#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q02763	uniprotkb:O15123-1	intact:EBI-2257090|uniprotkb:A8K6W0|uniprotkb:Q5TCU2|uniprotkb:B4DH20|uniprotkb:B4DHD3|uniprotkb:E7EWI2|uniprotkb:Q8IV34|uniprotkb:D3DRK5|ensembl:ENSP00000369375	intact:EBI-15552475|ensembl:ENSP00000314897	psi-mi:tie2_human(display_long)|uniprotkb:TEK(gene name)|psi-mi:TEK(display_short)|uniprotkb:TIE2(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor TIE-2(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor TEK(gene name synonym)|uniprotkb:Tunica interna endothelial cell kinase(gene name synonym)|uniprotkb:p140 TEK(gene name synonym)|uniprotkb:Endothelial tyrosine kinase(gene name synonym)|uniprotkb:Tyrosine kinase with Ig and EGF homology domains-2(gene name synonym)|uniprotkb:VMCM(gene name synonym)|uniprotkb:VMCM1(gene name synonym)	psi-mi:o15123-1(display_long)|uniprotkb:ANGPT2(gene name)|psi-mi:ANGPT2(display_short)	psi-mi:"MI:0071"(molecular sieving)	Barton et al. (2005)	pubmed:15893672|doi:10.1016/j.str.2005.03.009|imex:IM-14199	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15552481|imex:IM-14199-1|dip:DIP-10944E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000450.2|dip:DIP-6047N|refseq:NP_001277006.1|refseq:NP_001277007.1|ensembl:ENSG00000120156(gene)|ensembl:ENST00000380036(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001958"(endochondral ossification)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007507"(heart development)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019838"(growth factor binding)|go:"GO:0032878"(regulation of establishment or maintenance of cell polarity)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034451"(centriolar satellite)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043627"(response to estrogen)|go:"GO:0045121"(membrane raft)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048014"(Tie signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051591"(response to cAMP)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060216"(definitive hemopoiesis)|go:"GO:0060347"(heart trabecula formation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0072012"(glomerulus vasculature development)|go:"GO:1902533"(positive regulation of intracellular signal transduction)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR018941|interpro:IPR020635|interpro:IPR036116|interpro:IPR036179|mint:Q02763|rcsb pdb:1FVR|rcsb pdb:2GY5|rcsb pdb:2GY7|rcsb pdb:2OO8|rcsb pdb:2OSC|rcsb pdb:2P4I|rcsb pdb:2WQB|rcsb pdb:3BEA|rcsb pdb:3L8P|rcsb pdb:4K0V|rcsb pdb:4X3J|rcsb pdb:5MYA|rcsb pdb:5MYB|rcsb pdb:5UTK|rcsb pdb:6MWE|reactome:R-HSA-210993|reactome:R-HSA-5673001	ensembl:ENSG00000091879(gene)|ensembl:ENST00000325203(transcript)|intact:EBI-2912111(isoform-parent)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/04	2017/08/10	rogid:iZHZ6RvLXT65o6FTQaHW+cnrX1o9606	rogid:p1gSsi5cIt3Lp6o5fA4fVAtvZD49606	rigid:mPg1eFmFuJbz1da5Lb+Up2Dm83U	false	binding-associated region:1-448	binding-associated region:276-496|mutation disrupting interaction:476-476,475-475,469-469|mutation disrupting interaction:473-473,468-468	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:Q02763	uniprotkb:O15123-1	intact:EBI-2257090|uniprotkb:A8K6W0|uniprotkb:Q5TCU2|uniprotkb:B4DH20|uniprotkb:B4DHD3|uniprotkb:E7EWI2|uniprotkb:Q8IV34|uniprotkb:D3DRK5|ensembl:ENSP00000369375	intact:EBI-15552475|ensembl:ENSP00000314897	psi-mi:tie2_human(display_long)|uniprotkb:TEK(gene name)|psi-mi:TEK(display_short)|uniprotkb:TIE2(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor TIE-2(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor TEK(gene name synonym)|uniprotkb:Tunica interna endothelial cell kinase(gene name synonym)|uniprotkb:p140 TEK(gene name synonym)|uniprotkb:Endothelial tyrosine kinase(gene name synonym)|uniprotkb:Tyrosine kinase with Ig and EGF homology domains-2(gene name synonym)|uniprotkb:VMCM(gene name synonym)|uniprotkb:VMCM1(gene name synonym)	psi-mi:o15123-1(display_long)|uniprotkb:ANGPT2(gene name)|psi-mi:ANGPT2(display_short)	psi-mi:"MI:0038"(dynamic light scattering)	Barton et al. (2005)	pubmed:15893672|doi:10.1016/j.str.2005.03.009|imex:IM-14199	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15552511|imex:IM-14199-2|dip:DIP-10944E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000450.2|dip:DIP-6047N|refseq:NP_001277006.1|refseq:NP_001277007.1|ensembl:ENSG00000120156(gene)|ensembl:ENST00000380036(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001958"(endochondral ossification)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007507"(heart development)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019838"(growth factor binding)|go:"GO:0032878"(regulation of establishment or maintenance of cell polarity)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034451"(centriolar satellite)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043627"(response to estrogen)|go:"GO:0045121"(membrane raft)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048014"(Tie signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051591"(response to cAMP)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060216"(definitive hemopoiesis)|go:"GO:0060347"(heart trabecula formation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0072012"(glomerulus vasculature development)|go:"GO:1902533"(positive regulation of intracellular signal transduction)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR018941|interpro:IPR020635|interpro:IPR036116|interpro:IPR036179|mint:Q02763|rcsb pdb:1FVR|rcsb pdb:2GY5|rcsb pdb:2GY7|rcsb pdb:2OO8|rcsb pdb:2OSC|rcsb pdb:2P4I|rcsb pdb:2WQB|rcsb pdb:3BEA|rcsb pdb:3L8P|rcsb pdb:4K0V|rcsb pdb:4X3J|rcsb pdb:5MYA|rcsb pdb:5MYB|rcsb pdb:5UTK|rcsb pdb:6MWE|reactome:R-HSA-210993|reactome:R-HSA-5673001	ensembl:ENSG00000091879(gene)|ensembl:ENST00000325203(transcript)|intact:EBI-2912111(isoform-parent)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/04	2017/08/10	rogid:iZHZ6RvLXT65o6FTQaHW+cnrX1o9606	rogid:p1gSsi5cIt3Lp6o5fA4fVAtvZD49606	rigid:mPg1eFmFuJbz1da5Lb+Up2Dm83U	false	binding-associated region:1-448	binding-associated region:276-496	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q02763	uniprotkb:O15123-1	intact:EBI-2257090|uniprotkb:A8K6W0|uniprotkb:Q5TCU2|uniprotkb:B4DH20|uniprotkb:B4DHD3|uniprotkb:E7EWI2|uniprotkb:Q8IV34|uniprotkb:D3DRK5|ensembl:ENSP00000369375	intact:EBI-15552475|ensembl:ENSP00000314897	psi-mi:tie2_human(display_long)|uniprotkb:TEK(gene name)|psi-mi:TEK(display_short)|uniprotkb:TIE2(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor TIE-2(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor TEK(gene name synonym)|uniprotkb:Tunica interna endothelial cell kinase(gene name synonym)|uniprotkb:p140 TEK(gene name synonym)|uniprotkb:Endothelial tyrosine kinase(gene name synonym)|uniprotkb:Tyrosine kinase with Ig and EGF homology domains-2(gene name synonym)|uniprotkb:VMCM(gene name synonym)|uniprotkb:VMCM1(gene name synonym)	psi-mi:o15123-1(display_long)|uniprotkb:ANGPT2(gene name)|psi-mi:ANGPT2(display_short)	psi-mi:"MI:0028"(cosedimentation in solution)	Barton et al. (2005)	pubmed:15893672|doi:10.1016/j.str.2005.03.009|imex:IM-14199	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15552532|imex:IM-14199-3|dip:DIP-10944E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000450.2|dip:DIP-6047N|refseq:NP_001277006.1|refseq:NP_001277007.1|ensembl:ENSG00000120156(gene)|ensembl:ENST00000380036(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001958"(endochondral ossification)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007507"(heart development)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019838"(growth factor binding)|go:"GO:0032878"(regulation of establishment or maintenance of cell polarity)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034451"(centriolar satellite)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043627"(response to estrogen)|go:"GO:0045121"(membrane raft)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048014"(Tie signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051591"(response to cAMP)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060216"(definitive hemopoiesis)|go:"GO:0060347"(heart trabecula formation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0072012"(glomerulus vasculature development)|go:"GO:1902533"(positive regulation of intracellular signal transduction)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR018941|interpro:IPR020635|interpro:IPR036116|interpro:IPR036179|mint:Q02763|rcsb pdb:1FVR|rcsb pdb:2GY5|rcsb pdb:2GY7|rcsb pdb:2OO8|rcsb pdb:2OSC|rcsb pdb:2P4I|rcsb pdb:2WQB|rcsb pdb:3BEA|rcsb pdb:3L8P|rcsb pdb:4K0V|rcsb pdb:4X3J|rcsb pdb:5MYA|rcsb pdb:5MYB|rcsb pdb:5UTK|rcsb pdb:6MWE|reactome:R-HSA-210993|reactome:R-HSA-5673001	ensembl:ENSG00000091879(gene)|ensembl:ENST00000325203(transcript)|intact:EBI-2912111(isoform-parent)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/04	2017/08/10	rogid:iZHZ6RvLXT65o6FTQaHW+cnrX1o9606	rogid:p1gSsi5cIt3Lp6o5fA4fVAtvZD49606	rigid:mPg1eFmFuJbz1da5Lb+Up2Dm83U	false	binding-associated region:1-448	binding-associated region:276-496	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)