#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q02685 uniprotkb:P35187 intact:EBI-38690|uniprotkb:D6W3Y8|ensemblfungi:YPL024W intact:EBI-17059|uniprotkb:D6W014|ensemblfungi:YMR190C psi-mi:rmi1_yeast(display_long)|uniprotkb:RMI1(gene name)|psi-mi:RMI1(display_short)|uniprotkb:NCE4(gene name synonym)|uniprotkb:YPL024W(locus name) psi-mi:sgs1_yeast(display_long)|uniprotkb:SGS1(gene name)|psi-mi:SGS1(display_short)|uniprotkb:TPS1(gene name synonym)|uniprotkb:YMR190C(locus name)|uniprotkb:YM9646.02C(orf name)|uniprotkb:Helicase TPS1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mullen et al. (2005) imex:IM-25670|pubmed:15899853 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-13946266|imex:IM-25670-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_015301.1|sgd:S000005945|mint:Q02685|dip:DIP-4039N|ensemblfungi:YPL024W(gene)|ensemblfungi:YPL024W_mRNA(transcript)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006265"(DNA topological change)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0031422"(RecQ family helicase-topoisomerase III complex)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043596"(nuclear replication fork)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR013894(Region of unknown function DUF1767) go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006265"(DNA topological change)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0007534"(gene conversion at mating-type locus)|go:"GO:0009378"(four-way junction helicase activity)|go:"GO:0010520"(regulation of reciprocal meiotic recombination)|go:"GO:0010947"(negative regulation of meiotic joint molecule formation)|go:"GO:0031422"(RecQ family helicase-topoisomerase III complex)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0031860"(telomeric 3' overhang formation)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0044818"(mitotic G2/M transition checkpoint)|go:"GO:0045132"(meiotic chromosome segregation)|go:"GO:0051276"(chromosome organization)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:0005634"(nucleus)|interpro:IPR002121(Helicase and RNase D C-terminal, HRDC)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|interpro:IPR004589(DNA helicase, ATP-dependent, RecQ type)|interpro:IPR010997(HRDC-like)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR018982|interpro:IPR022758|interpro:IPR027417|interpro:IPR032284|interpro:IPR036388|rcsb pdb:1D8B|interpro:IPR001650(DNA/RNA helicase, C-terminal)|refseq:NP_013915.1|sgd:S000004802|ensemblfungi:YMR190C(gene)|ensemblfungi:YMR190C_mRNA(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0005524"(ATP binding)|dip:DIP-2911N|mint:P35187 - crc64:65EF152F50BF0084 crc64:0DC320B41756A3C3 figure legend:Fig. 4A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2017/03/08 2017/03/08 rogid:6vrkb5T1C2mV3fInk0bzsKuIudQ559292 rogid:kSX/9U/Qjnhm6doWBmFCKOC8dJo559292 rigid:3RV2wkFtDlY52xcfQyX8JWlsbVc false ha tag:c-c flag tag:c-c - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q02685 uniprotkb:P13099 intact:EBI-38690|uniprotkb:D6W3Y8|ensemblfungi:YPL024W intact:EBI-19365|uniprotkb:D6VYN4|ensemblfungi:YLR234W psi-mi:rmi1_yeast(display_long)|uniprotkb:RMI1(gene name)|psi-mi:RMI1(display_short)|uniprotkb:NCE4(gene name synonym)|uniprotkb:YPL024W(locus name) psi-mi:top3_yeast(display_long)|uniprotkb:TOP3(gene name)|psi-mi:TOP3(display_short)|uniprotkb:EDR1(gene name synonym)|uniprotkb:YLR234W(locus name)|uniprotkb:L8083.3(orf name)|uniprotkb:DNA topoisomerase III(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mullen et al. (2005) imex:IM-25670|pubmed:15899853 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-13946266|imex:IM-25670-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_015301.1|sgd:S000005945|mint:Q02685|dip:DIP-4039N|ensemblfungi:YPL024W(gene)|ensemblfungi:YPL024W_mRNA(transcript)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006265"(DNA topological change)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0031422"(RecQ family helicase-topoisomerase III complex)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043596"(nuclear replication fork)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR013894(Region of unknown function DUF1767) refseq:NP_013335.1|sgd:S000004224|go:"GO:0003917"("DNA topoisomerase type I (single strand cut, ATP-independent) activity")|go:"GO:0005634"(nucleus)|go:"GO:0006265"(DNA topological change)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0031422"(RecQ family helicase-topoisomerase III complex)|interpro:IPR000380(DNA topoisomerase, type IA, core)|interpro:IPR003601(DNA topoisomerase, type IA, domain 2)|interpro:IPR003602(DNA topoisomerase, type IA, DNA-binding)|interpro:IPR006171(TOPRIM)|interpro:IPR013497(DNA topoisomerase, type IA, central)|interpro:IPR013824(DNA topoisomerase, type IA, central region, subdomain 1)|interpro:IPR013825(DNA topoisomerase, type IA, central region, subdomain 2)|interpro:IPR013826(DNA topoisomerase, type IA, central region, subdomain 3)|interpro:IPR023405|interpro:IPR023406|interpro:IPR034144|go:"GO:0003916"(DNA topoisomerase activity)|ensemblfungi:YLR234W(gene)|ensemblfungi:YLR234W_mRNA(transcript)|go:"GO:0000018"(regulation of DNA recombination)|go:"GO:0003677"(DNA binding)|dip:DIP-2912N|mint:P13099 - crc64:65EF152F50BF0084 crc64:51DF78936A88B4F4 figure legend:Fig. 4A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2017/03/08 2017/03/08 rogid:6vrkb5T1C2mV3fInk0bzsKuIudQ559292 rogid:7guk14sg6ZTut5+2ip8U/NkS9M0559292 rigid:3RV2wkFtDlY52xcfQyX8JWlsbVc false ha tag:c-c v5 tag:c-c - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P35187 uniprotkb:Q02685 intact:EBI-17059|uniprotkb:D6W014|ensemblfungi:YMR190C intact:EBI-38690|uniprotkb:D6W3Y8|ensemblfungi:YPL024W psi-mi:sgs1_yeast(display_long)|uniprotkb:SGS1(gene name)|psi-mi:SGS1(display_short)|uniprotkb:TPS1(gene name synonym)|uniprotkb:YMR190C(locus name)|uniprotkb:YM9646.02C(orf name)|uniprotkb:Helicase TPS1(gene name synonym) psi-mi:rmi1_yeast(display_long)|uniprotkb:RMI1(gene name)|psi-mi:RMI1(display_short)|uniprotkb:NCE4(gene name synonym)|uniprotkb:YPL024W(locus name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mullen et al. (2005) imex:IM-25670|pubmed:15899853 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-13946278|imex:IM-25670-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006265"(DNA topological change)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0007534"(gene conversion at mating-type locus)|go:"GO:0009378"(four-way junction helicase activity)|go:"GO:0010520"(regulation of reciprocal meiotic recombination)|go:"GO:0010947"(negative regulation of meiotic joint molecule formation)|go:"GO:0031422"(RecQ family helicase-topoisomerase III complex)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0031860"(telomeric 3' overhang formation)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0044818"(mitotic G2/M transition checkpoint)|go:"GO:0045132"(meiotic chromosome segregation)|go:"GO:0051276"(chromosome organization)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:0005634"(nucleus)|interpro:IPR002121(Helicase and RNase D C-terminal, HRDC)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|interpro:IPR004589(DNA helicase, ATP-dependent, RecQ type)|interpro:IPR010997(HRDC-like)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR018982|interpro:IPR022758|interpro:IPR027417|interpro:IPR032284|interpro:IPR036388|rcsb pdb:1D8B|interpro:IPR001650(DNA/RNA helicase, C-terminal)|refseq:NP_013915.1|sgd:S000004802|ensemblfungi:YMR190C(gene)|ensemblfungi:YMR190C_mRNA(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0005524"(ATP binding)|dip:DIP-2911N|mint:P35187 refseq:NP_015301.1|sgd:S000005945|mint:Q02685|dip:DIP-4039N|ensemblfungi:YPL024W(gene)|ensemblfungi:YPL024W_mRNA(transcript)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006265"(DNA topological change)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0031422"(RecQ family helicase-topoisomerase III complex)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043596"(nuclear replication fork)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR013894(Region of unknown function DUF1767) - crc64:0DC320B41756A3C3 crc64:65EF152F50BF0084 figure legend:Fig. 4A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2017/03/08 2017/03/08 rogid:kSX/9U/Qjnhm6doWBmFCKOC8dJo559292 rogid:6vrkb5T1C2mV3fInk0bzsKuIudQ559292 rigid:3RV2wkFtDlY52xcfQyX8JWlsbVc false flag tag:c-c ha tag:c-c - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P35187 uniprotkb:P13099 intact:EBI-17059|uniprotkb:D6W014|ensemblfungi:YMR190C intact:EBI-19365|uniprotkb:D6VYN4|ensemblfungi:YLR234W psi-mi:sgs1_yeast(display_long)|uniprotkb:SGS1(gene name)|psi-mi:SGS1(display_short)|uniprotkb:TPS1(gene name synonym)|uniprotkb:YMR190C(locus name)|uniprotkb:YM9646.02C(orf name)|uniprotkb:Helicase TPS1(gene name synonym) psi-mi:top3_yeast(display_long)|uniprotkb:TOP3(gene name)|psi-mi:TOP3(display_short)|uniprotkb:EDR1(gene name synonym)|uniprotkb:YLR234W(locus name)|uniprotkb:L8083.3(orf name)|uniprotkb:DNA topoisomerase III(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mullen et al. (2005) imex:IM-25670|pubmed:15899853 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-13946278|imex:IM-25670-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006265"(DNA topological change)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0007534"(gene conversion at mating-type locus)|go:"GO:0009378"(four-way junction helicase activity)|go:"GO:0010520"(regulation of reciprocal meiotic recombination)|go:"GO:0010947"(negative regulation of meiotic joint molecule formation)|go:"GO:0031422"(RecQ family helicase-topoisomerase III complex)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0031860"(telomeric 3' overhang formation)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0044818"(mitotic G2/M transition checkpoint)|go:"GO:0045132"(meiotic chromosome segregation)|go:"GO:0051276"(chromosome organization)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:0005634"(nucleus)|interpro:IPR002121(Helicase and RNase D C-terminal, HRDC)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|interpro:IPR004589(DNA helicase, ATP-dependent, RecQ type)|interpro:IPR010997(HRDC-like)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR018982|interpro:IPR022758|interpro:IPR027417|interpro:IPR032284|interpro:IPR036388|rcsb pdb:1D8B|interpro:IPR001650(DNA/RNA helicase, C-terminal)|refseq:NP_013915.1|sgd:S000004802|ensemblfungi:YMR190C(gene)|ensemblfungi:YMR190C_mRNA(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0005524"(ATP binding)|dip:DIP-2911N|mint:P35187 refseq:NP_013335.1|sgd:S000004224|go:"GO:0003917"("DNA topoisomerase type I (single strand cut, ATP-independent) activity")|go:"GO:0005634"(nucleus)|go:"GO:0006265"(DNA topological change)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0031422"(RecQ family helicase-topoisomerase III complex)|interpro:IPR000380(DNA topoisomerase, type IA, core)|interpro:IPR003601(DNA topoisomerase, type IA, domain 2)|interpro:IPR003602(DNA topoisomerase, type IA, DNA-binding)|interpro:IPR006171(TOPRIM)|interpro:IPR013497(DNA topoisomerase, type IA, central)|interpro:IPR013824(DNA topoisomerase, type IA, central region, subdomain 1)|interpro:IPR013825(DNA topoisomerase, type IA, central region, subdomain 2)|interpro:IPR013826(DNA topoisomerase, type IA, central region, subdomain 3)|interpro:IPR023405|interpro:IPR023406|interpro:IPR034144|go:"GO:0003916"(DNA topoisomerase activity)|ensemblfungi:YLR234W(gene)|ensemblfungi:YLR234W_mRNA(transcript)|go:"GO:0000018"(regulation of DNA recombination)|go:"GO:0003677"(DNA binding)|dip:DIP-2912N|mint:P13099 - crc64:0DC320B41756A3C3 crc64:51DF78936A88B4F4 figure legend:Fig. 4A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2017/03/08 2017/03/08 rogid:kSX/9U/Qjnhm6doWBmFCKOC8dJo559292 rogid:7guk14sg6ZTut5+2ip8U/NkS9M0559292 rigid:3RV2wkFtDlY52xcfQyX8JWlsbVc false flag tag:c-c v5 tag:c-c - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P13099 uniprotkb:Q02685 intact:EBI-19365|uniprotkb:D6VYN4|ensemblfungi:YLR234W intact:EBI-38690|uniprotkb:D6W3Y8|ensemblfungi:YPL024W psi-mi:top3_yeast(display_long)|uniprotkb:TOP3(gene name)|psi-mi:TOP3(display_short)|uniprotkb:EDR1(gene name synonym)|uniprotkb:YLR234W(locus name)|uniprotkb:L8083.3(orf name)|uniprotkb:DNA topoisomerase III(gene name synonym) psi-mi:rmi1_yeast(display_long)|uniprotkb:RMI1(gene name)|psi-mi:RMI1(display_short)|uniprotkb:NCE4(gene name synonym)|uniprotkb:YPL024W(locus name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mullen et al. (2005) imex:IM-25670|pubmed:15899853 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-13946289|imex:IM-25670-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_013335.1|sgd:S000004224|go:"GO:0003917"("DNA topoisomerase type I (single strand cut, ATP-independent) activity")|go:"GO:0005634"(nucleus)|go:"GO:0006265"(DNA topological change)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0031422"(RecQ family helicase-topoisomerase III complex)|interpro:IPR000380(DNA topoisomerase, type IA, core)|interpro:IPR003601(DNA topoisomerase, type IA, domain 2)|interpro:IPR003602(DNA topoisomerase, type IA, DNA-binding)|interpro:IPR006171(TOPRIM)|interpro:IPR013497(DNA topoisomerase, type IA, central)|interpro:IPR013824(DNA topoisomerase, type IA, central region, subdomain 1)|interpro:IPR013825(DNA topoisomerase, type IA, central region, subdomain 2)|interpro:IPR013826(DNA topoisomerase, type IA, central region, subdomain 3)|interpro:IPR023405|interpro:IPR023406|interpro:IPR034144|go:"GO:0003916"(DNA topoisomerase activity)|ensemblfungi:YLR234W(gene)|ensemblfungi:YLR234W_mRNA(transcript)|go:"GO:0000018"(regulation of DNA recombination)|go:"GO:0003677"(DNA binding)|dip:DIP-2912N|mint:P13099 refseq:NP_015301.1|sgd:S000005945|mint:Q02685|dip:DIP-4039N|ensemblfungi:YPL024W(gene)|ensemblfungi:YPL024W_mRNA(transcript)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006265"(DNA topological change)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0031422"(RecQ family helicase-topoisomerase III complex)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043596"(nuclear replication fork)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR013894(Region of unknown function DUF1767) - crc64:51DF78936A88B4F4 crc64:65EF152F50BF0084 figure legend:Fig. 4A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2017/03/08 2017/03/08 rogid:7guk14sg6ZTut5+2ip8U/NkS9M0559292 rogid:6vrkb5T1C2mV3fInk0bzsKuIudQ559292 rigid:3RV2wkFtDlY52xcfQyX8JWlsbVc false v5 tag:c-c ha tag:c-c - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P13099 uniprotkb:P35187 intact:EBI-19365|uniprotkb:D6VYN4|ensemblfungi:YLR234W intact:EBI-17059|uniprotkb:D6W014|ensemblfungi:YMR190C psi-mi:top3_yeast(display_long)|uniprotkb:TOP3(gene name)|psi-mi:TOP3(display_short)|uniprotkb:EDR1(gene name synonym)|uniprotkb:YLR234W(locus name)|uniprotkb:L8083.3(orf name)|uniprotkb:DNA topoisomerase III(gene name synonym) psi-mi:sgs1_yeast(display_long)|uniprotkb:SGS1(gene name)|psi-mi:SGS1(display_short)|uniprotkb:TPS1(gene name synonym)|uniprotkb:YMR190C(locus name)|uniprotkb:YM9646.02C(orf name)|uniprotkb:Helicase TPS1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mullen et al. (2005) imex:IM-25670|pubmed:15899853 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-13946289|imex:IM-25670-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_013335.1|sgd:S000004224|go:"GO:0003917"("DNA topoisomerase type I (single strand cut, ATP-independent) activity")|go:"GO:0005634"(nucleus)|go:"GO:0006265"(DNA topological change)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0031422"(RecQ family helicase-topoisomerase III complex)|interpro:IPR000380(DNA topoisomerase, type IA, core)|interpro:IPR003601(DNA topoisomerase, type IA, domain 2)|interpro:IPR003602(DNA topoisomerase, type IA, DNA-binding)|interpro:IPR006171(TOPRIM)|interpro:IPR013497(DNA topoisomerase, type IA, central)|interpro:IPR013824(DNA topoisomerase, type IA, central region, subdomain 1)|interpro:IPR013825(DNA topoisomerase, type IA, central region, subdomain 2)|interpro:IPR013826(DNA topoisomerase, type IA, central region, subdomain 3)|interpro:IPR023405|interpro:IPR023406|interpro:IPR034144|go:"GO:0003916"(DNA topoisomerase activity)|ensemblfungi:YLR234W(gene)|ensemblfungi:YLR234W_mRNA(transcript)|go:"GO:0000018"(regulation of DNA recombination)|go:"GO:0003677"(DNA binding)|dip:DIP-2912N|mint:P13099 go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006265"(DNA topological change)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0007534"(gene conversion at mating-type locus)|go:"GO:0009378"(four-way junction helicase activity)|go:"GO:0010520"(regulation of reciprocal meiotic recombination)|go:"GO:0010947"(negative regulation of meiotic joint molecule formation)|go:"GO:0031422"(RecQ family helicase-topoisomerase III complex)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0031860"(telomeric 3' overhang formation)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0044818"(mitotic G2/M transition checkpoint)|go:"GO:0045132"(meiotic chromosome segregation)|go:"GO:0051276"(chromosome organization)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:0005634"(nucleus)|interpro:IPR002121(Helicase and RNase D C-terminal, HRDC)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|interpro:IPR004589(DNA helicase, ATP-dependent, RecQ type)|interpro:IPR010997(HRDC-like)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR018982|interpro:IPR022758|interpro:IPR027417|interpro:IPR032284|interpro:IPR036388|rcsb pdb:1D8B|interpro:IPR001650(DNA/RNA helicase, C-terminal)|refseq:NP_013915.1|sgd:S000004802|ensemblfungi:YMR190C(gene)|ensemblfungi:YMR190C_mRNA(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0005524"(ATP binding)|dip:DIP-2911N|mint:P35187 - crc64:51DF78936A88B4F4 crc64:0DC320B41756A3C3 figure legend:Fig. 4A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2017/03/08 2017/03/08 rogid:7guk14sg6ZTut5+2ip8U/NkS9M0559292 rogid:kSX/9U/Qjnhm6doWBmFCKOC8dJo559292 rigid:3RV2wkFtDlY52xcfQyX8JWlsbVc false v5 tag:c-c flag tag:c-c - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q02685 uniprotkb:P13099 intact:EBI-38690|uniprotkb:D6W3Y8|ensemblfungi:YPL024W intact:EBI-19365|uniprotkb:D6VYN4|ensemblfungi:YLR234W psi-mi:rmi1_yeast(display_long)|uniprotkb:RMI1(gene name)|psi-mi:RMI1(display_short)|uniprotkb:NCE4(gene name synonym)|uniprotkb:YPL024W(locus name) psi-mi:top3_yeast(display_long)|uniprotkb:TOP3(gene name)|psi-mi:TOP3(display_short)|uniprotkb:EDR1(gene name synonym)|uniprotkb:YLR234W(locus name)|uniprotkb:L8083.3(orf name)|uniprotkb:DNA topoisomerase III(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mullen et al. (2005) imex:IM-25670|pubmed:15899853 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13946300|imex:IM-25670-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_015301.1|sgd:S000005945|mint:Q02685|dip:DIP-4039N|ensemblfungi:YPL024W(gene)|ensemblfungi:YPL024W_mRNA(transcript)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006265"(DNA topological change)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0031422"(RecQ family helicase-topoisomerase III complex)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043596"(nuclear replication fork)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR013894(Region of unknown function DUF1767) refseq:NP_013335.1|sgd:S000004224|go:"GO:0003917"("DNA topoisomerase type I (single strand cut, ATP-independent) activity")|go:"GO:0005634"(nucleus)|go:"GO:0006265"(DNA topological change)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0031422"(RecQ family helicase-topoisomerase III complex)|interpro:IPR000380(DNA topoisomerase, type IA, core)|interpro:IPR003601(DNA topoisomerase, type IA, domain 2)|interpro:IPR003602(DNA topoisomerase, type IA, DNA-binding)|interpro:IPR006171(TOPRIM)|interpro:IPR013497(DNA topoisomerase, type IA, central)|interpro:IPR013824(DNA topoisomerase, type IA, central region, subdomain 1)|interpro:IPR013825(DNA topoisomerase, type IA, central region, subdomain 2)|interpro:IPR013826(DNA topoisomerase, type IA, central region, subdomain 3)|interpro:IPR023405|interpro:IPR023406|interpro:IPR034144|go:"GO:0003916"(DNA topoisomerase activity)|ensemblfungi:YLR234W(gene)|ensemblfungi:YLR234W_mRNA(transcript)|go:"GO:0000018"(regulation of DNA recombination)|go:"GO:0003677"(DNA binding)|dip:DIP-2912N|mint:P13099 - crc64:65EF152F50BF0084 crc64:51DF78936A88B4F4 figure legend:Fig. 4A|comment:Interaction observed in SGS1-/-|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2017/03/08 2017/03/08 rogid:6vrkb5T1C2mV3fInk0bzsKuIudQ559292 rogid:7guk14sg6ZTut5+2ip8U/NkS9M0559292 rigid:AOqUNTYjZkSX8ZpDxfUXp0axqNM false ha tag:c-c v5 tag:c-c - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q02685 uniprotkb:P13099 intact:EBI-38690|uniprotkb:D6W3Y8|ensemblfungi:YPL024W intact:EBI-19365|uniprotkb:D6VYN4|ensemblfungi:YLR234W psi-mi:rmi1_yeast(display_long)|uniprotkb:RMI1(gene name)|psi-mi:RMI1(display_short)|uniprotkb:NCE4(gene name synonym)|uniprotkb:YPL024W(locus name) psi-mi:top3_yeast(display_long)|uniprotkb:TOP3(gene name)|psi-mi:TOP3(display_short)|uniprotkb:EDR1(gene name synonym)|uniprotkb:YLR234W(locus name)|uniprotkb:L8083.3(orf name)|uniprotkb:DNA topoisomerase III(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mullen et al. (2005) imex:IM-25670|pubmed:15899853 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13946319|imex:IM-25670-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_015301.1|sgd:S000005945|mint:Q02685|dip:DIP-4039N|ensemblfungi:YPL024W(gene)|ensemblfungi:YPL024W_mRNA(transcript)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006265"(DNA topological change)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0031422"(RecQ family helicase-topoisomerase III complex)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043596"(nuclear replication fork)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR013894(Region of unknown function DUF1767) refseq:NP_013335.1|sgd:S000004224|go:"GO:0003917"("DNA topoisomerase type I (single strand cut, ATP-independent) activity")|go:"GO:0005634"(nucleus)|go:"GO:0006265"(DNA topological change)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0031422"(RecQ family helicase-topoisomerase III complex)|interpro:IPR000380(DNA topoisomerase, type IA, core)|interpro:IPR003601(DNA topoisomerase, type IA, domain 2)|interpro:IPR003602(DNA topoisomerase, type IA, DNA-binding)|interpro:IPR006171(TOPRIM)|interpro:IPR013497(DNA topoisomerase, type IA, central)|interpro:IPR013824(DNA topoisomerase, type IA, central region, subdomain 1)|interpro:IPR013825(DNA topoisomerase, type IA, central region, subdomain 2)|interpro:IPR013826(DNA topoisomerase, type IA, central region, subdomain 3)|interpro:IPR023405|interpro:IPR023406|interpro:IPR034144|go:"GO:0003916"(DNA topoisomerase activity)|ensemblfungi:YLR234W(gene)|ensemblfungi:YLR234W_mRNA(transcript)|go:"GO:0000018"(regulation of DNA recombination)|go:"GO:0003677"(DNA binding)|dip:DIP-2912N|mint:P13099 - crc64:65EF152F50BF0084 crc64:51DF78936A88B4F4 figure legend:Fig. 4A|comment:Interaction observed in SGS1-/-|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2017/03/08 2017/03/08 rogid:6vrkb5T1C2mV3fInk0bzsKuIudQ559292 rogid:7guk14sg6ZTut5+2ip8U/NkS9M0559292 rigid:AOqUNTYjZkSX8ZpDxfUXp0axqNM false ha tag:c-c v5 tag:c-c - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q02685 uniprotkb:P35187 intact:EBI-38690|uniprotkb:D6W3Y8|ensemblfungi:YPL024W intact:EBI-17059|uniprotkb:D6W014|ensemblfungi:YMR190C psi-mi:rmi1_yeast(display_long)|uniprotkb:RMI1(gene name)|psi-mi:RMI1(display_short)|uniprotkb:NCE4(gene name synonym)|uniprotkb:YPL024W(locus name) psi-mi:sgs1_yeast(display_long)|uniprotkb:SGS1(gene name)|psi-mi:SGS1(display_short)|uniprotkb:TPS1(gene name synonym)|uniprotkb:YMR190C(locus name)|uniprotkb:YM9646.02C(orf name)|uniprotkb:Helicase TPS1(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Mullen et al. (2005) imex:IM-25670|pubmed:15899853 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13946338|imex:IM-25670-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_015301.1|sgd:S000005945|mint:Q02685|dip:DIP-4039N|ensemblfungi:YPL024W(gene)|ensemblfungi:YPL024W_mRNA(transcript)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006265"(DNA topological change)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0031422"(RecQ family helicase-topoisomerase III complex)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043596"(nuclear replication fork)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR013894(Region of unknown function DUF1767) go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006265"(DNA topological change)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0007534"(gene conversion at mating-type locus)|go:"GO:0009378"(four-way junction helicase activity)|go:"GO:0010520"(regulation of reciprocal meiotic recombination)|go:"GO:0010947"(negative regulation of meiotic joint molecule formation)|go:"GO:0031422"(RecQ family helicase-topoisomerase III complex)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0031860"(telomeric 3' overhang formation)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0044818"(mitotic G2/M transition checkpoint)|go:"GO:0045132"(meiotic chromosome segregation)|go:"GO:0051276"(chromosome organization)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:0005634"(nucleus)|interpro:IPR002121(Helicase and RNase D C-terminal, HRDC)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|interpro:IPR004589(DNA helicase, ATP-dependent, RecQ type)|interpro:IPR010997(HRDC-like)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR018982|interpro:IPR022758|interpro:IPR027417|interpro:IPR032284|interpro:IPR036388|rcsb pdb:1D8B|interpro:IPR001650(DNA/RNA helicase, C-terminal)|refseq:NP_013915.1|sgd:S000004802|ensemblfungi:YMR190C(gene)|ensemblfungi:YMR190C_mRNA(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0005524"(ATP binding)|dip:DIP-2911N|mint:P35187 - crc64:65EF152F50BF0084 crc64:0DC320B41756A3C3 figure legend:Fig. 4B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2017/03/08 2017/03/08 rogid:6vrkb5T1C2mV3fInk0bzsKuIudQ559292 rogid:kSX/9U/Qjnhm6doWBmFCKOC8dJo559292 rigid:3RV2wkFtDlY52xcfQyX8JWlsbVc false ha tag:c-c flag tag:c-c - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q02685 uniprotkb:P13099 intact:EBI-38690|uniprotkb:D6W3Y8|ensemblfungi:YPL024W intact:EBI-19365|uniprotkb:D6VYN4|ensemblfungi:YLR234W psi-mi:rmi1_yeast(display_long)|uniprotkb:RMI1(gene name)|psi-mi:RMI1(display_short)|uniprotkb:NCE4(gene name synonym)|uniprotkb:YPL024W(locus name) psi-mi:top3_yeast(display_long)|uniprotkb:TOP3(gene name)|psi-mi:TOP3(display_short)|uniprotkb:EDR1(gene name synonym)|uniprotkb:YLR234W(locus name)|uniprotkb:L8083.3(orf name)|uniprotkb:DNA topoisomerase III(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Mullen et al. (2005) imex:IM-25670|pubmed:15899853 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13946338|imex:IM-25670-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_015301.1|sgd:S000005945|mint:Q02685|dip:DIP-4039N|ensemblfungi:YPL024W(gene)|ensemblfungi:YPL024W_mRNA(transcript)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006265"(DNA topological change)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0031422"(RecQ family helicase-topoisomerase III complex)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043596"(nuclear replication fork)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR013894(Region of unknown function DUF1767) refseq:NP_013335.1|sgd:S000004224|go:"GO:0003917"("DNA topoisomerase type I (single strand cut, ATP-independent) activity")|go:"GO:0005634"(nucleus)|go:"GO:0006265"(DNA topological change)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0031422"(RecQ family helicase-topoisomerase III complex)|interpro:IPR000380(DNA topoisomerase, type IA, core)|interpro:IPR003601(DNA topoisomerase, type IA, domain 2)|interpro:IPR003602(DNA topoisomerase, type IA, DNA-binding)|interpro:IPR006171(TOPRIM)|interpro:IPR013497(DNA topoisomerase, type IA, central)|interpro:IPR013824(DNA topoisomerase, type IA, central region, subdomain 1)|interpro:IPR013825(DNA topoisomerase, type IA, central region, subdomain 2)|interpro:IPR013826(DNA topoisomerase, type IA, central region, subdomain 3)|interpro:IPR023405|interpro:IPR023406|interpro:IPR034144|go:"GO:0003916"(DNA topoisomerase activity)|ensemblfungi:YLR234W(gene)|ensemblfungi:YLR234W_mRNA(transcript)|go:"GO:0000018"(regulation of DNA recombination)|go:"GO:0003677"(DNA binding)|dip:DIP-2912N|mint:P13099 - crc64:65EF152F50BF0084 crc64:51DF78936A88B4F4 figure legend:Fig. 4B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2017/03/08 2017/03/08 rogid:6vrkb5T1C2mV3fInk0bzsKuIudQ559292 rogid:7guk14sg6ZTut5+2ip8U/NkS9M0559292 rigid:3RV2wkFtDlY52xcfQyX8JWlsbVc false ha tag:c-c v5 tag:c-c - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q02685 uniprotkb:P13099 intact:EBI-38690|uniprotkb:D6W3Y8|ensemblfungi:YPL024W intact:EBI-19365|uniprotkb:D6VYN4|ensemblfungi:YLR234W psi-mi:rmi1_yeast(display_long)|uniprotkb:RMI1(gene name)|psi-mi:RMI1(display_short)|uniprotkb:NCE4(gene name synonym)|uniprotkb:YPL024W(locus name) psi-mi:top3_yeast(display_long)|uniprotkb:TOP3(gene name)|psi-mi:TOP3(display_short)|uniprotkb:EDR1(gene name synonym)|uniprotkb:YLR234W(locus name)|uniprotkb:L8083.3(orf name)|uniprotkb:DNA topoisomerase III(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mullen et al. (2005) imex:IM-25670|pubmed:15899853 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13946358|imex:IM-25670-12 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_015301.1|sgd:S000005945|mint:Q02685|dip:DIP-4039N|ensemblfungi:YPL024W(gene)|ensemblfungi:YPL024W_mRNA(transcript)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006265"(DNA topological change)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0031422"(RecQ family helicase-topoisomerase III complex)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043596"(nuclear replication fork)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR013894(Region of unknown function DUF1767) refseq:NP_013335.1|sgd:S000004224|go:"GO:0003917"("DNA topoisomerase type I (single strand cut, ATP-independent) activity")|go:"GO:0005634"(nucleus)|go:"GO:0006265"(DNA topological change)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0031422"(RecQ family helicase-topoisomerase III complex)|interpro:IPR000380(DNA topoisomerase, type IA, core)|interpro:IPR003601(DNA topoisomerase, type IA, domain 2)|interpro:IPR003602(DNA topoisomerase, type IA, DNA-binding)|interpro:IPR006171(TOPRIM)|interpro:IPR013497(DNA topoisomerase, type IA, central)|interpro:IPR013824(DNA topoisomerase, type IA, central region, subdomain 1)|interpro:IPR013825(DNA topoisomerase, type IA, central region, subdomain 2)|interpro:IPR013826(DNA topoisomerase, type IA, central region, subdomain 3)|interpro:IPR023405|interpro:IPR023406|interpro:IPR034144|go:"GO:0003916"(DNA topoisomerase activity)|ensemblfungi:YLR234W(gene)|ensemblfungi:YLR234W_mRNA(transcript)|go:"GO:0000018"(regulation of DNA recombination)|go:"GO:0003677"(DNA binding)|dip:DIP-2912N|mint:P13099 - crc64:65EF152F50BF0084 crc64:51DF78936A88B4F4 figure legend:Fig. 5B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") - 2017/03/08 2017/03/08 rogid:6vrkb5T1C2mV3fInk0bzsKuIudQ559292 rogid:7guk14sg6ZTut5+2ip8U/NkS9M0559292 rigid:AOqUNTYjZkSX8ZpDxfUXp0axqNM false ha tag:c-c v5 tag:c-c - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q02685 uniprotkb:P35187 intact:EBI-38690|uniprotkb:D6W3Y8|ensemblfungi:YPL024W intact:EBI-17059|uniprotkb:D6W014|ensemblfungi:YMR190C psi-mi:rmi1_yeast(display_long)|uniprotkb:RMI1(gene name)|psi-mi:RMI1(display_short)|uniprotkb:NCE4(gene name synonym)|uniprotkb:YPL024W(locus name) psi-mi:sgs1_yeast(display_long)|uniprotkb:SGS1(gene name)|psi-mi:SGS1(display_short)|uniprotkb:TPS1(gene name synonym)|uniprotkb:YMR190C(locus name)|uniprotkb:YM9646.02C(orf name)|uniprotkb:Helicase TPS1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mullen et al. (2005) imex:IM-25670|pubmed:15899853 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13946367|imex:IM-25670-14 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_015301.1|sgd:S000005945|mint:Q02685|dip:DIP-4039N|ensemblfungi:YPL024W(gene)|ensemblfungi:YPL024W_mRNA(transcript)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006265"(DNA topological change)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0031422"(RecQ family helicase-topoisomerase III complex)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043596"(nuclear replication fork)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR013894(Region of unknown function DUF1767) go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006265"(DNA topological change)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0007534"(gene conversion at mating-type locus)|go:"GO:0009378"(four-way junction helicase activity)|go:"GO:0010520"(regulation of reciprocal meiotic recombination)|go:"GO:0010947"(negative regulation of meiotic joint molecule formation)|go:"GO:0031422"(RecQ family helicase-topoisomerase III complex)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0031860"(telomeric 3' overhang formation)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0044818"(mitotic G2/M transition checkpoint)|go:"GO:0045132"(meiotic chromosome segregation)|go:"GO:0051276"(chromosome organization)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:0005634"(nucleus)|interpro:IPR002121(Helicase and RNase D C-terminal, HRDC)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|interpro:IPR004589(DNA helicase, ATP-dependent, RecQ type)|interpro:IPR010997(HRDC-like)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR018982|interpro:IPR022758|interpro:IPR027417|interpro:IPR032284|interpro:IPR036388|rcsb pdb:1D8B|interpro:IPR001650(DNA/RNA helicase, C-terminal)|refseq:NP_013915.1|sgd:S000004802|ensemblfungi:YMR190C(gene)|ensemblfungi:YMR190C_mRNA(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0005524"(ATP binding)|dip:DIP-2911N|mint:P35187 - crc64:65EF152F50BF0084 crc64:0DC320B41756A3C3 figure legend:Fig. 5D, 5F|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") - 2017/03/08 2017/05/11 rogid:6vrkb5T1C2mV3fInk0bzsKuIudQ559292 rogid:kSX/9U/Qjnhm6doWBmFCKOC8dJo559292 rigid:sVtn/LnEnQBuAX061seEmfODeW8 false ha tag:c-c v5 tag:c-c - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P13099 uniprotkb:Q02685 intact:EBI-19365|uniprotkb:D6VYN4|ensemblfungi:YLR234W intact:EBI-38690|uniprotkb:D6W3Y8|ensemblfungi:YPL024W psi-mi:top3_yeast(display_long)|uniprotkb:TOP3(gene name)|psi-mi:TOP3(display_short)|uniprotkb:EDR1(gene name synonym)|uniprotkb:YLR234W(locus name)|uniprotkb:L8083.3(orf name)|uniprotkb:DNA topoisomerase III(gene name synonym) psi-mi:rmi1_yeast(display_long)|uniprotkb:RMI1(gene name)|psi-mi:RMI1(display_short)|uniprotkb:NCE4(gene name synonym)|uniprotkb:YPL024W(locus name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mullen et al. (2005) imex:IM-25670|pubmed:15899853 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-14061058|imex:IM-25670-16 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_013335.1|sgd:S000004224|go:"GO:0003917"("DNA topoisomerase type I (single strand cut, ATP-independent) activity")|go:"GO:0005634"(nucleus)|go:"GO:0006265"(DNA topological change)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0031422"(RecQ family helicase-topoisomerase III complex)|interpro:IPR000380(DNA topoisomerase, type IA, core)|interpro:IPR003601(DNA topoisomerase, type IA, domain 2)|interpro:IPR003602(DNA topoisomerase, type IA, DNA-binding)|interpro:IPR006171(TOPRIM)|interpro:IPR013497(DNA topoisomerase, type IA, central)|interpro:IPR013824(DNA topoisomerase, type IA, central region, subdomain 1)|interpro:IPR013825(DNA topoisomerase, type IA, central region, subdomain 2)|interpro:IPR013826(DNA topoisomerase, type IA, central region, subdomain 3)|interpro:IPR023405|interpro:IPR023406|interpro:IPR034144|go:"GO:0003916"(DNA topoisomerase activity)|ensemblfungi:YLR234W(gene)|ensemblfungi:YLR234W_mRNA(transcript)|go:"GO:0000018"(regulation of DNA recombination)|go:"GO:0003677"(DNA binding)|dip:DIP-2912N|mint:P13099 refseq:NP_015301.1|sgd:S000005945|mint:Q02685|dip:DIP-4039N|ensemblfungi:YPL024W(gene)|ensemblfungi:YPL024W_mRNA(transcript)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006265"(DNA topological change)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0031422"(RecQ family helicase-topoisomerase III complex)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043596"(nuclear replication fork)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR013894(Region of unknown function DUF1767) - crc64:51DF78936A88B4F4 crc64:65EF152F50BF0084 figure legend:Fig. 5A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") - 2017/03/08 2017/05/11 rogid:7guk14sg6ZTut5+2ip8U/NkS9M0559292 rogid:6vrkb5T1C2mV3fInk0bzsKuIudQ559292 rigid:AOqUNTYjZkSX8ZpDxfUXp0axqNM false v5 tag:c-c ha tag:c-c - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q02685 uniprotkb:P35187 intact:EBI-38690|uniprotkb:D6W3Y8|ensemblfungi:YPL024W intact:EBI-17059|uniprotkb:D6W014|ensemblfungi:YMR190C psi-mi:rmi1_yeast(display_long)|uniprotkb:RMI1(gene name)|psi-mi:RMI1(display_short)|uniprotkb:NCE4(gene name synonym)|uniprotkb:YPL024W(locus name) psi-mi:sgs1_yeast(display_long)|uniprotkb:SGS1(gene name)|psi-mi:SGS1(display_short)|uniprotkb:TPS1(gene name synonym)|uniprotkb:YMR190C(locus name)|uniprotkb:YM9646.02C(orf name)|uniprotkb:Helicase TPS1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Mullen et al. (2005) imex:IM-25670|pubmed:15899853 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-14061068|imex:IM-25670-18 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_015301.1|sgd:S000005945|mint:Q02685|dip:DIP-4039N|ensemblfungi:YPL024W(gene)|ensemblfungi:YPL024W_mRNA(transcript)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006265"(DNA topological change)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0031422"(RecQ family helicase-topoisomerase III complex)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043596"(nuclear replication fork)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR013894(Region of unknown function DUF1767) go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006265"(DNA topological change)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0007534"(gene conversion at mating-type locus)|go:"GO:0009378"(four-way junction helicase activity)|go:"GO:0010520"(regulation of reciprocal meiotic recombination)|go:"GO:0010947"(negative regulation of meiotic joint molecule formation)|go:"GO:0031422"(RecQ family helicase-topoisomerase III complex)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0031860"(telomeric 3' overhang formation)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0044818"(mitotic G2/M transition checkpoint)|go:"GO:0045132"(meiotic chromosome segregation)|go:"GO:0051276"(chromosome organization)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:0005634"(nucleus)|interpro:IPR002121(Helicase and RNase D C-terminal, HRDC)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|interpro:IPR004589(DNA helicase, ATP-dependent, RecQ type)|interpro:IPR010997(HRDC-like)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR018982|interpro:IPR022758|interpro:IPR027417|interpro:IPR032284|interpro:IPR036388|rcsb pdb:1D8B|interpro:IPR001650(DNA/RNA helicase, C-terminal)|refseq:NP_013915.1|sgd:S000004802|ensemblfungi:YMR190C(gene)|ensemblfungi:YMR190C_mRNA(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0005524"(ATP binding)|dip:DIP-2911N|mint:P35187 - crc64:65EF152F50BF0084 crc64:0DC320B41756A3C3 figure legend:Fig. 5 C/E|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") - 2017/03/08 2017/05/11 rogid:6vrkb5T1C2mV3fInk0bzsKuIudQ559292 rogid:kSX/9U/Qjnhm6doWBmFCKOC8dJo559292 rigid:sVtn/LnEnQBuAX061seEmfODeW8 false ha tag:c-c v5 tag:c-c - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot)