#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P78380	uniprotkb:P78380	intact:EBI-7151999|ensembl:ENSP00000309124|uniprotkb:G3V1I4|uniprotkb:Q2PP00|intact:MINT-1343572|uniprotkb:Q7Z484|uniprotkb:B4DI48|uniprotkb:A8K7V9	intact:EBI-7151999|ensembl:ENSP00000309124|uniprotkb:G3V1I4|uniprotkb:Q2PP00|intact:MINT-1343572|uniprotkb:Q7Z484|uniprotkb:B4DI48|uniprotkb:A8K7V9	psi-mi:olr1_human(display_long)|uniprotkb:OLR1(gene name)|psi-mi:OLR1(display_short)|uniprotkb:LOX1(gene name synonym)|uniprotkb:Lectin-type oxidized LDL receptor 1(gene name synonym)|uniprotkb:Lectin-like oxidized LDL receptor 1(gene name synonym)|uniprotkb:CLEC8A(gene name synonym)|uniprotkb:C-type lectin domain family 8 member A(gene name synonym)	psi-mi:olr1_human(display_long)|uniprotkb:OLR1(gene name)|psi-mi:OLR1(display_short)|uniprotkb:LOX1(gene name synonym)|uniprotkb:Lectin-type oxidized LDL receptor 1(gene name synonym)|uniprotkb:Lectin-like oxidized LDL receptor 1(gene name synonym)|uniprotkb:CLEC8A(gene name synonym)|uniprotkb:C-type lectin domain family 8 member A(gene name synonym)	psi-mi:"MI:0808"(comigration in sds page)	Ohki et al. (2005)	pubmed:15939022|doi:10.1016/j.str.2005.03.016|imex:IM-14202	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0195"(covalent binding)	psi-mi:"MI:0465"(DIP)	intact:EBI-15553168|imex:IM-14202-1|dip:DIP-102914E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000173391(gene)|ensembl:ENST00000309539(transcript)|go:"GO:0002376"(immune system process)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0008015"(blood circulation)|go:"GO:0008219"(cell death)|go:"GO:0016020"(membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0045121"(membrane raft)|go:"GO:0070821"(tertiary granule membrane)|interpro:IPR001304(C-type lectin)|interpro:IPR013600(Ly49-like N-terminal)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR033992|mint:P78380|rcsb pdb:1YPO|rcsb pdb:1YPQ|rcsb pdb:1YPU|rcsb pdb:1YXJ|rcsb pdb:1YXK|rcsb pdb:3VLG|rcsb pdb:6TL7|rcsb pdb:6TL9|rcsb pdb:6TLA|reactome:R-HSA-202733|reactome:R-HSA-6798695|refseq:NP_001166104.1|refseq:NP_002534.1|refseq:NP_001166103.1|dip:DIP-42040N	ensembl:ENSG00000173391(gene)|ensembl:ENST00000309539(transcript)|go:"GO:0002376"(immune system process)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0008015"(blood circulation)|go:"GO:0008219"(cell death)|go:"GO:0016020"(membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0045121"(membrane raft)|go:"GO:0070821"(tertiary granule membrane)|interpro:IPR001304(C-type lectin)|interpro:IPR013600(Ly49-like N-terminal)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR033992|mint:P78380|rcsb pdb:1YPO|rcsb pdb:1YPQ|rcsb pdb:1YPU|rcsb pdb:1YXJ|rcsb pdb:1YXK|rcsb pdb:3VLG|rcsb pdb:6TL7|rcsb pdb:6TL9|rcsb pdb:6TLA|reactome:R-HSA-202733|reactome:R-HSA-6798695|refseq:NP_001166104.1|refseq:NP_002534.1|refseq:NP_001166103.1|dip:DIP-42040N	psi-mi:"MI:0465"(dip)	function:"Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria"|comment:mint|function:"Defects in OLR1 may be a cause of susceptibility to myocardial infarction [MIM:608557]"|function:"Defects in OLR1 may be associated with susceptibility to Alzheimer disease (AD) [MIM:104300]. Involvement in AD is however unclear: according to some authors (Ref.10, Ref.13 and Ref.18), variations in OLR1 modify the risk of AD, while according to other (Ref.15 and Ref.16), they do not"	function:"Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria"|comment:mint|function:"Defects in OLR1 may be a cause of susceptibility to myocardial infarction [MIM:608557]"|function:"Defects in OLR1 may be associated with susceptibility to Alzheimer disease (AD) [MIM:104300]. Involvement in AD is however unclear: according to some authors (Ref.10, Ref.13 and Ref.18), variations in OLR1 modify the risk of AD, while according to other (Ref.15 and Ref.16), they do not"	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/04	2017/08/10	rogid:RdjeN/PNRUz4gOdl9d4llyFoUSY9606	rogid:RdjeN/PNRUz4gOdl9d4llyFoUSY9606	rigid:ja48ibXyzEFFVvDdkc7/dqVABmU	false	sufficient binding region:129-273	sufficient binding region:129-273	-	0	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:P78380	uniprotkb:P78380	intact:EBI-7151999|ensembl:ENSP00000309124|uniprotkb:G3V1I4|uniprotkb:Q2PP00|intact:MINT-1343572|uniprotkb:Q7Z484|uniprotkb:B4DI48|uniprotkb:A8K7V9	intact:EBI-7151999|ensembl:ENSP00000309124|uniprotkb:G3V1I4|uniprotkb:Q2PP00|intact:MINT-1343572|uniprotkb:Q7Z484|uniprotkb:B4DI48|uniprotkb:A8K7V9	psi-mi:olr1_human(display_long)|uniprotkb:OLR1(gene name)|psi-mi:OLR1(display_short)|uniprotkb:LOX1(gene name synonym)|uniprotkb:Lectin-type oxidized LDL receptor 1(gene name synonym)|uniprotkb:Lectin-like oxidized LDL receptor 1(gene name synonym)|uniprotkb:CLEC8A(gene name synonym)|uniprotkb:C-type lectin domain family 8 member A(gene name synonym)	psi-mi:olr1_human(display_long)|uniprotkb:OLR1(gene name)|psi-mi:OLR1(display_short)|uniprotkb:LOX1(gene name synonym)|uniprotkb:Lectin-type oxidized LDL receptor 1(gene name synonym)|uniprotkb:Lectin-like oxidized LDL receptor 1(gene name synonym)|uniprotkb:CLEC8A(gene name synonym)|uniprotkb:C-type lectin domain family 8 member A(gene name synonym)	psi-mi:"MI:0028"(cosedimentation in solution)	Ohki et al. (2005)	pubmed:15939022|doi:10.1016/j.str.2005.03.016|imex:IM-14202	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15553186|imex:IM-14202-2|dip:DIP-102914E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000173391(gene)|ensembl:ENST00000309539(transcript)|go:"GO:0002376"(immune system process)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0008015"(blood circulation)|go:"GO:0008219"(cell death)|go:"GO:0016020"(membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0045121"(membrane raft)|go:"GO:0070821"(tertiary granule membrane)|interpro:IPR001304(C-type lectin)|interpro:IPR013600(Ly49-like N-terminal)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR033992|mint:P78380|rcsb pdb:1YPO|rcsb pdb:1YPQ|rcsb pdb:1YPU|rcsb pdb:1YXJ|rcsb pdb:1YXK|rcsb pdb:3VLG|rcsb pdb:6TL7|rcsb pdb:6TL9|rcsb pdb:6TLA|reactome:R-HSA-202733|reactome:R-HSA-6798695|refseq:NP_001166104.1|refseq:NP_002534.1|refseq:NP_001166103.1|dip:DIP-42040N	ensembl:ENSG00000173391(gene)|ensembl:ENST00000309539(transcript)|go:"GO:0002376"(immune system process)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0008015"(blood circulation)|go:"GO:0008219"(cell death)|go:"GO:0016020"(membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0045121"(membrane raft)|go:"GO:0070821"(tertiary granule membrane)|interpro:IPR001304(C-type lectin)|interpro:IPR013600(Ly49-like N-terminal)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR033992|mint:P78380|rcsb pdb:1YPO|rcsb pdb:1YPQ|rcsb pdb:1YPU|rcsb pdb:1YXJ|rcsb pdb:1YXK|rcsb pdb:3VLG|rcsb pdb:6TL7|rcsb pdb:6TL9|rcsb pdb:6TLA|reactome:R-HSA-202733|reactome:R-HSA-6798695|refseq:NP_001166104.1|refseq:NP_002534.1|refseq:NP_001166103.1|dip:DIP-42040N	psi-mi:"MI:0465"(dip)	function:"Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria"|comment:mint|function:"Defects in OLR1 may be a cause of susceptibility to myocardial infarction [MIM:608557]"|function:"Defects in OLR1 may be associated with susceptibility to Alzheimer disease (AD) [MIM:104300]. Involvement in AD is however unclear: according to some authors (Ref.10, Ref.13 and Ref.18), variations in OLR1 modify the risk of AD, while according to other (Ref.15 and Ref.16), they do not"	function:"Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria"|comment:mint|function:"Defects in OLR1 may be a cause of susceptibility to myocardial infarction [MIM:608557]"|function:"Defects in OLR1 may be associated with susceptibility to Alzheimer disease (AD) [MIM:104300]. Involvement in AD is however unclear: according to some authors (Ref.10, Ref.13 and Ref.18), variations in OLR1 modify the risk of AD, while according to other (Ref.15 and Ref.16), they do not"	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/04	2017/08/10	rogid:RdjeN/PNRUz4gOdl9d4llyFoUSY9606	rogid:RdjeN/PNRUz4gOdl9d4llyFoUSY9606	rigid:ja48ibXyzEFFVvDdkc7/dqVABmU	false	sufficient binding region:129-273	sufficient binding region:129-273	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P78380	uniprotkb:P78380	intact:EBI-7151999|ensembl:ENSP00000309124|uniprotkb:G3V1I4|uniprotkb:Q2PP00|intact:MINT-1343572|uniprotkb:Q7Z484|uniprotkb:B4DI48|uniprotkb:A8K7V9	intact:EBI-7151999|ensembl:ENSP00000309124|uniprotkb:G3V1I4|uniprotkb:Q2PP00|intact:MINT-1343572|uniprotkb:Q7Z484|uniprotkb:B4DI48|uniprotkb:A8K7V9	psi-mi:olr1_human(display_long)|uniprotkb:OLR1(gene name)|psi-mi:OLR1(display_short)|uniprotkb:LOX1(gene name synonym)|uniprotkb:Lectin-type oxidized LDL receptor 1(gene name synonym)|uniprotkb:Lectin-like oxidized LDL receptor 1(gene name synonym)|uniprotkb:CLEC8A(gene name synonym)|uniprotkb:C-type lectin domain family 8 member A(gene name synonym)	psi-mi:olr1_human(display_long)|uniprotkb:OLR1(gene name)|psi-mi:OLR1(display_short)|uniprotkb:LOX1(gene name synonym)|uniprotkb:Lectin-type oxidized LDL receptor 1(gene name synonym)|uniprotkb:Lectin-like oxidized LDL receptor 1(gene name synonym)|uniprotkb:CLEC8A(gene name synonym)|uniprotkb:C-type lectin domain family 8 member A(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Ohki et al. (2005)	pubmed:15939022|doi:10.1016/j.str.2005.03.016|imex:IM-14202	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15553206|imex:IM-14202-3|dip:DIP-102914E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000173391(gene)|ensembl:ENST00000309539(transcript)|go:"GO:0002376"(immune system process)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0008015"(blood circulation)|go:"GO:0008219"(cell death)|go:"GO:0016020"(membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0045121"(membrane raft)|go:"GO:0070821"(tertiary granule membrane)|interpro:IPR001304(C-type lectin)|interpro:IPR013600(Ly49-like N-terminal)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR033992|mint:P78380|rcsb pdb:1YPO|rcsb pdb:1YPQ|rcsb pdb:1YPU|rcsb pdb:1YXJ|rcsb pdb:1YXK|rcsb pdb:3VLG|rcsb pdb:6TL7|rcsb pdb:6TL9|rcsb pdb:6TLA|reactome:R-HSA-202733|reactome:R-HSA-6798695|refseq:NP_001166104.1|refseq:NP_002534.1|refseq:NP_001166103.1|dip:DIP-42040N	ensembl:ENSG00000173391(gene)|ensembl:ENST00000309539(transcript)|go:"GO:0002376"(immune system process)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0008015"(blood circulation)|go:"GO:0008219"(cell death)|go:"GO:0016020"(membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0045121"(membrane raft)|go:"GO:0070821"(tertiary granule membrane)|interpro:IPR001304(C-type lectin)|interpro:IPR013600(Ly49-like N-terminal)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR033992|mint:P78380|rcsb pdb:1YPO|rcsb pdb:1YPQ|rcsb pdb:1YPU|rcsb pdb:1YXJ|rcsb pdb:1YXK|rcsb pdb:3VLG|rcsb pdb:6TL7|rcsb pdb:6TL9|rcsb pdb:6TLA|reactome:R-HSA-202733|reactome:R-HSA-6798695|refseq:NP_001166104.1|refseq:NP_002534.1|refseq:NP_001166103.1|dip:DIP-42040N	psi-mi:"MI:0465"(dip)	function:"Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria"|comment:mint|function:"Defects in OLR1 may be a cause of susceptibility to myocardial infarction [MIM:608557]"|function:"Defects in OLR1 may be associated with susceptibility to Alzheimer disease (AD) [MIM:104300]. Involvement in AD is however unclear: according to some authors (Ref.10, Ref.13 and Ref.18), variations in OLR1 modify the risk of AD, while according to other (Ref.15 and Ref.16), they do not"	function:"Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria"|comment:mint|function:"Defects in OLR1 may be a cause of susceptibility to myocardial infarction [MIM:608557]"|function:"Defects in OLR1 may be associated with susceptibility to Alzheimer disease (AD) [MIM:104300]. Involvement in AD is however unclear: according to some authors (Ref.10, Ref.13 and Ref.18), variations in OLR1 modify the risk of AD, while according to other (Ref.15 and Ref.16), they do not"	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/04	2017/08/10	rogid:RdjeN/PNRUz4gOdl9d4llyFoUSY9606	rogid:RdjeN/PNRUz4gOdl9d4llyFoUSY9606	rigid:ja48ibXyzEFFVvDdkc7/dqVABmU	false	binding-associated region:143-273	binding-associated region:143-273	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)