdb:1YSY|rcsb pdb:1Z1I|rcsb pdb:2JZE|rcsb pdb:2C3S|rcsb pdb:2XYQ|rcsb pdb:2XYV|rcsb pdb:2AMQ|rcsb pdb:3E9S|rcsb pdb:2IDY|rcsb pdb:2Z9L|rcsb pdb:2RNK|rcsb pdb:2A5A|interpro:IPR022733|rcsb pdb:2GZ7|rcsb pdb:2Z94|rcsb pdb:1P76|interpro:IPR014822(Nsp9 replicase)|rcsb pdb:2HSX|rcsb pdb:2FYG|rcsb pdb:2XYR|rcsb pdb:2G9T|interpro:IPR042515|rcsb pdb:6NUR|rcsb pdb:6NUS|interpro:IPR044367|interpro:IPR044371|interpro:IPR044374|interpro:IPR044389|interpro:IPR044401|interpro:IPR029063|interpro:IPR038030|interpro:IPR038083|interpro:IPR038123|interpro:IPR038166|interpro:IPR038400|interpro:IPR036333|interpro:IPR036499|interpro:IPR037204|interpro:IPR037227|interpro:IPR037230|interpro:IPR042570|rcsb pdb:6JYT|interpro:IPR043503|interpro:IPR043504|rcsb pdb:6W79|interpro:IPR043174|interpro:IPR043177|interpro:IPR043178|rcsb pdb:2K7X|reactome:R-HSA-9679504|reactome:R-HSA-9682706|reactome:R-HSA-9682708|reactome:R-HSA-9683439|reactome:R-HSA-9684325|refseq:NP_828849.2|rcsb pdb:6WCO	rcsb pdb:5N19|rcsb pdb:5N5O|interpro:IPR002589(Appr-1-p processing)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR008740(Peptidase C30, Coronavirus endopeptidase)|interpro:IPR009461(Coronavirus NSP13)|interpro:IPR009466(NSP11)|interpro:IPR009469(RNA polymerase, N-terminal, coronaviral)|interpro:IPR013016(Peptidase C30/C16)|rcsb pdb:7LCP|rcsb pdb:7LCQ|rcsb pdb:5F22|rcsb pdb:5C8S|rcsb pdb:5C8T|rcsb pdb:5C8U|rcsb pdb:5E6J|go:"GO:0000175"(3'-5'-exoribonuclease activity)|go:"GO:0001172"(transcription, RNA-templated)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004386"(helicase activity)|go:"GO:0004482"("mRNA (guanine-N7-)-methyltransferase activity")|go:"GO:0004483"("mRNA (nucleoside-2'-O-)-methyltransferase activity")|go:"GO:0004519"(endonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019082"(viral protein processing)|go:"GO:0019083"(viral transcription)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0019785"(ISG15-specific protease activity)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0032574"(5'-3' RNA helicase activity)|go:"GO:0039501"(suppression by virus of host type I interferon production)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039547"(suppression by virus of host TRAF activity)|go:"GO:0039548"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity)|go:"GO:0039579"(suppression by virus of host ISG15-protein conjugation)|go:"GO:0039595"(induction by virus of catabolism of host mRNA)|go:"GO:0039604"(suppression by virus of host translation)|go:"GO:0039644"(suppression by virus of host NF-kappaB cascade)|go:"GO:0039648"(modulation by virus of host protein ubiquitination)|go:"GO:0039690"(positive stranded viral RNA replication)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039714"(cytoplasmic viral factory)|go:"GO:0039722"(suppression by virus of host toll-like receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0044172"(host cell endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0062243"(double membrane vesicle viral factory outer membrane)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0080009"(mRNA methylation)|go:"GO:0090503"(RNA phosphodiester bond hydrolysis, exonucleolytic)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|go:"GO:2000158"(positive regulation of ubiquitin-specific protease activity)|interpro:IPR032505|interpro:IPR032592|rcsb pdb:4TWW|rcsb pdb:4TWY|rcsb pdb:4WY3|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR043606|interpro:IPR043608|interpro:IPR043609|interpro:IPR043610|interpro:IPR043611|interpro:IPR043612|interpro:IPR043613|interpro:IPR043615|rcsb pdb:6LNQ|interpro:IPR043502|rcsb pdb:5NFY|rcsb pdb:4ZUH|rcsb pdb:5B6O|rcsb pdb:5C5N|rcsb pdb:5C5O|interpro:IPR043472|interpro:IPR043477|interpro:IPR043478|interpro:IPR044315|interpro:IPR044322|interpro:IPR044330|interpro:IPR044343|interpro:IPR044351|interpro:IPR044353|interpro:IPR044357|rcsb pdb:2GA6|rcsb pdb:1WOF|rcsb pdb:2QC2|rcsb pdb:1Z1J|rcsb pdb:2OZK|rcsb pdb:2Z3C|rcsb pdb:2RHB|rcsb pdb:2FAV|interpro:IPR018995|rcsb pdb:2GTB|interpro:IPR014828(Nsp7 replicase)|rcsb pdb:2GDT|interpro:IPR027352|rcsb pdb:2ALV|rcsb pdb:2JZF|rcsb pdb:2QIQ|rcsb pdb:2K87|rcsb pdb:2A5I|rcsb pdb:1UK4|interpro:IPR024375|rcsb pdb:1P9T|rcsb pdb:2D2D|rcsb pdb:3R24|rcsb pdb:2GT7|rcsb pdb:2AJ5|interpro:IPR027351|rcsb pdb:2G1F|rcsb pdb:2FE8|rcsb pdb:2GT8|rcsb pdb:1UK3|rcsb pdb:2H85|rcsb pdb:2BX3|rcsb pdb:1Q1X|rcsb pdb:2BX4|interpro:IPR021590|rcsb pdb:2Z9G|rcsb pdb:2ACF|rcsb pdb:1UK2|rcsb pdb:2GRI|rcsb pdb:2A5K|rcsb pdb:1SXF|rcsb pdb:2PWX|interpro:IPR014829(Nsp8 replicase)|interpro:IPR027417|interpro:IPR024358|rcsb pdb:3D62|rcsb pdb:2Z9J|rcsb pdb:2Z3E|rcsb pdb:2GZ8|rcsb pdb:1O5S|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|rcsb pdb:2AMD|rcsb pdb:2Z9K|rcsb pdb:1Q2W|rcsb pdb:2VJ1|rcsb pdb:2H2Z|rcsb pdb:2GX4|rcsb pdb:2AHM|rcsb pdb:1UJ1|rcsb pdb:2V6N|rcsb pdb:2HOB|rcsb pdb:1QZ8|rcsb pdb:2Z3D|rcsb pdb:1PA5|rcsb pdb:3EBN|rcsb pdb:2OP9|rcsb pdb:2DUC|rcsb pdb:2QCY|rcsb pdb:2JZD|rcsb pdb:2Q6G|rcsb pdb:1PUK|rcsb pdb:1UW7|rcsb pdb:2GZ9|rcsb pdb:1YSY|rcsb pdb:1Z1I|rcsb pdb:2JZE|rcsb pdb:2C3S|rcsb pdb:2XYQ|rcsb pdb:2XYV|rcsb pdb:2AMQ|rcsb pdb:3E9S|rcsb pdb:2IDY|rcsb pdb:2Z9L|rcsb pdb:2RNK|rcsb pdb:2A5A|interpro:IPR022733|rcsb pdb:2GZ7|rcsb pdb:2Z94|rcsb pdb:1P76|interpro:IPR014822(Nsp9 replicase)|rcsb pdb:2HSX|rcsb pdb:2FYG|rcsb pdb:2XYR|rcsb pdb:2G9T|interpro:IPR042515|rcsb pdb:6NUR|rcsb pdb:6NUS|interpro:IPR044367|interpro:IPR044371|interpro:IPR044374|interpro:IPR044389|interpro:IPR044401|interpro:IPR029063|interpro:IPR038030|interpro:IPR038083|interpro:IPR038123|interpro:IPR038166|interpro:IPR038400|interpro:IPR036333|interpro:IPR036499|interpro:IPR037204|interpro:IPR037227|interpro:IPR037230|interpro:IPR042570|rcsb pdb:6JYT|interpro:IPR043503|interpro:IPR043504|rcsb pdb:6W79|interpro:IPR043174|interpro:IPR043177|interpro:IPR043178|rcsb pdb:2K7X|reactome:R-HSA-9679504|reactome:R-HSA-9682706|reactome:R-HSA-9682708|reactome:R-HSA-9683439|reactome:R-HSA-9684325|refseq:NP_828849.2|rcsb pdb:6WCO	psi-mi:"MI:0465"(dip)	crc64:E6504CAFDC36BC09|comment:mint|function:"The replicase polyprotein of coronaviruses is a multifunctional protein: it contains the activities necessary for the transcription of negative stranded RNA, leader RNA, subgenomic mRNAs and progeny virion RNA as well as proteinases responsible for the cleavage of the polyprotein into functional products"|function:"The papain-like proteinase (PL-PRO) is responsible for the cleavages located at the N-terminus of replicase polyprotein. Activity of PL-PRO is dependent on zinc"|function:"The main proteinase 3CL-PRO is responsible for the majority of cleavages as it cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-|-[SGACN]. Inhibited by the substrate-analog Cbz-Val-Asn-Ser-Thr-Leu-Gln-CMK (By similarity). Also contains an ADP-ribose-1''-phosphate (ADRP)-binding function"|function:"The helicase which contains a zinc finger structure displays RNA and DNA duplex-unwinding activities with 5' to 3' polarity. Its ATPase activity is strongly stimulated by poly(U), poly(dT), poly(C), poly(dA), but not by poly(G). Activity of helicase is dependent on magnesium"|function:The exoribonuclease acts on both ssRNA and dsRNA in a 3' to 5' direction|function:Nsp7-nsp8 hexadecamer may possibly confer processivity to the polymerase, maybe by binding to dsRNA or by producing primers utilized by the latter|function:Nsp9 is a ssRNA-binding protein|function:"NendoU is a Mn(2+)-dependent, uridylate-specific enzyme, which leaves 2'-3'-cyclic phosphates 5' to the cleaved bond"	crc64:E6504CAFDC36BC09|comment:mint|function:"The replicase polyprotein of coronaviruses is a multifunctional protein: it contains the activities necessary for the transcription of negative stranded RNA, leader RNA, subgenomic mRNAs and progeny virion RNA as well as proteinases responsible for the cleavage of the polyprotein into functional products"|function:"The papain-like proteinase (PL-PRO) is responsible for the cleavages located at the N-terminus of replicase polyprotein. Activity of PL-PRO is dependent on zinc"|function:"The main proteinase 3CL-PRO is responsible for the majority of cleavages as it cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-|-[SGACN]. Inhibited by the substrate-analog Cbz-Val-Asn-Ser-Thr-Leu-Gln-CMK (By similarity). Also contains an ADP-ribose-1''-phosphate (ADRP)-binding function"|function:"The helicase which contains a zinc finger structure displays RNA and DNA duplex-unwinding activities with 5' to 3' polarity. Its ATPase activity is strongly stimulated by poly(U), poly(dT), poly(C), poly(dA), but not by poly(G). Activity of helicase is dependent on magnesium"|function:The exoribonuclease acts on both ssRNA and dsRNA in a 3' to 5' direction|function:Nsp7-nsp8 hexadecamer may possibly confer processivity to the polymerase, maybe by binding to dsRNA or by producing primers utilized by the latter|function:Nsp9 is a ssRNA-binding protein|function:"NendoU is a Mn(2+)-dependent, uridylate-specific enzyme, which leaves 2'-3'-cyclic phosphates 5' to the cleaved bond"	dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/04	2017/08/10	rogid:kCQUYVz2xMpwIvb+ZIpnIrNl9GI694009	rogid:kCQUYVz2xMpwIvb+ZIpnIrNl9GI694009	rigid:rIWfOmlTgRNSG1OxgEym+zDeKGg	false	binding-associated region:184-365	binding-associated region:184-365	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0C6X7	uniprotkb:P0C6X7	intact:EBI-7843867|uniprotkb:Q6WGN0|uniprotkb:Q808C0|uniprotkb:P59641|uniprotkb:Q80BV8|uniprotkb:Q80BV7|intact:MINT-1487760|uniprotkb:Q80E51|uniprotkb:Q7T697	intact:EBI-7843867|uniprotkb:Q6WGN0|uniprotkb:Q808C0|uniprotkb:P59641|uniprotkb:Q80BV8|uniprotkb:Q80BV7|intact:MINT-1487760|uniprotkb:Q80E51|uniprotkb:Q7T697	psi-mi:r1ab_sars(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:1a-1b(orf name)|uniprotkb:ORF1ab polyprotein(gene name synonym)	psi-mi:r1ab_sars(display_long)|uniprotkb:rep(gene name)|psi-mi:rep(display_short)|uniprotkb:1a-1b(orf name)|uniprotkb:ORF1ab polyprotein(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Saikatendu et al. (2005)	pubmed:16271890|doi:10.1016/j.str.2005.07.022|imex:IM-14229	taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus)	taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15559192|imex:IM-14229-2|dip:DIP-102957E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:5N19|rcsb pdb:5N5O|interpro:IPR002589(Appr-1-p processing)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR008740(Peptidase C30, Coronavirus endopeptidase)|interpro:IPR009461(Coronavirus NSP13)|interpro:IPR009466(NSP11)|interpro:IPR009469(RNA polymerase, N-terminal, coronaviral)|interpro:IPR013016(Peptidase C30/C16)|rcsb pdb:7LCP|rcsb pdb:7LCQ|rcsb pdb:5F22|rcsb pdb:5C8S|rcsb pdb:5C8T|rcsb pdb:5C8U|rcsb pdb:5E6J|go:"GO:0000175"(3'-5'-exoribonuclease activity)|go:"GO:0001172"(transcription, RNA-templated)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004386"(helicase activity)|go:"GO:0004482"("mRNA (guanine-N7-)-methyltransferase activity")|go:"GO:0004483"("mRNA (nucleoside-2'-O-)-methyltransferase activity")|go:"GO:0004519"(endonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019082"(viral protein processing)|go:"GO:0019083"(viral transcription)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0019785"(ISG15-specific protease activity)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0032574"(5'-3' RNA helicase activity)|go:"GO:0039501"(suppression by virus of host type I interferon production)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039547"(suppression by virus of host TRAF activity)|go:"GO:0039548"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity)|go:"GO:0039579"(suppression by virus of host ISG15-protein conjugation)|go:"GO:0039595"(induction by virus of catabolism of host mRNA)|go:"GO:0039604"(suppression by virus of host translation)|go:"GO:0039644"(suppression by virus of host NF-kappaB cascade)|go:"GO:0039648"(modulation by virus of host protein ubiquitination)|go:"GO:0039690"(positive stranded viral RNA replication)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039714"(cytoplasmic viral factory)|go:"GO:0039722"(suppression by virus of host toll-like receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0044172"(host cell endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0062243"(double membrane vesicle viral factory outer membrane)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0080009"(mRNA methylation)|go:"GO:0090503"(RNA phosphodiester bond hydrolysis, exonucleolytic)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|go:"GO:2000158"(positive regulation of ubiquitin-specific protease activity)|interpro:IPR032505|interpro:IPR032592|rcsb pdb:4TWW|rcsb pdb:4TWY|rcsb pdb:4WY3|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR043606|interpro:IPR043608|interpro:IPR043609|interpro:IPR043610|interpro:IPR043611|interpro:IPR043612|interpro:IPR043613|interpro:IPR043615|rcsb pdb:6LNQ|interpro:IPR043502|rcsb pdb:5NFY|rcsb pdb:4ZUH|rcsb pdb:5B6O|rcsb pdb:5C5N|rcsb pdb:5C5O|interpro:IPR043472|interpro:IPR043477|interpro:IPR043478|interpro:IPR044315|interpro:IPR044322|interpro:IPR044330|interpro:IPR044343|interpro:IPR044351|interpro:IPR044353|interpro:IPR044357|rcsb pdb:2GA6|rcsb pdb:1WOF|rcsb pdb:2QC2|rcsb pdb:1Z1J|rcsb pdb:2OZK|rcsb pdb:2Z3C|rcsb pdb:2RHB|rcsb pdb:2FAV|interpro:IPR018995|rcsb pdb:2GTB|interpro:IPR014828(Nsp7 replicase)|rcsb pdb:2GDT|interpro:IPR027352|rcsb pdb:2ALV|rcsb pdb:2JZF|rcsb pdb:2QIQ|rcsb pdb:2K87|rcsb pdb:2A5I|rcsb pdb:1UK4|interpro:IPR024375|rcsb pdb:1P9T|rcsb pdb:2D2D|rcsb pdb:3R24|rcsb pdb:2GT7|rcsb pdb:2AJ5|interpro:IPR027351|rcsb pdb:2G1F|rcsb pdb:2FE8|rcsb pdb:2GT8|rcsb pdb:1UK3|rcsb pdb:2H85|rcsb pdb:2BX3|rcsb pdb:1Q1X|rcsb pdb:2BX4|interpro:IPR021590|rcsb pdb:2Z9G|rcsb pdb:2ACF|rcsb pdb:1UK2|rcsb pdb:2GRI|rcsb pdb:2A5K|rcsb pdb:1SXF|rcsb pdb:2PWX|interpro:IPR014829(Nsp8 replicase)|interpro:IPR027417|interpro:IPR024358|rcsb pdb:3D62|rcsb pdb:2Z9J|rcsb pdb:2Z3E|rcsb pdb:2GZ8|rcsb pdb:1O5S|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|rcsb pdb:2AMD|rcsb pdb:2Z9K|rcsb pdb:1Q2W|rcsb pdb:2VJ1|rcsb pdb:2H2Z|rcsb pdb:2GX4|rcsb pdb:2AHM|rcsb pdb:1UJ1|rcsb pdb:2V6N|rcsb pdb:2HOB|rcsb pdb:1QZ8|rcsb pdb:2Z3D|rcsb pdb:1PA5|rcsb pdb:3EBN|rcsb pdb:2OP9|rcsb pdb:2DUC|rcsb pdb:2QCY|rcsb pdb:2JZD|rcsb pdb:2Q6G|rcsb pdb:1PUK|rcsb pdb:1UW7|rcsb pdb:2GZ9|rcsb pdb:1YSY|rcsb pdb:1Z1I|rcsb pdb:2JZE|rcsb pdb:2C3S|rcsb pdb:2XYQ|rcsb pdb:2XYV|rcsb pdb:2AMQ|rcsb pdb:3E9S|rcsb pdb:2IDY|rcsb pdb:2Z9L|rcsb pdb:2RNK|rcsb pdb:2A5A|interpro:IPR022733|rcsb pdb:2GZ7|rcsb pdb:2Z94|rcsb pdb:1P76|interpro:IPR014822(Nsp9 replicase)|rcsb pdb:2HSX|rcsb pdb:2FYG|rcsb pdb:2XYR|rcsb pdb:2G9T|interpro:IPR042515|rcsb pdb:6NUR|rcsb pdb:6NUS|interpro:IPR044367|interpro:IPR044371|interpro:IPR044374|interpro:IPR044389|interpro:IPR044401|interpro:IPR029063|interpro:IPR038030|interpro:IPR038083|interpro:IPR038123|interpro:IPR038166|interpro:IPR038400|interpro:IPR036333|interpro:IPR036499|interpro:IPR037204|interpro:IPR037227|interpro:IPR037230|interpro:IPR042570|rcsb pdb:6JYT|interpro:IPR043503|interpro:IPR043504|rcsb pdb:6W79|interpro:IPR043174|interpro:IPR043177|interpro:IPR043178|rcsb pdb:2K7X|reactome:R-HSA-9679504|reactome:R-HSA-9682706|reactome:R-HSA-9682708|reactome:R-HSA-9683439|reactome:R-HSA-9684325|refseq:NP_828849.2|rcsb pdb:6WCO	rcsb pdb:5N19|rcsb pdb:5N5O|interpro:IPR002589(Appr-1-p processing)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR008740(Peptidase C30, Coronavirus endopeptidase)|interpro:IPR009461(Coronavirus NSP13)|interpro:IPR009466(NSP11)|interpro:IPR009469(RNA polymerase, N-terminal, coronaviral)|interpro:IPR013016(Peptidase C30/C16)|rcsb pdb:7LCP|rcsb pdb:7LCQ|rcsb pdb:5F22|rcsb pdb:5C8S|rcsb pdb:5C8T|rcsb pdb:5C8U|rcsb pdb:5E6J|go:"GO:0000175"(3'-5'-exoribonuclease activity)|go:"GO:0001172"(transcription, RNA-templated)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004386"(helicase activity)|go:"GO:0004482"("mRNA (guanine-N7-)-methyltransferase activity")|go:"GO:0004483"("mRNA (nucleoside-2'-O-)-methyltransferase activity")|go:"GO:0004519"(endonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019082"(viral protein processing)|go:"GO:0019083"(viral transcription)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0019785"(ISG15-specific protease activity)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0032574"(5'-3' RNA helicase activity)|go:"GO:0039501"(suppression by virus of host type I interferon production)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039547"(suppression by virus of host TRAF activity)|go:"GO:0039548"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity)|go:"GO:0039579"(suppression by virus of host ISG15-protein conjugation)|go:"GO:0039595"(induction by virus of catabolism of host mRNA)|go:"GO:0039604"(suppression by virus of host translation)|go:"GO:0039644"(suppression by virus of host NF-kappaB cascade)|go:"GO:0039648"(modulation by virus of host protein ubiquitination)|go:"GO:0039690"(positive stranded viral RNA replication)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039714"(cytoplasmic viral factory)|go:"GO:0039722"(suppression by virus of host toll-like receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0044172"(host cell endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0062243"(double membrane vesicle viral factory outer membrane)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0080009"(mRNA methylation)|go:"GO:0090503"(RNA phosphodiester bond hydrolysis, exonucleolytic)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|go:"GO:2000158"(positive regulation of ubiquitin-specific protease activity)|interpro:IPR032505|interpro:IPR032592|rcsb pdb:4TWW|rcsb pdb:4TWY|rcsb pdb:4WY3|interpro:IPR001205(RNA-directed RNA polymerase, P3D protein)|interpro:IPR043606|interpro:IPR043608|interpro:IPR043609|interpro:IPR043610|interpro:IPR043611|interpro:IPR043612|interpro:IPR043613|interpro:IPR043615|rcsb pdb:6LNQ|interpro:IPR043502|rcsb pdb:5NFY|rcsb pdb:4ZUH|rcsb pdb:5B6O|rcsb pdb:5C5N|rcsb pdb:5C5O|interpro:IPR043472|interpro:IPR043477|interpro:IPR043478|interpro:IPR044315|interpro:IPR044322|interpro:IPR044330|interpro:IPR044343|interpro:IPR044351|interpro:IPR044353|interpro:IPR044357|rcsb pdb:2GA6|rcsb pdb:1WOF|rcsb pdb:2QC2|rcsb pdb:1Z1J|rcsb pdb:2OZK|rcsb pdb:2Z3C|rcsb pdb:2RHB|rcsb pdb:2FAV|interpro:IPR018995|rcsb pdb:2GTB|interpro:IPR014828(Nsp7 replicase)|rcsb pdb:2GDT|interpro:IPR027352|rcsb pdb:2ALV|rcsb pdb:2JZF|rcsb pdb:2QIQ|rcsb pdb:2K87|rcsb pdb:2A5I|rcsb pdb:1UK4|interpro:IPR024375|rcsb pdb:1P9T|rcsb pdb:2D2D|rcsb pdb:3R24|rcsb pdb:2GT7|rcsb pdb:2AJ5|interpro:IPR027351|rcsb pdb:2G1F|rcsb pdb:2FE8|rcsb pdb:2GT8|rcsb pdb:1UK3|rcsb pdb:2H85|rcsb pdb:2BX3|rcsb pdb:1Q1X|rcsb pdb:2BX4|interpro:IPR021590|rcsb pdb:2Z9G|rcsb pdb:2ACF|rcsb pdb:1UK2|rcsb pdb:2GRI|rcsb pdb:2A5K|rcsb pdb:1SXF|rcsb pdb:2PWX|interpro:IPR014829(Nsp8 replicase)|interpro:IPR027417|interpro:IPR024358|rcsb pdb:3D62|rcsb pdb:2Z9J|rcsb pdb:2Z3E|rcsb pdb:2GZ8|rcsb pdb:1O5S|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|rcsb pdb:2AMD|rcsb pdb:2Z9K|rcsb pdb:1Q2W|rcsb pdb:2VJ1|rcsb pdb:2H2Z|rcsb pdb:2GX4|rcsb pdb:2AHM|rcsb pdb:1UJ1|rcsb pdb:2V6N|rcsb pdb:2HOB|rcsb pdb:1QZ8|rcsb pdb:2Z3D|rcsb pdb:1PA5|rcsb pdb:3EBN|rcsb pdb:2OP9|rcsb pdb:2DUC|rcsb pdb:2QCY|rcsb pdb:2JZD|rcsb pdb:2Q6G|rcsb pdb:1PUK|rcsb pdb:1UW7|rcsb pdb:2GZ9|rcsb pdb:1YSY|rcsb pdb:1Z1I|rcsb pdb:2JZE|rcsb pdb:2C3S|rcsb pdb:2XYQ|rcsb pdb:2XYV|rcsb pdb:2AMQ|rcsb pdb:3E9S|rcsb pdb:2IDY|rcsb pdb:2Z9L|rcsb pdb:2RNK|rcsb pdb:2A5A|interpro:IPR022733|rcsb pdb:2GZ7|rcsb pdb:2Z94|rcsb pdb:1P76|interpro:IPR014822(Nsp9 replicase)|rcsb pdb:2HSX|rcsb pdb:2FYG|rcsb pdb:2XYR|rcsb pdb:2G9T|interpro:IPR042515|rcsb pdb:6NUR|rcsb pdb:6NUS|interpro:IPR044367|interpro:IPR044371|interpro:IPR044374|interpro:IPR044389|interpro:IPR044401|interpro:IPR029063|interpro:IPR038030|interpro:IPR038083|interpro:IPR038123|interpro:IPR038166|interpro:IPR038400|interpro:IPR036333|interpro:IPR036499|interpro:IPR037204|interpro:IPR037227|interpro:IPR037230|interpro:IPR042570|rcsb pdb:6JYT|interpro:IPR043503|interpro:IPR043504|rcsb pdb:6W79|interpro:IPR043174|interpro:IPR043177|interpro:IPR043178|rcsb pdb:2K7X|reactome:R-HSA-9679504|reactome:R-HSA-9682706|reactome:R-HSA-9682708|reactome:R-HSA-9683439|reactome:R-HSA-9684325|refseq:NP_828849.2|rcsb pdb:6WCO	psi-mi:"MI:0465"(dip)	crc64:E6504CAFDC36BC09|comment:mint|function:"The replicase polyprotein of coronaviruses is a multifunctional protein: it contains the activities necessary for the transcription of negative stranded RNA, leader RNA, subgenomic mRNAs and progeny virion RNA as well as proteinases responsible for the cleavage of the polyprotein into functional products"|function:"The papain-like proteinase (PL-PRO) is responsible for the cleavages located at the N-terminus of replicase polyprotein. Activity of PL-PRO is dependent on zinc"|function:"The main proteinase 3CL-PRO is responsible for the majority of cleavages as it cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-|-[SGACN]. Inhibited by the substrate-analog Cbz-Val-Asn-Ser-Thr-Leu-Gln-CMK (By similarity). Also contains an ADP-ribose-1''-phosphate (ADRP)-binding function"|function:"The helicase which contains a zinc finger structure displays RNA and DNA duplex-unwinding activities with 5' to 3' polarity. Its ATPase activity is strongly stimulated by poly(U), poly(dT), poly(C), poly(dA), but not by poly(G). Activity of helicase is dependent on magnesium"|function:The exoribonuclease acts on both ssRNA and dsRNA in a 3' to 5' direction|function:Nsp7-nsp8 hexadecamer may possibly confer processivity to the polymerase, maybe by binding to dsRNA or by producing primers utilized by the latter|function:Nsp9 is a ssRNA-binding protein|function:"NendoU is a Mn(2+)-dependent, uridylate-specific enzyme, which leaves 2'-3'-cyclic phosphates 5' to the cleaved bond"	crc64:E6504CAFDC36BC09|comment:mint|function:"The replicase polyprotein of coronaviruses is a multifunctional protein: it contains the activities necessary for the transcription of negative stranded RNA, leader RNA, subgenomic mRNAs and progeny virion RNA as well as proteinases responsible for the cleavage of the polyprotein into functional products"|function:"The papain-like proteinase (PL-PRO) is responsible for the cleavages located at the N-terminus of replicase polyprotein. Activity of PL-PRO is dependent on zinc"|function:"The main proteinase 3CL-PRO is responsible for the majority of cleavages as it cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-|-[SGACN]. Inhibited by the substrate-analog Cbz-Val-Asn-Ser-Thr-Leu-Gln-CMK (By similarity). Also contains an ADP-ribose-1''-phosphate (ADRP)-binding function"|function:"The helicase which contains a zinc finger structure displays RNA and DNA duplex-unwinding activities with 5' to 3' polarity. Its ATPase activity is strongly stimulated by poly(U), poly(dT), poly(C), poly(dA), but not by poly(G). Activity of helicase is dependent on magnesium"|function:The exoribonuclease acts on both ssRNA and dsRNA in a 3' to 5' direction|function:Nsp7-nsp8 hexadecamer may possibly confer processivity to the polymerase, maybe by binding to dsRNA or by producing primers utilized by the latter|function:Nsp9 is a ssRNA-binding protein|function:"NendoU is a Mn(2+)-dependent, uridylate-specific enzyme, which leaves 2'-3'-cyclic phosphates 5' to the cleaved bond"	dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/04	2017/08/10	rogid:kCQUYVz2xMpwIvb+ZIpnIrNl9GI694009	rogid:kCQUYVz2xMpwIvb+ZIpnIrNl9GI694009	rigid:rIWfOmlTgRNSG1OxgEym+zDeKGg	false	binding-associated region:184-365	binding-associated region:184-365	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)